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rcn;id;acronym;status;programme;topics;frameworkProgramme;title;startDate;endDate;projectUrl;objective;totalCost;ecMaxContribution;call;fundingScheme;coordinator;coordinatorCountry;participants;participantCountries;subjects 196706;673348;LCODA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Electronic scanning MIMO Radar for railway level crossing obstruction detection alerting;1/06/2015;30/11/2015;;"The overall project objective is to develop an innovative low cost, low maintenance, high performance, high reliability electronic scanning radar sensor system (ES24) for level crossing obstacle detection, capable of detecting objects ranging from large vehicles to bicycles & people, including people lying down. Key features are, only a single sensor is needed to identify the wide range of object sizes, the sensor has no rotating parts & operates in all weathers.ES24 will enable track operators to monitor whether the track is clear or an object has been detected, significantly improving safety for both train passengers & crossing users.
More than 2,000 significant accidents occur each year on EU member states railways. Accounted economic costs are as high as 1.7bn. In 2013, 25% of all significant railway accidents (8% involving pedestrians, 17% vehicles) occurred at level crossings (LCs). LC safety a key focus area across EU & global rail networks. The European Rail Agency report 573 significant LC accidents occurred in the EU in 2012, resulting in 373 deaths & 336 serious injuries. Each significant LC accident is estimated to cost 1.7m, i.e. 974m for 2012. LC accidents have damaging impact on the key rail transport strengths: safety, reliability & speed.
Current object detection (LCOD) systems are expensive, have limited capability in terms of the size of object detected, need combined laser & radar sensor solutions to meet operator needs & generally have rotating parts requiring on-going maintenance. There are currently about 120 000 LCs in the EU. Reducing system cost & improving the performance dramatically increases the addressable LCOD market.
The Phase 1 project will deliver a detailed report providing a costed technical programme and detailed exploitation plan for the development of a low cost high performance Level Crossing obstacle detection system in phase 2 for high volume implementation in the rail market across Europe and globally.";71429;50000;H2020-SMEINST-1-2014;SME-1;GUIDANCE NAVIGATION HOLDINGS LTD;UK;;; 196709;660362;PASS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Paleozoic Seafloor Spreading;4/09/2015;3/09/2017;;"It is now recognised that large oceanic detachment faults are fundamentally important along slow-spreading rate portions of the mid-ocean ridge system. These fault systems have been the target of numerous scientific expeditions leading to a new paradigm of detachment-mode spreading. However, in the modern oceans this style of spreading can only be documented back to 10-12 Ma. To understand these systems in the deep geological past it is necessary to work on ancient examples of detachment faults in ophiolites, slices of oceanic lithosphere that have been emplaced tectonically onto continental margins and which expose ocean floor structures in 3-D. Recent work in the Mirdita ophiolite of Albania has demonstrated that detachment-mode spreading operated in the Jurassic period. This project will extend this record back to the Palaeozoic, by investigating a detachment system preserved in the Thetford Mines Ophiolite of Canada. An integrated field-based structural and palaeomagnetic investigation will test the hypothesis that this example provides the oldest known analogue for modern oceanic detachment systems. Objectives are to: (i) systematically back-strip successive tectonic events that have affected the ophiolite, in order to recover primary seafloor relationships; (ii) determine whether relative tectonic rotation has occurred across the detachment fault, a defining feature of modern examples; and (iii) quantify the role of large- and small-scale faulting in accommodating displacement within the detachment system. The project will provide: (i) extensive training in field-based tectonic applications of palaeomagnetism, directly complementing the Fellows existing expertise and experience in laboratory techniques, thereby allowing her to conduct future investigations in complex tectonic environments; and (ii) engagement with the international oceanic scientific community, opening future opportunities to move into oceanic geodynamic research.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF PLYMOUTH;UK;;; 196694;672521;HyPoGA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Feasibility study of a superefficient hybrid power train as a replacement unit for existing engines - Hybrid Power for General Aviation (HyPoGA);1/05/2015;31/10/2015;;"Worldwide, over 280.000 General Aviation (GA) aircrafts are in use (28.000 in Europe) and most aircraft in this engine-power class (approx. 200 kW) are operated several hours per day in commercial services. The total operating costs are about 213 T per year. Combustion engines are designed for the maximum power needed for take-off and climbs (peak-loading), though in cruise flight only approx. 65 % of the power is required. The overall objective of the HyPoGA innovation project is to develop a superefficient, hybridized 200 kW aircraft engine by integration of a 140 kW combustion and a 60 kW electrical engine which will allow a fuel reduction of about 30% and a total cost reduction of 27% ~ 48 T. This engine will be certified as a replacement unit according to EU and US aviation laws and regulations. The annual demand for replacement engines is ~3.000. The additional weight of the electrical components (electrical engine, batteries) is counter played by the weight reduction of a smaller combustion engine and the fuel savings. The innovative power train will contribute significantly to reduced costs of operations and a massive reduction of CO2 emission. Furthermore, the electrical engine constitutes a back-up increasing the safety of aircraft operations (two engines instead of one). These aspects create a unique selling point and competitive advantage for potential customers.

The objectives of the feasibility study are (i) a market research study and analysis (SWOT-Analysis), (ii) a technological feasibility (e.g. final design definition) and (iii) an economic and financial feasibility (including marketing strategy, certification, financial plan). The results will be elaborated in a business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;JOCKEL BERNHARD;DE;LIMBACH STEFAN;DE; 196693;672228;PARK-IT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Unobtrusive, continuous and quantitative assessment of Parkinsons disease: hard evidence foroptimal disease management with information technologies;1/06/2015;30/11/2015;;"Sense4Care S.L. (S4C) is high-tech SME constituted in Barcelona in 2013 as a spin-off of the Universitat Politcnica de Catalunya - BarcelonaTech (UPC) with a clear objective: taking to the market the results of several research projects. UPC itself holds 5% of the shares of the company, and the rest belongs to professors, researchers and investors. UPC was the Coordinator and main beneficiary of the FP7-ICT project called REMPARK1 project, and has legally transferred the exploitation rights of the project results to S4C, with the aim of commercialising a product that can dramatically improve the lives of Parkinsons Disease (PD) sufferers.

The main result from the FP7-REMPARK project is the kinetic monitor PARK-IT, which can be exploited as a standalone product. PARK-IT is a new gold-standard, continuous and quantitative monitoring medical device for assessing the status of Parkinson Disease patients. PARK-IT device, based in movement detection and complex algorithms, allows the doctors to precisely adjust the medication of PD patients, overcoming one of the main problems that PD patients face. It constitutes a disruptive innovation answering to an unmet need.

The present innovation business project is therefore focused in taking this device to the market through a clear and innovative business model.";71429;50000;H2020-SMEINST-1-2014;SME-1;SENSE4CARE SL;ES;;; 196679;640627;DOS;SIGNED;H2020-EU.1.1.;ERC-StG-2014;H2020;Domestic Servants in Colonial South Asia;1/10/2015;30/09/2018;;"Title: Domestic Servants in Colonial South Asia
The ubiquity of domestic servants in contemporary South Asia has received scarce attention from historians. Servant pasts have been used instrumentally to write others histories. In contrast, this project centrally situates servants at the intersection of households, labour and forms of relationships. Everyday relationships between servants and masters were based upon labour and wage on the one hand and intimacy and affect on the other.
The paradox of pervasive visibility of servants and their marginality in history writing is explicable once theoretical templates are laid bare. To achieve that, the project raises three key questions: 1) How did servant labour unsettle the often rigid and easy categorisation of work into productive, reproductive and unproductive? 2) How did the multiplicity of relational axes forged around male-male, male-female and female-female affects and hierarchies question the standard accounts framed by assumptions of heterosexual interactions? 3) How did the hierarchies of social and shared worlds marked by race, class, caste, religion, rank, profession and age shape the legal, juridical and criminal bases of labour regulation?
Servant histories need to move beyond the employers household into the realm of ghettoes, streets, bazaars, barracks, hospitals and mission houses. Two research units involving the PI and a co-applicant cover two periods of colonial history: one, the period from the early eighteenth to the mid-nineteenth; and second, from the mid-nineteenth to the twentieth century.
By locating servants in the wider social, political, and moral world, the project combines empirically grounded case studies with the political economy of imperialism. It aims to develop a new understanding of labour, gender and social history, each of these in turn being rewritten, even as they lay the foundations of the first historically grounded account of domestic work in South Asia.";899849;899849;ERC-2014-STG;ERC-STG;GEISTESWISSENSCHAFTLICHE ZENTREN BERLIN E.V.;DE;"HUMBOLDT-UNIVERSITAT ZU BERLIN;University of York";"DE;UK"; 196708;654933;3Dconvert;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The dynamics of the mammalian epigenome during transcription factor-induced cell fate conversion;1/05/2015;30/04/2017;;Cell fate conversion processes bear considerable therapeutic potential yet are poorly understood, and have thus remained slow, inefficient and difficult to translate into medical applications. The low conversion frequency in current systems, such as classic reprogramming to induced pluripotent stem (iPS) cells, has precluded a molecular study of the critical early conversion events. We propose an interdisciplinary, exhaustive and unbiased approach to unravel the molecular events that accompany cell fate conversion processes, in particular during the early phase, using two uniquely efficient and controllable experimental systems. Special emphasis will be put on documenting the dynamics of three-dimensional genome topology, as this potential epigenetic conversion barrier has not yet been systemically characterized during cell fate conversions. We will apply genome-wide chromosome conformation capture and other genomic technologies on B cells undergoing nearly 100% efficient transdifferentiation into macrophages or reprogramming into iPS cells. In-depth computational analyses and dataset integration will reveal the dynamic relationships between transcription factor binding, key epigenetic regulatory mechanisms including genome topology, and the gene expression changes that ultimately lead to the implementation of a new cellular phenotype. Acquiring such insights will signify a breakthrough in our understanding of the epigenetic features that underpin cell identity and plasticity. Besides significantly advancing the state-of-the-art, the proposed action will maximize the applicants capacity of reaching professional maturity and scientific independence.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO CENTRE DE REGULACIO GENOMICA;ES;;; 196678;639633;MASSIVE;SIGNED;H2020-EU.1.1.;ERC-StG-2014;H2020;Multinationals, Institutions and Innovation in Europe;1/06/2015;31/05/2020;;"Multinational Enterprises (MNEs) are key tectonic forces, shaping the mountains in a far-from-flat world economic geography. In 2010, MNEs generated value added for approximately US$16 trillion accounting for more than a quarter of world GDP (UNCTAD, 2012). The progessive expansion of firms from emerging economies into multinational enterprises is unprecedented. Outflows of FDIs from developing economies reached the record level of $426 billion in 2012, corresponding to 31% of global outflows, up from 16% in 2007 (UNCTAD, 2013).
However, there is no consensus in the academic literature on both the factors able to shape the long-term location decisions of MNEs and, more generally, on the ultimate impact of MNEs on their host economies. This lack of consensus reflects three fundamental gaps in the existing literature. First the omission of some fundamental determinants of MNEs investment decisions in traditional national-level analyses. Territorial/spatial factors, MNEs heterogeneity and local institutional conditions have been often overlooked in MNEs location analyses. Second the limited attention to the broader set of impacts of MNEs in their host economies and the role of institutional factors as selective filters for these impacts. Third the intimate inter-connection between location motives and impacts has remained unexplored in the grey areas between separate streams of literature.
This research project will investigate the location strategies of MNEs and their territorial impacts addressing these three fundamental gaps in the existing literature, shedding new light on the factors shaping the economic geography of MNEs and their impacts and providing policy-makers at all levels with new tools to promote innovation, employment and economic recovery after the current economic crisis.";1276880;1276880;ERC-2014-STG;ERC-STG;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;UK;;; 196692;672199;ImplantFreeSpine;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Worlds first complete motion-preservation 'Implant-less' surgical correction for Scoliosis;1/06/2015;31/10/2015;;"Scoliosis affects 2-3% of the world population i.e. about 12 million people in the EU. 20,000 cases of severe scoliosis are reported each year in the EU but less than 3,000 cases ever undergo surgery due to cost and complexity of the surgery. Severe cases of scoliosis are treated by spinal fusion; a major surgical procedure that makes the spine permanently rigid restricting physical activities and permanent arrest of spinal growth. The impact of spinal deformity caused by scoliosis on the quality of life before and after surgery is huge compared with other chronic conditions such as arthritis, chronic obstructive lung disease, diabetes and hypertension.
Due to the need for an alternative method for better correction of scoliosis deformities we have developed novel devices and a highly innovative care model involving a safer and significantly less invasive, complete cure which preserves spinal mobility and growth potential. Our solution will result in reduced cost of treatment by over 40% because of shorter hospitalisation, reduced operating time, elimination of additional procedures and lifetime care costs.
Spine surgery currently holds a 10.2 billion global market share and is estimated to grow at a compound annual growth rate of 6.9% to reach 17.5 billion by 2022. We aim to capture a market share of 0.1% in 5 years post commercialisation of our project and earn compound revenues of 42.5 million by selling our devices over the same period.
In Phase 1 of this project we intend to conduct detailed planning of the testing and design optimisation phases, carry out a market study plan, identify and engage international partners and develop a draft business plan for use upon commercialisation within a period of 6 months.
In Phase 2 we will develop an advanced prototype meeting relevant EU and US Medical Devices Directives, demonstrate surgical techniques, rehabilitation strategies, and post-operative procedures and also conduct introductory marketing of our devices.";71429;50000;H2020-SMEINST-1-2014;SME-1;ATC GROUP LIMITED;UK;;; 196659;674710;CLOUD-VAS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Cloud based Vessel Allocation Decision Support System for Vessel Chartering;1/06/2015;31/05/2017;;CLOUD-VAS is a CLOUD-based Vessel Allocation decision Support tool derived from the by oil chartering companies expressed need for an elementary, user friendly software solution that is accessible any place, any time. CLOUD-VAS helps Large Oil & Gas companies and Large Ship-owners make sharp decisions on which vessels to charter, saving enormously on chartering costs and fuel consumption equalizing lower CO2 emission. The Vessel Allocation Problem is a widely known managerial problem for transportation companies relying on maritime shipping for transportation of their bulk. Current methods for Vessel Allocation are based on linear, nonlinear, integer, stochastic and global programming solvers proven to perform well but complicated are in use and not protected by user access rights packages which entails alteration of data by virtually anyone is possible often leading to significant time and monetary losses. The outcome CLOUD-VAS will provide a flexible and affordable optimisation platform that enables to significantly minimise operational costs and fuel consumption (thus GHG emissions). Minimising carbon footprint and fuel consumption is a strategic direction for Waterborne Transportation overall in Europe. Reduced environmental impact and enhanced fuel efficiency will contribute to economic prosperity and environmental sustainability as two pillars of sustainability. This makes the project strongly related to the current EU wide challenges for the Maritime Transportation Industry to cut back its CO2 emissions and contribute to their strive for delivering products in a timely and cost effective manner. Besides CLOUD-VASs benefits like an integrated report system and the implemented user access rights packages the real innovation lies in it being a ready-to-use cloud-based solution. CLOUD-VAS is the first and so far the only Cloud Based Vessel Allocation Decision Support Tool in the world and will be an important innovation for the Maritime Transportation Industry.;1803125;1262187,5;H2020-SMEINST-2-2014;SME-2;PROMATEK DENIZCILIK TEKNOLOJILERI VE MUHENDISLIK COZUMLERI SANAYI VE TTICARET LIMITED SIRKETI;TR;;; 196691;671980;RAd;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;RAd (Responsible Advertising) - An innovative donate-per-view digital video advertising model;1/06/2015;31/10/2015;;"The so called legacy media players such as broadcast TV and newspapers (hereinafter referred to simply as media) face incredible challenges while transitioning into the new media and the digital space. Traditionally, advertisement has always played a key role in balancing out the financial scale for media but with the transition to digital and the dispersal of advertising revenue to non-editorial and social media giants such as Google, Facebook and Youtube, risk of long-term advertisement revenue losses increases dramatically.
Digital video advertisement (DVA) is experiencing exponential growth with a 1Billion market value predicted for the UK alone in 2017. RAd (responsible advertisement) is an innovative DVA product that combines advertisement with Corporate Social Responsibility. Rad connects media publishers and advertisers, with non-profit organizations and end-users in a win-win donate-per-view interaction model where end-users support non-profits through their ad viewership.
The media sector is critical for pluralism and democracy and employs more than 10 million people in the EU. As we explore in this proposal, in the UK alone RAd has the potential to help bring new income to the media (100m) while bringing additional financial support to non-profit organizations (20m). Ultimately, we believe RAd has the potential to impact the way we think advertisement altogether, reinforcing the EUs role as an innovative region and though leader on cross-nation and cross-industry innovative thinking.
The goal of this project is to assess the feasibility of RAD by combining market analysis and strategy development, with a field pilot ran together with Norwegian broadcaster TV2 and newspaper BA to test and refine the proposed business model. The project will run for 6 months and result in a feasibility report that includes all the results and raw data collected throughout the project, the conclusions extrapolated from this data, and the final RAD business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;MOBILETECH AS;NO;;; 196704;654367;EarthServer-2;SIGNED;H2020-EU.1.4.1.3.;EINFRA-1-2014;H2020;Agile Analytics on Big Data Cubes;1/05/2015;30/04/2018;;"EarthServer-2 makes Agile Analytics on Big Earth Data Cubes of sensor, image, simulation, and statistics data a commodity for non-experts and experts alike through
navigation, extraction, aggregation, and recombining of any-size space/time data cubes;
easy to install & maintain value-adding services extending the existing portfolio of data and compute centers;
based on open standards, in particular: the OGC Big Data standards and the forthcoming ISO SQL/MDA (Multi-Dimensional Arrays) standard.

In the Joint Research Activity, the project will advance the existing, world-leading rasdaman Array Database technology wrt. query functionality, inter-federation data processing with automatic data and query distribution, tape archive integration, and 3D/4D visualization based on NASAs virtual globe technology.

In the Services Activity, large data centers (ECMWF, PML, MEEO/ESA, GeoScience Australia, JacobsUni) will set up water, air, weather, and planetary services on 3D & 4D data cubes up to Petabyte-size with user-tailored clients for both visual and textual ad-hoc mix&match.

In the Networking Activity, the project will advance open Big Data standards in OGC, RDA, and ISO (in particular: write ISO SQL/MDA). Further, all adequate channels will be used for strong dissemination & exploitation, specifically: writing a monograph explaining OGC Big Geo Data standards; scientific publications & active conference organization; Earth science data user workshops for each domain addressed; actively contributing technology & experience to GEO / GEOSS and further bodies; establish standardized Big Geo Data benchmark and run it against EarthServer-2 and further relevant systems.

Altogether, EarthServer-2 will maintain and extend the lead in Big Earth Data services established in the highly successful EarthServer-1 project. Being already supported by ESA, rasdaman will form an enabling building block for COPERNICUS / Sentinel.";2839743,75;2839743;H2020-EINFRA-2014-2;RIA;JACOBS UNIVERSITY BREMEN GGMBH;DE;"PLYMOUTH MARINE LABORATORY;COMMUNICATION & INFORMATION TECHNOLOGIES EXPERTS ANONYMOS ETAIREIA SYMVOULEFTIKON KAI ANAPTYXIAKON YPIRESION;EUROPEAN CENTRE FOR MEDIUM-RANGE WEATHER FORECASTS;RASDAMAN GMBH;METEOROLOGICAL AND ENVIRONMENTAL EARTH OBSERVATION SRL;THE AUSTRALIAN NATIONAL UNIVERSITY";"UK;EL;DE;IT;AU"; 196677;637510;FAnFArE;SIGNED;H2020-EU.1.1.;ERC-StG-2014;H2020;Fourier Analysis For/And Partial Differential Equations;1/06/2015;31/05/2020;;"'This project aims to develop the field of Harmonic Analysis, and more precisely to study problems at the interface between Fourier Analysis and PDEs (and also some Geometry).
We are interested in two aspects of the Fourier Analysis:

(1) The Euclidean Fourier Analysis, where a deep analysis can be performed using specificities as the notion of 'frequencies' (involving the Fourier transform) or the geometry of the Euclidean balls. By taking advantage of them, this proposal aims to pursue the study and bring novelties in three fashionable topics: the study of bilinear/multilinear Fourier multipliers, the development of the 'space-time resonances' method in a systematic way and for some specific PDEs, and the study of nonlinear transport equations in BMO-type spaces (as Euler and Navier-Stokes equations).

(2) A Functional Fourier Analysis, which can be performed in a more general situation using the notion of 'oscillation' adapted to a heat semigroup (or semigroup of operators). This second Challenge is (at the same time) independent of the first one and also very close. It is very close, due to the same point of view of Fourier Analysis involving a space decomposition and simultaneously some frequency decomposition. However they are quite independent because the main goal is to extend/develop an analysis in the more general framework given by a semigroup of operators (so without using the previous Euclidean specificities). By this way, we aim to transfer some results known in the Euclidean situation to some Riemannian manifolds, Fractals sets, bounded open set setting, ... Still having in mind some applications to the study of PDEs, such questions make also a connexion with the geometry of the ambient spaces (by its Riesz transform, Poincar inequality, ...). I propose here to attack different problems as dispersive estimates, 'L^p'-version of De Giorgi inequalities and the study of paraproducts, all of them with a heat semigroup point of view.'";940540,34;940540,34;ERC-2014-STG;ERC-STG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196658;671846;PCSP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Odour-GPCRs based technology for detection and stratification of cancer: Prostate Cancer Smell Print as first vertical market;1/05/2015;31/10/2015;;PCSP project is born out of the unique expertise developed after years of R&D at Canvax Biotech, and aims at transferring a technology to cover an unmet clinical need, accurate diagnosis of prostate cancer (PCa). Canvax owns a unique set of patented technologies: i) high expression of olfactory receptors (oGPCRs) in heterologous cells, ii) coupling to a signalling cascade and iii) readable fluorescent assays to quantify oGPCR activation. Canvax is producing an array of cells expressing oGPCRs that could be used to detect several types of cancer, including PCa, by detecting cancer-associated volatile organic compounds in urine. The technology is currently being tested in a PCa clinical trial. PCa detection has been widely carried out using the prostate specific antigen test. However, its low accuracy resulted in a high percentage of false positives and a still appreciable amount of false negatives. Several recent studies showed that trained dogs could detect PCa from urine samples with the higher accuracy. However, the use of dogs in clinic is difficult and non-scalable. Canvax PCSP test resembles a dog nose that pretends to be a universal screening method for PCa-type discrimination identifying, in simple urine test, patients in need of further, more invasive diagnostic procedures with higher accuracy than current standard of care, saving stress, anxiety and unnecessary risky procedures. The easy use and low cost of this technology makes it ideal for broad adoption. Different scenarios have been described for market penetration and would be subject of the feasibility study during phase I: Smell print definition, regulatory and market permits acquisition, clinical trial design, identification of best-selling points, EU extension and financial costs will be analysed. The appropriate measures will be applied during phase II, together with prototype validation in a large clinical trial to gain recognition within the physicians, and initial exploitation of the technology;71429;50000;H2020-SMEINST-1-2014;SME-1;CANVAX BIOTECH SL;ES;;; 196646;662561;Testforall;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;FOOD SAFETY CONTROLS FOR ALL;1/04/2015;30/09/2015;;"Food Safety controls for all
ZEULAB (www.zeulab.com) is a biotechnology company specialized in the development, production and commercialization of food diagnostics tests. Our dynamic and proactive team of 25 people invests annually 25% of its activity in R&D projects. As a result of this work during almost 20 years we have developed a wide range of innovative solutions in the main areas of Food Safety and Quality (residues, pathogens, adulterations, toxins ...). ZEULABs test kits are commercialized worldwide through a network of distributors specialized in food diagnostics. Our company has an annual turnover around 3 million Euros and exports 70% of its products in more than 40 countries.
The World Health Organization considers antibiotic resistance as one of the three greatest threats to human health for the next decades. Control of antibiotics in the primary sector and food chain is therefore one of main objectives of EU authorities. Unfortunately, there is a lack of suitable analytical systems for the primary sector (farms) and processors (slaughterhouses, dairies) to screen more than 50 authorized antibiotics.
Our long experience and good market position in this field has allowed us to identify a great opportunity to develop an innovative system (e-Reader) that transforms a laboratory assay (lab in-a-box concept) in an easy, fast and economic solution adapted to antibiotics self-controls for all food operators (farmers, dairies, slaughterhouses,). e-Readers prototype complies with the EU legislation and is being validated by 3 reference laboratories in Europe.
This project will place ZEULAB in the forefront of a potential market of millions of tests that will allow our company to grow at least 3-5 times (9-15 M and 80% of exports) in the next 5 years. This growth is based on the 600.000 EU farmers and 40.000 food plants that should implement self-controls according to EU Commission policy from farm to fork.";71429;50000;H2020-SMEINST-1-2014;SME-1;ZEULAB SL;ES;;; 196663;673651;IPHYC-H2020;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;EU market research for an innovative algae based tertiary wastewater treatment system;1/05/2015;31/10/2015;;"Industrial Phycology (I-PHYC) has developed a wastewater treatment (WWT) process that can meet increasingly stricter discharge consents for the concentration of nitrogen (N) and phosphorus (P) in wastewater (WW) effluents. Elevated levels of N & P are linked to detrimental environmental events e.g. eutrophication. WWT operators require a treatment process that is able to remove nutrients in an energy efficient manner which current technology cannot meet.
I-PHYCs novel patented treatment process uses microalgae (MA) to remove nutrients from WW effluents. MA reproduce rapidly when sufficient nutrients, light and CO2 are supplied. The MA consume the nutrients of the WW until exhausted producing a clean effluent that meets new EU consents and allows the operator to meet its statutory commitments while avoiding financial penalties. The biomass is retained for reactor seeding or harvested for valorisation e.g. anaerobic digestion of biomass to produce electricity. I-PHYC has estimated that valorisation will offer a payback period on CAPEX of 2.5-3 years, with significantly reduced OPEX.
The process has been validated by I-PHYC in a recent field trial (late 2013) at Avonmouth WWT, UK. The field trial was based on a 1 m3 system which replicated all the functions of a commercial scale system. Results from the trial demonstrated a reduction in the tertiary treatment effluent concentration of P and ammonia by >70% and COD by>30%. Currently, I-PHYC is trialling a 20 m3 system onsite at a municipal WWT works with our strategic partner Wessex Water.
I-PHYC is applying for funds to undertake a market study to determine the best approach for entering the EU market for P removal in WW effluent by: marketing the solution to the various firms in the EU operating under different local regulations; determining market size, growth trends and competition; and how to price its innovation. This funding will help I-PHYC to develop the strategy required to bridge the market adoption gap";71429;50000;H2020-SMEINST-1-2014;SME-1;INDUSTRIAL PHYCOLOGY LIMITED;UK;;; 196690;664629;MIA;SIGNED;H2020-EU.4.a.;WIDESPREAD-1-2014;H2020;Multidisciplinary Institute for Ageing;1/06/2015;31/05/2016;;"This project describes a teaming partnership between the University of Coimbra (UC) (partner in a low-performing country) and the University of Newcastle (UNEW) (partner in a high-performing country) to create, in Coimbra, a new Centre of Excellence in Ageing Research - the Coimbra Multidisciplinary Institute of Ageing (MIA). This flagship project for the Centro Region of Portugal is aligned with the regional RIS3 and will be coordinated by the regional authority CCDRC (strategic coordinator) and by UC (operational coordinator).
The Newcastle University Institute for Ageing (NUIA) is one of the largest and longest established institutions in translational ageing research worldwide. In this teaming project, NUIA is supported by two further world-leading centres in translational ageing research; the University Medical Center Groningen (UMCG) and the Mayo Clinic Robert and Arlene Kogod Center on Aging.
European Member states are committed to increase human healthy life expectancy by two years on average by 2020. Present increases in healthy life expectancy are largely due to increasing differences in ageing rates between member states, regions, communities and individuals. This massively worsens socioeconomic inequalities. Recent progress in understanding the mechanisms of ageing suggests that social, lifestyle, nutritional and pharmaceutical interventions can, effectively, reduce these differences by targeting the faster ageing members of the population.
The overall objective of the new Centre for Excellence is to improve health and wellbeing of an ageing population. It will gain a forefront position in ageing research and develop, validate and deliver interventions that can improve human healthy life expectancy. It will train young researchers and engage the public in support and implementation of innovative good practices. MIA will be integrated into the Ageing@Coimbra Vitality Campus, a European Innovation Partnership on Active and Healthy Ageing Reference Site.";499232,75;499232,75;H2020-WIDESPREAD-2014-1;SGA-CSA;COMISSAO DE COORDENACAO E DESENVOLVIMENTO REGIONAL DO CENTRO;PT;"UNIVERSITY OF NEWCASTLE UPON TYNE;INSTITUTO PEDRO NUNES ASSOCIACAOPARA A INOVACAO E DESENVOLVIMENTOEM CIENCIA E TECNOLOGIA;UNIVERSIDADE DE COIMBRA;ACADEMISCH ZIEKENHUIS GRONINGEN";"UK;PT;NL"; 196657;666427;ADD-ON;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014;H2020;A demonstration plant of enhanced biogas production with Add-On technology;1/03/2015;31/05/2017;;"The overall goal of the business innovation project is to commercialise Ductors proprietary nitrogen-control technology that has the potential to revolutionise the economics of biogas production. Our technology, based on cumulative R&D investment of over 4 m, is capable to remove over 60% of nitrogen from several organic waste materials. This enables broader utilisation of high-nitrogen organic waste such as chicken manure in biogas production, which allows millions of tons of unexploited organic waste in Europe to be processed cleanly, economically and efficiently. Via Ductors technology, biogas producers can, for example, increasingly replace maize silage with chicken manure as biogas feedstock. With this approach alone, the European biogas producers could achieve a combined \1 b improvement in their profitability while also cutting CO2 emissions by 1.5 million tons and releasing 811,000 hectares of field for socially and environmentally more sustainable use such as food production.
During the project, we will scale up our current pilot equipment to industrial scale together with our partner, a European biogas producer. We will also confirm the expected benefits of our technology in industrial environment and optimise the technology for a broad range of feedstocks to cater all customer needs.
The project will enable fast commercialisation of our product within the first targeted customer group: the existing small and mid-sized biogas plants in Germany, the largest biogas market in the world. Within this segment, our primary targets are appr. 2,000 biogas plants that currently utilise maize silage in biogas production. Confirming our value proposition in this customer group enables us to develop our technology to meet the requirements of larger biogas plants as well. The targeted final outcome of the project is to build a comprehensive product portfolio for both existing biogas plants and new biogas plant projects in all size categories globally.";2021077,5;1414754,25;H2020-SMEINST-2-2014;SME-2;DUCTOR OY;FI;;; 196656;674364;ZEBCOM;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Zero Emission Robot-Boat for Coastal and Inland Water Monitoring;1/06/2015;30/11/2015;;"The project aims to develop an eco-innovative product: a zero emission autonomous (unmanned) robot-boat system intended for use as a monitoring station for quality & quantity of surface waters. The proposed innovative product (system) aims to contribute to solving two important issues:
-The (unprecedented) need of high quality, real-time information/data on water environment related primarily to the Increasing climate change uncertainty, and to protection of the environment
-The need of low-carbon, low-cost, effective vessels operating in inland and coastal water
The positioning of the present business innovation project can be estimated as being at TRL7 system prototype demonstration in operational environment.
The robot-boat system is intended to be operated as an unmanned apparatus; having onboard computer and a large-range radio-telemetry system for real-time transfer of data for desktop and web-applications; with a large carrying capacity and special shape, to carry onboard various measurement equipment ; incorporating a number of innovative solutions.
Main objective of project Phase 1 is the development of a Feasibility study including a business plan. A comprehensive analysis of basic Technological factors, Economics, Marketing and Financial study, Legal requirements, Operational conditions will be carried out.
The use of the system as an autonomous monitoring unit can provide low-cost, efficient and routine monitoring of the aquatic environment, this way providing significant impact on EU water sector. Reliable data from such observations are of crucial importance to understanding and adaptation to climate change, as well as to respond to unprecedented burden on water resources, needed not only for safe drinking water, but also to support agriculture, energy, transportation, manufacturing, and civil infrastructure.
It can also help coastal and catchment communities to adapt to climate change, and react to flood hazards and environmental threats.";71429;50000;H2020-SMEINST-1-2014;SME-1;CORES EOOD;BG;;; 196645;661373;VisHipMem;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;At first glance: How saccades drive communication between the visual system and the hippocampus during memory formation;1/05/2015;30/04/2017;;"Information processing in the human brain depends on the exact timing of neuronal activity. Duty cycles, defining favorable states of activity within the phase of a neuronal oscillation, have been shown to coordinate information processing in the visual domain (Jensen & Mazaheri, 2010) and the formation of new memories (Buzsaki, 2010). While there is little doubt about the interaction between these two domains, the underlying mechanisms are as of yet unclear. The aim of the present proposal is to understand the mechanisms supporting human memory formation by investigating the joint inter-regional coordination of visual and memory-related brain regions. Recent evidence suggests that saccadic eye movements modulate hippocampal oscillations in non-human primates during memory formation (Jutras et al., 2013) and also influence the phase of visual oscillations (Ito et al., 2011; 2013). It is hypothesized that the coordination of these brain areas during information transfer can be unraveled by incorporating saccadic eye movements adjusting the phase of visual and hippocampal oscillations. In particular, it is hypothesized that neuronal oscillations following saccades are instrumental to synchronize visual cortex and hippocampus activity such that visual information is successfully encoded. Oscillatory synchronization in the 5-12 Hz theta/alpha band is expected to establish the functional connectivity between the visuo-hippocampal regions, whereas gamma band activity (30-100 Hz), phase-locked to the theta/alpha oscillations reflects the actual information transfer (Lisman & Jensen, 2013; Jensen et al., 2014). The aim of this research plan is to test these hypotheses directly by using a combination of neuromagnetic (MEG), neuroimaging (fMRI) and behavioral (eye tracker) recordings in a memory paradigm.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 196637;651407;Ultroslag;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;A new integrated sustainable processing system for metal from slag recovery with higher technical, economic, energy and environmental performance than existing recovery processes.;1/10/2014;31/03/2015;;"Slag is a by-product of metal smelting, and ~3.5 million tpa are produced globally in refining Non Ferrous Metals (NFM) and making alloys. Slag contains impurities and forms a protective crust of non-metallic & metallic oxides, and contains significant free & alloyed metal (from 10 to 70% by weight). While slag can be used as aggregate, there are increasing concerns over leaching of heavy metals into water courses from using these materials in civil engineering. While some metal can be recovered by re-melting slag (at very high temp), this is extremely expensive with very high energy burden which often makes recovery un-economic, but necessary. Landfill of slag is increasingly not an option. Our idea is to use a relatively new technology called implosion to selectively break down and separate non-metallic components of slag from metallic particles. This will be combined with ultrasonic vibration sieving for accelerated recovery of metal from the finest fraction. This novel technology was originally developed to recycle waste glass by reducing it to fine sand, with uniform size and no sharps compared to normal crushing techniques. This technology has not been applied commercially to other materials. Benefits to partners, endusers & society could be:
Rapid recovery of more metal from slag at relatively low cost
Strategic control of metal recovered rather than losing control thro export to low cost economies
Enable smelters to recycle slag in-house, increasing their Value Add while reducing recycle-miles
97% energy saving thro low cost mechanical separation rather than very high temp. melt recycling
Huge cut in carbon emissions from thermal energy saved and recycle-miles saved

The ultimate goal is to launch a new process in the market, through an innovative application of a relatively new technology to selectively break down the non-metallic components of slag from the metallic particles.";71429;50000;H2020-SMEINST-1-2014;SME-1;ULTROMEX LTD;UK;;; 196707;636573;CREATE;SIGNED;H2020-EU.3.4.;MG-5.3-2014;H2020;Congestion Reduction in Europe : Advancing Transport Efficiency (CREATE);1/06/2015;31/05/2018;;"CREATE addresses the task Tackling Urban Road Congestion, taking a long-term view of how this can be achieved, especially in cities experiencing rapid growth in car ownership and use. It deals with most of the issues set out in the recent Urban Mobility Package.
Objectives:
Rigorously and systematically develop practical definitions of urban road congestion and of network performance, and identify factors influencing conditions in different cities.
Work with Western European (WE) cities that have succeeded in decoupling traffic growth from economic growth, to analyse quantitatively the objective factors which have contributed to this, and the qualitative factors which have enabled a policy evolution from supporting traffic growth to encouraging sustainable mobility.
Develop concrete guidance and provide capacity building for cities in Central and Eastern Europe (CEE), and the EuroMed region, enabling them to move rapidly to develop a feasible, effective and deliverable Sustainable Urban Mobility Plan (SUMP).
Anticipating future pressures on city transport systems (congestion and overcrowding), to investigate how new transport technologies might increase transport efficiency, and how non-transport technologies and changes in business and social practices could reduce pressures on transport systems.
These objectives will be achieved by:
Analysing congestion and network performance data provided by INRIX and WE cities.
Using detailed household travel data from repeat surveys in WE cities since the 1970s/1980s and complementary data on network, economic and demographic conditions; and documents setting out historical policy development.
Preparing detailed guidance and training for our CEE cities, which will then be delivered to a much larger set of cities.
Working with leading technology providers, businesses and futurists, to explore what options there might be to provide high quality mobility in cities facing increasing population and employment.";3981461,25;3870146,25;H2020-MG-2014_TwoStages;RIA;UNIVERSITY COLLEGE LONDON;UK;"EUROCITIES ASBL;TRANSPORT FOR LONDON*TFL;VECTOS (SOUTH) LIMITED;ADANA METROPOLITAN MUNICIPALITY;EUROPEAN INTEGRATED PROJECT;FONDATION NATIONALE DES SCIENCES POLITIQUES;SENATSVERWALTUNG FUR STADTENTWICKLUNG;MUNICIPIUL BUCURESTI;UNIVERSITAET FUER BODENKULTUR WIEN;INSTITUT D'AMENAGEMENT ET D'URBANISME DE LA REGION D'ILE DE FRANCE;KOBENHAVNS KOMMUNE;TALLINNA LINN;GREATER AMMAN MUNICIPALITY;COWI A/S;CITY OF SKOPJE;TECHNISCHE UNIVERSITAET DRESDEN;INRIX UK LIMITED";"BE;UK;TR;RO;FR;DE;AT;DK;EE;JO;MK"; 196662;673917;MLSYSTEM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;MLSYSTEM - heatable, integrated photovoltaics with insulated glass units;1/05/2015;31/10/2015;;"Main objective of this proposal is to launch a novel multifunctional window (MLSYSTEM), which is a glazed insulating glass unit integrated with semi-transparent photovoltaics (panels of all generations) on the EU market. It was developed by a R&D department of ML System. Current available solutions can not be full-competitive to MLSYSTEM. There are PV panels, PV mounting systems, heatable insulated glass units, radiators. The main innovative feature of our technology is a cost-effective integration of properties of all these products. Thanks to 3rd generation solar cells application, higher aesthetic, transparency and better power reduction parameter in relation to any PV technology used so far on Building-Integrated PV sector could be achieved.
We intend to contribute to solving one of the Europeans main problem, as well as one of the real estates market problems. Buildings are the biggest primary energy consumer and Europes CO2 emitter. 30% of energy consumed in buildings is used unnecessarily or inefficiently. 30-50% of energy loss is attributed to air leakage and heat transfer. One of the main sources of these losses are windows. Our innovative solution allows for environmental-friendly electrical energy production and thermal energy transfer into a heated room simultaneously manner and is much cheaper than competing solutions. At least 39,000 of tons reduction of CO2 emissions will be achieved every year. Moreover the European efficiency-related construction market is expected to double to 140 billion by 2020 from 70 billion in 2011 - we are ready to exploit this business opportunity.
Feasibility study will enable us to verify the technological feasibility and economic viability of launching MLSYSTEM on different EU markets, which will contribute to solving the aforementioned problems. PHASE I is only the beginning and we believe it will lead to PHASE II. This will enable us to identify resources needed for commercial implementation of our technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;ML SYSTEM SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA;PL;;; 196703;652171;Poul-AR;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Poultry manure valorization;1/10/2014;31/03/2015;;"Poultry farming worldwide is among the largest sectors of animal husbandry for food production. As with other bio-farming activities poultry farming is associated with manure production. In contrast with other manure types poultry manure is very rich in nutrients as nitrogen & phosphorus and also in organic material.

The project applies eco-innovative principles and technologies and thus opens a sustainable route to nutrient recovery and energy efficiency for poultry manure. The approach makes use of subsequent biological and physical treatment steps. The 1st step in the process consists of a biological ammonification step in which organic nitrogen is biologically converted into ammonia. A 2nd step removes the ammonia present in the broth via stripping with air. The ammonia is subsequently fixated with sulphuric or nitric acid as an ammonium salt (sulphate, nitrate) to produce the desired fertilizer. The residual organic fraction of the manure can now be readily digested afterwards, to produce biogas which in turn can be used as a source of heat or electricity.

The project proposes an integrated biological approach for the pre-treatment and valorisation of poultry manure. The liberation and fixation of nitrogen as nutrient is optimized and the product consists of a valuable ammonium salt directly applicable as fertilizer. The residue of the de-ammonification allows for a variety of post treatment methods. As a spinoff, additional amounts of valuable nutrients can be liberated and efficient bioconversion of the organic fraction comes within reach, adding to the potential of the business case. Meanwhile there is a significant environmental gain as the emission of ammonia into the atmosphere associated with current practices is completely prevented, which is especially beneficial for vulnerable and sensitive areas and water bodies. Up to 11.25 kg ammonia per ton poultry manure are released into the atmosphere when raw poultry manure is used for land fertilization.";71429;50000;H2020-SMEINST-1-2014;SME-1;COLSEN, ADVIESBURO VOOR MILIEUTECHNIEK BV;NL;;; 196636;650515;Lt-AD;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Low-temperature anaerobic digestion treatment of low-strength wastewaters;1/11/2014;30/04/2015;;"NVP Energy presents the first to market, high-rate anaerobic digestion (AD) technology that successfully treats low strength wastewater (WW) at ambient temperatures (< 20C). The low-temperature (Lt-AD) process provides a novel solution to Food and Drinks industrial sectors producing large WW volumes requiring treatment. The sector of interest is milk treatment and processing, a growing market producing over 367 billion litres annually; WW is typically treated using conventional aerobic processes resulting in high sludge yields, requiring a large footprint on-site and a heavy reliance on fossil fuels. Lt-AD produces negligible sludge volumes, has a compact design, requires no heat input or biogas recirculation, and produces effluent of urban wastewater directive (UWWD) standard (< 125 mg/L COD) without post-aeration. A typical dairy processing plant producing 5,000 m3 WW per day can save 97% on operational costs by replacing aerobic treatment with Lt-AD, and generate annual biogas revenue of 616,266. The technology's low temperature operation allows for 100% of the biogas produced being available for reuse or resale. The process also has a high impact on environmental savings through reduced greenhouse gas (GHG) emissions, lowered thermal energy and fossil fuels requirements.
This feasibility study will allow NVP Energy to build relationships with potential users, assess EU market opportunities, and determine resources required to deliver a full WW treatment solution in terms of technical, legal, environmental, marketing, sales, manufacturing or service capabilities. The outcomes will be the securing of a demonstrator industrial site, achieving an in-depth understanding of the EU market, building concrete relationships with collaborators and ultimately producing an all-embracing business plan. Phase 2 delivery of Lt-AD as a full-scale treatment solution for low strength WW producers will be critical to delivering this technology throughout Europe and beyond.";71429;50000;H2020-SMEINST-1-2014;SME-1;NVP ENERGY LIMITED;IE;;; 196589;659193;Evolutionary Neurogenomics;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The impact of recent retrotransposon invasions on the evolution of human neural gene expression;1/06/2015;31/05/2017;;Throughout evolution, primate genomes have been under attack by different classes of retrotransposons, retrovirus-derived mobile DNA elements. As a result, an astonishing ~50% of the human genome is derived from many types of retrotransposons. I previously showed that primate-specific retrotransposon invasions are restricted by primate-specific KRAB zinc finger proteins. These findings suggest that through recruitment to thousands of new genomic locations, KRAB zinc finger proteins have become intimately integrated into pre-existing gene regulatory pathways. Retrotransposons are an important source for evolutionary novelties, but the impact of thousands of human-specific retrotransposon-KZNF regulatory modules on the evolution of human gene expression patterns is unknown. There is increasing evidence that retrotransposons become reactivated during neural differentiation, suggesting that neuronal gene-regulatory networks may be extra sensitive to retrotransposon insertions. Furthermore, new retrotransposon insertions may hold clues to the mechanism of human disease: Even when retrotransposons are efficiently silenced in health, they may become aberrantly activated by changes in DNA methylation observed in neurological diseases and cancer. Using a previously established human and non-human primate stem cell cortical neuron differentiation assay, I will identify, validate and functionally test neurodevelopmental genes that have come under the control of retrotransposons. This will address the impact of recent waves of retrotransposon insertions on the evolution of human neural gene expression patterns and opens up the exploration of how new retrotransposon insertions may be correlated to human neurological disorders. The Marie Sk?odowska-Curie individual fellowship will provide the opportunity to establish my research group in Europe and re-integrate in Dutch and EU networks, as well as allow me to achieve my professional development training goals.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITEIT VAN AMSTERDAM;NL;;; 196644;659749;InterAct;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;INTerdisciplinary ACTion for accelerating RD on and implementation of solid sorption heat pumps;1/07/2015;30/06/2016;;"INTERACT: Interdisciplinair action for accelerating R&D on and implementation of solid-sorption heat pumps aims to advance the introduction of solid-sorption heat pumps to the market and to expand their application to industrial process heating as well as heating in buildings. According to the International Energy Agency (IEA), energy efficiency is the first option for reducing carbon dioxide emissions before renewables and biofuels. Solid-sorption heat pumps are a very promising option for energy efficiency in heating and cooling, which accounts for 50% of our final energy use.
Three project objectives have been defined:
1. to develop solid-sorption reactors with a power density exceeding 1 MW/m3;
2. to develop a strategic market plan in cooperation with manufacturers and end-users containing the required technical specifications for solid-sorption heat pumps and an approach to overcome the main non-technological challenges;
3. to maximize impact of this & other related solid-sorption heat pump project results.
This work will enhance the research and innovation skills of the applicant, providing him with collaborative international research experience at the highest level and new career perspectives. The collaborative research undertaken is in the overall area of the Rational Use of Energy and Renewable Energy.";97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 196625;644742;LEO;SIGNED;H2020-EU.2.1.1.6.;ICT-29-2014;H2020;Low-cost / energy Efficient Oleds for lighting;1/01/2015;31/12/2017;;LEO ambitions innovative manufacturing concept & routes towards high performance bendable and low cost OLEDs for general and mood lighting, merging conventional and proven technologies with disruptive approaches (e.g. substrate, architecture, hybrid processing, layouts). R&D activities will be ramped-up from lab scale feasibility to pilot line scale demonstration, delivering show off lighting systems with the help of external lighting manufacturers (Artemide, Technology Luminaires). The project targets the introduction of novel materials combinations (conformable & functionalized metallic substrate, Indium free electrodes and solution-processable organic materials) in large area colour tuneable top emission white OLEDs. Besides dry processing of large area tandem stacks (> 500 cm2), a novel hybrid process flow will be set-up whereby stacks will be wet processed up to the 1st emitting layer prior device completion by dry processing. With common and innovative building blocks (substrate with integrated interconnecting, 80 % transparent top electrode, 1E-6 g/m?/day WVTR scratch resistant thin film encapsulation, 50 % out-coupling efficiency), these two complementary approaches will lead to demonstrations of large area warm/cold white macro-pixels and hybrid full colours RGB OLEDs. LEO will address cost reduction at materials and process levels which represent more than 80% of the total cost of OLED lighting devices, according to a recent study. Leverage will be sought at mostly all layers of the stack with cost impacts at materials, device and system scales. In order to combine necessary and complementary capacities to reach its ambitious goals, LEO has gathered all stakeholders of the OLED lighting device fabrication value chain (except equipment supplier), including substrate and organic materials suppliers (AC&CS, Cynora), an OLED manufacturer (OSRAM OLED) and recognized research centres in the field of OLEDs and life cycle analysis (CEA, CNR, Gaiker).;3986262,5;3986262,5;H2020-ICT-2014-1;RIA;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;"ADVANCED COATINGS & CONSTRUCTION SOLUTIONS SCRL;CYNORA GMBH;OSRAM OLED GMBH;CONSIGLIO NAZIONALE DELLE RICERCHE;OSRAM OPTO SEMICONDUCTORS GMBH;FUNDACION GAIKER";"BE;DE;IT;ES"; 196597;674292;SmartRay;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Smart Large Scale Radio Technology for the Tactile Internet;1/06/2015;31/10/2015;;For future mobile wireless services and applications, network operators must deliver exponentially increasing capacity, carrier grade reliability, and efficiency without increasing CAPEX and OPEX significantly. Airrays has developed game changing radio technology for the 4th and 5th generation mobile communication networks that meets these challenges. By using software-controlled beams, Airrays radio units direct signal energy from a cellular base station to exactly where it is needed, e.g., at individual users or hotspots. Compared to state-of-the-art, the technology provides up to 10-fold increased capacity, 10-fold reduced energy consumption, and 10-fold increased reliability, as well as reduced deployment and operational cost of up to 50%. The objective of the innovation project SmartRay is to commercialize Airrays advanced antenna technology and to successfully enter the mobile network infrastructure market. Airrays will position themselves initially as component supplier to established infrastructure vendors and antenna manufacturers and, at a later stage, leverage its technology advantage to become vendor of radio units and deliver directly to network operators. This ambition is in line with current disruptive trends in the 4G and 5G infrastructure market where small vendors establish themselves alongside large established players. Through product development as well as successful commercialization Airrays will explicitly strengthen the European communication infrastructure sector. SmartRay Phase 1 will among others conduct a complete FTO analysis, provide detailed product roadmap, and develop a concrete go-to-market strategy to identify an initial market segment to address.;71429;50000;H2020-SMEINST-1-2014;SME-1;AIRRAYS GMBH;DE;;; 196624;644631;ROLL-OUT;SIGNED;H2020-EU.2.1.1.1.;ICT-03-2014;H2020;High-performance, Flexible, AUTOnomous Systems manufactured with Unique, Industrial ROLL-to-roll equipments;1/01/2015;31/12/2017;;"This R&I action will focus on optimally combining traditional roll-to-roll (R2R) compatible fabrication technologies such as printing with unique R2R sputtering, ALD and heterogeneous integration for flexible, thin, large-area electronics applications. It is seen that the different R2R fabrication methods all have their strengths and weaknesses such that using a cost-performance-optimized combination of them for a single production will enable new levels of applicability for TOLAE devices for mass markets. The goal of the ROLL-OUT project is to create a multi-purpose technology for, thin, large-area, high-performance, smart, and autonomous systems comprising of integrated circuits (based on metal-oxide thin-film transistors), sensors, and electronics. They will be utilized in advancing the packaging, automotive interiors and textile industries beyond their traditional scope. The key features are high-performance circuits and components. To fabricate high-performance circuits, the project intends to use novel, hybrid, moderate-temperature, roll-to-roll processes, namely sputtering, Atomic Layer Deposition (ALD) and screen-printing on thin, flexible, large-area substrates. This will enable enormous value addition to the products of European industries without adding any significant extra cost.

ROLL-OUT has 5 research organizations (RO) and 5 industrial partners (IND). The action has 6 work-packages (WPs) of which 3 are led by ROs and 3 by INDs. The technology development WPs are led by ROs and demonstration and exploitation WPs are led by INDs. The action intends to create 3 tangible industrial smart, autonomous system demonstrators that will be validated by the industrial partners in accordance with standard testing protocols.

The action seeks EU funding of 3.66M for a period of 36 months. 356,5 person-months will be dedicated to the work. The consortium consists of partners from 7 EU member states with complimentary expertise essential for the action.";3658942,5;3658942,5;H2020-ICT-2014-1;RIA;TEKNOLOGIAN TUTKIMUSKESKUS VTT;FI;"LOGOPLASTE INNOVATION LAB LDA;Uppsala universitet;FOV FABRICS AB;POLYTEKNIK AS;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;MAIER SCOOP;UNINOVA-INSTITUTO DE DESENVOLVIMENTO DE NOVAS TECNOLOGIAS-ASSOCIACAO;PICOSUN OY;FUNDACION CIDETEC";"PT;SE;DK;DE;ES;FI"; 196634;649720;CEPPI 2;SIGNED;H2020-EU.3.3.7.;EE-08-2014;H2020;Coordinated energy-related PPIs actions for cities (CEPPI);1/04/2015;31/03/2018;;"CEPPI aims to build capacity in cities on how to achieve more sustainable energy solutions through a pro-innovation procurement approach (PPI) & to demonstrate this by selectively intervening in scheduled public tenders. The interventions will involve 5 cities with different economic & political situations & provide the case-based evidence for replication by others.
The scale of energy demand in European cities is huge & as an ever greater percentage of citizens are living in urban areas. Some of the biggest city authorities consume over 1000GWh of energy every year to run their operations & it is estimated that the energy consumption of the whole city (the wider sphere of influence) could be at least 50 times that of the city authorities alone. Much of the investment in energy efficiency & renewable energy production has been based on project funding & there is an underexploited opportunity to achieve more systematic and progressive improvements through embedding PPI methodologies within the ongoing processes for the procurement of energy-intensive goods & services. CEPPI will demonstrate, through an action learning process, how forthcoming public tenders can be influenced to achieve a more sustainable energy outcome & build capacity amongst management & procurement professionals.
The project will build on established relationships that have been developed between the five participating cities (Birmingham, Budapest, Castellon, Valencia, Wroclaw) through the Climate KIC. They will be mentored (by leading PPI and sustainable energy experts) through an action learning process that will build the short term knowledge and PPI capacity to reduce annual energy consumption by at least 33GWh. Energy & procurement foresight activities will provide the strategic direction to become both procurement & technological leaders for sustainable, energy-efficient cities. At least 80 individuals across the 5 cities will be introduced to innovation procurement methods.";1294808;1294808;H2020-EE-2014-3-MarketUptake;CSA;BIRMINGHAM CITY COUNCIL;UK;"OPTIMAT LIMITED;JERA CONSULTING LIMITED;AYUNTAMIENTO DE CASTELLON DE LA PLANA;BUDAPEST FOVAROS ONKORMANYZATA;Wroclawskie Centrum Badan EIT+ Sp z o.o;FUNDACION DE LA COMUNITAT VALENCIANA PARA LA PROMOCION ESTRATEGICA EL DESARROLLO Y LA INNOVACION URBANA;ICLEI EUROPEAN SECRETARIAT GMBH (ICLEI EUROPASEKRETARIAT GMBH)*;STEINBEIS GMBH & CO. KG FUER TECHNOLOGIETRANSFER";"UK;ES;HU;PL;DE"; 196688;664482;HiLASE CoE;SIGNED;H2020-EU.4.a.;WIDESPREAD-1-2014;H2020;HiLASE Centre of Excellence;1/06/2015;31/05/2016;;"'Czech Republic has invested 32M in the construction of an advanced, 'next generation' laser, HiLASE, at Doln B?e?any in Central Bohemia Region. HiLASE will be commissioned in 2015 as a major laser facility of the Czech Institute of Physics (IoP) with the potential to be an outstanding science and technology asset for the region and for Europe. This Teaming Action will transform HiLASE from a state-of-the-art laser into a Centre of Excellence, serving a broadly based scientific and industrial user community, stimulating innovation and developing the technology itself to ensure that the Centre is sustainable and competitive in the long term. This will enable the Centre to fulfil its role as a driver of scientific excellence and a generator of economic impact, thus raising the region's innovation performance.
The IoP will team with the Central Laser Facility (CLF) at STFC's Rutherford Appleton Laboratory in Oxfordshire, UK. CLF is widely regarded as a world leader in both the delivery of advanced laser facilities to a large and diverse international user community, and in the development of the 'next generation' laser technology which is at the heart of this proposal. CLF staff will be assisted by STFCs Business and Innovations Directorate who will identify innovation opportunities and drive the transition from academic experiments to industrial applications.
Partnership with STFC will ensure that the Centre is 'up and running' as a new user facility as quickly as possible, that opportunities for innovation and exploitation are identified and developed, and that a cutting edge facility enhancement programme is delivered efficiently, on time and with the best value for money. This will ensure the success of the Centre for the duration of the Teaming Action, the competitive edge of its facilities and its sustainability into the future.'";494831;494831;H2020-WIDESPREAD-2014-1;SGA-CSA;FYZIKALNI USTAV AV CR V.V.I;CZ;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;UK; 196701;673802;CORSAIR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Increasing the quality mindset of COnstruction workers involved in building Refurbishment processes through a Software Application capable of using among others visible or InfraRed pictures of defects;1/06/2015;30/11/2015;;Europe aims at fully decarbonizing its economy by 2050. It requires the in-depth renovation of existing buildings to make them much more energy efficient through high quality refurbishment processes (design, construction and maintenance): high quality processes are needed to narrow down to-days measured energy performance gaps between what is foreseen for the refurbishment by design and the real performance of refurbished buildings when used. Several information systems are available today to help the construction value chain improving its daily quality. But none of these software products allows any player of the refurbishment value chain sharing Notes for a given project in a collaborative manner, thus handling any type of the data (construction plans, numerical simulations, images, ) that are used to meet quality standards when refurbishing. BLOCKBASE provides any small expert company involved in refurbishment process with the low entry cost, easy-to-use BulldozAIR software suite, accessed under a SaaS (Software as a Service) purchase mode, and available on-line in the Apple, Microsoft and Google operating systems. Blockbase aims at expanding its market share by showing how BulldozAIR can handle any image data streams (3-D scans at refurbishment design, visible or infra-red camera images at construction and maintenance levels), thus helping players share the knowledge securing a high quality field work during refurbishment. The use of images indeed enhances self-validation by field players of the quality of their own building construction or maintenance activities on a daily basis. Construction workers or maintenance operators will thus always be in a position to correct for errors on the spot, possibly in direct interaction with the refurbishment design bureaus. It is to address the construction world market that a set of demonstration activities are needed in several European member states to validate the product robustness on real construction projects.;71429;50000;H2020-SMEINST-1-2014;SME-1;BLOCKBASE;FR;;; 196635;649796;OPTi;SIGNED;H2020-EU.3.3.1.;EE-13-2014;H2020;OPTiOptimisation of District Heating Cooling systems;1/03/2015;31/10/2017;;"With a user-centric design, we will contribute to next-generation District Heating & Cooling systems

The OPTi project aspires to create a long-lasting impact by rethinking the way DHC systems are architected and controlled. The overarching goal is to create business benefit for the industry as well as to ensure optimal end-consumer satisfaction.
OPTi will deliver methodologies and tools that will enable accurate modelling, analysis and control of current and envisioned DHC systems. The methodology will be deployed both on a complete system level, and on the level of a building(s).
OPTi will treat the DHC system as a system subject to dynamic control, and will treat thermal energy as a resource to be controlled for DHC systems towards saving energy and reducing peak loads. This will lead to the most environmentally-friendly way of utilizing energy sources, thus reducing the reliance on additional boilers running on oil and/or electricity and overall providing a socio-economically sustainable environment.

OPTi will help energy companies to operate both todays and future DHC systems in an optimal way:
System level: We envision opportunities for SMEs to provide new services/solutions
House level: More intelligent home DHC control systems like remote control and the consumer virtual knob
General: We foresee that the OPTi framework will enable engineers to design and plan DHC

Lule Energi AB invests 45 MEUR (2014-2018) in their DHC to meet the requirements from the expanding Lule City. This will enhance the system and allow for new solutions to be deployed and is directly beneficial for this project.
Saving 30% of energy for water and heating on a system level
Saving 30-40% of peak consumption on houses/clusters of houses
Promote ways of operating todays and future DH/DC systems in more optimized and environmentally friendly way including alternative energy sources and energy storage methods";2100130;2100130;H2020-EE-2014-2-RIA;RIA;LULEA TEKNISKA UNIVERSITET;SE;"OPTIMATION AB;TWT GMBH SCIENCE & INNOVATION;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;SAMPOL INGENIERIA Y OBRAS S.A.;IBM India Private Limited;LULEA ENERGI AB;ATHENS UNIVERSITY OF ECONOMICS AND BUSINESS - RESEARCH CENTER";"SE;DE;ES;IN;EL"; 196661;672124;SEEABLE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;An Innovative ICT Solution for Providing Bespoke Safety and Health Training to Workers in the Construction and Transportation Sectors.;1/05/2015;31/10/2015;;"An ICT solution for repurposing digital data available from Building Information Modelling (BIM) in order to improve Safety & Health (S&H) training and implementation. Every year, thousands are fatally injured and millions are seriously injured in accidents occurring in the workplace. The risk to workers is significantly higher in the construction and transportation sectors.

BIM captures all digital data relevant to a building or piece of infrastructure over its lifetime. The use of BIM is becoming mandatory for public procurement projects in Europe and will generate a wealth of digital data. This presents a major opportunity for disruptive business ideas and we have identified the possibility to repurpose this data so that we can provide interactive and context-relevant S&H training via 3D applications.

We, Severn Partnership, want to carry out a feasibility study around our concept for repurposing data from BIM. We will develop an application to deliver S&H training to railway workers. It will employ pedagogic strategies in a games environment to demonstrate enhanced learning. We will test it in a classroom environment with real learners and benchmark it against current methods of teaching (presentations, course notes, Q&A).

The feasibility study will explore the market landscape across different sectors utilising BIM, especially within construction and transportation. A survey of executives from industries in these sectors will identify operational requirements. This will aid the creation of an exploitation strategy and business plan.

The overall aim is to develop a new ICT service that improves the effectiveness of S&H training and ultimately saves lives by preventing accidents in the workplace.";71429;50000;H2020-SMEINST-1-2014;SME-1;THE SEVERN PARTNERSHIP LIMITED;UK;;; 196700;673674;REGHA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Medical device combining viscosupplementation with pharmacological active molecule to regenerate cartilage in degenerative or traumatic osteoarthritis.;1/05/2015;31/10/2015;;To develop and commercialize a medical device (MD) that can effectively respond to unmet therapeutic needs in the treatment of osteoarthritis (OA), namely degeneration of cartilage. OA is a huge medical, social and economic burden worldwide. This therapeutic approach by local injection in the join will be a breakthrough innovation for OA therapy. The expected product is a combination of HA viscosupplementation with our pharmacological active patented molecule stimulating chondrocytes proliferation, the only cells producing and maintaining the cartilage matrix. Cartilage does not contain blood vessels, therefore this requires the product be administered locally. Our innovative project will provide a MD allowing an easily, affordable and cheaper solution than surgery for the therapeutic treatment of OA and should have a positive impact on the economic and social cost of OA. The commercial potential is one of the highest in the field of health because there are currently no specific therapeutic molecules on the market for this frequent degenerative disease. Users are to be found in the aging population and people with joint injuries in need for a regenerative therapy. The feasibility assessment undertaken in Phase I will be the completion of the technical feasibility studies for combining our molecule with HA in an injectable solution, for formulation and production of the combined products including validation of its biological activities and the selection of manufacturing partners for the MD final production (processes for production of the final GLP batch and packaging will be assessed) allowing the subsequent planning & implementation of manufacturing for clinical phases. The commercialization plan will be refined using detail analysis of potential users, ROI for the different business cases and the best strategy for commercialization In Europe altogether 10%-15% of adults over 60 have some degree of OA globally estimated concerning more than 70 million of people.;71429;50000;H2020-SMEINST-1-2014;SME-1;REGULAXIS;FR;;; 196660;666610;VSP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Volumental - The Cloud-Delivered 3D Scanning Service Supporting A Future Of Mass Customization;1/04/2015;31/03/2017;;"Volumental is currently building, and delivering, leading software technology that enables the 3D scanning of objects, (e.g. bodies), using both current and emerging camera technologies. The resulting accurate scans can be readily used by mainstream 3D software systems & packages.

Volumental is currently focusing on the mass customization market, even though Volumental technology itself is broadly applicable. We sell software solutions B2B to e.g. footwear brands that can use 3D body data to customize e.g. shoes to the multibillion footwear market. We have a number of partners and pilot customers in this field already, among them US footwear brands and the worlds largest hardware manufacturers in our field.

Enabling technology development of mass customization in Europe offers the opportunity to move production products that touch the human body back to European markets as well as building technology leadership within fields such as 3D scanning and 3D printing.

The key differentiator for Volumental is that our proprietary software algorithms can produce high-accuracy 3D models using inexpensive hardware. Further on we excel in ease of use, having a cloud service and have a sustainable competitive advantage in the technology leadership our team has shown and continue to show.

For the Horizon 2020 project Volumentals high-level goal is to turn our technology and prototypes into fully functional products in their final end-user configuration. This translates to taking the products to TLR 8. This will require significant R&D to achieve mainly focused at improving robustness, free-hand accuracy, mobile phone scanning and API development. This R&D will result in additional inventions, so the project also aims to protect current and resulting inventions by analysing the current patent situation and filing relevant patents. The R&D in this project will follow an agile methodology and will be tightly linked to customer needs and envisioned products.";2087000;1460900;H2020-SMEINST-2-2014;SME-2;VOLUMENTAL AB;SE;;; 196609;641388;PETRA;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;PETRA - Photonic Environment moniToring Risk Assessment;1/02/2015;31/07/2016;;"The goal of PETRA (Photonic Environment moniToring & Risk Assessment) is the design and the IPR transfer of a radically new precommercial photonics based prototype for noninvasive continuous remote monitoring system for geo-technical risk assessment. PETRA will step from the ERC-funded project PHODIR that successfully carried out the realization and the field trial of the first photonic based radar prototype, and from the contacts that were made between CNIT and industrial partners during the PoC PREPaRE, that focused on the preindustrial design and IPR selling of an optics based radar for integrated traffic control in airports. The specific application on which PETRA will focus is the high precision real time analysis and mapping of potential risk areas for health protection, disaster prevention and for new civil engineering buildings (as bridges or power plants) where the advances of photonics will be of practical interest in a short-medium term, and it will: i) study the technical requirements and the current limitations of earth monitoring systems, to define the technical specifications for a commercial photonics based integrated radar system; ii) accordingly modify the radar structure and the data processing tools defined during the PHODIR project, allowing a short/medium-term industrial realization and commercialization with an attractive cost/performance ratio; iii) boost the IP transfer of each single subsystem preindustrial design to companies either through already filed patent selling or by encouraging companies to patent the presented design.";150000;150000;ERC-2014-PoC;ERC-POC;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;IT;;; 196622;644167;INPACT;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.;1/02/2015;31/01/2019;;"INPACT aims at the pre-clinical development of innovative drugs and drug formulations against selected cancers (eg prostate cancer) and pathogenic bacteria (eg S. aureus). The INPACT consortium allies the expertise of both academic and industrial R&D partners that contribute with their own unique technologies to achieve new drugs that are only possible to develop in an integrative effort. Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides (eg from Dengue virus) and ultra-resistant cyclic peptides that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs technologies. The judicious exchange of knowledge among partners will lead to new resistant peptides for trans-barrier delivery of drugs (eg cyclic peptide-drug chimeras) and bacterial killing (both planktonic and biofilms). INPACT includes four leading academic partners (from Portugal, Spain, Australia, and Brazil) and three consolidated biotech SMEs (one from Portugal and two Spain).
In addition to the R&D project itself, INPACT involves at the highest possible level a top business school in Europe (IESE, Barcelona, Spain), a consolidated media partner specialised in science communication (Ciencia Hoje, Rio de Janeiro, Brazil) and experts in international science funding from one of the top US universities (University of Stanford). The consortium will be the perfect environment for young researchers to acquire knowledge and skills in science, technology, entrepreneurship, business, and communication so they can pro-actively tailor their career path in a life-long learning perspective. This is a contribution towards the advancement of Europe through the use of research and education for societal development and economic growth.";1390500;850500;H2020-MSCA-RISE-2014;MSCA-RISE;INSTITUTO DE MEDICINA MOLECULAR;PT;"CENTRO ATLANTICO DEL MEDICAMENTO, SA;Universitat Pompeu Fabra;TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA;UNIVERSIDAD DE NAVARRA;PROTEODESIGN SL";"ES;PT"; 196643;657998;ENTRUST;SIGNED;H2020-EU.3.3.6.;LCE-20-2014;H2020;Energy System Transition Through Stakeholder Activation, Education and Skills Development;1/05/2015;30/04/2018;;"ENTRUST provides mapping of Europes energy system (key actors & their intersections, technologies, markets, policies, innovations) and an in-depth understanding of how human behaviour around energy is shaped by both technological systems and socio-demographic factors (esp. gender, age and socio-economic status). New understandings of energy-related practices and an intersectional approach to the socio-demographic factors in energy use will be deployed to enhance stakeholder engagement in Europes energy transition.
The role of gender will be illuminated by intersectional analyses of energy-related behaviour & attitudes towards energy technologies, which will assess how multiple identities and social positions, combine to shape practices. These analyses will be integrated within a transitions management framework which takes account of the complex meshing of human values and identities with technological systems. The third key paradigm informing the research is the concept of energy citizenship, with a key goal of ENTRUST being to enable individuals overcome barriers of gender, age and socio-economic status to become active participants in their own energy transitions.
Central to the project will be an in-depth engagement with 5 very different communities across the continent, who will be invited to be co-designers of their own energy transition. The consortium brings a diverse array of expertise to bear in assisting and reflexively monitoring these communities as they work to transform their energy behaviours, generating innovative transition pathways and business models capable of being replicated elsewhere in Europe.
Deliverables will include a policy tool-kit incorporating contemporary best practice in promoting energy transitions at a Europe-wide level; a suite of innovative transition pathways and community engagement tools designed to stimulate dialogue and break down barriers to behaviour change and the adoption new technologies at a community level.";3476394,59;3476394,58;H2020-LCE-2014-2;RIA;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;"ENERBYTE SMART ENERGY SOLUTIONS SL;LGI CONSULTING;INTEGRATED ENVIRONMENTAL SOLUTIONS LIMITED;REDINN SRL;STAMTECH SRL;Liverpool John Moores University";"ES;FR;UK;IT"; 196702;673824;ELECTHANE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Microbiological conversion of renewable electricity and CO2 to a natural gas quality bio-fuel;1/06/2015;31/05/2016;;"OWS wants to commercialize a biological process that converts CO2 and H2 (after electrolysis of renewable electricity) to CH4 (main component in natural gas). Lab and pilot tests have been and are being conducted and show promising results. A next step in the development is creating a sound business model for further commercialization, and the construction of a first plant at full-scale for further optimization and demonstration purposes to potential clients.

As renewable energy sources are gaining more ground in the electricity mix in Europe, imbalance problems on the electricity grid will increase in frequency. The proposed concept offers a solution to this imbalance problem by converting excess electricity via hydrolysis to H2 and using (waste) CO2 to CH4 that can be injected into the gas grid. The advantage of the proposed system is the small scale (< 10 MWe), so the conversion can be done near the production sites.

When there is an excess of renewable electricity, fees are paid to the operators of renewable electricity for not producing, thus avoiding grid imbalance. Although this approach is understandable from a balancing perspective, it is contradictory to a sustainable approach and in conflict with the existing renewable energy targets. Therefore, producers of renewable electricity are a first important target group for our technology.

CO2-intensive industries are a second important target group. By recycling their waste CO2, they become more sustainable, and it can generate extra revenues from buffering activities.

During the feasibility study, OWS wants to elaborate a sound business plan for further development of the technology. It should result in a clear vision on technical, economic and legal issues. The final goal is to build a first full-scale demonstration plant in phase 2, which can serve as a test facility for further optimization (technical/biological), but also as a demonstration plant for potential customers.";71429;50000;H2020-SMEINST-1-2014;SME-1;ORGANIC WASTE SYSTEMS NV;BE;;; 196699;673453;HybridFarm;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014;H2020;Eco-innovative housing solution for efficient production of slaughterpigs with limited environmental impact.;1/08/2015;31/07/2017;;"Pig meat is the preferred meat in Europe but its production has a dramatic environmental burden both in the local neighbour populations and in overall air pollution impact. Pig farming is at the center of clear conflict of interests, as there is a constant market drive to increase production efficiency, while society demands for an environmentally cleaner and more animal-friendly pig farming industry.
Agrifarm has developed a novel structural design for an eco-innovative barn for slaughterpigs the Intellifarm housing solution which makes use of its patented, prize-winning hybrid ventilation system and air cleaning technology to simultaneously reduce the need of mechanical ventilation and improve the capture of air polluting agents within the barn. The obtained results show massive energy savings compared with traditional ventilation systems, as well as a significant reduction of pollution emissions. Furthermore, it strongly contributes to an improved indoor quality, which translates into a healthier, quieter and more comfortable environment for the animals and staff inside the barn.
The remaining step towards commercial exploitation of the Intellifarm is its full scale demonstration and certification. This is directly addressed in the HybridFarm project, where the most important outcome is the construction of two Intellifarms at two different end-user sites in geographical key points to enter the market.
Intellifarm has the potential to decrease pig farming energy costs by 60%, while contributing to up to 50% gains in production profitability. At the same time, overall society burden of pig farming will be significantly reduced, thanks to the 71% global reduction on the emissions of ammonia and 37% reduction of odour, compared with a traditional barn. Moreover, this project opens an auspicious prospect for Agrifarm, which can lead the transition towards more resource-efficient pig farming, in a competitive market worth at 2.9 billion per year.";2046250;1432375;H2020-SMEINST-2-2014;SME-2;AGRIFARM INNOVATION APS;DK;;; 196610;641538;ConnectinGEO;SIGNED;H2020-EU.3.5.5.;SC5-18a-2014;H2020;Coordinating an Observation Network of Networks EnCompassing saTellite and IN-situ to fill the Gaps in European Observations;1/02/2015;31/01/2017;;"ConnectinGEOs primary goal is to link existing coordinated Earth Observation networks with science and technology (S&T) communities, the industry sector and the GEOSS and Copernicus stakeholders. The aim is to facilitate a broader and more accessible knowledge base to support the needs of the GEO Societal Benefit Areas (SBAs) and their users. A broad range of subjects from climate, natural resources and raw materials, to the emerging UN Sustainable Development Goals (SDGs) will be addressed. A tangible outcome of the project will be a prioritized list of critical gaps within the European Union in observations and the models that translate observations into practice-relevant knowledge. The prioritized list will include the research activities required to address these gaps. Ultimately, this will increase coherency of European observation networks, increase the use of Earth observations for assessments and forecasts and inform the planning for future observation systems through a sustainable approach that will survive beyond the end of this project.

ConnectinGEO has 4 major objectives:
a) Enable a European Network of Earth Observation Networks (ENEON) including space-based, airborne and in-situ observations networks.
b) Provide a methodology to convert the knowledge needs into a coherent observation and measurement compendium for ENEON strategy and development.
c) Apply the ConnectinGEO methodology to identify and assess the priority of gaps.
d) Open the results of the project and exploit them beyond the project end.";999995,94;999995,94;H2020-SC5-2014-one-stage;CSA;CENTRO DE INVESTIGACION ECOLOGICA YAPLICACIONES FORESTALES;ES;"INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE;INSTITUT ROYAL D'AERONOMIE SPATIALE DE BELGIQUE;SCIENCE AND TECHNOLOGY BV;THE UNIVERSITY OF EXETER;EUROPEAN ASSOCIATION OF REMOTE SENSING COMPANIES;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;52North Initiative for Geospatial Open Source Software GmbH;ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS;INSTITUT MINES-TELECOM;CONSIGLIO NAZIONALE DELLE RICERCHE;NORSK INSTITUTT FOR LUFTFORSKNING;TIWAH UG (HAFTUNGSBESCHRAENKT);IEEE FRANCE SECTION;FONDAZIONE CENTRO EURO-MEDITERRANEO SUI CAMBIAMENTI CLIMATICI";"AT;BE;NL;UK;ES;DE;FR;IT;NO"; 196623;644271;AEROARMS;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;AErial RObotic system integrating multiple ARMS and advanced manipulation capabilities for inspection and maintenance;1/06/2015;31/05/2019;;"AEROARMS proposes the development of the first aerial robotic system with multiple arms and advanced manipulation capabilities to be applied in industrial inspection and maintenance (I&M). The objectives are:

1. R&D on aerial manipulation to perform I&M. This includes: 1.1 Based on previous partner results, developing systems which are able to grab and dock with one or more arms and perform dexterous accurate manipulation with another arm. Also develop helicopter-based aerial manipulators, with greater payload and flight endurance, and with a dexterous arm to provide advanced manipulation capabilities by means of force interactions and hand-eye coordination using a movable camera with another light arm; 1.2 New methods and technologies for platforms which can fly and manipulate with the coordinated motion of the arms addressing constrained scenarios in which it is dangerous to use the helicopter and where it is not possible to grab to perform I&M operation.

2. Validation of 1.1 in two applications: 1) Installation and maintenance of permanent NDT sensors on remote components; 2) Deploy and maintain a mobile robotic system permanently installed on a remote structure.

To achieve the above objectives AEROARMS will develop the first aerial telemanipulation system with advanced haptic capabilities able to exert significant forces with an industrial robotic arm, as well as autonomous control, perception and planning capabilities. Special attention will be paid to the design and system development in order to receive future certification taking into account ATEX and RPAS regulations.

AEROARMS is strongly related to ICT 232014: Robotics enabling the emergence of aerial robots, with manipulation capabilities to operate in industrial I&M, which will be validated in in oil and gas plants to reach TRL5.

The consortium combines excellent capabilities in aerial robotics with leadership in aerial manipulation and key partners for the successful application of I&M.";5719602,5;4722852;H2020-ICT-2014-1;RIA;UNIVERSIDAD DE SEVILLA;ES;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;ELEKTRA UAS GMBH;GE INSPECTION ROBOTICS AG;FUNDACION ANDALUZA PARA EL DESARROLLO AEROESPACIAL;C.R.E.A.T.E. CONSORZIO DI RICERCA PER L'ENERGIA L AUTOMAZIONE E LE TECNOLOGIE DELL'ELETTROMAGNETISMO;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;TUV NORD SYSTEMS GMBH & CO KG;UNIVERSITAT POLITECNICA DE CATALUNYA;SENSIMA INSPECTION SARL";"DE;CH;ES;IT;FR"; 196573;674758;CiWater;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Feasibility study for water leakage detector CiWater;1/05/2015;31/10/2015;;"A water distribution network is an important part of the infrastructure. In every water pipe system around the world more than 20% of the produced water is lost before it reaches the consumer, corresponding to a production cost of more than 20 M every day. It is a challenge to find small leakages before they became major and causing an emergency.

Cinside has the ambition to grow and internationalise. With this project we will get a new innovative and unique product that strengthens the company's competitiveness in the environmental area and increasing the future revenue opportunities. The main selling points are to save money, energy and valuable nature resources. The system has a worldwide market with the potential of 100000's of users.

The aim is to develop a handheld radar based system to pinpoint the leakages in a more accurate and effective way than available methods like correlator and electro-acoustic techniques.

The idea is to use the Cinside proprietary hardware and Doppler signal processing previously developed to find humans behind walls and in rubble by detecting very small physical movements.

In a previous project we have built a demonstrator showing that we can detect water leakages in certain environments. To get a fully working easy-to-use product we need to gain more experience from different leakage conditions.

In phase 1 we will investigate the properties of different leakage conditions, and from that make a project plan for development in phase 2. We will also do a market survey to be able to setup a realistic business plan. We will search for certain experts and end-users around Europe, in addition to the end-user group already formed in Sweden, to find partners willing to participate in phase 2.

In phase 2 we will develop the product from TRL6 to TRL9. The participating end-users will contribute with experience, trial areas, real leakages and verification. To complete this project we will need external financing.";71429;50000;H2020-SMEINST-1-2014;SME-1;CINSIDE AB;SE;;; 196685;659961;PIGRISK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigation into emerging, evolving or novel viruses of swine in respiratory, reproductive and enteric pathologies: horizon scanning for risks to swine health and food security;4/04/2016;3/04/2018;;"Emerging viruses pose a significant threat to animal health and welfare, food security and rural prosperity. When porcine circovirus 2 (PCV2) emerged in the late 1990s after circulating in pig populations for at least several decades before. The associated disease post-weaning multisystemic wasting syndrome (PMWS) is estimated to have cost the EU over 600 M euros per year at its peak. The emergence of a highly pathogenic strain of porcine epidemic diarrhoea virus (PEDV) in the US and Asia has resulted in the death of millions of pigs and the economic costs are still being counted. Here we propose a research project that will increase our understanding of emerging, evolving or novel viruses in swine in order to allow assessment of and improved response to, current and future socioeconomic threats to the European agri-food industry. This project aims to: (1) Develop, enhance and apply a range of classic and beyond the state-of-the-art diagnostic methods for the detection of emerging, evolving or novel viruses in swine in a world-class institute with a long history of successful virology research including identification and commercialisation of PCV2; (2) To statistically establish disease association of detected viruses with these considering viral load aspects of infection; (3) To statistically establish disease association of combinations of virus in co-infection scenarios; (4) To develop next generation sequencing (NGS) methods to allow characterisation of the entire viral flora of pigs with particular disease states; (5) To parallel these research activities with a comprehensive, multi-disciplinary training programme including laboratory and non-laboratory scientific and IT skills as well as training in a range of professional skills to provide a competitive advantage in the job market for the next stage of their career. This will allow improved horizon scanning for as well as rapid response to emerging threats to the swine industry.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGRIFOOD AND BIOSCIENCES INSTITUTE;UK;;; 196594;673315;DWAVE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Designing waves for the people;1/06/2015;30/11/2015;;The objective of this project is the creation of Wavegardens all around the world. A Wavegarden is a place where surfers can practice surf: a lagoon in which a mechatronic device creates waves that could fulfil surfers expectations. According to the report Blue Growth Scenarios and drivers for Sustainable Growth from the Oceans, Seas and Coasts, Third Interim Report, March 2012 an important niche in coastline tourism is represented by nautical sports. For example, 10 million people in the world travel each year to wind and wave surfing destinations and the trend is growing, and 500 thousand more people every year practice this sport. Surfing is ranked in the top 20 most popular and fastest growing sports in all countries, cultures and demographics. The surfing industry, with an economic impact in the range of US$100 billion, is estimated to continue its growth in the years to come. The stoke, or feeling, of surfing, which has been limited to the lucky few who live near quality surfing waves, is now accessible to everyone thanks to Wavegarden.;71429;50000;H2020-SMEINST-1-2014;SME-1;INSTANT SPORT SL;ES;;; 196684;659279;STEM ZAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Optogenetics based discovery of new pathways towards stem-cell mediated myelin repair;6/04/2016;5/04/2018;;Neurological disorders, such as multiple sclerosis (MS), that involves degeneration of the myelin sheath exact a social and economic toll on the EU estimated at 14.6 billion Euros per year. Consequently therapies capable of regenerating damaged myelin are an important clinical goal. The aim of this fellowship is to develop new strategies for the replacement of myelin through the use of embryonic stem (ES) cells. We propose to achieve this aim by identifying novel signalling molecules capable of enhancing the generation of myelin-forming oligodendrocytes from ES cells. Membrane depolarisation enhances myelination during postnatal development, and can promote the differentiation of ES-OL cells. However, the impact of depolarisation on the generation of oligodendrocytes from ES cells (ES-OL) is unknown, as are the signalling molecules driving depolarisation-induced ES cell differentiation. Filling these gaps has the potential to deliver new methods for increasing the supply of pro-myelinating ES-OL capable of regenerating damaged myelin. This fellowship will unite supervisor Dr Fultons expertise in oligodendrocyte biology and optogenetics with Dr Otsus knowledge and skills in novel methods for the efficient production of ES-OL. In addition, partner organisations from the commercial and clinical sectors will add additional expertise that will enhance the projects research capacity, and ensure success in its goal of developing novel pathways towards myelin regeneration.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 196574;674923;EUCYS2015;SIGNED;H2020-EU.5.;SCIENCE WAF SOCIETY;H2020;EUROPEAN UNION CONTEST FOR YOUNG SCIENTISTS 2015 IN MILAN;1/01/2015;31/12/2015;;"'The present proposal is relevant to the organization of the 27th edition of EUCYS-European Union Contest for Young Scientists, to be held in Milan from September 17 to 22, 2015.
FAST, the Italian National Organizer - based in Milan - has worked to put together the national and local institutions, as well as private and public entities, to collaborate at this important event sharing the EU objectives to support the best young students in EU, associated and invited countries.
Moreover, considering the opportunity of EXPO 2015 due to be held at the same time, and thanks to the collaboration of the Steering Committee for the EXPO - EU Scientific programme, the contest will take advantage of a special initiative: the EU and associated countries will be encouraged to promote one extra project proposal linked to the themes of Expo 2015 'Feeding the Planet. Energy for Life'. In this way, the contest will be enriched with more contestants and projects.
This proposal is defined as the set of all the actions needed to prepare and organize the 2015 event with a maximum impact, in terms of: support to the National organizers, contestants, Jury, and all other participants, before, during and after the Eucys week; organization of the overall programme; choice of hotel accomodation and venues; communication plan and press conferences. A strong dissemination plan will be studied in order to meet public interest (especially teachers, students and scientists), as well as to attract media attention.
Therefore, all the necessary elements and items to assess the feasibility of the project, including the draft programme, the objectives, impacts and financial provisions are included in this activity prepared by FAST.
The final aim of EUCYS 2015 is the promotion of science and technology among young people, according to the scopes of the Science with and for Society Programme within Horizon 2020.'";1134437,5;800000;H2020-Adhoc-2014-20;CSA;FAST - FEDERAZIONE DELLE ASSOCIAZIONI SCIENTIFICHE E TECNICHE;IT;;; 196698;673447;MD-SD-OCT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014;H2020;An innovative double technologies medical device for corneal diseases.;1/06/2015;31/05/2017;;"It has been observed that eye related disease such Keratoconus, glaucoma and cataract are recently increased, especially in older adult, which are commonly more prone to this kind of pathology, with a significant rise also in young adults subject, due to nowadays lifestyle. The first main objective of CSO business project is to introduce into the market the innovative MD-SD-OCT, a new ophthalmology instrument, which is able to detect, with a single tool, a range of optical pathologies wider than the state of the art technologies are capable to support, with higher performances and significant reduction of manufacturing cost. This target will be reached through the integration of traditional topography approach (Placido's disk) and innovative patented Spectral Domain Optical Coherence Tomography (ref. WO 2014/155286 A1), into a single, compact and flexible diagnosis device, real breakthrough for the market at the state of art.
As a results of the technology innovation proposed and due to the usage of a less expensive technology invented by CSO (new SD-OCT management system, covered by international patent), the overall cost of the device is significantly lower than the existing applicable technology (about 45% less). This aspect will be the most disruptive and distinguishing element of the entire business project and will determine a huge increase of the company competitiveness.
As a result of intensive market need research, performed by the company in the last two years, and thanks to its expertise in R&D for design and manufacturing of innovative ophthalmology diagnosis devices, CSO, with higher performance , significantly lower cost and new double technology MD-SD-OCT will be able to strongly improve its competitiveness in the market of ophthalmology diagnosis devices.";1965867,5;1965867,5;H2020-SMEINST-2-2014;SME-2;COSTRUZIONI STRUMENTI OFTALMICI C.S.O. SRL;IT;;; 196580;641156;KidsSurgicalPlan;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;KidsSurgicalPlan: An Internet enterprise for sketch-based cardiovascular pre-surgical planning;1/06/2015;30/11/2016;;Approximately 1 in 100 children are born with a clinically significant congenital heart defect representing 47,000 children each year in the EU. Survival of the newborn requires series of complex open-heart surgeries where optimal hemodynamic performance is essential for improved post-operative quality of life. This work proposes a new computationally-enhanced interactive system for patient-specific pre-surgical design and optimization of pediatric cardiovascular surgeries. With the proposed system, clinicians will be able to rapidly implement a contemplated intervention on a patient-specific 3D computer model without execution. A novel interface will allow clinicians to communicate their surgical intentions directly on the computer model analogous to the way they would communicate their intentions to other clinicians or bioengineers. Basic cardiovascular research on embryonic biomechanics that is being investigated in the parent ERC project will provide the essential foundation of the proposed predictive capability. This interactive framework will be deployed to the web for worldwide impact. Based on market analysis our proposed business model becomes profitable in a short time. PoC project will provide necessary resources for developing the prototype patient-specific surgical-planning framework, clarification of regulatory pathways and follow-up pre-clinical research design.;150000;150000;ERC-2014-PoC;ERC-POC;KOC UNIVERSITY;TR;;; 196588;656067;NOVENA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploiting an unusual polyketide chain release mechanism for production of novel enacyloxin antibiotic analogues;1/06/2015;31/05/2017;;Enacyloxin IIa is a polyketide antibiotic with activity against Gram-positive and Gram-negative bacteria that targets ribosomal elongation factor Tu. It has recently been identified as metabolite of Burkholderia ambifaria AMMD and shown to have clinically-relevant activity against Acinetobacter baumannii, a problematic pan-resistant Gram-negative pathogen. Despite its promising biological activity, enacyloxin IIa has not been used in the clinic, presumably due to stability issues. Preliminary experiments have provided evidence for an unusual mechanism of modular polyketide synthase chain release in enacyloxin biosynthesis, involving intermolecular condensation of an acyl carrier protein (ACP)-bound thioester with the C-3 hydroxyl group of (1R, 3R, 4S)-3,4-dihydroxycyclohexane carboxylic acid (DHCCA). The resulting intermediate undergoes epimerisation at C-1 of the DHCCA moiety. This project aims to explore the ability of the chain release enzyme to catalyse the acetylation of a variety of DHCCA analogues with an acetyl-ACP analogue of the polyketide thioester intermediate. It also aims to identify the enzyme responsible for epimerising C-1 of the DHCCA moiety. DHCCA biosynthetic genes will be deleted in B. ambifaria and enacyloxin analogues, with a stable amide group in place of the labile ester group and other modifications to the DHCCA-derived moiety, will be produced via a mutasynthesis strategy.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 196586;655710;CONRICONF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Contentious Rights: A Comparative Study of International Human Rights Norms and their Effects on Domestic Social Conflict;17/01/2016;16/01/2019;;"Contentious Rights: A Comparative Study of International Human Rights Norms and their Effects on Domestic Social Conflict

Over the last 60 years, a broad set of international norms gained importance as instruments to regulate a globalising world. Enshrined in human rights conventions, these norms contribute to strengthen a platform for social mobilization and voice. The introduction of human rights standards at the domestic level, however, has also been responsible for the generation of new tensions on the interpretation and application of these norms. Yet, this type of conflict and polarization among social and political actors remain widely unexplored. This project will examine how human rights act in practice in the post-ratification phase using a multidisciplinary perspective and an empirical comparative approach. More precisely, it addresses the task of identifying the conditions under which international norms generate consensus and cooperation or fragmentation and conflict between domestic social and political actors and the consequences in terms of human rights practices. The candidate fellow Dr. Lorenza Fontana will focus on a comparative analysis of two conventions (International Labor Organizations Conventions 182 on Child Labor and 189 on Domestic Workers) in two countries (Bolivia and Philippines) and lead an interdisciplinary collaboration between Prof. Jean Grugel (University of Sheffield, SIID), and Prof. Beth Simmons (Harvard University, WCFIA). This project will greatly increase our understanding of the effects of human rights norms on domestic societies and provide policy relevant results.";269857,8;269857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE OPEN UNIVERSITY;UK;;; 196582;649323;3D Reloaded;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;3D Reloaded: Novel Algorithms for 3D Shape Inference and Analysis;1/09/2015;31/08/2020;;"Despite their amazing success, we believe that computer vision algorithms have only scratched the surface of what can be done in terms of modeling and understanding our world from images. We believe that novel image analysis techniques will be a major enabler and driving force behind next-generation technologies, enhancing everyday life and opening up radically new possibilities. And we believe that the key to achieving this is to develop algorithms for reconstructing and analyzing the 3D structure of our world.

In this project, we will focus on three lines of research:

A) We will develop algorithms for 3D reconstruction from standard color cameras and from RGB-D cameras. In particular, we will promote real-time-capable direct and dense methods. In contrast to the classical two-stage approach of sparse feature-point based motion estimation and subsequent dense reconstruction, these methods optimally exploit all color information to jointly estimate dense geometry and camera motion.

B) We will develop algorithms for 3D shape analysis, including rigid and non-rigid matching, decomposition and interpretation of 3D shapes. We will focus on algorithms which are optimal or near-optimal. One of the major computational challenges lies in generalizing existing 2D shape analysis techniques to shapes in 3D and 4D (temporal evolutions of 3D shape).

C) We will develop shape priors for 3D reconstruction. These can be learned from sample shapes or acquired during the reconstruction process. For example, when reconstructing a larger office algorithms may exploit the geometric self-similarity of the scene, storing a model of a chair and its multiple instances only once rather than multiple times.

Advancing the state of the art in geometric reconstruction and geometric analysis will have a profound impact well beyond computer vision. We strongly believe that we have the necessary competence to pursue this project. Preliminary results have been well received by the community.";2000000;2000000;ERC-2014-CoG;ERC-COG;TECHNISCHE UNIVERSITAET MUENCHEN;DE;;; 196558;674266;HELMO;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Cardiovascular Diseases Diagnoses by means of Smart Remote Monitoring System based on known Heart Activity Biomarkers;1/05/2015;31/08/2015;;"Cardiovascular Diseases are the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to >23.6 million by 2030. In Europe, it accounts for over 4 million deaths each year which means nearly half 47% of all deaths. Overall CVD is estimated to cost the EU economy almost 196 billion a year. It is clear that there is an economic demand to implement cost effective measures to early diagnoses of CVD and detection of highs risks to suffer a fatal event. The WHO has prioritized these interventions as: early identification of people at high risk in primary care and monitoring of survivors of a heart attack or stroke which are at high risk of recurrences or dying from them. Indeed, spurred by the hefty bill and lack of resources, Hospitals are continuously looking for new solutions to allow them to discharged chronical inpatients who can be remotely monitoring improving its quality of life and providing tailored treatment.
The project HELMO aims at developing and clinically validating a no-invasive remote monitoring medical device for the early diagnoses of cardio vascular diseases (CVD) and to provide assistance before fatal consequences, even death. The product will be launched to the market as an innovative system able to monitor remotely 10 vital parameters which are well known biomarkers of CVD diseases: ECG 12 leads ECG -, heart and breath rates, blood pressure, movement, oxygen saturation, body temperature, sweat, calories, location. This device, designed by all population including special needs group, will provide alerts both patients and clinicians at critical moments which can lead to loss of consciousness and death.
As a result, the number of hospitalization caused by CVD and eventually the deaths will experiment a significant reduction. HELMO is a non-invasive medical device based on the monitoring of CVD biomarkers which commercialization will mean 14.4 M revenues for XEOS by 2022.";71429;50000;H2020-SMEINST-1-2014;SME-1;XEOS.IT SRL;IT;;; 196608;641003;C-ENERGY 2020;SIGNED;H2020-EU.3.3.;LCE-22-2014;H2020;Connecting Energy National Contact Points in a pro-active network under Societal Challenge 3 'Secure, clean and efficient energy' in Horizon 2020;1/12/2014;30/11/2018;;"C-ENERGY 2020 is a 48 months Coordination and Support Action having the specific objectives to Ensuring high quality Energy NCP services for Horizon 2020 and related programmes applicants; Lowering entry barriers for Energy NCPs approaching EU Framework Programmes for R&I for the first time; Consolidating the network of Energy NCPs. C-ENERGY 2020 project will take into consideration the significant changes that Horizon 2020 has brought about the Energy NCP mandate. With its brand new approach to R&I Horizon 2020 demands Energy NCPs: a) to address their services to a wider target, b) to have specific multidisciplinary competences. C-ENERGY 2020, whose consortium is composed by experienced and less experienced Energy NCPs from 18 countries, will tackle these challenges building up the NCP capacity by organising benchmarking activities, at least 8 training sessions and 12 twinning schemes. The dialogue with energy participants will benefit of at least 2 enhanced cross-border brokerage events and 9 training sessions for stakeholders. The project will also take special care of outreaching activities by extending the collaboration with other NCP thematic networks, cooperating with EEN, working on partner search and cooperating on international relevant activities. Finally, communication within and outside the Energy NCP network and the dissemination of results will be ensured through the website, the development of promotion/information materials, the participation at major events and PR activities and an e-mail alert service/newsletter. Throughout the project special attention will be paid to the diversity of stakeholders in the energy sector, the gender dimension, as well as to establish links with other EU relevant initiatives, programmes and policies.";1500000;1500000;H2020-LCE-2014-4;CSA;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;IT;"GIS-TRANSFERCENTER FOUNDATION;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;SIHTASUTUS EESTI TEADUSAGENTUUR;AGENCE DE L'ENVIRONNEMENT ET DE LA MAITRISE DE L'ENERGIE;FORSCHUNGSZENTRUM JULICH GMBH;IDRYMA PROOTHISIS EREVNAS;AGENCE BRUXELLOISE POUR L'ENTREPRISE;ENTERPRISE IRELAND;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;The Technology Strategy Board;NORGES FORSKNINGSRAD;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;ETHNIKO IDRYMA EREVNON;LUXINNOVATION GIE;MATIMOP - THE ISRAELI CENTER FOR R&D;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"BG;AT;EE;FR;DE;CY;BE;IE;PL;UK;NO;HR;ES;EL;LU;IL;PT"; 196593;672921;FILMCO;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Greenhouse film covers with tailor-made properties for enhanced performance;1/05/2015;31/10/2015;;FILMCO by Elysee Irrigation Ltd. a Cyprus-based manufacturer and worldwide supplier of piping and irrigation systems for agricultural, domestic and public use - will bring to the market a high performance film cover for greenhouses based in nanomaterials technology, offering significant benefits to growers due to the use of advanced polymer nano-composites. FILMCO is a greenhouse film that has already probed to provide the growers with energy consumption savings by 24-28%, and increase their crop production by 20%. FILMCOs main innovation is the ability to regulate the Photosynthetically active radiation (PAR) for a given Infrared Radiation (IR), thus controlling the degree of rightness/darkness according to the location requirements. The novel film will have increased robustness, added to higher pesticide and UV and oxidation resistance. The film will create a controlled environment in the greenhouse while lowering energy demands, reducing costs and promoting a better use of resources and higher crop yield. The longer lifespan will also reduce plastic waste and decrease waste management expenses. Although nanotechnology has emerged in industrial applications over the last decades, there is no similar commercial product available in the growing greenhouse agriculture market that matches the benefits and competitive advantages of FILMCO. FILMCO, with TRL 6, is the outcome of a national research project in which Elysee already demonstrated these promising results benefits for growers, so it became a success history. Via FILMCO, Elysee estimates a new revenue stream valued at 13.7M over the first 5 years of commercialisation, and also will hire 10 new employees for the production line. The feasibility assessment will address both, business and technological aspects, aiming to obtain end-user feedback and market knowledge that will be the basis for identifying the steps to take towards up-scaling the technology and for review the business plan.;71429;50000;H2020-SMEINST-1-2014;SME-1;ELYSEE IRRIGATION LTD;CY;;; 196653;663704;ISO-COLD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Integrated SOlution to enhance COLD chain and logistic tracking;1/02/2015;31/07/2015;;"Scenario
Transport & Logistic (T&L) sector has experienced a fast expansion in the last decade; the temperature controlled supply chain represents a high value added segment that is experiencing a continuous push for service quality. Regulators, all over the world, are constantly introducing more demanding recommendations (e.g.: the recent Good Distribution Practise - EU C343/01 2013 - for the pharmaceutical products). On the other hand, the high cost of monitoring tracking information and temperature data during transports, and the absence of structured ICT solutions to aggregate operative information efficiently, risk frustrating regulators effort.
Innovation
ERPlan developed a comprehensive ICT solution able to collect and aggregate information from T&L operations, including track & trace and temperature data that allow the users to have a complete and updated status of deliveries, an historical records depot for regulation compliance, and a platform to distribute data to its stakeholders. Moreover, the solution provide logistic floor and mobile systems equipped with state of art RFID technology to minimize impact of data acquisition procedures on workforce efficiency.
Target Market
Transport and logistic companies working with temperature controlled shipments (mainly Pharma & Food sectors) are all potential users of the solution as well as their stakeholders (Pharma / food producers, retailers, etc.) with a focus companies operating in last mile delivery scenario (mostly SMEs)
Phase I Objectives
- To define the investment and the effort that the company should undertake to penetrate efficiently the European market
- To validate the ability of the solution to bring economical return to the company into a defined period in order to evaluate sustainability of the business plan
- To quantify the impact of the solution on standard transport / logistic scenarios to create appropriate selling tools
- Produce a sustainable marketing strategy to enter the European market";71429;50000;H2020-SMEINST-1-2014;SME-1;ERPLAN SRL;IT;;; 196599;685436;EHW15;SIGNED;H2020-EU.3.1.;Health;H2020;High Level eHealth Conference 2015;19/03/2015;18/08/2015;;"Taking into account that, according to the priorities set by the Latvian Presidency of the Council of the European Union, it is intended to actualize the EUs digital single market, e-governance and citizens e-skills improvement, as well as the security of information in the digital environment and internet freedom issues. Latvian Presidency wishes to promote a new concept how we can increase patients participation in their own healthcare and emphasize the role that eHealth and mHealth have to play.

The High Level eHealth Conference collocated with the World of Health IT Conference & Exhibition (WoHIT) under the common title eHealth Week 2015 provides a unique platform to bring together all the involved parties necessary for successful implementation of e-health and m-health - policy makers, high level global decision makers from public and private healthcare sectors, ICT solution developers, hospital and IT managers, healthcare professionals and patient groups from NGOs.

The general aim to the High Level eHealth Conference is to emphasize the importance of the patient involvement as the key enabler for better MS health systems. The conference High Level eHealth Conference also will fortify the cooperation among European regions, give the positive push to e-health further development at the whole Baltic and Nordic region and strengthen collaboration among the MS in healthcare sector.
Relevance to the Work Programme - HOA 32014/2015: Presidency events - eHealth.";312398,5;300000;H2020-Adhoc-2014-20;CSA;NACIONALAIS VESELIBAS DIENESTS;LV;;; 196697;673373;Collect and Reflect;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Reducing energy consumption and carbon footprint by implementing Collect and Reflect(TM) blinds for solar energy collection and reflection (Collect and Reflect);1/02/2015;31/07/2015;;"Rising energy bills is a relevant topic for households in the European Union. The share of household income spent on energy bills is growing and is impacting not only low-income households. Many of existing solutions for lowering energy bills for households are expensive and are targeted at home owners. They include new passive buildings, better insulation of existing buildings and/or generation of locally renewable energy (e.g. geo-thermic, solar, wind).
Even though many already proven solutions exist that aim to increase energy efficiency and energy production in buildings via walls and roofs, windows are usually considered as a subject of energy loss and not taken into account for sustainable energy production. Could we optimize certain features of windows, such as blinds, and how should we do it? We believe that in the future, window blinds could add additional warmth in the winter and help to keep rooms cool in the summer; become a source of light; produce electricity; and when needed, block or let light in. By working on the Collect & Reflect project, Saul?s v?jo aruodai (SVA) is making first steps to realize this dream by inventing blinds that can heat and cool.
SVA, an SME from Lithuania, invents, patents, makes and supplies solar energy transformation products. Recently SVA has invented a break-through solution, Collect & Reflect(TM) thermal blinds, which can help save energy and thus reduce energy bills and decrease the carbon footprint of households. These blinds have innovative technology and special coating that make rooms warmer during the winter and colder in the summer. They help to decrease the need to heat and cool rooms, which results in lower energy bills and lower CO2 emissions. Collect & Reflect(TM) thermal blinds have huge potential to affect the window treatment market worldwide and transform traditional blinds into an active energy saving tool accessible for any household.";71429;50000;H2020-SMEINST-1-2014;SME-1;UAB SAULES VEJO ARUODAI;LT;;; 196598;674539;HardALU;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Fluidised Bed Heat Treatment Furnace for HPDC engine blocks and other transport components offering new opportunities for lightweight, cost competitiveness and energy saving;1/06/2015;31/05/2018;;"Advanced manufacturing technologies are needed in order to facilitate the production of high performance light weight aluminium components. HPDC is highly productive process but the conventional heat treatment technology cannot be applied due to the formation of blisters of entrapped gas. This project offers to the foundries and automotive companies industrial FB lines able to heat treat the key parts and thus it will lead the company growth for the next years from a high technology solution developer to an important stakeholder in automotive industry.
Since its foundation in 1989, HORMESA has specialized in the equipment, materials and turnkey solutions for non-ferrous foundries, mainly Aluminium and Copper alloys. Customer driven attitude and continuous technology development allow us to offer practical solutions for industrial processes. Specialization and globalization are two forces that strongly influence this entity with result of a consolidated 25% growth during the 2009-2012 period.
This project is natural next step as it is the next phase to develop the companys strategy:
- To enable heat treatment of High Pressure Die Cast HPDC parts (which are not heat treatable with conventional furnaces), thus increasing their tensile strength by a 100 % and making it possible to reduce their weight or replace heavier iron castings, particularly in the case of engine blocks.
- To reduce by 2% CO2 emission by increasing replacing iron (a reduction of 28 kg is expected from replacing a iron engine of block of average 55 kg by an aluminium one)
- To generate a new niche market of heat treatment lines for HPDC parts: 1 industrial line for FB heat treatment of HPDC engine blocks in the first year after finishing the project, and 3 lines in the second year (engine blocks or others).
- Additional 30 % of reduction of CO2 emission associated to the reduction of gas consumption when the alternative FB T6/T7 heat treatment is applied";909250;636475;H2020-SMEINST-2-2014;SME-2;HORNOS Y METALES SA;ES;;; 196683;659147;PrecisionTools4LHC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High precision predictions and tools for LHC Physics;1/10/2015;30/09/2017;;"The CERN Large Hadron Collider (LHC) has opened a new exciting era in fundamental Particle Physics, by reaching energies never probed before in a collider experiment. The data collected in 2010-2013 already led to an historical achievement, the discovery a new-particle with properties very close to those predicted for the Standard Model Higgs boson. The pivotal role played by this particle calls for an extremely accurate study of its properties. Together with the search for direct signals of New Physics at the ~10 TeV scale, this will be the major topic of research over the next 20 years, throughout the whole duration of the LHC experiment.

Especially in absence of striking signature pointing to Physics Beyond the SM (BSM), the success of this long-term programme relies on the capability of extracting precise informations from the measured data.
In addition to extraordinarily sophisticated experimental equipment, accurate theoretical predictions for the sought-after signals and their known backgrounds are required.

The goal of this research proposal is to push the precision of Monte Carlo programs needed to interpret LHC measurements to an unprecedented level. This will be achieved combining several novel techniques developed in the Monte Carlo community and results obtained in perturbative QCD. The realization of the specific objectives detailed in the proposal will allow to model more reliably signal and background processes relevant to perform a variety of overriding precision studies.
This will permit a more solid interpretation of future measurements and, in a longer timescale, will also be instrumental in continuing to improve the accuracy of simulation tools.";175419,6;175419,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;;; 196584;647168;Myelination;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Cell biology of myelin wrapping, plasticity and turnover;1/08/2015;31/07/2020;;The myelin sheath is a plasma membrane extension that is laid down in regular spaced segments along axons of the nervous system. In the central nervous system it is formed by oligodendrocytes that spirally wrap their plasma membrane around axons to generate a highly abundant, tightly packed stack of membranes with unique structural properties. Previously, myelin has been regarded as an inert and purely insulating membrane, but it now appears that myelin is metabolically active, providing metabolic support to the underlying axon and participating in information processing by modulating velocity and synchronicity of nerve impulses in neuronal networks. In addition, myelination is not limited to the period of early post-natal development, but continuous into adulthood where it appears to be regulated by neuronal stimuli. This paradigm shift should be fuelled by new knowledge about myelin biology. Here, we plan to fill this gap by addressing the molecular basis of myelin growth, plasticity and remodelling. We will determine the factors that determine whether and to what extent an axon will be myelinated or not, the forces that drive myelin around the axon, the structural basis of myelin plasticity and the mechanisms of myelin turnover in the adult. We will test the hypothesis that microglia actively participate in myelin turnover by taking up myelin fragments that pinch off from the myelin sheath. To realize these aims we plan to pursue an integrative and multidisciplinary approach by bringing together genetics, biochemistry, proteomics and imaging in various model systems. The innovation arises from the combination of high-resolution imaging with molecular approaches in different cell types to obtain a unifying mechanistic understanding of myelin formation, maintenance and degradation. If successful, the project would not only explain how myelin is generated during brain development, but also give insight into how myelin plasticity could fine-tune neuronal networks.;1872500;1872500;ERC-2014-CoG;ERC-COG;TECHNISCHE UNIVERSITAET MUENCHEN;DE;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE; 196560;674319;Mustang-Pro;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;A Multi-species tracking analyser for natural gas process refinement and optimisation;1/05/2015;31/10/2015;;"Natural gas is the worlds fastest growing fossil fuel with global consumption expected to increase by 70%, from 4 tn m3 in 2014 to 7 tn by 2040. Raw natural gas varies in composition and also contains undesirable impurities and contaminants, including water, CO2, nitrogen and hydrogen sulphide (H2S). Unconventional sources such as shale gas have an even greater variance. Despite this, the composition of gas delivered to transmission pipelines has to be tightly controlled by the gas producers to meet stringent quality standards and specifications.

Natural gas therefore has to be processed to remove these contaminants. With high financial penalties or the threat of closure for gas producers not meeting high quality standards, and because producers do not currently have sufficiently accurate data on the gas composition at any one time, most natural gas is highly over processed. This is time consuming, energy intensive and leads to high CO2 emissions. It is also ultimately expensive, (a cost of 91 billion p.a globally).
The industry has an urgent and growing requirement for a new gas analyser that can accurately and rapidly measure the composition and contaminant levels of the gas stream so that the gas processing stage can be optimised.

The aim of this innovation project is to bring to technology maturity and market readiness a disruptive, cost effective, multi-species natural gas analyser to improve the energy efficiency of natural gas processing facilities by up to 20%. Our technology is at proof of concept stage (TRL6) and is based upon a novel, method of thermal laser frequency control. Mustang PRO is the worlds first multi species, cost effective TDLAS analyser. The Phase 1 project will deliver vital market and end user data to elaborate our business plan for Phase 2. We aim to save the EU industry 1.3bn p.a. in gas processing costs whilst generating revenues of 51 million, 7 years post project, creating 54 jobs and a profit (EBITDA) of 20.9 m.";71429;50000;H2020-SMEINST-1-2014;SME-1;MICHELL INSTRUMENTS LIMITED;UK;;; 196572;674724;VALIDIAG;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Validation Manager - A disruptive turnkey solution for diagnostic test validations;1/05/2015;31/10/2015;;"The need for fast and accurate diagnostics in laboratories is an exceedingly important global issue. It is a mandatory requirement by regulators that the performance of any new clinical diagnostics test must be thoroughly demonstrated, i.e. validated before it can be sold by the diagnostics companies, or taken in use by laboratories. Organizations may easily waste on average 100 000 a year for validations, which could be saved.

Finbiosoft (FBS) has introduced a unique and disruptive cloud-based (SaaS) software, Validation Manager, which makes validation of diagnostic tests according to requirements truly easy and is able to cut down even 95% of the time needed for validations. The software enables i) diagnostic companies to save dramatically time and money to reach markets faster, allowing them to sell more, and ii) laboratories to be able to cost effectively evaluate and take into use the best available diagnostics. The estimated market potential globally is 750 M.

Finbiosoft's ambition is to revolutionize industry practices and make its solution a de facto tool for managing validations globally in all diagnostics segments. FBS is the only player on the market offering a full turnkey solution, and holds a unique opportunity to grab the global leadership position in diagnostics validations.

In the project, FBS will assess the market potential and arising challenges when expanding from the first targeted segment, molecular diagnostics, to other segments like clinical chemistry. Upon completion of the project, FBS deeply understands requirements to commercialize its product to new segments regarding both technical and economic aspects with a plan to achieve the desired de facto status. The outcome is comprehensive business plan and knowledge of the full potential for the solution in Europe with a detailed road map and go-to-market model, crucial to provide direction to the next phase of development and the planned Horizon 2020 SME phase II application.";71429;50000;H2020-SMEINST-1-2014;SME-1;FINBIOSOFT OY;FI;;; 196652;663433;GULWESS-PROP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Green Ultra Light Weight Energy Storage System for Propulsion;1/02/2015;30/06/2015;;"GULWESS-PROP overall innovation project aims at designing a commercial solution of efficient on-board energy storage for electrically propelled vehicles. The main goal is to substitute on-board electrical batteries and hydrogen storage.

Drage&Mate International has a patented in-situ on-demand hydrogen generation process able to increase the total gravimetric energy density of the system. This improvement allows existing vehicles to multiply by 2 or even by 7 their existing range which means a very profitable new opportunity to market.

The current study will analyse how to progress to a commercial profitable product. To do that, GULWESS-PROP will validate the feasibility (technical, economic and operational) of the development and define a preliminary Business Plan.
The goal is to transform the prototype solution which is currently in a TRL6 development stage to TRL9 market commercial product by the end of phase 2.

Once GULWESS-PROP will be validated, a business chance will start-up to supply such technology to unmanned vehicles. In the close future similar system could be used in manned vehicles, and all kind of space vehicles. With this approach GULWESS-PROP will, at the end, lead a major impact within the decarbonised transportation goals in Europe.

Although the lightweight hydrogen storage segment counts with several competitors, GULWESS-PROP has a competitive advantage over the rest of solutions related to the user experience: the final users consider that is easier to operate thanks to reactor cartridge refillable concept.

Drage&Mate International is a Technology-Based high innovative company with proven track record within the hydrogen generation market; and with enough experience and ambition to turn the innovation of GULWESS-PROP into a sustainable product.";71429;50000;H2020-SMEINST-1-2014;SME-1;DRAGE & MATE INTERNATIONAL SL;ES;;; 196696;673030;iTampon;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Intimate, home-diagnostic tools for women;1/03/2015;31/08/2015;;"At Dr. Dolhay, our mission is to provide female hygiene and health products that serve the health of women and their sexual partners by use in the intimacy of the home.
The iTampon project involves an innovative method completely free of electronics to diagnose female health at home. These two novel diagnostic devices will enable women to detect the sign of any infection, indicating the need to turn to a gynaecologist. Additional examinations can be carried out by sending samples to our laboratory partner.
Early warning of potential diseases, such as cervical cancer or preterm birth, can save millions of lives, as women could undergo the necessary treatment in time.
The project originates from a business development idea to internationally expand our current, market-leading product lines. However, the development has convinced two EU-based companies to offer us EU-wide cooperation, once the products are qualified to be launched on the market.
The need for the products is well demonstrated, as it breaks through the key barrier women have against going to the gynaecologist: shyness and anxiety.
We have developed two prototypes that are essential diagnostic tools at the level of consumer goods keeping the intimacy of women using them:
1) Intelligent Tampon Observer (iT Observer): it is a pH meter (good flora indicator) which provides a pH-status map of the whole vagina and cervix.
2) Intelligent Tampon Collector (iT Collector): it is a 2in1 solution, a pH meter and home HPV/cancer test which enables women to perform a basic gynecological self-examination in the privacy of their home.";71429;50000;H2020-SMEINST-1-2014;SME-1;DOLHAY KLINIKA EGESZSEGUGYI KFT;HU;;; 196682;658592;NANOTAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development and Evaluation of Nanomedicines for Cancer Treatment through Immunomodulation: Targeting Tumor-Associated Macrophages;20/05/2015;19/05/2017;;"This project is focused on the development of novel nanomedicines effective in targeting the immunosuppressive, pro-tumoural, Tumour-Associated Macrophages (TAM) with the aim to manipulate the hosts immune system and improve anti-tumour responses. In most patients, chronic inflammation and immune suppression are the dominant effects in the tumour microenvironment. The infiltration of TAM in tumour tissues has been shown to support tumour growth, invasion and metastasis. Indeed, high density of TAM in tumours is correlated with resistance to therapies and poor prognosis. These findings establish TAM as promising targets of future anti-tumour therapies.

Here, we aim to design a series of Therapeutic Nanostructures (TNs), containing immunomodulatory or chemotherapeutic compounds, and conveniently functionalized, in order to target and re-educate or kill the TAM. These novel TNs will be composed of biodegradable polysaccharides, i.e. chitosan (CS) or hyaluronic acid (HA), and will be functionalized, with the aim to develop a series of targeting strategies to optimally reach TAM in vivo. These strategies involve the chemical linking of: (i) mannose residues expected to direct the TNs to the mannose receptors, highly expressed on the surface of TAM or (ii) the tumour lymphatic-specific peptide (LyP-1), known to have affinity towards NRP1 on TAM. The nanomedicines (TNs) will be loaded with pharmacological activators of TLR7 aimed to re-educate TAM into immunostimulatory anti-tumour macrophages. In the event that re-polarization of TAM is not satisfactory, or its effect is not long lasting in vivo, TNs will be loaded with chemotherapeutic drugs able to kill TAM. The TNs will be tested in vitro and in vivo to verify their effectiveness in switching back the pro-tumoural properties of TAM and their effect on tumour growth. We expect that this approach will enable greater progress in the treatment of tumours and ultimately lead to improved outcomes for cancer patients.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HUMANITAS MIRASOLE SPA;IT;;; 196543;673934;ZOONOMARKS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Development of simple to use point of care tests for zoonotic pathogens and their validation for use in clinical research setting;1/05/2015;31/10/2015;;"Our major goal is development of simple to use point of care tests for zoonotic pathogens and viral hemorrhagic fevers (VHF), and their validation for use in clinical research setting.
Zoonosis is any process whereby an infectious disease is transmitted between different species of animals. The term zoonosis is here used specifically to refer to diseases that originate in other species of animal, but that get transmitted to humans. Zoonoses in which humans are infected may originate in either domestic animals or wildlife, such as insects, mammals, reptiles, bats, or birds.
This application contains a draft business plan with feasibility study that verifies the technical and economic viability of the new diagnostics in the proposed clinical validation.
In phase 1 a comprehensive business plan will be produced aiming in phase 2 to develop a comprehensive rapid response diagnostic system for zoonotic pathogens and hemorrhagic fever viruses, with implications for surveillance of all emerging pathogens. Furthermore, in phase 2 the developed tests will be evaluated by end users of the tests by several research and clinical diagnostic laboratories.";71429;50000;H2020-SMEINST-1-2014;SME-1;OY REAGENA LTD;FI;;; 196621;644077;SLA-Ready;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;SLA-Ready: Making Cloud SLAs readily usable in the EU private sector;1/01/2015;31/12/2016;;"Today, whilst many organisations are reliant on cloud resources, contracts for cloud services often contain Service Level Agreements (SLAs) with technical & legal provisions that are inappropriate, difficult to understand &/or illegal. Similarly, the application of established data protection concepts can be problematic, with uncertainties as to what is regulated, who is responsible & which laws apply.
Building on the work conducted by EC SIG SLA, Certification & Code of Conduct, ETSI CSC, CSA WGs, ECP Steering Board, NIST, Gartner, SLA-Ready, delivers a reference model for Cloud SLAs & a set of best-practices & services to support cloud customers in the use of cloud SLAs through their life cycle. The latter will improve the uptake of cloud computing by private sector, while procuring services across the cloud market.
Other Outputs:
support cloud customers via a dedicated, social repository of Cloud SLAs and supporting services to ensure the acquisition, operation and termination of cloud services fulfilling specified requirements;
provide an active contribution to relevant SDOs like: ISO/IEC 19086.
engage & ensure coordinated, global collaborations with e.g., NIST RATAX and the CSA SLA WG for a collaborative, international approach;
Provide 4 engaging practical user friendly tutorials to end-users,
Showcase real efforts of the common reference model implementation in Europe.
The consortium is lean, complementary & strong: TRUST-IT, a prime mover in cloud computing landscape ensures effective coordination, digital marketing & SDO liaisons; CSA a leading, global player in the arena of cloud security; TUDA, brings direct expertise on techniques & frameworks to operate with cloud SLAs; Arthurs Legal represents IT, ISP, software, CSP, IoT & IT service vendors, end-users in their legal life cycle. Numergy offers cloud services to public & private organizations. SLA-READY has a pragmatic & actionable Advisory Board (AB) made up of key opinion leaders.";679936;679936;H2020-ICT-2014-1;CSA;TRUST-IT SERVICES LIMITED;UK;"ARTHUR'S LEGAL BV;CLOUD SECURITY ALLIANCE (EUROPE) LBG;NUMERGY SAS;TECHNISCHE UNIVERSITAT DARMSTADT";"NL;UK;FR;DE"; 196571;674718;BERTHA-G;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Bertha G - better enzymes - than gas;1/05/2015;31/10/2015;;"BERTHA-G stands for Better enzymes than gas. Our first-of-its-class system enables independence from centralized supply of fossil fuel (i.e. natural gas, oil) for residential heating purposes (15000 kWh therm. p.a).
Applied at a national level, our approach can help disrupt the conventional energy supply and shift the demand from limited oil / natural gas from external suppliers to synthetic fuels which are cost-efficient and non-volatile (price), not limited by nature and CO2 neutral.This will be achieved by a cutting-edge proprietary technology: using the platform technology of Gensoric GmbH, an electro-biocatalytical process converts plain water, CO2 from ambient air and electricity into preferably Methanol. In contrast to alternative CO2-to-fuel-technologies, this process runs under mild conditions: no high pressure, no high temperatures. Owing to the selectivity of the enzymatic process, CO2 can be taken from ambient air, there is no need for a refined or concentrated volume streams. All steps can be carried out at ambient conditions which makes it suitable for residential applications. All educts needed are available, even the electrolytic production of hydrogen can be waived, as the enzymes take the needed hydrogen directly from plain water.
The electrical energy can be taken from installed renewable energies, an effect which can make installed system more economically viable, especially for storing purposes, which will dramatically increase the efficiency. To facilitate the usage, our system is compatible to already existing infrastructure.
Through our solution, we empower the customer to become a prosumer or producer and consumer of energy to mitigate the volatility of energy prices, to become energy independent, and contribute to a CO2 neutral economy. In contrast to conventional device sellers, we can enhance the attractiveness of the underlying business model by introducing revolving sales through consumables.";71429;50000;H2020-SMEINST-1-2014;SME-1;GENSORIC GMBH;DE;;; 196651;663334;Colibri;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;The compact LIBS module for advanced materials analysis;1/01/2015;30/06/2015;;"Anteryon BV has a track record of more than 30 years in the R&D, manufacturing and marketing of refractive optical components and modules for a variety of niche market applications. Since 2010, Anteryon has been expanding in providing customized optical solutions for compact optical encoders and spectrometers. As a next step in this roadmap Anteryon envisages to accomplish a breakthrough in user access, size and cost reduction of a fast growing spectroscopic materials analysis technique, namely Laser-Induced Breakdown Spectroscopy (LIBS). The name Colibri stands for compact LIBS module for advanced materials. The novel Colibri module is carrier for a breakthrough in LIBS and will enable a more efficient, affordable, and more wide-spread use this spectroscopic technology for the analysis of materials. In this way, the increased use of LIBS will also contribute to the social themes and to the efficiency in executing European programs in the field of waste management, environmental protection, ecological footprint reduction, food safety control and health care.
The Colibri module is a novel architecture and manufacturing platform that will be available as a standard plug-in module for compact, cost-effective, robust reconfigurable and user accessible spectrometers.
The proposed Colibri module satisfies spectrometer users needs to measure in real-time and in-line without compromising the LIBS spectral accuracy and at affordable costs (at least 4 times lower than the state of the art). The Colibri module allows reconfiguration of the spectrometer for different applications by adapting software only. These features will boost the user accessibility and market size of affordable LIBS technology.
The feasibility assessment under Phase 1 will include a business plan including marketing plan, optimal price definition, funding strategies, technical feasibility, fabrication process, capital equipment, cost analysis, an IPR study and a risk and sensitivity analysis.";71429;50000;H2020-SMEINST-1-2014;SME-1;ANTERYON BV;NL;;; 196585;655394;ResMet;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Resampling methods for nonstationary stochastic processes;1/10/2015;30/09/2017;;ResMet is dedicated to applications of resampling methods in statistical inference for the processes with periodic and almost periodic structures. The mentioned processes in the literature are called cyclostationary (CS) and almost cyclostationary (ACS). Studies of CS/ACS processes started by Gladyshev in 1961. Since then the subject has developed fast and found applications in many branches of vibroacoustics, mechanics, signal analysis and climatology. The wide range of possible applications resulted in the thousands of papers that were published through the last 60 years. Unfortunately, the analysis of CS/ACS processes is very difficult. The most difficult is the estimation of the asymptotic covariance matrix for parameters of interest. In practice it is almost impossible and to construct confidence intervals resampling methods need to be used. The Experienced Researcher (ER) will show their consistency for different parameters of CS/ACS processes. Additionally, she will consider jitter effect and develop testing tools to detect the significant frequencies and to check if the considered data are zero-mean. These results will allow e.g. for construction of the new tools for machine faults detection. Moreover, new research topics will appear like choosing the optimal block length for each application. During the fellowship the ER will be able to work with the experts (her supervisor Prof. Dehay included) in the analysis of AC/ACS processes and in testing. The ER will join the seminars organized by them and will exchange the knowledge on the daily basis with other statisticians. Finally, she will present results of her work on the seminars, workshops and conferences. This process will allow her to finish her habilitation and apply for the permanent professor position in Europe. Moreover, during her secondment at Laser Analytica she will get statistical consulting experience, which in future will allow her for collaboration with pharmaceutical companies in Europe.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE RENNES II;FR;;; 196592;672558;TyRec process;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;TyRec process: Whole Tyre Recycling within 30 Minutes with Molten Zinc towards a circular economy;1/06/2015;30/11/2015;;"Composite Recycling Ltd has developed a unique, patented process to recycle tyres using molten zinc. Using molten zinc has a number of advantages over traditional processes:

Economic process as:
Speed of tyre destruction is just 30 minutes rather than 2-4 hours as in traditional rotary kiln processes.
No shredding / granulating; whole tyres, savings in capital and operational costs.
No scale-up issues: doubling the surface area of the molten material doubles the throughput.
Separation: the molten zinc is used to separate the steel and carbon black.

Every year over 1.5 billion tyres are discarded worldwide. Tyres are a composite plastic material and difficult to recycle, but they do contain value in their constituent raw materials such as oil, carbon black, copper and steel.

Because the process utilises existing, proven technologies from low cost industries such as the hot dip galvanising and the carbon black manufacturing industry the technological and hence commercial risk is minimised.

The tyre recycling process was proven to work as intended in collaboration with University College Cork. The next step is to construct a demonstration plant and to proof the recycling of the tyres on this scale providing customers with the confidence of investing into full scale plants.

For all the above waste streams the European and US legislators are increasing the pressure on industry to develop a solution, presenting an opportunity. At the same time a US government report suggests that the US requires up to 200 tyre recycling plants with the European market of similar size as the car ownership is similar.";71429;50000;H2020-SMEINST-1-2014;SME-1;COMPOSITE RECYCLING LIMITED;IE;;; 196528;673655;SPACE-DSP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;REPROGRAMMABLE GENERAL PURPOSE INSTRUMENT FOR DIGITAL SIGNAL PROCESSING IN SPACE;1/05/2015;31/10/2015;;"The emergence of reconfigurable FPGAs with space qualification opens up new opportunities in space missions. Until recently, implementing high-speed Digital Signal Processing (DSP) algorithms for space was only possible with anti-fusible technology devices. These devices are resistant to radiation but can be programmed only once. Up to now, this fact has determined the development of space instruments, as designs are optimized for a concrete functionality.

The system proposed herein is a general purpose instrument which is reprogrammable in orbit and multi-experiment. It has a programming memory that is remotely configured via radio link with Earth, so the functionality of the instrument can be totally modified from Earth. The DSP algorithms of the FPGA can then be updated or corrected depending on the space missions requirements or clients interests. It offers a completely new business outlook: the instrument can either be sold to companies that want to optimise the resources of their satellite or be rented and exploited by different companies in a multi-experiment distribution or validation hardware.

This document is to request a feasibility study according to phase 1 of the Common Conditions of Horizon 2020 and its dedicated Work Programme 2014-2015. In particular, it refers to SME-SPACE-1-2014/2015: SME instrument, and offers a transversal range of applicability within this topic. This feasibility study (phase 1 of SME instrument) will be guided by the Spanish company AD TELECOM and is expected to include other members and subcontracted members in a future phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;AD TELECOM SL;ES;;; 196556;674214;Cydar PaaS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Disrupting the real-time medical imaging market, and accelerating innovation, with cloud Platform as a Service (PaaS);1/05/2015;31/10/2015;;"Medical imaging science has progressed greatly in recent years with advances in cloud computing power, computer vision, machine learning and augmented reality. There is global political will to improve the efficiency of healthcare delivery through better exploitation of information technology. But there is surprisingly little translation of research output into clinical systems supporting real-time imaging.
Large hardware manufacturers currently dominate the software market for image-guided surgery. Their business model is based on high capital expenditure for installing large equipment that combines hardware and software. But this model means high costs and long lead times for changes, creating high barriers to innovation.
Cydar has identified an opportunity to disrupt this model by decoupling software innovation from the hardware. The concept is a dedicated cloud platform that hosts third-party applications, while handling image anonymisation, information security, governance and data storage. The core, tested technology involves a standard PC and web browser securely streaming the live imaging in the operating room to the cloud platform.
This business model is cloud Platform as a Service (PaaS), hosting applications for enterprises, healthcare organisations and academic institutions. Revenue streams include hosting fees and fees for access to the stored data for secondary use.
Crucially, end-user markets become widely accessible, costs are lowered, lead times slashed and the commercial risks of innovation reduced. The model is readily scalable for the global market. We expect it to accelerate the exploitation of medical digital data for the benefit of citizens, both as patients and as taxpayers.";71429;50000;H2020-SMEINST-1-2014;SME-1;CYDAR LIMITED;UK;;; 196695;672592;MgSpa;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;A highly efficient and eco-friendly electric shower offering health benefits through magnesium sulphate;1/05/2015;31/10/2015;;"According to reports by the US National Institutes of Health (NIH), most western populations are magnesium deficient. Magnesium deficiency can lead to a number of health problems such as high blood pressure, heart disease, stroke, osteoporosis and arthritis, to name only a few. Sulphate is also essential for many biological processes and at the same time sulfation is a major pathway in detoxifying drugs and environmental contaminants. According to the School of Biosciences of the University of Birmingham, sulphate is not easily absorbed across the gut wall. The recommended treatment up to now for absorbing these nutrients was bathing in Epsom salts, a procedure that calls for a considerable amount of time, water and electrical energy.
MgSO4 Ltd (UK) has developed and patented MgSpa, a new revolutionary alternative to electrical showers, which enables the user to quickly and effectively absorb the necessary Magnesium and Sulphate through the skin, while at the same time ensuring huge savings in water (97% less) and energy (80% less). The MgSpa makes the Epsom salt treatment an easy low cost everyday habit, like taking a shower.
The concept behind the product is to make use not only of the therapeutic properties of the salts, but also of their cleaning ability. So far, the use of soaps made water recirculation in showers impossible and the showers water and energy consumption significant. The innovative product uses Magnesium as a cleaning agent and recirculates and reheats shower water to create an invigorating shower experience with minimum environmental impact.
The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy and planning all activities for deploying a large scale pilot supported by a large hotel/spa chain. The partner SME Caleidos (Italy) will support the industrialization and marketing plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;MGSO4 LTD;UK;CALEIDOS GROUP SRL;IT; 196642;653965;AARC;SIGNED;H2020-EU.1.4.1.3.;EINFRA-7-2014;H2020;Authentication and Authorisation for Research and Collaboration (AARC);1/05/2015;30/04/2017;;"The goal of AARC is to address technical and functional gaps that prevent the interoperability of existing R&E AAIs.
AARC objectives are:
1. Deliver the design of an integrated cross-discipline AAI framework, built on federated access production services (eduGAIN)
2. Increase the uptake of federated access within different research communities
3. Pilot critical components of the proposed integrated AAI where existing production services do not address user needs
4. Validate the results of both the JRA and SA by engaging with the research communities

AARC goals will be achieved by:
Researching main technical (attribute providers, guest IdPs, support for non-web SSO) and policy aspects (level of assurance, security incidents, etc)
Supporting (commercial) services relevant to the R&E community
Delivering training to targeted user communities (e.g. libraries, biomedical, arts and humanities) on both technical and legal aspects

Relevance to the work programme:
1. Facilitate the deployment and promotion of a pan-European identity federation Met by:
Designing an AAI framework that builds on federated access and on the evolution of eduGAINs interfederation approach
Extensive dissemination of AARC results
2. Lower barriers to entry for organisations Met by:
Delivering tools to enable federated access for institutions, services and guest users (also meets obj. Allow for public access at large)
Delivering technical training tailored to institutions and services following the train-the-trainer model (also meets obj. Offer training and outreach for data professionals)
3. Overcome technical, organisational and legal obstacles Met by:
Policies and best practices for operational and security aspects for the integrated AAI
Training on legal aspects, built on experience with eduGAIN
4. Enable the interoperability of different AAIs Met by:
Models to offer collective services and to aggregate their accounting information
Pilots on security token";2950060;2941060;H2020-EINFRA-2014-2;RIA;GEANT VERENIGING;NL;"GROUPEMENT D INTERET PUBLIC POUR LERESEAU NATIONAL DE TELECOMMUNICATIONS POUR LA TECHNOLOGIE L ENSEIGNEMENT ET LA RECHERCHE;FORSCHUNGSZENTRUM JULICH GMBH;CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN;SURFSARA BV;JISC COLLECTIONS AND JANET LIMITED;STICHTING EGI;INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK;STICHTING LIBER;KARLSRUHER INSTITUT FUER TECHNOLOGIE;MORAVSKA ZEMSKA KNIHOVNA V BRNE;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;DAASI INTERNATIONAL GMBH;CONSORTIUM GARR;VEREIN ZUR FOERDERUNG EINES DEUTSCHEN FORSCHUNGSNETZES DFN VEREIN E.V.;CESNET ZAJMOVE SDRUZENI PRAVNICKYCH OSOB;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE;SURFnet bv";"FR;DE;FI;UK;NL;PL;CZ;CH;IT;EL"; 196579;640868;SWInG;SIGNED;H2020-EU.3.3.5.;LCE-01-2014;H2020;Development of thin film Solar cells based on WIde band Gap kesterite absorbers;1/06/2015;31/05/2018;;"The aim of this proposal is to develop wide band gap thin film solar cells based on kesterite absorbers for future application in high efficiency and low cost tandem PV devices. The SWInG working group will focus both on the development of the processes for the synthesis of such solar cells based on the Cu2ZnXY4 (with X=Sn, Si and Y= S, Se) compounds and on the understanding of the physical and electrical properties of the high band gap absorber in order to reach high conversion efficiency. The key research challenges will be: developing up-scalable processes for the synthesis of the absorbers; defining the specifications for high quality wide band gap absorbers as well as suitable back contact and buffer/window layers; assessing the potential of this technology for PV applications. The wide band gap thin films solar cells developed in this project are expected to reach a stable efficiency of 15 % on a laboratory scale and 12 % for a mini-module prototype. The publications of specifications for the synthesis of high quality Cu2ZnXY4 absorber as well as suitable back/front contact are expected. The lead users will be PV modules manufacturers that work so far with thin films technologies, as well as the companies that design and produce the machines for the synthesis of such devices. The results will be disseminated and communicated to the European PV industries and the scientific community. The intensive exchange of researchers between the partners during the project will also lead to an enhanced European collaboration in the research field of thin film solar cells.";3254755;3254755;H2020-LCE-2014-1;RIA;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;"NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;UNIVERSITEIT GENT;ZENTRUM FUR SONNENENERGIE- UND WASSERSTOFF-FORSCHUNG BADEN-WURTTEMBERG;MIDSUMMER AB;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH";"NL;BE;DE;SE;FR"; 196619;643803;PROEIPAHA;SIGNED;H2020-EU.3.1.;HCO-01-2014;H2020;PROEIPAHA: Coordination, Support and Promotion activities in favour of EIPAHA;1/01/2015;31/12/2016;;"The goal of PROEIPAHA CSA is to help addressing the challenges identified by the stakeholders and the experts group report, by providing a wide range of high quality support services for the EIPAHA, from secretariat services, R&I facilitation, policy guidance, awareness and stakeholders engagement support, fostering open and sustainable collaboration.

In order to pursue this goal, the project adopts a two-tier approach: internally, to reinforce the activity, output and impact of the EIP AHA, and externally, to increase its influence as a policy catalyser in the wider European economy. In other words, the project aims at improving the internal collaboration of the EIPAHA, and to widen its external outreach and influence.

The project is not designed as a coordination of EIPAHA, but as a set of support actions to the existing structures of governance, such as coordinators and thematic networks, in order to provide the tools and methodologies to help them deliver the expected results.

The consortium is composed by a balanced set of organization to provide high quality support services to the existing and future Action Plans, identifying synergies across AGs, and providing expert knowledge on Research and Innovation on active and healthy ageing (in wide range of domains impacting the issue), policy and legislation, monitoring, standardization, innovative procurement, knowledge sharing tools and governance methods, plus dissemination and awareness activities.";1949997;1949997;H2020-HCO-2014;CSA;FUNKA NU AB;SE;"European Regions Research and Innovation Network;NHG CONSULTING OY;OPEN EVIDENCE;PAU EDUCATION SL;FUNDACION TECNALIA RESEARCH & INNOVATION;SWEDISH ICT RESEARCH AB;RESEAU DES ACHETEURS HOSPITALIERS D'ILE-DE-FRANCE GIP - RESAH;INOVAMAIS - SERVICOS DE CONSULTADORIA EM INOVACAO TECNOLOGICA S.A.;REGION MIDTJYLLAND;ASOCIACION ESPANOLA DE NORMALIZACION;EUROPEAN HEALTH MANAGEMENT ASSOCIATION LIMITED;TEKNOLOGIAN TUTKIMUSKESKUS VTT;OUTSIGHT S.L.U;Teknologian tutkimuskeskus VTT Oy";"BE;FI;ES;SE;FR;PT;DK;IE"; 196650;663185;ANGELS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Advanced Next GEneration Landing System;1/01/2015;31/05/2015;;"Life matters. Safety matters. Economy matters. We all acknowledge that any action leading to diminish the risk of accidents must be promoted . A special situation arises in offshore platforms, where helicopter approach and landing (A&L) operations are far from being secure (300 accidents between 2000 and 2005). More than 75% of accidents between 1975 and 2001 occurred during A&L, being most of them (66%) related with installation design (obstacles dense), and most causes related with human errors and bad weather.
This project focuses on increasing safety the EU way, through an innovative use of carrier technologies encouraged by EU SESAR program. PALU follows these guidelines to disrupt the market of A&L high precision guiding systems with a product that will make our young, ambitious and innovative StartUp the provider of reference. 90% offshore wind farms are located in Europe so we are contributing substantially to the safety of our installations and our workers. Also, O/G rigs in the North Sea lead the rate of accidents (mostly because of bad weather), and we intent to help minimizing this rate.
Apart from the human drama, there is also the strong economic impact of losing highly specialized personnel (rate of casualties is >75% when a helicopter accident occurs), helicopters ($15-$25 million on average) and cargo. Even in the absence of incidents, aborting an A&L operation has a significant economic impact (fuel, salaries, impact of cargo delayed, etc.).";71429;50000;H2020-SMEINST-1-2014;SME-1;PALU SRL;IT;;; 196681;656753;GLASUNTES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Innovative high temperature thermal energy storage concept for CSP plants exceeding 50% efficiency;1/05/2016;30/04/2019;;"Energy provision is a big challenge for our Society, being the present production/consumption paradigm not sustainable. To change current trends, a large increase in the share of Renewable Energy Sources (RESs) is crucial. The effectiveness of Thermal Energy Storage (TES) poses Concentrated Solar Power (CSP) systems at the forefront, as the first dispatchable option among all intermittent RESs. In order to realize the CSP potential, the efficiency of the adopted Power Conversion Units (PCUs) must grow over 50%, entailing temperature levels of the order of 1000 C: promising solutions are based on Brayton thermodynamic cycles. This project stems from the observation that no existing TES option can be coupled to such PCUs and/or work at these temperatures, and aims at filling this gap. Three interrelated research objectives are proposed, to prove the feasibility and assess the potential of
1. an innovative CSP concept whereby (i) the receiver is co-located with the TES vessel, (ii) the solar radiation is directly absorbed by the liquid storage medium, and (iii) the thermal power is withdrawn from the TES by bubbling a gas through it, which can thus be used as working fluid in a Brayton cycle. An efficient and simple system results, without irradiated metal tubes, secondary fluid loops, heat exchangers, valves, nor pumps;
2. the adoption of common glass-forming compounds as novel TES materials. These are nontoxic and inexpensive (mainly sand), and the related know-how is already available from the glass manufacturing field, whose deep synergies with the CSP sector will be explored in a multi-disciplinary perspective;
3. the CSP systems resulting from the integration between receiverTES and PCUs.
The envisaged approach combines advanced theoretical and experimental research activities to achieve these goals. The final scope is to inaugurate a new branch in the field of solar systems, with the potential of enabling the CSP plants we need to ensure a bright Future.";259558,2;259558,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITA DI PISA;IT;;; 196513;673561;MD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Rapid monitoring of biomarkers in postoperative care;1/05/2015;31/10/2015;;"Colorectal cancer is the third most common cancer in the world, with nearly 1.4 million new cases diagnosed in 2012. The frequency of complications after surgery is relatively high, but rapid and safe monitoring methods are missing.

MD Biomedical AB has addressed this need and developed a radically new and innovative piece of medical equipment that is gently attached on the surface of the bowel for sampling of biomakers. This makes it possible to detect complications within minutes, at an early stage of illness, and long before patient systemic indications.

The possibility of rapid counteractions improves the treatment of the patient and save health care costs.

The feasibility study comprises one work package divided in 6 tasks and shall in measurable terms assess the functional, medical, economic, and environmental effects and the deliverable is a feasibility report including a business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;MD BIOMEDICAL AB;SE;;; 196632;645782;ERA-LEARN 2020;SIGNED;H2020-EU.3.6.;INSO-7-2014;H2020;Strengthening joint programming in Europe;1/01/2015;31/12/2017;;"Building on the ERA-LEARN, NETWATCH & JPIs To Co Work predecessor projects ERA-LEARN 2020 will provide an integrated framework to make P2P more efficient and effective and support national and regional funding organisations in the preparation, implementation and monitoring of joint actions.
ERA-LEARN 2020 will increase mutual learning within the P2P community and will thereby support the implementation of streamlined mechanisms. Useful input will be provided towards the analysis and possible future development of P2P formats. ERA-LEARN 2020 will highlight synergies between different forms of national/regional programme coordination and facilitate high-level analysis of P2P policy-related issues. It will provide tools for analysis and communication formats for supporting future developments of transnational programme coordination.
The ERA-LEARN 2020 team is highly qualified & complementary with national authorities and experts for analysis with many years experience of P2P at both the operational and policy levels.
ERA-LEARN 2020 will:
1. provide a web-based information, learning and support platform for P2P to avoid duplication of efforts;
2. support the ongoing optimisation of P2P networks by providing a toolbox for the wider activities of joint programming, particularly the JPIs, Art.185 and ERA-NET Cofund instrument, as well as their associated impacts;
3. implement a systematic process for monitoring & impact assessment of P2P networks, including their impacts at both the policy, programme and co-funded RTD project-level;
4. assess and benchmark current approaches to alignment and explore options for new modalities to better align national and/or regional activities under common research agendas;
5. implement an annual cycle of knowledge exchange aimed at increasing the impact of investment in P2P activities and exploring options to support less research intensive countries.";3199312;3199312;H2020-INSO-2014;CSA;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;AT;"OPTIMAT LIMITED;DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;THE UNIVERSITY OF MANCHESTER;VDI/VDE INNOVATION + TECHNIK GMBH;MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITA' E DELLA RICERCA;ENTERPRISE IRELAND;SUOMEN AKATEMIA;NORGES FORSKNINGSRAD;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE";"UK;DE;AT;IT;IE;FI;NO;FR"; 196541;673922;SDN-Polygraph;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Cloud-based Visibility Service for Software Defined Networks;1/04/2015;31/10/2015;;"Today, enterprises depend on the Internet and computer networks. Costs associated to network malfunctions are huge, estimated around 30K/hour; companies average 175 hours of downtime per year, which yields losses above 5 M/year per company. To avoid these huge costs, network administrators require network visibility: the ability to understand what happens in a network. Thus, companies are investing in visibility tools; the market of Network Performance Monitoring (NPM) is currently estimated at $2.4Bn, growing at >11% yearly.

However, enterprises today are still not investing as much as they should in network visibility, because of (1) deployment complexity, which requires expert technicians and planned interventions, and (2) high upfront costs of both hardware and software-based solutions.

A revolution in the networking world called SDN is currently undergoing. This new technology allows software components to alter the network, which becomes almost programmable. This opens a window of opportunity to create a SDN visibility product that removes both barriers: it can be deployed with one click, offered cheaply from the cloud at scale, and billed on a subscription basis. The market of SDN is currently $3.5Bn and will grow 10x until 2018. We believe that by combining SDN and network visibility we can at least double the market of our segment, increasing it by $2.4Bn.

The objective of this project is to refine our current Business Plan and reduce the uncertainties in the project. By reducing risk, we will consolidate it and open it to further investment. In particular, we will seek an early adopter and refine the value proposition of our first version of the product.

We are a company that commercializes network visibility solutions; our product (unrelated to SDN) is currently in commercialization stage, with many large-scale deployments. We therefore have the technical and business expertise to build and commercialize a novel network visibility product.";71429;50000;H2020-SMEINST-1-2014;SME-1;TALAIA NETWORKS SL;ES;;; 196641;653477;ASTERICS;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-4-2014-2015;H2020;Astronomy ESFRI and Research Infrastructure Cluster;1/05/2015;30/04/2019;;ASTERICS (Astronomy ESFRI & Research Infrastructure Cluster) aims to address the cross-cutting synergies and common challenges shared by the various Astronomy ESFRI facilities (SKA, CTA, KM3Net & E-ELT). It brings together for the first time, the astronomy, astrophysics and particle astrophysics communities, in addition to other related research infrastructures. The major objectives of ASTERICS are to support and accelerate the implementation of the ESFRI telescopes, to enhance their performance beyond the current state-of-the-art, and to see them interoperate as an integrated, multi-wavelength and multi-messenger facility. An important focal point is the management, processing and scientific exploitation of the huge datasets the ESFRI facilities will generate. ASTERICS will seek solutions to these problems outside of the traditional channels by directly engaging and collaborating with industry and specialised SMEs. The various ESFRI pathfinders and precursors will present the perfect proving ground for new methodologies and prototype systems. In addition, ASTERICS will enable astronomers from across the member states to have broad access to the reduced data products of the ESFRI telescopes via a seamless interface to the Virtual Observatory framework. This will massively increase the scientific impact of the telescopes, and greatly encourage use (and re-use) of the data in new and novel ways, typically not foreseen in the original proposals. By demonstrating cross-facility synchronicity, and by harmonising various policy aspects, ASTERICS will realise a distributed and interoperable approach that ushers in a new multi-messenger era for astronomy. Through an active dissemination programme, including direct engagement with all relevant stakeholders, and via the development of citizen scientist mass participation experiments, ASTERICS has the ambition to be a flagship for the scientific, industrial and societal impact ESFRI projects can deliver.;14991194;14991194;H2020-INFRADEV-1-2014-1;RIA;STICHTING ASTRON, NETHERLANDS INSTITUTE FOR RADIO ASTRONOMY;NL;"RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG;INSTITUTO DE FISICA DE ALTAS ENERGIAS;Friedrich-Alexander University (FAU) Erlangen-Nrnberg;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;STICHTING VU;ISTITUTO NAZIONALE DI FISICA NUCLEARE;THE UNIVERSITY OF EDINBURGH;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN;STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY;JOINT INSTITUTE FOR VERY LONG BASELINE INTERFEROMETRY AS A EUROPEAN RESEARCH INFRASTRUCTURE CONSORTIUM (JIV-ERIC);INSTITUTO NACIONAL DE TECNICA AEROESPACIAL ESTEBAN TERRADAS;INSTITUT D'ESTUDIS ESPACIALS DE CATALUNYA FUNDACION;GTD SISTEMAS DE INFORMACION SA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;ISTITUTO NAZIONALE DI ASTROFISICA;THE OPEN UNIVERSITY;UNIVERSITEIT VAN AMSTERDAM;UNIVERSIDAD COMPLUTENSE DE MADRID;SURFnet bv;UNIVERSIDAD DE GRANADA;JOINT INSTITUTE FOR V.L.B.I. IN EUROPE (J.I.V.E.)";"DE;ES;UK;NL;IT;FR"; 196544;673939;SIMPLE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Spacefibre IMPLementation design test Equipment;1/05/2015;31/10/2015;;"The forthcoming European Space missions both for earth observation and science (e.g. Euclid, Metop-SG) are more and more demanding very high-speed data transmission (above Gbps) within the different units in satellite payloads and platform. As SpaceWire standard (ECSS-E-ST-50-12C) is no longer capable to meet such stringent requirements the European Space Agency (ESA) is finalizing a new standard for high-speed data links called SpaceFibre. Among the main features SpaceFibre defines high reliable and fast point-to-point or network connections
The definition of this new standard opens up a considerable business opportunity related to the implementation of Intellectual Property (IP) and systems compliant to it. In order to guarantee a high reliable transmission the SpaceFibre is rather complex, thus 2 main issues are expected to be faced by any developer: on one side the design and implementation of a system compliant with the standard and on the other side the need for a test equipment capable of validating such a design.
The proposed innovation project has the ambitious goal to solve both the problems by:
1) Design, Development and Testing of a point-to-point interface controller IP, both synthesizable HW macrocell and relevant SW/Firmware, compliant with the new High Speed Serial Link standard developed by ESA under the name of SpaceFibre;
2) Development of a test equipment (SpaceFibre Analyser) based on the outcome of the previous activity which serves as reference equipment for testing any design/product related to SpaceFibre.
The final aim of the project is to provide the customer with a powerful instrument to simplify the development of his own system based on SpaceFibre technology, thus the acronym SIMPLE.
The company IngeniArs through the commercialization of the SpaceFibre technology is aiming to achieve 10% of the forecasted market size reaching a positive EBITDA during the first year of product commercialization and reaching the breakeven after 2 years.";71429;50000;H2020-SMEINST-1-2014;SME-1;INGENIARS SRL;IT;;; 196631;645775;DRAGON-STAR Plus;SIGNED;H2020-EU.3.6.;INT-01-2014;H2020;Dragon - Sustaining Technology And Research Plus (EU-China Collaboration);1/02/2015;31/01/2018;;"China is already an important global actor in the fields of research and innovation, and has the potential of becoming a leading force in the next few decades. The shift in Chinas strategy focusing towards R&I and transforming the essence of its economy has been complimented with massive public investments in research and technology. The EU having recognised the leading role China is expected to play, and having adopted a strategic position for becoming a knowledge-based economy, is required to collaborate with China in areas of mutual interest, and for common benefit and prosperity. Moreover for critical global issues which demand close scientific and technological cooperation at an international level, EU has identified in China a natural partner able to contribute and complement its own capacity.
The proposed initiative aims to provide support services to European and Chinese researchers, and a flexible platform to facilitate policy discussions between European and Chinese stakeholders. Moreover, DRAGON-STARPLUS will provide the EC and the Member States with a toolset for setting a long term cooperation strategy in research and innovation with China.
The project aims to provide efficient services on three levels (priority areas):
- Support the European and Chinese research communities to establish collaborations under Horizon 2020 and beyond.
- Provide a cooperation platform and tools to policy makers, aiming ultimately to support and enhance the bilateral cooperation, through the concept of mutual benefit.
- Provide an ERA-NET style platform to funding agencies for exchanging best practices and planning joint activities.
The proposed activities take into account the current on-going policy dialogue and the peculiarities of the research and innovation environment in China, and are based upon the outputs and the established mechanisms of the previous DRAGON-STAR project, as well as upon the sound results of previous related projects (e.g. OPEN-ICT, CO-REACH).";2227812,5;1949999,5;H2020-INT-INCO-2014;CSA;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;"SIGMA ORIONIS SA;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;China Science and Technology Exchange Center;CHINA AGRICULTURAL UNIVERSITY;SOCIEDADE PORTUGUESA DE INOVACAO - CONSULTADORIA EMPRESARIAL E FOMENTO DA INOVACAO S.A.;KAIROS FUTURE AKTIEBOLAG;EMETRIS SYMVOULOI ANAPTYXIS ORGANOSIS KAI PLIROFORIKIS AE;EURELATIONS AG;THE UNIVERSITY OF NOTTINGHAM NINGBO;STEINBEIS INNOVATION GGMBH;BEIJING SOFTWARE ENTERPRISE ADVISORY CENTER;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA";"FR;AT;CN;PT;SE;EL;CH;DE;IT"; 196570;674655;InLineNano;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;In-Line Areal Surface Measurement for Micro and Nano Production;1/05/2015;31/10/2015;;A new optical interferometry technology has been developed which delivers fast and high precision areal surface measurements for stepped and structured micro-nanoscale surfaces which cannot be measured by traditional techniques. The technology addresses the market need for high throughput, simple sample preparation and nanoscale accuracy combined with an affordable system cost. Furthermore, a unique vibration isolation innovation means that it has the flexibility to be applied both in-line and in-process. This project aims to validate its commercial potential as both a research and industrial metrology tool.;71429;50000;H2020-SMEINST-1-2014;SME-1;IBS PRECISION ENGINEERING BV;NL;;; 196640;653066;PGE-PLANETS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mineral scale platinum-group-element osmium isotope constraints on planet formation late accretion;20/07/2015;19/07/2017;;"Platinum group element (PGE) abundances & 187Os-isotope compositions determined for magmas of Earth, the Moon, Mars, & asteroidal bodies place important constraints on planetary evolution but these data, & current analytical approaches, have largely focused on whole-rock analyses. Interpretations of planetary PGE fractionation & parent-body mantle reservoir compositions often appeal to knowledge of PGE fractionation reported for Earths magma compositions that may differ from other planetary melts. For these reasons significant uncertainty exists on the internal influences of planetary bulk-rock PGE compositions & inferred mantle reservoir characteristics.
We propose to pioneer analytical techniques that will enable the first comprehensive study of mineral-scale PGE abundances & 186,187Os-isotope compositions in selected differentiated & primitive achondritic meteorites. This new quantitative mineral-scale information will enable rigorous & comprehensive assessment of the nature of planetary PGE fractionation(s), the degree of internal Os-isotopic equilibrium, & more precise knowledge of Osi values - thereby advancing understanding of molecular to planet-scale PGE characteristics with implications for theories concerning planetary & Solar System evolution.
For the purposes of the proposed research the Fellow has secured access to the University of Alberta Meteorite Collection; >1100 planetary samples curated by one of Canadas foremost meteoriticists (Prof. C.D.K. Herd). The researcher benefits from 4.5 years of postdoctoral experience where she advanced her expertise in PGE analytical chemistry in specialist laboratories at leading North American institutions. Her experience of handling precious meteorite materials & familiarity with laser-ablation protocols & micro-column chemistry are key assets to the proposed study to be conducted at the University of Durham, a European & global leader in PGE analyses.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Durham;UK;;; 196587;656047;EinsteinVRH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Einstein Relation for the Variable Range Hopping model;1/02/2016;31/01/2018;;"The Variable Range Hopping is considered in the Physics literature as an effective model for the analysis of conductivity in semiconductors. Understanding how the macroscopic parameters depend on the small-scale randomness of the environment and proving the Einstein Relation for this model is the ambitious aim of this project.

Main objectives:

1) Extend recent results (law of large numbers, existence of a stationary state) for long-range reversible random walks on point processes including the possibility of traps.

2) Analyze how an external field influences the limiting velocity of the Variable Range Hop- ping, in comparison to similar models from Mathematical Physics.

3) Establish the first rigorous Einstein Relation for a physically relevant model, the Variable Range Hopping.

The mathematical techniques we have at our disposal nowadays (such as the weak Einstein Relation and the control of long range models) are a solid basis for the investigation of the problem: This would be the first time an Einstein Relation is rigorously proven for a relevant physical model. Furthermore, the richness of the subject guarantees also many intermediate results of great relevance in the field of Probability Theory.

Besides the big scientific relevance of the expected results, the project will have a strong impact also on the career of the experienced researcher, completing his international profile of independent scientist, and will also strengthen the interplay between the Probability Theory communities of France, Germany and Italy. Finally, a positive outcome of the action will bring a significant insight on the physical study of semiconductors.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PARIS DAUPHINE;FR;;; 196596;674161;DGC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;SEPA in your pocket development of a mobile payment solution based on a disruptive SEPA (Single Euro Payments Area) Credit Transfer approach for banks and the payment industry.;1/06/2015;30/11/2015;;"By empowering European banks and other payment specialists, Digicash Payments is providing the technology to truly revolutionise payment and shopping experiences: a direct link with the bank is now available directly on the consumers smartphone or virtually in their pocket. By triggering SEPA Credit Transfers, the Digicash solution serves as a technological channel between the end user (buyer/seller) and its primary source of financing providing an easy means to handle payments via a mobile device.

Being a bank-centric product in a highly competitive market, Digicash aims to impose the most efficient m-payment model on the European market together with banks. Digicash provides leading-edge technology by commercialising a white-label solution based on SEPA Credit Transfers that is entirely customisable, for both design and functionality.

The solution allows banks to offer additional banking services and enhance their relationship with their clients offering bank-grade security and compliance levels. Thus, Digicash enables them to offer 1/ consumers a convenient, secure and trustworthy payment solution with enhanced value-adding services and incentives, and 2/ merchants a true added value, speeding up their point of sale processes, enhancing the sales experience by integrating features, and reducing merchant commissions based on a less costly infrastructure. For banks, this is a real opportunity to drive innovation in a changing consumer-driven environment.

Digicash Payments aims at becoming a leading European premium payment technology provider for the financial industry based on the launch of a product suiting the specific needs of European banks. The main mission of the feasibility study intended to be undertaken under Phase 1 will be to create an exhaustive business plan within the next 6 months to prepare this internationalisation.";71429;50000;H2020-SMEINST-1-2014;SME-1;DIGICASH PAYMENTS SA;LU;;; 196527;673677;Efficient Cooking;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Substainable and efficient food processing and cooking sytem;1/05/2015;31/10/2015;;Natural Machines is a SME that has created the first 3D food printer that works with sweet and savory ingredients. We are focused on helping people get back to home cooking, back to healthy food, by bringing the food processing plant to the home kitchens, giving an eco-efficient alternative to traditional food processing, reducing food waste to zero and with significant savings in energy and packaging needed with no need to spend time cooking or knowing how to do it. Following the lean startup model, we introduced a model for B2B customers that allow them to create dishes, decorations, customizations, suitable for hospitals, restaurants, bakeries, etc. In order to get our product to the home kitchens, users have requested two main features that go far beyond 3D printing technology. The two systems are a new cooking technology that uses just a fraction of the energy used by traditional ovens and microwave ovens and a prefilled capsule system. Both systems working together will convert our new device in an optimised sustainable mini food processing plant at home. The cooking system provides a very granular control of the temperature of the food being cooked, allowing to preserve the nutritional properties of the ingredients and cook according to the user tastes. This system can work also as a standalone device, which opens also new OEM and licensing opportunities for our company. It provides also a safer operation, as no element in the device will be heated to a point of causing harm, as compared to an oven. From a business perspective, reaching the mass market (home kitchens) will allow us to more tan double current revenue forecasts according to initial interest in USA, Europe and Asia, and to introduce new business models, like capsule licensing that will generate new revenue sources. We expect the feasibility study to provide us with a better market insight and a complete business plan for bringing our device to the market.;71429;50000;H2020-SMEINST-1-2014;SME-1;2 VEGAN NATURAL MACHINES S.L.;ES;;; 196680;653838;PRACE-4IP;SIGNED;H2020-EU.1.4.1.3.;EINFRA-4-2014;H2020;PRACE 4th Implementation Phase Project;1/02/2015;31/12/2017;;"PRACE, the Partnership for Advanced Computing, was established in May 2010 as a permanent pan-European High Performance Computing service providing world-class systems for world-class science. Six systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 9 billion core hours of compute time. HPC experts from twenty-five member states - funded in part in three implementation projects - enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is preparing for PRACE 2.0, the successor of the initial five year period.
The objectives of PRACE-4IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2.0; strengthening the internationally recognised PRACE brand; continuing advanced training which so far provided more than 15.000 person-training days to over 4700 persons, preparing strategies and best practices towards exascale computing, coordinating and enhancing the operation of the multi-tier HPC systems and services, and supporting users to exploit massively parallel systems and novel architectures.
The proven project structure will be used to achieve each of the objectives in six dedicated work packages. The project will continue to be managed by Jlich.
The activities are designed to increase Europe's research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and special offers to SMEs; analysing new flexible business models for PRACE 2.0; proposing strategies for deployment of leadership systems; collaborating with the ETP4HPC, the coming CoEs and other European and international organisations on future architectures, training, application support and policies.";16354408,25;15000000;H2020-EINFRA-2014-2;RIA;FORSCHUNGSZENTRUM JULICH GMBH;DE;"CINECA CONSORZIO INTERUNIVERSITARIO;THE CYPRUS RESEARCH AND EDUCATIONAL FOUNDATION;CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY;THE UNIVERSITY OF EDINBURGH;PARTNERSHIP FOR ADVANCED COMPUTINGIN EUROPE AISBL;UNINETT SIGMA2 AS;Uppsala universitet;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;KOBENHAVNS UNIVERSITET;GRAND EQUIPEMENT NATIONAL DE CALCUL INTENSIF;UNIVERSITAT LINZ;NATIONAL UNIVERSITY OF IRELAND, GALWAY;SURFSARA BV;Gauss Centre for Supercomputing (GCS) e.V.;KORMANYZATI INFORMATIKAI FEJLESZTESI UGYNOKSEG;INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK;VYPOCTOVE STREDISKO SLOVENSKEJ AKADEMIE VIED;UNIVERSIDADE DE COIMBRA;UNIVERZA V LJUBLJANI;ISTANBUL TEKNIK UNIVERSITESI;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;MACHBA - INTERUNIVERSITY COMPUTATION CENTER;ASSOCIATION ""NATIONAL CENTRE FOR SUPERCOMPUTING APPLICATIONS"";NEMZETI INFORMACIOS INFRASTRUKTURA FEJLESZTESI IRODA;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE;VYSOKA SKOLA BANSKA - TECHNICKA UNIVERZITA OSTRAVA";"IT;CY;FI;UK;BE;NO;SE;ES;DK;FR;AT;IE;NL;DE;HU;PL;SK;PT;SI;TR;CH;IL;BG;EL;CZ"; 196583;648831;MyNano;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients;1/07/2015;30/06/2020;;"Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory patients and reduced drug-related toxicity. However, there is a growing concern on patient variability regarding tumor patho-physiology that underlie successful therapeutic outcome. Specific biomarkers are required to select those patients most likely to show good clinical response to these therapies.
The objective of MyNano is to engineer polymer-based combination therapies designed to treat metastatic breast cancer in a patient personalised manner. Therefore, novel multicomponent polymer conjugates with precise control over size, shape, solution conformation, multifunctionality and bioresponsiveness will be obtained while in parallel their structure activity relationships to underlying proposed mechanisms of action in clinically relevant models will be studied. Polyglutamates obtained by controlled polymerisation and self-assembly strategies will be the carriers. Primary breast cancer patient tissue will be used to generate cell and in vivo models representing different clinical molecular subtypes. MyNano will also investigate new combination strategies using current treatments together with inhibitors of tumor-derived exosome release pathways, phenomenon related to metastasis and resistance mechanisms.
The aim is to provide a novel methodological approach that would allow by reiterative design to optimise the design of the next generation nanoconjugates for the treatment of specific metastatic cancer clinical subtypes. MyNano will be a breakthrough as it introduces a paradigm shift in the strategy to design nanomedicines in areas of unmet clinical need.";1724168,97;1724168,97;ERC-2014-CoG;ERC-COG;FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE;ES;;; 196630;645730;CLUSDEV MED;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Cluster Development Med;1/06/2015;31/05/2019;;"The proposal lies within priority research & innovation topics in EU-Mediterranean cooperation, as highlighted in several past projects and policies reccomendations, i.e. within the MOCO - Monitoring Committee for Euro-Mediterranean Cooperation in RTD. International Cluster Cooperation offers opportunities to scal up research and technological potential, enhance competitiveness, support the regional socio-economic development and reinforce the market placement of new, innovative products. These cooperation approaches often fail due to constraints on resources, capabilities, instruments and funding. On the other hand, over 2.000 Clusters only in the European Union covering all sectors and able to realize an intersectorial framework, as well as related clusters and networks in the southern Mediterranean countries, form a great potential for transnational clustering.

The EUs framework for state aid defines innovative clusters as follows: Innovation clusters mean grouping of indipendent and innovative start-ups, small, medium and large undertakings as well as research organizations operating in a particular sector and region, and designed to stimulate innovative activity by promoting intensive interactions, sharing of facilities and exchange of knowledge and expertise, and by contributing effectively to technology transfer, networking and information dissemination among the undertakings in the cluster.
Taking into account the current socio-economic situations ClusDevMed priority topics are, in particular:
- Agribusiness, agro food, food security Energy - Water

Core research areas is: Green Tech in the field of Clustering Activities";796500;796500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DEGLI STUDI ROMA TRE;IT;"ISTANBUL TEKNOKENT ANONIM SIRKETI;DISTRETTO AGROALIMENTARE REGIONALE SCRL;UNIVERSITEIT UTRECHT;REDINN SRL;VILNIAUS GEDIMINO TECHNIKOS UNIVERSITETAS VIESOJI ISTAIGA";"TR;IT;NL;LT"; 196529;673676;bionic agitator;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Feasibility study of a bionic agitator a prototype of this agitator has shown great potential for energy reduction of agitator technology.;1/05/2015;30/04/2016;;"A prototype of a newly developed agitator has shown great potential for energy reduction in agitator technology. The developed agitator was inspired by the way ducks move their feet in the water a very energy-efficient way. Consequently we call the new agitator a bionic agitator. Now we want to validate the findings from the test of the prototype in a beta-phase test.
The idea to question the current agitator technology arose, while analysing the reasons for small biogas plants (<75kW, operating on organic waste) not being profitable. Martin Falger, the inventor of the bionic agitator and major shareholder of the wusoa GmbH, focused on the fact, that the highest fraction of the primary energy consumption of a biogas plant is needed for the agitator used in the same plant. The prototype of the bionic agitator has shown the potential to reduce this energy consumption by 60 per cent or more. Thus more of the produced energy in the biogas plant can be fed into the grid. As a result of this increase in the effective output it becomes more attractive to generate energy from organic waste which means a 100% carbon neutral way of energy production and a great contribution to the EU goals of reducing emissions by 80% in 2050.
The proposed feasibility study includes a field test where the bionic agitator is installed in five existing biogas plants. One additional bionic agitator will be installed in the biogas plant of the University of Hohenheim (Stuttgart, Germany) to test it against a conventional agitator. The aim of the feasibility study is to obtain reliable data on the energy reduction, the material used and to get a solid feedback from potential customers.
We estimate that the European market for agitators in the biogas industry is approx. worth 2.7 billion euro. However the bionic agitator cannot only be used in the biogas industry the energy savings make it attractive for any industry where fluids need to be stirred or mixed.";71429;50000;H2020-SMEINST-1-2014;SME-1;WUSOA GMBH;DE;;; 196557;674298;PFMaker;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;PFMaker, the Advanced Interactive Video Tool;1/05/2015;31/08/2015;;"People are accessing, consuming and sharing content in more varied ways than ever, and marketers have scores of new opportunities to understand, reach, and engage with consumers. Up to this point, companies are spending 171 billion dollar in digital advertising per year. However, online advertising is intrusive, boring and even bothering. Almost a 92% of people give up Pre-Roll ads with the option Skip-Ad, when this option is not shown, 15% of people close the entire video to avoid the ad. In-Video Ads doesnt work better, 15% of viewers close the image shown at bottom, barely a 3% click on that kind of ad.

In order to overcome these problems we have tested in a relevant environment a new interactive video format that increases user engagement. In spite of this, producing interactive video contents is still expensive and barely unprofitable, thus increasing the total production costs up to a 50%.

The purpose of this innovation project is to develop a new tool and interactivity market ecosystem to create fully advanced interactive experiences in a cost effective and profitable way. This tool will be named PFMaker and will reduce the time of production of an interactive video by a 67% and its development costs by up to 81%. This tool will allow the quick creation of interactive videos with advanced user interactions such as 3D Graphics and Augmented Reality.

At this stage we have conducted a pilot project to verify the interest in a relevant environment, but a deeper feasibility study is needed in order to minimize the investment risks. Our feasibility study will consist of an international market and user research and an IPR analysis.

PlayFilm is a young tech startup, with greatly experienced executive team, that has already received the interest of big companies and support of the accelerators programs. PlayFilm aims to shake the entertainment industry through a new advertising format which not only does not interrupt the user experience, but also adds value";71429;50000;H2020-SMEINST-1-2014;SME-1;PLAYFILM SL;ES;;; 196498;673354;ASWD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Advanced Space Weather Detector;1/05/2015;31/10/2015;;"The objective of the project is to develop an Advanced low-cost High Resolution Cosmic Ray Detector: State-of-the-art particle-accelerator-derived TRL6-proven technology innovatively applied to Space Weather.

The short-term business concept is the use of such detectors for advanced early detection of Geomagnetic Storms with unprecedented accuracy and local data, which has an immense European/Global commercial interest due to the growing problems generated by Space Weather events, the fragility of our infrastructures and the broad range of industries which are severely affected by them.

This global-impact project bases its commercial opportunity in the well-known vast cost saving potential of accurate early warnings for key industrial sectors such as Energy, Telecommunications, GNSS, Transportation or Insurance.

The detector will have unparalleled resolution and low cost. This will make it possible to monitor critical infrastructures on-site. It will also allow to create a low-cost, dense, high resolution European/Global network of such detectors. Both applications are absolute novelties.

The detector will be affordable, standalone, modular and scalable, which will make it perfect also as lab equipment. Its broad range of scientific applications and low cost will mean that many small research departments will benefit from it, maximizing the international impact of the project. This can also boost the research in areas such as Space Weather, restricted until now to big experiments.

Universities, international experiments, Astrophysics, Space Weather, Climate and other research institutes will comprise the end-users together with the main customers: the private sector.

In this phase 1, a comprehensive study of all the resources needed for phase 2 will be carried out, this will include business plan, marketing plan including all potential stakeholders and financial/economic study, taking into account H2020 funding as well as the companys own resources.";71429;50000;H2020-SMEINST-1-2014;SME-1;HIDRONAV TECHNOLOGIES S.L.;ES;;; 196616;643269;SME CoachLT;SIGNED;H2020-EU.2.3.;INNOSUP;H2020;Establishing services enhancing the innovation management capacity of SME's in the Lithuanian Enterprise Europe Network consortia;1/07/2014;31/12/2014;;"The overall aim of SME CoachLT is to increase effectiveness and efficiency of investment in R&D and Innovation by enhancing innovation management capacity of Lithuanian SMEs -beneficiaries of the new dedicated SME instrument under Horizon 2020, and SMEs with significant innovation activities and a high potential for internationalisation.
Specifically, the project will support SMEs - beneficiaries of the SME instrument- in identifying project-specific barriers and weaknesses and gaps in their innovation capacities that hinder realization of growth opportunities, and pointing to suitable coaches to address the identified weaknesses. The second specific objective is supporting SMEs with significant innovation activities and a high potential internationalization in enhancing their innovation management capacities.
The Key Account Manager will support SMEs SME Instrument beneficiaries in identifying critical issues and gaps with regards to their innovation idea and guide them to relevant lead coach who will support the company throughout their innovation journey. The Key account Manager will use a holistic and dynamic business innovation model, supported by Business Innovation Roadmap Tool, available under Creative Commons License from smE-MPOWER network. Based on the systematic assessment logic embedded in the tool, the Key Account Manager will guide the company through a transparent and easy-to-use self-assessment process.
When supporting companies having innovation and internationalization potential, but not part of SME instrument, we will use IMP3rove Academys diagnostic tool which measures the performance of the companys innovation management system. However taking into account the SME context, we intend to use action- based (and case-driven) learning approach to addressing identified gaps in the innovation system. smE-MPOWER tools can support the coaching process.";11812,5;9450;H2020-Adhoc-2014-20;CSA;VIESOJI ISTAIGA LIETUVOS INOVACIJU CENTRAS;LT;;; 196555;674203;CAIN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Analysis of multimedia contents published on social networks, using a community of people willing to perform micro-tasks on their mobile devices. Application to marketing and branding;1/05/2015;29/02/2016;;Social networks contain valuable information for businesses. Companies able to understand what is said on social networks will have a significant competitive advantage. However, information extraction is not simple because it is not structured and because the volumes are very large. So far, algorithms have been developed to analyze texts inaccurately. But also the language of social networking is based on images and videos. Both formats growing faster than the text. The algorithms are far from understanding the meaning of multimedia contents, or extract useful information from them. Our solution assumes that today, and for a long time, this work can only be done by the human mind. Therefore we have the technology and methodology appropriate to do so. The analysis is performed by distributing micro-tasks to the mobile devices of a community of human solvers. The specific software creates micro-tasks, distributes it and reports the results. The micro-tasks are presented as games or activities that are resolved in less than 1 minute. The solvers are anonymous volunteers who perform the micro-tasks in exchange for an amount of money that is donated to the NGO of their choice. To participate, the solvers must download an application on their mobile devices. Virtually any business is a potential client of this solution, but especially those with brands targeted directly to consumers, with great presence in social networks. The scope of our project is first European and then global. The software and methodology have already been tested successfully in image analysis projects conducted by The Harvard University and the University of Barcelona. However, before marketing it is necessary to work on the value proposition meeting the information needs of businesses and testing the solution in a business environment. We also need to study the motivations of solvers to develop plans for growth of this community. Moreover the BP must be completed. These are objectives of Phase 1.;71429;50000;H2020-SMEINST-1-2014;SME-1;GNOTO MARKETING AND SALES SL;ES;;; 196617;643349;EENHessenInnovation;SIGNED;H2020-EU.2.3.;INNOSUP;H2020;Establishing services enhancing innovation management capacity of SMEs in the Enterprise Europe Network: Hessen;1/07/2014;31/12/2014;;"Hessen Trade & Invest GmbH (HTAI), representing the EEN Hessen consortium busyhessen, will implement the action Establishing services enhancing the innovation management capacity of SMEs in the Enterprise Europe Network calculating with a minimum number of thirteen seven-day-packages with the objective to support innovative SMEs with a high potential for growth and internationalisation.
Thus, interested beneficiaries of the SME Instrument will be supported with key account management (KAM). Other enterprises, assessed as suitable by EEN Hessen, will be supported in the separate process of Enhancing Innnovation Management Capacity (EIMC). HTAI will use the Innovation Health Check by Enterprise Ireland as a CEN/TS 16555-1 tool to assess the innovation management capacity of Hessian clients for both services offered.
Five EEN Hessen innovation experts, all senior EEN staff experienced in innovation management, are foreseen for this action.";42063,75;33651;H2020-Adhoc-2014-20;CSA;HESSEN TRADE & INVEST GMBH;DE;;; 196648;662816;KERS-P;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Development of a universal kit to be installed on existing and new High Tonnage Hot ForgingPresses, for a potential strong reduction of energy consumption of the European installed fleet.;1/02/2015;31/07/2015;;"FARINA PRESSE, 80 years old Italian SME specialized in High Tonnage Hot Forging Presses (HTHFP: > 25.000 kN) with a solid R&D tradition and a fame of excellence in hot forging sector, aims at developing a UNIVERSAL KIT, suitable to be installed on the most different types of existing HTHFPs, capable to reduce up to 30% their electric energy consumption and increase up to 33% their productivity, so that to address the potential of the European working HTHFPs' fleet and obtain an important energy consumption reduction at system level.
The European forging industry, an highly energy intensive sector, is steadly forced to reduce production costs and increase production volumes. The project will allow to meet the forging industry needs and its application on the European market will obtain significant energy saving on European energy networks. We estimate our kit will allow to save about 210 MWh/year for an average HTHFP, actually dissipated as unproductive heat: if extended to the European HTHFP fleet, it means a potential saving of 420 GWh/year, equivalent to a reduction of 210.000 tons CO2 emission per year.";71429;50000;H2020-SMEINST-1-2014;SME-1;FARINA PRESSE SRL;IT;;; 196633;646112;NMP TeAm 3;SIGNED;"H2020-EU.2.1.3.;H2020-EU.2.1.5.;H2020-EU.2.1.2.";NMP-39-2014;H2020;Improving the services of the NMP NCP Network through Transnational Activities;1/01/2015;31/12/2016;;"NMP TeAm 3 is the continuation of the successful EU projects NMP TeAm 1&2. It aims to facilitate transnational cooperation between NCPs within the Industrial leadership Part with a view to identifying and sharing good practices and raising the general standard of support by the NMP NCPs to programme applicants as described in the work programme. NMP TeAm 3 will achieve a consistent, improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls, lowering the entry barriers for newcomers, and raising the average quality of proposals submitted.

NNP TeAm 3:

- Will create the mechanisms and tools for capacity building of NCPs' skills that will ensure the NCP Network's high and consistent level of services to clients. These will include 10 training events, 10 staff exchanges and twinning schemes and self -assessment through benchmarking.
- Will provide the necessary tools to all NMP NCPs so that they can assist their clients to increase their success rate in H2020 and lower the barriers for participation for new applicants. These will include the improvement of the Partner Search Facility of NMP TeAm 1&2, organisation of 4 brokerage events at large EU presidency conferences and 6 virtual information seminars for clients on H2020.

- Will improve the outreach of the NMP NCP Network and maximise the impact of its activities, services and results to a wide audience of clients and stakeholders. This will be achieved through the continuation of the NMP TeAm website, which is already a focal point of the community of NCPs and programme applicants, continuous dissemination of information through social media and participation of NCPs at large NMP related events to provides assistance and services. NMP TeAm 3 will also maintain and create new links with stakeholders like the Enterprise Europe Network, European Technology Platforms and other NCP Networks to reach as many as possible H2020 applicants.";599135,12;599135,12;H2020-NMP-CSA-2014;CSA;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;"FORSCHUNGSZENTRUM JULICH GMBH;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;The Technology Strategy Board;MATIMOP - THE ISRAELI CENTER FOR R&D;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"DE;FR;PL;UK;IL;IT;PT"; 196511;673533;DryEye;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Validation of a Novel Diagnostic Biomarker for Dry Eye Syndrome based in nucleotides detection;1/06/2015;31/01/2016;;"Scientists of our company invented a method for diagnosing and monitoring the effectiveness of dry-eye syndrome treatment. The invention is related to a method for diagnosing the Dry Eye syndrome in patients and monitoring the effectiveness of the treatment, by measuring the concentration of a molecule called diadenosine tetraphosphate dinucleotide (Ap4A). Ap4A is an intracellular signal molecule that is produced due to harsh environmental factors. According to our studies published since 2002, Ap4A is released from the corneal epithelium, stimulating tear production and is a physiological modulator of tear secretion. Most importantly we discovered that levels of Ap4A are up to 5 times above normal levels in patients with Dry Eye compared to patients with normal lacrimation. This increase is even higher in Dry Eye individuals with low tear production. In these cases the Ap4A is increased over 100 fold. Following this discovery we patented a method to measure the concentrations of Ap4A of tear samples from patients in order to determine its presence, which is abnormally high in the case of Dry Eye syndrome. According to this method it is possible objectively to confirm or to discount the presence of this pathology. The diagnostic method of this invention comprises: detection by means of the high-pressure liquid chromatography (HPLC) technique of the Ap4A molecule, for the purposes of the calculation of which use will be made of a standard sample of Ap4A of commercial origin and of known concentration; and the use of a luminometric method for the detection and quantification of the Ap4A dinucleotide by means of the use of luciferin luciferase. We already effectively tested the method in vitro and in vivo on Dry Eye animal models. Recently we made a successful first stage trial in a small number of patients. Our future actions include the collaboration with industry partners, expert on biomarkers, in order to create a small detection kit.";71429;50000;H2020-SMEINST-1-2014;SME-1;OCUPHARM DIAGNOSTICS SL;ES;;; 196595;673763;PolyHalter;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Development of Polymer Halter for Oil Filters;1/06/2015;30/11/2016;;"PolyHalter project is a direct response to demands for innovative, cost-effective solution which would allow car manufacturers to install lighter, more efficient and lower-priced engine parts (with smaller number of assembly parts). Development of polymer oil filter halter represents significant technological advance in field of engine parts, giving Polycom access to still-developing niche market and significant advantage over competitors.

While aluminium has been gold standard in production of oil filter halters for over 70 years, new polymer oil filter halter will enable the combination of minimum noise level, maximum mass savings and maximum price reduction at the level of which hasnt been achieved so far. Final product will be positioned as a better, cheaper and more eco-friendly alternative to aluminium oil filter halters which wont need high volume logistics and will be capable of multifunctioning. Number of components within the product will decrease, as well as possibilities of errors.

In order to bring the currently developed prototype of polymer oil filter halter from current TRL 6 to industrial and market readiness, key innovation and commercialisation activities still need to be implemented.

Additionally, new process (and injection moulding tools) for injection moulding of polymer filter halters will be further optimized to allow manufacture of up to 20 different types of polymer halters in 5 years after completion of the project, for various industries (automotive industry, compressor manufacturing, electro industry, home appliances industry, aircraft industry and similar).

Proposed innovation business project is in line with the work programme topic IT-1-2014: Small business innovation research for Transport.";724550;507185;H2020-SMEINST-2-2014;SME-2;POLYCOM PREDELAVA PLASTICNIH MAS IN ORODJARSTVO SKOFJA LOKA D.O.O.;SI;;; 196629;645588;Q-Tales;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;A Collaboration Ecosystem enabling EU Creative SMEs to exchange multi-media content and create multi-plot, interactive Apps for Children, curated according to Reader ability and educational value.;1/01/2015;30/06/2016;;"Q-Tales is a Collaboration Ecosystem, specifically designed to serve the needs of the European Children e-book industry, where European Creative SMEs, Experts and Parents, co-create new or transform existing Children Literature into high quality e-books & Apps using innovative ICT solutions provided by European ICT SMEs along with a Curation Framework provided by European Academic experts in the field of Pedagogy, Children Psychology and evolutionary Psychology. The specific objectives of the project are summarized below:
Objective 1: Build the Q-Tales Collaboration Platform and respective ecosystem, including Gamification Aspects, where European self-publishers, authors, illustrators, voice actors, animators and other related SMEs & professionals will find & submit industry news, communicate, offer & receive services and collaborate.
Objective 2: Develop the Q-Tales Authoring Tool, featuring an easy-to-use interface with powerful and sophisticated authoring features which will be used to create the Q-Tales e-books and apps, incorporating the Q-Tales Ontology and utilizing gamification techniques.
Objective 3: Launch the Q-Tales Store where the authored e-books and apps will be offered worldwide.
Objective 4: Define the Technical and Pedagogical Q-Tales Curation Frameworks, in order to ensure that every single item sold is, technically perfect and better connected with current academic developments in the fields of child / evolutionary psychology while offering a scent of Europeanness, whilst incorporating nation- and country-specific literacy cultural and linguistic elements.
Objective 5: Develop a new breed of in-app analytics services.
Objective 6: Identify & Connect with established European Children Literature Content Providers and Sources.
Objective 7: Establish Q-Tales as a Brand Name with European Publishing Industry.
Objective 8: Introduce the Q-Tales Awards as an annual creativity competition.";1273526,6;986193;H2020-ICT-2014-1;IA;THEOFANIS ALEXANDRIDIS KAI SIA EE;EL;"MILOPOULOS GRIGORIOS;GAMIFICO LIMITED;FORMA CAMERA - AZIENDA SPECIALE DELLA CAMERA DI COMMERCIO, INDUSTRIA,ARTIGIANATO E AGRICOLTURA DI ROMA PER LA FORMAZIONE IMPRENDITORIALE;ORTELIO LTD;REAL GROUP (UK) LIMITED;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IZBA PRZEMYSLOWO - HANDLOWA W KRAKOWIE;PUBLISTO DIGITAL APPLICATIONS EPE";"EL;UK;IT;IE;PL"; 196578;638426;NoisyAgeing;SIGNED;H2020-EU.1.1.;ERC-StG-2014;H2020;Beyond genotype to phenotype: how ancestor lifestyle impacts on lifespan variation in descendants;1/06/2015;31/05/2020;;There are many examples in nature where inter-individual variability in life-history traits is exploited as an adaptive strategy. I and others have shown that inter-individual variability in the longevity pathways and in particular, in stress response genes- has consequences for genetic/environmental phenotypic robustness as well as for lifespan in Caenorhabditis elegans. My main interest is to uncover the causes that explain inter-individual variability in lifespan. The variability across individuals must include an important non-genetic component because the laboratory strains of this nematode are genetically homogeneous. I propose that lifespan variation is a by-product of non-genetic sources of variability in the pathways that control longevity. Strikingly, inter-individual differences in stress responses are transgenerationally transmitted. Transgenerational memory is an adaptive strategy that informs the next generation about the likely environmental cues that will be encountered, and sets patterns of gene expression by the incomplete erasure of chromatin marks in the germline. I hypothesise that transgenerational epigenome inheritance introduces transcriptional variability for genes that influence lifespan. Also, I propose that the probabilistic nature of lifespan is caused by inter-individual differences in the inheritance of longevity genes that set the rate of ageing from early development. Understanding the basis of lifespan variability is crucial for personalised medicine, where not the average population but rather the individual is centre stage. It is equally crucial for the identification of new factors that may have been missed by the analysis of population averages that can have an impact for human ageing and health. More generally, I propose the inter-individual variability in the vertical transmission of transcriptional states as a unifying framework underlying a large class of adaptive phenotypes that vary among individuals.;1499978;1499978;ERC-2014-STG;ERC-STG;THE BABRAHAM INSTITUTE;UK;;; 196620;643889;eStandards;SIGNED;H2020-EU.3.1.;PHC-34-2014;H2020;eHealth Standards and Profiles in Action for Europe and Beyond;1/05/2015;30/04/2017;;"The eStandards CSA is proposed by HL7, CEN TC251, & IHE, leading Standards Organizations (SDOs), and is supported by the eHealth Network, ISO TC215, GS1, IHTSDO, IEEE11073, and IMIA to advance eHealth interoperability and global alignment of standards with seven objectives:
1. Join up with Stakeholders in Europe and globally to build consensus on eHealth standards, accelerate knowledge-sharing, and promote wide adoption of standards.
2. Deliver an evidence-based Roadmap for alignment, iterative consolidation, and broad acceptance of eStandards that is endorsed by SDOs, the eHealth Network, the providers, and the Industry.
3. Contribute to the eHealth Interoperability Framework use cases focusing on clinical content modelling for different paradigms and embed a Quality Management System for interoperability testing & certification of eHealth systems.
4. Collect evidence and provide guidance on the coexistence of competing or overlapping standards in large-scale eHealth deployment nationally and cross-border.
5. Participate in EU/US MoU roadmap actions as the international patient summaries standard.
6. Explore socio-economic aspects of eHealth interoperability, revisiting the language for user-vendor interaction that embodies co-making in trust, collaboration and long-term engagement.
7. Align across PHC-34 to nurture innovation, sustainability & growth under CEF and beyond contributing to Key actions of the Digital Agenda 2020.
The proposals ambition is to strengthen Europes voice and impact, while reinforcing the bridges established with the EU Patient Summary guideline across the Atlantic in Trillium Bridge and among MS with epSOS, eSENS, Antilope, and EXPAND. The eStandards Roadmap and associated evidence base, a white paper on the need for formal standards, and two guidelines addressing how to work with: (a) clinical content in profiles and (b) competing standards in large-scale eHealth deployments will be pragmatic steps toward alignment and convergence.";999769;999769;H2020-PHC-2014-single-stage;CSA;RESEARCH IN ADVANCED MEDICAL INFORMATION AND TELEMATICS vzw;BE;"COMITE EUROPEEN DE COORDINATION DES INDUSTRIES RADIOLOGIQUES ELECTROMEDICALES ET D INFORMATIQUE DE SANTE AISBL;HL7 INTERNATIONAL FONDATION;STICHTING NATIONAAL ICT INSTITUUT IN DE ZORG;STICHTING NEDERLANDS NORMALISATIE - INSTITUUT;INTEGRATING THE HEALTHCARE ENTERPRISE-EUROPE AISBL;FEDERATION EUROPEENNE DES HOPITAUX ET DES SOINS DE SANTE;EUROPEAN INSTITUTE FOR HEALTH RECORDS;REGIONE LOMBARDIA;OFFIS EV;MEDIQ AS;SPMS - SERVICOS PARTILHADOS DO MINISTERIO DA SAUDE EPE";"BE;NL;FR;IT;DE;DK;PT"; 196649;663113;DRESSFORMER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Virtual 3D fitting room for online shopping;1/04/2015;31/07/2015;;"DRESSFORMER is a B2B/B2C platform technology allowing the user to virtually try on clothing pre-purchase and receive personal or professional feedback. The virtual fitting rooms are based on photorealistic 3D avatar & 3D models created from 2 photos of the cloth providing accuracy within 1 cm precision. Dressformer's fitting technology increases profitability of retailers by addressing fitting & likability simultaneously, hence reducing returns - better and faster than competing approaches. The current method for trying and visualizing clothes on online stores is highly ineffective as it only allows users the possibility to view clothes in a 2D picture or on a mannequin, resulting in extra costs due to returns from poor fitting purchases. Returns constitute more than 40% of items bought online. Out of them 20% of returns are due to poor fit. 80% of the online customers will not buy clothing online again. Dressformer proposes a try on button integrated with any online store. The function is based on a patented innovative technology that automatically generates a 3D model of a garment.
Once pressed the online user is redirected to a pop-up window with 3D image of a dress worn by a 3D avatar that creates a virtual replica of the online buyers body. Dressformer generates simulations of clothing on the human form, including a realistic 3D rendering that displays imperfection and a heat map noting where different sizes will fit tightly on the body. The users will input their hip, waist and chest measurements into the online fitting application. Once the measurements are inserted the virtual avatar morphs into the natural shape and curves of the individual users body while taking materials and elasticity into consideration. This will allow online retail consumers to try on various garments and give them the ability to clearly and accurately distinguish between materials, textures, shapes, folds and embellishments.";71429;50000;H2020-SMEINST-1-2014;SME-1;DRESSFORMER LTD;UK;"WARDROBA SRL;CAMICERIA GIOVANNI TACCALITI SRL";IT; 196540;673885;CARDISENSE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Innovative sensor for continuous monitoring of heart function during and after surgery;1/05/2015;31/10/2015;;"Postoperative complications for high-risk patients going through open heart surgeries are a major cause of morbidity and mortality and is responsible for a very large proportion of the overall health and socioeconomic burden of illness. In Switzerland for example, it is estimated the costs increase by 57 % post operation for high-risk patients with pre-operative complexities. The total cost of postoperative complications in Europe alone amounts to approximately 6 billion annually.
CARDIACCS proposes a novel invasive medical device CARDISENSE (CARDIAC SENSOR) which assists continuous monitoring and diagnosis of patients going through open heart surgeries. Our initial studies indicate that CARDISENSE is well suited to make an immediate impact on the diagnostic accuracy in perioperative myocardial ischemia.
CARDISENSE belongs to the cardiac monitoring and diagnostic devices market, which is forecasted to reach at US$12.3 billion by 2015 at a CAGR of 11%. Such devices are used to detect and feedback abnormal episodes of electrical functioning of the heart. None of these devices is specific for monitoring and diagnosis of perioperative heart surgery complications. CARDISENSE is a niche in this market and can be used in all cardiac surgical procedures for perioperative diagnosis and monitoring, becoming a new gold standard.
CARDIACCS IP strategy is very strong. The background knowledge has already been protected and is in the ownership of CARDIACCS.
CARDISENSE is an opportunity for CARDIACCS to establish a niche in the perioperative cardiac surgery diagnostic and monitoring market and maintain the European competitiveness. CARDISENSE will positively impact clinicians and patient and support the sustainability of healthcare system through early stage diagnose and treatment of perioperative cardiac surgery complications.";71429;50000;H2020-SMEINST-1-2014;SME-1;CARDIACCS AS;NO;;; 196514;673562;RETOXY;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of retinal oximetry as a biomarker;1/05/2015;31/10/2015;;"Disturbance in oxygenation of the retina of the eye is believed to be involved in many sight-threatening diseases, such as diabetic retinopathy, glaucoma and age-related macular degeneration. Oxymap ehf (SME) has developed an oximeter to measure retinal oxygenation. The oximeter is already used by over 20 research groups and the results of small-scale studies indicate that the oximeter can measure disturbed oxygenation in various common and serious eye diseases.

The Oxymap oximeter is currently only useable for research and the aim of the phase 1 and 2 projects is to validate oximetry for clinical use. This will allow earlier intervention and better monitoring of disease progress, benefiting individual patients. Due to the high prevalence and severity of the diseases, societal and economic gains are also considerable. Moving retinal oximetry from being a research tool only to being a validated clinical biomarker will also create a much larger market for Oxymap.

The phase 1 project will yield a feasibility report, including a business plan. The project will lay the foundation for later uptake of retinal oximetry in clinical practise and the concurrent successful commercialisation.";71429;50000;H2020-SMEINST-1-2014;SME-1;OXYMAP EHF;IS;;; 196483;672936;Smartphone-ANCIH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Smartphone A new concept in hearing: an interactive real-time embedded audio solution that offers a significant/disruptive change in hearing technology and market.;1/05/2015;31/10/2015;;"Effective hearing ability influences individuals overall quality of life, particularly in situations (such as in work-places, meetings, classrooms, social gatherings, or using audio devices) where unwanted noise constantly tests and challenges our audio processing capabilities. In these situations all existing hearing aids share a common underlying concept flaw due to the fixed position of the microphone and the lack of user interactivity. Coupled with inelegant and unfashionable designs, this causes many hearing-impaired individuals to opt out of using hearing aids and withdraw from these social/work group situations.
The Smartphone platform is an excellent example of technology with the potential to enhance the audio experience of individuals with hearing loss whilst blurring the distinction between hearing and consumer technologies. Combined with our innovative audio separation techniques and pioneering wireless technology, it removes the social stigma and provides a significant step change in hearing market accessibility, dispensing and affordability allowing everyone to live fuller normal lives. Auriplexs Smartphone A new concept in hearing is innovative not only in technology but also in the market reach strategy: the solution would be aimed at a new market that is distinctly different from current hearing aid offerings but at the same time will be familiar as a consumer product and a logical next step with most technology users not only in the hard-of-hearing but also in the hearing world. A disruptive innovation everyone will hear about!";71429;50000;H2020-SMEINST-1-2014;SME-1;AURIPLEX LIMITED;UK;;; 196605;637245;EFFECTIVE;SIGNED;H2020-EU.2.1.5.1.;FoF-07-2014;H2020;Exploiting Factory of the Future projects through Enhanced Clustering towards Technology Transfer, Innovation and Value creation for European industry.;1/01/2015;31/12/2016;;"The EFFECTIVE project foresees the following objectives:
analyse business trends and market prospects, and perform reviews & workshops to get a consistent set of information for clustering and exploitation of FoF projects activities and results;
develop and industrial exploitation framework for the promotion and transfer of FoF projects activities and results, and structure networks & alliances to achieve such objectives;
active clustering of FoF activities and results based the identification of six major technological FoF areas, addressing also potential sectors and applications for exploitation and transfer of the considered clusters of technologies;
analyse best practices and case studies of FoF results clustering, exploitation and transfer through 4 relevant regional case studies in low-, medium- and high-technology intensive sectors, by means of the involvement of innovation actors of the considered regions;
set up instruments for adequate monitoring of FoF activities clustering and exploitation during the project life-time and beyond, to ensure an effective implementation at programme level;
identification of future FoF priorities within the technological areas of the addressed clusters and roadmapping of needed further research and innovation actions;
promote and disseminate the EFFECTIVE project results and tools to a large community of European actors through qualified networks and associations (such as EFFRA, Enterprise Europe Network, EBN and EURADA);
involve international experts and create strategic links with international initiatives to support the full achievement of EFFECTIVE objectives on global scale.";396625;299661;H2020-FoF-2014;CSA;SYNESIS-SOCIETA CONSORTILE A RESPONSABILITA LIMITATA;IT;"STEINBEIS 2I GMBH;STEINBEIS INNOVATION GGMBH;INSTITUTO VALENCIANO DE LA COMPETITIVIDAD EMPRESARIAL;BRAINPORT DEVELOPMENT NV";"DE;ES;NL"; 196577;637533;BIFLOW;SIGNED;H2020-EU.1.1.;ERC-StG-2014;H2020;Bilingualism in Florentine and Tuscan Works (ca. 1260 - ca. 1416);1/10/2015;30/09/2020;;"This project will undertake the first systematic investigation of the various literary documents that circulated simultaneously in more than one language in Tuscany, and especially Florence, between the mid-13th Century and the beginning of 15th Century.
During that period, Florence was both a prominent literary centre in the vernacular, and home to a renewal of classical Latin eloquence. While both fields are well studied, their interaction remains largely unexplored. This research, at the convergence of several disciplines (literature, philology, linguistics and medieval history), has a strong pioneering character. It aims at changing the perception of medieval Italian culture and interpretation of the break between medieval Culture and Humanism.
For this reason, the project will develop research in varying degrees of depth. First, it will provide the first catalogue of bilingual texts and manuscripts of medieval Tuscany. Organized as a database, this tool of analysis will stir innovative research in this field, some of which will be immediately promoted during the project.
Secondly, two case studies, considered as important and methodologically exemplary, will be researched in detail, through the publication of two important set of texts, of secular and religious nature: 1. The vernacular translation of the Latin Epistles of Dante Alighieri; 2. A collection of polemical, historiographical, devotional and prophetical documents produced by the Tuscan dissident Franciscans in last decades of the 14th Century.
Finally, the entire team, led by the PI, will be involved in the preparation of a synthesis volume on Tuscan culture in the fourteenth century viewed through bilingualism, entitled Cartography of bilingual culture in Fourteenth-Century Tuscany. From this general map of the Italian culture of the time, no literary genre nor field (be it religious or lay) shall be excluded.";1480625;1480625;ERC-2014-STG;ERC-STG;UNIVERSITA CA' FOSCARI VENEZIA;IT;ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES;FR; 196615;642928;SAFARI;SIGNED;H2020-EU.2.1.1.;EUJ-2-2014;H2020;Scalable And Flexible optical Architecture for Reconfigurable Infrastructure;1/10/2014;30/09/2017;;"Highly scalable & flexible optical transport networks are urgently required in order to meet the demands for unrelenting exponential data traffic growth (estimated at 40 - 50 % per annum). The number and diversity of bandwidth intensive applications and services is rapidly increasing, leading to new demands on transport networks. The present optical transport networks based on conventional fibres, however, are facing fundamental limits in capacity/throughput and are lacking in terms of network flexibility and control. The Scalable And Flexible optical Architecture for Reconfigurable Infrastructure (SAFARI) project aims at developing programmable optical hardware, and Space-Division Multiplexing (SDM)-based optical component technologies capable of realising highly scalable & flexible optical transport networks for the long term future. The high level objectives of the SAFARI project are to:
- Develop programmable optical hardware allowing novel multi-flow transport functions which is scalable to at least 400 Gbps/channel transport, and implement the critical interworking capability required between the software-defined network (SDN) layer and the physical layer.
- Develop SDM-based optical transport technology based on super-dense, high-count multicore fibres (MCFs) and multicore erbium-doped optical fibre amplifiers (MC-EDFAs). The technology should be capable of supporting more than 30 cores per-fibre.
- Undertake system experiments on scalable & flexible optical transport networks based on the newly developed SDN-controlled interworking capability and capacity-scalable hardware, showcasing the unique functionality and capabilities made possible. Specific attention will be focussed on demonstrating that the SDN-controlled programmability developed is compatible with both existing single-mode-fibre transmission systems and future SDM-based systems, allowing for a graceful upgrade scenario with current systems.";1485818,75;1485818,75;H2020-EUJ-2014;RIA;DANMARKS TEKNISKE UNIVERSITET;DK;"UNIVERSITY OF SOUTHAMPTON;CORIANT R&D GMBH";"UK;DE"; 196647;662782;KDRP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;KiWi Power Limiteds Revolutionary, Low Cost, Demand Response Platform (KDRP);1/03/2015;30/06/2015;;"CHALLENGE: Demand response (DR) is central to the successful evolution of a new low carbon electricity system in order to deliver grid flexibility & stability, however it is progressing slowly in the EU due to technological barriers which prevent widespread uptake: high in cost hardware (4.000 - 6.000); not specifically designed for DR ? lack critical functionality (e.g. wireless communication, integration of renewables); & not sufficiently open for wider industry participation.

PROPOSED SOLUTION: To address the need for innovations that overcome principal barriers to DR, this project seeks to advance KPLs Energy Management Platform, KEMP, from a prototype demonstrated in a relevant environment (TRL6) to complete & qualified commercial prototype (TRL8). KEMP is a low cost, automated ancillary services platform which consists of: [1] Unique hardware: multi-asset control; first platform to integrate renewable assets; wireless communication between assets ? reduced installation cost; & sec. by sec. meter readings requirement for Frequency Response programmes. [2] Innovative software: cloud based for greater scalability; flexibility & remote monitoring, forecasting model - for integration of renewables; & optimisation engine - to max. revenues.

END USERS: [1] Initial target = large scale commercial & industrial (C&I) orgs with high MW capacity (>1MW) e.g. financial, telecoms, hospitals, hotels etc. Asset types: DRUPS systems & HVAC. [2] Secondary target = SMEs with low MW capacity (50kW< capacity < 1MW) incl. Water Pump Stations, Small Data Centres, Retail Stores. Asset types: Variable Speed Motors, HVAC, UPS systems etc.

STUDY OBJECTIVES: tech validation, market analysis, economic & business assessment, operational capacity analysis. Activities will be delivered within a 4 month period, & result in a comprehensive feasibility report detailing the next steps towards development & commercialisation, forming the basis of the SMEI Phase II Business Plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;KIWI POWER LTD;UK;;; 196639;652683;ProBIO;SIGNED;H2020-EU.3.2.;ISIB-08b-2014;H2020;Professional support to the uptake of bioeconomy RD results towards market, further research and policy for a more competitive European bioeconomy;1/03/2015;31/08/2017;;"ProBIO is a support action directly benefiting consortia of FP7 KBBE and H2020 bioeconomy. The overall objective is two-fold:
1. To support the flow of knowledge-based bioeconomy project results from research to market, as well as back to R&I.
2. To foster the networking and knowledge exchange between different European bioeconomy initiatives under H2020 and FP7 and the most important players in the field thus raising awareness towards policy makers and engaging the general public.

To achieve its objectives, ProBIO screens all 411 KBBE projects for results, describes them in interaction with the KBBE consortia, and finally classifies each result according to its nature. The results will be of different technological maturity level: some will be mature for direct market introduction, others need further development to reach a higher TRL, and some are not technological results, but knowledge and instruments of relevance to policy makers.
The ProBIO experts take this diverse nature and maturity level of research results into account and support each type of result with dedicated professional coaching and tools with a view to:
a. Accelerating market entry through business coaching of the most promising R&D results
b. Facilitating the flow of knowledge into new R&I projects in order to reach a higher TRL level
c. Feeding policy-relevant results into the political process to inform policy making

ProBIO also foresees a range of events and communication activities supporting knowledge exchange and linkage of different actors along the bioeconomy value chains and making use of synergies through networking.

The multi-disciplinary team of the ProBIO consortium is built around highly specialised green innovation consultancies and a European expert group who together have an outstanding track record in promoting the uptake of results from public research. Additional thematic expertise is ensured by two technical centres, and communication is in professional hands, too.";1588158,75;1588158,75;H2020-ISIB-2014-1;CSA;AZIENDA SPECIALE INNOVHUB - STAZIONI SPERIMENTALI PER L'INDUSTRIA;IT;"Greenovate! Europe;I.CON. INNOVATION GMBH;TECHNOFI SA;ZABALA INNOVATION CONSULTING, S.A.;INVESTORNET-GATE2GROWTH APS;RISE RESEARCH INSTITUTES OF SWEDEN AB;ICONS SRL";"BE;DE;FR;ES;DK;SE;IT"; 196542;673930;INE IAPS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Intelligent active protection system for motorcyclists: saving lives through optimum use of latest advances in sensor technologies, wireless communication, Smartphone platforms, real-time analysis.;1/05/2015;31/10/2015;;"The risk of fatalities or sustaining serious injuries in motorcycling accidents is poorly addressed by the existing body protection devices available to that community. They lack in reactivity characteristics and offer limited protection to the most affected parts of the body.
Combining advances in sensor technologies, wireless communication and Smartphone platforms in particular, In&motion is set to revolutionise the market with their intelligent active protection system. With an ultra-high energy absorption capacity and a much wider protection area, their all-electronic system further differentiates itself from competitor products with its auto-learning capability: the more it is used the better it performs. With a business-to-business approach, In&motion joins forces with key European motorcycling garments manufacturers who recognise the need for their specialised clothes to become intelligent and highly protective. The technology is therefore fully integrated into the clothing, making it very convenient for the user. To further simplify the users experience, In&motions other innovation lies in the ability for the user to reactivate the device after deployment, thanks to easy-to-handle consumable parts. This provides a significant step change in accessibility, dispensing and affordability for the user.
With European motoring legislations set to further impact the market potential for body-protection devices, In&motions solution is bound to be truly disruptive.
The technology has already been highly acclaimed by ski athletes and the International Ski Federation, and In&motion have high ambitions to see that technology also used in other areas such as drone protection, seniors health and well-being, and work at height.";71429;50000;H2020-SMEINST-1-2014;SME-1;IN&MOTION;FR;;; 196496;673202;EeC WITUR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Efficient energy cleaning robotic platform for wind turbines (EeC WITUR);1/05/2015;31/10/2015;;"The purpose of the project is the large-scale commercialization of an integral both preventive and predictive maintenance service by means of cleaning and inspection actions of wind turbines for the increase of its energy efficiency, based on a monitored robotic platform.
This robotic platform is innovative in the wind market due to its performance in connection to two preventive maintenance operations which are currently carried out manually, thus resulting in the corresponding cost, efficiency and hazard issues associated to them:
Cleaning service: the platform carries a water cannon with two degrees of freedom capable of injecting both hot water and soap at high pressure all over the surface of the tower, blades and nacelle, thus performing the cleaning tasks.
Inspection service: the robotic platform is capable of carrying adjustable high resolution cameras, and thermographic cameras, thereby collecting data, generating graphic reports, images, and high resolution videos. In the management and maintenance of towers, it is essential and really useful to conduct a close-range and detailed control of blades, which will allow for fast and concrete repairs to be carried out, thereby immediately increasing performance and preventing more significant damages.
Nowadays, the aforementioned two actions are carried out manually in wind towers and, consequently, they are too expensive, not efficient enough, and dangerous, thus deriving in a potential performance reduction. Therefore, with the prototype developed, it is possible to achieve a potential increase in the energy efficiency of wind turbines as a result of lower costs, higher efficiency and a reduction of the hazards associated to the service by means of the EeC WITUR device.
The current similar robotic solutions (mostly from the USA) are exclusively aimed at inspection services.";71429;50000;H2020-SMEINST-1-2014;SME-1;TRATAMIENTO SUPERFICIAL ROBOTIZADO, SL;ES;;; 196568;674549;mainDSS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Intelligent maintenance Decision Support System for the industry;1/05/2015;31/10/2015;;"mainDSS represents a disruptive innovative IT solution supporting industries to improve the performance of their maintenance dept., irrespectively of the industrial sector and the plant size. The key idea lies on the fact that maintenance consultants always extract data from the corporate CMMS in order to assess maintenance data, apply performance indicators, and offer recommendations and audit reports for the management; a process that is obviously time-consuming, error-prone and costly! Capitalizing on this state-of-practice, mainDSS offers a unique IT system that, using a plug-in approach, dynamically bridges with CMMS repositories and builds, piece-by-piece, the current picture of the company's maintenance performance. This picture constitutes the grounds on which mainDSS builds its expected outcomes, namely: maintenance ontology incorporating assessment criteria and KPIs for dynamic auditing, benchmarking for comparatively assess the performance of the industry, time-wise or in relation to other comparable companies, and effective recommendations (DSS) for improvements.

Within this proposal, our main goal is to conduct a feasibility assessment and produce a business plan in order to enhance the current pre-commercial product with additional features and intelligence, and develop a solid product marketing in EU and globally. Highlights:
* Assess viability of planned technical activities for product improvement.
* Develop comprehensive market analysis (EU, global) and market plan, setting up sales network, campaigns and collaborations.
* Study IP issues and decide on patents to be filed.
* Assess economic viability of the venture (projections, market barriers, regulations and other constraints).

mainDSS will have a significant impact to the EU industrial market, as it provides added value to all companies having a maintenance department, looking to improve the management of their assets, increase assets availability and control life-cycle costs.";71429;50000;H2020-SMEINST-1-2014;SME-1;ATLANTIS ENGINEERING AE;EL;MIIT - MANUTENCAO INDUSTRIAL INFORMATIZADA E TECNOLOGIA LDA.;PT; 196525;673874;SBskin;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;SBskin. Smart Building skin;1/05/2015;31/10/2015;;"The aim of the project SBskin is to assess the feasibility and to develop the business plan related to the commercialization of novel solutions of high architectural and technological quality for the increase of the share of renewable energies and, at the same time, for the improvement of the energy efficiency of the building envelope. The innovation project proposed by SBskin is related to the development of multifunctional translucent components for building fac?ades and roofs, made of highly-insulating glassblocks integrated with 3rd generation semi-transparent PV cells and assembled in precast panels through an innovative dry assembly system. The precast system confers high mechanical resistance and enables to easily install at the same time the components of fac?ade and roof and the PV system, which are directly connected to the load-bearing structure of buildings, reducing time and cost of construction and maintenance. The dry-assembly system makes the dismantling process significantly easier for both panels and subcomponents enabling also their easier recycling/reuse.
Moreover, thanks to the features of such innovative PV cells (DSCs), the products proposed by SBskin are also characterized by a wide customizability in terms of colour, transparency and design that can improve their appeal for the BIPV market and their adaptation to the customers needs and the contemporary architecture trends.
In the context of SBskin project and with the collaboration of other companies, in-depth market studies will be finalized also in relation to the countries where PCT related to SBskin products has been extended. Such studies will include a detailed price analysis and a large user involvement, in order to define the best strategy to launch the products in the target market, starting from possible installations in first pilot sites.";71429;50000;H2020-SMEINST-1-2014;SME-1;SBSKIN. SMART BUILDING SKIN S.R.L.;IT;;; 196614;642889;MEDICIS-PROMED;SIGNED;H2020-EU.1.3.1.;MSCA-ITN-2014-ETN;H2020;MEDICIS-produced radioisotope beams for medicine;1/04/2015;31/03/2019;;"Pure accelerated radioisotope beams have been used for 50 years in fundamental physics R&D, e.g. for nuclear structure studies (pear shaped exotic nuclei, Nature 2013); CERN-ISOLDE plays a central role in developing accelerator technologies and fostering collaborative approaches to advance this field of isotope mass separation online. Our most recent contribution was the use of nanomaterial targets for more intense and reliable beam production, and laser ion sources for their purification (discovery of yet unknown 233Francium).
Radioisotopes are widely used for functional imaging in medicine, based on 99mTechnetium or on 18Fluorine. This field is expected to rapidly expand, when coupling imaging with new cancer treatments, with isotopes emitting different type of radioactivity, e.g. alpha particles. This is shown with the recently introduced 223Radium chloride (Xofigo) used as a treatment drug in advanced bone cancers. However, either shortage in the supply of 99mTechnetium or lack of access to new radioisotope with adequate properties is a severe treat to develop personalized treatment that combine functional imaging and therapy.
Ovarian cancers have poor prognosis, are the second most frequent cancer for women and one of the deadliest. They are difficult to treat, because of possible presence of metastasis, and because this region is difficult to irradiate without collateral damages.
MEDICIS-PROMED will train a new generation of scientists to develop systems for personalized Medicine combining functional imaging and treatments based on radioactive ion beam mass-separation. This will be done across a coherent intersectorial multidisciplinary network with world-leading scientists in their field.
Subsystems for the development of new radiopharmaceuticals, of isotope mass separators at medical cyclotrons, and of mass separated 11Carbon for PET-aided hadron therapy will be specifically developed to treat the ovarian cancer.";2829269,88;2829269,88;H2020-MSCA-ITN-2014;MSCA-ITN-ETN;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;"Johannes Gutenberg Universitaet Mainz;Advanced Accelerator Applications;THE UNIVERSITY OF MANCHESTER;INSTITUTO SUPERIOR TECNICO;Fondazione Centro Nazionale di Adroterapia Oncologica - Fondazione CNAO;KATHOLIEKE UNIVERSITEIT LEUVEN;LEMER PAX";"DE;FR;UK;PT;IT;BE"; 196468;672722;Naturhealth Food;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;NATURHEALTH FOOD: NEW GENERATION OF NATURAL BIOPRESERVATIVE SUBSTITUTE OF CURRENT E-NUMBERS IN FOOD PRODUCTS;1/06/2015;30/11/2015;;"Biofactora Naturae et Salus is a biotechnological company created in 2011 which extracts healthy ingredients and additives from fungi and vegetables in order to produce high value foodstuffs. The company has 12 employees and an operational manufacturing biofactory of cutting edge technology.
One of the principal problems in food industry is food preservation. Most food products in the world add chemical preservatives into them (E-numbers). The presence of food preservatives of chemical origin, E-numbers, in food represents a worry for 66% of Europeans. There is international scientific research that concludes that chemical preservatives (E-numbers) can pose health-related problems and environmental problems.

The objective of our project consists on industrially producing a worldwide novelty: a new and natural biopreservative, Naturhealth Food able to substitute the chemical preservatives in food (E-numbers) in most foodstuffs with similar efficacy and a competitive price. This biopreservative will be harmless for people and environment.

In Biofactora Naturae et Salus S.A. we have achieved some milestones. Naturhealth Food has already been successfully manufactured in our biofactory and tried in numerous foodstuffs without affecting their organoleptical properties.
In order to prepare Phase 2 of this project, where the scaling-up of the process and the extension of our facilities will be carried out, we need to conduct a feasibility study of the project (Phase 1). This feasibility study will comprise four main activities: a technical study, a market analysis and customer discovery, an economic study and Intellectual property rights and legal issues.
Our target market is the Food Industry in general. Given that this market is huge to begin with, Biofactora Naturae et Salus proposes to focus on the high value foodstuffs market.
Naturhealth Food sales expectations will be of 35,000,000 per year in 2022 with a net profit of 6,400,000 during that year.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOFACTORIA NATURAE ET SALUS;ES;;; 196565;674502;HySolarKit;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Converting conventional cars into hybrid and solar vehicles;1/05/2015;31/10/2015;;"In the last decade, increasing effort has been put worldwide in reducing the impact on fuel consumption and greenhouse gases (GHG) emissions from passengers cars. HySolarKit introduces for the first time the possibility to modify a conventional car into a plug-in solar-powered hybrid electric vehicle, allowing reduction of fuel consumption and GHG emissions by ~20%, with limited investment cost (~2.500), acceptable payback (2-3 years) and without invalidating performance and safety.
The innovation integrates for the first time state of the art technologies (in-wheel motors, Li-ion battery, flexible PV panel) with an advanced control system, self-adaptive to different vehicle and in-wheel typologies and features.
HySolarKit unique selling points are: i) successful coupling with solar energy ii) applicability to existing fleets, with limited investment with respect to a fleet electrification, iii) flexibility of energy sources.
eProInn will foster the industrial development of the research aimed at a successful commercialization strategy. A preliminary market assessment has already shown huge market potential (~130Ml in Italy only), as well as willingness to pay by main customer categories. Proposer SME has already defined a thorough commercialization strategy, addressing the B2C and B2B main markets, in line with own company strategy. This includes an initial self-financing for R&D development and market validation as well as the technical and capital support of already involved partners (Landi Renzo and Actua), financers (Beijing Rongtong S&T Ind. Group) and subcontractors (Ciaotech), and others identified in Phase 1.
A tentative business plan has already been drafted over a 2\3-year period, showing that with the help of the SME-instrument a positive ROI can be realized already at year 4 (\35%).
Phase 1 project will assess the technical, regulatory and economic feasibility of HySolarKit project and define a convenient commercialization strategy for the product.";71429;50000;H2020-SMEINST-1-2014;SME-1;EPROINN SRL;IT;;; 196618;643555;UNCAP;SIGNED;H2020-EU.3.1.;PHC-20-2014;H2020;Ubiquitous iNteroperable Care for Ageing People;1/01/2015;31/12/2017;;"The lack of ICT platforms based on open standards is regarded as one of the most significant market barriers to the creation of new care & assistance paradigms with global interconnection and interworking. UNCAP delivers an interoperable platform based on open industrial standards that leverages on existing technologies for biosensing, indoor/outdoor localisation and home-automation. The result is an open source, scalable and privacy-savvy ecosystem compatible with existing Personal Health Record systems, that can deliver novel services that can help aging people (incl. those with cognitive impairments) live independently and with dignity.
To do so, UNCAP uses state-of-art physical/cognitive assessment tools together with technologies to locate objects, devices and users within indoor/outdoor spaces, to continuously monitorin a non-invasive way- users and to assist them in case alert conditions are detected.
In practice, UNCAP develops a product suite for formal and informal care environments made of: 1) the UNCAP BOX (an Android consumer device connected to TVs); 2) the UNCAP App for both users and caregivers; 3) the UNCAP CLOUD, delivering scalable care services; 4) the UNCAP certification suite, to help software and hardware manufacturers assess compliancy with standards.
UNCAP will be assessed for 12 months in 14 pilots within real operational scenarios.
Pilots will be located in rehabilitation centres, daily nursing facilities etc. and will involve 750\ users and 220 caregivers. Users physical & cognitive assessment will be carried on before and after the introduction of UNCAP to extract quantifiable metrics to assess its impact in terms of quality of care services and improved quality of life of users and caregivers.
Lastly, UNCA will carry on a RoI analysis (both financial & social), an analysis of best practices of innovative organisational/business models as well as financing/procurement models for health & care service delivery at EU level.";3820763,91;3086254;H2020-PHC-2014-single-stage;IA;TRILOGIS SRL;IT;"SIEMENS SRL;GiStandards LTD;CREATE-NET (CENTER FOR RESEARCH AND TELECOMMUNICATION EXPERIMENTATION FOR NETWORKED COMMUNITIES);INI-NOVATION GMBH;ARISTOTELIO PANEPISTIMIO THESSALONIKIS;FIDA SOLUTIONS SRL;SOCIALIT SOFTWARE E CONSULTING SRL;DOM DANICE VOGRINEC MARIBOR;REPUBLIC OF MACEDONIA GOCE DELCEV STATE UNIVERSITY STIP;Future Shape GmbH;AZIENDA PROVINCIALE PER I SERVIZI SANITARI;ORASUL SIMLEU SILVANIEI;ZIGPOS GMBH;CADZOW COMMUNICATIONS CONSULTING LIMITED;UNIVERZA V LJUBLJANI;AZIENDA UNITA LOCALE SOCIO SANITARIA N 5 OVEST VICENTINO;UNIVERSITA DEGLI STUDI DI TRENTO;BIOASSIST SA;ATOS SPAIN SA;UNITATEA ADMINISTRATIV-TERITORIALA BAIA SPRIE;FONDAZIONE BRUNO KESSLER;COMBAIN MOBILE AB";"RO;UK;IT;DE;EL;SI;MK;ES;SE"; 196566;674510;Virtual Private Home;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Virtual Privte Home - Privacy-by-design Home Energy Efficiency Platform;1/05/2015;31/08/2015;;"Project objective
Virtual Private Home Privace-Aware Home Energy Efficiency Platform project aims to deploy on the EU market a new, gaming changing energy efficiency tool for residential customers, that will be characterized by its superior energy saving performance, open architecture and above all by its Privacy-by-design data protection concept.

Product concept
The Virtual Home product will be released in a form of an online service, accessible via internet, mobile and smart objects. The service will be associated with third party smart meters and smart home devices. It will use behavioral efficiency (green nudge) tool to engage consumer in energy saving, and its modular structure will enable connecting an infinite range of additional applications. It can enable to up 30% of energy savings. Each end-user will dispose of complete control of its private content, with a possibility to grant or revoke access, change hosting platform, destroy all data. The encrypted object storage approach will ensure access on need-to-know bases.

Feasibility assessment
The feasibility phase will validate initial market insights: demand for privacy solution, size o home energy efficiency markets, and test concepts with initial test users.

European and global dimension
Residential energy consumption represents 27% of overall EU energy usage, and energy expenses start to exceed 10% of household budgets in some EU countries. EU directives recommends deployment of smart metering and smart grid solution, while the new EU General Data Protection Regulation imposes very strict privacy by design rules. Privacy is a major barrier for deployment of home energy efficiency solutions.

The project will be coordinated by GridPocket, successful start-up of 15 engineers and researchers based in France and Poland.";71429;50000;H2020-SMEINST-1-2014;SME-1;GRIDPOCKET SAS;FR;;; 196638;651892;SEDEUF;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Sedicii Innovative Authentication;1/10/2014;31/03/2015;;Sedicii Innovations was formalised in December2013 with the objective to commercialise, promote & support innovative methods of authenticating users online (based on 4 years of academic research).Achievements include US Patent,Independent Audit receipt, BT winner, shortlisted with TechCrunch, MasterCard,&others and 2 pilots (BT & Gemalto).We received positive feed back &have identified many opportunities in gaining market/user acceptance.This feasibility study will help further research & address such opportunities/challenges to establish reference clients&users in building a sustainable business.Challenges include:A.Gain paying customers&market creditability through reference users, coupled with independent, endorsements. B.To further finance development of the Sedicii solution to meet with market needs. Sediciis method of authenticating a user can be applied to different user authentication needs.These include: a)Single Sign-On Authentication:Market Value of over 1 Billion annually.b)Credit Card Tokenization: Market Value of $5BN annually.c)Identity Verification: Market Value in excess of 5BN annually.Sediciis methods will benefit both consumers & suppliers of digital commerce/services.The ability to authenticate a user without the need to store or expose the personal information of the user will provide significant benefits to holders of such data. With the imminent development of new & evolving markets based on the Internet of Things, it is expected that over 100BN devices will be connected to the internet in the future, which will require stronger security,authentication to protect personal data.Sedicii expects to achieve 3objectives during the feasibility study:1.Identify targeted customers in defining the Sedicii solution to meet market needs.2.Explore commercial models & secure the regulatory / industry endorsement as part of the launch & commercial efforts.3.Educate/profile to a wider EU audience, including those responsible for data protection/privacy.;71429;50000;H2020-SMEINST-1-2014;SME-1;Sedicii Innovations Limited;IE;;; 196581;653750;CIP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Categorical Interoception Project: How generalization and classification strategies link anxiety and interoception;1/04/2016;31/03/2018;;"Bias in the perception of bodily sensations (interoception) can be dangerous or even fatal; for example, if we do not recognize signs of a stroke or take medication anytime we feel the slightest change in our body. Research consistently reports that anxiety is closely related to interoception and (mis)interpretation of bodily sensations, but little is known about more fundamental processes underlying this relationship. The aim of this project is to test whether categorization as basic perceptual process links anxiety and interoception via generalization and perceptual decision strategies.
Bundling the continuous flow of interoceptive information into distinct categories such as pain or pleasure can facilitate perception and coping. By assigning sensations to interoceptive categories (e.g., symptom groups) we can infer information about causes and consequences and apply coping schemata fast and efficiently. Research on visual perception, however, suggests that anxiety can be related to excessive generalization which may turn into harmful over-generalization, particularly if stimuli are misclassified. We will test whether also in interoception, anxiety is related to excessive category-related generalization. Furthermore, we will test whether individuals higher in anxiety are more prone to take a better safe than sorry strategy and misclassify benign sensations (e.g., heartbeat and breathlessness associated with exercise) more often as sign of disease.
We will test our hypotheses of categorization linking anxiety and interoception in a newly developed research paradigm. In contrast to traditional paradigms, it allows distinguishing interoceptive accuracy and bias. The project is of theoretical relevance by targeting fundamental processes linking anxiety and interoception. Furthermore, it is of clinical relevance by testing the relationship between anxiety and interoceptive classification strategies, which are related to choices in health behaviour.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DU LUXEMBOURG;LU;;; 196499;673380;CaNE-HiP-LA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Carbon Nano Materials Enabling High-Performance Lead Acid Batteries;1/03/2015;31/05/2015;;"The objective of this innovation project is to address the lead acid battery industrys growing technology and market challenges through a Carbon-Nano Materials technology solution which dramatically enhances L.A. battery performance, without altering battery design or existing manufacturing processes, and at a nominal cost to the manufacturer. By doing so we will create a direct $2B / annum market opportunity across our value chain, substantially reduce the huge environmental footprint of the lead acid industry, advance European objectives in vehicle emissions reduction, and reinforce European leadership in nano-technology.
Over the past 5 years, L.A. battery manufacturer Vulcan, together with its partners France-HQ'd Carbon Nano Materials market leader Arkema, and Bar Ilan Universitys nanotechnology and battery experts - have been developing a disruptive Carbon Nano Materials-based technology solution, branded VoltaNano, specifically targeted at the L.A. industrys growing market challenges. VoltaNano-enhanced batteries now achieve over 100,000 ignition cycles on average based on a standard flooded battery platform, compared to the industry standard of ~30,000 cycles. Medium DoD cycle life is more than doubled. A novel method was invented to allow optimal dispersion within the lead acid matrix and enable seamless introduction into existing fabrication lines. Bill of materials was driven down to meet industry targets. VoltaNano is already integrated into Vulcan's own production line, and in-vehicle testing is in advanced stages. The objective of the feasibility study of phase 1, is to build a comprehensive business plan for the international dissemination of VoltaNano to lead acid manufacturers worldwide through a packaged license, service and materials-supply offering. Beyond this key objective, we will aim to achieve regulatory compliance, complete the in-vehicle testing program, and establish a first international pilot towards commercial launch in Phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;VULCAN AUTOMOTIVE INDUSTRIES LTD;IL;;; 196526;673822;GEPLAER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;PLASTIC AEROSOL CONTAINER;1/05/2015;31/10/2015;;"Europe is the region with the largest aerosol production volume and consumption worldwide: 5.5 billion units produced in 2013. European Cosmetic and personal care sector represents 57% of this production.
Metal containers have been widely used because of their good conformability, resistance, and UV and light protection. However, metal containers are prone to rust and to internal corrosion unless an appropriate coating is applied to prevent this. Polyethylene-terephthalate (PET) aerosols can provide an environmental and lower-cost alternative to tinplate or aluminium cans, offering design flexibility, a variety of different shapes and styles which can be created with lower weight, and corrosion resistance. However, an improvement of overall properties is required, as nowadays, no plastic aerosol container can provide overall the resistance values required in the Aerosol Dispensers Directive (ADD). The market share of personal care products is around 3.1 billion containers solely in Europe, providing an attractive business opportunity.
The GEPLAER project aims to replace metal containers with novel plastic aerosol with higher pressure resistance (11 bar), complying with current ADD requirements, and considering those which will be applicable in the near future, while offering novel aesthetic and functional properties, such as transparency.
In order to assure a wider penetration of our PET aerosol in the market (mainly personal care and secondly food), GEPLAER work plan includes: a technical feasibility analysis, a market and stakeholder analysis, and a business plan.
We expect to commercialize this product on 2017. After 5 years, we expect to sell 187.85 million PET containers (NPV of 4,541,601 and an IRR of 71%). It implies a substitution of 21,302 tonnes of metal with 6,574 tonnes of PET, having environmental, economic and social benefits for all members of the supply chain (PET manufacturers, packers and fillers, transport companies).";71429;50000;H2020-SMEINST-1-2014;SME-1;GEPACK EMPRESA TRANSFORMADORA DE PLASTICOS SA;PT;;; 196553;674155;GREEN BLADE;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;THE NEW SUSTAINABLE EXOTIC VENEER FROM THE FRENCH CARIBBEAN;1/05/2015;31/10/2015;;"FIBandCO aims to develop a new exotic veneer made from banana plan trunks as a clean alternative to wood: GREEN BLADE, an exceptional coating, 100% natural and eco-designed.
At the end of their life cycle, banana plants die on the spot and grow again from their bulb. Previously, after the harvesting of bananas fruits, trunk was naturally decomposing. Now, the trunks of banana trees are harvested by hand and used to create value through this unique veneer and other products. This process doesnt use water nor chemicals. FIBandCO recycles this abundant agricultural waste, grab as a particularly virtuous renewable raw material.
The company proposes the whole value chain, from the innovation concept to the commercialization of the products. The objectives of the company are to provide and market turnkey factories for banana planters, so they can exploit this raw material throughout the year.
Established in Martinique in 2009, FIBandCO gives a second life to banana plant trunks. FIBandCO has been created to develop and exploit commercially this idea. Up to now, the solution is operational and credible, it allowed the company to two rounds of investment for a total amount of almost 2 M in 2013 and December 2014. To go further it is necessary for FIBandCO to pursue the definition of the commercial plans and the overall strategy for the next two years.
Preliminary work and experiments have led to the concept validation, production process definition, and patent filing. The veneer turnkey factory prototype has been developed and tested in relevant environment (TRL 6) allowing to produce prototypes and samples of GREEN BLADE.
The final green economy outcomes and disruptive model perfectly fit with SC5-20-2014-1 call. This phase I will help our company to hit the market with a clear strategic view in terms of business model, R&D and IPR. Whit this SME Instrument deliverables, and hopefully subsequent phase II, FIBandCO can expect a strong growth during the next few years!";71429;50000;H2020-SMEINST-1-2014;SME-1;FIB AND CO;FR;;; 196604;636778;FACTS4WORKERS;SIGNED;H2020-EU.2.1.5.1.;FoF-04-2014;H2020;Worker-Centric Workplaces in Smart Factories;1/12/2014;30/11/2018;;"It is the high ambition of the project to create FACTorieS for WORKERS (FACTS4WORKERS), therefore a serious effort will be put into integrating already available IT enablers into a seamless & flexible Smart Factory infrastructure based on worker-centric and data-driven technology building blocks. As FACTS4WORKERS is underpinned by a clear human-centric approach: usability, user experience and technology acceptance are of the utmost project interest.
FACTS4WORKERS will develop and demonstrate workplace solutions that support the inclusion of increasing elements of knowledge work on the factory floor. These solutions will empower workers on the shop floor with smart factory ICT infrastructure. Advancement will be gained through integrating several building blocks from a flexible smart factory infrastructure, focusing on workers needs, expectations and requirements, and being supported by organisational measures and change management. In line with our assumptions on impacts on productivity we therefore estimate that that we can increase job satisfaction for 800,000 European workers by the year 2025.
These solutions will be developed according to the following four industrial challenges which are generalise-able to manufacturing in general: personalised augmented operator (IC1), worked-centric rich-media knowledge sharing/management (IC2), self-learning manufacturing workplaces (IC3) and in-situ mobile learning in the production (IC4).
Moreover, FACT4WORKERs objectives in terms of measureable indicators are:
To increase problem-solving and innovation skills of workers;
To increase cognitive job satisfaction of workers;
To increase average worker productivity by 10%;
To achieve TRL 5-7 on a number of worker-centric solutions through which workers become the smart element in smart factories
The smart factory demonstrator will be run within the automotive supply chain. The consortium is composed by 15 partners from 7 different EU member states.";7916441,25;6344544,38;H2020-FoF-2014;IA;Kompetenzzentrum - Das Virtuelle Fahrzeug, Forschungsgesellschaft mbH;AT;"THYSSENKRUPP STEEL EUROPE AG;TECHNISCHE UNIVERSITAET WIEN;HIDRIA TC Tehnoloski center d.o.o.;LAPPEENRANNAN TEKNILLINEN YLIOPISTO;SCHAEFFLER TECHNOLOGIES AG & CO. KG;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;THERMOLYMPIC SL;EVOLARIS NEXT LEVEL GMBH;INSTITUTO TECNOLOGICO DE ARAGON;UNIVERSITAET ZUERICH;EMO-ORODJARNA DOO;UNIVERSITA DEGLI STUDI DI FIRENZE;SIEVA, PODJETJE ZA RAZVOJ IN TRZENJ V AVTOMOBILSKI INDUSTRIJI DOO;IMINDS;HIDRIA ROTOMATIKA DOO, INDUSTRIJA ROTACIJSKIH SISTEMOV";"DE;AT;SI;FI;BE;ES;CH;IT"; 196606;638327;A2F Conference;SIGNED;H2020-EU.2.2.;RISK FINANCE;H2020;Presidency Conference on Access to Finance for Research, Innovation and Growth;1/04/2014;30/09/2014;;"The Innovation Union (IU) is a flagship initiative of the Europe 2020 Strategy which has a central role in achieving the goals of the Europe 2020 Strategy for a smart, sustainable and inclusive economy. It is aimed at improving conditions and access to finance for R&I in Europe, to ensure that innovative ideas can be turned into products and services that create growth and jobs. The IU contains over thirty action points including a key point for Enhancing access to finance for innovative companies. According to the ECs proposal, the EU needs to put in place financial instruments to attract a major increase in private finance and close the market gaps in investing in R&I.
Horizon 2020 is the financial instrument aimed at implementing the IU. By coupling R&I, Horizon 2020 focuses on excellent science, industrial leadership and tackling societal challenges. Under the 'Industrial Leadership' pillar, Horizon 2020 supports companies and other organisations engaged in R&I to gain easier access, via financial instruments, to loans, guarantees, counter-guarantees and hybrid, mezzanine and equity finance.
Currently, the priority is to continue and build on activities that have been worthwhile in supporting R&I in 2007-2013 such as the RSFF, the RSI for SMEs and GIF-1. Horizon 2020's financial instrument facilities will also operate in conjunction with those of EU programme COSME, and the coming two years will see, a significant participation by Horizon 2020 in the proposed SME Finance Initiative; the launch of a pilot facility supporting the technology transfer process; and a new focus on improving access to risk finance by larger midcap firms.
The overall objective of the conference is to raise awareness of the financial instruments, facilities and accompanying measures launched under Horizon 2020 and to enhance access to finance for R&I and growth. Focus will be given to the interactions between these instruments, COSME, and ESIF as well as with instruments at national";120000;120000;H2020-Adhoc-2014-20;CSA;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;;; 196550;674102;SOLARGE45;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Towards a SOLAR enerGy Efficiency of 45 %;1/05/2015;30/09/2015;;"The overall objective of the SOLARGE45 project is to accelerate the market introduction of a new Concentration PhotoVoltaic (CPV) technology, called the MF45 System, which yields the highest efficiency all year round, without giving up simplicity, and therefore enables the lowest manufacturing costs. The MF45 System will be capable to convert the equivalent of 45% of the direct sun light into clean electricity at costs equivalent to those of conventional sources (CO2 intensive). This represents conversion efficiency increases of 30% and 60% relative to other commercial CPV systems and FP systems, respectively.
As result of the SOLARGE45 project, LPI aims to become a worldwide reference manufacturer and supplier of a novel CPV System able to generate profits in large-scale utility solar plants, and without the support of government policies backing up clean electricity. This will bring a positive impact in the challenge stressed in the 'Secure, Clean and Efficient Energy' Work Programme: low-cost, low carbon electricity supply.
Through the Phase 1 of the SME Instrument LPI will be able to assess the industrial and commercial feasibility of the business innovation project proposed for introducing the MF45 System into the market. The specific objectives that must be achieved in the course of the Feasibility Study are the following:
- To define the MF45 System specifications needed to assure long-term-performance under real operation conditions to guarantee product bankability and standard certification
- To assess different product-development and industrial process pilot plant alternatives with optimal quality within cost and reliability balance
- To identify the specific operational and financial resources and/or partners to cover the whole MF45 System manufacturing and commercialisation
- To assess the feasibility of the preliminary Market Strategy and Commercialisation Plan, by an in-depth study of the MF45 System market size and barriers.";71429;50000;H2020-SMEINST-1-2014;SME-1;LIGHT PRESCRIPTIONS INNOVATORS EUROPE SL;ES;;; 196607;640199;EPIC;SIGNED;H2020-EU.2.1.6.1.;COMPET-03-2014;H2020;Electric Propulsion Innovation and Competitiveness;1/10/2014;30/09/2019;;"EPIC proposes a Programme Support Activity which will produce a clear integrated roadmap & masterplan for its implementation through a Strategic Research Cluster (SRC) on In-space Electrical Propulsion & Station-Keeping.
EPIC plans to do a survey of the current worldwide Electric Propulsion (& related) technologies & their TRL. A collection of requirements from all stakeholders will be done, also assessing potential future missions. Both tasks will build on the 2014 EP Harmonisation & the consultation will be expanded to all EU actors. This will allow to focus efforts on the SRC roadmap specific goals.
Based on this work, a critical gap analysis of technologies & needs will be done, to create the basis for selection of candidate SRC developments, oriented to satisfy short-term (incremental advances) & medium/long term (disruptive) needs.
Then the prioritisation will be the driver & challenge, leading to the selection of activities for an SRC roadmap & masterplan for its implementation, aiming at a validation flight in 2023 & to contribute to European leadership in EP technologies.
EPIC will provide a solid & widely consulted advice to the EC on the call texts for operational grants & continuous support to EC/REA to maximise the SRC success. EPIC will analyse the SRC progress, evaluate its risks & put a mitigation plan in place, including the Collaboration Agreement.
The EPIC consortium will disseminate its progress & results, & intends to contribute to the SRC results dissemination not only with an exploitation plan but also by exercising a close coordination with all operational grants.
EPIC is coordinated by ESA & complemented by renowned National Agencies: ASI, BELSPO, CDTI, CNES, DLR & UKSA, & by the major European space industrial associations, Eurospace & SME4Space. This teaming of beneficiaries brings together the multidisciplinary mix of expertise required to deliver an unbiased, rational strategic roadmap & masterplan for EP developments in H2020.";3496351;3496351;H2020-COMPET-2014;CSA;EUROPEAN SPACE AGENCY;FR;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;EUROSPACE;UK Space Agency;CENTRE NATIONAL D'ETUDES SPATIALES - CNES;AGENZIA SPAZIALE ITALIANA;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;SERVICE PUBLIC FEDERAL DE PROGRAMMATION POLITIQUE SCIENTIFIQUE;SME4SPACE VZW";"DE;FR;UK;IT;ES;BE"; 196551;674107;ATRS Instrument;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Real time analysis of tablet and capsule dosage during pharmaceutical manufacturing;1/04/2015;30/09/2015;;"The objective of the overall innovation project is to develop a novel instrument to measure and control pharmaceutical drug potency during manufacture at sub-second analysis speeds. This will significantly reduce the cost of quality testing, reduce the dosage variability that a patient receives, reduce production waste and solvent disposal and address challenging new regulatory testing guidelines.

Pharmaceutical companies, in response to regulators (such as the US FDA) setting direction and guidance, need to better understand and control their processes. Real-time release testing (RTRT) and Quality by Design (QbD) are promoted by regulators as their vision of where quality must go; pharmacopeia guidance supports that vision.

Cobalt has developed a successful, patented, high speed quantitative analysis technology called transmission Raman spectroscopy (TRS), which measures drug potency of intact tablets and capsules. When used during production (on-line) in combination with an automated physical tablet testing system, TRS will enable immediate release of drug product without off-line analysis in a quality control (QC) laboratory.";71429;50000;H2020-SMEINST-1-2014;SME-1;COBALT LIGHT SYSTEMS LIMITED;UK;;; 196510;673505;Aerowash II;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;InnovAtive automatic battERy pOwered WASHing robot for the aviation industry Aerowash II;1/05/2015;31/10/2015;;"Nordic Ground Support Equipment AB (NGSE) plans to install 5 to 10 demonstration units of the worlds first fully automatic, battery powered aircraft washing robot, at 3 to 5 different airports within the EU (i.e. operational environment). Compared to state of the art, the robot will decrease washing time by approx. 40-60%. The robot will also decrease water and chemical consumption by approx. 20-30%. This will have a positive impact on EU aviation industry since it will allow them to lower the down time of airplanes and decrease congestion at the airports.

The core objective of the feasibility study (phase 1) is to select three to five airport locations in the EU, (e.g. main hubs like Charles De Gaulle Paris France, Heathrow London UK, Frankfurt Airport German, Madrid-Barajas Madrid Spain and Kastrup Copenhagen Denmark) to analyse the pre-requisites/conditions for a successful implementation of the automatic washing robot on the European market. The feasibility study will include both technical/practical and commercial aspects in order to secure a successful deployment and implementation of the innovative washing system.

By implementing NGSEs fully automatic airplane washing robot a normal airline can save around 37 000 man-hours annually and 5-7 million litres of water. In addition the robot is battery powered (compared to state of the art, semi-automatic systems which are in general diesel powered) which means it can be used at any airport location, indoors or outdoors, hence it is much safer, greener and more user-friendly than any other alternative available today.

The expected growth in passenger aircrafts globally requires aircraft maintenance routines to become more efficient, as airports are constantly getting more and more overcrowded. With a global market size of several thousand of the worlds first fully automatic washing robot, with a total value of approx. 1-1.5 Billion EUR, the potential business opportunity for NGSE is clear.";71429;50000;H2020-SMEINST-1-2014;SME-1;Nordic Ground Support Equipment AB;SE;;; 196481;672930;BrainPEER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Brain Performance Enhancement Revolution - Advanced Cognitive Training System for Football Players;1/05/2015;30/04/2017;;"The BrainPEER project aims at presenting a highly effective brain-training system for football players. It will do so by adopting ACEs patented Cognitive Simulation technology to football, demonstrating it with elite football academies, then run field trials with individual youth players.
Football is the worlds most popular sport. Due to its competitive nature, football players of various ages are in a constant quest to improve their game and win. Some aspire to reach fame and financial prosperity. Others seek higher social status and acceptance. That aspiration is intensified by the extensive media coverage of elite athletes. According to football experts, the main differentiating skill between good football players and average ones is game intelligence. Alas, there are currently no effective tools to improve this critical aptitude.
ACE proposes an innovative and highly effective cognitive training program, addressing football-related cognitive skills such as spatial awareness, anticipation, and decision making.
The outcome of the project will be a market-ready brain-training product for football players of all ages and skill levels the Football IntelliGym. The program is designed as a friendly video-game, will be compatible with mobile devices, and at an affordable price.
The Football IntelliGyms target market is 265 million football players, of which 61 million are in Europe.
ACE is a pioneer and market leader in the field of cognitive training for athletes. It has already proved the concept both technologically and commercially - with ice-hockey in North America. ACEs strategy is to present its revolutionary training concept in sports first, where performance is highly visible and constantly quantified. This will pave the way to presenting effective brain trainers for other complex and cognitive-challenging professions such as first-responders, medical staff, operators of control centres (e.g. airport controllers and smart city officers), and drivers.";2666875;1866812,5;H2020-SMEINST-2-2014;SME-2;ACE APPLIED COGNITIVE ENGINEERING LTD;IL;;; 196453;672591;DISA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;medical Diagnosis Support Armchair project;1/05/2015;31/10/2015;;"The Diagnosis Support Armchair project aims at collecting, in a very short time (7minutes max.), all medical data from the elderly persons body and send them to the nearest medical center or doctor. This could allow an easy follow-up of chronical diseases in nursing or elderly residential homes and give all necessary elements to establish a diagnosis and make a quick decision. Beyond the elderly population, this type of connected e-health armchair can be used with any age population in all medical and emergency centers.
The specific objective of the feasibility study is to evaluate the armchair interests for patients and get support from medical professionals at French and European level. With the development of many non-invasive sensors on a mobile and easy-to- use armchair, StreamVision wants to facilitate the work of many medical helpers by bringing in a very easy, quick and accurate manner an answer to medical deserts in remote regions or countries.
To do so, StreamVision proposes to work with emergency hospitals and nursing homes so as to define and validate the various non-invasive sensors necessary to make the chair useful. This feasibility study with medical players must help Streamvision to develop scenarios of industrialization and commercialization at EU level. Several steps must be accurately designed such as : protocols, user and medical players involvement and acceptance, standardization and certification process, business model and obviously security in the medical environment.
This study will comply with the French national law (the CNIL) and there is no specific ethics issues excepted the elements mentioned in the proposal.";71429;50000;H2020-SMEINST-1-2014;SME-1;STREAM VISION;FR;;; 196626;644748;CLOUDWATCH2;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Think Cloud Services for Government, Business Research;1/09/2015;30/09/2017;;"CloudWATCH2 supports EU R&D on cloud computing, software, services across the full innovation lifecycle & the move to market, promoting technology advancements, supporting OS software re-usability through clustering, championing standards for interoperability & security, providing a roadmap on the cloud market structure to encourage transparent pricing & offering educational services on risk management & legal issues to lower adoption barriers for SMEs & public administration. CloudWATCH2 focuses on the cloud ecosystem emerging from EU research & innovation projects, where technology & pricing are an equally important part of market equation. It takes a pragmatic approach to market uptake & sustainable competitiveness by clustering projects around common themes & challenges, with deep dive training for wider uptake & commercial exploitation. It analyses the fast evolving standards landscape, new implementations, extensions & protocols focusing on the value creation of interoperable and secure services, identifying gaps & making recommendations to address them. It brings interoperability testing to the forefront supporting Cloud Interoperability Plugfests. It supports market-oriented approaches to new products, services & solutions, including OS developments, where free & profitability are not mutually exclusive. It introduces a novel activity around cloud pricing analysis, strengthens support of sustainability, to encourage faster time-to-value & commercialisation of innovative products & services. On the demand side, it supports key stakeholders in the EU digital market by providing training on legal aspects addressing increasingly common consumer concerns. Consortium: TRUST-IT, coordination, outreach, a renowned international network & SDO liaisons; CSA a leading, global player in cloud security; UOXF OeRC part of UK eScience programme; StrategicBlue cloud billing & price risk management experts. ICT Legal, represents IT, ISP, SW, CSP, IoT & IT service vendors";585001;585000;H2020-ICT-2014-1;CSA;TRUST-IT SERVICES LIMITED;UK;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;STRATEGIC BLUE SERVICES LIMITED;CLOUD SECURITY ALLIANCE (EUROPE) LBG;ICT LEGAL CONSULTING - STUDIO LEGALE ASSOCIATO BALBONI BOLOGNINI & PARTNERS";"UK;IT"; 196627;644859;SOMATCH;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Support IT solution for creative fashion designers by integrated software systems to collect, define and visualize textile and clothing trends through innovative image analysis from open data;1/01/2015;30/06/2016;;"The objective of the SOMATCH is to improve the competitiveness of EU SMEs in Textile and Clothing (T&C) and design focused sectors by the collection, definition and visualization by ad hoc interfaces of fashion trends. SOMATCH will provide creative designers with detailed and reliable trends estimations and forecasts of user acceptance. Its goal will be achieved by the creation of an innovative tool for the mining and visualization of large sets of unstructured data, related to the use and preferences of fashion products by consumers, supporting T&C companies quick reaction to the market dynamics and better adaptation of design to real consumers demand.
SOMATCH faces this complex and challenging deal by the combined development and application of SoA advanced image analysis technology, unexploited and innovative in clothing and fashion, combined with social network analysis. Its results will be presented to interested end users by dedicated interfaces and instruments: mobile devices as well as ad hoc visualization tools will be explored for this purpose.
The visualisation of the generated data will be performed from off-line statistics, generated after data processing, and by new real-time instruments for image collection and evaluation of designs. They will be targeted also by the integration of the systems with new SoA mobile and wearable (for ex. Google Glass) devices to collect information and to visualise trend interpretation. This approach will open a vast field of new approaches for the fashion designers, supporting final users involvement into the whole trend evaluation and a close interaction with them.
To reach this purpose Somatch consortium includes research centres expert in image and content analysis (TUM, UPC), software providers experts in data management, platform development and fashion tools (Holonix. Sparsity, Ideal), end users from SME textile industry and retail (DENA) and social networking and e-commerce (Weblogs, NJAL).";1223875;975062,5;H2020-ICT-2014-1;IA;UNIVERSITAT POLITECNICA DE CATALUNYA;ES;"TECHNISCHE UNIVERSITAET MUENCHEN;WEBLOGS SL;MANDELLI LAURA;SPARSITY SL;NOT JUST A LABEL LIMITED;I-DEAL S.R.L.C.R.;HOLONIX SRL-SPIN OFF DEL POLITECNICO DI MILANO";"DE;ES;IT;UK"; 196484;672942;NZE Buildings;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Developing replicable and cost effective Nearly Zero-Energy' building solutions for small builders in Europe;1/05/2015;31/10/2015;;"'The building sector is responsible for the majority of the energy consumption in the world. It is also a key challenge for the 20-20-20 strategy of the EU.

Sustainable housing starts with 'near zero-energy' buildings, i.e. homes that are so well insulated that it becomes easy to produce more renewable energy on site than what is consumed.

Today, house construction in Europe is mainly performed by craftsmen who are small local builders and who work with traditional technics and who are not keen to invest on research and development of Modern Methods of Construction (MMC). As a consequence, it remains very difficult for consumers and investors to buy 'plus energy' houses in Europe (costs and lack of offer due to lack of know-how).

The objective of the project is to provide to local builders the products and the tools so that they can offer to their customers 'nearly zero-energy' buildings with guaranteed performance and cost controls.

To do so, ECOXIA has developed the concept of 'Smart Envelope'. Built in the ideal conditions of the factory, the envelope is installed in a 'Plug & Play' way on site in one day. It includes both energy performance and the components to make it smart.

ECOXIA developed a prototype in 2012 to check the performance of its building envelope. Installed in Yerres, France, it proved the interest of the concept from a mechanical, thermal, comfort and cost standpoints. The recorded consumption proves that the prototype is a 'plus energy' building with the production of only 20 sqm of photovoltaic solar panels.

To be able to commercialise the right solution and help Europe to develop a new industry, ECOXIA needs to go further into its feasibility study by addressing the following questions:
- which is the best level of prefabrication?
- how can we improve the price of our solution for the European market ?
- who are the best potential partners for our project in Europe?
- what are the regulatory issues on the most relevant markets in Europe?'";71429;50000;H2020-SMEINST-1-2014;SME-1;ECOXIA SAS;FR;;; 196512;673556;eKuore;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;eKoure: the worlds first wireless stethoscope of the mhealth market.;1/05/2015;31/10/2015;;"Kukupia aims to make citizens health monitoring possible from home through the use of ICT medical tools connected to the patients and/or doctors smartphones to enhance diagnosis quality, clinical follow-up and disease prevention. eKoure is a wireless stethoscope that allows to detect possible cardiac abnormalities using Bluetooth technology to transmit audio auscultation to ICT devices. Through a mobile application, the tool allows to save audio auscultations, display different parameters (such as heart rate or breathing), and even share the recorded auscultation with other users (whether customers, students or specialists) to simultaneously analyse the information, easing health or treatment monitoring.
These features make eKuore, the worlds first wireless electronic stethoscope with smartphone connection, which further improves the quality and power of the sound up to 20 times compared to traditional stethoscopes.
eKuore is the Kukupias first product and has been designed and manufactured entirely by the companys R&D team based on the success of the device for veterinarian application, with the aim of introducing the product into the healthcare and chronic patients markets.
Currently there isnt in the market a stethoscope with such high audio quality which furthermore allows audio auscultations storage and sharing with other users through smartphones, tablets or computers.
The potential users can be grouped in professionals (doctors from all kind of medical specialities, in particular pulmonologists and cardiologists, students, practitioners, teachers, telemedicine companies, etc.) and individuals (particularly chronic cardiovascular patients). The implementation of the studies planned for phase 1, will contribute to define the products commercial design, manufacture and marketing strategy enhancing the quality of the companys business plan and contributing to market replication success.";71429;50000;H2020-SMEINST-1-2014;SME-1;CHIP IDEAS ELECTRONICS SL;ES;;; 196628;645479;E-JADE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Europe-Japan Accelerator Development Exchange Programme;1/01/2015;31/12/2018;;"The Europe-Japan Accelerator Development Exchange Programme (E-JADE) addresses the urgent need of exchange of ideas on R&D and implementation of future accelerators for particle physics. It does so by exchanging accelerator scientists and experts between Europe and Japan.
The recent European Strategy for Particle Physics and the Japanese Roadmap identify similar pressing goals of research for the next decades. The strategy emphasises the exploitation of the Large Hadron Collider (LHC) and its upgrades, preparation of the cases for new facilities at the energy frontier (FCC or CLIC), identifies the opportunities for electron positron collisions (ILC), particularly after the recent discovery of the Higgs boson, and recognises the need for a long baseline neutrino programme at J-PARC in addition to the BELLE II programme of KEK.
The user community at these facilities is international: a strong contingent of Japanese researchers from KEK and universities work on the ATLAS experiment, highly qualified experts from KEK contribute to the LHC itself, some two thousand researchers worldwide have signed the ILC design report and several hundred physicists are actively engaged in accelerator studies, such as on ATF to explore concepts generally applicable to linear colliders. The J-PARC neutrino experiment, with a strong European participation, has recently published important scientific results.
The planned exchange of staff of leading European Laboratories and Universities with two prominent Japanese partners, KEK and University of Tokyo will focus on the most critical subjects and profiles namely on the design, R&D and prototyping of the future accelerator facilities mentioned above. Key objectives beyond technical progress are related to sharing of technical knowledge, project organisation, treatment of multiple safety codes for technical equipment, purchase methodologies and industrial capabilities, innovation and networks to significantly advance these projects.";1651500;1651500;H2020-MSCA-RISE-2014;MSCA-RISE;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE";"UK;ES;FR;DE"; 196538;673853;Cryoshelter;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Bringing a new LNG-tank technology to industrial readyness;1/05/2015;31/03/2017;;"Cryoshelter has developed an innovative liquefied natural gas (LNG) tank for heavy duty trucks that provides the first serious European technology to compete with the worlds dominant (U.S.) LNG tank maker that has 98% of the European market.

Available in over 1000 sizes due to its modular design, competitively priced Cryoshelter LNG tanks lower the total cost of ownership for truck operators by providing 30% more fuel capacity (adding 30% vehicle range), lower weight, increased hold time, and reduced maintenance due to greatly improved, long term stability of the insulation vacuum. These features address the most critical technical and economic concerns of the heavy duty truck sector and will revolutionize the commercial prospects for LNG as a fuel alternative to diesel in Europe, North America and elsewhere. The Cryoshelter program fulfils current EU policy objectives to reduce CO2 and diesel particulates as well as expand the market and infrastructure for fuel alternatives to petroleum.

Cryoshelter is at the final stage of research, development, and demonstration (Technology Readiness Level 6), now ready for the last destructive testing and field-testing, the precursor to full certification and market entry. We have pre-market relationships with three types of target customers who have expressed strong interest in the Cryoshelter LNG tank: European truck manufacturers, natural gas vehicle (NGV) system suppliers, and LNG truck operators, all of whom are an integral part of the final testing and commercialization plan.

The proposed program is targeted for the H2020 IT.1-2014-2015 Small Business Innovation for Transport (Phase II) area. The EU funding will enable testing, certification and scaling up for competitively priced production volumes as well as increase production and sales staff to 15 highly qualified engineers in 2017. Cryoshelter will achieve ROI rates of >60% and an EBIT margin of >17% after completing the Horizon2020 project.";2433382,5;1700000;H2020-SMEINST-2-2014;SME-2;CRYOSHELTER GMBH;AT;;; 196567;674527;WONDANTS;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Wonder Ants A new eco-friendly-innovation solution to persistent invasive ants.;1/05/2015;31/10/2015;;Wonder Ants is a brand new eco-friendly-innovation solution to a very persistent problem: invasive ants. Till today, it was quite impossible to solve the problem of invasive ants unless you used chemical pesticides and even in that case ants came back after a short period. Chemical pesticides, though, represent a threat for natural biodiversity, putting at risk peoples animals and pets health, and a negative impact on the environment, standing as a crucial pollution factor for natural resources. Unlike baits, Wonder Ants is a revolutionary bio-repellent introducing an original formula based on a well-balanced mixture of essential oils and natural elements that cannot be uncovered, representing a strong inhibitor factor to invasive ants, preventing the environment from pollution and respecting the eco-system. Wonder Ants provides people with a disruptive solution to the problem: the product can be used indoor and outdoor, has a pleasant scent and it is no toxic or hazardous for people, wild animal, pets and plants. And it does not kill ants, but just flee them from the treated environment with a long residual, respecting their valuable role in the planet eco- system. The new product could be applied both in domestic and several industrial contexts, thus meeting some important aims wanted by the European Commission, which provided for the gradual banning of pesticides and toxic components, harmful to the environment, animals and humans.;71429;50000;H2020-SMEINST-1-2014;SME-1;IMPERIAL EUROPE SRL;IT;;; 196535;673788;EDePDAC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Feasibility study for the validation and industrialization of two diagnostic kits in both ELISA and CLIA formats for the early detection of pancreatic cancer based on the novel biomarkers EZR and ENOA;1/05/2015;31/10/2015;;In this study we propose to investigate the feasibility of the industrial development and validation up to the CE marking of two immunodiagnostic kits based on two novel biomarkers recently identified as specific markers of early stage pancreatic cancer, Ezrin (EZR), and its treatment follow up, phosphorilated alpha-Enolase isoforms 1,2 (ENOA). The assays will detect antibodies to these biomarkers in blood. Pancreatic Ductal AdenoCarcinoma (PDAC) early detection is an unmet medical need in the developed world. Presently this cancer is the fourth leading cause of cancer-related death. The EZR kit, used alone on people at risk for PDAC, is proposed as a tool for an early diagnosis of pancreatic cancer. Blood positivity to both antibodies against EZR and ENOA is of great importance for a correct diagnosis of PDAC and the assessment of its development stage. Finally, the combined use of blood test for Ab-EZR, Ab-ENOA and CA19.9 should provides a robust tool for the general diagnosis of PDAC (100.0% sensitivity and 93.7% specificity). Te study will be conducted together with an expert and well introduced company in the field of IVD having a consolidated distribution network, that will support NatiMab in the assessment of the industrialization process and the market entering, and two companies which have the technical capabilities for the production of the two key components: EZR (GeNeuro) and ENOA (Iris Biotech). The IVD segment for PDAC early diagnosis and therapeutic assessment, including screening of population at risk, is a 3 billion potential market. NatiMab has the ambition to become a key player and first mover in such huge market. The final technological target of Natimab project is the development of a three-marker panel, including EZR, ENOA and CA19.9, which is expected to greatly reduce the need for invasive diagnostic screening. The deliverable of the study will be a feasibility report including a detailed business plan.;71429;50000;H2020-SMEINST-1-2014;SME-1;NATIMAB THERAPEUTICS SRL;IT;;; 196536;673683;EBBR;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Commercialisation of expanded bed biofilm reactor technology for the treatment of waste-, used- or contaminated-water and for improved protection of the aquatic environment and atmosphere.;1/05/2015;31/10/2015;;"ABD will aid transition to a resource efficient, circular economy via wide use of its disruptive, bioprocess intensification technology. This technology will cut business costs and help the EU exit economic crisis through job creation and exports. ABDs first process is nitrification of used water, part of a 4.8 bn global market that we will access. We have developed a full-scale prototype package plant (TRL7) for tertiary nitrification with a UK licensee and have a second UK licensee for landfill leachate. Phase 1 funding is required to evaluate other European markets, identify additional licensees and potential end-users, and revise plans to obtain risk finance for business development. Phase 2 will develop a European network of licensees and end-users and build commercial prototypes (TRL9) for validation across Europe under different regional and climatic conditions, before exporting globally and developing new products.
Our expanded bed biofilm reactor (EBBR) technology has patent protection and can be used for purification of raw or used water, fermentation or biocatalysis. Patents cover a superior biomass support material (ABDite), and design features to maximise process efficiency, and minimise energy consumption and footprint. Use of novel, counter-current aeration and nitrogen-depleted air results in highly efficient oxygen transfer and minimal emission of greenhouse gases (methane and nitrous oxide) from used water. An independent consultant has calculated that our capex and opex is 63% and footprint 70% compared to two, market-leading, nitrification technologies.
The motivation for our nitrification process is to generate income by reversing pollution of the aquatic environment and atmosphere, through oxidising ammonia in used water and minimising the emission of greenhouse gases. Our process will help compliance with the Water Framework Directive in the EU and with the Kyoto Protocol globally, as well as helping to meet UN Millennium Development Goals.";71429;50000;H2020-SMEINST-1-2014;SME-1;ADVANCED BIOPROCESS DEVELOPMENT LIMITED;UK;;; 196495;673233;VINESENTI;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;NEW GENERATION OF HIGH VALUE-ADDED ANTIOXIDANT FOOD INGREDIENTS FOR THE GOURMET CUISINE;1/05/2015;31/10/2015;;"In recent years, we have been witnessing a boom of gastronomic themes and a constant and continuous emergence of new and sophisticated food products in contrast with the simplicity of the traditional cuisine. There are around 2,000 Michelin Star restaurants and more than 20,000 high standing restaurants all over the world. The competitiveness in this sector is very high and there is a necessity of differentiation from the competence, looking for new flavours, aromas and textures that allow their dishes to have high value-added.
VINESENTI is a natural product obtained from the valorisation of grape pomace, a winery by-product. It is a concentrate reddish or ochre powder, depending on the grapes that it comes from, red or white grapes. It has been designed to enhance and enrich recipes because of its benefits related to improvements in the sensory profile, textures and shelf life of dishes. Specifically, this product provides freshness, spiced flavours, sweet tannins and fruity sensations.
The main objectives of the Phase 1 of SME Instrument are to study, evaluate and redefine, if necessary, the different factors of VINESENTI project in order to carry out the Phase 2 successfully. To achieve these objectives, Abro Biotec will carry out a feasibility study which could be divided into the following tasks: a technical study, a market analysis and customer discovery, an economic study and the IPR strategy and legal issues.
VINESENTI will suppose a new niche market for the company because up to now, pharmaceutical and cosmetic industries have been the main end-users of the grape polyphenolic extract; but in the future, restaurants, food companies and people in general will be a new market segment. In consequence, a growth of the company will be achieved and this will result in an increase of its competitiveness, turnover and in job creation.";71429;50000;H2020-SMEINST-1-2014;SME-1;ABRO BIOTEC SL;ES;;; 196494;673225;FGFSTAB;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Industrial Production of Stable Fibroblast Growth Factors for Broad Therapeutic, Research, and Personal Care Applications;1/05/2015;31/10/2015;;Our business concept focuses on development and marketing of stable fibroblast growth factors (FGFs) for medical, personal care and research use. FGFs are currently being tested therapeutically for use in cancer treatment, regenerative medicine, as well as in cosmetics. The FGF-based therapeutic approaches contribute towards promoting active and healthy ageing, which is a societal challenge common to all European countries. Another important application of FGFs is in the highly attractive cancer stem cell research with the extension to clinical applications. FGFs are being used as an essential reagent ensuring that stem cells are kept in the undifferentiated state. However, FGF instability is one of the major bottlenecks preventing wider use of FGFs. The FGFSTAB project will address this instability by computer-assisted design of multiple stabilizing mutations combined with cutting-edge molecular biology techniques. The expected outcomes of the project will be a universal protein engineering platform for designing stable FGFs and the process for manufacturing of stable FGFs that are not commercially available, even though there is a huge market for them. Added value of our innovation compared to existing solutions will be unprecedented stability, dramatic production cost reductions and the absence of harmful additives. Such FGFs will have much broader applicability than currently used natural molecules. Because of the wide range of products based on FGFs nowadays, we expect that the outcomes of the project will help us to access new high-value markets addressing global societal challenges, such as health care, bio-research, and personal care. All these market segments are characterized by the considerable size, growth and potential impact on peoples everyday lives. The phase 1 of the SME instrument will allow us to carry out well-researched feasibility study which will help us to take our business forward with confidence, and ultimately, increase our bottom line.;71429;50000;H2020-SMEINST-1-2014;SME-1;ENANTIS S.R.O;CZ;;; 196438;672287;WETPaC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Water Electricity Telecommunication Package;1/05/2015;31/12/2015;;"Clean water, electricity and communication are crucial for human well-being and sustainable socioeconomic development. Their provision is in deficiency in most rural areas of the world and in specific Mediterranean areas of Europe. Yet, solutions for the above needs are developing very slowly due to lack of funds and the risks associated with payments for the supplied services.
The proposing SME aims to develop and demonstrate an optimised packaged system (WETPaC) to provide these services in a low carbon, energy efficient and sustainable way. Key to overcome the relevant barriers is the development of a remote maintenance and operation system as well as the introduction of smart payment methods for electricity and water.
The innovative aspects of WETPaC will facilitate its financing. This will lead to the involvement of local entrepreneurs who will develop a sustainable business in selling electricity, water and services (e.g. electricity, air conditioned shelters, etc.) to telecom companies.
The main objective of the proposed project is to perform a feasibility assessment and a detailed business plan for the successful implementation of WETPaC.
Based on the results of Phase1, the proposing SME plans to develop and demonstrate a prototype with the help of investors and/or SME instrument Phase 2.
WETPaC will address a global challenge based on European design, components and equipment. Successful commercialisation will provide valuable services that will improve quality of life and will consequently help develop new jobs in Europe as well as in developing countries.
The feasibility study will have as priority the Greek islands where it is suitable for touristic businesses and Philippines where it can supply villages. Other countries will be also examined.
During the study, the proposing SME will contact key stakeholders and potential customers. It will also examine possible technical features that could make the product more affordable and attractive.";71429;50000;H2020-SMEINST-1-2014;SME-1;EYDITI ENERGEIAKOS KAI PERIBALLONTIKOS SCHEDIASMOS EPE;EL;;; 196612;642108;AWESOME;SIGNED;H2020-EU.1.3.1.;MSCA-ITN-2014-ETN;H2020;Advanced Wind Energy Systems Operation and Maintenance Expertise;1/01/2015;31/12/2018;;"AWESOME network aims to educate eleven young researchers in the wind power operation and maintenance (O&M) field by constructing a sustainable training network gathering the whole innovation value chain. The main EU actors in the field of wind O&M have worked together, under the umbrella of the European Wind Energy Academy (EAWE), in order to design a training program coping with the principal R&D challenges related to wind O&M while tackling the shortage of highly-skilled professionals on this area that has been foreseen by the European Commission, the wind energy industrial sector and the academia.

The overall AWESOME research programme tackles the main research challenges in the wind O&M field identified by the European wind academic and industrial community: (1) to develop better O&M planning methodologies of wind farms for maximizing its revenue, (2) to optimise the maintenance of wind turbines by prognosis of component failures and (3) to develop new and better cost-effective strategies for Wind Energy O&M. These main goals have been divided into eleven specific objectives, which will be assigned to the fellows, for them to focus their R&D project, PhD Thesis and professional career.

The established training plan answers the challenges identified by the SET Plan Education Roadmap. Personal Development Career Plans will be tuned up for every fellow, being their accomplishment controlled by a Personal Supervisory Team. The training plan includes intra-network activities, as well as network-wide initiatives. The secondments at partner organizations and between beneficiaries are a key attribute of the training programme. Each fellow will be exposed to three different research environments from both, academic and industrial spheres.

All the network activities will be developed in accordance with the established in the Ethical Codes and Standards for research careers development, looking therefore for talent, excellence and opportunity equality.";2862074,16;2862074,16;H2020-MSCA-ITN-2014;MSCA-ITN-ETN;FUNDACION CIRCE CENTRO DE INVESTIGACION DE RECURSOS Y CONSUMOS ENERGETICOS;ES;"TECHNISCHE UNIVERSITAET MUENCHEN;CARL VON OSSIETZKY UNIVERSITAET OLDENBURG;UNIVERSIDAD DE CASTILLA - LA MANCHA;LOUGHBOROUGH UNIVERSITY;DANMARKS TEKNISKE UNIVERSITET;RAMBOLL MANAGEMENT CONSULTING GMBH;NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU;UNIVERSITY OF STRATHCLYDE";"DE;ES;UK;DK;NO"; 196564;674463;i2D;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;i2D intelligence to drive;1/05/2015;31/10/2015;;"Road Transportation represents a growing problem to be urgently solved by modern societies. More than 1 million vehicles, producing 25% of all CO2 emissions, consuming 30% of all available fossil energy and being the cause for more than 1.200.000 casualties, every year.
LiveDrive promoters, dedicated long years of R&D analyzing data driving dynamics and how to transform this raw data into valuable information. This effort was the major source to the i2D Intelligence to Drive project, a Car Telematics Platform to collect raw data from the driving dynamics, transformed into valuable information, using complex innovative algorithms, available to all potential users of the road transportation ecosystem.
The R&D stage of i2D project, co-sponsored by FAI (www.fai.pt) made proof of the basic ideas and the underline technologies, building a platform with 400 vehicles connected in 8 countries, collecting several thousand million data, processed by multiple complex innovative algorithms with special care to the area of privacy data protection.
Innovation is at the core of i2D, both from the technical side (unique electronic devices, innovative algorithms, privacy protection mechanisms and Information Systems Architecture) and the business side (concept of collect once/sell to many).
Key business areas include, major fleets (with a new wave of Advanced Fleet Management Solutions, focused in the promotion of a new Driving Behavior), the Insurance Business (the UBI Usage Based Insurance, solutions are expected to grow from more than 250 million users (USA and EU) by the end of the decade), the Local and National Authorities (to improve traffic management and safety and allow Pay How you Drive policies) to the end user the Driver, that will be the beneficiary of all road mobility improvements.
The feasibility assessment to be done during this Phase 1 is a key step for a professional approach to leverage financial resources to perform the go-to-market next stage.";71429;50000;H2020-SMEINST-1-2014;SME-1;LIVEDRIVE LDA;PT;;; 196613;642742;Enabling Excellence;SIGNED;H2020-EU.1.3.1.;MSCA-ITN-2014-ETN;H2020;Graphene-based nanomaterials for touchscreen technologies: Comprehension, Commerce and Communication;1/04/2015;31/03/2019;;"Enabling Excellence offers integral R&D training at PhD level around one of the most active and exciting topics at the forefront of nanoscience and nanotechnology, graphene-based nanostructures and materials. We propose a training experience built on three interrelated pillars, namely COMPREHENSION AND CONTROL, COMMERCE, and COMMUNICATION.
*Comprehension & Control* covers fundamental knowledge of the nano-objects, the development of functionalities and processing into macroscopic advanced materials and devices, accompanied by a broad set of characterization techniques, to understand the interrelation between local and global properties and the requirements for functional end products.
*Commerce* aims at market-ready graphene-based materials and commercial local probe Raman/AFM systems for routine quality control of graphene products. This is accompanied by innovative measures for start-up development and pitching to venture capitalists.
*Communication* is the unique keystone in Enabling Excellence. The project is a novel experiment to find how best to develop the communication skills in our ESRs, creating optimum conditions under which they are best able to flourish. The results will serve as a model adaptable to European training and research at all levels.
Enabling Excellence is formed by five partners from academic institutions and four private companies specialized in the above mentioned fields spanning TRL1-9. They offer a common and highly complementary modular structured training programme. During 468 ESR months we will address the need in Europe for nanocarbon specialists, training a new generation of highly skilled interdisciplinary clear thinking researchers. We will develop in these young people creativity, confidence and the ability to communicate with the most eminent scientists, technologists and business people. Enabling Excellence will equip them with the tools and self-belief necessary to maximize their potential in their future careers.";3358044;3358044;H2020-MSCA-ITN-2014;MSCA-ITN-ETN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;"UNIVERSIDAD DE ZARAGOZA;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;RENISHAW PLC;UNIVERSITY OF SURREY;UNIVERSITY OF SUSSEX;ETHNIKO IDRYMA EREVNON;M-SOLV LTD";"ES;UK;EL"; 196520;673635;e2CORK;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Efficient and Eco-friendly Construction Of Revolutionary surfboard blanKs;1/05/2015;30/09/2015;;"The overall objective of the e2CORK project is the construction of eco-friendly surfboard-blanks built with cork. To reach this, the design of a sustainable-industrial manufacturing procedure will be necessary.

The typical surfboards are manufactured from noxious materials and with unsustainable processes that contaminate the environment, require safety equipment for shapers exposed to toxic materials, and produce a massive carbon footprint on our planet. e2CORK will offer a clean alternative, 100% natural, organic, sustainable, and with physical, structural and mechanical properties that far exceed the current styrofoam blanks.

e2CORK will enhance the current hand-operated manufacturing procedures with a sustainable industrialization. These improvements will lead LIVING SURF to offer more competitive prices, reaching more units manufactured per day, to achieve international growth, to make a product portfolio extension and hence attaining wider audience. Moreover, e2CORK will boost the European cork-production market and its associate industries, hence contributing to the conservation of the cork-oak forests.

The specific objectives of the current phase 1 are to study and evaluate the technical feasibility as well as the sustainability and profitability of the e2CORK results. The objective of the overall innovation is that the current stage of e2CORKs TRL6 prototype version reaches a TRL9 commercial level at the end of phase 2.

LIVING SURF has a wide expertise in manufacturing and selling surfboard blanks, offering natural alternatives to existing foam products. This background and knowhow enables the company to significantly reduce the risk of undertaking the e2CORK project while maximizing the probability of success of this business opportunity.";71429;50000;H2020-SMEINST-1-2014;SME-1;LIVING SURF SL;ES;;; 196552;674109;SAFESEAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;A new generation car seat for babies;1/05/2015;31/10/2015;;"Child Restraint Systems (CRS) for the safety of children travelling by car are used in close to all cases in industrialised countries, and it is often required by law. These systems, when installed and used correctly, considerably reduce the impact of an accident on the child, thereby reducing the risk of injury and death. However, despite the extensive use of CRS, thousands of children die and many more are injured in car accidents every year. The fact that the CRS available on the market are still based on the same concept as 30 years ago, as well as the high human factor of incorrect use reducing the efficiency and safety of the system in many cases, show that there is room for considerable improvement in this field.
For several years Mobius Protection Systems has been designing and manufacturing Energy Absorbing (EA) solutions based on an innovative technology. Following successful use of the solution in army vehicles, Mobius is now looking to enter the civil market and in particular the CRS industry. By applying the Mobius technology to CRS the impact on the child during an accident can be considerably reduced, and tests have shown results which are better than leading seats available in the market today. In addition, through the SAFESEAT project Mobius aims to reduce the impact of the human factor. Both incorrect use and the possibility of forgetting the child in the car, something which has been fatal in many cases, will be addressed through a system of sensors and notifications via the smart phone of the parent. Finally the project will reduce the weight and increase strength of the CRS, by using composite materials instead of the traditional materials used, increasing safety and the comfort of the user.
During Phase 1 of the project Mobius plans to further deepen its market analysis, develop a full business plan and cost analysis, and a detailed step-by-step strategy for taking the product from the early stages where it is today, to full commercialisation.";71429;50000;H2020-SMEINST-1-2014;SME-1;MOBIUS PROTECTION SYSTEMS LTD;IL;;; 196466;672676;Neural Designer;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;A high performance solution for predictive analytics;1/05/2015;31/10/2015;;"The predictive analytics market is undergoing an impressive growth. Indeed, organizations that incorporate that technique into their daily operations not only better manage the present, but also increase the probability of future success.

Intelnics develops the professional predictive analytics solution called Neural Designer. It makes intelligent use of data by discovering complex relationships, recognizing unknown patterns, predicting actual trends or finding associations. Neural Designer out-stands in terms of functionality, usability and performance.

Current technology lacks from advanced model selection techniques, and usually requires many computational resources. The main challenge for Neural Designer is to include a framework capable of untangling complex interactions in big data sets. In order to do that, the software must achieve ultra high performance by means of more efficient algorithms, code optimization and multi-core processing.

The intended users of the solution are professional data scientists, which work at analytics departments of innovative companies, consulting firms specialized in analytics or research centres. Neural Designer will be capable of analysing bigger data sets in less time, providing our customers with results in a way previously unachievable.

The goal is to successfully market Neural Designer. The feasibility assessment of Phase 1 will help us to validate our working hypothesis regarding technical, commercial, financial and legal issues. This study will allow Intelnics to apply for Phase 2 support, in which Neural Designer will be developed to a level of global competitiveness.

The predictive analytics market is largely dominated by the United States, but completion of this project will introduce a European product in the market place of data science.";71429;50000;H2020-SMEINST-1-2014;SME-1;ARTIFICIAL INTELLIGENCE TECHNIQUES SL;ES;;; 196521;673647;Watergate;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Watergate: Development of a low-cost solar desalination technology;1/05/2015;31/10/2015;;"The Watergate project aims to bring to the market by 2017 the most competitive desalination solution for middle scale applications, a market niche accounting for 900 Million of annual investment in 2014. Its major value-added lies in the unique combination of a total independence on fossil fuel, the solution requiring only solar energy, and very competitive water costs ranging between 0.80 and 2/m3 for applications above 100m3/day.

The major innovation of Watergate lies in the fact that the whole system desalination-energy source has been redesigned, resulting in an integrated system that solves the critical issue of the low efficiency of renewable energy desalination. The value-added of Watergate relies on two pillars:
- The reduction of the size of the required solar field by more than 20% through a minimization of the energy consumption and a maximization of the energy efficiency;
- The absorption of the variations in energy intensity, making it possible to work without any complementary energy source.

The market potential for Watergate is substantial. It will not only target the current low to middle scale market accounting for 500,000 m3/day of yearly installed capacity, it will also boost the development of desalination in energy importing countries: Spain, Malta, Cyprus, Greece and Israel; as well as extend the scope of the market to users with no access to fossil fuel.

Under Phase 1 of the SME Instrument, the feasibility study will first focus on the definition of the business positioning of Cyrga. The resulting identification of the targeted segments and the relevant business model will make it possible to develop a corresponding marketing strategy and adapt the financial plan, providing the missing parts for the elaboration of a strategic business plan by September 2015. The objective for phase 2 would be to develop a real-life demonstrator, based on a prototype currently under development, which should be achieved by the second half of 2015.";71429;50000;H2020-SMEINST-1-2014;SME-1;INSOLEM;FR;;; 196480;672889;STERILISE;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Safe sustainable reliable in-office processing of medical waste;1/05/2015;31/10/2015;;"This innovation project aims to bring to technological maturity and market readiness a novel, cost effective, waste management unit - currently at Technology Readiness Level 7. Targeted specifically at the Medical Waste sector, the system has the potential to save the healthcare sector 1.2bn. By year five after project completion we plan to have generated cumulative revenues of 99m, create 90 jobs in the supply chain across Europe, and have generated a gross profit of at least 33m.

In Europe, over 1.7m tonnes of medical waste is currently produced by the Healthcare sector every year. This waste includes needles (sharps), and dressings, bandages and surgical gloves (non-sharps). Medical waste cannot be disposed of by traditional refuse collection due to its hazardous nature. The waste must be placed in separately stored special bags and/or bins, transported in a dedicated disposal vehicle and carefully disposed of at hazardous waste registered sites where the waste is either autoclaved or incinerated. This is a costly process for e.g. medical practices. At present the handling of Medical Waste puts healthcare personnel as well as cleaning staff and waste collectors at risks through extensive manual handling and storage.

The current SoA does not fully solve the problems described above and have a number of limitations. Therefore there is an urgent, unmet need for a system to reliably and safely solve the problem of handling of Medical Waste at source and provide a rapid return on investment to the customer. Our solution will give the following benefits to the end-users and Europe:
Easy and safe to use in an indoor office environment with no hazardous emission or odour;
Lower cost than existing waste collection, i.e. leasing model with a low, fixed monthly outlay, savings of at least 30%;
Eliminate the risk of contaminated waste being stored on premises for extended periods;
Simple, automatic record keeping for audit trail compliance.";71429;50000;H2020-SMEINST-1-2014;SME-1;CONVEX ELECTRICAL LTD;IE;;; 196611;642085;HISER;SIGNED;H2020-EU.3.5.4.;WASTE-3-2014;H2020;Holistic Innovative Solutions for an Efficient Recycling and Recovery of Valuable Raw Materials from Complex Construction and Demolition Waste;1/02/2015;31/01/2019;;"EU28 currently generates 461 million tons per year of ever more complex construction and demolition waste (C&DW) with average recycling rates of around 46%. There is still a significant loss of potential valuable minerals, metals and organic materials all over Europe.
The main goal of HISER project is to develop and demonstrate novel cost-effective technological and non-technological holistic solutions for a higher recovery of raw materials from ever more complex C&DW, by considering circular economy approaches throughout the building value chain (from the End-of-Life Buildings to new Buildings). The following solutions are proposed:
- Harmonized procedures complemented with an intelligent tool and a supply chain tracking system, for highly-efficient sorting at source in demolition and refurbishment works.
- Advanced sorting and recycling technologies for the production and automated quality assessment of high-purity raw materials from complex C&DW.
- Development of optimized building products (low embodied energy cements, green concretes, bricks, plasterboards and gypsum plasters, extruded composites) through the partial replacement of virgin raw materials by higher amounts of secondary high-purity raw materials recovered from complex C&DW.
These solutions will be demonstrated in demolition projects and 5 case studies across Europe. Moreover, the economic and environmental impact of the HISER solutions will be quantified, from a life cycle perspective (LCA/LCC), and policy and standards recommendations encouraging the implementation of the best solutions will be drafted.
HISER will contribute to higher levels of recovered materials from C&DW from 212 Mt in 2014, to 359 Mt in 2020 and 491 Mt by ca. 2030, on the basis of the increase in the recovery of aggregates, from 40% (169 Mt) to more than 80% (394 t) and wood, from 31% (2.4 Mt) to 55% (5 Mt);. Similarly, unlocking valuable raw materials currently not exploited is foreseen, namely some metals and emerging flows.";7665262,59;7511870;H2020-WASTE-2014-one-stage;RIA;FUNDACION TECNALIA RESEARCH & INNOVATION;ES;"BUREAU DE RECHERCHES GEOLOGIQUES ET MINIERES;SELFRAG AG;Conenor Oy;D'APPOLONIA SPA;DUMOULIN BRICKS;ADR TECHNOLOGY BV;TIIHONEN ISMO OLAVI;RINA SERVICES SPA;KNAUF GMBH;STRUKTON CIVIEL BV;SOCIEDAD PUBLICA GESTION AMBIENTAL IHOBE S.A.;UNIVERSITEIT LEIDEN;TECHNISCHE UNIVERSITEIT DELFT;MEBIN BV;CONFEDERATION NATIONALE DE LA CONSTRUCTION ASBL;ASM CENTRUM BADANI I ANALIZ RYNKU SP ZOO;Groupe Archimen;RTT STEINERT GMBH;Inashco R&D B.V;FUNDACION GAIKER;LAFARGE CENTRE DE RECHERCHE SAS;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.;ACCIONA CONSTRUCCION SA;TEKNOLOGIAN TUTKIMUSKESKUS VTT;KS LAATUENERGIA OY;Teknologian tutkimuskeskus VTT Oy";"FR;CH;FI;IT;BE;NL;DE;ES;PL"; 196549;674094;OPTILIFT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;OPTILIFT offshore lifting and logistics;1/05/2015;30/09/2015;;"The project aims to improve the efficiency and safety of offshore transportation by (1) extending the weather window for lifting operations, (2) improving the logistic planning and tracking, (3) reducing the need for floating warehouses and (4) increasing safety for offshore personnel and cargo. The solution is provided by sensor units installed at crane boom tips and dedicated software to process the data collected by these sensor units, where the concept is called the OptiLift framework. It includes three major tools, namely the logistics, human detection and crane control, to perform the improvements listed before.

The framework is significantly innovative both application and technology wise. Currently, there exists no unified solution in the market allowing extended weather windows, increased safety for offshore personnel / cargo, and improved logistic planning. Optilift framework will be first to address these industry-needs with a cost efficient and scalable application. The framework utilizes a patent pending sensor unit and cutting-edge computer-vision library to perform cargo / vessel / human detection, tracking and machine automation tasks that no other institution or company performed before.
The primary users of the framework will be the operators of offshore installations. Initially, we expect the technology to be utilized by oil and gas companies. Later, expansion into the offshore windmill farms market is envisaged.

The feasibility study will perform risk assessment for different parts of the system, determine possible technical improvements, provide in-depth analysis on potential customers in oil /gas and renewable energy industries, analyze worldwide regulatory and/or standard requirements, and perform assessments related to IPR.";71429;50000;H2020-SMEINST-1-2014;SME-1;VOCA AS;NO;;; 196482;672934;MCTDC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Multi-channel time-to-digital converter sensor with ultra high resolution;1/05/2015;31/10/2015;;"In measurements, time-to-digital converter has a fundamental importance with numerous applications. The TDC (Time-to-Digital Converter) executes an analogue-digital transformation. The input analogue value is the time delay between two signals. Whereas the output is a discreet range value, which equals the quantization of the input value. The unity of conversion or the resolution of TDC is the shortest time that changes the output value. At present, the value of this time is in picoseconds range.

The aim of this project is to create a TDC which is FPGA (field-programmable gate array) based, made of common electronic parts having many channels. Our goal is the implementation of a special complex electronic circuit whose time resolution is much better than the one of a digitally controlled FPGA. The upcoming product will provide a dynamically configured multi-channel time measuring tool, which overcomes the limitations of the prior art solutions. Its device can be produced cost efficiently, it is not sensitive to quality change and configuration stemming from mass production, and by which the absolute timing of a signal associated with an event can be measured with a high accuracy of 20 ps. MedioTrade Ltd. has already executed significant part of the innovation. We possess a functioning breadboard, which obtained promising results, moreover, both national and international patents were accepted.

The huge need and interest from the research centres and companies guarantees a flourishing partnership and significant market share for us. We expecting the rise of research activities and increasing competitiveness of Europe in the global sensor industry.

In the framework of the project, we will deepen the existing knowledge about our primary market segments, our competitors and their solutions. We will build up our Intellectual Property and marketing strategy, extensively analyse the return on investment and establish the business plan along with the financial projection.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEDIOTRADE MUSZAKI FEJLESZTO ES KERESKEDELMI KFT;HU;;; 196569;674568;DAO-BACKEND;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Validating technical assumptions for a multi-tenant mobile multiplayer game backend platform.;1/05/2015;31/07/2015;;"Daogames enables independent game developers to transform their mobile games into sustainable businesses and valuable entertainment. To achieve this we aim to provide developers with a cloud platform which enables easy integration of cloud-connectivity and multiplayer features into mobile games.The mobile games market has become the main driver of the games industry, growing to USD 22 billion worldwide revenue in 2014 with 200.000 mobile games on the market. 66% of the revenue on mobile devices is generated by games. The top performing games leverage cloud-connected features and player interaction, are operated and managed through a cloud backend and have been developed by large game studios. Independent game developers cant easily leverage these types of games because of missing technical know-how, high license and operating cost and longer time-to-market. We aim to provide independent game developers with a platform that removes these barriers, is easy to use and affordable. Indie game studios typically consist of 1-10 developers. This target group represents 99% of all mobile game developers worldwide, with a total of about 20.000 game developers (25% based in Europe). The daogames platform is unique and innovative, making previously expensive and complex technology available at low cost to the majority of this underserved market.

We verified our MVP and started a beta program in 10/2014, with a growing number of indie game developers testing our platform. Our feasibility study aims to provide concrete numbers for important assumptions used in our business plan. We'll be designing a testable small-scale representation of our production system architecture. The final outcome of this study will be the re-assurance that our chosen production system architecture fulfil technical requirements and serves as a sustainable technical foundation for our business model, thus allowing us to develop and deploy the production system in the phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;DAOGAMES GMBH;DE;;; 196602;633317;FUSION NIGHT;SIGNED;H2020-EU.1.3.5.;MSCA-NIGHT-2014;H2020;Find Your Passion for Science on Researchers Night;1/06/2014;30/11/2015;;"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences (IAR&FR), in partnership with Olsztyn School of Higher Education (OSHE) invites kids, tweens, teens and adults to join FUSION Researchers Night a unique occasion when science, entertainment and education meet in one place! Fusion Night is an incredible blend of research, innovation, fun and education that introduces young people to meet scientists who live in their city but whose work reaches across the whole world.
The FUSION Night (FN) programmes revolves around the activities that will increase the awareness of the community at large about the importance of research careers and the central role of scientists in improving the daily life and well-being of European citizens. Visitors of the FN will have a chance to join edutaining activities, become a researcher for one night and give lecture to their peers (Polish Academy of Kids), test the content of vitamins in juice or milk (Vitamins fusion or health illusion?), discover the secrets of cryopreservation in a mobile laboratory (Ice land), develop their own creams using fruit powders (Tasty skin), design a book from scratch (Night in the Library), learn the secrets of animal biodiversity (Take a walk on the wide side) or make a fruit puree in liquid nitrogen (Molecular Show of Fusion Kitchen). Sport enthusiasts can expect swimming competitions, basketball game, salsa course and martial arts training all conducted by our young researchers. We havent forgotten about the music and art lovers too, preparing for them a live concert of an international group of English teachers and an exhibition of science curiosities captured on the stained glass. Collaboration with partners from industrial circles will help to provide visitors with a first-hand view of the products and innovations born thanks to the solutions provided by science and researchers.";81000;81000;H2020-MSCA-NIGHT-2014;CSA;Instytut Rozrodu Zwierzat i Badan Zywnosci Polskiej Akademii Nauk;PL;OLSZTYNSKA SZKOLA WYZSZA IM. JOZEFA RUSIECKIEGO;PL; 196603;634135;HERCULES-2;SIGNED;H2020-EU.3.4.;MG-4.1-2014;H2020;FUEL FLEXIBLE, NEAR -ZERO EMISSIONS, ADAPTIVE PERFORMANCE MARINE ENGINE;1/05/2015;30/04/2018;;"The project HERCULES-2 is targeting at a fuel-flexible large marine engine, optimally adaptive to its operating environment.
The objectives of the HERCULES-2 project are associated to 4 areas of engine integrated R&D:
Improving fuel flexibility for seamless switching between different fuel types, including non-conventional fuels.
Formulating new materials to support high temperature component applications.
Developing adaptive control methodologies to retain performance over the powerplant lifetime.
Achieving near-zero emissions, via combined integrated aftertreatment of exhaust gases.
The HERCULES-2 is the next phase of the R&D programme HERCULES on large engine technologies, which was initiated in 2004 as a joint vision by the two major European engine manufacturer groups MAN and WARTSILA. Three consecutive projects namely HERCULES - A, -B, -C spanned the years 2004-2014. These three projects produced exceptional results and received worldwide acclaim.
The targets of HERCULES-2 build upon and surpass the targets of the previous HERCULES projects, going beyond the limits set by the regulatory authorities. By combining cutting-edge technologies, the Project overall aims at significant fuel consumption and emission reduction targets using integrated solutions, which can quickly mature into commercially available products. Focusing on the applications, the project includes several full-scale prototypes and shipboard demonstrators.
The project HERCULES-2 comprises 4 R&D Work Package Groups (WPG):
- WPG I: Fuel flexible engine
- WPG II: New Materials (Applications in engines)
- WPG III: Adaptive Powerplant for Lifetime Performance
- WPG IV: Near-Zero Emissions Engine

The consortium comprises 32 partners of which 30% are Industrial and 70% are Universities / Research Institutes. The Budget share is 63% Industry and 37% Universities.
The HERCULES-2 proposal covers with authority and in full the Work Programme scope B1 of MG.4.1-2014.";25108685,18;16813399,63;H2020-MG-2014_TwoStages;IA;NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA;EL;"HOCHSCHULE OFFENBURG;UNIVERSITA DEL SALENTO;WAERTSILA NETHERLANDS B.V.;TECHNISCHE UNIVERSITAET WIEN;LINKOPINGS UNIVERSITET;ABB Turbo Systems AG;WARTSILA IBERICA SA;FACHHOCHSCHULE NORDWESTSCHWEIZ;JOHNSON MATTHEY PLC;DINEX ECOCAT OY;TECHNISCHE UNIVERSITAET MUENCHEN;MAX PLANCK INSTITUT FUR EISENFORSCHUNG GMBH;AVENTICS GMBH;WARTSILA FINLAND OY;WINTERTHUR GAS & DIESEL AG;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;AALTO-KORKEAKOULUSAATIO;DELORO WEAR SOLUTIONS GMBH;UNIVERSITAET BREMEN;O.M.T. - OFFICINE MECCANICHE TORINO SPA;VAASAN YLIOPISTO;KARLSRUHER INSTITUT FUER TECHNOLOGIE;BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;MAN DIESEL & TURBO SE;DANMARKS TEKNISKE UNIVERSITET;POLITECNICO DI MILANO;PAUL SCHERRER INSTITUT;THE UNIVERSITY OF SHEFFIELD;LUNDS UNIVERSITET;Teknologian tutkimuskeskus VTT Oy;GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER";"DE;IT;NL;AT;SE;CH;ES;UK;FI;DK"; 196423;671952;CoMPi;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Coastal and shallow-water monitoring through innovative low-cost technologies for blue growth in the Mediterranean;1/05/2015;31/10/2015;;"Phase 1 of CoMPi aims to assess the feasibility of an innovative service on integrated coastal monitoring, with the use of low-cost autonomous observational technologies, that will allow the estimation of the future coastline displacements and the evolution of the shoreline, contributing in this way to the development of the Blue Growth Strategy.
Coastal tourism, a pillar of Blue Growth, is negatively affected by climate change in the Mediterranean and in other European coasts. Therefore, proper and sustainable management of the coasts is imperative. Although there are methods and mathematical models widely used to calculate the rates of shoreline changes, the reliability of their estimations depends directly from the amount and quality of the primary data which often have lower-than-required accuracy. For safeguarding blue growth and further developing tourism, innovative monitoring tools which use new methods and technologies for improving the quality and accuracy of the available geo-information providing thus high quality measurements of the shoreline positions are needed.
Within Phase 1, a thorough market assessment will take place as well as the technical feasibility of the business idea of PLSurveryors. The factors affecting the pricing of the service and the profitability for the company will be examined. A business plan serving as a roadmap of how the envisaged service will be further created and developed in Phase 2 for its full commercialization will be drafted.
The feasibility study will remove any bottlenecks in the ability of PLSurveyors to increase profitability through innovation and enlarge its clientele. Users of the service could be policy makers for develop tailor-made climate adaptation policies, private owners of tourist infrastructures, as well as real estate sectors of banks and insurance companies that shall be able to outline the threats on the coastal area and therefore calculate the potential risks of future tourism investments.";71429;50000;H2020-SMEINST-1-2014;SME-1;LAMPROU D PETRELIS N GP;EL;;; 196505;673436;NIRIS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Non-Intrusive Resident Identification Sensor;1/06/2015;30/11/2015;;"The goal of Non-Intrusive Resident Identification Sensor (NIRIS) project is to introduce the first affordable NIRIS to the market, which is the key component to enable true intelligence in smart buildings. Currently available smart buildings rely on user input and manual micromanagement to function correctly, which is neither efficient nor user friendly. Our sensor, on the other hand, non-intrusively identifies users passing through a doorway, which enables automatic adaptation and optimization of house appliances management, i.e. true smart buildings.

Moreover, an array of NIRIS sensors can monitor users room-level location and detect anomalies, increasing safety and security of inhabitants and enabling a range of new applications, e.g. tele-medicine. Artificial intelligence method embedded in our NIRIS (developed in E-doorman project) accurately predicts users room-level location based on past behaviour. User-presence prediction can be used to lower households running costs by up to 30% and at the same time increase comfort of inhabitants. This means more than 300 in savings for an average European household per year. We intend to sell our sensor for less than 50 per unit, at an average of 3 sensors per house; this means that consumers payback period will be less than 6 months.

All required intellectual property rights (IPR) are owned by Elgoline or are in public domain; the most important IPR is already protected by a patent filed on July 30th 2014 at the Slovenian patent office. Within the NIRIS project we will analyse opportunities for sensor applications, elaborate on business plan and connect with appropriate partners to bring NIRIS to the masses.";71429;50000;H2020-SMEINST-1-2014;SME-1;ELGOLINE DOO;SI;;; 196600;633162;WeForYou;SIGNED;H2020-EU.1.3.5.;MSCA-NIGHT-2014;H2020;Meet and learn What Excellent science does FOR YOU and the society;1/04/2014;30/09/2015;;"Meet and learn What Excellent science does FOR YOU and the society is the major focus of the coordinated WeForYou action in performing the European Researchers Night 2014 and 2015 in Slovenia. Energy research & innovation, Environment & Climate Action, Health and ICT Research & Innovation are the priorities which will be tackled by a series of actions and opportunities for interchange of knowledge in the European Researchers Night 2014 and 2015 in Slovenia.

The events in 2014 and 2015 in Slovenia will take place in:
- Ljubljana, the main city square organized by Jo?ef Stefan Institute (JSI);
- Novo mesto, organized by Faculty of Information Studies;
- Piran and Piran bay, organized by National Institute of Biology;
- Planica, Planetary Habitat Simulation Centre organised by JSI;
- Kr?ko, organized by Jo?ef Stefan Institute (JSI)

The European Researchers' Night aims to bring researchers to the general public and to increase awareness of research and innovation activities, with a view to support the public recognition of researchers, creating an understanding of the impact of researchers' work on citizen's daily life, and encouraging young people to embark on scientific careers. Among the goals of WeForYou is one of special importance - presenting the researchers that have shown excellency in their results and achievement as ordinary people. Activities that are planned will enable the wide public audience to identify itself with the researchers life and to promote science in a firm expectation that the passed message to the young people will embark them on scientific careers. Children and adults addressed within the WeForYou activities will have the opportunity to understand science by experiencing its day-to-day practices, by frequenting the spaces and places where research is carried out and by coming into contact with its machinery and equipment, but above all by talking to those directly involved in scientific research that brings benefit to the society.";79737,5;71765;H2020-MSCA-NIGHT-2014;CSA;INSTITUT JOZEF STEFAN;SI;;; 196506;673467;Lipid;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;"The untapped potential of omega-3; from fish oil to healthy bowels";1/05/2015;31/10/2015;;"Europe's consumers are increasingly requesting products that are organically and sustainably produced. At the same time, Europe has been lacking incentives to develop and bring to markets new marine products, without increasing pressure on natural resources.

The innovation in question; a natural, sustainably produced medicine based on marine oils, addresses these challenges. It is based on the discovery that omega-3 oils have proven to have laxative effects. It offers parents and pediatricians a pain-free alternative to other pharmaceutical products, in a market where no new products have been introduced for decades. The innovation also paves the way for the full utilization of marine products, demonstrating that by-products can be of high value for other industries, including the pharmaceutical sector.

The aim of the applicant is to develop this innovation all the way towards a market-ready, licensed pharmaceutical product. The pharmaceutical industry is one of the largest industries in the world in regards to revenues. Over 100 million people worldwide, suffer from constipation. The active ingredient of the innovation product would be a new and a unique addition to this growing market.

The applicant seeks support to be able to obtain a solid analysis of the market potential for the innovation. If successfully brought to markets, it will reach the milestone of being the first non-generic, registered drug, tested in clinical trials in humans that was discovered, developed and produced in one of Europe's most peripheral corners, Iceland.";71429;50000;H2020-SMEINST-1-2014;SME-1;LIPID PHARMACEUTICALS EHF;IS;;; 196465;672655;AgriCloud;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Demonstration of a cloud-based precision farming management system for a sustainable and intensive agriculture to secure long-term food supply in Europe;1/05/2015;30/09/2015;;"The project intends to commercialize an integrated precision farming service model in the cloud to increase farming productivity and profitability in a sustainable way. Today, the majority of farmers manage their crop by gut feeling, leading to inappropriate fertilization, plant damage and unnecessary environmental impact. The AgriCloud system is the first holistic management approach, processing all available data from agronomic sensors, machinery and service companies and, backed by plant nutrition expert knowledge, will facilitate a targeted use of fertilisers and herbicides, efficient machinery utilisation and workflow management.
AgriCloud will increase yield production between 3-10%, reduce lodging to 50-100%, reduce fertilisers by 12-20% and improve harvest efficiency by 12-20%. Farmers total annual savings amount to approx. 130/ha, so that their pay-back time, dependent on the total arable land, is about 1.5-3 years. The estimated market potential for Agricon is about 28 Mill. in 2021.
Farmers are operating a mixed stock of stand-alone agricultural machinery. AgriCloud meets their need for integrated solutions with only one data infrastructure for a coordinated, easy-to-use machinery control from one user interface that informs on the causalities and determinants of yield.
The feasibility study comprises an investigation of market structures, segments and barriers, specifically of international markets, a customer survey, the identification of 7 pilot customers and development of an IP strategy. Technical goals are an customer-oriented specification and revision, risk analysis and consideration of regional characteristics.
AgriCloud helps maintain Europes agricultural competitiveness and sustainability and manage climate change adaptation to ensure long-term food security and food quality. AgriCloud also contributes to implement the recent EU Common Agriculture Policy (CAP).";71429;50000;H2020-SMEINST-1-2014;SME-1;AGRI CON GMBH PRECISION FARMING COMPANY;DE;;; 196601;633563;NCP ACADEMY;SIGNED;H2020-EU.5.f.;GARRI-8-2014;H2020;National Contact Points for quality standards and horizontal issues;10/12/2014;9/12/2017;;"National Contact Points (NCPs) will play a key role in Horizon 2020 as providers of information and assistance to potential applicants and project beneficiaries. They constitute the main interface to the European R&D community for Member States and Associated Countries and the European Commission. While their activities are underpinned by the European Commissions Guiding principles for setting up systems of national contact points, NCPs are appointed and financed at national level so that existing NCP systems show a wide variety of architectures and ways of working.

This project aims to create and implement a new and integrated training of Horizon 2020 advisors the NCP Academy. It brings together NCP Coordinators and NCPs for Legal and Financial aspects of Horizon 2020 to develop the NCP Academy concept and to develop and implement training courses on cross-cutting issues. It addresses quality standards and good practice as well as routes to feedback and communication for this community. In doing so it aims to significantly enhance the performance of NCPs and does so by harnessing the knowledge base already existing within this community.

It will be responsive, addressing new issues that emerge during implementation of the Horizon 2020 programme and it will be all-inclusive, providing training to all NCPs, and especially targeting new and/or less experienced NCPs. The consortium will work closely with existing thematic NCP Networks, carefully serving their needs for cross-cutting aspects of Horizon 2020.

Expected impacts include achievement of an improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls.";1967828;1967828;H2020-GARRI-NCP-2014-1;CSA;ENTERPRISE IRELAND;IE;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;INNOVAATIORAHOITUSKESKUS TEKES;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;INSTITUTO DE SALUD CARLOS III;STYRELSEN FOR FORSKNING OG UDDANNELSE;TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY;AGENCE BRUXELLOISE POUR L'ENTREPRISE;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;CENTRUL PROIECTE INTERNATIONALE;MINISTERE DE L'EDUCATION NATIONALE, DE L'ENSEIGNEMENT SUPERIEUR ET DE LA RECHERCHE;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;VEREIN EURESEARCH;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"DE;FI;AT;ES;DK;CZ;BE;EL;PL;MD;FR;HR;CH;IT;PT"; 196537;673878;FIBGLOW;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;High insulating fiberglass window and curtain wall profiles;1/05/2015;31/08/2015;;"Windows and curtain wall profiles are responsible for about 30-50% of the heat loss through typical building envelopes. The material used to produce the frame plays a prominent role not only in terms of energy-efficiency but also regarding the behaviour of the product when expose to fire.
FIBGLOW project consists in the designing, industrialization and commercialization of fiberglass-based window and curtain wall profiles, which are not extended in the European market. FIBGLOW is the best substitute to current aluminium, wood and PVC materials providing unique thermal insulation values, outstanding mechanical properties, fire-resistance performance, maintenance-free and magnificient durability.
FIBGLOW will help construction companies and installer to comply with the most stringent regulation in terms of energy efficiency (Directive 2010/31/EU - Nearly-zero energy buildings by 2020 and 2018 for Public buildings) and fire resistance (Euroclass classification according to CPR EU 305/2011).";71429;50000;H2020-SMEINST-1-2014;SME-1;GUALINI SPA;IT;;; 196451;672583;SmartComm-LED;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Reconfigurable silicon architecture for connected intelligent lighting.;1/05/2015;30/09/2015;;"Lighting accounts for 19% of energy consumption in the developed world. However low energy lighting technologies are rapidly replacing the traditional incandescent technology and by far the most rapidly growing low energy lighting technology today is LED. The LED lighting market was worth $16.5B in 2013, is growing at a CAGR in excess of 16% and is projected to continue growing at this rate through to 2018 when the market is projected to be worth $33.5B.

Not only is lighting moving towards more energy efficient technologies such as LED, but the way in which lighting is used is also undergoing a dramatic evolution. Lighting is becoming increasingly connected and increasingly intelligent and it is this growing market that Ikon Semiconductor aims to address with this proposal.

The target customers for the outcome of this project are manufacturers of LED lighting power supply systems. The project aims to develop an optimum re-configurable silicon architecture for connected intelligent lighting systems for use in smart buildings including residential, commercial and industrial. It will enable a single highly configurable chip-set solution with an optimum hardware/software co-design to operate with any wireless or wired communications protocol and will allow the developers of advanced lighting power supply systems to re-configure their design to address a broad range of applications. This will replace the currently available disparate range of fixed-function solutions and will enable reduced cost and time-to-market for our target customers. Such a solution has global commercial potential.

In this Phase-1 SME instrument feasibility study we aim to use both new and existing end-user advisor relationships to carry out a market validation and an economic viability analysis. It is also our intention to submit a business plan for a Phase 2 SME Instrument during 2015.";71429;50000;H2020-SMEINST-1-2014;SME-1;IKON SEMICONDUCTOR LIMITED;IE;;; 196531;673712;DAM Component;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Dual Active Mode Component;1/05/2015;31/08/2015;;Dual Active Mode (DAM) Component project consists in the designing, industrialization and commercialization of a Smart Product (passive sensors or Internet of Things, IoT) embedded into an innovative sandwich-like structure for interior furnishing of Recreational Venicles (RV) and yachts manufacturing industries as well as other potential sectors such as trains and vessels. DAM Component will provide reduction in environmental impacts due to its unique lightness and improved resistant properties as well as added values for final customers because of incorporated digital functionalities which will offer a much more comfortable environment and sophisticated systems to reduce maintenance-cost.;71429;50000;H2020-SMEINST-1-2014;SME-1;TECNOFORM SPA;IT;;; 196467;672657;Gamesmondo;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Gamesmondo Affiliation and Monetisation Ecosystem;1/05/2015;31/08/2015;;"Flexion Mobile is a leading Android games monetisation service provider whose unique enabling products let developers and publishers monetise games outside Google Play. The Gamesmondo project, currently in TRL 6, is a major part of Flexions long-term strategy to become the first choice for Android game distribution outside Google Play, capture at least 100 million Monthly Active Users (MAU) with a target revenue of 25-35m EUR.
Gamesmondo targets the Android segment of the mobile games market - a market which as a whole is forecast to be worth $41 billion in 2017 and is forecast to surpass the console market in terms of revenues in 2015. Market growth will be driven by emerging mobile markets.
Google Play is the dominant store on the Android ecosystem, but there are also hundreds of stores (3rd party, OEM and operator stores) as well as Android devices without Google services with strong user bases who should be valuable parts of the games ecosystem. Technical and commercial fragmentation combined with Googles dominating position within games distribution and search means the ecosystem outside Google Play is struggling, while the space within Google Play is becoming increasingly monopolised.

Gamesmondo uses enabling technology and commercial relationships to create an aggregated network of games, stores and users. This makes the world outside Google Play viable. Developers get access to stores otherwise unreachable. Stores get access to games otherwise unavailable. Users benefit from increased competition and choice. Flexions core enabling products create seamless enabling with market-specific monetization and ancillary features without requiring resource intensive work for developers or stores.
The Gamesmondo ecosystem will define a new set of tools, rules and methods for both developers and end users, whilst building a versatile foundation for benefiting from a growing market and successfully shrinking inequality by Google Play.";71429;50000;H2020-SMEINST-1-2014;SME-1;FLEXION MOBILE LIMITED;UK;;; 196469;672723;USODA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Upscaling Synthesis of Ordered mesoporous silica material for Drug delivery Applications;1/06/2015;30/11/2015;;FORMAC Pharmaceuticals NV is actively developing and commercialising an innovative and proprietary drug delivery technology to increase the oral bioavailability of poorly aqueous soluble drugs. Those molecules represent up to seventy percent of the compounds in discovery pipelines and up to forty percent of the currently marketed drugs. Based on the use of Ordered Mesoporous Silica (OMS) materials, FORMACs platform enables clients molecules to be formulated as oral drug products for early development, life cycle management or generic development. FORMAC is key leader in this emerging field with more than twenty different collaboration agreements and fifty molecules tested. Together with its validation in a human clinical setting, numerous regulatory consultations on EU level have been conducted. FORMAC is now ready to secure its first licensing deal with a pharmaceutical or generic company. However, some remaining challenges are hampering full deployment of FORMACs technology platform. Given its development stage, the company is still facing (i) an unfavourable cost of goods profile linked to the current OMS synthesis process and (ii) its limited manufacturing scale. The current proposal will unlock the first limitation and create possibilities for further upscaling. FORMACs ultimate goal is to bring OMS based drug delivery to the global market.;71429;50000;H2020-SMEINST-1-2014;SME-1;FORMAC PHARMACEUTICALS NV;BE;;; 196561;674335;iDriver;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;iDriver;1/06/2015;30/11/2015;;Intelligent wireless Driver for outdoor LED lighting application;71429;50000;H2020-SMEINST-1-2014;SME-1;TVILIGHT B.V.;NL;;; 196563;674455;GReen Desalination;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;GReen Desalination: A closed-loop technology for full recovery of water and raw materials from the wastewater effluent;1/05/2015;31/10/2015;;"GReen Desalination Project aims to deliver a well-proven concept to the water and salt markets. The desalination process involves a lot of wastewater that is currently discharged into water bodies, causing environmental degradation, while its energy and resources content goes wasted. These raw materials are leaking today from our economies and can create significant business opportunities, both in and outside EU.
SOL-BRINE system comprises an advanced technology that can: (a) provide a near-market solution to the complex issue of sustainable brine handling, (b) improve the efficiency and overall costs of desalination; and (c) recover raw materials. The proof of concept was demonstrated successfully through the development of a pilot system within the European project with the acronym SOL-BRINE. It managed to prove the concept of Zero Liquid Discharge and full resource recovery (water and salt) from desalination brine. The pilot system has been tested thoroughly and the developed technology has reached high readiness level (TRL = 6). The European funding will be utilized for elaborating the feasibility study and an investable business plan for applying this eco-innovation to end-users in industry, tourism, municipalities etc. The feasibility study has the following objectives: To verify market readiness of this eco-innovative water solution To get a clear picture of the target market and identify the market segment that is ready to buy this technology; To assess market readiness in terms of receptiveness of our technology; To explore and assess the commercial potential of this breakthrough idea To make a competitive analysis To estimate cash flow, income and expenses, break-even points To produce a growth plan To determine key economic data such as ROI (Return On Investment) To develop a go-to market strategy that will enable the wider deployment of desalination, by addressing effectively environmental impacts and restriction.";71429;50000;H2020-SMEINST-1-2014;SME-1;AEPHORIA NETWORK PC;EL;;; 196554;674167;HIQ-Home;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Advanced System for Eco, Energy and Cost Efficient, Comfortable and Secure Smart Homes;1/05/2015;31/10/2015;;"Current smart homes are not as smart and user-friendly as promoted. They enable household monitoring and appliance control with several new HW and SW solutions and extensive manuals, but do not automatically adapt to the users living habits. Moreover, studies showed that smart home schedules set by the users are widely inefficient thus contributing to excessive energy usage. Initial tests show that up to 33% of energy saving can be achieved with our innovative approach.
The presented product tries to breach the gap between the users and a truly smart home by introducing an on-demand cloud service that implements multi-criteria optimization and dynamic user profiling methods in order to optimize performance in any smart building and in particular connected into a smart city. Moreover, the user can only qualitatively set a couple of parameters and then select one of the control strategies proposed by the system, dealing with balance of energy preserving, comfort and security. Optimization methods achieve even higher energy savings with alternative energy sources, e.g., photovoltaic energy. The technological feasibility of the project was already verified on a small house prototype.
The market potential for the presented service is extremely high, with the revenue growth estimated to reach $51.77 billion by 2020, at an estimated CAGR of 29.5%. Several key players like Google are entering the market indicating another global dominance. We are in contact with several global market providers to speed-up the commercialization of our product.
During the feasibility study we will mainly focus on market analysis, user needs, the range of provided services and functionalities, and the pricing mechanisms. Additional technology verification for a large scale application will be conducted and the need for cooperation with third-party institutions will be assessed. The important result of the study will be the feasibility report that includes a detailed business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;ROBOTINA D.O.O., PODJETJE ZA INZ ENIRING, MARKETING, TRGOVINO IN PROIZVODNJO;SI;;; 196490;673107;LESS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Lift Energy Saving System for Residential Buildings (LESS);1/05/2015;31/07/2015;;"The global objective of this project is to develop, test and industrialize a low-cost system that captures energy from lifts and other renewable energy sources to intelligently store, reuse and supply energy to power residential buildings using ultracapacitors and batteries. This industry-demanded and market-driven Lift Energy Saving System (LESS) champions EU smart energy efficiency policies and empowers European electricity consumers to take charge of energy costs and consumption.
Our general objective can be further developed in the next three sub-systems:
- Product development and production of a low-cost energy recovery system.
- A Hybrid energy storage systems with ultracapacitors and batteries that enable autonomous operation of the microgrid system.
- Connector elements to add versatility to the system (so that other sources of micro generated energy such as solar panels or micro wind generators could simply be installed in buildings).
As stated above this project has a big target market. Around 4.5 million lifts are currently installed in the EU. The remaining 3.2 million are medium-use elevators (found in our target residential sector) where the innovation proposed could be disruptive. This means that the new development has a target market of about 2.1M lifts in Europe. This includes only the existing lifts. According from the Elevator World Magazine, 12,000 new electric lifts were installed in Europe, representing a 10.7% increase on 2011. Although we are targeting Europe first with our technology, we believe this technology could also be marketed at the international market.
Our overall objective for Phase 1 is to create a Feasibility Study that consists of a technological feasibility, market assessment, business model assessment, risk assessment, IPR assessment and a Business Plan. If the result of the Feasibility Study is positive, we will apply to Phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;EPIC POWER CONVERTERS SL;ES;;; 196523;673770;DWT-I4FEDW;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;DWT- Impregnation for Fireproof Excellent Durability Wood;1/06/2015;30/11/2015;;"DWT-I4FEDW aims to develop an innovative technological process that produce a new structural engineered material (FEDW), having higher yields compared with the best alternatives in terms of technical results, economic and environmental footprint performances. That would make FEDW advantageous competitor and feasible alternative as structural fireproof material in constructions area, representing the best performing wooden material for supporting structure. The innovation refers both to:
a) FEDW an extremely innovative treated wood having outstanding properties of fire resistance and durability; it is obtained by impregnation, till the core of timber, by using electro magnetic waves technology. The outcome is represented by a semi-finished ecological new wooden material having the highest fireproof and durability characteristics, sensibly improved hardness.
b) DWT-I process is the innovative and ecologically-friendly system for impregnating wood of different species with different preservative liquids. Its most important characteristics are:
a) the first system for full impregnation of timber, instead of only superficial;
b) impregnation process can be made both by using different fire-proof & durability chemical liquids;
c) very economic: the technology can easy installed on existing impregnation factories retrofitting the existing plants;
d) can treat several wood species and use different liquid to fit customised purposes.
e) improve the efficiency of existing impregnation processes
DWT-Process process ameliorates properties and service life performance of cladding, panelling, decking, fire safety doors, outdoor furniture, garden infrastructure, Marina, and structural elements.
Upon successful completion of this project, likely benefits to society will include:
Availability of FEDW constructional fireproof components and with long durability
Local grown timber species opposite imported;
100% non-toxic wood playgrounds
100% non-toxic wood with ground";71429;50000;H2020-SMEINST-1-2014;SME-1;DANISH WOOD TECHNOLOGY AS;DK;;; 196408;666758;ADR1EN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-2;H2020;First European System for Active Debris Removal with Nets;1/04/2015;30/09/2017;;"STAM, SKA and OptiNav are three high-tech SMEs, that have developed and validate till TRL 6 a system for active debris removal with nets, through an ESA contract (4000109361/13/NL/RA) within the Clean Space initiative.
ADR1EN aims at the business opportunity generated by the need to increase safety of space infrastructures, which are menaced by the huge number of space debris lost in space. In line with our product/service roadmap and the short to medium term market needs identified by the detailed Business Plan elaborated, we have identified the SME Instrument as the most valuable tool to support the financial risks involved in addressing the remaining technical and non-technical barriers to market. The objective of the project is to validate by testing and qualify for space a scaled-up demonstrator of the First European System for Active Debris Removal with Nets (ADR1EN) and develop the necessary business and commercialisation plans to reach the market and boost the growth of our companies. The system will be pushed to TRL 7 to show its applicability to real cases and to confirm that ADR1EN is the cheapest and most reliable system for capturing free objects in space.
As a result, in line with the priorities set by ESA and NASA, the system will be cost-effectively used by a community of users, namely Thales-Alenia Space, GMV and Airbus, to catch large debris in Low Earth Orbit region, representing a market worthwhile 450 MEuro, associated with the currently mapped 5,000 defunct satellites and related debris.
Thales-Alenia Space, one of the largest industrial players in the space industry, has expressed its interest in the system and will act as subcontractor, to complement our capabilities and facilities. Their role is fundamental to ensure that we keep the full control of IPR while involving a potential first user in the project, keeping maximum flexibility to sell or license the technology in the next commercialisation stage.";1730000;1211000;H2020-SMEINST-2-2014;SME-2;STAM SRL;IT;"OPTINAV SP ZOO;SKA POLSKA SP (ZOO);STAMTECH SRL";"PL;IT"; 196559;674321;Project NGR M;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Market Entry Feasibility Project for Next Generation Rubber;1/05/2015;31/08/2015;;Through participation in the Horizon 2020 SME instrument Phase 1 project, Rubber Products Ltd hopes to receive funding in order to continue development and commercialization of their new rubber technology (Next Generation Rubber, hereafter NGR). The objective of the project is to develop a market entry feasibility study for NGR and NGR compounds commercialization that would include an thorough analysis of market needs, including recipes, and a business plan with an extensive sales strategy. The feasibility study will: (1) identify potential customer needs in terms of quality and tailor recipes to suit those needs (2) define target market and its size and map potential customers (3) define NGR and NGR compounds sales strategy and create detailed sales models. In an industry that has seen sustained growth on the world stage, the use of NGR in the production of rubber products will limit the need for other resources, namely natural and synthetic rubber, allow for recycled rubber to be used in high value added rubber products, and reduce the negative environmental impact related to the production of natural and synthetic rubber. NGR and NGR compounds will be usable as partial substitutes for other raw materials across the rubber goods industry, but they will be particularly impactful to the tire manufacturing industry. The tire manufacturing industry is the largest consumer of raw rubber material and the producer of rubber materials in the world. NGR products offer producers a competitive advantage by reducing price of production, while also allowing for recycled rubber products to be reused instead adding to the already large amount of rubber waste. Bringing NGR products to the market, will also help achieve the European Innovation Union initiative for smart, sustainable, and inclusive growth.;71429;50000;H2020-SMEINST-1-2014;SME-1;SIA RUBBER PRODUCTS;LV;;; 196491;673155;LeakFree;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Development of a reliable quality control system using advanced Non-Destructive Evaluation (NDE) technologies for the production environment of leak-free fuel tanks from plastics and composites;1/06/2015;31/03/2017;;"Nowadays, the usage of Plastic Fuel Tanks (PFTs) has dominated over steel tanks as they offer numerous advantages such as lower weight, higher corrosion resistance, better crash performance and lower total systems costs. Tank manufacturing from plastics and composites in automotive sector is increasingly adapted to mass productions to meet the ever growing demand. The management of quality control (QC) systems for factory environment poses challenges in the absence of relevant experience in the development and use of in-situ non-destructive evaluation (NDE) technologies.
The problem currently faced by the automotive industry is that most techniques that fall within the accepted leak detection sensitivity requirements are based on manual intensive and operator-dependent tasks. Leak detection techniques with higher sensitivity do exist; however they are characterized by high investment and operational costs. Hence, their implementation is not economically feasible as the related costs outweigh their benefits for the automotive QC purposes.
The LeakFree project targets at bringing to the market a low cost leak detection system that is fast, accurate, traceable and automated for mass production environments in the fuel tanks production industry. The system eliminates the disadvantages associated with the manual-intensive and operator-dependent techniques, currently employed by the industry, through the development of an inspection technique based on Acoustic Emission (AE). The LeakFree acoustic technology has already been demonstrated in fuel-tank production environment and the project targets at bringing the system to the market. The activities to be performed span from design and prototyping to validation, demonstration, performance verification and standards certification. Additionally, efforts will be placed at connecting the LeakFree product to the Enterprise Resource Planning (ERP) system of the rotomolding production company.";1196286,75;837400,73;H2020-SMEINST-2-2014;SME-2;FLOTEKS PLASTIK SANAYI VE TICARET AS;TR;;; 196522;673810;OSS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;OpenSMESearch (OSS);1/05/2015;30/09/2015;;"'OSS (OpenSMESearch) aims to provide a platform to the online visibility problem facing by millions of micro SMEs in Europe. Despite they are regarded as the backbone of the European economy, important source for jobs, SMEs are losing online visibility with massive explosion of big data in the Internet era. This phenomenon is caused by two main factors: 1) more than 40% do not have a website yet and 2) they are not transparently shown in web searches, as the order of results is influenced by optimized, sponsored and paid business results. Therefore, small local businesses are suffering clear erosion in their individual sales, taxable sales for government revenue, which is based on local consumers (B2C) and services to other business (B2B). This problem is of vital relevance for the EU.

OSS is our future flagship product based on pool of public and private data. OSS will be a dedicated search ecosystem for European SMEs, will provide transparent, relevant and global online visibility, facilitating the matching of business to consumers (B2C) and business to businesses (B2B), eliminating any disintermediations. OSS is crowd sourcing, ads free search model coupled with semantic database technologies built on the combination of both open and our private data sources. This product also has potential to extract commercial value from open data and increase private data profitability.

The goal of OSS is to make local micro, SME knowledge globally visible in big data internet world. In this line, we present an analogy of our ambition. Wallet verses internet analogy: Big companies are like 'Bank cards & bills' where as micro SMEs are like 'coins'. Most of the wallets are not having provision for coins likewise SME results are not getting enough visibility on global search platforms. Therefore, our aim is to be as a 'SME source for global search engines (our existing clients)' (wallet: cards\coins) and at the same time as a 'dedicated SME search platform' (just as a coin pocket wallets). The idea behind this project is to make OSS a global success, able to revolutionize the online visibility and search for SMEs, while allows us penetrate into the BIG DATA market, which is skyrocketing at a 35% CAGR.

OSS is for the people by the people and to the people to make European SME local knowledge globally available.'";71429;50000;H2020-SMEINST-1-2014;SME-1;DATACENTRIC PDM SA;ES;;; 196450;672506;PASSIONATE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Providing Active Safety Shoes based On Nano Technologies;1/06/2015;30/11/2015;;"Nano-technologies and other material science innovations have yielded a range of materials with highly functional surface properties. Some of these materials are available in the form of films or foils (2D sheets). Bekina Boots (a global leader in polyurethane protective footwear) has patented technology for producing safety footwear in foamed plastic with an additional protective outer layer. Bekina Boots wants to integrate these hi-tech foils onto footwear, in order to enable a radically new form of active personal protection in a wide range of niche applications. Footwear which senses and/or actively interacts with its environment can deliver an unprecedented degree of protection to workers worldwide. This innovation has the potential to become the new standard for safety footwear in a number of industries and is disruptive to current footwear which typically provides passive protection based on a physical barrier.

The main objectives of the study relate to the economic feasibility and production upscaling:
- The exploration of potential niche applications and assessment of their market potential
- Development of an operational framework (incl. technology & commercial partnerships) to roll out a global marketing & commercialization strategy.
- Development of a detailed business & financial plan so that Bekina Boots can capture the market.";71429;50000;H2020-SMEINST-1-2014;SME-1;BEKINA BOOTS NV;BE;;; 196436;672221;HEATSENS_S;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Lab-on-a-chip microfluidic device based on plasmonicdriven thermal sensing for rapid detection of Salmonella typhimurium in agro-food field.;1/05/2015;31/10/2015;;"NANOIMMUNOTECH (NIT), a leading company in nanobiotechnology with know-how that has been applied to the field of nanobiosensing and especially the agro-food sector introduces HEATSENS in the poultry industry: a solution that transforms into a portable and easy-to-use device with its most cutting-edge know-how in biosensors.
HEATSENS is based on a revolutionary nanobiosensing technology owned by the company, whose main characteristics (highly sensitive, rapid detection and simplicity) are the ideal response to a clear need in this sector to test for Salmonella.
Salmonella is the second most commonly reported gastrointestinal infection, requiring hospitalisation in many cases, and it can be fatal. One of the most common ways of contracting it is by eating contaminated chicken meat; thus meat companies are required to carry out periodic tests, for which they send samples to specialist laboratories that have a response time of up to 7 days for the analyses, which may mean financial losses.
Given that this technology fits into the NIT development strategy, it was decided to perform proofs of concept with several companies in the sector, which clearly showed that HEATSENS_S detects Salmonella at a higher sensitivity in only 3 hours. In light of these results, these potential customers have already shown their keen interest in HEATSENS_S.
Now, its conversion into an easy-to-use portable device makes performing in-house testing possible throughout the production chain, providing companies with greater control over product quality and avoiding losses associated with contamination not detected in time, all at a lower cost than current tests today.
NIT Management considers this to be the optimum catalyst for the growth of the company and its expansion worldwide and HEATSENS, the flagship product, to make their efforts profitable in nanobiosensing.";71429;50000;H2020-SMEINST-1-2014;SME-1;NANOIMMUNOTECH SL;ES;;; 196452;672586;FACTs;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Fast Acting Virus Control Strategies for Production Animal Diseases;1/05/2015;31/10/2015;;"The objective of the FACTs project is to sign a term sheet with investors for ViroVet, an emerging Belgian biotech company, aimed at developing and introducing a disruptive treatment for bovine viral diarrhoea (BVD) in beef cattle.
BVD is a globally endemic disease of cattle costing the industry billions of Euros every year in the form of increased mortality, decreased feed efficiency and increased susceptibility to secondary disease. Conventional BVD vaccines are unable to fully control the disease due to antigenic variability of the virus and inadequate host immune response to vaccination. BVD virus can infect calves in utero leading to persistently infected (PI) animals that are difficult to detect but that shed massive amounts of virus, resulting in continuous contamination of the herd. The product will initially be launched in the EU and US, with other large beef-producing markets, such as Brazil, also considered. It will be administered to cattle upon arrival at the feedlot or auction house, which is a time of high susceptibility to infection. The drug will prevent exposed animals from developing clinical disease and will reduce viral shedding by PI animals until they are identified and separated from the herd. The drug will be added to standard processing procedures to minimize labour time and cost.
The BVD project is in TRL-6 stage and is predicted to reach market in 6-8 years time with peak sales of 150 million in the EU and US alone. Key opinion leaders (KOLs) are supportive of the product and a number of investors have expressed their interest. In Phase I, ViroVet will conduct market research and consult with KOLs in Europe and in other major beef markets to ensure successful introduction of the product. A comparative analysis of regulatory requirements will assist in the refinement of the business plan that will minimize time to market and maximize rapid return on investment. Contracts with investors will be finalized and a term sheet will be signed.";71429;50000;H2020-SMEINST-1-2014;SME-1;ARATANA THERAPEUTICS NV;BE;;; 196519;673607;SmartGridEnable;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;SmartGrid Distributed Monitoring, Synchronization and Active Management;1/04/2015;30/09/2015;;"A critical challenge for smart grid ecosystems is to optimise the ROI for Utilities. SmartGridEnable will addresses this by creating product solutions to help Power Utility Distribution Network Operators (DNOs) achieve their carbon reduction targets by enabling them to better manage their network in support of lower carbon footprint technologies & new energy generation business models from green energy renewable sources.
Using patented current/voltage sensing technology MAC has identified two business opportunities that will greatly assist DNOs in the management of their Low Voltage (LV) & Medium Voltage (MV) Distribution networks. These include; (a) the development of a LV Network Monitoring System to support Demand Response Management Systems (DRMS). This solution will directly feed into & support DRMS currently being put in place by all DNOs for better network management of lower carbon footprint technologies, such as e-cars & renewable energy generation on their networks. (b) development of a cost effective Phasor Measurement Unit (PMU) for mass deployment, that will help DNOs avoid grid instabilities, & monitor generators response to abnormal deviations in system frequency due to load variations & renewable energy connections.
Mass deployment will also enable DNOs facilitate lower tariff offers on renewable energy generation to customers when peak supplies such as wind is available, thus reducing existing power plant outputs. The solution will assist European DNOs achieve their 2020 carbon reduction targets & be carbon neutral by 2050, reducing networks outages duration & customer losses by 20%, & improving overall management of the distribution grid by 15%.
SmartGridEnable uses patented sensing technology that was developed for fault monitoring on MV neutral compensated networks. This technology could address the lucrative LV & MV network monitoring market but requires detailed investigation & business planning to bring this technology to market.";71429;50000;H2020-SMEINST-1-2014;SME-1;THE NATIONAL MICROELECTRONICS APPLICATIONS CENTRE LTD;IE;;; 196454;672596;algaPLUS;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Upscale and optimisation of an olive wastewater treatment photobioreactor (PBR) coupled to algae biomass valorisation as biofertilizer and treated water reuse;1/05/2015;30/09/2015;;"Olive oil production uses considerable volumes of water (50L/100kg olives) in European Mediterranean countries where this resource is scarce (Spain, Italy and Greece). The processes used by this sector leads to significant wastewater containing phenols and polyphenols. The EU Legal Framework sets the need of an efficient solution that reduces water use, improves water quality and recycle the waste produced. However the benefit margin of olive oil producers is very low, making production without support uneconomic for farmers. As yet, there are no cost- effective techniques/ technologies for combating this negative environmental impact of this sector.
BIOT has coordinated two projects within the FP7 SME instrument programme to respond to the need of olive oil producers by offering an optimised biotechnological recycling solution for olive washing wastewater using photobioreactors (PBR). The technical viability of the process in industrial end use conditions has been sufficiently demonstrated in these two past projects: algatec\ treats olive washing water efficiently so that treated water complies with wastewater legislation, and treated water can be reused. Now, there are still two techno-economic challenges in order to put our product in the market that will be tacked during an eventual SME instrument Phase 2. Reduce the impact of the seasonal nature of this industry on the treatment process that (larger PBR system and increased operation costs of the treatment.
Therefore, BIOT objective in this proposal is to determine the techno-economic feasibility of transforming algatec\ in a closed-loop system by including two auxiliary services: (1) Open pond pre-treatment and (2) algae biomass valorisation as biofertiliser for the own olive fields. The former will be done by the optimisation of the population of microorganism currently treating wastewater to be later used (after harvesting) as a slow-release biofertiliser.";71429;50000;H2020-SMEINST-1-2014;SME-1;Biotmicrogen S.L.;ES;;; 196546;673983;SPM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Strawberry Processing Machine;1/06/2015;30/11/2015;;"The fruit and vegetable processing market is growing exponentially driven by the increasing demand of frozen products, juices and ready-to-use products. In this context, industries that process very sensitive fruits are facing great difficulties/challenges to increase their competitiveness. Indeed, this segment is unable to fully benefit from the industrial technologies like automation and artificial vision - already used in other segments - to increase the productivity, the quality and the safety of the final product as well as working conditions.
Attempts have been made for this purpose but solutions proposed until now are not enough automated resulting in low processing cadence and thus, high payback period of the machine.
In order to address these concerns, Orizon Vision and AcessoMatic combined their skills, respectively in artificial vision and automation, to develop an innovative machine able to automatically manipulate and cut the green zone or calyx of at least 10-12 strawberries of all caliber per second. In this case, our artificial vision software will identify with precision by colour the cutting zone on the strawberry duplicating the processing cadence of existing solutions. By reaching first the strawberry market that increased 16% a year in the last 10 years, our goal is to expand this technology to the processing of other very delicate fruits or vegetables like persimmons, figs, peaches, etc.
This innovation project constitutes a great opportunity for the participating companies, Orizon Vision and AcessoMatic, to develop a high value and disruptive solution which can reinforce their position in the market and increase their visibility around the world. For that purpose, we need to refined and matured our initial business plan. Hence, the feasibility study would significantly leverage our business proposition to reach the market and enhance the possibility of successfully applying to Phase 2 in the SME Instrument in order to demonstrate our machine.";71429;50000;H2020-SMEINST-1-2014;SME-1;ORIZONVISION LDA;PT;ACESSOMATIC COMERCIO COMPONENTES PNEUMATICOS HIDRAULICOS E ELECTRICOS LDA;PT; 196539;673729;PreNANOCOAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Metal powder coating system with nano-technology pre-treatment.;1/05/2015;31/08/2015;;"preNANOCOAT presents a new innovative metal powder coating system for metal tubes manufacturing industry. Metal tubes coating is a major issue, since tubes performance depends on its perfect coating. ANDERLINI MECCANICA SRL presents a new system for the coating of its tubes, with an innovative approach that includes a newly developed nano-technology pre-treatment, IR/UV curing and a specillay designed gripping device that, altogether with a compeltely automated process, ensures both the quality of the coatings as the best possible environmental techniques.
Standard coating systems use dangerous substances such as phosphates and chromates, generating also important amounts of hazardous sludge that needs waste treatment process. Estndar curing ovens are big and demand enormous amounts of energy, as standard curing time of the tubes is never inferior to 20 minutes.
Our new innovative system avoids the use of phosphates and chromates and generates no sludge at all. By the use of IR/UV curing mechanisms, necessary curing time is reduced to just 3 minutes, with the consequent save in enery resources.
Finally, with our specially designed gripping deviced, soon to be patented, and our completeley automated conveyor, we will ensure proper health and safety conditions for our workers, which is not always taking into account in most powder coating facilities.";71429;50000;H2020-SMEINST-1-2014;SME-1;ANDERLINI MECCANICA SRL;IT;;; 196548;674067;ReDurComp;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Novel business on DURable and COMPostable products based on REcycled plastic;1/05/2015;31/10/2015;;"More than 25 million tonnes of plastic waste are produced every year in the EU28 (50 kg per EU citizen). Although the rates of plastic waste recovery have increased (26% mechanical recycling; 35.6% energy recovery), 38.4% of this waste is still landfilled (9.6 million tonnes). This goes against the EU Waste Framework Directive 2008/98/EC as it has a high environmental impact (0.105kg CO2/kg plastic waste landfilled; production of one million tonnes of CO2) and wastage of resources (590/tonne of recycled plastic ; losses of 5,664 M).

INTERVAL, S.A. is a family-owned business created in 1982 specialised the recycling and transformation of plastics. We employ 22 people and have an annual turnover of 3,240,066. We produce more than 7,000 tonnes of plastic products per year using the most advanced technology in our production processes.Through ReDurComp, we aim to launch innovative, low-cost products onto the EU market based on premium recycled PE. We will start by introducing two products for which a clear market need has been identified (i.e. plastic sacks for household waste collection and plastic covers for pallets). As a whole, sales of about 48.3 million are forecast within a five-year period, generating profits of over 4.8 million.

During phase 1, a feasibility study including a business plan will be developed in line with the overall internationalisaton and growth plan of our company. This study will include: (1) a market assessment to confirm INTERVALs products acceptance in the two segments considered; (2) a technical assessment to validate our recycled PE material according to relevant EU standards and procedures, as well as final testing; (3) a stakeholder assessment to identify the key players and activities for the second and third phases of the project; (4) a complete Business Plan including a cost analysis of raw materials and production activities, marketing and sales strategies, target market, investment requirements, and sales partners.";71429;50000;H2020-SMEINST-1-2014;SME-1;INDUSTRIAS TERMOPLASTICAS VALENCIANAS, S.A.;ES;;; 196475;672801;Vaprosep;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Validation of Progranulin as Biomarker in Diagnostics and Prognosis of Sepsis;1/05/2015;30/09/2015;;"Sepsis is a complex, systemic and inflammatory host reaction on an infection and with worldwide 1.5 million cases per year a health challenge. There is a strong need for a reliable biomarker like progranulin. Preliminary data prove that progranulin allows a highly sensitive and specific detection of sepsis, a monitoring of infection without time delay, prognosis regarding disease course and a differentiation between the infectious agent inducing sepsis.

Economic advantages of progranulin as biomarker are the reduction of the length of stay in the ICU (500-1000 / day) and avoidance of unnecessary antibiotic therapy (10-500 / day).
Thus, the hospital can improve patient care and reduce therapeutic costs by a progranulin measurement for 5-10. A mean incidence rate of 0.094% results in a 12 million euro market in the US and EU. Based on intellectual property this market is available only for Mediagnost. Successfully validated, progranulin measurement will be introduced in third level hospitals in the EU. The subsequent strategic product development includes point of care and multiplex test systems.

Mediagnost already has a technically validated test system for this biomarker available, therefore the overall objectives of this study are the clinical validation of progranulin measurement in sepsis and its implementation in clinical routine. Specifically, in phase I the economic potential of this biomarker is evaluated.

These objectives are addressed during phase I in a feasibility study including market and cost analysis. Key opinion leaders in the EU are interviewed by a structured questionnaire to evaluate scientific solidity and market potential. In direct contact to EU Notified Bodies the best regulatory strategy is evaluated. Further, literature research will complete the picture of the market and reimbursement requirements. Excellent infrastructure and highly qualified scientific and administrative employees guarantee the successful completion of this work.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH;DE;;; 196562;674446;SOLID;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Satellite-based Observation of Land Infrastructure Deformations;1/05/2015;31/10/2015;;"The overall objective of our project is therefore to design, build and run an innovative end-to-end service for continuous and automatic GNSS deformation monitoring based on a new generation of low-cost GNSS receivers (Global Navigation Satellite System, including GPS and Galileo), prototypes of which are currently being developed by GReD and selected partners.
The objective of the feasibility study is the development of a business plan to confirm the potential market and benefits, identify application fields and to estimate the investments needed for designing, building and running an operative end-to-end monitoring service. The business plan will also consider intellectual property management, sales channels to reach the market and economic metrics for the service pricing and delivering.
The overall activities of the project are foreseen to be completed within 6 months.";71429;50000;H2020-SMEINST-1-2014;SME-1;GEOMATICS RESEARCH & DEVELOPMENT SRL;IT;;; 196476;672851;FREE-D;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;CNC dynamic mold for producing freely curved glass panels;1/05/2015;31/10/2015;;"Although the development of computing tools has been quite successful, the development of cost-effective, high speed and sustainable production processes for complex curved glass panels lags behind. In this integral innovation project, Free-D Geometries B.V. (Free-D) will bridge this gap by developing a highly advanced CNC dynamic mold prototype for production of curved glass panels: the Dynamic Glass Mold. This active pinbed with embedded transforming technology enables manufacturers to add freely doublecurved panels (3DC panels) to their product range, while highly optimizing the existing single curved panel production and logistics.

Free-D will partner with a glass manufacturer for developing the mold technology. Selling or licensing the technology to firms working in other regions will subsequently be considered. Secondly, Free-D will intensify its collaboration with SMEs in specialized markets. The modular, cost-effective, easy-to-maintain, high resolution production system with multi-actuator units can also be applied for many other materials.
The glass manufacturing sector will be engaged with highest priority. The production technology of Free-D will enable computer-controlled mass production of uniquely formed 3DC glass panels. Curved glass panels will find many uses: from yachts to entire building envelopes. This technique will be a game-changer, pushing innovation in a wide range of sectors. Spill-over effects to other sectors of industry will be achieved, for example where transforming requires very high-resolution bending under high-temperature production environments.

The key aim of this feasibility study is to establish:
1) a partnership with a glass manufacturer for prototype demonstration.
2) a business plan.
3) feasibility of the production of the advanced CNC dynamic glass mold.";71429;50000;H2020-SMEINST-1-2014;SME-1;FREE D GEOMETRIES BV;NL;;; 196435;672213;LOUISA-3D;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of Laser Optoacoustic Ultrasonic 3D Imaging System Assembly for breast cancer detection and characterization through endogenous biomarkers.;1/05/2015;31/10/2015;;"Breast cancer (BC) is the most common cancer and the first cause of cancer-related deaths in European women. Laser Optoacoustic Ultrasonic 3D Imaging System Assembly (LOUISA-3D) combines optoacoustic functional information from endogenous biomarkers (hemoglobin content and blood oxygen saturation) with high-resolution anatomical images of ultrasound tomography, without the need for ionizing radiation or exogenous contrast media. The objective of LOUISA-3D is to overcome the main limitations of current imaging methods, by validating and introducing to the EU market a novel multi-modality diagnostic device for BC, based on coregistered full view 3D optoacoustic and ultrasonic technology. LOUISA-3D will be a highly effective, safe and affordable imaging method for BC detection, characterization, and evaluation of the effect of neoadjuvant therapy (NAT).
Two clinical trials will validate LOUISA-3D. Trial 1 will measure detection rate, recall rate, sensitivity, and positive predictive value of LOUISA-3D as a screening test in a selected female population at increased risk for BC, as compared to standard digital mammography. Trial 2 will assess the LOUISA-3D endogenous biomarkers capability of measuring the NAT effect in the treatment of locally advanced BCs, as compared to contrast-enhanced magnetic resonance imaging. During this feasibility study, an international scientific committee will deliver both trial protocols, and a management board will release a work and financial plan for the trials and a business plan for the production and commercialization of LOUISA-3D, complete market analysis, cost analysis and financial plan.
The applying company, Bios, commercializes medical laser systems worldwide. Once validated and CE medical marked, LOUISA-3D will be manufactured and commercialized in EU, representing an important opportunity for Bios to enter the medical imaging market and enable its significant growth.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOS S.R.L.;IT;;; 196507;673476;HW2000;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Hydrowashr 2000;1/05/2015;31/10/2015;;"'Hydrowashr has developed an all-in-one washing device which will save up to 99% of water each time someone uses it for washing their hands. Next to that it is a disruptive innovation in the sanitary market, in the light of environmental, economical, hygienically and aesthetic values.
This proposal describes Hydrowashrs innovation and why a feasibility study will be necessary to further develop, validate and commercialize the innovation: the HW2000. Hydrowashr has developed HW2000 (Hydrowashr 2000): a product, based on an innovative spraying system, which allows individuals to wash their hands in a more sustainable and hygienic way. How it works: the user puts his hands into the HW2000. The, completely touch free, washing process works with microscopic droplets of water that are fired on the skin trough a rapid flow of air. Then the hands are dried in the same air flow. After 20 seconds, the hands are clean, dry, warm and soft. Because of this new spraying technology, up to 99% water will be saved each time. At the same time the system cleans hands better than existing solutions, providing better hygiene.
Hydrowashr B.V. has been founded in 2012 and is specialized in water technology. Hydrowashr is located in Leeuwarden, the Capital of water technology. In Leeuwarden the Water Campus allows companies to develop and test innovative water technologies.
Fresh water is globally becoming a scarce resource. In a research of 2007, initiated by the European Commission, water scarcity and drought is identified as a growing European problem. According to the report, water savings will help addressing these problems. Additionally water savings will provide financial, economic, environmental and other additional benefits. The importance of innovative water solutions is also stressed by the fact that water is one of the main focus areas of the Horizon2020 work program 'Climate action, environment, resource efficiency and raw materials Challenge'.'";71429;50000;H2020-SMEINST-1-2014;SME-1;HYDROWASHR B.V.;NL;;; 196437;672246;MicroLAB;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;MicroLAB lab-on-a-cartridge, a disruptive concept. Towards an innovative solution for food safety;1/05/2015;31/08/2015;;"The main aim of this proposal is to generate an updated revision of GTZs initial Business Plan (BP I), to overcome the main challenges detected for the successful MicroLAB market launch. The following aspects will be pursued: 1) specific marketing tools and sales strategy (Europe, North and South America, Asia) devoted to feedstock producers and micro & small food companies (50 employees), to speed up, the market share achievement (2,6%); 2) product innovation policy to assure the company growth in the food safety business; 3) technical feasibility study for a cost-effective production process (<5 /device) and its lay-out definition; 4) revision of the organization growth plans to assure its sustainability; 5) and an updated review of the economical and financial plans. The food sector is the second largest manufacturing industry micro, small and medium sized companies suppose the 99. The business size profile has a relevant impact on the deployment of the safety assurance measures and the feedstock sustainable production (minimization of waste and GHGE). Due to the micro and most of the small companies size (< 20 employees), the accomplishment of the mandatory plans for quality and food safety assurance, makes of it a big hurdle difficult to overcome. Alternative rapid kits have been developed to facilitate food pathogen assessment, but none of them, covers the whole microbial detection routine in an easy and affordable way. So, micro and small food companies ought to outsource this service (18-20 /test, 8,500 /year), with the added drawback of relying a very sensitive issue in third parties. The small dairy, meat and poultry farms, cant cover these controls, being assumed by the secondary transformers, with the additional costs of logistics, cross-contamination and factorys stops, if feedstock refuse. The solution has been carefully considered, and its a challenge that GTZ is eager to assume, by the manufacture and the market launch of MicroLAB.";71429;50000;H2020-SMEINST-1-2014;SME-1;GTZ MICROLAB DETECT SL;ES;;; 196504;673428;PAIR;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Plasma active pollution control system;1/05/2015;31/10/2015;;Innovative active air pollution control system based on plasma technology.;71429;50000;H2020-SMEINST-1-2014;SME-1;GRINP SRL;IT;;; 196421;671873;ERMOS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Enhanced Resolution MRI Ocular Scanner (ERMOS);1/05/2015;31/10/2015;;"Enhanced Resolution MRI Ocular Scanner
The objective is to show the feasibility of an innovative low cost, high resolution, dedicated MRI scanner to be used for ocular MRI. The main elements of innovation are: a very compact 0.2T magnet, a receiver (HTSRx: High Temperature Superconducting Receiver) composed of an array of 3 orthogonal high Tc superconducting coils that will allow reaching the resolution of high field superconductive whole body scanners. The scanner is intended to be used directly in the ophthalmic clinic without the need of sending the patient to a diagnostic imaging department. This changes the clinical path of the patient and is capable of guarantee a better quality. An ophthalmologist with experience of MRI techniques has, in fact, a much better understanding of what the specific images of the eye and of its surrounding mean in the context of the patient clinical picture. The scanner can also be used in the traditional diagnostic imaging departments reducing the queues on the whole body apparatuses.
ITA srl has done all the development of the apparatus using room temperature receivers and under the Phase 1 project the HTSRx will be tested to show the technological viability of the device. In addition the Phase 1 activity will take care of IP protection and of selecting and contacting clinical/research centers that can associated in a Phase 2 project that has the purpose of demonstrating the diagnostic capabilities of the scanner.
Potential users are ophthalmology and diagnostic imaging centres. Given that the percentage of elderly in the population is very high and that eyes diseases characterize the advanced age the number of these centers is high. At moment most imaging diagnostic centers do not have specific eye coils and, when required, the analysis is performed using head coils that give a relatively poor resolution. Never the less a fixed percentage of patients that goes for eye patholare required to perform an MRI analysis.";71429;50000;H2020-SMEINST-1-2014;SME-1;IMAGING TECHNOLOGY ABRUZZO S.R.L.;IT;;; 196439;672296;URO-BEST;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;UROthelial carcinoma Biomarker based diagnostic tEST;1/05/2015;30/09/2015;;"Bladder cancer is among the five most common malignancies worldwide: more than 380.000 new cases are diagnosed yearly. If detected early, 5-year survival is high (94%),but >70% of diagnosed patients will relapse within this period.
The current gold standard diagnostic tool is combined cytology and cystoscopy which is costly and highly invasive requiring transurethral access and presenting the risk of important complications. Due to high relapse rates, surveillance requires frequent cystoscopies, averaging 13 controls per patient after initial diagnosis. Hence, bladder cancer is one of the costliest cancers to treat and monitor. Only in the USA, Europe and Japan, more than 4.5 million cystoscopies are conducted yearly, 40% for 1st diagnosis and 60% for surveillance, at a cost near to $2 billion to healthcare providers.
Urologists believe that an opportunity exists to reduce the number of SURVEILLANCE cystoscopies with a reliable, cost-effective, robust, easy-to-perfom and non-invasive assay.
URO-BEST addresses this unmet need. Based on signatures of 2, 5,10 and 12 differentially-expressed genes, this test has been clinically validated in a multicenter international study on 525 urine samples demonstrating 81% sensitivity and 91% specificity in discriminating cases vs. healhty patients for first diagnosis, figures comparable to that of the gold standard and superior to other existing molecular diagnostic products (Urovysion, NMP22, BTA Stat). We estimate the current market for bladder cancer biomarker based tests at greater than > $200million.
Fina Biotech has filed European and PCT patent applications protecting the invention in 2013.
Fina Biotech aims to clinically validate the diagnostic performance of the genetic signatures in patients under SURVEILLANCE for its launch to the market: advance ongoing discussions with potential partners for global licensing, increase urologists awareness and secure freedom to operate.";71429;50000;H2020-SMEINST-1-2014;SME-1;FINA BIOTECH S.L.;ES;;; 196533;673834;EcoSpacePropulsion;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Piloting and upscaling the unique on site and mobile production plants for highly concentrated Hydrogen peroxide (HTP) production for space industry applications;1/03/2015;31/05/2015;;"The overall objective of the project is to commercialize the unique technology for production of 98% concentrated HTP. This will be developed and exploited twofold: (2) Construction and installation of the technology line located at our premises and distribution of 98% HTP to the customers; (2) Construction and application of a container based mobile plant that will be able to produce HTP at the clients premises. This solution will be tailored for the customers with regular large demand for the HTP and to whom the delivery of the ready product will be problematic due to formal and legal constraints concerning transportation limitations.
This dual approach derives from the limitations in HTP transport which under international laws and conventions is disalowed by other means than through road and water paths.
HTP might be used for space rocket engines both as a single-component propellant, or as an oxidant. It is the only substance offering both applications. It is furthermore neutral for the environment, as the only products of its chemical decomposition are Water and Oxygen. At present, however hydrazine has been widely applied as a primary propellant in various rocket fuels. Hydrazine is highly toxic and dangerously unstable unless handled in solution. Nowadays in the era of increasing concerns for the environment and safety of humans, we witness extensive research for non-toxic, safe, affordable, easy to store and of high energy density, single-engine propulsions and oxidizers for the space industry. In this situation, there has been as increased interest in application of highly concentrated HTP. Due to regulations banning of HTP transport by air there are considerable supply shortages of highly concentrated HTP both for research and industrial applications. At Jakusz we want to overcome this limitation and bring to the market high quality 98% HTP produced and distributed according to the tailored needs of the customers.";71429;50000;H2020-SMEINST-1-2014;SME-1;JAKUSZ SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA;PL;;; 196524;673863;BDoSM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Big Data of Small Molecules;1/05/2015;31/10/2015;;"As Google mapped and photographed the streets and terrain of our planet, the main objective of the project is to map and spectrally fingerprint the small organic molecules of various organisms and introduce to the market a fundamentally new cloud driven compound identification platform.

Our pioneering solution will allow continuous identity assignment of unknown molecules in biologically relevant samples by developing a technologically mature architecture and infrastructure for storage, processing, search, exchange, analysis, data mining and visualization of millions of spectral, structural, chromatographic and biochemical data of small molecules.
Our project will become the world most comprehensive database platform of spectral fingerprints of endogenous metabolites, natural products and environmental contaminants that will allow identification of substances present in biological samples that could not be identified using conventional technology that is a crucial bottleneck in many biotechnological and pharmaceutical applications.

Since the biomedical, pharmaceutical and biotechnology industry in general are constantly detecting numerous unknown compounds and searching for new biomarkers and disease specific targets, our technology platform is direct response to their needs with the prospect of new business opportunities and future growth.

The feasibility study will be important for acquiring additional financing of the project, to review technological solution (most effective and sustainable, without infringing patents, copyrights, and trademarks of third parties), to precise marketing strategy for corporate, small group & individual users, to identify, clarify and protect own inventions, new approaches and new technical solutions. Finally, the Phase 1 outputs will give perfect review on project management plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;HIGHCHEM SRO;SK;;; 196508;673477;PCMPS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Precision Cancer Medicine Pipeline and Services;1/05/2015;31/10/2015;;"'Cancer cost the EU 126 billion in 2009, while in 2010 the US spent a staggering $124.6 billion on treating cancer. This cost is set to rise as the effects of an aging population and increasing life expectancy take their toll. These market drivers will put an intolerable strain on health services across the western world, forcing governments to streamline their health services.
Current cancer treatment is based on the 'average cancer patient', meaning some cancer patients may not respond to the treatment while others do. Thus it is clearly is a need for solutions that offer precision cancer medicine.

PubGene AS aims to pursue a major market opportunity by developing a complete pipeline for precision cancer medicine (PCMPS), that include the necessary steps from Next Generation Sequencing to clinical treatment support for cancer patients. The biggest beneficiary of PCMPS will be the patient, who will receive a personalized treatment rather than a hit and miss approach to therapy. This will improve patient outcomes and ensure patients no longer have to suffer harsh side effects from non-efficacious treatments. The second beneficiaries will be the health providers and payers, as doctors will no longer waste time and money prescribing ineffective treatments. Nevertheless, despite the benefits of personalized cancer medicine, it is crucial to validate and demonstrate the benefits of this type of cancer medicine before large-scale commercialization.

PMCPS is an opportunity for PubGene to expand our suite of applications and enter into complete new market for PubGene - targeting the treatment market. The project will give us a head start in providing tools in the field of personalized cancer medicine, ensuring us strong positions in the future European and worldwide markets. Accomplishment of the project will represent a significant business opportunity with an expected annual turnover of 17 million with a 25-30% annual increase, 3 years after commercialization.'";71429;50000;H2020-SMEINST-1-2014;SME-1;PUBGENE AS;NO;;; 196532;673710;BEEP-WATER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Biosensor for Effective Environmental Protection through the on-site, automated monitoring of a large set of chemical contaminants in Water.;1/05/2015;31/08/2015;;"The Drinking Water Treatment Industry is subject to a stringent legislation regarding contaminants in water. Quality of water intended for human consumption and its monitoring are regulated under the drinking water directive 98/83/CE. Pesticides and heavy metals must be monitored and tested regularly with maximum allowable concentration of 0.1 ?g/l for individual pesticides and 0.5 ?g/l for the total amount of pesticides. The directive 2013/39/EU concerning emerging contaminants to be controlled in the field of water policy establishes what contaminants are identified for priority action at Union Level.

Most important for the Drinking Water Treatment Industry is the cost associated to contaminants detection: approximately 160millions are invested in pesticide water analysis in Europe. Currently, a pesticide analysis costs an average of 300 per sample since it requires specific staff and high technology equipments.

We have developed a prototype of BEEP-WATER biosensor technology able to detect and quantify on site a wide range of chemical contaminants including pesticides, heavy metals and emerging contaminants in water saving the cost associated to current laboratory analysis.

The objective of our current project is the industry adaptation and implementation in the Drinking Water Treatment Industry of BEEP WATER early warning system as a real quick and inexpensive alternative to current contaminant analysis systems in water.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOSENSOR S.R.L.;IT;;; 196545;673972;FireFree;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;New generation of halogen-free high performing flame retardants for plastics, free from persistant, toxic and bio-accumulating substances.;1/05/2015;31/10/2015;;"The objective of FireFree is to launch the 3rd generation of the patented, halogen-free Paxymer technology on the market. The technology is proprietary and patented, it employs a multi-mechanistic approach for achieving fire safety and meeting fire standards without the use of persistent, carcinogenic or endocrine disrupting chemicals. Implementation of FireFree will increase the usability of cheaper and more sustainable plastic materials with significant societal savings as a consequence.
The main drivers for a successful implementation are two main market trends: utilization of cheaper materials and reduction of hazardous chemicals due to regulation and CSR policy. There is an increased use of the type of plastics that FireFree targets driven by material development, environmental benefits, price and weight reduction. Secondly the growth of the halogen-free flame retardant market driven by restrictions on halogenated flame retardants and new harmonized fire standards that aim to achieve improved safety and environmental performance of products.
The objectives of the feasibility study is to further understand and prioritize the demands of the plastic manufacturers and OEMs and develop a detailed business plan. Moreover, it will outline the necessary steps to achieve successful market introduction of the new generation of products including key partners and key product characteristics. Finalizing a preliminary technical evaluation as well as specifying partners in the supply chain will be concluded during phase 1. The second phase of the project aims to fully develop, demonstrate and bring the new generation of products from TRL 6 through 9 and launch projects on the market with lead users for final proof of concept focusing on applications within electrical and electronic equipment (EEE), building and transportation industries.";71429;50000;H2020-SMEINST-1-2014;SME-1;PP-POLYMER AB;SE;PAXYMER AB;SE; 196461;672637;CLEV;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Most cost and time efficient EU-wide cross-border automated parcel delivery solution;1/05/2015;31/08/2015;;"Cleveron has developed the most modern and efficient automated parcel delivery solution (APDS) in the world lowered delivery price by 50% and granted seamless, easy to use service. The projects vision is to develop and implement EU-wide APDS that will offer high efficiency and exceptional consumer satisfaction in cross-border parcel delivery (in a fast growing 4bn e-commerce market). Cleverons main innovation is to use existing key success factors (optimisation algorithms, collaboration with stakeholders, integration into the value chain, and use of custom designed parcel lockers) and create international information infrastructure for e-retailers, consumers and collaboration of parcel terminal networks, carriers, individual carriers, and logistics service providers along value chains. Innovation project results (APDS technologies/services) serve interests for all stakeholders by decreasing delivery costs by 50%, allowing international next day delivery and improve vehicle load rates.
Phase I (feasibility study) will determine early adopters, specifications and requirements for phase II, and specifics of different EU countries, elaborating development plans for phase II. Phase II will involve the implementation of EU-wide APDS pilot. By the end of Phase II, early adopters will become a part of the business model (partners) or paying customers. Phase II budget is estimated to be 3.6m.
This project will drive drastic improvement in efficiency and load rate of vehicles in the EU logistics sector. As a result, new high value added jobs in transportation sector will be created. After proven performance in the EU, APDS technologies/services could be applied worldwide and/or to more value chains where efficiency can be improved. Fostering efficiency improvement in transportation and limiting the pollution is a global challenge.";71429;50000;H2020-SMEINST-1-2014;SME-1;CLEVERON OU;EE;;; 196460;672626;TEMPERATE CO2;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;TEMPERATE WELDING;1/05/2015;31/10/2015;;"Develop a complete, highly efficient MIG-MAG welding equipment (600 A, 30 kW) with unity duty cycle factor, entirely designed to fulfill the needs in the metalmechanical sector. Additionally it offers considerable advantages in automated applications. A ground-breaking power supply technology developed by DEGIMA in collaboration with the University of Cantabria will be at the foundation of this new equipment. DEGIMA owns the European Patent of the power supply technology (EP 2 286 949 A1 /2011): Electronic system for optimizing energy transfer for welding equipment.
Despite the advances in new inverter systems, current welding equipments require lots of power, overheat the workpieces and generate sparking that produce defects in the weld line.
This new technology significantly reduces power use and CO2 emissions, keeps heat input to the workpieces to a minimum, provides full control of the welding parameters and avoids sparking and projections producing a weld line that is completely steady. This results in a faster welding process that yields a longer weld per unit of time and per volt-ampere used. Each one of this new welding equipment could save up to 20.000 kWh per year, which multiplied by the expected accumulated number of units sold by the 4th year yields savings reaching the 145 million kWh.
With the help of this technology brought forth by DEGIMA and GALA GAR (partner and welding equipment manufacturing company), Europe can lead the third generation of welding equipment, much highly energy efficient than the previous, which will grant competitive advantages to all sectors involved into intensive welding activities. It is only a matter of time for the majority of welding equipment to be energy efficient. Reducing emissions of greenhouse gases would be awesome.
Our first target clients will be the automatic MIG welding process from metalmechanical companies which we plan to approach with commercial actions and demonstrations of the qualities of this equipment.";71429;50000;H2020-SMEINST-1-2014;SME-1;DESARROLLO Y GESTION INDUSTRIAL Y DEL MEDIO AMBIENTE SA;ES;GALA GAR S.L.;ES; 196393;666473;NEC14;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;New Electric Vehicle Chassis-Cab 10-14 for urban logistic;1/04/2015;31/03/2017;;"Muses is an electric chassis-cab manufacturer for deliveries (parcels minus 30 kg) in cities. Our vehicles (Mooville) received the N1 (-3T5) homologation for a volume up to 9 cu.m. Mooville is the only electric N1 chassis-cab with this capacity in Europe.
The objective of NEC14 program is to launch, on European market, an electric designed vehicle 10-14 cu.m, in response to the high demand of European delivery actors.

Cities need to have sustainable deliveries, emitting neither gas nor noise pollution, as wished by U.E. citizens. Major delivery actors look for reliable, zero CO2, zero fine particles, zero db vehicle, business relevant and industrial solution, with the right Total Cost of Ownership. For example 3 of our customers, Chronopost International, DHL and EXAPAQ-DPD have their current fleet of thermal vehicles with volume between 10 and 12 cu.m. and a TCO around 1100 per month. They are definitely interested by our NEC14 project, and have insisted to be actor of it.

Today there is 3 categories of vehicles: quadricyle, N1 (-3t5), trucks. It exist many small electric quadricycles. Gaz and electric trucks (up to 12 tons and plus) also exist. But in the -3T5 category the only vehicles are derived from person vehicles (like Renault Kangoo, ) and offer less than 4 cu.m. Above that nothing between 5 cu.m and 16 cu.m. Our customers, our leasers confirm this current, and for still 3 years at least, situation: Mooville 4-9 is the only one vehicle and not any 10-14 cu.m clean vehicle on European market.
Some of our Clients such as Exapaq (DPD), DHL and Chronopost, world leaders in the delivery business, have already decided to support us (See enclosed interest letter of these three companies). They will participate in the different stages of NEC14 program.

NEC14 is a two years project which includes [1] three prototype vehicles to be tested by partner clients, [2] a marketing and commercial action plan and [3] the preparation of the sales force implementation.";2492435;1744704,5;H2020-SMEINST-2-2014;SME-2;MUSES SAS;FR;;; 196547;673998;INNOEM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Innovative energy management technology for smart energy decisions;1/05/2015;31/10/2015;;Watty can pin-point the smartest way to save energy in any home with just a single piece of low-cost hardware. Our innovative technology analyses the total energy use in a household and breaks it down into its components, i.e. the energy use per appliance. The technology deciphers a distinctive behaviour and usage pattern for every appliance and is thus able to diagnose the entire energy usage of a household in detail. The implementation of this technology will for the first time permit households to make concrete, smart energy saving decisions based on detailed data about the real-time usage of their appliances. As this can help households save 10-30% of their energy use, it will both help the users to reduce costs, while at the same time make a large contribution to the EU objective of a 20% energy saving by 2020. Our product offer is composed by a single piece of low-cost hardware for data gathering and additional software components for the data read-out and analysis. In our envisaged innovation project we envisage to scale up the existing prototype for the hardware, and further develop the software analysis to fully meet the needs of the users. The market for our products closely follows the roll-out of smart meters across Europe. The total addressable market is estimated to 50 million households in 2015 (Nordic countries and Italy), but is expected to grow to 400 million European households within the next five years, thus opening up great opportunities for the commercial exploitation of our technology. The IMMOEN project aims at conducting a market study and defining the business strategy needed to full exploit the commercial potential of our innovative technology on energy markets across Europe. The end result of the project will be a detailed business plan that fully meets the user needs and market conditions in Europe.;71429;50000;H2020-SMEINST-1-2014;SME-1;WATTY AB;SE;;; 196420;671868;I-WSN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Intelligent Wireless Sensor Networks for Asset Integrity Monitoring;1/05/2015;31/10/2015;;"The objective of I-WSN is to develop a low-cost and large-scale solution for automated Condition Monitoring and Predictive Maintenance that will have a disruptive impact on the offshore Operations and Maintenance market. The solution is based on intelligent Wireless Sensor Networks that monitor the long-term trend in the status of the equipment and can predict damages at an early stage. The focus market segments for direct application of I-WSN are offshore Oil & Gas and Wind Energy. We have already received significant interest from potential business partners in this market segment, ranging from global suppliers (Honeywell), to maintenance providers and even Oil & Gas giants (BP).

Unlike existing condition monitoring systems, which are very complex and expensive, I-WSN focuses on a low-cost solution (target price 500/unit) that can be installed on a large number of devices, machinery, equipment and structures. This brings significant benefits to the end-users, such as:
- Up to 75% cost reduction of maintenance operations: extension of maintenance intervals, reduction of workload of maintenance personnel.
- Up to 90% cost reduction of installation of monitoring equipment: wireless sensors compared to traditional wired systems.
- Real-time feedback and continuous monitoring within minutes, as opposed to weeks or months for time-based inspection.

I-WSN will build upon the success story of the FP7 project WiBRATE, showcased in two FUTURIS episodes on EURONEWS in 2014. The WiBRATE wireless sensor platform will be used as the basis, since it has been already validated in industrial settings (at FIAT, Honeywell, LMS-SIEMENS). I-WSN thus starts from TRL6 and higher, and has the potential for Open Disruptive Innovation in an offshore Operations & Maintenance market estimated at 2-3 billion.

Phase 1 of the SME instrument has the objective to check the economic, technical and operational feasibility, and to bring us closer to marketing a successful product.";71429;50000;H2020-SMEINST-1-2014;SME-1;Inertia Technology B.V.;NL;;; 196422;671937;MARVIN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Independent Smart Machine-Vision Based Cargo Counting Module;1/05/2015;31/10/2015;;"Alekon Cargo will develop and commercialize a fully automatic, high accuracy machine vision based scanner for handling and counting of neo-bulk cargo. Today, manual counting and loading of cargo is one of the biggest bottlenecks in European and global logistics chains. Besides time-consuming process, the manual method requires a lot of workforce and is prone to human errors. Each error in logistics business leads to incorrect documentation, delays in customs, fines and unsatisfied customers. Therefore, in order to increase the accuracy and cargo processing time, Alekon will introduce a totally independent, configurable and low-cost solution for cargo operating businesses like logistics hubs, postal services, large manufacturing units, warehouses, rail and road transport hubs, etc.

Alekon together with its scientific partner Tallinn University of Technology has developed a machine vision based scanner system that has multiple benefits compared to current warehouse automation systems. Machine vision based solution has very high accuracy and does not depend on additional labeling (barcode) or sensors (RFID) that need investments and arrangement within the whole logistics chain. Alekon has already established a large sales network in EU and globally as the company has more than 20-years of experience in logistics, crane equipment sales and other warehouse management operations. Alekons innovative solution has confirmed global market potential and great improvement potential over time.

The machine vision based Cargo Counter has very short profitability period as the potential savings from one device may increase up to 200 000 in a year for the end-users. Besides direct economic benefits, the CargoCounter improves workplace safety in logistics sectors reducing the need for difficult manual labour in harsh outdoor conditions.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALEKON CARGO OSAUHING;EE;;; 196492;673188;NUVEA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;The premium green multi-cloud management and optimization tool;1/05/2015;31/10/2015;;"Feasibility study - NUVEA is carried out by the SME New Generation SR, an innovative start-up active in the field of digital technologies and infrastructures. The objective of the overall project is to bring to customers an on-line platform that allows them to take over, manage, benchmark and optimize permanently their distributed IT infrastructure (at the web- and entreprise-grade), independently from the underlying cloud resource provider(s), in a highly flexible and real-time manner.
NUVEA targets cloud computing stakeholders: data center managers, cloud suppliers, big companies with significant in-house IT infrastructures willing to optimize their energy consumption and average server load; public institutions wanting to have fully sovereign or close-to-territory IT infrastructure; and companies having a part of their core competencies cloud-hosted, or significant IT expenditures.
A first version of the algorithm and interface was developed and successfully tested in a laboratory environment. The present feasibility study aims at assessing technical and economical characterics of NUVEAs value proposition through alpha tests on early adopters and in depth market study. This work will enable:
- The release of the first commercial version of NUVEA software (validated on early adopters),
- The definition of technical specifications required for the further development of NUVEA on-line platform (NUVEA platform)
- The elaboration of a detailed business-plan based on operational experience,
- The identification of the preferred stakeholders for european deployment of the solution,
- An updated project executive summary ready for the search of new equity.

Phase 1 will help to finance scientific support and marketing expert required for the feasibility study Later on, Phase 2 would perfectly allow to finance further development plan (from commercial software to web-based NUVEA platform).";71429;50000;H2020-SMEINST-1-2014;SME-1;NEW GENERATION SR;FR;;; 196489;673090;MILANO ROBOT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Minimal Invasive Light Automatic Natural Orifice Robotic Platform;1/05/2015;31/10/2015;;"In the world of surgical medicine there is a major trend towards minimizing the number and size of skin incisions necessary to execute surgeries. This is very appealing from patients perspective, reducing or completely eliminating abdominal wall aggression and reducing post-operative pain. Less invasive surgery is also a major component of shorter hospital stays and quicker return to day-to-day activities by the patient. This benefits the patient, the healthcare system and the social-economic environment in general.
Single Incision Laparoscopic Surgery (SILS) is seen as the new frontier of this ongoing trend. In a SILS procedure the surgeon operates exclusively through a single incision in the patients navel, leaving just one barely-visible scar. However, SILS is very challenging for surgeons, because of the major constraints imposed by both the mode of access and the limited technology currently available.

Valuebiotech (VBT) is an SME, spun off from Niguarda Hospital and AIMS Academy (Milano, Italy) and intends to address this problem through highly advanced robotics technology. This technology is designed to take the robot into the abdomen, and provide (intra-abdominal) the various tools necessary to perform a surgical procedure. The MILANO robot can be inserted via a single incision or natural orifice, and then, once inside the cavity, the robot positions itself to perform surgery.";71429;50000;H2020-SMEINST-1-2014;SME-1;VALUEBIOTECH SRL;IT;;; 196509;673504;EcoVel;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Commercialization of the most sustainable laundry detergent;1/05/2015;31/01/2016;;"With project EcoVel, COIN Consulting UG will realize the first laundry product generating an almost completely closed resource cycle of non-actives (monomolecular fiber, concentrated liquid in combination with solid particles for superior cleaning). The fabric, which even allows for color and fluff catching, is 100% recyclable, does not include any filling additives and has the potential (by further development) to outperform all other laundry products concerning cleaning power. Estimates based on the sustainability report from Henkel 2013 suggest a reduction of the CO2 emissions of nearly 70% by the use of the laundry wipe in comparison to regular powder detergents. The main reason for this reduction is attributable to low weight in transportation and energy efficient production without a counter stream and heating process. This eco-innovation will also have a global effect with respect to climatic issues and green economy.
To market the laundry wipe it is necessary to conduct a feasibility study which includes benchmark cleaning power tests, consumer product tests, IP research and a series of production tests. The results of the feasibility study will allow us to prepare a validated business plan which is necessary for assessing finance and marketing the product through major European retailers.";71429;50000;H2020-SMEINST-1-2014;SME-1;COIN CONSULTING GMBH;DE;;; 196445;672457;TruckSecurity;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Truck Security_ Fuel and cargo theft detection alarm system;1/05/2015;31/10/2015;;"The Project objective is to develop and execute a market replication of IDTEQs alarm system for road transport vehicles. IDTEQ provides a leading technology for secure and reliable alarm detection in remote and noisy environments. The IDTEQ incident detection technology samples and analyses sound. Sensors and proprietary signal processing algorithms detect specific incidents and to discard false incidents.

Fuel- and Cargo theft is a significant problem and a continuous threat to European road transport companies, but it is a criminal activity that is often given low priority.
A prioritised task for the road transport associations is to fight criminal activities in the sector, so the association wanted to find technologies to better protect the trucks. Conventional car alarm systems are not made to handle the specific treats of fuel theft or cargo theft, their market focus is on cabin protection and vehicle tracking. The market development projects have verified strong value propositions for IDTEQs technology. IDTEQ has identified several strategic opportunities which will be developed in order to build a leading product offering for fuel and cargo theft alarm systems on road transport vehicles in Europe.";71429;50000;H2020-SMEINST-1-2014;SME-1;IDTEQ AS;NO;;; 196446;672465;GaSeS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;First low cost handheld infrared camera for fugitive emissions, early detection and location, increasing energy efficiency in industrial plants, infrastructures and utilities;1/06/2015;31/10/2015;;"Nowadays, there is a growing demand of technological solutions to detect and identify leaks in different industries in order to increase its energy efficiency and security.
SENSIA is a cutting-edge technology-based company specialized in the development of infrared imaging devices. Our solutions have been already implemented in high-demanding environments such as SO2 leak finder at Glencore, remote detection in Euro-Fighter wings or high accuracy measurement thermography system for SENER Ingenieria.
This project intends to respond to the needs and requirements from any industries with fugitive emissions problems, but as first step SENSIA will focus on sulphur dioxide (SO2) leaks, and specifically on sulphuric-acid-related industries. This sector relies on gas leak surveys for crucial aspects such as process efficiency, security, environmental care and pollution control.
SENSIA intends to develop and commercialize a low cost uncooled camera based on infrared imaging technology that can easily detect and identify fugitive gas emissions in order to improve the energy and overall efficiency of the chemical, oil & gas, utilities and many other industries. This type of device will be the first of its kind considering that solutions currently available are based on cooled technology, with much higher costs and complexity associated.
The proposed solution will imply clear economic benefits for end users such as:
- Cheaper instrument in comparison with current IR imaging based solutions (at least 1:2 cost reduction).
- Disrupting tool for a better control of SO2 fugitive emissions in short term and many other gases (and markets) in mid-term.
- Compliance with novel and coming laws in terms of fugitive emissions control of SO2 and other pollutants.
The overall objective of this feasibility study is to develop a market study and corresponding business plan that evaluates the main target markets and best strategies to commercialise the proposed technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;SENSIA SOLUTIONS SL;ES;;; 196530;673800;NewMoon;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;NewMoon - Smart Garments in Newborns and Babies Monitoring;1/05/2015;30/11/2015;;"One of the most promising field of application of smart garment is baby monitoring: the most sensible periods of time in the first day of life of a newborn is the first 2-4 hours of life. When the baby is born, for the first 2-4 hours there is no monitoring active; the baby, after a rapid cleaning procedure and first checkup, is given naked to the mother who put him/her on her breast. The skin-to-skin contact facilitate the maternal bonding which consists in different aspects: thermoregulation of the baby, the kangaroo care, cognitive bond, etc. In this period of time, normally there is no ongoing monitoring in order to favor the bonding between mother and child; a discontinuous monitoring is usually implemented through a common visual recognition by the nursery staff. In this hours, in which the baby is in a transient periods from pre to post-natal, a continuous monitoring of bio-signal can be very useful to prevent critical situation. The monitoring system has the purpose to impact on the organization of the work of nursery staff, and increase the quality of the health service delivered through the use of a continuous quantitative monitoring, rather than a qualitative observation repeated over time in a discontinuous manner. This kind of monitoring system tries to be the least invasive as possible for the medical procedure, the baby and the mother. The introduction of a new monitoring procedure in a sensitive environment like the delivery room is a real clinical need we matched with our innovative smart garment embedding textile comfortable electrodes. Recently we investigated the compliance, the reliability and the acceptability of a new monitoring system applied in the first 2-4 hours of life during bonding procedure in a clinical trial with excellent results. This proposal aims at industrially and commercially exploiting the system at national and international level also matching the different regulatory rules.";71429;50000;H2020-SMEINST-1-2014;SME-1;COMFTECH SRL;IT;;; 196534;673735;BI-MARK;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of the CD32b biomarker on the European market;1/05/2015;30/09/2015;;The overall objective of the proposed project is the clinical validation of a novel biomarker for B-cell malignancies. The presently most widely used anti-CD20 antibody treatment rituximab has considerably improved treatment options for patients with B-cell malignancies. However, effectiveness is limited by resistance to rituximab and reduced response on repeated treatments. Data indicates that tumor expression of CD32b is directly involved in the development of resistance to rituximab. CD32b has the potential to be used as predictive biomarker for critical clinical decisions for rituximab and related treatments, and will impact payers and patients. In addition, our company is developing a novel treatment BI-1206 that specifically targets CD32b and significantly improves antitumor effects of rituximab alone. As such, the CD32b biomarker assay has the additional potential to become a companion diagnostic for BI-1206 and other future B-cell malignancy treatments. Our company and the affiliated research team have developed a flow cytometry assay for the detection of the CD32b receptor on tumor cells. The assay has been partially validated in a clinically relevant setting to demonstrate CD32b as a predicative biomarker of therapy response. To achieve market uptake of our technology, we aim to conduct a number of studies together with selected clinical partners in Europe. The objectives of the feasibility study are to find and contact researchers/clinicians for conducting retrospective and/or prospective studies, as well as to refine the business model for the commercialization of the biomarker assay. The intended users of our product are clinicians and therapy developers that focus on B-cell malignancies. By clinically validating a biomarker assay for B-cell malignancies and especially CLL, our company addresses an unmet European and global need for improved treatments for CLL, and B-cell malignancies in general.;71429;50000;H2020-SMEINST-1-2014;SME-1;BIOINVENT INTERNATIONAL AB;SE;;; 196406;666736;AINARA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Automation and INtelligence solutions for Automated Road trAnsport systems;1/05/2015;31/10/2017;;"With an expertise of the highest European level in robotics, \10 years of experience in the field of autonomous vehicles and several proofs of concept in operational environment (TRL6/7), RDS (spin off of ROBOSOFT) is the only European company to master all of the software components allowing Autonomous Road Transport Systems to reach the levels of robustness and reliability required for passenger transport.
Without waiting for the legal framework, which is being implemented thanks to the efforts of the CityMobil2 project, the market study conducted as part of the TAXISAT project revealed that the 1st wave of user demand would emerge in Europe in 2015 for autonomous transport services in pedestrian city centres and private sites such as industrial or theme parks. These markets will grow even faster that the vehicle manufacturers, Transport Organising Authorities or Operators will be able to adapt their services to future mobility challenges. For this, they will need key skills in robotics, intelligence and fleet management. RDS has the means to satisfy them by providing off-the-shelf ARTS AUTOMATION and INTELLIGENCE solutions.
Current solutions are highly customized in an engineering mode and are not compatible with a wider uptake of its technology. To take a solid position on the emerging global autonomous vehicles market and acquire an industrial dimension, RDS is convinced that best strategy is to deliver Commercial Off-the-Shelf software packages, which will offer recurring revenues and promising growth and profitability prospects thanks to software licences sales.
The objective for RDS is now to industrialise its software offer, to be fully compliant with the new EU Directive under development and to test the relevance of the associated business model with the ultimate ambition to become a leader in the provision of software solutions for vehicle automation and fleet management, for passengers and goods transportation.";2312320;1618623;H2020-SMEINST-2-2014;SME-2;ROBOSOFT DRIVERLESS SOLUTIONS;FR;;; 196493;673306;BRAINSPECT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Ultra high resolution Single Photon Computed Emission Tomography for the molecular imaging of brain disease;1/05/2015;31/10/2015;;"MILabs radically new proprietary approaches for ultra-high resolution and ultra-sensitive brain SPECT (Single Photon Emission Computed Tomography) enable the measuring of disturbed regional cerebral blood flow (rCBF) perfusion, and characterising plaques and neurotransmitter imbalance - all important hallmarks of brain disorders - at unprecedented spatial resolutions. This new approach has the potential to disrupt the complete field of molecular imaging (MI), a multibillion market worldwide. Current techniques can only measure the mentioned effects in the brain either at late stages of disease progression (at which point the patients have already been diagnosed) or at insufficient resolution to isolate processes in small parts of the brain. Current SPECT results in low resolution images, are highly sensitive to patient movement and are time consuming and costly. MILabs has developed a clinical SPECT prototype, G-SPECT, which has proven its potential to reposition SPECT as the major clinical MI modality. G-SPECT uses a high bandwidth photon detection ring with multiple pinholes, and advanced reconstruction software that compensates for patient movement artefacts. This enables 35-fold higher resolution images, more accurate imaging and lower radiation dose due to shorter scan times (Figure 1). The application of MILabs SPECT technology in small animals has sparked enthusiasm amongst clinicians and brain researchers worldwide.
In this Stage 1 SME Instrument, MILabs will investigate the commercial feasibility of this exciting technology by (i) identifying and assessing those indications to which the clinical utility yield the best initial market value, (ii) developing a sound clinical validation strategy and (iii) defining the route-to-market.";71429;50000;H2020-SMEINST-1-2014;SME-1;MILABS BV;NL;;; 196516;673566;TES;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Total Energy System: innovative in-farm cogeneration plant for manure valorisation viable even for small farms;1/05/2015;31/10/2015;;"Manure treatment deriving from poultry farms is a continuously increasing problem. Poultry farms are characterized by a lack of proportion between bred animals and farmed area. This imbalance is intensified in farms where there is no agricultural land as in such cases large amounts of manure are generated respect to farmland intended to receive it resulting in intolerable soil and aquifer pollution levels.
Manure collection is costly for farmers and it does not solve the problem definitively. On the other side, farms are energy-intensive and main expenses relate to the consumption of electricity and heat. Using poultry manure to reduce or eliminate such cost, could represent an interesting solution that would become vital in order to maintain farms competitive.
Today existing manure valorisation systems based on biomass combustion are not a viable solution for farms with low number of animals - for economical reasons.
La Coro through the last years developed an innovative solution for this problem. The main objective of the project is the realisation of a pilot plant and market introduction of a highly efficient and flexible biomass cogeneration system that is able to transform poultry manure (but also other manure and biomass types) in thermal and electric energy (total energy system), with the particularity of being usable also in small farms.
The innovative solution will recover and valorise manure through gasification and electricity production, avoid disposal and soil contamination problems, substitute today used fossil fuels thus achieving important benefits for farmers not only in terms of economic savings but also in environmental terms of CO2 reduction. The economic saving on the long run will increase their competitiveness.
In short: waste reuse plus cost reduction equals more efficiency and higher competitiveness.
Market introduction will start from poultry farms, then it will be extended gradually to other livestock farms.";71429;50000;H2020-SMEINST-1-2014;SME-1;LA CORO IMPIANTI SRL;IT;;; 196518;673605;BDuSSCR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;BIG DATA using SECOND SCREEN AND CONTENT RECOGNITION (BDuSSCR);1/05/2015;31/10/2015;;"TV Viewers demand a personalized and richer experience while watching TV. Broadcast TV and producers try to develop interactive products to build a stronger engagement with their audiences. Advertisers are tired of ad strategies that are not measurable nor results?oriented. Most of the broadcasting agents (TV/radio broadcasters, content producers, advertisers and their agencies) have poor information about the current behavior of their audiences. To improve the quality of such information they need to incorporate, on a personalized way, Big Data tools that help develop new strategies into their business activities.

Bridge Mediatech, S.L. (from now on BMT), a Spanish technology company, has developed a Cloud-based Platform embedding its patented Automatic Content Recognition (ACR) technology in order to provide a richer experience to the audience. It also provides the broadcasting players with an easy to install and operate Big Data Platform to improve the engagement with their audience. It helps getting to know them better and it allows to offer customized contents tailored to their needs product and services.

After having proved the core of the technology in the worlds largest Spanish speaking broadcasting player like Televisa, its time to start thinking about large scale solution deployment and international expansion. For that reason BMT applies to this call to develop the Feasibility study needed to accomplish the technology consolidation and large scale deployment which will let BMT become the global leader in this emerging and innovative marketplace.";71429;50000;H2020-SMEINST-1-2014;SME-1;BRIDGE MEDIATECH SL;ES;;; 196405;666712;Hydrofaction;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;Resource and Cost Effective Conversion of Biomass to HydrocarbonTM Oil;1/04/2015;31/03/2017;;"The ambition for the Project is to pave-the-way for commercialization and implementation of Steeper Energy Aps (SEA) innovative hydrothermal liquefaction technology platform: HydrofactionTM.
The proprietary technology is a highly efficient method to produce renewable fuel oil with similarities to petroleum fuel oils. Timely commercialization will be achieved by bringing Hydrofaction to market via testing, scale-up and demonstration.
Based on a proven new chemical process, using renewable low-cost (non-food) feedstocks, Hydrofaction Oil can be burned in CHP applications, used a substitute for low-sulphur marine diesel or may be upgraded to diesel or jet via traditional petroleum refineries.
The Project will advance the design of the Hydrofaction technology platform and mature the Companys preparedness to attract new investment while moving the TRL level from 6 to 8: a critical step toward the commercialization of Hydrofaction. The Project objectives include adjusting the product offering to meet the needs of technology users (licensees) and their customers (oil buyers) by lowering the risks associated with the performance of future commercial plants as well as improving or modifying the quality of Hydrofaction Oil.
Within the design of the Project, Hydrofaction Oil will be produced from feedstocks provided by potential commercial partners as well as comprehensive testing of that oil at certified laboratories. Future licensees expect that the scaled demonstration plant, approximately 100 times larger than SEAs current Pilot facility or 5.000 fuel tonne export capacity, will be representative in both physical design and operations to subsequent full-scale commercial plants to be based on 50.000 fuel tonne export modules transforming large amounts of biomass residuals to Hydrofaction Oil for oil refineries to upgrade to renewable diesel.
Key milestones include advancing existing business partner/licensee/project relationships to signed LOIs and MOUs.";2631165,75;1841816;H2020-SMEINST-2-2014;SME-2;STEEPER ENERGY APS;DK;;; 196407;666741;Phasor;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;The World's first cost effective, electronically steerable, digital, low profile, phased array antenna to enable high speed satellite communications on the move;1/05/2015;31/03/2017;;"The demand for mobile communications is growing at compound rate CAGR of 61% p.a. and forecast to do so beyond 2022. Global mobile data traffic grew 81 % in 2013 and reached 1.5 Exabytes per month at the end of 2013, up from 820 petabytes per month at the end of 2012. Users now demand fast and affordable connectivity when and wherever they are. The growing use/ownership of laptops, tablet computers and larger smart phones has also led to an increasing demand for high quality content such as HD video on the move.

Current satellite communications antennas cannot fully meet this large and growing need: Mechanically steerable antennas which are bulky, heavy, require maintenance and pose considerable vehicle integration challenges. Phased arrays based on military technology are too costly for commercial applications. Existing low cost antennas trade-off the cost of the antenna against the requirement for much more expensive satellite bandwidth per Mbps transmitted. Their performance is also too limited for use in certain geographical areas (particularly at large skew angles).

The overall objective of this project therefore is to successfully refine and scale up for market readiness the worlds first cost effective, electronically steerable, digital, low profile phased antenna to enable high speed satellite communications on the move. This will enable us to gain a substantial market share in the 1.185bn Broadband Satellite Communications-on-the-Move (COTM) market and the associated antenna market which amounts to 0.39bn. Both of which are growing rapidly. We predict that we can achieve a 2.5% market share by 2020, generating total revenues of 134m and a cumulative EBITDA of 63m, creating 781 jobs. Our prototype system technology is demonstrated and proven in a relevant environment and at TRL6. This project will allow us to demonstrate the market disruptive system in an operational environment and then fully scale up the system to market readiness.";2925093,75;1516545;H2020-SMEINST-2-2014;SME-2;PHASOR SOLUTIONS LIMITED;UK;;; 196474;672768;STROBE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Sustained Release Ocular Bevacizumab for the treatment of wet acute macular degeneration;1/05/2015;31/10/2015;;"Sustained Release Ocular Bevacizumab for the treatment of wet acute macular degeneration

This feasibility study is to verify the technical and economic viability of a sustained release bevacizumab product (SR Bevacizumab) to improve the safety, cost-effectiveness and patient acceptability for the treatment of wet age-related macular degeneration (AMD). AMD is the leading cause of blindness in those aged over 50 and causes blurring, distortion and loss of central vision and almost always affects quality of life. Prototype SR Bevacizumab products will be manufactured using CriticalMix, an advanced manufacturing and processing technology developed by Critical Pharmaceuticals, which will encapsulate bevacizumab in biodegradable polymers suitable for sustained release of the drug in the eye.";71429;50000;H2020-SMEINST-1-2014;SME-1;CRITICAL PHARMACEUTICALS LIMITED;UK;;; 196477;672860;ELECTRIC_AXLE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Electric axle for hybrid / electric commercial vehicles;1/05/2015;30/09/2015;;"Silexs goal with the project is to increase its turnover, profit and size by innovation, in order to become a medium size enterprise. During the project an 8,5 -9 tons axle will be developed with integrated in-wheel electric motors, for electric/hybrid commercial vehicles (city buses, small trucks distributing products and fork lifts). Currently there are no commercially available axles designed for these vehicles, which is the novelty of the project. Vehicles using available axles, designed for combustion engines are heavier; consume more energy then necessary and contain components (propeller shaft, differential), which can be omitted in another architecture. Using the in-wheel motors ABS, ASR, retarder functions will be solved electronically. The axle will be 30% lighter then available ones, reducing vehicles energy consumption by 6-8%.
Patent search has shown that the key IPs of the project are currently not patented. Technical goal of the project is to develop, test and verify the axle and build it into a test vehicle to start field tests. Systems, based on the new axle will be 2-2500 cheaper then existing solutions. Lower price plus energy saving, i.e. lower operating costs are the two key sales arguments, which meet market demands. According to our preliminary market analyses, assuming 10% market share in the 3 market segments mentioned above, 1500-2000 axles can be sold p.a., which means 15-20 million turnover and 2,5 3,5 million profit. In Phase 1 a detailed Feasibility study will be elaborated, including technical details, project schedule, market analyses and strategy in order to co-fund Phase 2, what we estimate to 650-700 k as total project cost. Feasibility study will conclude to a business plan for different market scenarios. Investment will be evaluated by payback time and ROI. Business plan will comply with accounting standards. The project results a small contribution to increase energy efficiency and improve European competitiveness.";71429;50000;H2020-SMEINST-1-2014;SME-1;SILEX IPARI AUTOMATIZALASI ZARTKORUEN MUKODO RESZVENYTARSASAG;HU;;; 196424;671957;DEFLUG;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Development of Environmentally Friendly Flue Gas Purification Solution;1/05/2015;31/10/2015;;"The DEFLUG project will develop and commercialise a fully automatic flue gas filtration system for industrial and private customers. MyCapital O in cooperation with its scientific, technical and marketing partners will introduce a very cost-effective and environmentally friendly flue gas purification solution that is based on the companys patented substance.

The substance can be mixed with regular pure water or seawater to form a purification dilution. The cleaning of flue gases is based on chemical reaction by which the flue gases will be purified from harmful substances like NOx, SO2, CO2, particulate matter, etc. The used dilution is completely harmful to humans and the environment. MyCapitals innovative solution eliminates current problems with utilisation of waste filters and polluted water. In addition, the filtration system operates fully automatic and it has significantly lower life-cycle costs than all the alternative solutions at the market.

MyCapitals flue gas filtration systems are in first order commercialised to industrial boiler houses and large shipping vessels. Especially large market potential is seen at shipping industry. Today, of total global air emissions, shipping accounts for 18 to 30 percent of the nitrogen oxide and 9 percent of the sulphur oxides. Air pollution from international shipping accounts approximately for 50,000 premature deaths per year in Europe, at an annual cost to society of more than 58 billion according to recent scientific studies. Besides enhanced emission control of SO2 and NOx, the EU has committed to decrease maritime transport emissions 50% of 2005 levels by 2050. MyCapitals solution main advantage over alternative technologies is that the used dilution can be directed straight into the sea, diminishing the need for costly utilisation of the wastes. The innovation is also easily scalable, being suitable for large variety of ships, other industrial applications and for private households heating systems.";71429;50000;H2020-SMEINST-1-2014;SME-1;OSAUHING MY CAPITAL;EE;;; 196497;673280;PROTOCOL;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;New processing technology for colistmethate sodium, leading to improved and cost-effective formulations for pharmaceutical and veterinary markets;1/05/2015;31/10/2015;;"Colistimethate Sodium (CMS hereinafter) is a rapidly bactericidal antimicrobial agent with a significant post-antibiotic effect against multidrug resistant Gram-negative pathogens. CMS represents a reliable alternative for the treatment of life-threatening nosocomial infections but today the market supply of CMS relies on industrial processes based on freeze drying of CMS aqueous solutions. This represents outstanding energetic costs that directly affect the final price of CMS.
CIDQO is an SME founded in 2012 and its PhD staff has a wide expertise and know-how on the development and scaling-up of chemical processes, as well as on custom manufacturing of active pharmaceutical ingredients. CIDQO aims to undertake an innovation project to solve the current limitations of CMS supply, through the industrial validation of a new processing technology based on the combination of ultrafiltration and evaporation coupled to HPLC/LC-MS. The key market opportunity of the new processing technology relies on its ability to deliver a non-pyrogenic and sterile CMS formulation to be commercialized on the Pharmaceutical and Veterinary medicine markets, which will represent several advantages in terms of price and quality compared with the current commercial form.
The overall plan to reach the market needs to be defined in the short term since the innovation process is next to finish. Phase 1 of SME Instrument represents a good opportunity to get the financial support required to perform a thorough market study not only to minimize risks but also to set up a business plan for commercialization. The main objective is to perform a thorough feasibility study to verify the practical and economic viability in Pharmaceutical and Veterinary markets of the CMS form to be delivered by the new processing technology. The actual market chances that can be exploited to maximize the economic returns will be analyzed and a detailed business plan will be developed.";71429;50000;H2020-SMEINST-1-2014;SME-1;CIDQO 2012 SL;ES;;; 196431;672081;FanBrake;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;High heat dissipating Brake for heavy duty vehicles through an enabling annular disc Fan effect (FanBrake);1/06/2015;31/10/2015;;"Europes heavy goods vehicle market is a major contributor to the economy with a total production of 616,000 vehicles at a market value of 61 billion and 241,000 new registrations per year (2013). Hence, it is expected that safety of the people, goods and vehicles involved is critical. Yet, in 2011, HGVs and Lorries accounted for 1,317 fatalities, most of which were drivers.
A major factor contributing to the poor safety record of HGVs is the limited ability of their brakes to remove heat at a sufficient rate to avoid brake fade, a condition where the thermal capacity of the brake has been exceeded and the brake operates at reduced effectiveness or failure.
FanBrake aims to address these limitations through a the development of a high heat dissipating brake that will remove heat at a faster rate than brakes that are currently used, thereby improving the safety performance of HGVs.
The result of the proposed project has the potential to significantly improve safety, provide light weighting benefits and reduce cost through reduced number of brakes installed and component replacements in HGVs. Other potential applications for FanBrake include rail and construction vehicles.";71429;50000;H2020-SMEINST-1-2014;SME-1;FENNACO LTD;UK;;; 196515;673563;ENAMISS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;ENAMISS - Energetic Neutral Atoms Monitor on the International Space Station;1/05/2015;31/10/2015;;"In the frame of space weather science, a systematic monitoring of the geomagnetic activity in the inner magnetosphere plays an important role in the field of telecommunication and navigation satellite systems safety as well as safety on materials and employers within flight routes at polar latitudes. A consolidated technique for remote sensing of plasma circulation relies on Energetic Neutral Atoms (ENA) observations. However, up-to-now only dedicated mission in polar orbit collected ENA imaging, whereas continuous ENA monitoring from low altitudes is a missing task; therefore our proposal aims to develop an ENA instrument on board the International Space Station (ISS) since its peculiar orbit would allow wide-field ENA images. In this context, the Italian Space Agency agreed to provide support for what concerns the instrument allocation on the launch vehicle and its accommodation outside the ISS.
Primary goal of this phase 1 study is elaborating a business plan verifying the technological feasibility as well as the economic viability for realization of the first prototype of an ENA imager (ENAMISS), with the opportunity for the SME consortium to transfer existing knowledge into innovative solutions able to grow performance and also to establish expertise in ENA sensors where the heritage is mostly in the USA.
The main business purpose collocates in the idea to application frame creating a new standard of atomic cameras, offering the possibility to supply a user alert service (also with dedicated smartphone App) to mitigate the geomagnetic storms effects. Envisaged key markets are the space and navigation one.
The innovation of the project is mainly related to exploitation of the ISS as platform for ENA monitoring to provide an European-leaded service for Space Weather studies and related activities with the twofold benefits for the SME consortium to acquire heritage in this field and a preferential position in Europe and in the world.";71429;50000;H2020-SMEINST-1-2014;SME-1;KAYSER ITALIA SRL;IT;AMDL SRL;IT; 196378;666100;EVIDENT;SIGNED;H2020-EU.3.1.;Health;H2020;Ebola Virus Disease - correlates of protection, determinants of outcome, and clinical management;1/11/2014;31/10/2016;;"The Ebola virus disease (EVD) epidemic in West Africa is not under control. This proposal has immediate, mid-term and long-term objectives to combat the current and future EVD epidemics. Objectives with immediate impact are: (i) Providing key information needed to implement efficient convalescent plasma treatment and a toolkit to determine the suitability of plasma for treatment; (ii) Providing key information needed to estimate the efficacy of experimental vaccines, including correlates of protection at T cell level; (iii) Improving supportive treatment of patients and reducing hospital case fatality rate by providing information on biomarkers and relevant co-infections; (iv) Monitoring development of mutations in Ebola virus (EBOV) genomes during the epidemic and enhancing our preparedness to determine the relevance of these changes in experimental systems; and (v) Protecting health care workers and communities by providing information on virus shedding in body fluids and estimation of infectiousness in various stages of EVD. Objectives with mid to long-term impact are: (i) Provide information on pathophysiological changes and immunological determinants to infer new immunotherapeutic strategies for treatment of EVD; and (ii) Strengthening cooperation of biosafety level 4 (BSL-4) facilities and building a pan-European research area in the field of highly pathogenic viruses as envisaged in the European Research Infrastructure on Highly Pathogenic Agents project. The concept of EVIDENT is to scientifically exploit specimens collected from EVD patients during outbreak response and field research. We will use state-of-the-art methodologies within the EU BSL-4 facilities to gather new and outbreak-relevant knowledge on B and T cell immunology, biomarkers, virus evolution, virulence determinants, and transmission of EBOV. The consortium contributes to the outbreak response since March 2014 and is competent to implement a project in the outbreak area.";1759325,25;1759325,25;H2020-Adhoc-2014-20;RIA;BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN;DE;"EUROPEAN RESEARCH AND PROJECT OFFICE GMBH;ARTSEN ZONDER GRENZEN (MEDECINS SANS FRONTIERES NEDERLAND) VERENIGING;BUNDESMINISTERIUM DER VERTEIDIGUNG;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;Department of Health;ROBERT KOCH-INSTITUT;ISTITUTO NAZIONALE PER LE MALATTIEINFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERESCIENTIFICO;UNIVERZA V LJUBLJANI;PHILIPPS UNIVERSITAET MARBURG;ORSZAGOS EPIDEMIOLOGIAI KOZPONT";"DE;NL;FR;UK;IT;SI;HU"; 196430;672077;Libralato;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;"Libralato rotary engine; a game-change for cost competitive gasoline engines and plug-in hybrid cars.";1/05/2015;31/10/2015;;"The Libralato engine is the worlds first one stroke rotary Atkinson cycle engine, completing all of the engine phases in parallel in each rotation. It has a completely new thermodynamic cycle which is predicted to achieve around 40% efficiency using gasoline. This is achieved because of its asymmetrical expansion and compression volumes and because it does not need to convert the reciprocating motion of pistons into the rotational motion of the output shaft. The Libralato engine has only four principal moving parts: two rotors fixed by their own bearing, connected by a sliding vane and a rotating exhaust. It has no need for conventional cylinders, pistons, con-rods, crankshafts, valve trains and cam shafts. The engine is tuned for lean burn combustion, with high and constant levels of torque, very low vibration and very low exhaust temperature and noise reducing fuel consumption by two thirds and CO2 emissions by 50%.
The proposed innovation project intends to; demonstrate and validate the performance of the engine in an operational environment; run a fully operation commercial pilot with fleet test; industrialisation of Libralato engine for high volume production; scaling of production capability for up to 20k units.";71429;50000;H2020-SMEINST-1-2014;SME-1;LIBRALATO LTD;UK;ENGINE DEVELOPMENTS LTD;UK; 196517;673601;Elistair;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Bringing unlimited autonomy to Civilian Drones : PULSE, an Intelligent Tethered Power Supply.;1/05/2015;31/10/2015;;"Drone operators are suffering from a major weakness of this technology : autonomy. The average time of flight is around 15 minutes, which reduces considerably the productivity and the potential applications of unmanned aerial vehicles. Our company Elistair brings unlimited autonomy to civilian drones. We design and manufacture tethered power supply for drones.

Our project is to develop the first intelligent tethered power supply system for civilian drones : compatible with 95% of civilians multicopter drones, it will bring unlimited power from the ground station to drones through a extremely lightweight micro-tether. This tether will also include secured and unjammable high speed data transfer. The data will be displayed and processed in real-time thanks to a computer at the ground station. Thanks to this tether, the drone is not considered as a drone by civil aviation laws (secured operations).

We target three applications : structural inspections, aerial surveillance (response forces, firemen etc...), aerial broadcasting for live events, and telecommunications.

The objectives of our innovation project are:
to assess the commercial and technical feasibility for our tethered system PULSE.
to define the utmost performing solution and new technical design of the tether power supply system, with the inclusion of the data transfer function.
to lead an intellectual property study in order to define an IP strategy. This will help us to address foreign markets.
to rapidly prototype the final system.

Our company is located in Lyon and we are a team of five (mostly engineers). We are currently prototyping and are working with industrial beta testers (Thals, Bouygues Energie et Services, Euronews, Red Bird...). Our first prototype is focused on the power transmission.";71429;50000;H2020-SMEINST-1-2014;SME-1;ELISTAIR;FR;;; 196391;666435;DEVULC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Novel Devulcanization Machine for Industrial and Tyre Rubber Recycling;1/04/2015;31/03/2017;;"DEVULC is a novel rubber recycling technology based on a cost-effective devulcanization process which uses supercritical CO2 instead of chemical solvents banned by the REACH directive. DEVULC can reclaim valuable manufacturing scrap such as tyre rubber crumb, EPDM (ethylene propylene diene monomer), and Silicone rubber, and it can deal with spent and used rubber materials (rubber seals, used tyres, etc.) that are sufficiently clean, and with waste (scrap cut-off) when new rubber products are manufactured create a new 100% recycled material: DEVULC TPV.
The process is socially responsible, environmentally sustainable and economically viable. No chemical solvents are used, devulcanization takes 1 min, and there is a 99% crumb conservation. DEVULC TPV is a versatile material that can be engineered to provide a range of properties. It has a consistent quality and can be incorporated in up to 25% content for the production of new rubber products.
DEVULC will positively impact the industrial rubber and the tyre rubber markets. It will develop a recycling method which complies with the environmental standards imposed in the EU. It results in a recycled material fully compliant with the restrictive standards for automotive industry.
It will impact large rubber manufacturers which will built inside their installations a DEVULC recycling plant working in continuous with the rubber production chain for the recycling of the scrap cut-offs. The recycled material could be entyrely used by this large company.
Plants located near a pole of rubber producers, to jointly manage all residues, can benefit from the scale-size effect. Technically, different lines could be operated for different rubber types. Finally, waste sorting plants could benefit from a DEVULC plant built in their facilities. With this installations, rubber cemeteries could become sources of recycled rubber, turning rubber waste management into an economically profitable activity.";2425337,5;1697736,25;H2020-SMEINST-2-2014;SME-2;PHENIX-TECHNOLOGIES;FR;;; 196503;673416;SWeetLight;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Suturing with Light;1/05/2015;31/10/2015;;"'The proponents aim to establish an international leading company in the field of innovative medical devices for laser eye surgery, keratoplasty in particular (cornea transplantation): the objective is to become pioneers in the field of ophthalmic surgery with a novel surgical technique of cornea laser welding for keratoplasty called SWeetLight (suturing with light). The specific aim is realise a medical device able to:
improve the quality and the overall precision of the keratoplasty,
standardize the surgical treatment by enhancing surgeon skills using robotic platform adopting collaborative control system to optimize the welding task of corneal wounds,
strongly reduce the risk of rejection and also of astigmatism, also respecting and preserving the donors cornea,
reduce the duration of the post-hospitalization phase: faster and safer visual recovery (fast back to work),
reduce the dependency of the intervention from the surgeon skills.
From business point of view the objective is to reach the Break Even Point (BEP) at the end of year #2, and a value of revenues of 4 million at the end of year #5.'";71429;50000;H2020-SMEINST-1-2014;SME-1;EKYMED SPA*;IT;FASTENICA SRL;IT; 196390;666425;ECO-SILENTWOOD;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014;H2020;Cost competitive eco-friendly and acoustic wooden doors for indoor applications;1/05/2015;30/04/2017;;"Windows and doors are key components to ensure the noise insulation of a room. Some sectors, looks for noise reduction solutions in indoor doors, in order to ensure the comfort. That is the case of (a) Medical applications: 35dBA of S.R.I. would cover most of customer and regulatory demands; (b) Hotel door applications (customers demands 34dBA); Dwelling entrances (customers demand over 35-38dB). We are going to define the exploitation strategies to ensure a 5% market share of the European doors market for dwelling building, education and sanitation centres by year 5, with a total cumulated turnover of 23.8 million.
To meet this goal we wil launch a a product that ensures 37 dBA for doors, with a maximum thickness of 45 mm and maximum wight of 70kg.. Current prototypes of our technology reach even 42 dBA of SRI. Our wood door is fire resistance at EI30 (meaning the door can keep its integrity at least 30 minutes in case of fire) with a maximum door thickness of 45 mm and a maximum weight of 70 kg.
Besides, and looking for complying with national eco-bales, our doors are based on eco-friendly materials: (a) wood wool instead of rock wool, (b) 100% recycled acoustic underlay manufactured from a combination of cork granules and rubber crumb or by a wood fibre and cork material instead of promasound and (c) recycled plastic/wood composite (instead of plastic/wood composite). This will give us access to a new market nice: the green building sector.
To be unique in the market, our door must ensure a cost under 650 , therefore we will establish a LEAN manufacturing strategy that will allow for a15% cost reduction with respect to the SILENTWOOD proposed solution (actual prices is around 800 to 900 per door).";1881186,5;1316829,95;H2020-SMEINST-2-2014;SME-2;PADO-ELEMENTEBAU HOLZ- UND KUNSTSTOFF GMBH;DE;"LUALDI SPA;MELU, mizarstvo, d.o.o.";"IT;SI"; 196462;672638;XER-HSA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Engineered materials scale-up at industrial level for highest energy density ultracapacitors;1/06/2015;30/11/2015;;"The current proposal aims to analyze the feasibility of the Xerolutions S.L. business project, which is focus on mobile energy sources, in particular on the electrochemical energy storage systems, also known as super-capacitor (SC) or ultra-capacitor (UC). Electrochemical energy storage systems will constitute an essential element in the development of sustainable energy technologies, considering that the SCs can deliver energy quickly, can be recharged in seconds, and can withstand cold temperatures, shocks or vibrations. They also contain earth-abundant and nontoxic materials, so they are much environmentally friendly than today's batteries are. However, to take advantage of all opportunities that market offers, it is necessary that some technical capabilities of the SCs improve. While the currently available energy density is acceptable for applications such as emergency doors, memory backup and so on, limited energy density is widely perceived as the main impediment to growth of its sustainable energy applications. Therefore, much research and development has focussed on increasing SCs energy density at assumable price.
Xerolutions designs and manufactures engineered carbon porous materials for SCs. Our Technology Platform controls the porosity structure adapting the size of pores for electrolytes ions dimensions to ensure high capacitance values and good charge propagations, especially at high loads. In this way Xerolutions materials achieve to increase the energy density of SCs while maintaining their high power capability, therefore the total device cost per unit of energy stored is reduced. Xerolutions has developed XER-HSA products range that is formed by open porosity carbons materials especially suitable to SCs which use different types of electrolytes. At present, Xerolutions has a plant with a production capacity in-batch of about a few kilos per day, so we would need to scale up the process and to automate each production step.";71429;50000;H2020-SMEINST-1-2014;SME-1;XEROLUTIONS SL;ES;;; 196409;666788;EBMPerform;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014;H2020;High-quality, high-speed EBM 3D printing by the integration of high-performance electron sources;1/08/2015;31/07/2017;;"Background:
Production of high integrity components in Europe must use smart manufacturing methods to be efficient in use of scarce materials and other resources, and must ensure its environmental impact is minimised. Advanced manufacturing techniques, such as metal powder bed 3D printing, can ensure that production of aerospace parts is carried out with resource efficiency. However, such techniques are today struggling with technical and reliability consistency for use in production. Arcam is a Swedish SME who uniquely design and supply electron beam additive manufacturing (EBM) machines.

Objective:
The aim of this work is to overcome key obstacles concerning future requirements for EBM 3D printing for production of aerospace parts through the integration of two enabling technologies. The work will develop and integrate a novel plasma cathode electron source with an EBM machine focusing on realising the enhanced capabilities of low maintenance, consistent manufacturing performance and higher productivity. Also, development and integration of an array probe device will provide quantified quality assurance of machine manufacturing readiness. The key research challenges will be the design of the electron source and optics and the development of new build procedures making best use of the new source.

Expected Results
The verified design of a plasma cathode electron source will enable high integrity 3D printing of metal parts. Arcam will supply equipment with this technology to large industrial companies for efficient production of parts. The equipment will enable the wider adoption of EBM leading to efficient use of materials particularly strategic titanium alloys and nickel based super alloys at first. Increased equipment sales are expected to boost Arcams growth over the next 5-10 years leading to faster adoption of 3D printing for large scale production. The results will be disseminated to existing and potential end-user clients in aerospace and other sectors.";2394400;1648035;H2020-SMEINST-2-2014;SME-2;ARCAM AB;SE;;; 196479;672881;GT WHR system;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Green Turbine WHR System;1/06/2015;30/11/2015;;A Waste Heat Recovery System that converts flue gasses of a diesel-, gas- or fuel cell engine into electricity.;71429;50000;H2020-SMEINST-1-2014;SME-1;BEPART BV;NL;;; 196459;672619;MAP-Detector;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Development of a novel low dose, high resolution, high contrast X-ray detector for medical applications to improve patient diagnoses and reduce the risk of X-radiation induced cancer;1/05/2015;31/10/2015;;"X-ray imaging is a valuable medical diagnostic technique, accounting for 47% of the medical imaging market in 2011. However, current X-ray detection technology exposes patients to increased risk of developing cancer with research in 13 developing countries showing that exposure to X-ray detection technology accounted for 06% to 18% of the cancer cases. X-ray detector manufacturers are thus keenly seeking technology that would reduce radiation exposure (dose) to patients whilst offering superior material discrimination for earlier detection and treatment of clinical cases.
As IBEX, we have developed and patented an innovative X-ray detection technology incorporating our unique Multi Absorption Plate (MAP). Our technology significantly surpasses current solutions based on cadmium telluride (CdTe) as it offers potential dose reduction of >50% plus enhanced materials discrimination. MAP-Detector offers a disruptive X-ray detector that will leverage the MAP technology in both retrofitted and new build X-ray detectors for medical applications.
The global medical diagnostic imaging market is expected to grow from 21.4bn in 2012 to 27.4bn by 2017, with X-ray and CT imaging equipment having a 50%/13.1bn share in 2017. Within this segment, the X-ray imaging detector market is estimated at 2.0bn. Our technology will be compatible with the leading X-ray inspection systems creating significant market potential. Our initial target segments within the medical industry are fluoroscopy and mammography with dosage reduction being far more important for the former and materials discrimination an essential requirement for the latter.
In Phase 1 we will thoroughly analyse the market to more clearly define our route to market and requirements for rapid market uptake. This will culminate in the drafting of a more detailed operational business plan.
In Phase 2 we intend to conduct clinical trials and achieve certification for our technology in preparation for market introduction.";71429;50000;H2020-SMEINST-1-2014;SME-1;IBEX INNOVATIONS LTD;UK;;; 196363;665651;HYMEDNA;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Hypermethylated DNA detection using NanoGaps;1/10/2015;30/09/2016;;"HYMEDNA prepares commercialization of very sensitive point-of-care biosensors for early-stage cancer detection based on the electrical detection of hypermethylated DNA (hmDNA) inside nanogaps.
Only recently the awareness has risen that local hypermethylation of DNA provides a generic marker for a wide range of cancers. A robust, simple and cheap method for detecting hmDNA at low concentrations in blood, urine or faeces would be a major step forward in the early-stage detection of cancer. Existing hmDNA detection relies on fluorescent read-out, which requires dedicated laboratory handling.
Our technology is based on electrodes separated by a tunable nanogap. hmDNA is trapped and highly concentrated in between the electrodes using methyl binding domain (MBD) proteins. MBD binds specifically to methylated CpG sequences and thus provides the direct recognition of the targeted methylated moieties, contrasting existing DNA detection methods which commonly employ DNA (or PNA) oligos and rely on sequence specificity. After target binding, the conductivity of the trapped hmDNA is enhanced, for which we provide alternative routes. The detection step is formed by a simple measurement of the electrical conduction between the electrodes. As our detection scheme relies on completely turning on the conduction instead of only modulating it (as in other electrical detection schemes), an exceptionally high sensitivity is expected. As the most competitive advantages we identify (1) high selectivity (specific chemistry) and sensitivity (on-off effect), (2) simple, scalable device concept, (3) robustness against environment, (4) small size (allowing for implementation in a bioassay device for multiple target molecules), and (5) low cost price.";149578,75;149578,75;ERC-2014-PoC;ERC-POC;UNIVERSITEIT TWENTE;NL;;; 196392;666449;CarNet;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Rapid Data Communication Network for Connected Cars;1/04/2015;31/03/2018;;"Demand for data in cars has grown at a rapid rate. Connected cars now want to communicate between the different areas of the car to understand the status of the car, the environment around it and then communicate this information to the driver. Many Advanced Driver Assisted System applications wish to make use of this data to support the driver to drive safely and to save lives.

However, current in-car data communications networks cannot supply this day in a fast, reliable way so that it can be used. The physical environment of the car is challenging, with vibrations, heat and Electro Magnetic interference all meaning that traditional communications networks are unsuitable. They are also not capable of reaching above speeds of 150Mbps, meaning all information is too slow to be useful.

KDPOF has developed and patented a breakthrough low-cost technology which allows data transmission at rates of up to 1Gbps. Furthermore, as this technology uses Plastic Optical Fiber, it overcomes all the challenges of the in-car environment. KDPOF have recently launched this product for the consumer and professional markets.

The CarNet project aims to support KDPOF to adjust, test and demonstrate the benefits of KDPOFs Giga technology to the Automotive market. As this market is complex, with a long product development process, the CarNet project will also look to understand fully the business strategy to ensure that the products commercial potential is maximized and to ensure that KDPOF is at the forefront of developing the standards that will shape the future in-car data communications market.

As a result of this project, KDPOF will grow considerably, doubling their employees by five years after the project and earning a return on investment of over 80%. It will also reduce the costs of in-car data communication networks and improve the competitiveness of the European Automobile sector in general, and the in-car data and ADAS sector in particular.";1917731;1342411,7;H2020-SMEINST-2-2014;SME-2;KNOWLEDGE DEVELOPMENT FOR POF SL;ES;;; 196500;673383;PREKIND;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;PreEclampsia diagnosis by Early Kidney Injury Detection;1/05/2015;31/07/2015;;"Health Challenge:
PreEclampsia (PE) claims the lives of 75,000 women annually and the 6,000,000\ surviving mothers will have an increased risk of cardiovascular disease for the rest of their life. PE accounts for over 500,000 infant deaths worldwide every year1; and for the millions of babies that survive, they too will go on to have increased risk of a variety of health issues. PE is a syndrome that develops during pregnancy but presents no clinical symptoms during most of the pregnancy and is therefore currently complex to diagnose.

Business Challenge:
With an annual spend of over 31Billion in direct costs in the developed world alone, the provision of antenatal care to pregnant women has a significant impact on health care budgets; dealing with the immediate consequences of PE form an important contribution to this cost. The Preelampsia foundation (http://www.preeclampsia.org/) estimates the annual cost of PE is more than $7billion in the US.

InformBio Business Innovation:
InformBio (IB) has licensed pioneering research by Dr.Vesna Garovic of the Mayo Clinic, USA. The technology has identified podocyte specific biomarkers in urine that indicate ongoing renal damage and which allow for a sub-clinical diagnosis for PE. The key biomarker, podocin, has demonstrated exceptional sensitivity and specificity and can diagnose the disease up to 3 months before clinical symptoms emerge3. InformBio are currently working to develop flow cytometry and research use only (RUO) ELISA assays for the biomarker.
InformBios ambition is to be the world leader in early pregnancy prognostic tests, offering the most innovative, cost effective solutions to predict pregnancy complications.

Phase 1 proposal:
To conduct a feasibility study to support the development of a detailed business plan for the introduction of a PE diagnostic test.";71429;50000;H2020-SMEINST-1-2014;SME-1;INFORM BIOSCIENCE LIMITED;IE;;; 196478;672869;Ecosheet-PRO;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;An Environmentally-Friendly Alternative to Plywood made from Co-mingled Waste Plastic;1/05/2015;31/10/2015;;"At present, 50% of all EU plastic waste still ends up in landfill. This is in spite of the European Chemical Industry Council (CEFIC) target of Zero Plastic to Landfill 2020 to help Europe achieve the targets of Council Directive 1999/31/EC of halving landfill waste from 1995 figures. Unfortunately, the majority of plastic waste within the EU are in the co-mingled contaminated category which are notoriously difficult to separate or recycle. Furthermore, also polluting EU landfills is end of life plywood. More than 300k tonnes of plywood waste is generated yearly most of which end up in landfill. Plywood contains toxic resins, adhesives which leach into the soil and are damaging to the environment.

The aim of this innovation project is to bring to technology maturity and market readiness an environmentally friendly, cost effective, alternative to plywood made from low grade mixed-plastic waste, specifically for the construction industry. By so doing, we will cut down on the global demand for plywood (3 million m3 in 2013 in Europe alone - globalwood.org), and thereby stem the tide of global deforestation. At the same time will will divert a problematic waste stream (co-mingled, mixed plastic waste) from landfill and transform it into a valuable feedstock for added value products.

At Environmental Technology Evolution Limited, (ETE) we have a strong ambition to continue to lead the industry by developing and commercialising a much improved version of our already multi award winning Ecosheet (the previous generation of proposed product).

Ecosheet-PRO will meet the construction industrys need for an environmentally friendly alternative to plywood. The ability to be recycled at end of life makes Ecosheet-PRO unique. This project would re-define a 9bn global plywood market and help Europe meet its plastic recycling targets. Ecosheet-PRO is expected to create 120 jobs and generate annual revenue of over 77.1m, 6 years post project completion.";71429;50000;H2020-SMEINST-1-2014;SME-1;ENVIRONMENTAL TECHNOLOGY EVOLUTION LTD;UK;;; 196501;673403;WORLDTIMING;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;ULTRA ACCURATE WORLD TIMING SERVICES;1/06/2015;30/11/2015;;"The project aims at distributing ultra-accurate and traceable timing through optical fibres. The goal is to provide traceable, accurate and cost-effective timing information for the Galileo Time System and for customers requiring highly dependable distributed synchronization applications. The target customers include government authorities as European Galileo Agency (for the Galileo surface segment) and customers in Telecom, Smart-Grid, stock market (high frequency trading) and highly accurate positioning markets (conventionally dependent on satellite signals). The use of terrestrial timing distribution allows National Metrology Institutes (NMIs) in charge of Galileo Time Validation Facility to compare their clocks and steer to UTC, maximizing the traceability of Galileo System Time and enhancing its accuracy. In addition, this allows deploying a terrestrial time network for industrial applications, traceable with respect to UTC and Galileo, robust against satellite signal vulnerability problems and providing redundant time services for critical infrastructures.

This is possible with the emergent White Rabbit (WR) solution which is a sub-nanosecond accurate timing technology originally born at CERN for scientific facilities. WR is an extension of the standard Ethernet based on time distribution standards. As an extension of Ethernet, it can be easily integrated with existing communication networks at negligible bandwidth cost and can distribute time and frequency signals with 100 ps accuracy over distances longer than 1000 Km.

The purpose of this project is to confirm a business plan and develop in detail an appropriate strategy to penetrate the market. This includes a proper market analysis (existing markets and emergent applications), partnership strategies and concrete commercialization plan for those sectors. In phase 1, we will focus on exploring the specific characteristics of different potential customers and final application sectors.";71429;50000;H2020-SMEINST-1-2014;SME-1;SEVEN SOLUTIONS SL;ES;;; 196502;673405;XPRESSO;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Breakthrough gene expression search engine for cost reduction and significantly increased use of open data in drug discovery.;1/05/2015;31/10/2015;;Breakthrough gene expression search engine for cost reduction and significantly increased use of open data in drug discovery. We are putting the power of genetic data analytics into the cloud and providing this as an easy to access service to biologists via a search engine. The challenge today is that as the field of sequencing is developing at a rapid pace and the amount of genetic data is exploding, nobody really can analyze all that data and pull it up when needed for making informed decision in the field of drug development and life science research. We are seizing this business opportunity through our competitive edge by creating an easily usable cloud-based gene expression search engine on top of publicly available datasets that have been analyzed and indexed by our advanced algorithms. This allows for providing unexpected discoveries in the field of drug discovery at a significantly reduced rate and insight, which has not been possible before.?;71429;50000;H2020-SMEINST-1-2014;SME-1;MEDICAL TECHNOLOGY GROUP OU;EE;;; 196464;672653;ProTreaT;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;FEASIBILITY ASSESSMENT OF THE GREEN ProTreaT TECHNOLOGY FOR PROTEIN-BASED, NATURAL REMOVAL OF HEAVY METALS FROM WATER AND WASTEWATER;1/06/2015;31/03/2016;;ProTreaT is a 100% natural, cost-effective, resource efficient, multi-purpose and multi-beneficial solution for the removal of heavy metals from water, simultaneously benefitting environmental, social and economic objectives. The innovation of ProTreaT lies in the use of fish-derived proteins to thoroughly remove HM and other pollutants, such as bacteria and viruses, from primary water (i.e. suitable for human consumption and/or suitable for agriculture/breeding) and from industrial process and wastewater, and, therefore, from the food-chain.;71429;50000;H2020-SMEINST-1-2014;SME-1;SACECCAV SPA;IT;;; 196348;665607;HITCHIPDIAG;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic Glycosaminoglycans;1/04/2015;30/09/2016;;"Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic Glycosaminoglycans
Heparin, a complex glycosaminoglycan (GAG) carbohydrate, is the most commonly used anticoagulant. Twelve million patients in the EU are treated annually for conditions including acute coronary syndrome, deep-vein thrombosis and cardiopulmonary bypass surgery. Heparin-induced thrombocytopenia (HIT) is a dangerous adverse side effect of heparin administration. HIT-II develops after major surgery or dialysis and results in infarction, multi-organ failure and 20% mortality. In Europe 100,000 patients develop HIT-II annually.
Currently, two HIT-II diagnostics are available. The HIPA and MAIPA tests detect antibodies against a complex of heparin and platelet factor 4 but suffer from low diagnostic specificity and accuracy. Faster, more reliable and cheaper methods to diagnose complications after administration of heparin are needed to improve patient wellbeing and reduce costs.
The ERC Advanced grant AUTOHEPARIN yielded an instrument for the automated assembly of defined oligosaccharides. GAG glycan microarrays were produced by printing GAG oligosaccharides onto surfaces and used to screen patient blood. Specific glycan markers of high diagnostic value were discovered to detected HIT-II within minutes and reliabilities well above existing tests.
The overall goal of the project is to establish the business model for a company that will focus on the production of GAG glycan arrays as HIT diagnostic. Specific activities include: 1) Development of standard protocols to detect HIT-II using GAG glycan microarray; 2) Plan and cost structure for GAG arrays production; 3) Analysis of the IP space and development of an IP strategy; 4) Evaluate potential markets and establish basis for commercial discussion with potential customers; 5) Prepare business plan for discussions with investors; 6) Incorporate company to commercialize GAG arrays as HIT diagnostic";147094;147094;ERC-2014-PoC;ERC-POC;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 196463;672641;ADHESION;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Development of new biotech AdvanceD materials based on Hyaluronic acid and nanoparticlEs to prevent Surgical adhesIons and pOst surgical infectionNs;1/05/2015;31/10/2015;;"The aim of the ADHESION Project is to strengthen the anti-adhesion and anti-bacterial characteristics of a NOVAGENIT proprietary product (DAC), by tuning and validating a new more competitive solution targeted to the orthopaedic and cardiovascular surgery. NOVAGENIT will take the opportunity to expand its own business in the anti-adhesion market by taking advantage of the intrinsic barrier effect of the DAC hydrogel. A new formulation of the DAC product will add an anti-bacterial power to the anti-fouling/anti-adhesion intrinsic action. This could be due to a combination of silver nano-particles and to Vitamin C added to the derivatized hyaluronan based gel original formulation. The new formulation, comprising a lyophilized membrane, will increase the usability for the end user, and will prolong the shelf life of the biotech, advanced material product.NOVAGENIT intends to address both the adhesion and infection issues, as it is a complete novelty in the market of anti-adhesion products. Specifically the business opportunity consists in the combination of the three key product features (anti-fouling, antibiotic and usability) into a novel product not yet market available, and to target two surgery markets (cardiovascular and orthopaedic ones) in order to generate the appropriate return on the investment.
This phase 1 consists in the feasibility study devoted to assess the economic/technological viability of the innovative idea and to generate its business plan. It will be followed by a phase 2 where the product will be industrialized and make ready for sales through a targeted marketing plan. The envisaged advantage for the European Health-care system from the results of the ADHESION Project is to spare the costs of re-interventions, both for the post-surgical adhesions (about 2 billion Euros/year), and the post-surgical infections (about 3 to 5 billion Euros/year). Future opportunities of this product on different markets will be exploited.";71429;50000;H2020-SMEINST-1-2014;SME-1;NOVAGENIT SRL;IT;;; 196444;672444;CLINISC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of pCO2 sensor system for ischemia detection;1/05/2015;31/10/2015;;"Sensocure has developed and patented an innovative biomedical CO2 sensor (IscAlert) designed for the earliest possible detection of ischemia. Ischemia is a condition where the cells do not get enough oxygen to survive because of inadequate blood supply. Ischemia occurs in the form of myocardial infarction, stroke or complications after operations and accidents, and is considered the most common disease and cause of death in the Western world.
This novel mass-manufacturable biosensor for ischemia detection will make an important contribution to improved medical care for the population. The long-term aim is to reduce morbidity and mortality, and thereby cost of care, for ischemia related diseases. It fits well into current medical practice by giving improved patient outcome and therefore substantially reduces healthcare costs by lowering the need for e.g. intensive care.
The feasibility study will be used to plan the clinical testing of the IscAlert sensor on human patients. Clinical testing will be organized in cooperation with Oslo University Hospital and up to five European hospitals. During the feasibility study Sensocure will establish the legal framework needed for the clinical testing. The result of this work will be a detailed clinical test plan describing the kind of surgery to be undertaken, the clinics to be used, the number and kind of human patients to be addressed, the legal approval procedures and a time schedule for the said tests.
The business plan to be elaborated in the feasibility study will define the various market segments and define pros and cons for using specific markets for the launch of the IscAlert product. The initial markets will be identified through the networks of hospitals involved in the above clinical tests. Following these introductory markets a network of European distributors will be established. The distributors will be identified among medical diagnostic equipment suppliers.";71429;50000;H2020-SMEINST-1-2014;SME-1;SENSOCURE AS;NO;;; 196375;666085;EbolaVac;SIGNED;H2020-EU.3.1.;Health;H2020;Development of a Chimpanzee Adenovirus Type 3 Ebolavirus Zaire Vaccine;7/10/2014;6/10/2017;;"The first Ebolavirus Zaire (EBOV) outbreak of 2014 was declared on 22 March in Guinea. As of 30 September 2014, the World Health Organization (WHO) reports the total number of cases in the current outbreak of Ebola virus disease (EVD) in West Africa at 7470, with 3431 deaths. The US Centers for Disease Control and Prevention states that the number of cases is currently doubling every 20 days and estimates the true number of cases at 2.5 times higher than that reported. Countries that have been affected are Guinea, Liberia, Nigeria, Senegal and Sierra Leone. Ten percent of fatalities have occurred among front line health care workers attempting to contain the epidemic. On 7 August 2014, the WHO requested that GSK fully engage in WHO-coordinated efforts to test, license and make available safe and effective Ebola interventions to assist in the control of the outbreak.
Taking into account the early stage of development, EbolaVac seeks to accelerate the clinical development of the GSK chimpanzee adenovirus type 3 Ebolavirus Zaire (ChAd3-EBO Z) vaccine candidate to make the vaccine available to frontline health care workers at risk and to be used in the containment of EBOV outbreaks.
The project specifically aims to: (i) complete Phase 1 development of the ChAd3-EBO Z vaccine by supporting a clinical study conducted in Lausanne, Switzerland (WP2); (ii) evaluate the ChAd3-EBO Z vaccine in Phase 2 testing on adults and children at established clinical study centers in West Africa outside the current most heavily affected countries of Guinea, Sierra Leone, and Liberia (WP3); (iii) investigate immunological effects of vaccination and the effect of booster vaccination (WP4) and (iv) centrally manage and analyse clinical study data (WP5).
Besides using an innovative vaccine technology, much of the innovation of this program will reside in its capacity to implement vaccine evaluation under significant time pressure and complex logistical challenges while maintaining appropriate quality standards.";22055090,88;15153216;H2020-Adhoc-2014-20;RIA;GlaxoSmithKline Biologicals S.A;BE;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS;BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN";"UK;CH;DE"; 196447;672467;CLAYMBAR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Injected Moulded barriers for cost effective food packaging;1/05/2015;31/10/2015;;"Our company, MPG Manifattura Plastica S.p.A., is a well-established Italian company (15M turnover), specialised in thermoformed and injected packaging for food industry (e.g. ice-cream, powedered food, cheese). With more than 30 years experience, our philosophy is to sell not only a product but a complete service to our customers (Heinz, Nestl, Unilever). For this purpose, our R&D team keeps developing new products to better satisfy the clients requirements.
This has led us to the development of CLAYMBAR, a new nanoclay-polymer based container, produced by injection moulding, designed to address our customers needs in terms of price, shelf stability and life.
By offering our customers the needed packaging solutions to increase their competitivity and accelerate their growth -, we will broaden our product portfolio of thermoformed and injected moulded rigid plastics (\49% of turnover after 5 years). Our partner, Color System S.P.A., is one of the leading companies in the production of masterbatches. Our partnership with CS has been develop through several industrial projects as a masterbatches provider and they will consolidate their commercial relationship with us through the CLAYMBAR project being the main partner as masterbatch supplier, multiplying by 3 their revenues by 2022.";71429;50000;H2020-SMEINST-1-2014;SME-1;M.P.G. MANIFATTURA PLASTICA SPA;IT;COLOR SYSTEM SPA;IT; 196416;671741;ETA4B;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Energy Trusted Advisor for Buildings;1/05/2015;31/10/2015;;"ETA4B (Energy Trusted Advisor for Buildings) project promotes the development of an embedded energy optimization system collaborating with existing devices, providing citizens with innovative applications and services in the field of energy efficiency of buildings, making home more smart.
The solution includes a multi-protocol electronic unit to be easily installed in houses and small buildings, providing an open-framework web-based platform with energy-related data flow for supporting the decision making process for end users. Benefits for users are in terms of energy saving (cheaper bills), CO2 emissions reduction and, for the ones being prosumers (energy users that also produce energy in their buildings), low production costs and higher profits. For Tera Srl, the challenge is to enter in the energy efficiency market thus enhancing companys profitability. The main customers will be prosumers, addressed through an innovative commercial approach, based on web applications managed by skilled companies selling a modular and scalable service, rather than a device that will be introduced in the energy efficiency market for small buildings. Strong innovation also lies in the combination of automatic SW updating capability at front-end (no needs for maintenance and ease of use) and powerful reasoning engines at back-end. These SW engines are based on energy-model calculations and big-data like algorithms, running both on private and public data-base (open-data), delivering customized performance indexes to the users.
To demonstrate the feasibility of ETA4B, Phase 1 activities will focus on specific components such as target market, partner search, value proposition, compliance to cutting-edge standards and development platforms, financial sustainability and business model. ETA4B responds to EU challenges concerning the market uptake of a sustainable solution, a new system for energy efficiency in buildings, seizing the European and global markets.";71429;50000;H2020-SMEINST-1-2014;SME-1;TERA SRL;IT;;; 196485;672962;MICROBAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Wireless devices for smart energy management systems;1/05/2015;31/10/2015;;"There is a growing need for smart energy-efficient homes, offices and industrial plants, and this need is increasingly being supported by legislation. Hence there is a growing market for technologies to enable this, through the deployment of smart metering as well as intelligent heating, ventilation, lighting, and monitoring control systems. To address this market, a new class of low-power wireless protocols has been developed for the automation and control of the above systems.
To date, wireless home and building automation systems that employ such protocols have seen limited adoption, despite the technology being widely available, mainly because conventional semiconductor radio architectures are unable to fulfill the market need of whole-house coverage and ultra-low power consumption while using inexpensive semiconductor technology.
Cascoda's patented technology is unique in that it delivers standards-based radio communication with whole-house coverage, high data-link reliability and ultra-low power consumption, while using inexpensive CMOS semiconductor technology.
The objective of this project is to investigate the best fit for Cascodas technology with manufacturers energy management systems, and to develop an appropriate customer evaluation kit and a high-level protocol stack for the target application. Together, these items will form a solution with which such manufacturers can quickly and easily integrate Cascodas technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;CASCODA LIMITED;UK;;; 196488;673072;PANOSTICS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;The AA2-Ratio: A Novel Diagnostic Biomarker for Primary Aldosteronism;1/04/2015;31/08/2015;;"PANOSTICS comprises the validation and clinical implementation of a versatile and cost effective diagnostic blood test for the detection of primary aldosteronism (PA) among hypertensive patients. The Aldosterone-to-Angiotensin II-Ratio (AA2-Ratio) is a mass spectrometry based diagnostic biomarker for PA. We are planning to sell this diagnostic blood test to clinical institutions in a fee-for-service business model. Our vision is to build up a European network of qualified fee-for-service laboratories focused on hypertension-associated biomarkers. The market entry for the AA2-Ratio is planned via a subsidiary laboratory in Germany. Full commercialization of the AA2-Ratio shall be achieved by implementation into standard clinical practice for the classification and treatment of resistant hypertension.
Hypertension has been clearly shown to be the most important cause of morbidity and mortality worldwide, representing a severe challenge for future healthcare systems. Up to 11,9 million people in Europe are referred to be resistant hypertensive, meaning that they cannot be cured by standard treatments. PA is a certain form of resistant hypertension that can be easily cured by appropriate second-line drug treatments or surgical procedures, if detected. Recommendations by clinical societies suggest extensive screening efforts to facilitate an early detection of PA among resistant hypertensive patients. However, actual clinical practice in Europe does not follow these guidelines due to the lack of appropriate and cost effective screening procedures. If PA remains undiagnosed, it caused severe hypertension frequently resulting in cardiovascular complications including heart attacks and strokes.
The AA2-Ratio is a diagnostic biomarker for PA, that is superior to state-of-the-art assays and allows for a highly specific and cost effective diagnosis of PA among hypertensive patients.";71429;50000;H2020-SMEINST-1-2014;SME-1;ATTOQUANT DIAGNOSTICS GMBH;AT;;; 196394;666482;Sentab;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;SENTAB: Combatting Senior Loneliness through Fun and Entertaining Technology;1/04/2015;30/06/2017;;"A recent study by the researchers of USCF concluded that 43% of seniors over 60 years old feel lonely. The same study concluded that isolated elders had 59% higher risk of physical and mental decline, and 45% see greater risk of death. There are 162 million senior citizens in Europe, and the problem of loneliness affects nearly 65 million Europeans. These people and their families are the target group for Sentab products with the estimated sales potential in Europe alone in excess of 500M per year.

Sentab system is a platform providing entertainment, social interaction, and monitoring functions connecting seniors, their caregivers and relatives seamlessly over the interfaces that are the most common for them TV interface for seniors, and web and mobile interface for caregivers. Early trials at 5 nursing homes in the Greater London Area, UK, indicate that Sentab features have a good alignment with seniors and caregivers needs, but equally, it is necessary to augment the system with further data analysis capabilities to determine emotional state, and short and long term memory conditions of seniors. The project will also establish a solid go-to-market activities mix that will encompass B2B engagements with Nursing and Assisted Living Homes (TAM globally 2Bn), followed subsequently by penetrating B2C Independent Living marketplace (TAM 100Bn).

Ability to analyse user behaviour data on a cost efficient platform and soliciting early actions to respond on negative changes makes this system unique and powerful in changing the habits of elderly care. With this project, Sentab will develop set of complex software algorithms for detecting mood patterns and recognizing trends in seniors emotional state, an internet protocol based communications system and a data base management system. This innovative product will be then placed on EU Assisted Living market.";2340000;1638000;H2020-SMEINST-2-2014;SME-2;SENTAB ESTONIA OU;EE;;; 196486;672974;Delirium Monitor;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Objective delirium detection with an innovative EEG-based spot monitor;1/05/2015;31/10/2015;;"Delirium an acute decline in cognitive functioning is common, serious, frightening, costly and sometimes fatal. Delirium is a great burden for patients because of horrifying hallucinations and impaired outcome and increased risk on dementia. Delirium stresses society because of increased healthcare costs. This is due to prolonged length of hospital stay, and increased rate of discharge to a nursing home thereafter. Costs due to delirium total to 134 billion/year in Europe alone, equaling costs associated with diabetes. Delirium particularly affects hospitalized elderly with reported incidences of 50-80% on the Intensive Care Unit (ICU), and 10-40% in surgical patients. Because of our aging society, patients at risk for delirium will double in the next decades.
Despite its frequency and impact, delirium remains underdiagnosed and therefore undertreated. Delirium is not recognized in 50 - 70% of the cases, which impairs outcome. Early and objective detection of delirium is an unmet clinical need.
Mount Medical (MM), an SME specialized in medical devices, will create and commercialize the worlds first biomarker based device to detect delirium. UMC Utrecht (NL) showed that 1 minute recording of brain activity (EEG) with only 3 electrodes and automated processing could very well identify patients with delirium. A license on the patent will be granted to MM.
Yearly, millions of patients are at risk of delirium that need to be monitored 3 times per day. This generates a 1.4 billion market in the EU and the USA, as for every measurement, a disposable electrode patch is necessary.
A 6 months Phase 1 budget enables biomarker validation and development of noise reduction technology to show technical feasibility, and to commit customers into an Early Access program for market feasibility. Phase 2 is for product engineering and CE certification. EU sales start in 2016, and USA sales in 2017. MM grows to 10\ million in revenue and 50 employees in 2021.";71429;50000;H2020-SMEINST-1-2014;SME-1;WILLEMS-TJOE NIJ ANNEMARIE CHRISTINE;NL;;; 196360;665477;FLOVISP;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Flow Visualization Based Pressure;1/06/2015;30/11/2016;;"The ERC-FLOVIST project has focused on advancing Tomographic Particle Image Velocimetry (PIV) towards a versatile technique for the non-intrusive diagnostics of aero-acoustic problems.
One of the milestones has been the use of Tomo-PIV to infer the instantaneous three dimensional pressure field from the velocity measurement. The use of this laser-based technique for the detection of pressure fluctuations both around and on the surface of aerodynamic models offers the advantage that surface pressure transducers do not need to be installed, along with connecting cables for power supply and data transfer.
The technique has demonstrated high scalability and pressure fluctuations were detected from low-speed up to the supersonic flows. This is an important headway from standard technologies (surface pressure transducers and microphone arrays) favouring a broader utilization of PIV in aero-acoustics, flow-induced vibrations and bio-fluid mechanics.
The potential of this innovative approach has been recognized in science. However, the industry lags behind with a more conservative position, partly justified by system complexity and the high skills required to perform experiments. Instead, when correctly implemented this method can lead to important economical benefits with saving of costs for the integration of instrumentation. The targeted industrial areas are: aeronautics (aircraft aerodynamics and propulsion), energy systems (turbo machinery and wind energy). In wind-energy, the study of unsteady loads may lead to designs that reduce fatigue loads and increase system durability. Also, growing interest in noise emissions from wind turbines requires increased capabilities for their aero-acoustic analysis.
The proposal intends to move forward these capabilities from research labs to industrial facilities. The main task is bringing together the current advances of the Tomo-PIV technique to make it broadly usable by research centres and for industrial innovation.";148750;148750;ERC-2014-PoC;ERC-POC;TECHNISCHE UNIVERSITEIT DELFT;NL;LAVISION GMBH;DE; 196401;666588;SMART-GRAN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014;H2020;Development and Commercialisation of a Self-Guided Fluidised Bed Granulation Solution;1/09/2015;31/08/2017;;The proposed Innovation Project aims to develop and commercialise the worlds first Self-Guided Fluidised Bed Granulation Solution targeted at the pharmaceutical, food, nutritional and cosmetics industries. The SMART-GRAN solution will incorporate a suite of Process Analytical Technology (PAT) analysers for the in-process monitoring and closed loop control of the Critical Process Parameters (physical, chemical and moisture properties of the granulate) coupled with soft-sensoring, for obtaining consistent product quality and safety. The ability of the system to confirm cleaning process success between batches will reduce equipment downtime, increase product throughput and lead to increased productivity. Through a cloud-based data management platform, the SMART-GRAN solution will enable historical data to be available for Quality-by-Design process optimisation for gaining resource efficiencies for improved competitiveness. This will enable intelligence-based manufacturing (IbM) concepts which focus on harnessing the complementary power of data, modelling, engineering and IT infrastructure by transforming data into knowledge and ultimately intelligence, to equip industry to move to proactive manufacturing strategies that deliver predictable manufacturing performance. The commercialization of the system will help IPL to secure a position as a global PAT-based solutions provider to the pharmaceutical sector, generating > 34 M in additional turnover for the company by 2022, and leading directly to the creation of ~58 new high-end jobs through the supply of the system. Roll out to other sectors will treble this potential. Moreover, the competitive impacts upstream and downstream will lead to the creation of up to ~1000 new jobs in Europe.;2462875;1724012,5;H2020-SMEINST-2-2014;SME-2;INNOPHARMA LABS LIMITED;IE;;; 196376;666092;REACTION;SIGNED;H2020-EU.3.1.;Health;H2020;Evaluation of the efficacy and of the antiviral activity of T-705 (favipiravir) duringEbola virus infection in non-human primates humans;1/11/2014;31/10/2017;;The ongoing Ebola outbreak in West Africa is the largest and deadliest the world has ever seen. In September 2014, the number of EBOV cases exceeded the total of all cases from previous known outbreaks. Further, this public health crisis shifted into a complex emergency, with significant, social, economic, humanitarian, political and security dimensions. Till date, no effective medicine has been proven to be effective against EBOV. As a result, it is immensely difficult to mitigate the current outbreak as well as prevent further outbreaks in this region. On Sept 4-5 2014, the WHO gathered expertise on experimental therapies and vaccines and their role in containing the Ebola outbreak in West Africa. During this consultation, experts identified several therapeutic and vaccine interventions that should be the focus of priority evaluation. Among these candidates is the existing antiviral drug Favipiravir, that has proven activity against many RNA viruses in vivo and in vitro including Ebola. Favipiravir is known to inhibit viral gene replication within infected cells to prevent propagation among which it inhibits viral gene replication within infected cells to prevent propagation. Hence, Favipiravir is currently aimed as a curative option in severe pandemic flue. Furthermore, there is currently enough stock of Favipiravir to even treat more than 20.000 patients, and the producer of Favipiravir, Toyoma Chemical/Fujifilm in Japan is willing to rapidly upscale the production of this drug. This drug has been extensively tested in humans and approved in Japan for treatment and prevention of influenza. The drug has shown an excellent safety profile in more than 2000 patients tested and no major adverse effect were reported. The current crisis requires both an immediate response to treat patients and prevent the further spread of the epidemic, as well as long term commitment in the complex sociocultural context. REACTION! will address both needs.;2755719,89;2575809,5;H2020-Adhoc-2014-20;RIA;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;"RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG;FONDATION POUR L INSTITUT DE HAUTES ETUDES INTERNATIONALES ET DU DEVELOPPEMENT;Department of Health;ECOLE NORMALE SUPERIEURE DE LYON;UNIVERSITEIT UTRECHT;UNIVERSITE CHEIKH ANTA DIOP DE DAKAR;DRUG DISCOVERY FACTORY BV;ASSOCIATION POUR LE DEVELOPPEMENT DE L'ENSEIGNEMENT ET DES RECHERCHES AUPRES DES UNIVERSITES, DES CENTRES DE RECHERCHE ET DES ENTREPRISES D'AQUITAINE;BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN;UNIVERSITE D'AIX MARSEILLE;INSTITUT PASTEUR;UNIVERSITEIT VAN AMSTERDAM";"DE;CH;UK;FR;NL;SN"; 196470;672729;Omniflow;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Next-generation hybrid wind and solar power technology;1/05/2015;31/07/2015;;"Wind power is a source of effectively infinite local energy. However, conventional horizontal axis wind turbines are controversial in many communities they are noisy, visually distracting and they vibrate. An obvious disadvantage of wind (eolic) technology is that power generation diminishes when there is no wind. State-of-the-art eolic technologies do not work well in urban environments, which experience vertical and turbulent wind conditions. Solar PV systems main disadvantage is that energy generation peaks during the day while consumption peaks at night, increasing the need for expensive electricity storage (batteries).
The core innovation of Omniflow is our patented omnidirectional wind turbine. By integrating Omniflow with both new and existing photovoltaic (PV) solar energy systems we can offset non-linear solar PV electricity generation and weak eolic microgeneration throughout the day and throughout the year in different meteorological conditions (currently up to 8.8 kW, with PV). Thanks to its design, Omniflow works well in urban environments. There is no visible motion, and it is fully operational both on and off the electrical grid. The applications and target markets range from distributed energy to novel, autonomous telecommunication base stations and intelligent lighting, in urban, rural and crisis-management environments in the EU/worldwide, and has a TRL 6-7, depending on the application.
If we confirm that Omniflow represents a significant business opportunity through the feasibility study in SMEI phase 1, we will proceed to apply for funding in phase 2: objectives include improving our turbine designs to optimize wind to electricity conversion; adapting our technology to a range of meteorological conditions in different regions; and navigating the regulations and certifications necessary for implementation within the international energy and telecom sectors (TRL 8). We project a net profit of 5,792,117 by 2017, as detailed in this proposal.";71429;50000;H2020-SMEINST-1-2014;SME-1;OMNIFLOW SA;PT;;; 196449;672479;MentorPitch;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;The commercial exploitation of mentorship programme outcome intelligence in the global corporate and university market.;1/05/2015;30/09/2015;;"The MentorPitch platform www.mentorpitch.com is highly disruptive in a global mentoring context. It is the first platform to automate the management and measurement of large scale mentoring programmes. MentorPitch measures the outcomes of mentoring programmes in a corporate and education environment. MentorPitch is a Software as a Service (SAAS) cloud-based business. The platform automates the management and measurement of mentorship programmes, thereby reducing the administration time of managing a programme. It is impossible for humans to manually manage and measure the outcomes of large scale mentorships that occur in a mentoring programme. Corporate and university mentoring programme managers face one common problem how to manually manage a mentoring programme and capture the outcomes of all the mentorships in a specific programme.

Our objectives for this project are:
1) To commercially validate the outcome intelligence for university student-alumni mentoring programmes and workplace (multinational/corporate) mentoring programmes. We will do so by engaging closely with our current customers (Dublin City University, Transterra Media) and pipeline customers (University of Warwick, INSEAD, HEC Paris, Harvard Business School and corporate mentoring customers) to develop and capture outcomes using our in-house developed technology for large scale mentorship programmes.
2) The mentor-mentee matching algorithm (based on common skills areas, skills to develop, work experience, education, location and availability), will be developed further and tested to take into account the outcomes of previous mentorships.
3) Prepare a complete Phase 2 business and commercialisation plan, suitable for an SME-Instrument Phase 2 application, including a localisation plan. In phase 2 we plan to localise the content and mobile applications for all key European and international markets, including France, Germany, Italy, Spain, Netherlands, US, Japan and China.";71429;50000;H2020-SMEINST-1-2014;SME-1;THE KEY RESOURCE COMMUNICATIONS LIMITED;IE;;; 196377;666094;Ebola_Tx;SIGNED;H2020-EU.3.1.;Health;H2020;Emergency evaluation of convalescent blood and plasma for Ebola Viral Disease (EVD) in affected West African countries.;1/11/2014;31/10/2016;;"The objective of this proposal is to urgently determine the efficacy, safety and feasibility of convalescent whole blood (CWB) and convalescent plasma (CP) therapy, as a treatment for patients with Ebola Viral Disease (EVD) to reduce the case fatality rate in the present EVD epidemic in West Africa.

The trial will take place in three consecutive phases; i) initial phase to initiate harmonized standard supportive care (SC), ii) evaluation of CWB iii) evaluation of CP. Supportive care (SC) including intravenous hydration and shock management will be standardised and made available to all patients.
Day 14 mortality will be used to determine primary outcome. Survival for patients treated with CWB \ SC or CP \ SC will be compared to SC alone using a non-randomised open-label design. Based on available figures, a 20% decrease in the case fatality rate will be considered proof of clinical efficacy. Internationally agreed stands of ethics and human rights will be applied for the duration of the trial. Written consent will be requested from patients and/or guardians of patients. Every consideration will be given to the safely of health-care workers involved in the trial, including their consent to be involved and adequate training and psycho-emotional support. Given the study context, community communication will be prioritized. We propose a unique partnership of academics, clinical trial units, non-governmental organizations, international research networks, international and local actors to conduct a clinical trial according to the highest standards attainable in the current context. If found to be effective, this intervention can be scaled-up relatively rapidly as the trial will provide the information required to mobilize local partners, with major public health implications.";3035428,34;2892171;H2020-Adhoc-2014-20;RIA;PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE;BE;"London School of Hygiene and Tropical Medicine;ETABLISSEMENT FRANCAIS DU SANG;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;THE UNIVERSITY OF LIVERPOOL;UNIVERSITE D'AIX MARSEILLE;INSTITUT PASTEUR";"UK;FR"; 196434;672197;TurboFeasibility;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Feasibility assessment of direct drive high speed turbo compressors for production oil free compressed air for medium size applications;1/04/2015;30/09/2015;;"Compressed air industry is undergoing a radical change where the share of environmentally friendly oil free air is rapidly increasing and energy efficient turbo compressors are replacing traditional screw compressors. Tamturbo Oy is a high tech start-up company bringing the turbo compressor technology to medium size oil free compressed air applications of 50 to 250 kW as the only European manufacturer which is speeding up the revolution of the 10 B compressed air industry.
In the award winning Tamturbo direct drive design the turbo wheels of a two stage compressor are directly coupled to a high speed electric motor. The main benefits of the turbo design over state-of-the-art dry screw compressors are 15 % lower electricity consumption over the 10-15 year life cycle, decreased operating, maintenance, waste management and overhaul costs due to minimum wear, and the benefit over other turbo designs is better capacity control under variable loads.
Fast business growth is attempted by offering the compressors and related service packages under Tamturbo brand in Scandinavia and under Private Label or OEM contracts in other markets. Medium size compressor manufacturers which do not have access to oil free technology today are seen as the most promising commercialization partners. However, extensive field testing of prototype compressors is needed before full commercialization of the technology.
The objectives of the feasibility study is to acquire direct feedback from end users and potential Private Label and OEM partners as well as to identify European industrial field testing sites for prototype compressors. The Tamturbo business plan including marketing and IPR strategies will be refined accordingly. The actual field testing could be performed in a H2020 Phase 2 SME project.";71429;50000;H2020-SMEINST-1-2014;SME-1;TAMTURBO OY;FI;;; 196432;672123;HYscreen;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;A fast, cost-effective breath analysis technology for Helicobacter pYlori screening at both large and small scale.;1/05/2015;31/10/2015;;"The increasing incidence of Helicobacter (H.) pylori infections and their close link with gastric cancer, gastric lymphoma, duodenal and gastric ulceration, give impetus to the H. pylori diagnostics market.
Existing solutions are too costly, inconvenient and invasive; have a long analysis time or need technical expertise to analyse. Bedfont Scientific Ltd offers a portable H. pylori diagnostic device, HYscreen, which detects ammonia in exhaled air as a biomarker for H. pylori. It has a rapid diagnosis, higher accuracy, lower cost, greater simplicity and convenience. It has the following innovation features: a mouthpiece breath entrapment sampling system, a thermal oxidizer and a Nitrogen Oxide (NO) sensor. This solution is aimed at primary and secondary care in Europe and USA and population screening programs in Asia, answering the call for a cheaper, quicker and simpler monitoring device. This will lead to improved clinical decisions that will facilitate early treatment of the infection, preventing H pylori related cases of gastric cancer and gastric or duodenal ulcers. Consequently, Europe-wide and global savings of up to 1.5 billion and 5.66 billion respectively will be realized by avoiding unnecessary endoscopies, biopsies, expensive H. pylori tests and the healthcare bill from H. pylori-related conditions. Ultimately, HYscreen will open doors for fast and affordable population wide screening. The test will use cheaper C12 urea, though work still needs to be done to make it commercially available.
There is a challenge to shorten the thermal oxidizer system for better aesthetics and to reduce ammonia absorption. In Phase 1, we study the feasibility of optimizing the thermal oxidizer system, the use and optimization of C12 urea, protection of the product and the detailed business plan. Phase 2 will produce the final product from the prototype along with the validation steps and clinical trials.";71429;50000;H2020-SMEINST-1-2014;SME-1;Bedfont Scientific Limited;UK;;; 196487;673048;WeSmartPark;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Giving Drivers Access to Conventional and Electric Car Parking Lots Through the WeSmartPark Enhanced Management System;1/03/2015;31/05/2015;;"WeSmartPark represents a novel technology suite that allows utilizing existing underused parking lots in densely populated cities that will feature electronic charging stations. At no cost to the parking lot owner, equipment is installed that tracks availability and occupancy in real time. The drivers can view, reserve and find parking spots via web browser or mobile app. WSP is the first of its kind in terms of parking management and using under-used private parking lots.
Drivers spend around 20-30% of their driving time in densely populated cities on finding parking lots. At the same time, existing parking lots are only used 60% of the time. On average, WSP offers parking that is at least 50% lower than the average cost in any given city. In Barcelona, WSP charges 1.44 euros per hour, which is less than half of the average price.
The overall objective for the Phase II project is to have launched our validated business model of Barcelona and Madrid to other Spanish and European cities. Some with electric car charging capabilities depending on the outcome of Phase I. This will require specific upgrades of our existing product and the integration of electric car charging capabilities.
Our specific objectives for Phase I are a technological feasibility study of electric car charging lots, an assessment of technological redesign needs, market assessment, business model assessment, risk assessment, IP assessment, work plan for Phase 2 and a Business Plan.
Our product will help meet a series of European transport (better urban mobility, less vehicle congestion) and environmental challenges (reduction of CO2 emissions). In addition, we will help achieve the European Commissions goal to create a tight network of electric car charging stations. The project will enhance our profitability significantly.";71429;50000;H2020-SMEINST-1-2014;SME-1;NOUS PARQUINGS URBANS SL;ES;;; 196429;672058;Assist;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Telocate ASSIST Development and marketing of an acoustic solution for localization and navigation of people in buildings using the smartphone;1/05/2015;31/01/2016;;The central objective of the planned project of the start-up company Telocate is development and marketing of an acoustic location system for smartphone inside buildings, the Telocate ASSIST system, that has higher accuracy and reliability than the existing technical solutions. With its high precision Assist allows for new applications. It enables smartphone users to find their way in large building complexes and to find certain targets in the museum, the trade fair, or the supermarket, and it allows to visually impaired people to navigate through public and administration buildings accurately and reliably.;71429;50000;H2020-SMEINST-1-2014;SME-1;TELOCATE GMBH;DE;;; 196415;671295;INNOVOUCHER;SIGNED;H2020-EU.2.3.2.2.;INNOSUP-4-2014;H2020;INNOVOUCHER: IMPLEMENTING A EUROPEAN LABEL FOR INNOVATION VOUCHERS;1/05/2015;30/04/2018;;"The main objective of INNOVOUCHER project is to develop a European Label for Innovation Voucher programmes, by defining a new model of innovation voucher programme supporting the transnational exchange of innovation services and the procedures of the award of the European Label to those programmes complying with the defined model.
The project will foster the transnational collaboration based in innovation vouchers by increasing the range of services offered in the vouchers scheme to include innovation transnational services and the definition of a procedure of automatic recognition of foreign providers, thus increasing the access of SMEs to knowledge and technology from all across Europe.
The project will define all the aspects of the model (vision, services catalogue, service providers, communication plan, voucher mechanism and the elements for the efficient management of the model), their minimum requirements to enable the European Label award and the European Label system, based on the experience of the consortium partners on the innovation vouchers management. The new model will be tested in real environment in a pilot project by the launch of an innovation vouchers call in five regions to support only transnational exchange of innovation services.
Lessons learnt during the pilot project, jointly with the feedback from other regions from outside of the project will contribute to improve the defined model. The outcome of the project will consist on a guideline of recommendations on the European Label implementation that will provide the European Commission the tools, procedures and model of entity to manage a future European Label system. The guideline will be delivered in two phases: a first draft after the first year of the project and a reviewed version after the completion of the pilot project, at the third year. This guideline pretends to contribute the future policies to be developed by the European Commission on innovation support field.";1513343,75;1513343,75;H2020-INNOSUP-2014-6;CSA;INSTITUTO DE FOMENTO DE LA REGION DE MURCIA;ES;"POLSKA AGENCJA ROZWOJU PRZEDSIEBIORCZOSCI;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;SVIM - SVILUPPO MARCHE SPA SOCIETA UNIPERSONALE;VLAAMS GEWEST";"PL;RO;IT;BE"; 196471;672732;IRIS-1;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;IRIS Feasibility Study Phase 1;1/05/2015;31/10/2015;;"The IRIS Feasibility Study Phase 1 (IRIS-1) Project aims to assess the overall feasibility of the introduction of the Intensive-care Risk prediction and Identification System (IRIS), an innovative real-time patient monitoring and personalised risk prediction and identification system, into the healthcare sector. Thousands of surgery patients in Europe and worldwide die each year due to complications during the post- operative period and thousands more survive with disabilities, making the economic burden of post-operative complications in surgery patients amount to hundreds of millions of euros annually. It is widely accepted that early recognition of complications can reduce their severity and consequences: continuous patient monitoring systems and risk scoring systems are available but they lack suitability for patients in intensive care, trust calculations at time intervals, analyse solely a fraction of available patient data, cannot detect multi-dimensional trends, rely on arbitrary thresholds to generate alarms and cannot be customised for each patient. Thus, there are increased mortality rates and re-admission rates to hospital, contributing to the overwhelming financial and economic burden of public healthcare.
Addressing serious morbidities, such as heart, renal and respiratory failures, and capable of surpassing human limitations in processing large volumes of patient data, IRIS is a real-time adaptive and dynamic patient monitoring and risk prediction and identification system, sensitive to variable interactions and capable of incorporating patient data to identify trends in individual patients physiological parameters that predict post- operative complications.
Developed by RINICARE, IRIS will assist clinical staff to identify at an early stage serious complications in surgery patients, allowing a prompt medical intervention, thus improving the chance of a successful health outcome and contributing to the sustainability of the healthcare system.";71429;50000;H2020-SMEINST-1-2014;SME-1;RINICARE LIMITED;UK;;; 196362;665634;TONALITy;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;commercialisation TridimensiOnal Nanoporous ALumIna Templates;1/07/2015;31/12/2016;;One of the results obtained under the project nano-TEC (ERC-StG-240497) is an alumina template with three-dimensional nanopore architecture. This novel structure and its fabrication procedure have been the subject of a patent that has been recently filed. This structure has the novelty of being composed not only by vertically aligned pores, but also by tailor-controlled horizontal pores interconnecting them with their closest neighbour creating a three-dimensional net of nanopores. This template can also be used for the fabrication of highly ordered three-dimensional network of nanowires. Controlled and uniform assembly of nanowires with high scalability is still one of the major bottleneck challenges in fields such as energy harvesting, sensing, and device integration for electronics or catalysis. Moreover, since the spacing between horizontal interconnected nanopores is tuneable the colour of the alumina film can be controlled showing rainbow-like luminous colours that change with the angle of view, like in a Morpho butterfly wing. The work already undertaken under the nano-TEC project requires further investment in order to explore larger area, mass-production of these templates, for a further understanding of target markets and their limitations (regarding cost, aluminium purity, sizes, etc.). Finally, the objective will be to place some of the ERC-StG Nano-TEC results at market level.;149953;149953;ERC-2014-PoC;ERC-POC;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 196456;672611;Remote Sanitation;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Remote Sanitation New sustainable sanitation solution for remote areas;1/05/2015;31/10/2015;;"Low quality sanitation is a huge global, growing environmental and health problem with large costs to society. Poor hygiene
and waste treatment results in lower productivity, spreading of diseases and pollution. There is a lack of efficient and green
solutions addressing specific sanitation needs in remote areas such as: refugee and military camps, remote industrial and
household sites.
The awareness of the problem is increasing and authorities have begun to act within this area - e.g. the United Nations
Environment Programme has stated that every dollar invested in safe water and sanitation has a pay back of US$3 to US
$34 depending on the region and the technology deployed.
Aalborg Rrteknik ApS (ART) have invented a new sanitation solution, applicable in remote areas without access to sewage
infrastructure. This turnkey system solution, consisting of 3 main modules (hygiene unit, waste water treatment, sludge
handling), has superior advantages to alternative solutions by being e.g. mobile, reusable, hygienic, environmentally friendly
and affordable. In addition, ART will include services such as camp architecture, installation and maintenance, ensuring
maxmized efficiency of the solution.
Red Cross have been an important contributor in the project and also led the way to market introduction targetting aidworker
base camps. The unique selling points of the new solution are estimated to secure a market share of 15% within 5
years, resulting in an enhanced profitability and significant growth for ART.
In this phase 1 study, ART will perform a demonstration exercice, as well as conduct extended market studies to develop an
appropriate IP strategy, in preparation of a phase 2 project. The outcome of this stage, will be a feasibility report and
business plan. This project and requested financial support, will address an innovative and sustainable solution, with clear
benefits for users, with consequent impacts in the environment and the society as a whole.";71429;50000;H2020-SMEINST-1-2014;SME-1;AALBORG RORTEKNIK APS;DK;;; 196345;665055;NETEEG;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Spatial super-resolution of electrophysiological measurements;1/04/2015;30/09/2016;;"Electroencephalography (EEG) is the non-invasive recording of electrical brain activity, and is an indispensable diagnostic and research tool. A significant advantage of EEG compared to other brain imaging modalities is its high temporal resolution. The downside of EEG is, however, its poor spatial resolution, which is one of the reasons for its gradual replacement by costlier alternatives. It results mainly from the sharp discontinuity in the electric conductivity of the skull bones acting as a strong low-pass filter and limiting the amount meaningful information that can be extracted from EEG signals.

We propose a novel concept of EEG measurement hardware which, in combination with signal processing techniques, will increase the spatial resolution of EEG by as much as an order of magnitude. Our idea is based on the observation that by connecting a dynamic network of controllable impedances between pairs of measurement electrodes, one can alter the shape of the spatial filter constituted by the skull. Since EEG is a relatively narrow-band signal (about 100Hz, limited by the time constants of basics units of neural activity), we expect to be able to measure tens or hundreds of different configurations of the network, either directly or by using a compressed sampling scheme, without compromising the temporal resolution. This will introduce many independent equations to the EEG inverse problem and improve source estimation, having critical impact on the diagnostic capabilities of EEG as well as on its use in emerging applications such as neuro-feedback and brain-computer interface (BCI).";150000;150000;ERC-2014-PoC;ERC-POC;TEL AVIV UNIVERSITY;IL;;; 196400;666570;Interactive Video;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Automatic creation of interactive video to double video advertising revenues whilst decreasing inconvenience for viewers;1/04/2015;30/11/2016;;"Adways is a fast-growing, cutting-edge startup company specializing in interactive video. The project involves commercializing interactive video technology for specific adaptation to the advertising monetization requirements of major media outlets.
With video advertising formats becoming more considerate of Internet users and more lucrative for media outlets, interactive video is increasing the profitability of videos whilst decreasing the inconvenience for surfers. This smarter advertising format has real disruptive potential on the online video advertising market. Yet production process still needs to be industrialized in order to address media outlets' current monetization problems on a large scale.
At the end of the project, Adways is aiming to be in a position to commercialize an application that enriches videos fully automatically. The solution will automatically add relevant interactive content based on video context analysis. The objective is to provide new added-value information to Internet users whilst the videos play. This interactive content will be monetized as an additional advertising inventory. The enrichments, which will be easily deployable on a very large scale but incorporated into the content of the videos, will be widely accepted by Internet users despite the occasional similarity to advertising.
The objective of this project is to double the advertising inventory and video revenue of media outlets and obtain 50% market share among French media outlets after eighteen months. As a technology provider, Adways earns a fee of 25% of the advertising revenue generated for target sales exceeding 2 million in the first year. The revenue forecast is more than 100 million five years after the project's start, thereby creating a new interactive video advertising technologies market led by Adways in Europe. Therefore, Adways would create 300 direct jobs and hundreds of indirect jobs amongst its clients.";1352175,75;946523;H2020-SMEINST-2-2014;SME-2;ADWAYS;FR;;; 196419;671864;CNAP HD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Continuous Non-invasive diagnosis of Arterial Pressure and Hemodynamics;1/05/2015;30/09/2015;;"CNSystems' CNAP HD technology is an innovative diagnostic tool for a significant reduction of peri- and postoperative complications resulting in an enhanced recovery after surgery. Consequently, the use of CNAP HD reduces length of hospital stay and decreases costs substantially. The planned diagnostic devices CNAP HD integral and CNAP HD connect are designed for the continuous non-invasive or minimal-invasive measurement of hemodynamic (HD) parameters. These parameters are biomarkers, which classify as measurable diagnostic indicators that are used to assess the risk or presence of disease.

CNAP HD integral / connect will be used for diagnosing HD. It will guide intravenous fluid and inotropic therapy by achieving goals for cardiac output (CO) and other dynamic biomarkers in order to optimize the balance between oxygen supply and demand. Keeping the patient's fluid status in balance is the most effective way to combat complications such as infections, global tissue hypoxia, shock and multi organ failure.

Medical outcome of the new diagnostic method is impressive: if HD is optimised by CNAP HD, overall complication rate will be reduced by 34% (from 83% in a group with standard treatment to 55% in HD-optimised patients) and infections will decrease by 61% (from 57% in standard treatment to 22%). CNAP HD has further proven clinical accuracy shown in various validation, application and outcome studies.

The greatest impact regarding cost savings will be achieved in medium to high-risk surgeries and/or in medium to high-risk patients. Elderly patients with existing co-morbidities will benefit most. The annual cost savings potential for Europe with its age structure is ? 2.6 billion.

For its broad rollout, the technology has to fulfil usability needs of anaesthesiologists working in OR's. For that a vast innovation thrust is planned. The current proposal describes how CNSystems wants to successfully design its new diagnostic devices CNAP HD integral / connect.";71429;50000;H2020-SMEINST-1-2014;SME-1;CNSYSTEMS MEDIZINTECHNIK AG;AT;;; 196303;664050;COOL POWER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Efficient microgeneration combined with food cooling systems in trade, crafts and service companies;1/03/2015;31/07/2015;;"The project intends to commercialise an efficient microgeneration technology combined with food cooling systems in trade, crafts and service companies.
The innovative core of microgeneration is an ORC cycle operating with a significantly lower inlet temperature of less than 60C that allows for utilising heat from cooling systems that have not yet been used due to the absence of an applicable technology. The system offers higher electrical efficiency and higher flexibility to different inlet temperatures than comparable systems. This opens a tremendous range of new applications opportunities of distributed, sustainable electricity generation based on recovering waste heat. The ?ORC system offers the unique opportunity to implement microgeneration in target markets with cold food storage, incl. food processing, food and beverage retail and service providers, and accommodation, which are producing considerable amounts of waste heat and which are potentially counting for ~10 % of the energy consumption in Europe. The commercial potential corresponds to 2.5 million installations in Europe at the moment.
The feasibility assessment shall prepare the commercialisation of the super-low temperature ORC based ?CHP system and elaborate a detailed business plan. In particular it defines a roadmap for further product development and identifies market areas and the specific target groups. The study investigates the details of customer needs and expected market structures, proves the technical and economic viability of the technology and prepares technical requirements, product documentation and data sheets.
The developed technology directly contributes to European societal challenges such as reducing the consumption of fossil resources and the emission of greenhouse gases and it facilitates low-cost and low-carbon decentralised energy generation. Moreover it contributes to the implementation of the Microgeneration Resolution of the European Parliament (2012/2930 RSP).";71429;50000;H2020-SMEINST-1-2014;SME-1;HKL ENERGIEANLAGEN AG;DE;;; 196347;665275;Timtrace;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Tracing tropical timber;1/10/2015;31/03/2017;;"An estimated 50% of the tropical timber that enters the European market is illegally harvested. To implement new European legislation intended to eliminate this illegal trade, independent tools will be needed to verify the legal status of timber. We therefore propose to develop a fast, accurate and cost-effective commercial forensic tool, 'Timtrace', for tracing the claimed origin of tropical timber. Timtrace uses (1) ring-width measurements that can be matched with reference measurements or climate data, (2) stable isotopes in the wood that can be matched with regional reference data, and (3) DNA analyses that allow distinguishing timber obtained from different areas. The application of multiple methods greatly expands the number of tropical timbers whose origin can be traced.

Our forensic approach is competitive, as unlike current commercial alternatives, it does not require access to the timber in the country of harvest. Potential customers of Timtrace include the customs and inspection authorities, the timber-processing industry and organisations that certify sustainable forest management. Several of these stakeholders have already shown interest in a commercially available and cost-effective forensic tool for timber tracing.

Timtrace builds on the results and expertise obtained during the ERC-funded TROFOCLIM project in which we assembled databases with many thousands measurements of tree-rings and stable isotopes for 20 tropical timber varieties from three continents. Results of the TROFOCLIM project will be directly applied for tracing tropical timbers and will also serve as reference data.

We will use the ERC Proof of Concept Grant to (1) develop a fast, accurate and cost-effective tool for forensic tracing of tropical timber and (2) evaluate its commercial feasibility. By the end of the PoC project we aim to have a Minimum Viable Product which will satisfy the demands of the first customers.";148387;148387;ERC-2014-PoC;ERC-POC;WAGENINGEN UNIVERSITY;NL;;; 196385;666287;PAYPLUG LABS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Next generation online payments and fraud detection API for European SMEs;1/06/2015;31/12/2017;;"The European e-commerce market is growing fast, but the complexity of setting up online payments and the concerns about credit card fraud still represent significant barriers that prevent many SMEs from trading online. Indeed, the EUs target for 33% of SMEs to be selling online by 2015 is far from being met (only 14% in 2013).

PayPlug Labs aims to offer SMEs a next generation payment system that will reduce software integration costs thanks to a state-of-the-art REST API, and provide low-touch fraud protection thanks to modern statistical algorithms and machine learning.

The project fills the gap between traditional online payment solutions, that require expensive integration efforts, and e-wallet solutions. Additionally, existing fraud detection systems are commercialised separately and rely on dated rule-based technologies implying prohibitive set up costs for SMEs.

The project will be led by PayPlug, a company created in 2012 that has developed an easy-to-install online payment plugin for micro-enterprises. The company is composed of a talented management team with a strong background (Google, Harvard, Polytechnique), and a high-profile advisory board. The company has attracted 1.4M of private investment and employs 10 full-time employees.";2977725;1750000;H2020-SMEINST-2-2014;SME-2;PAYPLUG;FR;;; 196441;672389;FREEWAY;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;FREEWAY : safely and effortless commute in an urban environment;1/06/2015;30/11/2017;;"It is not a bike, it is not a scooter, it is a lot better, its FREEWAY: a new revolutionary means of transportation allowing to safely and effortlessly commute in an urban environment.
Protected by a worldwide patent, FREEWAY is a small and clean scooter, on three wheels. FREEWAY is unique since it is very light, 14kg, with 2 front wheels for stability and safety, a back wheel that includes the electric engine, and it is fitted with latest generation batteries. FREEWAY may be folded and unfolded within seconds. When folded, it can be carried along, on its two front wheels like a suitcase. Therefore, FREEWAY may be kept with you at all times and is perfectly suitable for intermodal mobility.
FREEWAY is an hybrid type of bike with no equivalent product on the market; nevertheless, its market is already very broad. The most direct competition of FREEWAY comes from electric bikes, with a good market growth rate that should be 9.1% over the 2013-2020 period, to reach a market of 1,9 million in Europe.
The main objective of FREEWAY business innovation project is the transfer of a new innovative and competitive solution seizing European transport sector opportunities with the view of providing profitability and growth.
The specific objectives will be to provide technological and economic viability of FREEWAY electro mobility concept in order to develop a market strategy ensuring Europe wide market uptake, support growth and self-sufficiency at mid-term and participate to Europe bike industry leadership.
In addition, FREEWAY business innovation project will address urban environmental and mobility defies by offering the market with an innovative electric powered vehicle which is more light, more practicable, more safe and secure and more trendy for the users, thus, improving users quality of life with an innovation offering a door-to-door environmentally-efficient mobility that will quickly and successfully break into European market.";2364343,75;1655040,63;H2020-SMEINST-2-2014;SME-2;FREEWAY SAS;FR;;; 196417;671839;SUMOblock;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Blocking SUMO conjugation as drug discovery strategy.;1/06/2015;30/11/2016;;"In eukaryotes, SUMO (Small Ubiquitin Modifier) conjugation to proteins is an essential process that regulates many aspects of cell biology. Defects in SUMO conjugation have been associated to cancer, neurodegenerative diseases and others, raising a great interest in developing novel drugs for inhibiting SUMO conjugation.

Specifically, recent reports have pointed to a high dependency on an active SUMO conjugation by Myc-overexpressing cancers. Consequently, SUMO conjugation has become a non-oncogene addiction target of special relevance since the oncogenic Myc is nondruggable. Based on the results obtained by our group, we have developed a novel assay for identifying efficient SUMO conjugation inhibitors, which could lead to the identification of novel therapeutic drugs.

The main outcome that we expect to obtain from this project is the identification of a SUMOylation inhibitor that will be patent protected. Initial steps towards the valorization of the identified product will be taken, and available commercialization opportunities will be carefully analyzed for entering into the next steps of drug development, including preclinical and clinical studies.

The fact that SUMOylation may be a key element in almost 70% of cancer types due to its involvement in the Myc pathway makes the search for hit drug candidates an enterprise worth taking, which could benefit millions of people worldwide.";150000;150000;ERC-2014-PoC;ERC-POC;CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB;ES;;; 196288;663865;SUNIGENT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Intelligent sunlight system for energy efficient indoor lighting;1/03/2015;30/06/2015;;This project will develop, demonstrate and bring to market an innovative intelligent sunlight system for energy efficient indoor lighting. The project will bring together architects, construction companies, light designers and other daylight-, lighting-, energy- and sustainability stakeholders to fully utilize the potential in flexible daylight. The first phase will investigate the feasibility of the innovation project and plan for phase 2 and 3. Phase 2 comprises demo activities with potential users. The project will bring the innovation from TRL 6 to TRL 9. Phase 3 include market launch on European and global markets.;71429;50000;H2020-SMEINST-1-2014;SME-1;PARANS SOLAR LIGHTNING AB;SE;;; 196448;672474;WEL-FIT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Feasibility Study of the induction WELding, FIbre placement and shaping of Thermoplastic composites;1/06/2015;30/11/2015;;"BERCELLA, Italian SME with established expertise in composites for advanced applications, has identified in the induction heating a breakthrough enabling technology to welding, shaping and fibre placement of composites coupled with Non Destructive Inspection. Innovative ranges of thermoplastic reinforced carbon fibre composites will be the subject of the project, unlocking new products, and revolutionising the sector. The process is established through cooperation with the research centre CETMA, granting to BERCELLA the access to the relevant know-how in the field of induction welding, developed through years of research and laboratory practice, and protected by patents.
The objectives: Technological Feasibility, Market Assessment, Business Models and Plans, are addressed through a structured approach. Barriers to the implementation will be identified and overcome, permitting to identify a complete roadmap towards the industrial shop-floor and the market approach. Innovative range of products can be manufactured thanks to the innovative process, control and adaptation of the induction equipment to a range of materials that can be extended via a continuous process of industrialization, stimulated by the quality and competitiveness of the results.
The basis for a successful Phase 2 project are set in accordance to the results of the present Feasibility Study, for the industrial and market acceptance of induction as a one-stop process for sustainable, automated composites manufacturing.";71429;50000;H2020-SMEINST-1-2014;SME-1;BERCELLA SRL;IT;;; 196414;669046;SCALEPHA;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Industrial and commercial SCALE-up of Bio-on technology for the production of PHA polymers from sugar industries waste, co- and by-products;1/05/2015;31/10/2015;;"The objective of the SCALEPHA Project is to contribute to the protection and sustainable management of natural resources and ecosystems through a sustainable supply and use of raw materials in the industrial production of 100% biodegradable bio-plastic, in order to meet the needs of a growing global population within the sustainable limits of the planet's natural resources and eco-systems.
SCALEPHA activities will contribute to increasing European competitiveness, raw materials security and improving well-being, whilst assuring environmental integrity, resilience through an innovative integrated technology: Polyhydroxyalkanoate (PHAs).
European Factories of the Future will have to be SMART (high performance, reconfigurable, adaptive and evolving factories based on new technologies) and GREEN (reduced ecological footprint through a more efficient use, at factory level, of material and energy resources): SCALEPHA project will demonstrate that Biotechnologies, such PHAs production, are the strategic technologies needed to keep the European Manufacturing leading edge.
Side Objectives:
- penetrate significantly the existing bioplastic market through PHAs (in particular Biomedical, Food Packaging and Design sectors);
- diffusion and uptake of PHA innovation on a broad scale, maximising its economic and environmental benefits;
- create or enlarge new markets for related PHAs products providing opportunities for growth and jobs at Local, National and European levels.
- deploy a key environmental product obtained with smarter and greener processes addressing the challenge of resource scarcity, water and soil pollution.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIO-ON SPA;IT;;; 196402;666624;IRWES;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;Integrated Roof Wind Energy System;1/04/2015;31/03/2017;;"The Integrated Roof Wind Energy System (IRWES) is the breakthrough solution overcoming all shortcomings of existing renewable energy solutions. IRWES is a roof-mounted, elegant structure with an internal nonvisible turbine making smart use of aerodynamics. It is more efficient than any existing urban windmill, and more efficient per area than PV panels when mounted on roofs higher than 20m. This novel system has highest efficiency based on IP protected and tested technology (TRL6). It reduces the payback time by effectively producing electric power in both high and low wind speeds resulting in both more efficiency and operational hours. The Netherlands counts 35.000 buildings suitable for application with attractive ROI, while greatest impact is achieved in Europe where 1/6 of the population lives in high-rise buildings. Customers have already committed to 25 units after demonstration. IRWES is a business opportunity ready for large growth, to serve the until now unreachable segment of local renewable energy supply to high buildings, while seamlessly aligning with the Horizon 2020 Work Programme objectives. Moreover, IRWES addresses European and global challenges such as reducing the risk of carbon lock-in, offering sustainable and affordable alternatives to rising electricity prices as well as closing the gap between R&D, innovation and entrepreneurship. Its market excellence is defined by meeting the important customer demands differentiating in aesthetical integration and customization; creating more value as an outstanding, attractive solution. Our business objectives have been outlined in 8 Work Packages to prepare the IRWES mass-market launch, positioning it as a game changing solution on the European market. Based on rigorous studies and feasibility assessments, already performed, we present a solid business plan that incorporates a commercialization strategy and a financing plan to underpin the foreseen market launch and growth strategy of IRWES.";2423400;1696380;H2020-SMEINST-2-2014;SME-2;IBIS POWER BV;NL;PONTIS ENGINEERING BV;NL; 196404;666644;BioValue;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;Quality determination of solid biofuels in real time;1/03/2015;31/05/2018;;"Mantex proposes to build a novel biomass scanner for the measurement of inhomogeneious biomass that will be based on its 1st generation solution for the pulp and paper industry. The new solution will not only analyse homogeneous biomass, like woodchips, but various types of biomass and from different origins. Mantex will sell to the European bioenergy industry.

Mantex will address one of the key challenges in growing the use of biomass today: the difficulty in obtaining reliable quality measures. The quality of biomass varies greatly as different kinds of biomass and lots have different compositions. However, state-of-the-art measuring technologies are not appropriate for effective decision-making, because they lack accuracy and reliability and have long timing delay for use in the dynamics of boiler control.

Manex will build and test a full scale demonstrator at a trial customer (WP4 and WP5). The demonstrator will be installed at a large-scale bioenergy plant and analyze the biomass on a moving conveyor belt in realtime determining the most important key parameters (i.e. moisture content, calorific value, ash content and unwanted items) to high precision (WP5). Mantex will then attempt to categorise biomass effectively into classes that a bioenergy producer can separate.

With this solution, for the first time, accurate knowledge of biofuel quality will be available in real time. This makes it possible to (1) make significant efficiency gains in boiler operations at bioenergy plants (2) establish categories of various biomass types according to an incineration rather than a species perspective (3) make sourcing and the trade of biomass more efficient.

Mantex receives several inquiries a week from various countries and has presold the new scanner prior to the start of the suggested development. Hence, demand for the scanner can already be demonstrated.";2335550;1634885;H2020-SMEINST-2-2014;SME-2;MANTEX AKTIEBOLAG;SE;;; 196455;672598;SMASH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;SMASH, SMArt SHaring device for mobility;1/05/2015;31/10/2015;;"SMASH is a Smart Sharing Device aiming to improve the access and the fruition of innovative urban mobility, through the combined use of satellite tracking technology and wireless transmission, embedded in a single miniaturized device.
The proposed device, developed by greenspider and available in prototype, integrates in a single ultra-low-power electronic circuit a GNSS receiver, Near Field Communication (NFC),Bluetooth Low Energy (BLE), and GPRS module for connection to the cloud. The supported NFC is compatible with the standard nowadays adopted by major Smartphones manufactures and mobile operators, and it's considered a disruptive technology to enable secure authentication, mobile access and payment via Smartphone. With this characteristic SMASH permits a direct NFC interaction with end-user smartphone, and correlate positioning data retrieved from different positioning device.
SMASH enables access to innovative mobility schemes, thanks to its embedded GNSS and proximity interaction between the user's Applet and the device. The device can be integrated into vehicles and infrastuctures, like parking or charging stations, or in general in any resource in a sharing scheme, allowing easy NFC controls and data sharing. Thanks to the NFC connection,the data related to the user's access request and to the available resources, with the relative positions, are exchanged in a safe and reliabl way, and shared in the cloud, enabling innovative mobility service and advanced fleet management. The units of fleet management in Europe has risen from 1.5 million units in 2009 to 4 million in 2014, and are expected to grow further in the next years. The penetration of NFC across all handset is planned to reach approximately 32% by 2017, with more than 1 Billion smartphone with NFC support. In this market scenario the sales forecast for SMASH device reach several million of units in few year, with a target of 5 Millions euro in 5 years.";71429;50000;H2020-SMEINST-1-2014;SME-1;GREENSPIDER GMBH;DE;;; 196426;671999;NANO-POS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Miniature Controller for NANO-meter level Motor POSitioning;1/05/2015;31/10/2015;;"INGENIA is a company dedicated to the science of motion control since 2006. We design and manufacture electronic solutions to answer the industrys need for increasingly complex, high-tech motion control applications. We are proud to say that our technology has been integrated by leading machine manufacturers around the world in the industries were we put our focus: Examples are SAMSUNG in South Korea (Semiconductors), PROYTECSA in Spain (Defense Robotics), BEI KIMCO in USA (Medical), ENGTEK in Singapore (SubSea Robotics) and THALES in France (Robotics).
Our VISION is to become a reference in the most sophisticated and challenging motion control applications in our market segments. With that aim and in order to be one-step-ahead in developing innovative, feature-rich, high power-density, and ultra-compact products that give our clients a competitive edge, INGENIA is preparing the launch of NANO-POS, a Miniature Motion Controller for NANO-meter level Motor POSitioning.

The NANO-POS project rationale is to offer a new disruptive motion control technology that covers the unsatisfied needs of Medical, Semiconductors and Robotics applications, requiring ultra-high precision positioning systems with superior performances while keeping a miniature size due to space constraints.

NANO-POS is currently between TRL6 and TRL7 levels and should be in TRL9 within an 18 month timeframe. The planned overall project investment is 1.5M and the expected break even for the ROI is in 2017.";71429;50000;H2020-SMEINST-1-2014;SME-1;INGENIA-CAT S.L.;ES;;; 196433;672134;DEALS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Biomarker assay development to expedite ALS experimental therapeutic advancement;1/05/2015;31/10/2015;;"The unique Dutch SME Treeway B.V. was founded in 2012 by two highly experienced and successful entrepreneurs that both have been diagnosed with amyotrophic lateral sclerosis (ALS). It is Treeways mission to eradicate ALS from the face of the earth by speeding up ALS research and bringing new therapies in the market as soon as possible. Treeway already has one new therapy in clinical development, which has recently received EMAs Orphan Medicinal Product Designation.

ALS is a rare disease that is characterised by muscle spasticity and rapidly progressive weakness due to muscle wasting. This results in difficulties in walking, moving, speaking, swallowing, and breathing. Most ALS patients die from respiratory failure within three years. ALS diagnosis currently is mainly aimed at excluding other diseases with similar symptoms. As a result there is a 914-month delay between symptom onset and final diagnosis of ALS. For similar reasons, there is also a lack of accurate and practical diagnostic tests for monitoring the benefit of potential therapeutic interventions for ALS. This is severely slowing down the progression of clinical drug development in this field.

As ALS drug developer, Treeway will greatly benefit from the availability of a (combination of) quick diagnostic assay(s) to be used in monitoring therapeutic efficacy in clinical trials. In addition, the ALS diagnostic tool may also proof to be instrumental for (speeding up) the initial diagnosis of the disease.

Therefore, within DEALS, Treeway will perform a mostly paper study to investigate the technical and economic feasibility of developing a quick and reliable diagnostic tool. These developments will be based on known and detectable biomarkers of the disease. Economic benefit will stem from the ability of the assays to enable earlier diagnosis and to speed up clinical drug development; per one month gained in development time for a new ALS drug, about 25 million additional revenues can be foreseen.";71429;50000;H2020-SMEINST-1-2014;SME-1;TREEWAY B.V.;NL;;; 196315;664331;InnoRenew CoE;SIGNED;H2020-EU.4.a.;WIDESPREAD-1-2014;H2020;Renewable materials and healthy environments research and innovation centre of excellence (InnoRenew CoE);1/06/2015;31/05/2016;;With excellence in research, innovation, and application into economy and society, the new Centre of Excellence, Renewable materials and healthy environments research and innovation centre of excellence (InnoRenew CoE) will improve sustainable building practices by combining the existing concepts with the Restorative Environmental Design (RED) paradigm, which combines sustainable building practices with biophilic design. This will increase the competitive advantages of the affiliated renewable resource-based construction industry, and create innovation and market pull for RED-based materials and products (holistic living environment). Consequently, innovation and market pull for material recovery and higher added value renewable resource based and energy carriers will be initiated. Research and development activities will seek the optimal intersection of performance and sustainability, including economic, environmental and societal indicators. With support and guidance from the advanced partner, Fraunhofer WKI, scientific research and development activities will be transferred profitably and efficiently to the industry and through them to society in the form of innovative new products and processes.;495625;495625;H2020-WIDESPREAD-2014-1;SGA-CSA;UNIVERZA NA PRIMORSKEM UNIVERSITA DEL LITORALE;SI;"ZAVOD E-OBLAK POSLOVNE IN RAZISKOVALNE DEJAVNOSTI;UNIVERZA V MARIBORU;INSTITUT ZA CELULOZO IN PAPIR;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;INNORENEW COE CENTER ODLICNOSTI ZA RAZISKAVE IN INOVACIJE NA PODROCJU OBNOVLJIVIH MATERIALOV IN ZDRAVEGA BIVANJSKEGA OKOLJA;NACIONALNI INSTITUT ZA JAVNO ZDRAVJE;JAVNI ZAVOD REPUBLIKE SLOVENIJE ZA VARSTVO KULTURNE DEDISCINE;REGIONALNA RAZVOJNA AGENCIJA - LJUBLJANSKE URBANE REGIJE ZAVOD;ZAVOD ZA GRADBENISTVO SLOVENIJE";"SI;DE"; 196387;666346;APEX;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014;H2020;Advanced Process Economics through Oxidoreductases;1/04/2015;31/03/2017;;"Within the APEX (Advanced Process Economics through Oxidoreductases) project, MetGen will bring MetZyme from small pilot scale to industrial production and commercial applications. MetZyme is used to liberate cellulose from lignocellulosic material through oxidation of lignin. MetZyme is an enzyme solution developed by MetGen, based on thermostabile oxidoreductase enzymes with wide pH tolerance, designed for harsh industrial conditions. This scale-up allows for its market demonstration at the industrial scale, within two target industries: pulp & paper mills and biorefineries where process economy is improved through energy- and technology cost reduction.
In APEX, MetGen will also further improve the cost-efficiency of the industrial enzyme development technology, protected by international patents. The value proposition and competitiveness of the process are supported by lowering the production costs and optimising the whole supply chain in APEX.
Small scale pilot studies have been already done with large industrial customers. They have shown that MetZyme can significantly improve the economic and environmental sustainability of paper, chemicals, and biofuels industries that are in a great need of more efficient processes with lower costs. Within pulp and paper it can significantly help to lower the production costs, based on reduced energy and chemical usage and improved fibre quality. MetZyme also helps to optimize the catalysis of lignin and sugar conversion. This enables low-cost production of cellulosic fibers and sugars and supports the production of second-generation biofuels and bio-based chemicals, paving the way to sustainable European bioeconomy.
APEX makes it possible for MetGen to bridge the gap between pilot and industrial scale, and thus become profitable and competitive, and in a few years to be recognized as one of the worlds most significant enzyme companies.";2202250;1541575;H2020-SMEINST-2-2014;SME-2;METGEN OY;FI;;; 196473;672761;CORE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Camelina Oil for Sustainable Salmon Aquafeed;1/05/2015;31/10/2015;;"Seafood is a major source in the human diet of Omega 3 long-chain poly unsaturated fatty acids -such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)- , which plays a very important role in human health.
Fish oil is a vital strategic ingredient for farmed fish and crustaceans, since it provides the required quantities of Omega 3 fatty acids, especially at the critical growth stages.
The prospects for increasing the production of fish oil are very limited, since most of the fisheries for fish oil production are now tightly monitored to not exceed the established fishing quotas and Total Allowable Catches (TACs). As current supply rates cannot keep up with demand, the fish farming industry, which grows close to 6% annually, in future will have to use less fish oil.
To remain competitive, limit environmental degradation and optimize the efficient use of fish oil, the development of more resource-efficient and sustainable vegetable oil for aquafeed production is needed.
Camelina oil, due to its unique fatty acid composition, is a sustainable vegetable oil that shows higher potential than other vegetable oils to replace fish oil in farmed salmonids diets while contributing to maintaining DHA and EPA levels.
Camelina Company Espaa (CCE), the European leader in sustainable camelina oil production, will perform a feasibility study to evaluate the new business opportunity of introducing camelina oil as an innovative key ingredient in the new oil blend that salmon aquafeed producers are currently developing to reduce fish oil dependency and increase the technical and environmental performance of salmon fish feed.";71429;50000;H2020-SMEINST-1-2014;SME-1;CAMELINA COMPANY ESPANA S.L.;ES;;; 196386;666312;TRADECOM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;TRADECOM: Trader communication, collaboration and compliance system;1/08/2015;31/01/2018;;"In the proposed project, TRADECOM: Trader communication, collaboration and compliance system, the project partners will develop and validate innovative hardware and software solutions to meet the communication, collaboration and compliance needs of financial services, energy and commodity trading and brokerage markets.

The TRADECOM project partners will design and develop a new desktop communication endpoint (known as a trader turret) that will provide traders and brokers with high-quality, instant, private and secure group communications using intuitive user interfaces. The partners will also develop and implement necessary backend communication and media services to enable scalable, resilient and compliant call routing and recording via the internet and cloud services. The project will introduce new middleware that will link trader turrets to corporate computer systems, enabling turret functions to be accessed from enterprise applications (e.g. click-to-dial) and application data to be accessed from the turret (e.g. contacts and call groups). This will provide traders with more efficient ways to manage communications and workflow between the turret and other desktop systems. The TRADECOM turret will be designed to interoperate with Speakerbus emerging virtual turret (vTurret) services, which will replicate the TRADECOM trader communication services on desk and mobile devices. This will enable traders to work away from their main TRADECOM turret and still access specialist voice and data communication services. An important focus of the project will be to pilot and demonstrate the integrated TRADECOM systems in real operational environments and to assess the impact for traders and trading organisations. Taken together, these innovations will disrupt the trader voice market and its large incumbent technology suppliers, and provide high growth opportunities for the SME project partners.";2452933,75;1717053,63;H2020-SMEINST-2-2014;SME-2;SPEAKERBUS TECHNOLOGY LIMITED;UK;"INDUSTRIALPARTNERS GMBH;HISBIM HISARLAR BILGI VE INOVASYONMERKEZI SANAYI VE TICARET ANONIMSIRKETI";"DE;TR"; 196440;672308;ERCSC-VPRES-SUP2015;SIGNED;H2020-EU.1.1.;ERC;H2020;Support to the Vice-Presidents of the ErC Scientific Council 2015;1/01/2015;31/12/2015;;The proposed Action will provide the necessary support to the Vice-Presidents of the European Research Council Scientific Council (ERC ScC) to achieve key milestones and deliverables of the ScC, which are required under the Horizon 2020 framework programme.;276125;276125;H2020-Adhoc-2014-20;CSA;Universitat Pompeu Fabra;ES;;; 196389;666423;Adaptcontrol;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;A modular and compact controller design for light electric vehicles;1/04/2015;31/03/2019;;"Electro-mobility is one of the keys to achieve European objectives to reduce emissions and to halve the number of conventionally-fuelled vehicles by 2030.
Having identified the huge opportunities within the Electric Vehicles market, our company Bultaco Motors has revealed two all-electric motorcycle prototypes in May 2014 that will point the way forward in the electric motorcycle market. Supported by our excellent team, we have developed the whole power-train in-house. In the project Adaptcontrol, Bultaco Motors will go a step further and re-engineer an industrial solution of the currently used controller within the power-train with a solid performance at a competitive cost as well as validate the controller in fully operational environment and working conditions. Adaptcontrol aims at developing an enhanced version of the currently existing controller with a focus on: Volume reduction (-20% compared to the currently existing controller), weight reduction (- 13%), reduction in production cost (- 50%), and the development of a modular and adaptive design.

These improvements will lead to system advantages compared with current solutions that will ensure Bultaco Motors a considerable market share and leadership not only in the electric motorbike market but also in the growing European and worldwide market for electric vehicle controllers specific for light traction applications that has shown a steady growth rate in 2012 of 11% . Adaptcontrol aims to position Bultaco Motors as a reference world-wide supplier for smart vehicle control systems with overall energy management and recovery capabilities. The power control unit modularity, dimensions and operation configurations will allow any OEM engineer to adapt it to a wide range of electric vehicle types such as the formerly mentioned ones. In such applications, where reduction of weight and volume is so important, having a unique unit for the entire vehicle control makes integration easier and more space effective.";2042725;1429907,5;H2020-SMEINST-2-2014;SME-2;BULTACO MOTORS SL;ES;;; 196472;672757;ESW;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;European Structural Wood - for sustainable building components;1/06/2015;30/11/2015;;"ESW proposal outlines the opportunity to develop an innovative technological process which will produce a new constructional material, having higher yields compared with the best alternatives in terms of technical results, economic and environmental footprint performances. That would make ESW advantageous competitor and feasible alternative as structural material representing the best performing material for supporting structure. ESW proposed technology uses Thermo Vacuum Wood (TVW) for manufacturing an outstanding new bio-material which has the potential to replace most commonly used structural materials such as concrete, steel and timber. This novel process will ensure the sustainable supply of raw European materials via extremely environment friendly new solution in construction industry, and will also provide participating SME with the opportunity to derive an ongoing income. The engineered ESW has better technical performances (more resistant, robust, seismic tolerant) in respect to raw wood, laminated wood (glulam), aluminium alloy, concrete.
Upon successful completion of this project, the likely benefits to the partners, end-users and society will include:
The ability for manufacturing large-scale ESW constructional components
Significant reduction in carbon emission and consumes of energy via elimination of tropical timber import from extra UE countries
Reduction of toxic and pollutant glues used for manufacturing wood laminated constructional components
Savings (up to 20% /m3) for multilayer constructional components compared with wood (non tropical) and glulam ones
Savings (up 70% /m3) compared with constructional structures made of tropical timber or other thermotreated woods thanks of the use of local European (low market value) wood.
ESW is made okf wood treated with Thermo Vaccum process and glue. Thermo Vacuum Process was funded by Eco innovation in 2012 and gives thermovacuum wood that is strategic for ESW material.";71429;50000;H2020-SMEINST-1-2014;SME-1;WDE MASPELL SRL;IT;;; 196317;664339;HEALTH-TECH;SIGNED;H2020-EU.4.a.;WIDESPREAD-1-2014;H2020;Centre of Excellence in Science and Technology for Healthy Ageing;1/06/2015;31/05/2016;;"In order to both solve the medical needs of ageing-populations in Europe, and develop an innovative ecosystem beneficial for the economy of Lithuania, it is proposed to foster the whole innovation chain in the area of healthy ageing from fundamental research through to the introduction of new products and services to the market - by creating in Lithuania a world-class Centre of Excellence (CoE) in science and technology for healthy ageing, named HEALTH-TECH.

The long-term vision for HEALTH-TECH is to:
- Become the leading provider of innovative medical solutions for the improvement of the health of ageing-populations in Europe,
- Consolidate research and development, education and training, and networking and promotion resources activities in the area of healthy ageing,
- Coordinate, integrate and support research excellence and innovation development in Lithuania, the Baltic Sea region, and Europe,
- Support researchers, physicians, and entrepreneurs in the field of healthy ageing science, technology and biotechnology to produce innovations beneficial for the society and economy of Lithuania and beyond.

To achieve this long-term vision, the CoE will leverage the knowledge, experience and resources of three Lithuanian universities KTU, LSMU, and VU - with the support of two advanced partners of the Baltic Sea region LUND in Sweden, and VTT in Finland - in four strategic research and innovation topics:

1. Mechanisms of age-related diseases
2. Biomarkers for age-related diseases
3. Diagnostics and monitoring technologies for age-related diseases
4. Regenerative technologies for age-related diseases

This project has the full support of the Lithuanian Government because it fits perfectly with the Lithuanian SMART Specialisation Strategy approved by the Government, and will allow an enhanced usage of the recently upgraded and newly built infrastructure for medical research in Lithuania.";465560;465560;H2020-WIDESPREAD-2014-1;SGA-CSA;KAUNO TECHNOLOGIJOS UNIVERSITETAS;LT;"VILNIAUS UNIVERSITETAS;LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS;LUNDS UNIVERSITET;Teknologian tutkimuskeskus VTT Oy";"LT;SE;FI"; 196370;665777;miRaColl;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;miRNA-activated Scaffold Technologies for Cartilage Regeneration;1/09/2015;28/02/2017;;Adult articular cartilage has a limited capacity for repair so when damaged it can lead to joint degeneration and ultimately osteoarthritis. In our lab we have had significant success in enhancing tissue regeneration by functionalising collagen-based scaffolds for the delivery of therapeutic genes. In this project we propose to apply this concept for the delivery of microRNAs to promote enhanced cartilage repair.;149450;149450;ERC-2014-PoC;ERC-POC;ROYAL COLLEGE OF SURGEONS IN IRELAND;IE;;; 196418;671852;RePack;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Reusable, returnable packaging for e-commerce;1/05/2015;31/10/2015;;"RePack is a sustainable packaging system for online retailers and shoppers whereby delivery packages can be conveniently and easily returned, and then re-used. It is a system level innovation and its business model consists of three elements: 1) Reusable design packaging; 2) Stock, deposit management, and track and trace software; and 3) Market place for voucher use.

In Europe alone 3,7 billion disposable packages are sent to consumers annually. Ecommerce market has evaluated market size as 312 billion Euros and growing at almost 20 % annually (Ecommerce Europe, 2013). For webstores disposable packaging is a wasted opportunity to improve consumer experience, increase consumer loyalty and improve their supply chain efficiency. This behavior is wasteful from the perspective of consumers, webstores, environment and society as a whole. RePack end users save money on their next purchase and web stores improve consumer loyalty while offering environmentally sustainable delivery alternative to disposable packaging.

The main specific objective of the feasibility study is to pilot RePack in other EU markets. This pilot is used to gather consumer and webstore feedback to identify benefits and analyse bottlenecks in the ecommerce value chain in EU markets. Our current analysis is that the main bottleneck is lack of awareness regarding our innovation outside Finland, limited sales channels, lack of e-commerce contacts and long sales and project cycles. This is especially related to fashion ecommerce. We want to further investigate these bottlenecks, increase awareness of our solution and accelerate Repack adoption cycles.";71429;50000;H2020-SMEINST-1-2014;SME-1;SUUNNITTELUTOIMISTO PERUSTE OY;FI;;; 196411;666810;Infantium 2.0;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Adaptive learning platform for personalized children education crossing cognitive and biometric inputs;1/05/2015;30/04/2017;;"The current educational system is not optimal - arguably even obsolete. At Infantium we are committed to bringing the latest advances in information and communication technologies to education in order to fundamentally change how our children learn.

Our proposed solution is an intelligent framework that gathers cognitive information related to the performance and interaction of kids as they consume educational content (such as APPs, learning videos, etc.) on tablets. The software monitors parameters such as the time required for a child to reach certain goals within the APP, or the time between two consecutive interactions in order to develop cognitive models.

Moreover, we monitor users biometric parameters using a bracelet device and a standard tablet camera to infer students emotions and gather behavioural information. Our main objective is to fuse cognitive and behavioural data, using our Artificial Intelligence-based technology. The result will be a unique system that is able to maximize learning ability using cognitive abilities and emotional motivation.

We are applying for funding through this program specifically to 1) miniaturize the bracelet prototype for comfort and ease of use, 2) modify and test the computer vision software with kids, using tablets, 3) fine-tune our algorithms to infer emotional states, 4) correlate the data from the wearable device and the vision algorithm, and 5) test the integrated system with kids during early childhood education.

We are requesting about 1.5M that will allow us to boost our growth by 45%, achieving an additional sales revenues of 11M and representing a ROI of 4 by 2020.";1483433,33;1038403;H2020-SMEINST-2-2014;SME-2;INFANTIUM SL;ES;;; 196372;665959;DIRS;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-DP;H2020;Deusto International Research School;1/01/2016;31/12/2020;;"With a proven track in PhD training (more than 1000 PhD in 50 years, 58 in 2013) the Deusto International Research School (DIRS) aims at attracting qualified international Early Stage Researchers for high quality PhD training that enhance research, complementary and transferable skills.
DIRS aims are grounded in a solid structure generated around a robust and dynamic ecosystem that encourages and enables cooperation, co-creation and collegiality among 7 doctoral programmes and 24 research groups around four research foci centred on challenges identified in the EU and the Basque Smart Specialisation Strategies: i) Health and Wellbeing, ii) Human Rights, Peace and Conflict Resolution, iii) Sustainable Development and Innovation and iv) Lifelong Learning.
UDEUSTO has actively and creatively procured conditions conducive to frequent dialogues between economic, cultural and social actors whose cooperation and exchanges help realise DIRS aims. These dialogues will ensure international and intersectoral mobility, including placements/internships to broaden ESR career employability tracks; cross-fertilisation of ideas and ideation of solutions to societal challenges fuelled by shared concerns and funding. 40 partners formally back DIRS project.
16 MSC PhD candidates will be selected via an open, transparent, merit-based, impartial, equitable and internationally advertised process that will take special care to avoid any form of discrimination. Upon acceptance, PhD candidates will sign an employment contract and will be hosted in an attractive environment to benefit from a shared supervision and mentoring process formally inscribed in the Doctoral Agreement and the individualized research/training development plan (Personal Career Development Plan).
Full internationalisation is an essential aspect of DIRS. The COFUND scheme will strengthen the European and International dimensions of the project by consolidating the current rate of ESR (31,25% of PhD students in 2013/2014)";2511360;1255680;H2020-MSCA-COFUND-2014;MSCA-COFUND-DP;UNIVERSIDAD DE LA IGLESIA DE DEUSTO;ES;;; 196371;665958;MWK-Fellows;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-FP;H2020;Fellowships in Advanced Cultural and Social Studies at the Max-Weber-Kolleg;1/09/2015;31/08/2020;;"The MWK-Fellows programme financed by COFUND aims to allow excellent incoming researchers from countries other than Germany (in accordance with the EU-mobility-rule) to conduct their own, freely chosen, independent research projects in a highly competitive and intellectually vibrant research environment provided by the Max Weber Center for Advanced Cultural and Social Studies (Max-Weber-Kolleg).
The Max-Weber-Kolleg is a high-ranking research centre which forms an avant-garde institution of the University of Erfurt. It is distinguished by a unique organisational structure combining the features of an Institute for Advanced Study and a Graduate School and a Weberian research programme. The Weberian research programme combines historical, comparative and interdisciplinary perspectives with an interest in normative issues in the social sciences. It has a focus on societal challenges of contemporary societies, especially (religious) plurality, cultural diversity and social order, processes of acceleration and growth. The core disciplines are sociology, economics, religious studies, law, philosophy and history, but MWK-Fellows programm is open for related areas as well.
The Max-Weber-Kolleg is based on the principles of interdisciplinarity and internationality with a long-standing and progressively fine-tuned fellowship programme. By means of the COFUND-action Max-Weber-Kolleg will not only increase the number of international fellows but include a new intersectoral dimension into its fellowship programme.
At the Max-Weber-Kolleg, MWK-Fellows will enjoy the best possible support and an opportunity of being connected with larger research projects. Nevertheless the applicants freedom of choice of the research project is fully guaranteed.
The MWK-Fellows programme will improve international high-level research and science with and for society and will contribute to the fostering of the European Research Area (ERA), especially in the field of societal challenges.";2832000;1416000;H2020-MSCA-COFUND-2014;MSCA-COFUND-FP;UNIVERSITAT ERFURT;DE;;; 196458;672615;AgroPellet;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Development of a pelletising machine to process multiple-source agricultural mixes;1/05/2015;31/10/2015;;"100 million tons of agricultural residues are sustainably available per year for the production of energy in the EU, corresponding to 3.2 % of the EUs final energy consumption. One promising way to use this potential is to pelletise the residues for their combustion in CHP plants. This potential is not used, though, as most farmers produce a variety of different residues and none of the currently available pelletising machines is able to process them all simultaneously.
Pusch GmbH & Co. KG has developed an innovative new technology which allows the processing of all kinds of agricultural residues as well as mixtures of residues occurring in the EU. A first technical prototype has demonstrated the proper functioning and huge potentials of the technology. However, improvements and adaptations are required to achieve the market breakthrough. In this proposed project a feasibility study will reveal the technical feasibility of the envisaged improvements and the optimal way of implementation, while a business plan will show the optimal way of commercialisation.
The new pelletising machine will allow the European farmers to use the full energetic potential of their residues and therefore significantly increase their income while at the same time helping Europe to reach its goals of climate control. At current market prices for pellets an additional turnover of 14 billion per year can potentially be generated at EU level and up to 137 million tons of CO2 can be saved compared to fossil fuels. At the same time Pusch GmbH & Co. KG will be able to significantly grow in terms of turnover, profit and employees and to establish itself on the European market for renewable energy technologies.";71429;50000;H2020-SMEINST-1-2014;SME-1;PUSCH GMBH & CO KG;DE;;; 196374;666010;TOPMed10;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-FP;H2020;Fellowship Programme supporting Career Development and Interdisciplinary Training in Omics driven Personalised Medicine;1/07/2015;30/06/2020;;UCD proposes the implementation of a new postdoctoral fellowship programme supporting career development and interdisciplinary training in omics driven Personalised Medicine for 10 high calibre experienced researchers undertaking transnational incoming mobility to Ireland (TOPMed10). Experienced researchers, by definition under Marie Sklodowska-Curie Actions (MSCA), are those in possession of a doctoral degree (or at least 4 years of research experience (FTE)) at the time of the deadline for the submission of their fellowship proposal. TOPMed10 offers 10 prestigious fellowships, 2-3 years in duration, across two calls. Fellowships will be offered at 2 levels: level 1 will be targeted at incoming experienced researchers (as per MSCA definition) with 0-3 years additional research experience and level 2 will be targeted at incoming experienced researchers (as per MSCA definition) with 3\ years additional research experience. Career breaks will be taken into account. Fellowships of level 1 and 2 are open to candidates of any nationality who, at the time of the deadline for submission of proposals, shall not have resided or carried out their main activity (work, studies, etc.) in Ireland for more than 12 months in the 3 years immediately prior to the deadline for submission date. Compulsory national service and/or short stays such as holidays are not taken into account. Fellowships will be based in the UCD Research Institutes (Systems Biology Ireland, UCD Charles Institute of Dermatology, UCD Conway Institute of Biomolecular and Biomedical Research and the UCD Clinical Research Centre). Fellows may undertake an optional 3-9 month secondment to a Partner Organisation (incl. academic, industry, clinical sector) or a research performing organisation in any country in the world deemed to be appropriate in terms of meeting the needs of the fellows research, training and career development requirements.;1770000;885000;H2020-MSCA-COFUND-2014;MSCA-COFUND-FP;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;IE;;; 196457;672614;SmartX;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;SmartX is an innovative ICT platform for electricity demand-supply management;1/05/2015;30/09/2015;;"SmartX - an innovative ICT platform for electricity demand-supply management allows energy suppliers to optimize their operating costs on one hand and reduce electricity bills for their customers on the other. SmartX consists of a central control unit that makes energy supplier able to control energy consumption and generation at the level of single houselhold. For example energy vendor may be interested to limit some non-critical energy-consuming assets at the peak time (like air conditioning when nobody is at home) or maximize home-based PV installation capacity of its customer at the peak time.
Thanks to that, the vendor is able to buy less energy in the wholesale market at the peak times. Yielding control over some consuming/producing assets brings value to vendors' final customers - they will be able to pay less for the energy (less consumption in peak times) and/or get better price for the green energy they produce at home and they will not need to pay any attention in order to achieve that. Moreover vendors will probably offer better tariffs to the customers connected to SmartX as the cost of supply-demand risk management for such group of customers will be much cheaper.";71429;50000;H2020-SMEINST-1-2014;SME-1;CONNECTPOINT SP ZOO;PL;;; 196425;671978;Paediatric LMS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Non-Invasive Quantitative Magnetic Resonance for Obese Children the Paediatric LiverMultiScan Test;1/06/2015;31/10/2015;;"As for adults, chronic liver disease is children is a major, rapidly growing health problem. The main causal factor is obesity, leading to fatty liver disease and non-alcoholic steatohepatitis. Inadequately treated children with liver disease will impose a disproportionate life-long burden on a nations healthcare system. In the EU, one third of adolescents is overweight/obese. Current techniques to diagnose and monitor liver disease in children are poor, insensitive or invasive. Liver biopsy is painful, costly, and samples only a tiny fraction of the liver. Perspectum Diagnostics is a University of Oxford spin-out founded by world-leading clinical and engineering experts in MRI. They have developed a quick, non-invasive MRI test that measures accurately the main features of liver pathology. Clinical trials in adults show excellent diagnostic performance and reproducibility. Perspectums first product, LiverMultiScan (LMS), is CE-marked for diagnosis of adult liver disease. We propose substantial modification of LMS for liver disease in children/adolescents. This requires adaptation and optimization of the methods in LMS, not least definition of thresholds and grading of disease, and analysis/presentation of results. A multicentre clinical trial is needed to obtain solid clinical evidence of diagnostic efficacy and cost-effectiveness of Paediatric LMS. We will develop a study design with a clinical trials unit; establish a network of EU clinical sites; ensure recruitment and technical feasibility at each site; cost the clinical study; establish economic viability; obtain more precise estimates of market size and growth rates, as well as the economic benefit to users. Paediatric LMS can become the standard test for assessing chronic liver disease in children, presenting not only a huge economic opportunity, but also the chance to greatly improve liver health in EU children. We will deliver a business plan for a subsequent phase 2 application.";71429;50000;H2020-SMEINST-1-2014;SME-1;PERSPECTUM DIAGNOSTICS LTD;UK;;; 196355;665633;BLOBREC;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;A gene expression test in blood for breast cancer;1/05/2015;30/04/2016;;"The aim of BLOBREC is to develop a blood-based test for the diagnosis of breast cancer. The test is based on results from gene expression analyses in a hospital based nested case-control study in the Norwegian Women and Cancer postgenome cohort study. The controls are healthy population controls from the same cohort. The innovative potential of a gene expression test is the independency from other test for breast cancer like imaging technologies (mammograms, ultrasound, MR) and pathological diagnosis. As such it could be used by itself or in combination with these other technologies. The idea has been considered by the International Search Authorities to be novel and inventive and thus, considered to be patentable.
Further analyses should be run to improve the predictive values of the test together with an external validation. The scenarios of use will be discussed. Based on this work comprehensive documentation should be available for commercial partners. Through collaboration with a technology transfer institution the potential approaches to commercial companies should be explored before any negociations.
The idea could have important social and clinical implications through improved diagnosis of breast cancer given the increasing incidence of this disease in many countries worldwide.";143933;143933;ERC-2014-PoC;ERC-POC;UNIVERSITETET I TROMSOE;NO;;; 196302;664047;SEMICOOL-H;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Hybrid cooling system for semiconductor detectors of X- and Gamma- Rays;1/04/2015;30/09/2015;;"Semiconductor detectors for x- and gamma-rays registration are widely used in nuclear energetic and ecology, geology and mineral resource industry, medicine and scientific research activities, other spheres. To provide the best performance in all applications, HPGe and SiLi detectors require a cooling till liquid nitrogen (LN2) temperatures. In general cooling system semiconductor detectors are installed in vacuum cryostat which is submerced to Dewar vessel with LN2. In the process of using LN2 there is constant boiling and evaporating of LN2 and therefore there is a permanent necessity to control a LN2 level in Dewar vessel and to fill it with the certain periodicity. Typical periodicity for 20-30 l volume change is once per week. Refilling these volumes is problematic due to its need for permanent attention and that automatic filling requires special expensive equipment. This proposal declares a technology where refilling of LN2 is needed with much lower periodicity (about once in a year). This hybrid cooling system includes cryostat with semiconductor detector, Dewar vessel with LN2 for detector cooling and electrical cooler for condensation of evaporated LN2. Such system should be hermetically closed. The current system provides the re-use of resources (LN2) so giving the contribution in the sustainability of resources and energy efficiency.
The following project realizes the feasibility study for the development of advanced hybrid cooling system for semiconductor detectors.";71429;50000;H2020-SMEINST-1-2014;SME-1;BALTIC SCIENTIFIC INSTRUMENTS SIA;LV;;; 196403;666635;TRADECC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;TRADExpress Client Clearing;1/04/2015;30/09/2016;;The objective of this project is to create a real-time risk margining and multi-asset client clearing product for banks. Banks and their clients will receive an instant and complete view of their risk exposure, which will enable them to use posted collateral efficiently across all markets they trade a disruptive shift in the client clearing business, moving from batch to real-time clearing.;3148200;2203740;H2020-SMEINST-2-2014;SME-2;CINNOBER FINANCIAL TECHNOLOGY AB;SE;;; 196396;666507;ADVANCED-BIPV;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;NEW GENERATION OF BIPV-GLASS WITH ADVANCED INTEGRATION PROPERTIES;1/04/2015;31/03/2017;;This project proposal starts to walk pursuing to accomplish the following main general objective: to overcome the main limiting factors of BIPV technology strengthening its competitiveness by developing new generation PV glazing satisfying the well-defined market demanded architectural trends. ONYX will face this main goal by developing a new family of products referred as Novel XL-BIPV glazing units, High-Mechanical Resistance PV units and high performing vision glazing based on PV thin film transparent panes (transparency over 50%) being market ready within the 24 forthcoming months. During the lifetime of the project, main challenges will be faced and overtaken by well-defined approaches. Out of the technical challenges ONYX will establish a very well defined commercialization and marketing strategy targeting global markets and main green building and architectural glazing stakeholders. ONYX ambition will be reaching the blue ocean concept. In other words, by developing BIPV products with undeniable added value achieving a clear market differentiation from our competitors leading to a greater range of coverage of the architectural glass industry, gaining the attention of prestigious end users as clients, and promoting a sense of market dominance by offering products that others cannot. The final goal will be achieving a 4,3% market share of the global BIPV business by 2020. It means to double or quadruplicate our actual share of 1% in a market that will grow from $823 million ($US) in 2014 to $2.7 billion in 2019 (30% growth/per year). On the other hand, it should be pointed out that this project proposal fits perfectly with general EU policies in terms of sustainability as for instance Energy Performance of Building Directives. In summary, by executing this project ONYX seeks to become a world leader not only in BIPV, but also in high-performing architectural glazing and Green Building Sector developing BIPV unique solutions.;2695887,5;1887121,25;H2020-SMEINST-2-2014;SME-2;ONYX SOLAR ENERGY S.L;ES;;; 196358;665619;MicroMap;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;A new instrument for mapping the ultrafast photo-conductivity of materials for optoelectronics;1/09/2015;28/02/2017;;The introduction of new photo-active materials with enhanced performance is enabling a fast technological development in fields such as photovoltaics, photodetection, display technology and imaging systems. The efforts on the improvement of the synthesis and growth of these materials are in many cases not accompanied with equal efforts on the development of appropriate techniques that enable their characterization. MicroMap aims to develop a commercial instrument for the contact-free characterization of the high frequency photoconductivity of materials. The demonstrator will consist of an optically pumped near-field microscope and far-field spectrometer to map the response of photo-excited materials over areas of varying size from micrometers to several centimeters. This unique combination of length scales will enable to probe the conductivities of full devices and to determine the conductivities and carrier life times in single or few nanostructures or small areas to define the microscopic origin of the factors limiting the photoresponse. To demonstrate the feasibility of the instrument for the characterization of materials, we plan to test it on novel materials being currently investigated for optoelectronic applications. These include graphene, nanowires and perovskites. These tests will be used to elaborate technical notes that will help the commercialization of the instrument. The outcome of this project will be licensed to Protemics GmbH, which is a privately held spin-off of the research company AMO GmbH and the Institute of Semiconductor Electronics (RWTH Aachen University) with a background of two decades in THz technology . The target market for the instrument is academic and industrial research organizations working on materials research. We will also carry out a detailed business analysis to identify broader possibilities, e.g., for material characterization in industrial production or for THz sensing.;148750;148750;ERC-2014-PoC;ERC-POC;STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN;NL;;; 196356;665725;IONOSENSE-POC;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Exploitation of Organic Electrochemical Transistors for Biological Ionsensing Proof Of Concept;1/04/2015;30/09/2016;;The IONOSENSE-POC project proposes a novel solution to enable label-free, electronic monitoring of live cells in vitro, using innovative organic bioelectronic technology. The device, the organic electrochemical transistor (OECT), integrated with live cells forming a tissue, has been shown to accurately assess the integrity of the cells, providing dynamic, highly sensitive measurements after exposure to toxins/pathogens. Validation against traditional, optical methods, or commercially available electronic monitoring equipment demonstrated the OECT to have equal or improved sensitivity and temporal resolution. As an added bonus, the OECT is fabricated using conducting polymers, which are not only amenable to low cost processing techniques, but are also optically transparent, yielding devices compatible with high resolution imaging techniques, of critical importance to life scientists. In the POC project, we propose to take this extremely promising technological breakthrough developed in an academic environment, and transition it to a prototype suitable for future commercialization. In parallel, the appropriate steps will be taken necessary to ascertain the market niche(s), initially identified as being in the areas of Biomems targeted for diagnostics/drug discovery. Finally, an adapted exploitation strategy will be developed to best suit the technology developed during the IONOSENSE project. The team assembled to execute the project is extremely committed to the commercialization venture, in particular due to significant feedback from industrial partners (potential endusers) from such diverse biomedical applications as the cosmetics industry, neurotoxicology, electrophysiology instrumentation developers, drug development companies etc. The success of this POC project will have broad ranging, highly positive impacts for society in the EU and further, due to reduction of experimentation on animals, improved healthcare outcomes, and economic development to name a few.;149673;149673;ERC-2014-PoC;ERC-POC;ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS;FR;;; 196273;663655;FlowcusinUp;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Scale Up of Microencapsulation Systems by using Flow Focusing Technology;1/02/2015;30/06/2015;;"FlowcusinUP global innovation project aims at designing an innovative Microencapsulation industrial-strength system sufficiently scalable, adaptable and versatile to fulfil new market opportunities.

Ingeniatrics is a highly innovative SME with extensive background in micro-and-nanoscale market and technologies, and with an Intellectual Knowledge protected by over 80 national and international patents (and applications). Despite his proven track record, Ingeniatrics current laboratory-based manufacturing facility couldnt afford the increasing demands of the fast-growing microcapsules market.

FlowcusinUP industrialization will improve the efficiency in the process of manufacture, driving Ingeniatrics to produce monodisperse particles with a core-shell full protection and sizes below 100-150 microns. At this moment, there is no system capable of producing microcapsules with ultimate features that allow the patented technologies from Ingeniatrics and with efficient quantity/cost ratio to address industry-wide production.

The present FlowcusinUP Phase 1 will undertake technical, economical, operational and marketing-related analysis to validate the profitability of the solution and successful access to global market. At the end of phase 2 FlowcusinUP foresees a reduction of production costs of approximately 50 times, and reduction of production time around 150 times compared to current systems.

The future commercialization of the FlowcusinUP outcomes will strengthen EU microparticles ecosystem and related applications (nutraceuticals, agrochemical, pharmaceutical, food, textiles, paper industry...) and will booster Ingeniatrics to a leading position within the microencapsulation market.";71429;50000;H2020-SMEINST-1-2014;SME-1;INGENIATRICS TECNOLOGIAS S.L.;ES;;; 196443;672421;Heat2Energy;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Demonstrating a highly-efficient and cost-effective energy conversion technology for waste heat recovery;1/05/2015;30/09/2015;;"The project presents a new energy conversion technology for low-grade waste heat recovery. It transforms thermal energy (80C - 400C) from different heat sources on demand either in mechanical, electrical energy or higher/lower temperature levels. The working principle is: Due to a waste heat supply a working medium expands against a working fluid and against the Energy Converting Unit that works as a hydraulic engine to generate different kind of energy forms. Heat2Energy achieves much higher overall efficiencies of >20% than conventional technologies like ORC. The users can be found world-wide, where ever thermal processes happen. They are either application-specific end users (private, public organisations, individuals), components manufacturers for integration in their own products/processes or system manufacturers. Depending on the heat source advent, the potential markets are: Industry (waste heat recovery; efficiency increase of existing power plants), Home (energy efficiency increase of buildings), Renewables (solar thermal, biomass, geothermal) and Mobility (energy-efficient drives for ships, locomotives and trucks). The commercial potential to recover the industrial waste heat in Europe is estimated at 2,000 PJ/a. In Germany, the market value of waste heat recovery exceeds 25 Billion/a. It is a growing high volume market as applications are so manifold across many sectors. The economic benefits are substantial energy cost savings, reduction of GHG emissions and the possibility of operating energy-autonomous applications. The technology significantly contributes to the sustainable use of natural resources and to secure and decarbonise the European energy system including the integration of renewables. The feasibility assessment shall prepare the demonstration of the technology in the cement industry to provide mechanical drive for the screw-type compressor to generate compressed air, to elaborate the business plan and to finally promote the technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;THERMOLECTRIC INDUSTRIAL SOLUTIONS GMBH;DE;;; 196399;666566;GT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Green battery-less Tire Pressure Monitoring System;1/04/2015;31/05/2017;;"The main objective of the project is the growth and internationalization of FARSENS by the development of a Tire Pressure Monitoring Systems (TPMS), an electronic system in charge of the monitoring of the wheels air pressure, providing a real-time information. This information is very useful in regarding security, but also in terms of gas consumption, and thus in terms of reducing air pollution. Besides the intrinsic interest of this system in relation to security and environment, it is also mandatory by legislation to be installed in all the new cars in the USA and it will be mandatory by the end of 2014 for all new models, what makes an increment of around 50 million vehicles equipped with this system until 2015. Taking into account 4 devices per vehicle, it turns out in 200million TPMS units.
This project will lead the company growth for the next years from a high technology solution developer to an important stakeholder in automotive industry. During the last years the main strategy of the company has been focused on creating a reliable structure in order to ensure the success once one of the developed products entries the market. This project is natural as it is the next logical step to develop its strategy. FARSENS battery less solution meets all technical specifications and minimizes costs due to:
1-Cost-effectiveness (less subcomponents and the new design makes it half the actual cost). FARSENS solution is based on a battery less system and a 99% of inclusion of the sensors functionalities in only one ASIC. These decreases the cost of the components and assembly cost.
2-Saving due to less waste management and easier recycling (there is not battery), without compromising the quality or the service.
Thanks to the SME instrument, 2017 could be the year with the first sales, with an estimated 28% profit (0.55 M) and during 2018 it is estimated an accumulated balance of 0.5 M, being the ROI only 2 years.";803462,5;562423,75;H2020-SMEINST-2-2014;SME-2;FARSENS, S.L;ES;;; 196361;665522;PhotonCount;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Imaging with Photon Counting: Reduced costs, increased dynamic range;1/04/2015;31/03/2016;;Optical methods and fluorescent proteins to probe and manipulate cellular and subcellular processes have proven to be a major driving force behind many recent breakthroughs in biology and medicine. Recent developments in photonics have led to increased spatial and temporal resolution and now allow the study of single identified synaptic contacts between neurons as well as large-scale neuronal networks. Brain tissue strongly scatters light. Thereby, the amount of light emitted by fluorescent probes in small structures inside neuronal tissue that reaches the microscope objective is small. Fluorescence imaging in living tissue, as I use in my ERC-funded research program, is therefore limited by low signal-to-noise levels. One approach in increasing the level of such weak fluorescence is to increase the excitation power, but this has the undesirable effect of bleaching the fluorescence faster and damaging the cell. Another approach is to optimize the fluorescence collection by using high-end microscope objectives in the 20,000 eur range with improved light transmission, high numerical aperture and low magnification that can collect fluorescence more efficiently. Although these objectives brought a significant improvement to imaging applications, physical limitations in their design cannot offer anymore a similar qualitative improvement as previously. Since there is a great need to further improve biological imaging, the present proof of concept application aims to achieve this by developing advanced, but low-cost, electronics for the optical detection of weak fluorescence signals through Photon Counting, and bring this technology to the market.;147500;147500;ERC-2014-PoC;ERC-POC;STICHTING VU;NL;;; 196359;665412;XMED;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Medical Phase Contrast X-ray Imaging with Laser Plasma Accelerator;1/04/2015;30/09/2016;;Cancer detection at an early stage is crucial for subsequent therapy success. To achieve this goal, an effective screening should rely on a specific tool that should be not only non-invasive but also adaptable to patients and their diseases. Widely used nowadays, X-Ray imaging (RX) is a well-established cancer screening technique. However, it poses major problems of (i) detection of tumours at early stages when they are small and of low contrast, (ii) dose deposition in a body, especially for frequent and long term monitoring and (iii) energy tunability of the X-ray source to optimize the imaging. The project XMED aims at tackling simultaneously these three strong limitations, and to come out within 18 months with a demonstrator. For this purpose the most advanced electron beams produced by laser plasma accelerators will be use to radiate a bright, tunable X ray beam using the recent all optical Compton scheme.;149851;149851;ERC-2014-PoC;ERC-POC;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196442;672390;SLIGHT GRANULATION;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;SLIGHT GRANULATION process reducing Water consumption in ceramic tiles industry;1/06/2015;30/11/2015;;"The objective of SLIGHT GRANULATION project is to validate on the market an innovative production process, reducing both the use of water in ceramic industrial processes and the energy consumption. The new process will address a specific phase of production chain (i.e. granulation), reducing by 40% the use of water and completely cutting off the energy consumption in this phase.
Before taking the final go to market decision, it will be necessary to carry out a wide and extensive market and feasibility study aiming at setting up the main economic and technical drivers leading the subsequent market deployment phase. While initial test have been already carried out through a pilot plant in small scale, the objective of the overall innovation program will be to set up a wider piloting phase, involving industrial actors that may support Manfredini and Schianchi in fine tuning operational parameters of Slight Granulation process. The objectives of the feasibility study will aim at obtaining direct feedback from potential users, before starting the full industrialization of the process. The low level objectives will be:
- to lead at least 15 interviews with potential customers
- to define a panel of at least 4 users to be involved in innovation phase
- to clearly define functioning parameters of Slight Granulation process
- to carry out a (preliminary) P&L for Slight Granulation plant business line;
- to monitor IPR issues
- to define technical road map for innovation phase.
The results of the validation study will be enclosed in a Business and innovation plan, that will be submitted as main deliverable at the end of the project.";71429;50000;H2020-SMEINST-1-2014;SME-1;MANFREDINI & SCHIANCHI SRL;IT;;; 196340;664876;GSVRotor;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Development of the Gas-Solid Vortex-Rotor Reactor;1/06/2015;30/11/2016;;The project includes Proof-of-Concept research, as well as preparation and submission of a new patent application. The intention of the current proposal is to develop a novel gas-solid reactor that drastically reduces the limitations of these reactors. Moreover, novel fields of applications will be sought. This new Intellectual Property of UGent will be a subject of its following licensing.;149900;149900;ERC-2014-PoC;ERC-POC;UNIVERSITEIT GENT;BE;;; 196287;663862;WISE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;WISE Wide Instantaneous Support Equipment;1/02/2015;31/07/2015;;"In the aviation industry, the downtime of aircrafts due to maintenance operations, also called Aircraft On Ground (AOG), represents a huge economic loss for airline companies. Each 24 hours of AOG can cost up to 100 000$ to the company . While the repair of electronic circuits often takes only a few minutes, repairing a part of an aircrafts structure can range from a couple of days to several weeks. The WISE (Wide Instantaneous Support Equipment) project aims at accelerating and improving structural repairs on aircrafts.

In the current market organisation, structural repairs require onsite specialized expertise. As experts are not available in every airport, they often have to be flown on site and this creates costly delays. Instead of physically moving the experts, WISE will bring expert assistance to the onsite teams through an advanced augmented reality communication system. Any maintenance site will then be able to benefit from the cumulated expertise of SUNAERO, which provides better results than any individual expert and avoids the added inconvenience of delaying the repair. Air flight security will be improved and costs reduced.

The WISE project stems from repeated requests from customers, challenging us to devise a device capable of bringing world-class expertise to their onsite general maintenance teams. As the financial and technical benefits of such a solution are quite obvious, the goal of this feasibility study is to prove that such a feat is achievable.";71429;50000;H2020-SMEINST-1-2014;SME-1;SUNAERO - HELITEST;FR;;; 196381;666167;HTPush;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014;H2020;Universal and compatible system for plumbing and heating;1/04/2015;30/11/2016;;"Current trends in the global construction market show a scenario in which sustainability and modularity are the predominant concepts. These trends are shifting the value chain of this sector towards economic, strong, fast and versatile construction systems. In this line, accessories for quick connection of pipes (fittings), known as push-fit fittings, have great advantages over conventional ones. However, their use is limited because they are neither universal (usable for any kind of pipe) nor compatible (valid to be used with pipes of any manufacturer).
At Hita Technology of Plastics Systems, S.L. we aim to develop and commercialise a complete family of push-fit fittings and flow regulators (HTPush) for potable water, plumbing heating, floor heating and radiator systems, intended to remove current shortcomings, offering end users a comprehensive solution to build complete installations to transport fluids from the general water network to the discharge point regardless from the pipe material and/or its manufacturer.
These accessories will be developed (in line with topic NMP-25) making use of advanced polymeric materials, and novel and exclusive manufacturing methods. It will also based on a new, patented technology developed by our company (WO/2014/072539).

Through this development our company expect introduce an innovative product into the market carrying out exploitation and diffusion activities during the project. As a result, it is expected an important growth for our company reaching a 2,4% market share, multiplying our sales by 10 and obtaining a total profit of 12,5 M in H2020. Also it is expected an induced benefit for UE, 42,75 M reached in H2020, derived from savings for end users, energy and waste savings and benefits from exportation.";1628900;1140230;H2020-SMEINST-2-2014;SME-2;HITA TECHNOLOGY OF PLASTIC SYSTEMS SL;ES;;; 196342;664926;FLOODSAFE;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;ASESSMENT AND INITIAL STEPS FOR THE EXPLOITATION OF A SIMULATION SOFTWARE FOR THE STUDY AND MITIGATION OF THE EFFECT OF FLOODS ON CONSTRUCTIONS AND LANDSCAPE;1/07/2015;30/06/2016;;"In the FLOODSAFE PoC we will explore the industrial applicability and potential for commercialization of the computational technology developed in the SAFECON Advanced Grant project for the study and mitigation of the effect of floods on constructions and landscape.
The SAFECON technology will help engineers to the enhanced design, building and maintenance of new protective constructions under extreme floods, as well as for the surveillance, risk management and monitoring of existing constructions and landscape in flooding situations.
The FLOODSAFE PoC will greatly help move the SAFECON software technology towards the initial steps of an innovation process leading to a new software for study of particulate mudflows and their interaction with constructions and landscape with the ultimate aim of ensuring the safety of existing and new civil infrastructures and the environment during floods.
In FLOODSAFE we will test the SAFECON software for solving practical cases of the effect of floods on constructions and landscape, define end user requirements, identify market needs, select potential users and define the roadmap for transfer and commercial exploitation of the software.";149856;149856;ERC-2014-PoC;ERC-POC;CENTRE INTERNACIONAL DE METODES NUMERICS EN ENGINYERIA;ES;;; 196379;666102;IF-EBOla;SIGNED;H2020-EU.3.1.;Health;H2020;Control of the Ebola Oubreak by both innovative Ultrasensitive Detection of EBOV and therapy;1/11/2014;31/10/2017;;"IF-EBOLa has been strategically designed to efficiently respond to critical needs required to control the current EBOV outbreak from spreading. The work will involve two of the main EVD outbreak sites, Sierra Leone and Guinea. MDs, public health authorities and virus experts working on site, under ethical regulatory rules, will extend their collaboration to companies and institution to form a consortium of outstanding complementary partners, sharing their innovative technological approaches for a common goal.

Our project aim is to contribute to provide an innovative early and accurate diagnostic for an early treatment and includes 2 phases: (I) a phase of preparation including, ethical authorizations, antibody production, technical and field organization as well as the beginning a follow-up of the homeostatic profile of contacts early-EBOV diagnosed and self-cured convalescent individuals in the absence of existing treatment, (with an ultrasensitive detection method of pernicious microorganisms, from the EC USDEP project qualified as a European success story USDEP project in 2010 by the EC-Project Officer) and (II) using a wide validated approach revisited with an innovative concept (strongly supported EC/EMA-WHO), we propose to carry out an experimental passive-immune therapy based on neutralizing capacity of horse anti-EBOV polyclonal F(ab)2 on early-diagnosed patients (n>300 that will be adapted in function of the epidemic situation) to impact and reduce their pre-existing viremia, their mortality, the evolution of their homeostasis profile, during and after this treatment (once patients become convalescents). The homeostasis status evolution will help to generate high quality scientific data to understand the EVD, the effect of this therapy and cure parameters characterized at 3 different levels: immune (transcriptomes, NGS, metagenomics); infectious (other than EBOV, DNA arrays), and EBOV diversity (sequencing and metagenomics).";2037770;1992770;H2020-Adhoc-2014-20;RIA;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;FR;"METABIOTA INC;ORION INTEGRATED BIOSCIENCES INC.;BEN-GURION UNIVERSITY OF THE NEGEV;ISTITUTO NAZIONALE PER LE MALATTIEINFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERESCIENTIFICO;FABENTECH;ABSISKEY CP;UNIVERSITY OF MANITOBA;INSTITUT PASTEUR";"US;IL;IT;FR;CA"; 196258;663503;MDLab Ginestra;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;A novel characterization- and reliability-oriented simulation software for dielectric-based nano-electronic devices;1/02/2015;31/07/2015;;"MDLab (Modeling Dielectric Laboratory) has developed a novel micro- and nano-electronic devices simulation software focused on the physical phenomena occurring in the dielectric layers i.e. charge and ion transport, charge trapping, and structural degradation. The MDLab software has several distinctive features (i.e., automatic interpretation and calibration, full reliability simulation, focus on dielectric-based devices with a multi-scale atomic approach, flexible graphical interface resembling a measurement instrument) compared to the TCAD software available on the market, which represents a great opportunity to successfully enter the market by responding to needs currently not covered by competitive commercial TCAD tools. Thanks to a novel user interface concept designed to be intuitive, a broad adoption of the software is expected from non-simulation-experts, who can benefit from the Graphical User Interface (GUI) simplicity, allowing connecting the electrical curves to the atomic/physical properties of the dielectric materials in an intuitive simulation environment.
MDLab aims at becoming an European and worldwide company developing simulation software for electronic devices, changing the way simulation tools are used in the semiconductor industry, thanks to the friendly and flexible interface connecting electronic device performance/reliability to atomic device properties.";71429;50000;H2020-SMEINST-1-2014;SME-1;MDLAB SRL;IT;;; 196428;672027;HUMICE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;AXENIS Humanized Mice Innovation towards industrial scale-up;1/05/2015;31/10/2015;;"Since 2010, AXENIS has developed proprietary, state-of-the-art humanized mouse models as preclinical tools for biomedical research and biopharmaceutical industry in the field of immunology, infectious diseases, immuno-oncology and inflammation. Humanised mice are extremely attractive and effective to perform a fine evaluation of new therapeutic and diagnostic options in a human-like environment. Overall, humanized mouse preclinical testing benefit to the patients (safer products) and pharmaceutical companies (upfront pre-clinical screening of molecules reducing clinical development costs).
To become a global European leader addressing the health market needs for humanized mouse models, the humanized mouse production activity of the company requires to be scaled up to an industrial level that will better suit the end-users expectations. That is a reason why a feasibility study is needed to help AXENIS accessing a comprehensive survey of production scale-up (at least 10-fold) from current low scale level (few hundred units per year) to the level of multiple of thousand units per year under optimal regulatory standards; an evaluation of the production costs with the aim of lowering the unit price by at least two; precise valuation of the demand market segments; and a risk assessment of the scale-up project.
The HUMANMICE project is therefore the basis to the future development of the company, to establish humanized mice as a new standard for preclinical studies, develop the next generation of humanized mouse models, create an environment supporting business & collaboration opportunities, minimize the production costs and maximize the corresponding revenues.";71429;50000;H2020-SMEINST-1-2014;SME-1;AXENIS;FR;;; 196341;664910;FORECAST;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;ASSESSMENT AND INITIAL STEPS FOR THE EXPLOITATION OF A FAST SIMULATION SOFTWARE FOR CASTINGMANUFACTURING OPERATIONS;1/05/2015;30/04/2016;;"In the FORECAST PoC we will explore the industrial applicability and potential for commercialization of the new fast simulation technology developed in REALTIME for the enhanced design of mould filling processes in casting manufacturing operations of mechanical components.
The computational technology tested In the FORECAST PoC will allow the casting industry, and in particular SMEs, to solve mould filling problems in times useful for taking decisions helping the design and operation of casting processes. In addition the REALTIME technology will allow users taking into account the multi-fluid character of mould filling processes, including coupled thermal-flow effects in both the air contained in the mould and the molten metal and heat transfer between the flowing melt and the mould walls.
The FORECAST PoC will greatly help move the REALTIME software technology towards the initial steps of an innovation process leading to a new extremely fast and accurate mould filling simulation software for enhanced design of casting manufacturing operations of mechanical components for a wide range of applications in industry";149963;149963;ERC-2014-PoC;ERC-POC;CENTRE INTERNACIONAL DE METODES NUMERICS EN ENGINYERIA;ES;;; 196365;665656;ACOFORS;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Launching Acoustic Force Spectroscopy - unlocking the potential of biomolecular bungee jumping;1/07/2015;30/06/2016;;"ACOFORS has been designed with the ultimate goal of preparing commercialisation of Acoustic Force Spectroscopy (AFS). AFS is a completely new and powerful technique for determining biomolecular mechanics and structure of single molecules such as DNA and proteins. These studies are performed on a large scale by biologists and within pharmaceutical companies for e.g. drug discovery and development. Current technologies for force spectroscopy (FS) represent a $50\ million market, but are expensive, require high levels of specialism and are laborious. AFS, invented in the laboratory of Prof. Wuite, is much simpler to use, can be operated in high-throughput mode and can become available at relative low cost. As such, AFS vastly expands the possibilities of FS and makes it available to a much wider community. This makes AFS a very attractive technology for science and business, both from the perspective of the user and of the seller.
In ACOFORS, a team of scientists and business developers will transform the current prototype in a marketable product, strengthen the intellectual property position, build a solid business case based on an extensive market analysis and take steps towards licensing the technology to industry.";150000;150000;ERC-2014-PoC;ERC-POC;STICHTING VU;NL;;; 196346;665215;EMOTION;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Electric-field driven magnetic domain wall motion for memory technologies;1/04/2015;30/09/2016;;Memory technologies that are used in computers, smart phones, tablets, etc. can be coarsely divided into two classes: fast but volatile DRAMs (dynamic random access memory) and non-volatile flash memories. Racetrack memory based on the controlled motion of magnetic domain walls is a promising new technology for next generation memories, because it combines the speed of DRAMs and the non-volatile properties of flash memories. One key drawback, however, is the required use of intense electric currents to move magnetic domain walls along narrow wires, which causes undesirable heat dissipation and considerable power losses. With this ERC proof-of-concept proposal, we aim at exploring the empty technology space around a recent invention in our laboratory, namely the ability to drive magnetic domain walls using electric fields (i.e. voltages) rather than electric currents in ferroelectric-ferromagnetic bilayers. Since no electric currents are flowing through the insulating ferroelectric layer during prototype device operation, power consumption and heating are minimal. Moreover, electric-field control of magnetic domain wall motion in our experimental demonstrator is deterministic and completely reversible. Using the ERC proof-of-concept grant, time and money will be invested for obtaining IPR protection for this new technology, different ways for industrial collaboration will be investigated (e.g. licensing of the technology/IPR directly or founding of a technology licensing spin-out) and contacts will be sought. A market analysis will be performed and a commercialisation roadmap and IPR strategy will be created.;149778;149778;ERC-2014-PoC;ERC-POC;AALTO-KORKEAKOULUSAATIO;FI;;; 196427;672013;MAXITHERM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Innovative textile based heating system for technical applications with a special focus on Electric Vehicles;1/05/2015;31/08/2015;;The objective of MAXITHERM is to contribute to the expansion of Electric mobility by extending Electric Vehicles autonomy. We propose a heating system for EV that reduces electricity demand of heating systems in by 30% while maitaining passenger comfort. MAXITHERM is a heating system based on a technical textile composed by a blend of electrically conductive and non-electrically conductive fibres that is integrated within the structure of the vehicles. It provides direct and fast heat to passangers and is 32% more cost efficient that current solutions.;71429;50000;H2020-SMEINST-1-2014;SME-1;MAXITEX GMBH;DE;;; 196388;666412;I-DISC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014;H2020;Development of a Novel, Intelligent Down the Hole Disconnect Tool;1/04/2015;30/11/2017;;"A Bottom hole assembly (BHA) is a series of components that form the lower part of the drill string, extending from the bit to the drill pipe. During oil and gas exploration the BHA can become stuck/jammed due to poor cleaning of the hole and subsequent build-up of cuttings. With direction drilling programmes now exceeding 10km, problems are becoming more common and expensive as oil exploration companies look to access difficult to extract oil reserves from reservoirs which until recently were not commercially viable, particularly in deep water. Methods of disconnecting the BHA need to be activated in highly deviated or horizontal wells where wireline systems cannot easily be employed. In development and exploration drilling, the costs when the BHA becomes stuck down the hole are considerable.

The aim of the I-DISC project is to design, develop and ready for market a high temperature variant of a novel intelligent down the hole disconnect tool (I-DISC) which, in the case of a stuck bottom hole assembly (BHA), would provide disconnection from the BHA and extraction in less than a tenth of the time of the existing state of art methods. Integral to the disconnect feature is a circulation valve (I-CIRC) that enhances the products capability to mitigate becoming stuck in the first place.";3202263,25;2241584;H2020-SMEINST-2-2014;SME-2;CUTTING & WEAR RESISTANT DEVELOPMENTS LIMITED;UK;;; 196410;666794;CoeLux VR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014;H2020;Industrialisation of the CoeLux(VR) product line, through upscaling of the nanodispersion production process, and optimisation of the production chain;1/05/2015;30/04/2017;;"Changing the way we experience the light, bringing the outdoors indoors: this is the mission of the CoeLux technology, which after 12 years of research, managed to obtain CoeLux(HE), the first commercial product able to reproduce sky and sunlight in an interior space. The result is a warm, direct, sunlight and a surrounding sky light, completely transforming indoor spaces, giving them volume and shape through light and shadow, and which allows creating a new relationship between people and the surrounding architecture.
The next step of the companys growth plan is to bring this pioneering product, which can be produced for a small niche of high-end users, to the industrial scale, thus satisfying the blossoming demand. This will be the focus of the CoeLux(VR) innovation project, which will deliver two new modular systems (SkyBlade and SkyCasket), amenable to large scale production.
This will be achieved through 4 developmental stages: 1 Upscaling of the nanomaterial dispersion used to coat the diffusing panel which represents the companys key and proprietary technology. 2. Upgrade of the LED source and the optical design, which allows incorporating a radically new LED system, exclusively designed for CoeLux. 3 Engineering, industrial design and packaging, which focusses around the customers perception of the product, as well as its industrial manufacturing process. 4. Finally, the overarching ambition is to set-up the production supply chain, inspired by lean manufacturing principles, organizing the sourcing of the semi-finished products from the selected suppliers, and the internal production logistics in a standardized manufacturing plan, in view of the high-end positioning of the product.
The project results will allow CoeLux to ramp-up its operational capacity, also increasing the companys preparedness to the global market through core assets as product certification, trademark, and IP protection, thus reaping the benefit of this revolutionising technology.";3113376,25;2179363;H2020-SMEINST-2-2014;SME-2;LIGHT IN LIGHT SRL*;IT;;; 196344;665020;uDAS;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;An Automatic Microfluidic Device Assembly System;1/04/2015;30/09/2016;;"Microfluidic systems, in general, have proven important platforms for biomedical assays. These systems benefit from reduced requirements for expensive reagents, short analysis times, and portability. Although microfluidic systems are convenient platforms, their use in the life sciences is still limited mainly due to the high-level fabrication expertise required for construction.

Integrated microfluidics is one of the most sophisticated three-dimensional (multi layer) solution. It requires soft lithography (PDMS based chips), for production of high complexity microfluidic systems (multiple serial or parallel processes). Integrated microfluidics in particular is almost non-existent in the industry due to the low yield and uncontrolled production process.

My ERC project (MUDLOC-2012) is to develop a microfluidic platform for multidimensional protein array analysis. It uses complex multilayer microfluidic devices that consist of 2 PDMS layers and a glass microarray. The integrated microfluidics system contains thousands of micromechanical valves in micrometer dimensions, controlling thousands of parallel reactions. Our research demands production of hundreds of such devices.

We, as all others who produce integrated microfluidics, suffered from frustrating low yield (15%). In order to improve fabrication yield and to fabricate devices with increased density, we designed and manufactured, a first of its kind, full production process sequence, semi automatic Microfluidic Device Assembly System (DAS). This resulted in a direct increase of device complexity and yield (85%) over the last half year.

The 2nd generation automated DAS prototype will become a generic assembly tool for soft lithography. DAS will enable a critical production standard and process control, which will pave the road for significant penetration of complex integrated microfluidics technology into both academia and industry.";150000;150000;ERC-2014-PoC;ERC-POC;BAR ILAN UNIVERSITY;IL;;; 196384;666278;MobileBattery;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;Mobile Energy System for recharging, energy buffering and long-distance travelling;1/04/2015;31/12/2017;;Objective of the business innovation project is providing market readiness for our Mobile Energy Systems. BVB INNOVATE has developed mobile energy sources in co-operation with Fraunhofer Institutes, universities, and a Swiss mobile platform manufacturer. They are able to deliver clean electric energy to a broad variety of grid, off-grid and mobile applications. Technically, these Mobile Energy Systems are powerful 85 kWh Li-ion batteries on wheels. Mobile batteries can be charged with clean energies from rooftop photovoltaic installations, as well as from wind power or combined heat and power plants or from the grid. Main use-cases are mobile recharging, home and mobile energy storage, and autobahn rental. Fast-charging-network- and roadside-assistance-operators use our systems as mobile fast chargers. E-car drivers or home owners (with a rooftop PV installation) will use our systems for energy buffering and storage. While parked in the home owners garage, the mobile battery will serve the function of intelligent safe back-up power for the home, with additional smart home functionality. For the weekend, the mobile battery can be attached to the owners battery-powered electric vehicle for a long trip. An 85 kWh mobile battery is capable of taking a small electric car up to 600 kilometres. In addition, we will offer mobile batteries for rental at major arterial roads across the country. Owners of e-cars will have the option of renting rather than buying range-extending power packages. The business innovation project will bring a completely new integrated energy storage solution (technology readiness level 7) to the EU and global markets. It will be a game-changer in the field of recharging, energy buffering, and long distance travelling. The business innovation project is a necessary pre-requisite for company growth to 200 m EUR turnover and 380 personnel in 2020.;2847523,75;1993266,63;H2020-SMEINST-2-2014;SME-2;BVB INNOVATE GMBH;DE;;; 196272;663654;HESS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Hybrid Energy Storage System;1/02/2015;31/07/2015;;"The development of solutions with the capability of efficiently managing the energy produced by renewable sources and providing fast response as a back-up system or for frequency regulation is a major need in the energy market. While the former has been traditionally satisfied by using batteries, the latter is mainly covered by fossil fuel dependent technologies. Batteries allow for a significant increase of penetration of stochastic renewable energy sources but are unable to satisfy transient events requiring high power responses. In the case of fossil fuel technologies, a set of well-known drawbacks (high operation costs, fuel dependency, pollution and power supply instability, etc.) shows that these solutions are not the most suitable ones from economic and environmental perspectives.

In order to overcome this situation, Wind Inertia proposes HESS, a hybrid storage solution that integrates in a single system, ultracapacitors (UC) high power density and robustness, Li-ion batteries energy storage density, advanced power electronics and control and management systems. The result is a solution capable of combining and optimizing the use of multiple types of energy resources (renewable, fossil fuel dependent and storage).

The expected outcome of this proposal is the elaboration of a feasibility study and a business plan aiming at verifying the technological, practical and economic viability of the technology describing their most suitable business model, exploitation strategy, etc.";71429;50000;H2020-SMEINST-1-2014;SME-1;WIND INERTIA TECHNOLOGIES S.L;ES;;; 196364;665718;RodBot;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Automated Microhandling System for X-ray Crystallography;1/09/2015;28/02/2017;;"Crystallography is one of the most important methods for studying the 3D structure of complex biological macromolecules. The knowledge of the detailed structure of proteins, enzymes and chromatin allows scientists to understand concepts such as bimolecular interactions, mechanism of enzymatic catalysis and the therapeutic action of drug molecules. A major bottleneck of high-throughput crystallography is harvesting the crystallized form of these molecules from their liquid environments and manipulating them to a location that enables exposure to the X-ray beam. Due of the fragility and large size range of crystals this step has so far been done manually by trained experts.

The proposed research will advance the concept of using a wireless, magnetically driven microrobot, named the RodBot, for micromanipulation of delicate biological entities. The RodBot rolls on a supporting surface in a low Reynolds number fluidic environment and generates rising flows in front of it, and a vortex above it. The flows are utilized for noncontact micromanipulation of fragile objects such as protein crystals. As the RodBot approaches a micro-object, the object comes under the influence of the rising flows which lift it off the substrate. The suspended object is then trapped in the vortex and can be transported to a pre-defined location. The RodBot is powered and controlled by external, low intensity magnetic fields which are generally harmless to living organisms and can readily penetrate most biological material. The flows generated by the RodBot can precisely manipulate crystals of sizes varying from a few microns up to one millimeter. It is capable of separating individual crystals from a group and delivering it to an extraction device called the loop.

The core magnetic manipulation technology for the wireless control of the RodBot has been developed under the auspices of the ERC Advanced grant project BOTMED.";148885;148885;ERC-2014-PoC;ERC-POC;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;CH;;; 196243;663269;SOMA Analytics;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Chronic Stress Biomarkers for Early Detection and Prevention of Burnout;1/12/2014;31/05/2015;;"In 2013, the costs of work-related depression in the EU-27 was estimated to be 617 billion annually , taking in account costs to employers resulting from absenteeism (272 billion), loss of productivity (242 billion), healthcare costs (63 billion) and social welfare costs (39 billion).

The project focuses on the early detection of work-related psychological stress resulting in negative health outcomes, such as burnout or depression.

In phase 1, the project will validate the technical and commercial feasibility of a non-obtrusive smartphone-based solution able to detect stress based on the analysis of speech, sleep and typing behaviour. The project will establish the market interest (competitive analysis, willingness to pay) and recruit corporate organizations willing to participate to clinical trials in phase 2.

In phase 2, the project will implement a clinical trial in order to demonstrate the validity of the existing solution prototype based on the stress biomarkers researched in phase 1. The solution will be tested with adult subjects against other known stress biomarker sensors.

One of the key innovations of the project is the use of speech analysis to evaluate chronic stress by using a dual approach: first, recognize stressed speech using two nonlinear feature models and second, recognize emotion profiles in order to assess mental resilience. The analysis follows a machine learning approach by identifying relevant features to build classifiers which are then trained on a suitable data set.

The platform built in this project will also be used to develop an ecosystem of partner companies (e.g. wearable suppliers, online coaching services) that can reuse SOMA Analytics algorithms inside their own product offerings, thus driving further European innovation in the area.";71429;50000;H2020-SMEINST-1-2014;SME-1;SOMA ANALYTICS UG (HAFTUNGSBESCHRANKT);DE;;; 196350;665589;EMInstr;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Development of a New Wavelength Scanning Interferometer for Embedded Metrology;1/04/2015;31/03/2016;;"The proposed EMInstr project aims to elevate the important research result, a lab prototype of a new wavelength scanning interferometer (NWSI) developed during the ERC-2008-ADG 228117 SURFUND project and to verify its potential as a commercial product. The EMInstr project intends to set up a commercialisation pathway: from verification/validation of the lab prototype, through to technical optimisation, product prototype design, technological licensing and finally into commercialisation. The expected result of this project is to develop a new generation instrument, a pre-production NWSI, for embedded metrology.

The NWSI represents a step-change in manufacturing metrology instruments, being the first of a new generation of micro/nano geometry and surface topography measurement systems. This revolutionary device is the result of integrating several advanced technologies, wavelength/frequency scanning, GPU electronics and a multi-interferometry configuration, to produce the NWSI with unique capabilities in high-speed, large-measurement ratio (range/resolution) and robustness.";149662;149662;ERC-2014-PoC;ERC-POC;THE UNIVERSITY OF HUDDERSFIELD;UK;;; 196395;666496;MIIMETIQ;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Telemetry and Telecontrol for the Internet of things (IoT);1/04/2015;31/10/2017;;"Machine-to-machine (M2M) is a broad label that can be used to describe any technology that enables networked devices to exchange information and perform actions without the manual assistance of humans. M2M communication is often used for remote monitoring. In product restocking, for example, a vending machine can message the distributor when a particular item is running low. M2M communication is an important aspect of warehouse management, remote control, robotics, traffic control, logistic services, supply chain management, fleet management and telemedicine. It forms the basis for a concept known as the Internet of Things (IoT).

The market for M2M will be the fastest growing segment of the IT industry from now until 2017. The M2M market, including technologies related to the Internet of Things, will grow from $44.0 billion in 2011 to $290 billion in 2017.

M2M Cloud Factory is a private white label supplier to major manufacturers and system integrators of a M2M / IoT application development framework based on a cloud solution called MIIMETIQ. MIIMETIQ is the most flexible, powerful and scalable M2M development framework in the IoT market. MIIMETIQ provides the highest levels of scalability and security as well as a set of powerful tools on which our customers can quickly build and deliver custom M2M / IoT applications for the most demanding requirements and integrate data into customer key enterprise applications and systems.

We have identified two disruptive improvements for our current framework, to both simplify and accelerate the development of M2M and IoT applications which will secure the continuous growth of the company not only on the EU level, but globally.";1431400;1001630;H2020-SMEINST-2-2014;SME-2;NEXIONA CONNECTOCRATS SL;ES;;; 196413;666841;HEALEX;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;HEALEX High Efficiency Air Liquid Heat ExchangerAn innovative, new heat exchanger that improves energy efficiency in cooling and ventilation systems;1/04/2015;31/12/2017;;"HEALEX (High Efficiency Air to Liquid Heat Exchanger) has the potential to reduce electricity consumption by 30% in several cooling applications. This tremendous energy savings and corresponding CO2-emission reductions can be achieved by a strikingly simple innovation: the improvement of a single system component, the heat exchanger.
The HEALEX project aims to replace the state of the art heat exchanger in certain existing products within the cooling sector for a novel, simple, conceptually unique and much more efficient heat exchanger: HEALEX.
The objectives of this project focus on solving the technical and commercial bottlenecks identified during Phase 1 of the project. These are: i) Achievement of HEALEX mechanical strength required to gain market acceptance, ii) Fully develop three different HEALEX types, iii) Securing future HEALEX customers, and iv) Assuring a competitive product.
HEALEX project will be carried out by Airec, a Swedish SME which has since its foundation focused on developing, producing and marketing different types of heat exchangers.
Airecs commercialization strategy is based on a business to business relationship, where HEALEX customers and their R&D departments are involved at an early stage of the HEALEX project in order to meet their individual requirements. This supports a more efficient development process and a quicker market introduction and expansion. All in all, the planned commercialization strategy focuses on giving Airecs customers strong reasons to shift to HEALEX.
Scientists and market experts have expressed HEALEXs potential to create the largest paradigm change in the cooling industry for several decades. By successful completion of the project objectives, HEALEX will become a reliable and profitable product contributing to both Airecs growth and to reducing the electricity consumption and carbon footprint of European industries, thus helping to achieving the goals within EUs Energy and Climate targets for 2020.";1470776,5;1029543,55;H2020-SMEINST-2-2014;SME-2;AIREC AB;SE;;; 196336;664714;ServoTec;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Fast Data Acquisition and Servo Technologies;1/05/2015;31/10/2016;;"Fast data acquisition devices and servo technologies are essential in multiple processes that require a fast response to a sensor input. They are present in multiple automatic procedures for the accurate functioning of trains, planes, and robotic systems either for domestic or industrial activities. As a result of the research performed in the SM-DNA-Repair project (ERC-206117), we have developed a fully digital acquisition board superior in most specifications to current technology because it combines, in a single board, high speed, high channels count, easy integration and development, and is cost effective. The new board has already been validated in a relevant Atomic Force Microscopy (AFM) environment (TRL5, Technology Readiness Level 5), being able to reproduce results obtained with analogue devices. Now, I aim to turn the output of the SM-DNA-Repair project into a commercial proposition by exploring the commercial potential of the device and by eventually attract capital for its further development.

The ServoTec Proof of Concept project aims are three-fold. First, to perform a market feasibility study of the fast digital servo board developed, in order to exploit the technology integrated into AFM commercial systems for high-speed applications. Second, to make commercially available the technology and to explore other added-value services for wide range applications and customised solutions. Third, to establish the IP position strategy, including the possibility to license the technology to a company that already commercialises data acquisition boards for the general market. These three commercialisation formats will address a global market. Exploratory work regarding competitive analysis, IPR position and strategy and contacts with the industrial sector has been already initiated. The commercial exploitation route, to be defined along the project, will be either through a spin-off or SME, through patent license or agreement for technology exploitation.";149897,5;149897,5;ERC-2014-PoC;ERC-POC;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 196380;666148;DSTB;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Dyadic Secures The Breach;1/04/2015;31/03/2017;;"Over the last years, the world has seen an unprecedented escalation in the number and size of data breaches. In 2013, a total of 550 million identities were breached; a 62% increase over 2012. In addition, the cost of breaches is rising, with a worldwide average of over $3 million per breach. Hacking is the primary causes of data breaches, and todays existing solutions are simply not sufficient to meet the threat.

The objective of Dyadic Security is to provide high security to organizations, and to protect digital assets, even in the event of a network breach. Dyadics Distributed Security Module (DSM) is a unique software-only offering that provides the highest level of security while being affordable and easy to deploy. At the core of the DSM lies cutting-edge technology based on decades of cryptographic research on secure multiparty computation (MPC). Dyadics DSM solves the inherent single point of failure in all of todays security systems. Strong cryptographic solutions exist for protecting data, securing web traffic, authenticating users, and so on. However, they all rely on the secret key and authentication credentials (e.g., passwords) remaining secret. In todays reality where hackers get past firewalls and penetrate deep into networks, these keys and credentials are stolen thereby rendering all cryptographic protection useless. Dyadics DSM randomly splits keys and credentials across servers so that they are never in any single place to be stolen. The advanced protocols used in the DSM ensure that even if some of the servers are breached and completely controlled by an attacker, the secrets and credentials cannot be stolen. The result is that digital assets remain safe, even when all else has failed and attackers are inside the network.

Dyadic has a disruptive and innovative product range which, in contrast to existing solutions, provides protection in the event of a breach, and not just detection.";2882500;2017750;H2020-SMEINST-2-2014;SME-2;DYADIC SECURITY LTD;IL;;; 196412;666815;ICE Cubes;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-2;H2020;ICE Cubes Service - International Commercial Experiment Cubes Service;1/06/2015;31/05/2017;;"The International Commercial Experiment Cubes Service (ICE Cubes) will provide rapid, simplified, low cost access to the International Space Station, creating the opportunity to maximise the use of the remaining lifetime of the ISS. The initial service will enable any organisation, public or private entity or individual, such as universities, academic programmes and pharmaceutical companies/research centres or private persons to perform experiments on the ISS. Furthermore the ICE Cubes service will develop special miniaturised capabilities for use in space that do not exist today, in response to market needs.
Space Applications knowledge gained from working on a daily basis with ESA to establish scientists needs, to train astronauts, and to develop and operate payloads on the ISS will be used to realise this commercial opportunity.
ICE Cubes fully supports the process of experiment development and takes care of the flight acceptance, launch manifest and operation of the customers experiments. The ICE Cubes service includes:
As much or as little customer support as needed, throughout the process of experiment development, flight acceptance, launch and operation of the experiments;
The ICE Cubes on-orbit facility consisting of (1) a Framework facility for plug-and-play modular Experiment Cubes and (2) the PharmaLab, a novel multi-cube facility for pharmaceutical research;
An out of the box installable ground monitoring and control software to access experiments;
Market driven development of additional added value miniaturised equipment and facilities.
This project will result in the set up and operation of the ICE Cube service, including the design and development of the ICE Cubes system, the launch of the Framework facility, the PharmaLab facility and at least one Experiment Cube developed by a university and their on-orbit and on-ground operation, as well as the initiation of an entrepreneurial ecology of supporting technology development companies.";3338750;2337125;H2020-SMEINST-2-2014;SME-2;SPACE APPLICATIONS SERVICES NV;BE;;; 196310;664174;GOLFTRACKER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Automatic tracking of golf games for improvement and training purposes, using GNSS receivers, wearable sensors and Earth Observation information;1/03/2015;31/08/2015;;"The overall objective of GOLFTRACKER is to offer golfers a product to automatically track of golf shots during the game, collecting and combining data from GNSS receivers, wearable motion sensors and Earth Observation mapping.

The resulting product, will be based on a general wearable device implemented on top of existing COTS hardware (e.g. Samsung GEAR, Apple Watch) and a specific tracking device for golfing using a sensor fusion approach. The product will allow golfers to improve their game, providing statistics for post analysis, peer benchmarking tools and training recommendations. The proposed innovation is aimed at equipment segment and training segment (golf lessons) with estimated revenues of 3300 Million euros in Europe.

This phase1 project focus on exploring the business opportunity related to the automatic tracking, by developing a innovation strategy supported EGNOS/Galileo and Sentinels that will lead to patent registration. The activity aims also to assure users involvement, collecting the feedback from early adopters and promote the product's features to reach a wider community. A business survey will be performed, consolidating the results on the product business plan.

The work to be performed is led by BLUECOVER with the participation of third-parties.";71429;50000;H2020-SMEINST-1-2014;SME-1;BLUECOVER TECHNOLOGIES, LDA;PT;;; 196300;664018;NO_MORE_FEAR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;A NOvel FFR Measurement fOR accurate dEtermination of stenosis Functional severity in ischemic hEARt disease;1/01/2015;31/05/2015;;"Medis medical imaging systems BV (MEDIS), with 25 years of experience in medical imaging, will introduce a novel imaging-based biomarker as an accurate proxy for functional stenosis severity, creating a breakthrough in the treatment of ischemic heart disease (IHD). This non-invasive imaging algorithm should replace the current standard of using a vascular pressure wire to measure the Fractional Flow Reserve (FFR) - a measure for the physiologic significance of a coronary obstruction on the basis of which the interventional cardiologist decides whether an obstruction needs to be treated with stent placement, or otherwise should be left untreated.

Using pressure-wire FFR is risky, time consuming, costly, associated with additional X-ray radiation, not always accurate and not applicable in highly curved arteries. MEDIS has developed a functional prototype of its imaging algorithm (FFRQCA) that accurately calculates the FFR from readily available 2D X-ray images through 3D reconstruction, advanced image processing algorithms and computational fluid dynamics. In a direct comparison with the current standard, this novel approach showed excellent diagnostic accuracy of 88%. Efforts to further optimise the technology are currently ongoing: a multi-centre investigator-driven trial is being carried out across 2 European countries, the US and China.

In this Stage 1 SME Instrument project, MEDIS will investigate the commercial feasibility of this innovation that has already sparked enthusiasm amongst interventional cardiologists worldwide.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEDIS MEDICAL IMAGING SYSTEMS BV;NL;;; 196369;665775;2-NanoSi;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Ratiometric FRET Based Nanosensors for Trypsin Related Human Recessive Diseases;1/04/2015;30/09/2016;;"The project aims to create a demo system for cost effective, non-invasive device for rapid detection of cystic fibrosis in humans.
The detection of human recessive diseases has been dominated by the use of fluorescent biomarkers, based on organic dyes, helping researchers to study and analyse gene expression, cell cycle, and enzymatic activity. Among several proteolytic enzymes, trypsin has attracted much attention, as it is a target in the study of various important human recessive diseases including, for example, cystic fibrosis (CF).
We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometric determination of cystic in humans. Current detection technologies for cystic fibrosis diagnosis are slow, costly and suffer from false positives. The 2nanoSi proved to be a fast (minutes), a single-step and with two times higher sensitivity than the state-of-the-art biomarkers based sensors for cystic fibrosis, allowing the quantification of trypsin concentrations in a wide range (25-350 ?g/L). Moreover, our approach can be used from the 4th day of life when the trypsin concentration is already the same as in adults. Furthermore, as trypsin is directly related to the development of cystic fibrosis (CF), different human phenotypes, i.e. normal (160-340 ?g/L), CF homozygotic (0-90 ?g/L), and CF heterozygotic (91-349 ?g/L), respectively, can be determined using our 2nanoSi nanospheres. We anticipate the 2nanoSi system to be a starting point for non-invasive, easy-to-use and cost effective ratiometric fluorescence biomarker for recessive genetic diseases alike human cystic fibrosis.";150000;150000;ERC-2014-PoC;ERC-POC;FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA;ES;CORPORACIO SANITARIA PARC TAULI DE SABADELL;ES; 196349;665482;MIMO;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;A commercial device for mercury isotope monitoring (MIMO);1/05/2015;31/10/2016;;Mercury (Hg) is a toxic element with adverse effects on humans and wildlife. Cross-border export of atmospheric Hg emissions makes Hg a global pollutant. In 2013 the UNEP Minamata Convention on Mercury was signed by over 100 countries and aims to reduce future Hg emissions. Implementation of environmental Hg policy requires environmental monitoring efforts. Hg monitoring networks such as GMOS and AMNet typically gather data on atmospheric Hg concentrations, but do not provide information on the Hg emission source. In the ERC StG MERCURY ISOTOPES we have developed dual Hg isotope signatures as fingerprints for Hg sources and transformations. Our observations suggest that most, but not all, anthropogenic Hg emission sources are isotopically distinguishable. The goal of the ERC POC MIMO project is to develop, together with Tekran Inc., the largest global Hg instrument developer, a commercial Mercury Isotope MOnitor (MIMO) that is compatible with current Hg monitoring equipement and programs. Successful development of the MIMO will generate (a) patent(s), drive sales of MIMO and consumables, opens up worldwide opportunities for environmental monitoring companies, and addresses a globally important societal issue.;150000;150000;ERC-2014-PoC;ERC-POC;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196257;663486;HELIUM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;High European Laboratory for Institutes, Universities and Markets;1/03/2015;31/07/2015;;"HELIUM's overall innovation project aims at designing and developing a commercial crewed near-space balloon-borne laboratory platform. This solution will be a bridge between ground and in-orbit testing allowing users to access space-like conditions and validating new technologies.
HELIUM will be led by Zero2infinity, an experienced SME that develops, tests and operates near-space vehicles based on high-altitude helium balloons; and the only private company in Europe with the capability to perform unmanned heavy near-space balloon flights.
The results of the HELIUM project will offer European space companies, researchers and scientists a platform to access space-like conditions, with more flight opportunities and at lower costs to test, validate, demonstrate and calibrate technologies, equipment and new concepts to increase their TRL, boosting up the competitiveness, non-dependence and innovation of the European space sector.
The specific objectives of the current phase 1 are to study and evaluate the technical viability as well as the sustainability and profitability of the HELIUM solution. The objective of the overall innovation is that the current stage of HELIUMs TRL6 prototype version reaches a TRL9 commercial level at the end of phase 2.
HELIUM's platform offers several advantages compared to other test infrastructures: space-like integrated environment, long exposures, low mechanical requirements, adaptability of the platform to the experiment and cost-effectiveness. The system will perform flights to altitudes up to 40km, adjustable from a few minutes to several hours or even days.
Zero2infinity has extensive experience in developing, testing and integrating pressurized capsules and flying them on near-space balloons. This background and knowhow enables the company to significantly reduce the risk of undertaking the HELIUM project while maximizing the probability of success of this business opportunity.";71429;50000;H2020-SMEINST-1-2014;SME-1;ZERO 2 INFINITY SL;ES;;; 196301;664044;OP3C;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;On board Processing for Compression and Clouds Classification in hyperspectral data;1/01/2015;30/06/2015;;"The objective of the overall innovation project is to industrialize a Field Programmable Gate Array (FPGA), which will be installed, on board of satellites carrying hyperspectral sensors and will be capable of
a) Compressing the acquisitions with a 12-22 ratio and
b) Classifying the cloud cover of these acquisitions
The result of the proposed FPGA will be the compressed acquisitions, the cloud coverage mask and a compression structure for direct processing without decompression. The FPGA will provide this way to the operator of the satellite hyperspectral sensor, the ability to optimize the down streaming procedure, on one hand by selecting the proper images to download (in terms of cloud cover) and on the other hand by downloading 12-22 times less data (as a result of the compression elaboration). The above will lead to significant gains in efficiency such as i) lower volume of transmitted images (only the useful ones, in terms of cloud cover), ii.) less need for storage on-board and flexible acquisition planning, iii.) reduced hardware requirements.
The main users are Space Agencies, Satellite Operating Centers, Satellite manufacturers, Hyperspectral sensor manufacturers and Consulting companies for satellite mission planning.
The OP3C project aims to study the feasibility of the above mentioned concept in a niche market where there is hardly any completion. The goal of the OP3C project is to study the technologic (user constraints/needs, time needed to have the product ready) and economic viability (market analysis, human resources, capital, infrastructure cost, etc) of the proposed concept to the corresponding industries. The target is to examine how the product can reach TRL9 from the TRL6, which is currently at. Compiling a successful feasibility study, the OP3C project intends to submit for the phase 2 funding in order to implement the derived business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;PLANETEK HELLAS ETAIREIA PERIORISMENIS EFTHYNIS YPIRESIES CHARTOGRAFISIS MESO DORYFOROU;EL;;; 196312;664205;eco-railjacket;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Total Full Ecologic Embedded Railways Jacket System;1/02/2015;31/05/2015;;"The Total Full Embedded Railways Jacket System: this new embedded railways jacket system designed by Prefarails is used to reduce the vibration of the vehicles, minimize the road and housing noise and vibrations around the tramways or trains, improve the passengers comfort and minimize the environment impacts.
In addition to the above characteristics, the system also offers the following main advantages:
* Better electrical insulation of rails
* High temperature resistance
* Short construction time
* Long product and concrete trackbed lifecycle
* Less soil preparation and installation time
* Direct and indirect economic benefits
* Waterproof system
The improvement of the electrical insulation will allow Prefarails to develop its activities in the railways system with the signaling done by measuring rails insulation.
The support provided for this Phase I of the project will allow the company to perform the following:
* realization of the market analysis
* development of the marketing plan
* elaboration of the business plan
The support foreseen at the Phase II of the project will help the company to perform the following:
* acquire the necessary equipments and services for the industrialization phase
* customize the module to achieve the dimensions required by some customers (SNCF- France, SNCB - Belgium, Eitihad Rail - Saoudi Arabia, oman Railways) for the pilot test phase
* support the market development
Several railways networks operators are looking for this solution, especially for the realization of the prefabricated railways made with the Prefarails' technology, which has a much higher life duration, is maintenance free and is cheaper than the existing solutions.";71429;50000;H2020-SMEINST-1-2014;SME-1;C.A.S.Q.C. PREFARAILS;BE;;; 196366;665630;ADAPTIVE;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Industrial implementation of adaptive computational methods for turbulent flow and fluid-structure interaction;1/04/2015;30/09/2016;;"The ERC StG project UNICON (Project ID 202984) was completed in July 2013. The goal of UNICON was to develop new adaptive finite element methods for computer simulation of fluid-structure interaction, in particular for problems involving turbulent flow. Simulation of turbulent flow is an outstanding computational challenge, where the UNICON project made significant progress beyond the state of the art. The scientific results of the UNICON project include a new theoretical and methodological framework, and a computer implementation of the methods as open source software, published as part of the FEniCS project, co-founded by the PI (Hoffman) in 2003. FEniCS is today a world leading open source software for computer simulation based on differential equations, with an estimated 50 000 downloads per year, and the PI today leads the PRACE Tier-0 project FEniCS-HPC, in which algorithms and software are developed for the most powerful supercomputers in Europe. Compared to competing simulation software, free as well as commercial, UNICON computational technology has proven to exhibit unique features with respect to accuracy and efficiency.

The idea of this ERC PoC project is to commercialize the UNICON simulation technology. In particular, ADAPTIVE targets civil (non-military) industry, with a focus on subsonic fluid dynamics. The strategy is to deliver services and products tailored to each customer, from deliverance of a simulation result, to education and support for integration of the simulation tools in the workflow of a customer.";146897;146897;ERC-2014-PoC;ERC-POC;KUNGLIGA TEKNISKA HOEGSKOLAN;SE;;; 196228;663090;Bacticon1;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;BACTerial detection and CONtrol of urinary tract infection;1/03/2015;30/04/2015;;"Problem
Approx. 50% of all patients with severe blood stream infections die from the infections, while the remaining 50% incur excessive socio-economic expenses from prolonged hospital stays. In fact, the fourth largest cause of death in the western world is hospital and care acquired infections, most often caused by urinary catheters. Present state-of-the-art, measuring the temperature of a patient, indicates if the patient has an infection, but with approx. 2-3 days delay, and with many possibilities for false positives (increasing temperature can mean other things than infection).

Solution
The innovation, the Bacticon Catheter, is a catheter impregnation technology based on a new biosensor/biomarker principle based on biomarkers, bio-nanoparticles and nano-channels in a new hybrid material, allowing for an immediate detection. The system is an add-on to existing catheters and is therefore cost efficient and face a faster route through approval procedures, providing much more precise and real-time monitoring.

Project
The project has three objectives:
1: Technological feasibility study: Verify and adjust an integrated prototype
2: User feasibility study: Verify the product need by conducting a market and user study, a product innovation strategy, partner search, feasibility of concept, benchmarking with other products and a go-to-market strategy.
3: Economical feasibility study: Analyse the economical sustainability of the product

Business model
The innovation is well suited to be commercialised through the sales and marketing channels of a med-tech company, which is already established in the market place, and where the Bacticon Catheter can be integrated in the existing product portfolio of such med-tech company. BioModics is pursuing this option as priority one.

Market
The dominating markets are the American market with a 547 M urological catheter revenue and Europe with 615 M. Increasing growth rates are expected, especially in Asia, Europe and US.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOMODICS APS;DK;;; 196285;663824;MalaDiag;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Development of a very rapid diagnostic test for malaria, based on break-through detection technology and new biomarkers of infection.;1/12/2014;31/05/2015;;"The overall project objective is to develop and bring to market a very rapid diagnostic test (V-RDT) for malaria, based on break-through detection technology and particularly relevant biomarkers of infection.

Our ambition is for our diagnostic device to become the reference technology in all malaria endemic areas.

A key advantage of our approach lies in the combination of an innovative detection device with novel biomarkers that should significantly improve the quality of testing and the ability to implement mass testing campaigns.

Our device is expected to overcome most shortcomings identified in devices currently on the market. The expected added value of our proposed diagnostic device to users is multiple including:
Rapidity: 1 minute vs. 15-20 minutes required for most current tests. This is a major competitive advantage for cross-sectional testing necessary for eradication efforts;
High sensitivity including quantitative evaluations (picomolar detection);
Several simultaneous measures to distinguish parasite species (P. falciparum / P. vivax);
Infection parameters (parasite density and antibody response): the comprehensive nature of our diagnostic read-outs provide information on prognosis and/or therapeutic response in addition to simple yes/no diagnoses; and
Functional and reliable in expected field conditions (tropical environments).";71429;50000;H2020-SMEINST-1-2014;SME-1;VAXIMAX;FR;METEMIS DEVELOPMENT;FR; 196354;665317;Diricore;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Exploiting vulnerabilities in protein synthesis for cancer diagnosis and therapy;1/05/2015;31/10/2016;;"Tumor growth requires continuous synthesis of proteins, nucleic acids and lipids that are important components of the cell. Demand for amino acids as the building blocks for protein synthesis in rapidly dividing tumor cells is often much higher than that of normal cells. Such increased demand can represent a vulnerability of the tumor. Importantly, this vulnerability is already being exploited for therapy in one instance: Addition of L-asparginase - an enzyme lowering the concentration of the amino acid asparagine in blood - to chemotherapy against acute lymphoblastic leukemia, resulted in a dramatic increase in cure from 5% to 95% of patients treated. Recent scientific publications highlight the fact that tumors are often metabolically rewired, and multiple examples of altered amino acid demand and/or turnover have been demonstrated in different cancer indications. Multiple drugs are under development that target amino acid availability, uptake or biosynthesis.

The challenge is to identify the potential sensitivity of individual tumors to such drugs.

Recently, we developed diricore, a procedure for determination of restrictions in the availability of particular amino acids for protein synthesis. To demonstrate the potential for diricores diagnosis capability in cancer, revealing proline limitations for protein synthesis in kidney cancer. We also used kidney cancer cell lines to verify sensitivity to proline deprivation, suggesting therapeutic possibilities.

We propose here to develop diricore towards a commercial diagnostic platform for determining limiting amino acid availability profiles in cancer patients. This information will guide physicians in taking dietary measures or prescribing drugs that inhibit amino acid uptake or biosynthesis.";149500;149500;ERC-2014-PoC;ERC-POC;Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek ziekenhuis;NL;;; 196398;666534;PCT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Plant CT - Making Plants Healthier;1/04/2015;30/09/2017;;"Producing the highest quality crop with a maximized yield requires the real-time measurement and actionable analysis of a large number of plant-related external factors. These factors are meteorological, geological, organic and human-related. Measuring and processing these parameters is at the core of any decision-support system intending to streamline the production of farmlands. Currently there are no solutions available that can quantify all on-site plant-related parameters in real-time. By doing so it could stop superfluous use of expensive and environmentally harmful chemical agents while reducing yield loss, saving European farmers billions.

We intend to deliver and commercialize a Plant CT solution that allows remote diagnostics of plants, on-site monitoring and comprehensive decision support. We understand a Plant CT to be a network of compact measuring devices on cultivated areas, which arms agricultural producers with precise, individualized data and recommendations. By deploying devices at several locations, it is possible to quantify agronomically important factors and to precisely determine the exact plant disease risk (and other important metrics, such as irrigation) at any particular location on a farmland.
By the end of this project we aim to be ready to commercialize a system of small, easily installable, compact and inexpensive precision sensors delivering easy-to-understand actionable information including highly reliable automated diagnostics (with spore and mite detection). Following its commercialization we will be positioned to collect qualitatively and quantitatively unrivaled data, leading to further opportunities in creating an ultimate agriculture intelligence service.

Due to our long-time involvement in precision viticulture, we have experience in providing wine / grape producers with information on weather parameters and diseases in a clear manner, helping farmers to optimize their agricultural procedures.";1462444;1023710;H2020-SMEINST-2-2014;SME-2;QUANTISLABS INFORMATIKAI BIZTONSAGTECHNIKAI KUTATOLABORATORIUM KFT;HU;;; 196295;663953;TidalHealth;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Health Condition Monitoring of Small Scale Tidal Generators Using Miniature Torque Sensors;1/03/2015;31/08/2015;;"By 2050, the size of wave and tidal energy is expected to reach an installed capacity of 100GW, which will be able to power 66 million European homes and also enable the EU to meet its target of reducing emission of green-house gases by 80-95% below 1990 levels.

Tidal generators are installed in very harsh environments of the sea-bed, where saline water, unpredictable tidal flow, marine debris and suspended particle impact can cause serious damage to generator blades and gearboxes. In addition, the unpredictable changing nature of load demand causes stresses on the tidal components.

The primary objective of the TidalHealth project is to commercially produce a direct torque measurement device attached to tidal generator shaft for overall condition monitoring of tidal power plants remotely. This will result in the reduction of operations and maintenance cost of the plants and thus improves the return on investment for tidal technologies.";71429;50000;H2020-SMEINST-1-2014;SME-1;PARS MAKINA SANAYI VE TICARET LIMITED SIRKETI;TR;TRANSENSE TECHNOLOGIES PLC;UK; 196286;663828;AQUASONIC-diesel;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;UPSCALE OF ELECTRICAL PULSES TECHNOLOGY CAPABLE OF FRAGMENTING HYDROCARBON CHAINS IN FUEL FOR MARITIME APPLICATIONS;1/02/2015;30/06/2015;;"Marine fuels used in ships are considered of the lowest grade as far as the quality is concerned. Massive engines of the ships consume thousands of litres of fuel each day. Fuel cost is one of the most important factors which shipping companies consider while predicting profits. To achieve maximum profit and to reduce pollution from ships, it is extremely important for the propulsion engines to burn fuel oil efficiently. Current actual solutions on the market to improve the combustion of fuel in engines are mainly chemical surfactants/dispersants used as additives with the purpose to homogenize the fuel. The AQUASONIC-diesel solution offers an environmentally friendly alternative in order to improve the combustion process of fuel before combustion by applying electric pulsed power technology to offer the following benefits:
Lowering fuel consumption by 20%, dropping emissions by up to 60% leading to cost savings.
Foreseen for new builds and retrofit without causing any modifications to the marine diesel engines.
Maintenance free, robust, natural and ecological physical treatment of fuel that does not affect the fuel properties, without the application of chemicals (unlike the state of the art).
Selling price between 2.000-20.000 depending of the fuel flow.
Being Spanish market leaders in in electric pulsed power technology, our company Aquasonic has developed and tested this system on a small scale. Through this project we wish to upscale our successfully tested system, certify it according to maritime standards and take advantage of the huge market opportunity.";71429;50000;H2020-SMEINST-1-2014;SME-1;AQUASONIC SL;ES;;; 196383;666257;Eciwind;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014;H2020;Cost effective wind turbine of 40 kW of rated capacity;1/05/2015;31/10/2017;;The project arises from a joint venture between Enair Energy SL and Lancor 2000 S Coop to develop a Cost efficient Small Wind Turbine (SWT) of 40 kW rated capacity (ECIWIND).Within the wind energy sector, the small wind power is growing: According to World Wind Energy Association the small wind power market is expected to increase massively, from 768 M in 2013 to 2517 M by 2020, at a CAGR of 22%.The main challenge of the small wind energy industry is to decrease its costs to push a socialisation of this renewable technology. Thus, this electricity generation will be more competitive in the energy market and independent of the subsidies. The European Commision highliths the importance of Small and Medium Enterprises (SMEs) as small energy producers and the need to empower them to take up this role. Several european SMEs such as farms (200-400 kWh/day) and small industry (200- 450 kWh/day). In the case that these end users are located in areas where annual average wind velocity is higher than 5 m/s, small wind turbines in the 10-50 kW capacity is the best option to cover their energy needs. The acquisition and commissioning costs of SWT in this capacity range rounds 4000 /kWh and have annual maintenance average costs of 1500 /year depending on the configuration, which makes unaffordable the investment without government subsidies. The price reduction on this capacity range can be approached through the elimination of costly parts of current technologies as the Gearbox, and the optimization of the cost/performance of the rest of components.Enair and Lancor have therefore identified a business opportunity for SWT technologies and have developed a first prototype of ECIWIND at 10 kW scale (free-gearbox with pitch control and permanent magnet generator SWT) that requires 50% less maintenance and decrease the price to end user installed in 40%, which entails an investment payback period <6 years without any government subsidy.;1867578,75;1307305;H2020-SMEINST-2-2014;SME-2;ENAIR ENERGY SL;ES;LANCOR 2000 S COOP;ES; 196280;663768;ENBIOSURF;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Enzymatic production of a novel class of nonionic, mild and biobased surfactants;1/03/2015;31/10/2015;;A completely new class of non-ionic, biobased and mild surfactants that have been shown to have a number of advantageous technical features compared with commercial alternatives, have been produced using a novel enzymatically catalysed process (patent pending). This project aims at investigating the feasibility of a more economical route of their production to expand their market potential. The novel group of surfactants consist of oligomeric alkyl glycosides with head-groups substantially larger than those already on the market. The biocatalytic process developed is the only way such surfactants can be produced, and they have for the first time ever been produced in amounts that have allowed for their features to be established. Their mild and technically superior features render them extremely attractive for replacing ethoxylated surfactants such as the polysorbates in pharmaceutical formulations, thereby solving the problems of allergies and side-effects associated with the formation of oxidation products including formaldehyde. The new class of surfactants will, if the production cost is reduced, also be very attractive for the cosmetics- and personal care markets including a large number of European cosmetics companies. The cosmetic sector has a large need for both replacing ethoxylated surfactants and introducing green ingredients that can be accepted under for instance the Cosmos standard, a European standard for organic and natural cosmetics. The mild and green features of the oligomeric alkyl glycosides make them very attractive for this sector. This project aims at investigating the bottle-necks for achieving a more economical process including type of raw material, re-use of material, conversion, downstream processing etc. This will prepare for scaling up and a larger market introduction which will be the aim for a project proposal for phase 2 funding, after which a partner deal including licensing and/or acquisition is expected.;71429;50000;H2020-SMEINST-1-2014;SME-1;Enza Biotech AB;SE;;; 196373;665992;MSCA FIRE;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-DP;H2020;MSCA FIRE: Fellows with Industrial Research Enhancement;28/09/2015;27/09/2020;;"MSCA FIRE: Fellows with Industrial Research Enhancement

The FIRE programme is an integrated 4 year Doctoral Training programme, bringing together two national Centres for Doctoral Training: the Centre for Sustainable Chemical Technologies and the Centre for Digital Entertainment.
The objectives of MSCA FIRE are to increase the international aspects of these successful intersectoral and inter-disciplinary programmes and to develop the elements of transnational mobility and career development, common to our industry facing doctoral programmes.
Objectives are to:
- Offer FIRE Fellows the benefits of two established national Doctoral Training Centres, as they expand their international company placement activities.
- Bring Fellows the benefits of the cross-sectoral reach of both Centre, with vibrant industries.
- Enhance interdisciplinarity and offer added-value training practices beyond their specialised research area, to all fellows.
- Use these synergies to fire-up the fellows to become autonomous, creative, highly-skilled and fully ready for careers in international industries.
This will be achieved by:
- Implementing a combined 4 year doctoral training programme,
- using two existing national Doctoral Training Centres and their already engaged industrial partners.
MSCA FIRE will deliver:
- 20 autonomous, creative, highly-skilled scientists and engineers fully ready for careers in international industries, and
- A model for intersectoral, interdisciplinary doctoral training in an international environment.
Industrial partners ensure that research carried out is relevant and will enhance employability of graduates, both in Europe and globally.";4185600;2092800;H2020-MSCA-COFUND-2014;MSCA-COFUND-DP;UNIVERSITY OF BATH;UK;;; 196297;663984;SMARTER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Surveillance of Maritime Surroundings through Laser Technology;1/02/2015;31/07/2015;;Sensor technologies used today onboard maritime assets provide incomplete surveillance of the surface layer. A prototype Ladar sensor has been developed in recent previous projects that has been demonstrated to be able to properly survey and monitor the surface layer surroundings of vessels, platforms and coastal infrastructures. It represents an unique heterologation of system technologies and features. This enables enhanced safety, security, environmental monitoring and reduced operational risks. The ownership of the sensor prototypes (and its related IPR) has been spun-off to a separate entity (named Ladar Ltd) a subsidiary of G.M.S. Global Maritime Services Ltd that now is about developing the business case and commercialization process. This project will focus on the critical decisions that need to be taken at this stage to maximize the value of the Ladar in the maritime market domain. It will analyze the market in relation to the plurality of Ladar applications, purchase power/pricing, dissemination/marketing, production escalation, distribution and various after-sales services. In the traditional shipping market the Ladar Ltd business case will follow a disruptive business plan disrupting the traditional vendor based sales offering with a sensor solution congruent to the most advanced of the 'user driven mind' concepts and directly fitting with user/client needs.;71429;50000;H2020-SMEINST-1-2014;SME-1;G.M.S. GLOBAL MARITIME SERVICES LIMITED;UK;;; 196242;663262;FlexiHyLift;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;A flexible hybrid forklift that utilizes advanced power technology and electronics to offer high performance and efficiency in both indoor and outdoor applications for the logistics industry.;1/03/2015;31/08/2015;;"FForklifts are crucial to running efficient and effective manufacturing and warehousing plants. Initially, counterbalance forklifts were fitted with internal combustion (IC) engines using diesel or LPG. However these emit polluting and hazardous gases and are unsuitable for indoor use. Electric forklifts produce zero emissions during use and are noiseless, permitting indoor application but also have shortcomings as they are not ideal for outside use and so operators require different forklifts for indoor and outdoor use, with forklifts costing from 25,000 to 90,000.

Nexen Transport have developed a novel hybrid counterbalance forklift truck using both an IC engine and electric power to deliver excellent performance in both indoor and outdoor use for large logistic entities with both indoor and outdoor operations such as freight, logistics, retail and wholesale companies. FlexiHyLift will deliver a new range of intelligent, environmentally friendly, highly efficient, versatile and cost effective counterbalance forklift trucks with benefits including:
Light, modular power pack with a lithium ion battery with super capacitor capability and is re-chargeable through the hydraulic system of the forklift.
Can be switched from IC power to battery power during indoor and outdoor use respectively.
High-energy efficiency and cost effectiveness owing to the novel modular, hybrid power pack. The power pack recovers energy during the IC engine operation through a small, highly efficient IC range extender engine.

During Phase 1 we will conduct a market usage analysis with companies that have both indoor and outdoor operations to determine the specific industry requirements so as to produce an optimal solution.

In Phase 2 we intend to fully integrate the IC engine and electric power system together resulting in a fully operational hybrid forklift.";71429;50000;H2020-SMEINST-1-2014;SME-1;NEXEN LIFT TRUCKS LIMITED;UK;;; 196271;663649;Pathogens detection;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Antibiotics reduction with early mastitis pathogens detection for @ point of animal care usages;1/03/2015;31/08/2015;;"Blue4Green will develop a portable sample handling/sensing system for DNA and/or RNA fragments. The input to such a system is a raw sample of milk, containing the bacteria to be analysed that causes mastitis. Most of the time treatment starts without knowing the responsible pathogen. Often, the wrong (or not most optimal) antibiotic is used as treatment. When therapy fails, new mastitis incidences and prevalences are rising. To test, at this moment farmers collect their samples in testing tubes. These tubes should be transported and send to a laboratory. Within the laboratory, the fluid is tested and the farmer receives the results within three (or more) days. The new technology, concerns a more rapid detection method. Within the technique of B4G, it is possible to know which pathogen is responsible for the inflammation to treat mastitis infection within three minutes instead of three days (or more) since the farmer can test it by himself. With a rapid mastitis pathogen test:
- less mastitis incidences occur
- reduce of revenue losses (less new infection)
- there will be less use of unnecessary antibiotic
- more milk will be produced
- a better dairy cattle lifetime will be developed, resulting in a better return on investment for the farmer per cow

Detecting mastitis at an early stage is a new competitive eco-innovative process that contributes to a more resource-efficient, sustainable circular economy. Continuing population and consumption growth will mean that the global demand for food will increase for at least another 40 years. Growing competition for land, water, and energy, will affect our ability to produce food, as will the urgent requirement to reduce the impact of the food system on the environment. Extending the lifespan of dairy cattle by combating mastitis with better insights @ point of animal care using innovative diagnostics tools will lead to a proper use of resources hence a more the efficiency use of raw materials.";71429;50000;H2020-SMEINST-1-2014;SME-1;BLUE4GREEN BV;NL;;; 196311;664200;LEGEND;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;LEGEND, Sport goes viral;1/02/2015;31/07/2015;;"We are building an ecosystem of tools and apps to key agents of the sport sector. We see it as Google does with its platform. Their core is Search but then it provides with dozens of tools like Gmail, Calendar, Youtube or Analytics so user stay in their platform. Using sport as the soul of our platform we have started building this ecosystem.
Currently, we have developed a tournament manager where league and championship organizers can manage them. We allow them to create as many tournaments as they need, create teams and assign them players. They can organize almost every league or championship that may come to your mind.
With this tool, public (local government, Universities or Schools) and private (sport facilities, individuals, federations, associations, etc) managers from all around the world can send real time alerts, manage the classifications in an easy way, generate automatic calendars, publish the rules and news, define roles as referees or team managers and many more features to come.
We have also developed mobile apps for following the league but also the users can organize their friendly matches, comment on them before and after the match, check the results of their friends and to share them in other social networks.
Not only we ease the organization of the matches but we also motivate them to report the results by adding an algorithm to calculate their skill level of every sport. We have also added gamification technics to the app so users can get badges depending on their results. Finally, users can track and check all their stats and historical results.

LEGEND project will help miLeyenda to create a feasibility plan for going international. Currently, we have acquired more than 120.000 users in 3 months and we are ready to go a step further.";71429;50000;H2020-SMEINST-1-2014;SME-1;MILEYENDA ENTERTAINMENT SL;ES;;; 196270;663639;Space-COTS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;High-tech commercial-off the-self electronics low-cost qualified for space;1/03/2015;31/08/2015;;"Spectrum ARC GmbH provides an innovative state-of-the-art qualification scheme (approved by the German Space Administration DLR ) for commercial-off-the-shelf (COTS) components relevant for space and harsh-environment (radiation) applications. The space electronics market is currently dominated by US-Corporations and therefore underlies the restrictive barriers of international traffic in arms regulation (ITAR) , retarding the space industry growth and raising their cost significantly. Well offer so called Space-COTS by qualifying (testing) COTS from specific manufactures in different quality levels. This will enable space missions to have access to highly efficient, compact and light-weight new generation technologies at a lower price.
Low-cost Space-COTS let us introduce high reliable electronic products not only for space but also for extreme-environment applications on earth, e.g. radioactive environs (power plants, research labs, nuclear medicine, etc.), hot (deserts) and cold (Antarctic) places. As technology demonstrator well build a reliable and modular platform (box) consisting of a control and a removable sensor unit to be used in different environments as a Remote Monitoring System (RMS).
Europes mission of advancing non-dependent and competitive technologies in the space sector is fully supported by this project.";71429;50000;H2020-SMEINST-1-2014;SME-1;SPECTRUM ARC GMBH;DE;;; 196256;663483;ADS Project;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Autonomous Dronistics for Security (ADS): optimized services with fleets of flying robots;1/03/2015;31/08/2015;;"Flying drones promise to replace many civilian services currently requiring humans by means of robots performing product delivery, agricultural monitoring, inspections and maintenance, damage assessments. For this vision to be concretized, drones need to be safe, reliable, available on demand and most importantly fully automatic. This revolution is facing three challenges: the design of services that are possible to be executed within the regulations; the development of landing stations that the drones can exploit as docking point to recharge their batteries; the development of a master-control software that deals with coordination and optimization of the flights and operations of the drones performing the service.
The project Autonomous Dronistics for Security (ADS) is addressing the key technical challenges that all drone automation companies are facing today and that, if solved, will open the drone services market to existing and new industries. ADS innovation will solve these challenges by the use of a platform managing transparently operations with small multi-copters and a network of landing/recharge stations. The ADS system controls navigation, video feeds from the drones, and the operation strategy in a fault tolerant and law-abiding way. The software is able to program the flight plan best for each individual drone taking into account dynamically its role in the overall mission; The hardware ensures a permanent operation of the drones despite the limited autonomy and range of drones. The development of this innovation will allow for the first time to coordinate and manage in a fully automated way fleets of drones. The feasibility study of ADS focuses on one particular business case: the use of drones for automatic video-surveillance and alarm response.";71429;50000;H2020-SMEINST-1-2014;SME-1;ARCHON TECHNOLOGIES SRL;IT;;; 196227;663065;MAMANUCA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Microfluidic Advanced Manufacturing of Ultrasound Contrast Agents;1/02/2015;31/07/2015;;Tide Microfluidics is developing a patented technology capable of increasing the diagnostic capability of ultrasound. We have an advanced microfluidic manufacturing technique for producing ultrasound contrast agents (UCA) of controlled size to enable 20 times clearer images. Our uniform UCAs are unique, as current UCAs are composed of wide size distribution microbubbles, making them less effective. We aim to develop our technology into a bedside production device, which would lead to a reduction in diagnostic imaging costs, as ultrasound is cheaper than MRI or CT, and gives better images for faster and more accurate diagnoses. We would use Phase 1 funding to commercially and technically assess the feasibility of our device. We need to understand the users requirements and how best to fit into their workflow, as well as how to create a robust, reliable and user-friendly design. Economic viability will be studied, as pricing must be cost effective or market uptake will not occur. Finally, we will investigate the clinical validation needs and level of medical certification required for our bedside production device to be accepted in Europe, the USA and the rest of the world. This knowledge on feasibility, cost pricing and validation defined in Phase 1 would work as a roadmap for our development during a Phase 2 project. Thus, exploitation of SME instrument Phases 1 and 2 would secure the continuous development and validation of our device allowing for a rapid market entry, bringing a valuable tool to the end users and reducing healthcare costs. We aim to enter the ultrasound imaging market with our bedside device. Currently, more than 3 million ultrasound procedures using UCAs are carried out each year worldwide, with the European market alone worth $46 million. Ultimately, our vision is to become the worlds foremost supplier of UCA production devices delivering high definition contrast agents, enabling clearer diagnostic images for more effective patient care.;71429;50000;H2020-SMEINST-1-2014;SME-1;Tide Microfluidics B.V.;NL;;; 196296;663957;MED1C;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;MED1C : Video Management in Medical practice;1/02/2015;31/05/2015;;"Med1c goal is to solve needs of video usage within medical community. Video is increasingly being the basis for medical interventions and clinical story of patients. While some medical specialties use it more than others, video usage is experiencing a growing tendency in all of them.
Med1c main features include a user friendly interface, fixing the complexity of having many video formats, allowing to tag and label actions within an intervention, reducing reports and video storage solely to relevant parts, allowing video mining for best case solutions across data bases, and offering a cooperative solution while reducing costs, among others.
At the moment, generic solutions or standards to cope with video usage needs are non-existent within medical environment. In the same way images were fixed with PACS some years ago, now is time for video application. Even there are some few proprietary solutions made by Medical HW manufacturers, they are expensive in terms of acquisition and maintenance, and do not allow integration in open platforms like Windows, which Med1c is based on, not to mention their very limited functionality.
The target market is the health sector, being doctors and health professionals its main potential users. Therefore, in order to adapt the Med1c tool to every individual purpose and medical speciality, 1d3a already has cooperation agreements with some hospitals such as the ALTHAIA Foundation (ES).
Med1c software solution has a solid foundation, since it is based in Er1c, launched 7 years ago by the SME 1d3a to cope with similar needs within the sector of Elite competition in sports. Some of their main customers are FC Barcelona, Aspire (QA), CSKA (RU) and FIBA.
The objective of Med1C in the Phase 1 of the SME Instrument is to complete a feasibility study for all relevant medical cases including at least two EU countries. Moreover, the proof of concept for three applications (bronchoscopie, gynecology and oncology committees) will be developed.";71429;50000;H2020-SMEINST-1-2014;SME-1;1D3A ANALOGICO Y DIGITAL SL;ES;;; 196265;663547;Ph1ProHap2;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;hapticom launches the worlds 1st special tablet for over 20 million visually impaired people in the EU, enabling them access to barrier-free digital information and communication with all of society;1/02/2015;31/07/2015;;"Within the EU there live far more than 20 million blind and partially sighted people. There are even over 150,000 deafblind people who miss out seeing AND hearing at the same time. Most of the blind suffer from strongly limited communication and often live in huge social isolation. Even the UN and also EU parliament have already stipulated that a specific product solution for particular blind is needed. This mobile device ought to offer barrier-free communication and information to assist those people daily lives.

Therefore, the SME hapticom, an academic spin-off, develops the worlds first smartpad and corresponding ICT infrastructure for visual impaired. The device is named haptiPad and similar to a special haptic multi-functional pad or tablet. This innovation will change the life of blind people in whole Europe radically and strongly foster integration and inclusion.

Due to the groundbreaking chances the haptiPad offers, it addresses a huge market. High social gains, employment and commercialisation potential can be expected. Via several governmental fundings and the international investor Wayra (Telefonica telecommunications group) a convincing working prototype (TRL 6) is already developed and successfully tested.

Due to several (inter)national business concept contests the innovative business model of hapticom got very challenged and thus, advanced and was rewarded highly many times. The competent team intends to prove the adaptability and viability of the projects concept and product solution on a European level with the help of a feasibility study. At the end of phase 1 SME instrument hapticom aims for reference customer for the commercial beta version of the haptiPad to finally successfully finance the growth of the venture.";71429;50000;H2020-SMEINST-1-2014;SME-1;HAPTICOM UG (HAFTUNGSBESCHRANKT);DE;;; 196368;665770;CHIRALSENSE;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;CHIRALSENSE : Sensing Chirality using cavity-enhanced polarimetry: advances in sensitivity and time-resolution;1/04/2015;30/09/2016;;"Chiral sensing is crucial to many fields, constituting a multibillion Euro industry. The polarimetric techniques of optical rotation (OR) and circular dichroism (CD) are the most widely-used techniques for the analysis of chiral samples, ranging from the measurement of protein structure, to quality control in the pharmaceutical, chemical, cosmetic, and food industries. In general, the OR and CD signals are very small, which place severe constraints on detection sensitivity and time-resolution. Through the ERC grant TRICEPS, we have developed a groundbreaking cavity-based polarimeter [Sofikitis et al. Nature 514, 76 (2014)] with 3 main advantages: (a) The OR and CD signals are enhanced by the number of cavity passes (typically 1000); (b) birefringent backgrounds are suppressed; (c) signal reversals give absolute polarimetry measurements, not requiring the sample to be removed to measure a null sample. These advantages represent orders-of-magnitude improvements in sensitivity, acquisition time, and sample size, with respect to commercially available polarimeters, and will reduce measurement time, sample sizes, and costs in the chiral sensing industry. We propose, through CHIRALSENSE, to: (1) file a non-provisional US patent application, to follow our filing of a US provisional patent application for our polarimeter, which will provide IPR protection for the first stages of the product development; (2) demonstrate our existing CHIRALSENSE polarimeter to leading polarimetry companies, by performing measurements on commercial-standard samples; and (3) adapt our polarimeter to measure complex samples separated using HPLC (high-performance liquid chromatography) for analytical chemistry applications, to be demonstrated to leading HPLC companies.";150000;150000;ERC-2014-PoC;ERC-POC;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;;; 196281;663776;MicroInstrmntsBP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Novel Materials and Manifacturing Process Enabling Wristed Micro-Instruments: Business Feasibility Of Surgical Applications;1/01/2015;31/05/2015;;"MicroInstrmntsBP aims at planning the best business approach to the commercialization of micro-surgical instruments with the same dexterity of state-of-the-art instruments but smaller in size. The reduction in size allows the instruments to be introduced and used in smaller surgical fields and will open up robotic micro-surgery and endoscopic applications, that are currently beyond the capabilities of state-of-the-art products and have an estimated market size 10x the current 2014 market size for wristed surgical instruments (0.5 Billion USD).
Micro-wristed instruments are enabled by a proprietary, integrated design and a proprietary manufacturing process. Medra's design & manufacturing process for 3d micro parts allows parts to mate together with high precision. Current manufacturing technologies are limited in the fabrication of small 3d parts, especially parts for assemblies, by limits on the achievable geometry of the parts and their tolerances. We have overcome such limitations and are able produce very precise small parts in very hard and high yield strength materials. Such an approach allows to counter the weakening of the parts due to the scaling down of the dimensions. 5 month out goals are international IP filings and definition of first viable product based on surgical procedure-specific market size and risk-adjusted business opportunity.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEDRA SRL;IT;;; 196250;663410;AB ENGINE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Advanced Back end as a service Engine;1/03/2015;31/08/2015;;"AB ENGINE aims to launch in the market an advanced Mobile Back end as a Service (MBaaS) framework capable to provide mobile app developers with an effective and complete back end suite ready to use for boosting the realisation and the management of mobile application by using tailored and customised functionalities.
In the very next future the mobile apps will become the main tool of interaction among organisations and their customers: the needs of creating apps capable to interact with users and made them connected and engaged will arise and multi-channels functions will be the main features the mobile apps will have to provide. Such expectations are confirmed also by the forecast of the Mobile Back end as a Service market, that is expected to reach 5.9 Bln in revenues by 2017 growing at a CAGR of 104%.
AB ENGINE will address the MBaaS market, introducing an innovative solution, with respect to current state of the art, able to provide developers with ready to use applications, components and cloud infrastructure functionalities; thus it is the best solution for speeding up the mobile apps realisation and maintenance, reducing the costs, the time to market and the complexity of developing apps and on the other hand for scaling the apps up to millions of final end users and, supporting marketing features, data parsing, promotional channels (QR codes, landing pages, social networks integration, app store submission), CRM and networking features, such as Push Notification, Geo Fancy Messages and iBeacon.
With respect to the current MBaaS competitors, AB ENGINE will represent a disruptive innovation in the market, which is expected to boost AppsBuilder companys growth triplicating the annual turnover and work force within 3 years after the investment with a total ROI of approximately 230%.";71429;50000;H2020-SMEINST-1-2014;SME-1;APPSBUILDER SPA;IT;;; 196397;666513;SDO-MET;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014;H2020;Automatic Rail Safety Solution;1/04/2015;31/07/2017;;By 2025 1800km of rail lines will be automated worldwide. With the increase in automatic train operation comes the need to create an innovative platform and track protection system to ensure the security of passengers while maintaining increased efficiency in public transport. According to the European Railway Agency in 2012 there were a total of 5122 railway incidents involving people across Europe of which 1016 were serious injuries, 1133 were deaths and 2973 were suicides. The combined costs of fatalities and serious injuries cost the EU more than 1.5 billion euros in 2012. SDO-MET (Metro Object Detection System) is an innovative technology that aims at helping usher in the next era in automated public transport. Our platform and track security system provides a safer, lower cost, and easier to install alternative to current systems. Using an innovative system of sensors and cameras our goal is to make metro platforms and track areas safe and efficient for users and operators of automated trains. Our goals for phase 2 are to further develop and refine SDO-MET in order to have a market ready product. Our main focus, on a technical level, will be the implementation of the two SoA visual systems necessary for SDO-MET. The potential customers are the main operators of the railway sector such as Barcelona Metropolitan Transport, Metro de Madrid and Brussels Metro with whom we currently have trade relations. Other potential customers include project engineers and manufacturers /distributors of railway equipment such as SIEMENS, BOMBARDIERS, THALES, etc. During the development of our first prototype over the past 5 years we have developed a business plan and commercialization strategy. These and other feasibility activities, along with the willingness to pay already expressed by our collaborators, makes us confident that SDO-MET has market scalability and will be successful on a global scale. The potential worldwide market is for SDO-MET is 497 metro lines (452.7 B ).;1481155,5;1036808,85;H2020-SMEINST-2-2014;SME-2;AUTOMATITZACIO DE PROCESSOS I MEDIAMBIENT SL;ES;;; 196255;663477;BAMBENG;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;New BAMboo ENGineered bio-material for sustainable building components;1/02/2015;31/07/2015;;"Our proposed technology uses bamboo for manufacturing a unique new bio-material which has the potential to replace most commonly used structural materials such as concrete, steel and timber. This novel process will not only ensure the sustainable supply of raw materials via environment friendly new solution in construction industry, but will also provide participating SME with the opportunity to derive an ongoing income.
BAMBENG proposal outlines the opportunity to develop an innovative technological process which will produce a new constructional product, chemical free and environmental friendly (avoiding the use of toxic and polluting glues) with supreme technological, economic and environmental footprint performances. That would make BAMBENG advantageous competitor and feasible alternative as BAMBENG structural material, represents the best performing material for supporting structure for seismic building.
BAMBENG is obtained by a simple chafing and pressure welding process, producing a semi-finished completely biological new component. The process in chemical free, energy saving and with a very low footprint,
Compared with the most direct and similar competitive materials (wood, glulam and glubam) BAMBENG offers better technical performances and up to 45% of cost savings (based on Cost Structure Analysis).
BAMBENG is worth to invest in because it is a combination of proven technology and novel application of demonstrable technology and methods which have both economic & environmental benefits:
- Development of bigger structural components for buildings sector for easy substitution of current material like steel, aluminium, concrete, and even timber,
- Development of building design to exceed seismic and hurricane requirements,
- Transfer to other sectors such as interior and exterior architectural, packaging and design artefacts,
- Improvement of local bamboo crops at EC level, and
- Potential to license the technology to SMEs throughout the EU.";71429;50000;H2020-SMEINST-1-2014;SME-1;CARTACCI BRUNO & C SNC DI ALESSANDRO E LEONARDO CARTACCI;IT;;; 196306;664103;SiMAX;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;SiMAX translation machine for sign language;1/02/2015;31/07/2015;;"The Austrian SME SignTime is optimally combining its expertise on translation of content into sign language and on development of ICT tools in this context.
SignTime`s recent innovative solution SiMAX is a translation machine: The software is operated by a human translator who only needs to adjust translations suggested by an intelligent, learning algorithm based on a learning database. The resulting translation is then signed by an avatar and delivered as video.
This is very cost efficient compared to conventional production of translation videos in a studio with human translators signing.
Among all approaches researched so far in academia the SiMAX technology is closest to market and the only one reaching a feasible quality of facial expressions and emotions essential for understanding due to their grammatical meanings in sign language.
Business opportunities are enormous associated with any information needed to be made accessible to the deaf community (by integrating the translation video next to the original content): TV, film, internet, other media. Upcoming accessibility regulations favour market growth and demand.
Thus, this project fits perfectly with our overall strategy as well as with the requirements of this SME call, adding a completely new, market changing solution.
The feasibility study aims to pave the way to market introduction covering: Development of demonstrations, collecting technical and economic feedback from key market segments, from experts and the deaf community and incorporating all insights including market study results into a technology adaptation plan and a detailed business and market entry plan.
Apart from providing significant growth options to the company, SiMAX can essentially contribute to increase accessibility to information society for the deaf community thus promoting inclusion and social cohesion.";71429;50000;H2020-SMEINST-1-2014;SME-1;Sign time GmbH;AT;;; 196352;665635;MISSION;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Mid Infrared SpectrometerS by an Innovative Optical iNterferometer;1/06/2015;30/11/2016;;"The MISSION projects aims at bringing to the market a revolutionary concept of mid-infrared (MIR) interferometer, for a new generation of compact, low-cost, rugged spectrometers. Many applications of chemistry, materials science and life sciences require analysis and identification of substances based on their vibrational absorption spectra in the MIR. Time domain vibrational spectroscopy techniques such as FTIR and 2DIR are based on the use of an optical Michelson interferometer, producing two identical phase-shifted replicas of the input beam. Phase determination is technically very challenging and requires tracking with an auxiliary laser beam and in some cases the use of active stabilization approaches, with feedback control on the interferometer arms, greatly increasing device complexity. We have recently introduced a new optical interferometer, called TWINS, which exploits material birefringence to impose highly controllable delays. TWINS has the advantages of being inherently phase stable, compact, rugged, highly reproducible and potentially low cost. The TWINS concept, for which a patent has been filed, was successfully demonstrated in the visible and the MIR spectral ranges. It is the goal of the MISSION project to unleash the innovation potential of TWINS, by developing, technically validating and bringing to the market a TWINS-based MIR interferometer, paving the way to a new generation of compact and low-cost analytical instruments for a wide range of applications. We have identified a suitable material with broad MIR transparency and huge birefringence: calomel. The MISSION project aims at: i) building a TWINS device based on calomel; ii) demonstrating its application to MIR spectroscopy; and iii) turning it into a commercial product, to be sold either as stand-alone device or as part of a spectroscopic instrument. We expect that TWINS will significantly reduce the cost of MIR interferometers, thus widely broadening their application portfolio.";149625;149625;ERC-2014-PoC;ERC-POC;POLITECNICO DI MILANO;IT;;; 196282;663790;SAFETY4WORKERS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Breakthrough for outdoor autonomous heavy machines: Safety-directed collision avoidance system for workers based on UWB radios with performance level;1/02/2015;31/07/2015;;"Worker severely injured on the job by a moving machine!
- Industrial enterprises worldwide need to avoid such a headline.

Safety at work is a hot topic in industrial companies today. The International Section of the ISSA (International Social Security Association) on Prevention in the Mining Society formulates the Vision Zero for 2020. A huge amount of money is invested in prevention, more than 900M per year only in Germany. Especially accidents with mobile machinery are crucial with around 12.000 accidents caused by collisions between construction machine and pedestrians resulting in an economical loss of 1 billion euro per year only in Germany.

The vision of industrial companies is to deploy autonomous moving machines (AMM) across different application scenarios. As the area of machine operation can typically not be separated from walking workers, a basic requirement is that AMMs must detect these persons reliably in the critical danger zone and must be able to react autonomously in order to avoid fatal collisions. Safety-directed pedestrian recognition is still todays blocking point for outdoor operations, as conventional sensors like laser, cameras, radar or ultrasonic fail due to the harsh operational conditions and highly dynamic changing working environment.

Comnovo is proposing combined active and passive Ultra-Wideband sensors for safety-directed, bi-channel human being detection.

The main objective of phase I of the SAFETY4WORKERS project is to explore the technical feasibility and commercial potential by combining D2SENSE with UWB radar sensors for human being detection to reach a PL. Furthermore, the business plan will be further developed based on the two divers use cases Charging Cars in Coke Plants and Autonomous Mining Systems, which will be elaborated with support of European partners committed to this project.";71429;50000;H2020-SMEINST-1-2014;SME-1;COMNOVO GMBH;DE;;; 196299;664011;PRINTOO;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;PRINTOO - flexible, thin, printed electronics prototyping kit;1/02/2015;31/07/2015;;"Ynvisible is a start-up company in Printed Electronics (PE) with the vision of bringing everyday objects and surfaces to life, making them more useful and enjoyable. In order to democratize access to revolutionary new PE technologies developed in Europe and North America, Ynvisible developed its first consumer product, Printoo.
Printoo is a flexible, modular, electronics prototyping kit which allows anyone to create new interactive products using thin, flexible, PE components, including Ynvisibles displays. The project was launched through a Kickstarter crowdfunding campaign, which was hugely successful and received highly positive feedback from educators, tech enthusiasts and entrepreneurs, as well as wide media publicity highlighting the innovative nature and market potential for Printoo. The crowdfunding campaign allowed us to identify three main market segments: education, maker community and design & prototyping. Printoo is an essential prototyping platform for entrepreneurs and makers looking to develop and prototype new intelligent products where flexibility and form-factor are essential requirements.
Educators have demonstrated great interest in Printoo as a tool to develop creativity, design and do-it-yourself technical skills in students at any level of the learning curve. As an educational tool, Printoo can greatly contribute to European-wide initiatives such as the eSkills for jobs 2014 initiative, in which Ynvisible is already enrolled as a partner. In addition, the commercialization and value chain creation impacts of Printoo will strongly contribute to European goals set out in the ICT 3 programme directed at TOLAE technologies.
With this feasibility study, Ynvisible intends to undertake an in-depth analysis and market testing for Printoo, to better define the business models for each of the pre-identified target markets, as well as the global strategy to turn Printoo into a global success.";71429;50000;H2020-SMEINST-1-2014;SME-1;YD YNVISIBLE SA;PT;;; 196235;663156;GEM E-drive;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;In-wheel electric drive for E-commercial vehicles;1/01/2015;30/06/2015;;"The main goal of the innovation project is to develop a new electric drive inside the wheel for mobility market of electric buses and electric transport vehicles (E-commercial vehicles). The classical conceptual solution with electric motor positioned at the place of combustion engine has several drawbacks: heavy weight since mechanical transmission is needed, complex solution with many moving parts, low efficiency because of transmission losses and need for extra place. With our new solution that is simple (direct drive with no mechanical transmission), efficient (up to 92%), light (lighter up to 50%) and cost effective (simple production) we want to enhance the usage of electric drive for city traffic (buses and vans). In addition, our developed technology is easy adaptable for different applications and power levels due to its unique modular concept. Therefore our new electric drive solution together with low driving cost using electric energy and with reducing pollution, noise and C02 emission in cities and urban areas, especially in Low Emission Zones (LEZ), represent excellent business opportunity for emerging E-mobility market of commercial vehicles and thus also realizing a company vision to become an important European in-wheel drive producer.
For the realization of the project a feasibility study is required with delivered elaborated business plan as an outcome with following objectives:
technical feasibility study of in-wheel electric drive development for 25kW power and customization to other applications modular concept
impact study of regulations and homologation on the product development
market analysis and detailed customer requirements study
strategy definition for entering to the market and product development
analysis of manufacturing process and cost evaluation with optimal process definition
risk evaluation with measures for risk minimization
identify strategy for IP management with timeline";71429;50000;H2020-SMEINST-1-2014;SME-1;GEM MOTORS, RAZVOJ IN IZDELAVA INOVATIVNIH ELEKTROMOTORJEV DOO;SI;;; 196266;663564;ASC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Amorphous Speculative Compression;1/03/2015;31/08/2015;;"Camera located outside the protective environment of Earth's atmosphere and magnetic fields is exposed to the very harsh radiation. Space based electronic components are produced in a different way, and much more expensive, than the ones built for use on our planet. To make situation even worse, the processing power of radiation hardened microprocessors is much worse, than what we normally expect from the CPU. Long distances, that space brings and radiation also diminish the possible communication rate, while radiation problems with storage devices complicates even storing the filmed material for later compression and transmission. Because of all these problems, humanity was never even close to be able to establish a decent video link with some other celestial object. To overcome this problem, we developed a different type of picture and video compression method.

ASC compression is a lossy type of compression, that differs from other types of lossy compression because it removes the main amount of data before any complex mathematical functions are executed. Other types of compression perform a complex transform first and remove the less important data later. This makes standard compression types much more resource hungry, than the ASC compression.

Unlike jpeg and mpeg compression, where compression is done in squares, that are always positioned at the same positions of the picture, ASC method builds the picture around the most prominent points of it. This helps the encoder to easily find similar patterns in different pictures or parts of one picture but also removes the block appearance at high levels of compression. At high levels of compression, the picture simply looses more and more details. Testing so far has proven the truth of our expectation, that the quality of the picture doesn't deteriorate fast with increasing compression.";71429;50000;H2020-SMEINST-1-2014;SME-1;UROS KEJZAR;SI;;; 196240;663198;BLACKBINDER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Black Binder, all-in System of Digital Scores;1/03/2015;31/08/2015;;"'Musicians play the scores basically like they did 200 years ago.The musician must hand off the instrument to turn the page and it is complicated passing scores and maintain proper posture. They also spend large spaces and budget to store and preserve scores that are easily deterioorated. In addition, collaborative work is a hard task due to the lack of synchronization.

With BlackBinder solution, New Music Now will offer the music community a 'pageless scrolling' technology-based system that allow: Continuously display of scores at the pace the musician sets and improve in this way the interpretation, allowing the musician being holding the instrument at any time (Page concept disappears).
Synchronization for collaborative work is possible, annotations writing and sharing, and specific functionalities for every instrument.

To benefit from this, the musician must download to his tablet the bbApp application which is complemented with 3 other services/products that offer maximum utility being used supplementary:

bbSet: physical device that supports the tablet and allows the user to interact with the app by wireless pedals.
bBinder: storage space in the cloud for scores downloaded from bbsore or uploaded by the musician from his own background music and turned into XML format.
bbStore: online store for individuals or publishers to sell scores with bbsecure technology anti-piracy. Impossibility to get the score of bBinder and send it to another user. Its visualization is only possible with the bbApp. Scores are also encrypted (for user recognition) so if they were finally removed from the bBinder, even so, they cannot be used for another user who is not the owner.

Taking into account the high number of musicians worldwide, the described needs and the BlackBinder characteristics show a clear link between the really large gap in the musicians environment and the great business opportunity for the proposed solution.'";71429;50000;H2020-SMEINST-1-2014;SME-1;NEWMUSICNOW SL;ES;;; 196267;663597;MeRIT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;MeRIT - Maximising Renewable Energy Integration;1/03/2015;31/05/2015;;"Esave has designed a Hybrid Energy Storage Solution which uniquely integrates flywheel kinetic energy storage, battery energy storage and power electronics technologies. MeRIT is ultra-fast responding, provides greater reliability, longer lifecycles, is environmentally sustainable, safer and offers overall best total cost of use (TOC) than any other solution.

The overall objective of the MeRIT project is the commercialization of a new Hybrid Energy Storage System that maximizes renewable energy integration through provision of fast-responding ancillary services, dramatically reduces the 60% - 70% capacity losses of wind and solar generation due to intermittency and no storage; it also reduces curtailment losses through synthetic inertia.

MeRIT users will benefit from new ancillary services revenues, additional capacity revenues, reduction in curtailment losses and compliance with new grid code modifications.

The Esave management team is highly entrepreneurial and has extensive experience and skills in design and manufacture of power electronics, development of computer systems, software, provision of electrical power quality services and consultancy.

The objective of the Feasibility Study is to (1) Develop cost and payback financial models for the integration of MeRIT with wind and solar installations internationally. (2) Complete the planning process for the installation of a Demonstration System which will be installed on a windfarm in Ireland, controlled, monitored and validated by EirGrid, Irelands Transmission System Operator.

MeRIT is at the stage of TRL5 and an operational prototype system is ready for installation. Esave is partnering with Mainstream Renewable Power, a major wind and solar developer/operator, who will facilitate the installation on a windfarm that they operate. The Energy Research Centre, University College Dublin - Energy Institute, is also partnering and assist in renewable integration expertise and system modelling.";71429;50000;H2020-SMEINST-1-2014;SME-1;ESAVE CORPORATION LIMITED;IE;;; 196338;664738;PHOCCS;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Photon Cross Correlation Spectroscopy;1/05/2015;31/10/2016;;"Across Europe, nearly 250,000 people die every year of sepsis, a severe bloodstream infection. Detecting molecular biomarkers indicative of bacterial infection within a limited time is vital to enable targeted antibiotics therapy, limit the risk of antimicrobial resistance and reduce hospitalization costs. The key to success to fight sepsis is a fast detection technology that avoids the need for nucleic acid amplification processes and circumvents the limitations of fluorescence labelling.

The PHOCCS project aims at exploiting novel concepts based on PHOton Cross Correlation Spectroscopy to develop a breakthrough platform for ultra-sensitive detection of DNA biomolecules and assess its transferability into the large molecular diagnostics market. With its unique technology based on dynamic light scattering of noble metal nanoparticles, PHOCCS has several key advantages to enable commercial success: it is fast, quantitative, sensitive, specific and simple to operate.

Based upon original and patented intellectual property, PHOCCS is fully targeted to the development of a disruptive technology fundamental in strategic applications of molecular diagnostics to fulfil the industrial market needs. The PHOCCS project will bring the technology to a pre-demonstration stage for DNA sensing to strengthen the commercialization and licensing opportunities.";149984;149984;ERC-2014-PoC;ERC-POC;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196284;663811;BilletPro;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Development of a harvesting machine for short rotation plantations for the production of billets with advantageous properties in terms of handling, drying and storing;1/03/2015;31/08/2015;;"Plantations of fast-growing trees, so-called short rotation plantations (SRPs), are a promising way to produce large amounts of CO2 neutral energy. SRPs are usually harvested fully automatically with harvesting machines that directly chop the wood into chips which are then combusted in CHP plants. However, the chipping leads to losses of up to 30 % of the energy content due to microbial degradation of the wood during drying.
SalixEnergi Europa AB has developed an innovative new harvesting technology which enables a fast drying of the wood without any losses of the energy content. The rods are cut into pieces with a length between 12 and 24 cm (depending on the purpose), so-called billets. When stored in piles the good air circulation enables a fast drying while the bark protects the billets from microbial degradation. A first technical prototype has demonstrated the proper functioning and huge potentials of the technology. However, improvements and adaptations are required to achieve the market breakthrough. In this proposed project a feasibility study will reveal the technical feasibility of the envisaged improvements and the optimal way of implementation, while a business plan will show the optimal way of commercialisation.
The billet harvester will allow European energy farmers to use the full energetic potential of the wood and thus increase their income by up to 30 %, while the increased production of CO2 neutral energy per unit of area will help Europe to reach its goals of climate control. The improved profitability of SRPs will moreover lead to a further fast growth of the plantation area. At the same time SalixEnergi Europa AB will significantly grow in terms of turnover, profit and employment, reach the market leadership for SRP harvesters and expand its position as one of Europes leading SRP companies.";71429;50000;H2020-SMEINST-1-2014;SME-1;SALIXENERGI EUROPA AB;SE;;; 196220;663008;HitSeedSME-1-09-14;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;HitSeed application for the Horizon 2020 dedicated SME Instrument - Phase 1 2014. September 2014.;1/12/2014;31/05/2015;;"'HitSeed is conducting a feasibility study on their revolutionary Internet of Things (IoT) platform, which includes hardware, software, industrial design and software development tools. The platform is technologically novel, as it combines modern microcontroller-based hardware with touch display and graphical user interface providing unprecedented customer benefits, like low power consumption and significantly reduced unit cost. Most importantly, the IoT platform is disruptive, as it brings development costs down to completely new levels and shortens the IoT deployment time-to-market from 1-2 years to months or weeks while simultaneously reducing the risk level. It also allows the expansion of IoT solutions to domains that have not been feasible before, including e.g. mobile, 'fire-and-forget' type of IoT sensor and monitoring devices.
There is a clear customer need for our platform as many companies in Europe and globally struggle with finding a proper solution for their IoT needs or need to accelerate their product development to stay competitive. Potential customers vary from small startups developing consumer IoT products in various domains like household appliances or wellbeing to large enterprises needing a tested HW platform to boost their own product development e.g. for industrial clients. We estimate that the commercial potential for IoT devices based on our platform is 38 MEUR in 2017 with indirect impact being in the range of 600 new jobs in Europe, increased competitiveness of European industry, and an estimated customer value add of over 300 MEUR.
During the feasibility study we are planning to do an IoT opportunity identification, build a business plan, develop a minimum viable product for IoT including an industrial design, as well prepare to pilot the solution with a first customer. The outcome of the study is a clear plan for the next steps including potential application for the phase 2 of the Horizon 2020 dedicated SME instrument funding'";71429;50000;H2020-SMEINST-1-2014;SME-1;HITSEED OY;FI;;; 196351;665672;MultiRev;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Multi-revolution non-volatile magnetic sensors;1/01/2016;30/06/2017;;"Multi-revolution sensors that detect multiple rotations are being used in many areas of the automotive and automation industry. The current generation of discrete multi-revolution sensors has major drawbacks, such as complex architecture, limited applicability and high cost. MultiRev will demonstrate the proof-of-concept of a novel monobloc multi-revolution sensor based on non-volatile low power domain wall motion induced by the rotating fields that are being sensed to count revolutions. A large number of rotations can be sensed by combining multiple curved domain wall conduit devices with coprime numbers of loops developed with results from the PIs ERC starting grant. This novel non-volatile sensor will operate without power during sensing and only for eventual read-out power is needed. This new multi-revolution sensor will be disruptive by replacing current expensive and complex incumbent non-magnetic multi-revolution sensors by a simple energy self-sufficient magnetic device that will open up a large market by extending the range of magnetic sensors from the present sensing of only one or a few revolutions to the sensing of thousands of revolutions.The goal of this PoC is to: (i) demonstrate that the building blocks for the sensor developed in the lab can be combined and fabricated for reliable operation using industrially compatible processes to achieve volume production at competitive costs and (ii) explore exploitation routes by analyzing market, cost, and pricing and developing an IP strategy and business model. To achieve this, a postdoc and an engineer will be hired and external support will be contracted to support the team.
Our novel sensor solution for growing markets will generate high added value for European companies, which are under constant price pressure for their currently produced simple sensors. The high innovation level will secure the adoption of this high value technology with mass-market potential in Europe strengthening the economic area.";150000;150000;ERC-2014-PoC;ERC-POC;Johannes Gutenberg Universitaet Mainz;DE;;; 196252;663444;THEMOTION;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;TheMotion: Revolution in Motion;1/03/2015;31/08/2015;;"e-Traction Europe, a highly innovative company specialized in energy efficient electric powertrain technology, is developing a direct-drive in-wheel electric powertrain solution for city buses as well as for medium and heavy duty trucks, which is called TheMotion. By creating the most energy efficient electric powertrain solutions, environmental impact, energy consumption and cost of ownership of mobility are lowered substantially.
TheMotion is the only direct-drive in-wheel electric powertrain system on the market for buses and medium and heavy duty vehicles. The main advantages of TheMotion, direct-drive in-wheel electric powertrain solution are:
Zero emission system (huge contribution to lowering CO? emissions and air quality);
Significant noise reduction;
High efficiency (e.g. maximum elimination of transmission losses and optimal regeneration);
Decrease of the total cost of ownership;
Flexible production method and assembly makes product suitable for retrofit and new vehicles;
Design freedom for OEM (optimum use of available vehicle space due to very low build height of the axle).

Potential users are public transport operators, bus manufacturers and manufacturers of medium and heavy duty trucks (OEMs). The objective of this feasibility study is to further verify the technological, practical as well as the economic viability of the product. The 6 months of Phase 1 will be used to develop a detailed business plan, strengthen the relationship with potential customers and partners and define the technology. e-Traction intends to submit a Phase 2 application after finishing Phase 1.";71429;50000;H2020-SMEINST-1-2014;SME-1;E-TRACTION EUROPE BV;NL;;; 196225;663057;USELA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Useful energy from contaminated landfill gas;1/12/2014;28/02/2015;;"Cleanergy will plan and demonstrate (in phase 1 and 2) a solution for exploration and production of a technical solution that utilizes low-grade methane landfill-gas with a more efficient production of heat and electricity and better control of emissions from the combustion than existing technology. The combustion in the stirling engine application will be optimized. The project focuses on variations in the fuel which affect combustion and components. The challenge of Phase 1 refers to the varying gas composition and impurities. Research data shows that the gas composition and its compounds vary not only over time but also by season and weather. The project allows landfill-gas extraction to last long, be more predictable and stable and take care of pollution that would otherwise not be treated. In Phase 1 , we intend to identify various landfills where demonstrations can be made with different conditions and geography that reflects the market potential but also technical challenges. This way, we involve users in Phase 1 in order to better plan Phase 2. We will also examine if we need extra partners in Phase 2. A market survey will be conducted to know the proportion of landfills in Europe that have a gas collecting system and the landfills that flare. The flaring landfills represent the primary target in a first exploitation phase. A risk analysis will secure the measurements and method to be used in the demonstration phase in order to give valid results.
In Phase 1 an innovation strategy will be developed and the European dimension will be refined. We will investigate potential obstacles for the company's ability to be profitable in the exploitation phase in order to secure the return on investment.
Overall, the pilot will evaluate the feasibility of the concept and the idea for the project and innovation. The deliverable from phase 1 is a business innovation plan I.";71429;50000;H2020-SMEINST-1-2014;SME-1;CLEANERGY AB;SE;;; 196382;666206;WINTHERWAX;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014;H2020;WINdow based on THERmally modified wood with high performance WAX coating;1/03/2015;31/12/2016;;"M SORA and SILVAPRODUKT, two Slovenian SMEs dedicated to wood products and wood preservation present WINTHERWAX, a passive window made out of Norway spruce (Picea alba). Its thermally treated wood is processed through the unique SILVAPRO? patented process, and coated with an innovative preservative wax.
The result is a wooden passive window cost-effective (the window will be sold at a price of 369, beating the competitors), highly durable (class 1, more than 25 years fully exposed in the environment), that provides an excellent thermal insulation being highly energy efficient (Thermal transmittance = 0,09 (W/m2K)). It is eco-friendly (its innovative coating, which is a unique biocide-free wax that reduces cracking which is the main cause for wood decay), and with a high aesthetic value (the translucent wax allows this product to preserve the natural look of the wood, in contrast to current oils and varnishes).
The aim is to capture 4,1% of the wooden passive window market share from the EU.";1850115;1295080;H2020-SMEINST-2-2014;SME-2;M SORA TRGOVINA IN PROIZVODNJA DD;SI;SILVAPRODUKT PODJETJE ZA PROIZVODNJO IN PRODAJO SREDSTEV ZA ZASCITO MATERIALOV;SI; 196269;663622;VETBIOMAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Advanced material for the regeneration of joints in veterinary medicine;1/02/2015;31/07/2015;;"The main objective of VetBiomat is to undertake a technical and market feasibility study on an innovative regenerative medicine treatment for osteoarthritis (OA) in horses and dogs based on a new advanced material, HR007. The use of this material is expected to significantly increase treatment efficiency over currently marketed products and address the unmet need of achieving a cure for this disease in horses and dogs.

Osteoarthritis, a progressive deterioration of the joint cartilage, is a major economic problem in veterinary medicine. Currently, there is no cure for OA, and therapies available rely on reducing symptoms (corticosteroids, NSAIDs, and analgesics) or on the administration of glycosaminoglycans by different routes. No sound scientific evidence of efficacy for most glycosaminoglycans based commercial treatments has yet been obtained, especially when administered orally, nutraceuticals, which actually have the largest market share. Therefore, the market potential for a new efficacious, complex, and regenerative intra-articular product of non-bovine origin is very large.
ArtinVet Innovative Therapies, S.L., a new SME specialized in veterinary regenerative medicine, has a novel and unique multiple GAGs rich material of natural origin, HR007, for inclusion in new regenerative medicine based products for veterinary medicine. This advanced material has shown in vitro superior qualities to any other tested products in promoting cartilage regeneration and chondrocytes and mesenchymal cells migration. HR007 production has been standardized and industrialized.

Successful completion of Phase 1 of VetBiomat will yield a robust business plan for a much larger project that will seek funding under Phase 2 of the SEM Instrument, when clinical studies and product authorization procedures will be accomplished. Successful accomplishment of phases 1 and 2 will be essential for accelerating the growth of the SME ArtinVet and its international market positioning.";71429;50000;H2020-SMEINST-1-2014;SME-1;ARTINVET INNOVATIVE THERAPIES SL;ES;;; 196291;663913;WATLY;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;An autonomous and mobile water treatment plant powered by solar energy;1/02/2015;30/04/2015;;"Water and energy are highly interdependent and are both crucial to human well-being and sustainable socio-economic development. In 2014, the UN reports that 768 million people worldwide still do not have access to a safe source of drinking water, and more than 1.3 billion lack access to electricity.
We have developed the Watly unit with the goal of providing a solution for fast, simple and efficient wastewater treatment and energy supply in developing and/or remote regions. Watly combines cutting-edge technologies to offer i) complete sanitation for well, surface ground, sea or recycled rain water, ii) off-grid electricity from solar energy and iii) Wi-Fi internet connectivity, all in one portable autonomous unit.
Watly embodies the ambition of a European company to address a global market. The wide range of customers worldwide that could benefit from this all-in-one solution include diverse market segments such as: Governments and public institutions, Non-Governmental Organizations (NGO) and foundations, mobile hospitals, military organizations, hotels/resorts/businesses in remote destinations, massive open-air events, oil platforms, gas/oil & construction sites, etc.
Scale-up beyond our current prototypes and industrialization of the production process is the key to growth and expansion of our company taking advantage of a new market opportunity. In order to do so, we are applying for SME Instrument Phase 1 funds to: (i) elaborate an exhaustive technical feasibility study focused on scale-up beyond our current prototypes, design and industrialization of the final commercial unit of Watly-L; (ii) elaborate a detailed business plan for the commercialization of Watly-L at the conclusion of the envisaged Phase 2 project. If the results of the feasibility study, both from the technical and commercial point of view, are positive, we will proceed to apply for Phase 2 funds in order to carry out the abovementioned scale-up, product refinement and industrialization tasks.";71429;50000;H2020-SMEINST-1-2014;SME-1;ENRY S PLEX SL;ES;;; 196205;662804;ADA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Accelerating the Dissemination of Agluna(R), a clinically proven innovative silver ion based anti-microbial surface technology, from orthopaedics sector into the dental implant sector;1/02/2015;31/07/2015;;"The project objective is to confirm the commercial application of Agluna(R), an innovative silver ion based anti-microbial surface technology, to dental implants. Agluna(R) has already demonstrated a significant reduction in the incidence of post-operative infection in clinical use within the EU limb salvage market, and is being actively commercialised within the wider global orthopaedic market.

Implant related infections are associated with the formation of biofilm on the surface of implanted devices. This is a global problem with socio-economic costs recognised across a range of medical device sectors. The dental implant sector is actively searching for solutions to the problem of post-operative implant infection (peri-implantitis). With growing concern about antibiotic-resistant bacterial strains, the subsequent expected outcome following this project is for Agluna(R) to become commercialised in EU/global markets as a differentiated, cost effective and clinically proven technology utilising silver ions, a well-known biocide with very limited reported bacterial resistance.

Phase 1 will confirm a business plan for successful commercialisation of Agluna(R) in the dental implant sector. We seek confirmation of:

- the size and scope of the EU and global market opportunity in the dental sector;
- competing approaches to prevention and control of post-operative infection in this sector;
- market entry strategy taking account of EU and other international regulatory pathways;
- investment requirements, time to market, and return on investment.

Phase 1 is six months in duration; the principal deliverable is a fully substantiated business plan. This will provide the basis for Phase 2, in which Agluna(R) will be piloted on a dental implant product that is designed, manufactured and clinically tested in a human proof of concept study.";71429;50000;H2020-SMEINST-1-2014;SME-1;ACCENTUS MEDICAL LIMITED;UK;;; 196251;663424;BARAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Biomechancial Aneurysm Risk Assessment Trial;1/03/2015;31/10/2015;;The formation of aortic aneurysms is the by far the most common aortic disease and its prevalence (1%-5% in the 65\ population) strongly increases with age. Expensive aneurysm repair interventions (about 60k per year in Europe) are performed in order to prevent aortic aneurysms from rupture. However, oversimplified criteria like the maximum transverse aortic diameter or the aortic expansion rate are used to indicate aneurysm repair. These criteria fail to provide patient-specific (individualized) treatment indication, such that many patients are treated without a reason and health care resources are wasted. In contrast VASCOPS A4clinics software allows a detailed biomechanical rupture risk assessment, and hence, allows prioritizing patients according to their individual risk of aortic rupture. The market volume for such diagnostic information is estimated to 12000k per year in Europe. A4clinics is patented, CE approved and achieved already Technology Readiness Level 9. Despite first retrospective validation studies demonstrated the clinical benefit of the system large prospective validation is needed to fully convince clinicians and to commercially exploit the product. Consequently, the aim of this proposal is to develop a clinical validation plan for the A4clinics software, which is tightly linked to its successful large-scale commercialization. Key points are the definition of a targeted validation strategy and the installation of an effective network of clinical partners, who also should serve as national contact points for product commercialization. In addition early measures to gain awareness of the validation initiative and links to product distribution plans are investigated. The planning will be performed in collaboration with our clinical contact at Karolinska University Hospital in Stockholm, Sweden. Stockholm area screens for aneurysm patients, and, as such provides latest, and for most European countries, a future health care environment.;71429;50000;H2020-SMEINST-1-2014;SME-1;VASCOPS GMBH;AT;;; 196213;662899;RoadCast;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Dynamic Road Sign Casting;1/02/2015;31/07/2015;;"The project has the objective to industrialize an innovative, flexible and cost-effective dynamic road sign system as a valid alternative to the actual static road sign infrastructure on expressways.

The problem: Road signs in motorways sometimes do not reflect road conditions or properly inform drivers due to their static nature. In particular speed limits and road works signs often change due to different conditions and need to be replaced manually. This exposes road maintenance personnel to dangerous works and results in higher life-cost cycle per sign.
The solution: An innovative low-cost, low-power, low-maintenance, and highly flexible variable message road sign based on paper-display technology and centrally controlled has been designed and prototyped that demonstrate less life-cycle costs and higher flexibility. Road Builders and maintenance authorities as well as system integrators for road infrastructures are a Potential Market. Preliminary assessments have been conducted that indicate a great potential of the innovation. The business potential of the solution could also extend to other markets (such as digital out of home) but the project will concentrate to transportation to maximize the probability of success of the initiative.

The business approach. Customers have already been approached and more will be approached directly or via stakeholders and business partners from the actual portfolio of the proponents. Dissemination and marketing promotion will be carried out to achieve a critical mass of interested customers for the industrialization phase. Feasibility will also target pilot deployment with interested customers.

Objective of the feasibility study is to provide the basis for the solution and the business approach minimizing the risks for the proponents and the early adopters in the industrialization phase while augmenting the competitive advantage.";71429;50000;H2020-SMEINST-1-2014;SME-1;AITEK BV;NL;AITEK SOCIETA' PER AZIONI;IT; 196237;663178;REFEREE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;pREcise Fluids mEteRing EquipmEnt;1/01/2015;30/04/2015;;"No one likes to be cheated, neither on purpose, nor accidentally. 2014/32/EU Measuring Instrument Directive (MID), mandatory from April 2016 on, works towards guaranteeing the rights of the end consumer, as well as providing an uniform European Market for all manufacturers of Measurement Instruments (MIs).

We are FLEXBIMEC International SRL, an Italian multinational company situated in Albinea (North of Italy) with 26 employees, 8.6M turnover, 2,500 customers base and a track record of 40\ years experience successfully providing MIs for fluid/fuel metering and dispensing devices. We lead the Italian market (>35% market quote) and are a relevant European and worldwide player (>55% exports). Passionate about innovation, as we are, we will take this EU directive as an opportunity to commit a deep revision of our current technology and go a step further in the direction of offering our customers the added value they deserve while further protecting end consumer rights.

REFEREE is a technology upon which we will build a brand new line of fluids metering & dispensing equipment conforming 2014/32/EU MID Norm, that will comprise an optional proprietary air separation subsystem (to further increase accuracy, equipment lifetime, make the workplace safer and cleaner for workers and lower environmental impact). We will focus on Automotive (our all-time focus), Industrial (mechanical industry of production of cylinders, cranes, gear reducers, vehicles and motors) and will start exploring Maritime (new market!) sectors, and specifically target electric oil and fuel pumps in the garage segment. Results obtained from our on-going development makes us confident in achieving our goal of further increasing our sales up to 60% in the EU and consolidate our international presence.";71429;50000;H2020-SMEINST-1-2014;SME-1;FLEXBIMEC INTERNATIONAL SRL;IT;;; 196210;662883;INNO-HTM;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Innovative eco-friendly heat transfer media;1/03/2015;31/07/2015;;The proposed project is a feasbility study in order to investigate the feasibility of an innovation action comprising demonstration and market introduction of heat transfer media based on synthetic diesel that is more efficient and sustainable than exisiting products on the global market. The innovaiton meets the needs expressed both from customers and policymakers. The feasibility study comprises one work package with 8 tasks. We will map where demonstrations could be made with varying technical issues and geographical location which links to market potential and technological challenges. In this task users will be involved in order to make an optimal plan of phase 2. We will also investigate potential partners in Europe for phase 2. A market survey on how many potential users, segmented in the markets where the applicant has a pending or active patent, and include the primary target group in phase 3, will be performed. A risk analysis will be made to secure the measurement values and methods to be used in the demonstration phase to provide valid results. We will prepare an environmental production declaration (EPD) pinpointing the environmental benefit of the innovative technology. The EPD is proceeded by a life-cycle analysis of the technical solution. We will make a elaboration of the European dimension and analysis of obstacles that may hinder the ability to increase the profitability in the company through the innovative HTF in order to create the best possible return on investment of the innovation activity.The deliverable of phase 1 is a Business Innovation Plan 1 which will present the predicted business- and market possibilities.;71429;50000;H2020-SMEINST-1-2014;SME-1;AVANTHERM AB;SE;;; 196276;663699;SMILE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Slimming MIcroaLgae Extract : Development of a new highly effective microalgae-based slimmingingredient for nutraceutical applications;1/03/2015;31/08/2015;;"The SMILE project aims at developing a microalgae-based innovative natural marine ingredient with scientifically demonstrated benefits on weight management and metabolism issues.
Obesity and overweight concerning 37% of world population in 2013 (The Lancet, 2014) represent major global health challenges causing millions of deaths worldwide. Well integrated comprehensive strategies can contribute to overweight management. Specifically developed bioactive compounds used in food supplements can help people wanting to lose weight. Consumer are looking for safe, effective (scientifically proven), affordable and natural solutions on these issues that represent today an unmet need. Marine environment is full of biological compounds that could represent relevant answers to these needs. Especially, a specific marine carotenoid found in algae, has received a strong and recent interest from the industry as several scientific publications have demonstrated superior efficacy of this molecule in comparison of existing products targeting weight reduction. However, the only available sourcing (a macroalgae) presents several drawbacks such as the presence of micro-pollutants and some sustainability issues.
Through an innovative and patented technology, Microphyt produces sustainably and markets unique bioactive compounds extracted from the untapped diversity of microalgae. Microphyt has identified few strains which are difficult to produce in competitors systems and that are able to produce high quantities of this specific marine carotenoid. Moreover, our specific process allow the optimal production of this compound combined with PUFAs which exhibit demonstrated synergistic effects on metabolism. In this context SMILE ingredient represents a high added value potential for Microphyt. Phase 1 feasibility study aims at further analyzing IPR and regulatory status of the different strains, releasing a detailed business plan based on market feedback and pursue the scale up of the best selected strain.";71429;50000;H2020-SMEINST-1-2014;SME-1;MICROPHYT;FR;;; 196236;663157;NASTEX;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Study feasibility and best route to market for telecare solution in Germany and Japan;1/03/2015;31/08/2015;;"Navigil has launched a disruptive wearable mobile personal safefy solution into the Finnish market (http://www.navigil.com/products/s1-wearable-telecare-watch-phone/). The solution has been developed using customer requirements from market leading telecare provider (Esperi Care) who is our first customer and from similar entities in the UK.

Wearers of our wristwatch are elderly persons requiring assistance in order to live independently at home and persons suffering from dementia. Users of our location and reachability / call routing services are individual caregivers and municipal/professional telecare providers.

The lack of care resources for elderly care and for dementia sufferers is an acute issue in all EU countries. The Navigil solution addresses this particular issue by enabling persons to live safely at home longer. If the move of a person to sheltered care housing can be delayed by three days the Navigil solution saves costs. Similarly if the recuperation time in hospital after a fall can be shortened by one day our solution saves costs.

NAvigil STudy on EXpansion (NASTEX) is a project to validate our solution's fit to the German and Japanese markets and to build a market engagement plan for each market found viable.

The outcome of the study is validated eligible market size, definition of the optimum route to market and list of verified customer requirements. The best route to market study includes alternative routes for each key segment. The customer requirements verification includes collection of key customer requirements in a given market and their comparison to those found in the EU. The R&D impact of new or different customer requirements is one element of market viability and profitability calculation.

The NASTEX project is critical for our expansion plans, without it the profitability of a new market can't be reliably verified. Failure to do the verification could impair expansion efforts in the EU markets.";71429;50000;H2020-SMEINST-1-2014;SME-1;NAVIGIL OY;FI;;; 196198;662736;Pre2Pos;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;PREcession-based drive mechanisms for high-PREcision energy-efficient POSitioning devices (Pre2Pos);1/03/2015;31/08/2015;;"The objective of the project is to carry out a feasibility study (including a business plan) concerned with the application of Pre2Pos motors in the Space sector.
Pre2Pos technology (precession-based actuators, Pre2Pos in the following) allows the development of a typology of drive mechanisms that overcomes the performance of the existing technical solutions in several sectors. In particular, due to the high torque/mass ratio, the high accuracy and energy efficiency, together with the propensity to be miniaturized, these devices could bring unseen advantages to Space sector through the development of a new generation of positioning systems. In some cases, these positioning systems could substitute pneumatic and hydraulic actuators and the corresponding infrastructure plants.
The feasible study is asked to deliver a business plan aimed at quantifying the conditions for the penetration in Space market and elaborating a strategy to introduce Pre2Pos solutions in some fundamental Space applications like:

Lens positioning in optical devices
Small robotic arms
Solar panel orientation (the most promising)
Antennas orientation

The feasibility study is also aimed at integrating the above-mentioned preliminary applications by scanning the needs of Space sector related to positioning systems and translating the performance requirements in specification for Pre2Pos solutions.
The final business plan will identify the potential Pre2Pos customers, the specific market needs and the partnerships that could provide the commercial channels for a profitable economic exploitation. The market analysis will identify the most important competitors, the size and the revenue expectation. The business plan will have to suggest how much Space sector is an opportunity to be addressed and which are the strategic key points able to maximize the success rate.";71429;50000;H2020-SMEINST-1-2014;SME-1;PHI DRIVE SRL;IT;;; 196254;663466;Wavepiston;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Low price wave energy conversion through force cancellation.;1/02/2015;31/05/2015;;"No attempt to harvest energy from waves has resulted in an economically viable and competitive technology. Many projects stopped and investors have become sceptical of wave power. Currently the cost per watt of usable wave energy is high, due to a focus on energy conversion methods and efficiency, rather than on mooring and grid connection, accounting for more than 90% expenditure.
Wavepiston is a break through near-shore wave power technology producing energy from waves at a competitive price with respect to the most efficient renewable energy technologies. The system consists of identical modules mounted on a string pumping pressurized water to shore for successive energy conversion. Using Wavepistons patented force cancellation principle the system is able to reduce the amount of forces on the mooring and structure to 1:10, requiring a simpler structure and therefore reducing capital costs. The Wavepiston system can provide cost efficient, clean and reliable renewable energy to help meet Europes increasing demand and achieve emissions reduction targets. The offshore application ensures it is a suitable fit also for remote islands and isolated coastal communities.
The Wavepiston system was conceived in 2006 and in 2009 the concept of force cancellation was patented. In 2010 numerous tank tests were performed with a system 1:30 the size, that experimentally validated the system and proved each panel can harvest more than 5% of the energy contained in a wave. In 2013 a proof of concept was carried out offshore with a system 1:9 the size and it worked better than predicted. Vryhof Anchors and Nurmi Cylinders, specialised in offshore mooring and hydraulic pumps respectively, have joined the project to support product industrialization.
Phase 1 will assess various business models (with the support of the ESCO company EnerMed partner in the project), establish a complete supply chain and plan all activities for the large scale pilot to be held in Ireland.";71429;50000;H2020-SMEINST-1-2014;SME-1;WAVEPISTON A/S;DK;"ENERGIA MEDITERRANEA SRL;VRYHOF ANCHORS BV;NURMI CYLINDERS OY";"IT;NL;FI"; 196222;663039;QUIST;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Quick Sepsis Test;1/01/2015;30/06/2015;;"In QUIST, a protein will be validated as a biomarker for early detection and prognosis of sepsis in combination with several other surrogate sepsis biomarkers. Specific objective is:
To perform a feasibility study in order to gain better insight in the risks and potential hurdles for the validation study in Phase 2 and future exploitation of the projects results. This study will contain technical, commercial and economical issues.

Expected outcomes:
A solid businessplan as a result of the feasibility study. This businessplan will contain information that is currently incomplete or lacking about the market (identification of potential customers, competitors, distributors and competing technologies), regulations and industrial partners for the commercial development of a POCT for sepsis. Based on this information, also a strategy will be defined for IP management.
A research plan for the validation study, addressing technical hurdles defined in the feasibility study.";71429;50000;H2020-SMEINST-1-2014;SME-1;ABUNDNZ BV;NL;;; 196212;662898;Platon;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;software PLATform fOr iNteroperable multiphysics digital mock-up;1/02/2015;31/07/2015;;Simulation tools for virtual dynamic mock-ups are more and more adopted by product engineers because they produce essential engineering insights, avoiding significant time and cost investments. Nevertheless, the different modules of the PLM flow do not communicate each other and existing studios suffer from a non-integrated approach. Going cheaper and faster will require new technical offers and business models. Platon will solve these issues by bringing a disruptive approach at the international level. It will provide an interoperable single environment to applications which will share the same digital mock-up, allowing easier product analysis and optimization. Customers will be able to target 0 costly prototype and to increase engineers productivity. Indeed, Platon will enable users to 1) automate many repetitive design and modelling tasks, 2) evaluate the impact of design changes, 3) deploy best practices to non-experts and 4) partner with design & engineering colleagues more effectively. Phase 1 will investigate identified bottlenecks and allow a deeper market analysis. The results will be delivered in updated business plan, leading the solution to the market with clear, measurable, realistic and achievable objectives. Optis strategy is based on a win-win approach with stronger ROI for the entire ecosystem. Optis is structured with international subsidiaries and has delivered more than 7000 licenses worldwide. PLATON already owns its dedicated distribution network and a wide base of clients. Platon will enable Optis to move from a technology provider position to a solution provider status while other editors proposing complementary approaches will become natural partners through a specific platform agreement.;71429;50000;H2020-SMEINST-1-2014;SME-1;OPTIS;FR;;; 196339;664782;VANGUARD;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Versatile optomechANical GRaphene Device for bio-tissue engineering;1/04/2015;30/09/2016;;"Tissue and organ failure, caused by injury or other type of damage, accounts for a large part of the health care costs in EU and U.S. Current surgical or grafting procedures are only partly successful in restoring the functions of the damaged tissues.Tissue Engineering has emerged as a rapidly expanding field for repair and regeneration of damaged tissue and organs.This involves the seeding and attachment of human cells onto a scaffold through in-vitro, or a combination of in-vitro and in-vivo. Existing scaffold fabrication techniques are time consuming and costly.
We plan to take the first steps towards the commercialization of a novel system to fabricate tissue scaffolds made of Graphene Oxide (GO) in an extremely dynamical and efficient manner. The prototype consists of opto-mechanical and laser components that will be used to dynamically deform the initially flat surface consisting of a single layer of GO deposited over a porous membrane. Specifically, we will utilize a Spatial Light Modulator laser and a novel software application in order to realize a pixelated surface with the desired profile. The spatial deformation will be controlled and detected with the use of Atomic Force Microscopy. Special shapes of the asperities, i.e. local surface maxima of a rough surface, enhance adhesion over the entire surface when in contact with a biological material. Analogously to known natural surfaces with hierarchical roughness, we aim to mimic this kind of effects by using Graphene thanks to its high strength and flexibility. All in all, the goal of VANGuaRD is two-fold: (1) to establish the technical feasibility of our idea by designing and building a highly versatile prototype device that includes both hardware and software components for fabricating easily reconfigurable GO-based scaffolds using only a single substrate. (2) to establish the commercialization potential of such system by means of designing a viable and scalable business model.";150000;150000;ERC-2014-PoC;ERC-POC;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 196195;662712;ADDITION;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Arthritis Differential DIagnostic validaTION;1/04/2015;30/09/2015;;"Arthritis, a group of diseases involving inflammation of joints with huge health and socio-economic impacts. Early Arthritis (EA) describes newly diagnosed arthritis (incidence 2/1000). An improved arthritis management requires to enhance the EA differential diagnostic efficacy and the adequacy of the therapeutic strategies. The earlier arthritis is addressed, the more likely its progression will be limited. A mistake in differential diagnostic leads to inappropriate treatments, resulting in useless expenses and serious side effects, unjustified. Current diagnostic techniques are unsatisfactory and the most used first line treatment, Methotrexate (MTX), is ineffective in about 40% of the patients. RheumaKit is a solution for clinicians for the early differential diagnostic of patients suffering from undifferentiated arthritis (UA, a subclass of EA). RheumaKit is based on a trancriptomic signature of about 100 genes complemented by 3 clinical factors. It provides a 90% accuracy for the Rheumatoid Arthritis (RA) vs non-RA distinction, far above the ACR/EULAR2010 criterion on the same patients. It also provides probabilities for Osteoarthritis and Seronegative Spondylarthropaties. The solution consists of a synovial biopsy collection and transportation kit (CE-marked May 2014), a central lab PCR procedure, and a web application computing the effective diagnostic on a cloud-computing infrastructure. Functional, technical, logistics aspects of RheumaKit have been validated. ADDITION aims at clinically validate on a larger patient cohort the existing RheumaKit signature for the differential diagnostic of most EA patients and validate the use of the existing RheumaKit signature as a tool to predict MTX response.
ADDITION phase 2 will involve a prospective study on 500 to 1000 EA patients. The main phase 1 objectives are a feasibility study of the clinical and market aspects of ADDITION. The expected annual turnover is above 140M-280M in EU within a few years.";71429;50000;H2020-SMEINST-1-2014;SME-1;DNALYTICS;BE;;; 196190;662657;St. Bernard;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;St. Bernard - Emergency EEG and auditory evoked potentials for earlier diagnostics and treatment planning of unconscious patients;1/02/2015;31/07/2015;;"An ambulance crew is dispatched to help an unconscious man lying in the street. Is he having a stroke? Is he haemorrhaging in the brain? Has he hit his head? Is he an epileptic? Should the crew start thrombolytic treatment, stabilize the patient or give benzodiazepine? What next? These decisions need to be made every minute, every day around the world by first aid response units.

Brain-related injuries and dysfunctions cause high costs to society. The earlier the patient can be diagnosed, the more optimised the treatment path is, and the treatment outcome improves. All this saves money and time in one of the most expensive treatments and rehabilitation.

Mega Electronics has developed a solution for emergency brain (EEG) monitoring and plans to develop it into a new business concept. The concept allows easy-to-use, sub-hairline emergency EEG and auditory evoked potential (AEP) recordings and continuous monitoring during the entire patient care chain from emergency scene to hospital.

The recorded EEG signals (and biomarkers extracted from them) can be visualized and monitored both locally and remotely, even during medical imaging. Previous studies have proven excellent signal quality. Future challenges lie in expanding the signal information content while maintaining ease-of-use for emergency situations and in inclusion of AEP monitoring.

The product consists of an innovative, easy-to-use electrode strip, wireless transmission module and a remote monitoring system. No equivalent solutions are in the market yet. Users are medical professionals working in ambulances, hospitals and health care centres.

Feasibility assessment (phase 1) will develop the business concept, study the benefits of AEPs in emergency medicine, plan the technical modifications needed to current products, plan the validation measurements (for phase 2) and assess the risks of the system. Mega has a dealer network of 32 companies covering all continents and can start sales right away.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEGA ELEKTRONIIKKA OY;FI;;; 196261;663526;ULISENS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Ultra Legionella Inmunoanalysis System for Early Sensing;1/02/2015;31/07/2015;;"The general objective of ULISENS project will be focused on the commercial development and further commercialization of an automatic early warning system able to detect and quantify Legionella species in water. The system integrates an innovative fast detection automatic module able to carry out in situ analysis in real-time based on information and communication technologies to minimise the time for obtaining results. ULISENS will have the following functionalities:
- Faster response time, with a time reduction of up to 99% compared with standard laboratory tests (1h vs 288h)
- Greater reliability thanks to the certified detection and enumeration technology (accuracy of detection higher than 99%)
- Lower cost, with reductions of up to 84% compared with standard laboratory tests (8 per test vs 50 per test)
- Direct sampling from users network in real-time, no technical staff needed.
- Sustainable detection biotechnology without maintenance
- No hazardous waste generation (no biological waste)
- Customizable online early warning module with internet connection to prevent users from risk.

Apart from the previous technological objectives, ULISENS has also the following specific objectives:
- To develop a business and exploitation plan, including the assessment of the cost?effectiveness and exploitation potential of the solution.
- To tackle main bottlenecks and barriers for the full commercialization of the innovative technologies, mainly related to legislative and regulatory aspects in each country.
- To widely disseminate project outcomes to stakeholders and end?users, strengthening synergies with other initiatives and platforms to reach the maximum impact.
- To analyse market and business strategies in the sector in order to find the best combination of external agents and international entities to develop cooperation strategies for market exploitation and further products commercialization.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOTICA BIOQUIMICA ANALITICA SL;ES;;; 196221;663018;CSAR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Ensuring pipeline integrity using Earth Observation Data;1/03/2015;31/08/2015;;"Third Party Interferences (TPIs) are responsible for a large part of all failures in transmission pipelines. Examples of TPIs are excavations, construction activities, dredging, etc.. An efficient monitoring service for (short lived) TPIs requires high resolution data, a high revisit rate and needs to be dependable. These requirement cannot be filled by any single satellite mission alone. A feasibility study is proposed to investigate the quality of detection of TPIs when combining Sentinel-1 images at a high revisit frequency with higher resolution data acquired with a low revisit frequency.
The results of this study will be integrated in the existing Orbital Eye infrastructure for pipeline integrity monitoring. This will result in a system that is fully automatic and continuously operational, can monitor both long and short lived TPIs and has an operational cost that is considerably lower compared to existing solutions. No such system currently exists on the European market, creating a unique business opportunity.";71429;50000;H2020-SMEINST-1-2014;SME-1;SCIENCE AND TECHNOLOGY BV;NL;ORBITAL EYE BV;NL; 196183;662606;PULVERCOAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Low Curing Temperature Powder Coatings for Outdoor Applications;1/02/2015;31/05/2015;;"Our company, PULVERIT, is specialized in the developing, manufacturing and sale of thermosetting powder coating since 1973. Our extensive experience and constantly search for innovative products and new applications has enable us to be leaders in the powder coating sector in Italy. To sustain our growth we have opened over the last decade production sites in Poland (2000) and Brazil (2010), and commercial sites in Germany (2007) and Spain (2009) representing nowadays our sales outside Italy 45% of our total global business. Our main product lines comprise epoxy, epoxy-polyester, polyester and polyurethane powder coatings for general metal finishing, architectural applications, household appliances and industrial vehicles.
Worldwide demand for thermosetting powder coatings has increased over the last few decades based on their well-known characteristics such as excellent durability and finish, easy application and low environmental impact. The most important thermosetting resins in the powder coating market are epoxies and polyester, which cure between 180 and 200C depending on the combination and the cross linker used. Epoxies are preferred for their overall physical properties, while polyesters exhibit better outdoor weathering properties.";71429;50000;H2020-SMEINST-1-2014;SME-1;PULVERIT SPA;IT;;; 196239;663197;Cardiacom IMPLANT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Intelligent human diagnostic and therapy platform;1/12/2014;28/02/2015;;"In OECD countries the most frequent cause of mortality is cardiovascular diseases. Addressing this problem needs a holistic approach, where ICT-based monitoring is in the focus.

The disruptive innovation programme sets the target of performing complex mobile invasive monitoring of cardiovascular and associated diseases, of forecasting the state of the patients, supporting the therapy treatments and assessing the effectiveness of drugs on mobile information-technology-base.

The devices are miniature holter monitors built into the human body, which with their diagnostic algorithm will regularly or continuously assess and check the physiological condition of the users.

Innovation content: 7/24 monitoring, continous data processing, intelligent automated evaluation systems, lifelong mobile crisis management, optimized drug taking protocol, implants with long life.

Main ecomic benefits: higher health and life safety, higher economic efficiency as a result of the improvement in people health condition, less patient-doctor appointment, reduced cost of cardiovascular treatment, reduced number of operations.

Main target group: patients who have been/will be operated on any cardiovascular disease and people who have high risk factor.
The business model is built on the sale of appliances and on the sale of the related subscription-based info-communication service packages. According to the initial financial plan we count with a turnover of 100.000 pieces and an outstanding profit and return by the end of the fifth year after the market launch.

We plan the diffusion of the system in three steps with expanding geographical coverage. Before entering the markets we establish dealerships in the regions and develop a regional distributor and technical support system as well.

As desired achievements of the phase 1 five main parts of the Feasibility Study will be elaborated: Market Analysis Business Plan, Marketing Plan, Legal and Organisational Plan and Technological Plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;ATRACTOR KUTATASI, FEJLESZTESI ES SZOLGALTATO KFT;HU;;; 196304;664078;TrustNode;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;A Disruptive Router Platform for the Internet of Things TrustNode;1/02/2015;31/07/2015;;"The TrustNode project aims at prototyping, validation and demonstration of a disruptive routing platform in real world conditions. It will enable the design of novel routing paradigms asking for local intelligence to evaluate packet streams to serve upcoming B2B applications for the Internet of Things. Routing functionality is expected to migrate from core towards network edge in the next years.

Outcome of the project will be (1) assessment of market share and manufacturing costs (2) business plan and (3) figures achieved by a prototype against SoA.";71429;50000;H2020-SMEINST-1-2014;SME-1;INNOROUTE GMBH;DE;;; 196180;662506;RemoteControl Device;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Remote Controllable Devices;1/02/2015;31/07/2015;;"The project is to commercialize Remote Controllable Trawl doors that will support Europes environmental and economic competitiveness by:
1. Improved catch performance resulting in higher efficiency in food production.
2. Lesser discards.
3. Reduced fuel consumption of vessels.
4. Less environmental side-damage and impact to the seabed.
5. Improved accuracy in seismic survey operations.
With remote controlled spreading devices the crew doesnt need to pull trawl doors and vanes on board to change their position underwater. They will improve the performance of the fishing gear and seismic survey with a remote controllable system on the spreading device for the benefit of improved operation, greater catching ability for fishing, more economical for both operations in terms of reduced fuel consumption, less time consuming, and less environmental side damage and impact to the seabed. The convenient remote control is what we envisage as a key market application. The identified business opportunities are based on the revolutionary solution for the benefit of improved operation performance and reduced cost.
Owners of fishing vessels of 30 meters and longer are the potential customers. The worldwide market for traditional trawl doors is estimated close to 100 million yearly. The potential reachable market for our solution is estimated close to 70 million. The market for pelagic doors is approximately half of the total market, or 35 million. The market for vanes on a yearly base is evaluated close to 40 million. The solution will address both European and global markets.
The specific objective for the feasibility study is to obtain a solid analysis of the potential market for the Remote Controllable Spreading Devices, in order to design an adequate market penetration strategy and ultimately to direct new investments. Phase 2 will include a 0,3 sqm model for Flume Tank tests and 5,0 to 6,0 sqm scaled prototype of Remote Controllable Seismic Vanes.";71429;50000;H2020-SMEINST-1-2014;SME-1;POLAR TOGBUNADUR EHF;IS;;; 196175;662476;Mubic;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Mushroom and biogas production in a circular economy;1/04/2015;30/09/2015;;"Problem
Growing certain biological foods requires a substrate such as straw, wood, chicken litter, horse manure and poultry litter for organisms to grow. Producing substrate today has low energy efficiency, has as a consequence that nutrients are lost, and is labour intensive.

Solution the innovation
The innovation, a new production method for substrate, enables resources for biogas production and mushroom production to be used in a circular system that recovers energy and nutrients in an ecological and economically sustainable way.

The project
By creating a value circle between biogas production, mushroom production and energy and nutrient recovery it is possible to:
Generate high value growth media that is the basis for high value food production
Increase the feasibility of mushroom production by using a cheaper and transportable advanced substrate
Increase the feasibility of biogas production by re-entering the spent mushroom substrate back into biogas production
Increase energy efficiency from existing 50-55% to 80-85% of biomass in biogas production
Recover nutrients from biogas production
In phase 1 the purpose is to prepare the construction of test-, pilot- and demonstration plant to be built in phase 2.

Business model
Advanced Substrate Technology (AST) holds the rights to the innovation, which will be licensed to business partner Panbo, who is a leading supplier of production facilities to the mushroom industry.

Market and impact
The global mushroom market is bn10.8 and growing steady. Production in Europe is declining and rising in China due to lower labour costs. The targeted customers are new production facilities for mushrooms.
The case for mushroom production is particularly compelling. Using the Advanced Substrate Plant enables automation of the very labour intense mushroom production, resulting in a 50% reduction in production costs with a payback time of 2-3 years.";71429;50000;H2020-SMEINST-1-2014;SME-1;ADVANCED SUBSTRATE TECHNOLOGIES AS;DK;;; 196197;662730;ZombiApp;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;RESURRECT YOUR ZOMBIAPP. OR ARE YOU JUST GOING TO LET IT DIE?;1/02/2015;31/07/2015;;"The emerging game app mobile market has shown great economy potential. However, revenues are highly concentrated. At the top end of the revenue scale there are just 1.6% of developers, while 57% of app games are below the app poverty line due to two main problems:
1) Developers find difficulties for getting their new apps noticed. App developers believe that marketing is necessary for success, but small developers such as SMEs, entrepreneurs and independent developers cannot afford or take advantage of current marketing tools.
2) Obtaining user downloads is no longer enough in order to build a great business with mobile apps. The most successful game apps are free-to-play, monetising a tiny fraction of their audience via consumable in-app purchases. A recent study shows that, in average, developers invest 139 in marketing for each 100 they earn.

Thus, user attraction can be easily but costly boosted by current approaches but user retention and optimizing revenues per user to support apps with freemium strategies is still an on-going issue. BIKO intends to offer a disruptive game apps marketing tool, the ZombiApp service, with a twofold innovative approach:
1) Automated assessment of users interaction for marketing recommendations.
2) User profiling/segmentation for cross-promotion focused on user engagement, IAPs monetization strategy and user expenditure behaviour.

The service will redirect users within the network to indicated games in timely moments taking into account its monetization potential in the current app (the likelihood of these user still spending money on it) and the estimated exhaustion points of the app (when users tend to uninstall the game).

Moreover, BIKO proposes a disruptive business model based on a shared revenue approach easing the access to app promotion tools to small developers.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIKO2 2006 S.L.;ES;;; 196168;662451;SMP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;THE SUSTAINABLE MOBILITY PLANNER (SMP);1/01/2015;30/06/2015;;"The Sustainable Mobility Planner (SMP) is a specialized innovative IT software (tool) that enables environmental, financial and social impact assessments of sustainable transport initiatives taken in an urban environment. The tool integrates methods and calculations of the benefits of creating environmental zones, using low emission vehicles for urban distribution, bundling of goods, night distribution, reducing road capacity, etc. In short, all schemes, which municipalities, individually or together with the transport and logistics industry and retailers, can implement in urban areas to optimize freight activities and increase focus on sustainable freight transportation initiatives. The SMP interconnects emission calculations and small scale traffic models with visual communication in one system tool. The tool's usefulness and ease of use is ensured through constant updates with the latest available data from NTUs portfolio of projects, as well as through user-based data inputs and feedback. The business model guarantees a continuous development and upgrading of the tool, which will be based on the latest available transport and environmental data. The reliability will, compared to existing tools, set new standards, by replacing estimates with concrete and updated data, which is added to the system via the backend solution.
SMP will:
- On a continuous basis be able to monitor progress, calculate environmental improvements and assess the potential and need for new investment in the urban transport initiatives.
- Give politicians and planners the opportunity to compare environmental impacts of different transportation alternatives.
- Be a useful decision support tools with high and multifaceted functionality for transport solutions and the associated political framework.";71429;50000;H2020-SMEINST-1-2014;SME-1;NTU INTERNATIONAL AS;DK;;; 196224;663056;MultiCharge;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Feasibility Study for the Development of a PFC Harmonic FilterMissing Link for Creation of Simultaneous Multi-Point Fast Charging Stations for Electric Vehicles;1/03/2015;31/08/2015;;"Feasibility Study for the Development of a PFC Harmonic Filter
The Missing Link for Creation of Simultaneous Multi-Point Fast Charging Stations for Electric Vehicles Whilst some manufacturers offer multi-vehicle charge points, all models investigated were found to be cosmetic combinations of plural charging points capable of charging multiple vehicles operating the same charging methodology. No instances of true multi vehicle chargers (ie many types of vehicle/charging system on charge at the same time) were found.
This is due to the complexities arising around electrical harmonic interactions between vehicles under charge and the various charging methodologies. Sufficient work to define these has not been carried out and no vehicle or charger unit impact data is available over the longer term. Potential service providers face a choice between cosmetic combinations or multiple different charging stations, a costly option, low in flexibility.
The MultiCharge project will deliver a comprehensive picture of the harmonics between different vehicles and charging methodologies, before using software modelling to analyse the interactions and develop a Harmonic Filter to enable true multi-vehicle charging. MultiCharge replaces the active electronic module and multiple transformers present in most current EV chargers, with a single 3 phase 440 volt main passive unit comprising a zigzag auto transformer, harmonic filter, interphase transformer & rectifier block and distribution bus & control unit.
The project will deliver social and economic growth via increased uptake of cleaner to run, cheaper to use Electric Vehicles.
We will achieve this through delivery of an affordable re-charging system based upon market leader Carroll & Meynell's own technology, patented buck boost units and zigzag transformer to enable significant reductions in the cost of providing appropriate electricity supply to EV charging stations.";71429;50000;H2020-SMEINST-1-2014;SME-1;CARROLL & MEYNELL TRANSFORMERS LIMITED;UK;;; 196165;662420;AquaPure;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Detergent-free process for dishwashers with cleaning and disinfecting properties;1/01/2015;30/04/2015;;"Ten years ago, our innovative Israeli SME company, Aqua Solutions Ltd. was founded. Since the beginning, our CEO, Mr. Ahmed Alimi, focused all our efforts on the optimisation of laundering processes by means of cleaning and disinfecting solutions without the usage of detergent. This led us to develop a process that has a strong cleaning ability and a strong disinfecting ability consuming only three elements: electricity, water and salt.
With AquaPure our aim is to develop a detergent free process for industrial and household dishwashers. This apparatus will be integrated in the dishwashers and will be capable of reducing the energy consumption per cycle (70%), reduce water consumption (50%), and decrease each washing cycle duration (20%). The innovative technology helps significantly reduce costs per cycle (Energy: household: 200kWh/year; industrial: 330-2830kWh/year; water used: household: 780L/cycle; industrial: 1.200-75.200-40L/year ) and dramatically reduce environmental impact.";71429;50000;H2020-SMEINST-1-2014;SME-1;AQUA SOLUTIONS LTD;IL;;; 196367;665735;Bio4Med;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-DP;H2020;International Doctoral Programme in Biological Bases of Human Diseases;1/05/2015;30/04/2020;;"The major aim of Bio4Med (Biology for Medicine) programme is to provide unique, international, inter-disciplinary and inter-sectoral doctoral training for Early Stage Researchers (ESRs) in the domain of biological bases of human diseases. To achieve this goal it combines 22 leading research groups at the Nencki Institute and their scientific partners from world-class laboratories located in EU Member States, Switzerland, Ukraine, Japan, Canada and US. Research programme includes basic science PhD-projects focused on molecular basis of neurodegeneration, neurological disorders, cancer and metabolic diseases. All supervising researchers engaged in the Bio4Med are at the international forefront of biomedical research and have experience in PhD student supervision. Our programme will foster young researchers career development and employability by addressing the following objectives: (i) to offer excellent training in modern biology and endow ESRs with unique scientific knowledge, and experience in cutting-edge experimental techniques; (ii) to enhance research-oriented and transferable skills of ESRs; (iii) to promote scientific mobility via international, inter-disciplinary and inter-sectoral collaboration. The objectives of Bio4Med will be delivered through activities encompassing practical laboratory training, hands-on workshops, lectures corresponding to the theoretical aspects of doctoral projects, research-oriented generic skills courses, transferrable skills courses, progress talks and meetings. The training programme itself, focused on medically important issues, will make ESRs highly attractive to commercial enterprises, particularly in biotechnology and pharmaceutical sectors. Bio4Med programme will increase the regional, national as well as EU competitiveness by providing a new generation of visionary and innovative researchers able to transform basic science into healthcare solutions.";4604160;2302080;H2020-MSCA-COFUND-2014;MSCA-COFUND-DP;INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK;PL;;; 196182;662538;GALiVMS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Galileo based inshore-VMS for fisheries;1/04/2015;30/09/2015;;Main objective of the project is to develop Galileo based inshore VMS Vessel Monitoring System, tailored to monitor artisanal inshore fishing vessels that would enable National Fishery Authorities to monitor fishing vessels and at the same time increase fisherman security when on the sea. General concept of the project is to bring the cost of the VMS device down and bring the security of an always-ready satellite-based distress button. The approach will take advantage of Galileo SAR and PRS services and authentication. Proposed solution will consist of two main parts namely on-board terminal and land based TDS-Telematics Data Server. Our solution is beyond the state-of-the-art of existing VMS systems as there is no commercial solution for these problems on the market yet. The novelty of this project lies in the first-of-its-kind integration of SAR services coupled with the Galileo constellation advantages into a product that fits requirements for the inshore VMS. The most important innovations will be only one single device, lower cost technologies, a new compact antenna and authentication and jamming/spoofing elimination. Solution is oriented on the market, institutionally controlled by EU Fisheries Policy, which is represented by owners of a very big number of small fishing vessels. Project results will fulfil the needs of reformed EU Common Fisheries Policy and National Fishing Authorities to enable control of small fishing vessels and the needs of small fishermen to secure their safety. European value added of the project is reflected in important economic benefits, as it will have impact on efficiency of EU Common Fisheries Policy and costs and safety of artisanal fishermen with very important environmental impact on European level and wider. Feasibility study will address institutional, marketing, technical, IPR and regulatory issues, resulting in business plan, which will include projection of sales, financial projections, business indicators and ratios;71429;50000;H2020-SMEINST-1-2014;SME-1;EMA DOO - OZNACEVANJE IN SLEDLJIVOST V INDUSTRIJI IN LOGISTIKI;SI;;; 196309;664168;GY;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;GameYourself - Create a virtual 3D model of a persons face based on a short video taken with any smartphone cam.;1/10/2014;31/03/2015;;"GameYourself is a High-Tech Spin-Off company of the Humboldt University of Berlin specialized in the field of computer vision. The company developed a novel technology for 3D face reconstruction and face representation by combining and further developing the latest results of Prof. Peter Eiserts research group. The developed method relies on image-based systems for context and information acquisition and it significantly outperforms the current state of the art solutions.
Our automated method is capable of creating a virtual 3D model of a persons face based on a (a) short video of it taken by a regular smartphone. With our method we made it possible for the first time to create a highly realistic 3D model of a real face based on a video recorded by a regular smartphone. The result is available within a couple of minutes without manual editing.
Video game players usually spend hours a day in a game and are willing to pay for virtual tools and items. Individualizing their character (changing hair, clothes, colors etc.) plays a very important role, especially in social online games like Second Life. From the industry point of view one of the most important factors which contributes to the overall success of a particular game is the amount of the average time the users spend playing it. Hence it is in the interest of the game companies to engage their users more in their games and to gain advantage over their competitors by offering a technology that brings high value to their fanbase.
The business model of GameYourself is simple: Users pay per scanned face that is integrated into a game. Furthermore the technology can be licensed to game publishers as a white label solution.
It has to be mentioned that the opportunities of the GameYourself technology are much broader: It can be used in different industries such as e.g. the cosmetic industry, personalized marketing or surgery.";71429;50000;H2020-SMEINST-1-2014;SME-1;SOTI, TAS/ZOBISCH, ERIK-MARTIN BARLAI, BALINT GBR;DE;;; 196246;663303;IVANCA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;IntraVenous ANtibiotic Compounding Automation;1/03/2015;31/08/2015;;"The aging population is driving the demand for health care services to an all-time high. This places pressure to find novel measures of producing health services more efficiently and at a lower cost.

In the sphere of hospital pharmacies, antimicrobials are a leading group of medications. The number of doses administered in EU-based hospitals alone is 330 million. In hospital use antibiotics often need to be administered through intravenous (IV) infusion. The manual compounding of IV antibiotics is very time consuming, especially if conducted in the recommended aseptic conditions. Manual compounding is, however, often conducted in non-aseptic conditions, which exposes the IV medicines to microbial contamination. Contaminated medicines are a serious risk to patients.

Hospitals have already begun to adopt automation in care provision. The currently available compounding robots are not, however, capable of rapidly producing large quantities of IV medicines. The demand levels clearly exceed their capacities.

Newico is a pharmacy and laboratory automation company with a sound client base. With the support of the IVANCA project (IntraVenous ANtibiotic Compounding Automation), the goal of Newico is to commercialize a novel, stand-alone IV antibiotic compounding system. The I.V.ICON boasts a capacity level equivalent to 5,5 ward staff. As the I.V.ICON operates in an aseptic environment the produced IV medicines have a significantly longer shelf life (up to 30 times) and their risk of microbial contamination is in the proximity of zero %. Over ten years of use, the I.V.ICON is expected to bring 2,4 Meur savings to the hospital as compared to manual ward based compounding.

The IVANCA project feasibility study is needed to conduct a more detailed market study, learn from an ongoing hospital pilot, make draft plans on arranging manufacturing, elaborate on user needs, conduct an IPR and regulation study in main target markets and make a more detailed business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;NEWICON OY;FI;;; 196150;661784;LIIT-ChR2;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural and mechanistic study of ion transport in Channelrhodopsin-2;1/04/2015;31/03/2017;;"Channelrhodopsins are type-I rhodopsin proteins found in green algae that function as sensory photoreceptors and turn into ion channels under illumination. Upon light absorbance, the retinal moiety induces a conformational change on the protein that opens a channel through which ions can pass.
Neurons expressing channelrhodopsin-2 (ChR2) can be depolarized rapidly and reversibly by illumination, hence allowing control of the activation/inactivation of neurons in specific locations of the brain. For this reason, ChR2 has been used widely in optogenetics to study neuronal circuits and disorders in the brain, and to restore light sensitivity and visual capabilities in damaged retinas. However, in contrast to closely related bacteriorhodopsins or halorhodopsins, very little is known about their structure, light cycle and mechanism of action. The current structural evidences of ChR2 is limited to 1) the 6 projection map obtained by cryo-electron microscopy that contains a mixture of light (open channel) and dark (closed channel) states; and 2) the 2.3 X-ray structure of the dark state of a ChR1/ChR2 chimera.
In the present proposal, we aim at elucidating the structure, properties and mechanism of action of the transient species of ChR2 during its photochemical cycle by means of theoretical methods and in close collaboration with the experimental biophysics groups of the host institute.
The mechanisms of ion transport and channel opening will be simulated by enhanced sampling and free energy methods. Specific quantum-mechanics/molecular-mechanics (QM/MM) force matching force field will be generated ad hoc for the retinal moiety in the ChR2 environment. The model structures generated for the closed, open, and desensitized states will be validated 1) by comparison of the QM/MM spectroscopic properties of the model with experimental observations; and 2) by comparison to electron microscopy structures using a Bayesian analysis method recently developed in the host group.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 196353;665674;2D-Ink;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Ink-Jet printed supercapacitors based on 2D nanomaterials.;1/04/2015;30/09/2016;;This proposal will determine the technical-economic viability of scaling-up ultra-thin, ink-jet printed films based on liquid-phase exfoliated single atomic layers of a range of nanomaterials. The PI has developed methods to produce in liquid nanosheets of a range of layered materials such as graphene, transition metal oxides, etc. These 2D-materials have immediate and far-reaching potential in several high-impact technological applications such as microelectronics, composites and energy harvesting and storage. 2DNanoCaps (ERC ref: 278516) has demonstrated that lab-scale ultra-thin graphene-based supercapacitor electrodes result in unusually high-power and extremely long device life-time (100% capacitance retention for 5000 charge-discharge cycles at the high power scan rate of 10,000 mV/s). This performance is an order of magnitude better than similar systems produced with conventional methods which cause materials restacking and aggregation. A following ERC PoC grant (2D-USD, Project-Number 620189) is currently focussed on up-scaling the production of thin-films deposition methods based on ultrasonic spray for the production of large-area electrodes for supercapacitors applications. In this proposal we want to explore the new concept of manufacturing conductive, robust, thin, easily assembled electrode and solid electrolytes to realize highly-flexible and all-solid-state supercapacitors by ink-jet printing. This opportunity is particularly relevant to the electronics and portable-device industry and offers the possibility to solve flammability issues, maintaining light weight, flexibility, transparency and portability. In order to do so it will be imperative to develop ink-jet printing methods and techniques. We believe our combination of unique materials and cost-effective, robust and production-scalable process of ultra- thin ink-jet printing will enable us to compete for significant global market opportunities in the energy-storage space.;149774;149774;ERC-2014-PoC;ERC-POC;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;IE;;; 196153;661818;CMSHInBeauty;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Measuring the open to closed beauty ratio in heavy-ion collisions at LHC;1/07/2015;30/06/2017;;"The goal of this proposal is to understand the behaviour of bottomonia, i.e., bound states of bottom quark pairs,
in heavy-ion collisions. The dissociation of these states is directly linked to the temperature of the quark-gluon plasma (QGP) formed in these collisions. However, additional effects not related to the QGP formation, referred to as cold nuclear matter effects, are also thought to play a role, complicating the interpretation of present data.

A new quantity is proposed to disentangle these effects and isolate the dissociation effect of the QGP: the ratio of the nuclear modification factors (a normalized comparison of heavy-ion and proton-proton collisions) of bottomonia and open beauty. This quantity is particularly powerful if measured over the entire cross section, down to low transverse momentum.

The open beauty measurement, carried out via non-prompt J/psi identification, is challenging at low transverse momentum and the project will start by a technical development aiming at reaching transverse momentum = 0 GeV/c in the heavy-ion environment. The measurements of bottomonia and open beauty will then be carried out with the high luminosity data at increased centre-of-mass energy that will be provided by LHC at the end of 2015.

The final piece of the bottomonia puzzle is the measurement of the Xb excited states, which have never been measured in heavy-ion collisions, but which give a significant feed-down contribution to the Y(1S) ground state. A feasibility study of this difficult measurement will conclude this proposal.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196289;663879;CASI;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;AN INTEGRATED AUTOMATED ECG DIAGNOSTICS PLATFORM TO IMPROVE CARDIAC SAFETY IN CLINICAL DRUG TRIALS;1/03/2015;31/08/2015;;"Vitalograph is a 50 year old company, that designs, manufactures and sells medical devices in clinical settings and clinical drug trials. This proposal focusses on the validation of a new dual-purpose 12 lead ECG diagnostics device incorporating an automated algorithm to be used in the regulatory mandated cardiac safety elements of clinical drug trials. Current solutions are expensive, introduce unnecessary analysis delays and have poor data consistency. The proposed solution can cut customer costs by 50% whilst at the same time improving Vitalographs margin from 25% to 70% as well as reducing the analysis time from several days to a few minutes. The target market has grown to be greater than 1.6Bn in 10 years with the targeted segment being one third of this. The target customers are pharmaceutical companies conducting drug trials.
The project fits well with Vitalographs product and market strategy to develop new medical devices for clinical drug trials and will increase the available market by a factor of 10. The company already operates successfully within the market having participated in over 50 trials totalling 56m in revenue since entering the market ten years ago. It has the R&D skills and bandwidth, operational capacity and commercial capability to fully exploit the resultant offering. Vitalograph has already established a market in cardiac safety in clinical trials by buying in other devices and services.
Vitalograph will work with the world-renowned Glasgow University ECG group as a 3rd party to validate their existing clinical algorithms for automated use in clinical drug trials. An IP licensing agreement is already in place and no IP issues are anticipated. The market is heavily regulated under medical device legislation in all jurisdictions (CE MDD, FDA, CSA, JPAL, CFDA etc.) but Vitalograph already has the necessary approvals, experience, regulatory knowledge and certifications to bring this product to the market.";71429;50000;H2020-SMEINST-1-2014;SME-1;VITALOGRAPH (IRELAND) LIMITED;IE;;; 196209;662868;EctoVision;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Improved machine vision for guidance of optical system for cost-effective and environmentally safe in-situ removal of ectoparasites from farmed fish;1/02/2015;31/07/2015;;Sea lice are the most damaging parasite to the salmonid farming industry in Europe, inflicting an annual loss of 300 million. Lice originating from farms also represent a grave danger to wild populations. Fish farmers use many different methods in the effort to control sea lice infestations. However, none have proved 100% effective and sustainable over time due to environmental impacts, negative consumer perception, violation of fish welfare, and not the least of which is cost. Both governmental bodies and the aquaculture sector are now asking for a sustainable solution to the huge problems resulting from sea lice infestation of both farmed and wild salmonid stocks. Optical delousing (Stingray) is a new proactive, gentle and sustainable method for controlling the amount of sea lice in net pens. Using camera vision, software and laser allow for fully automatic louse removal without posing any danger to farmed fish, other species, or surrounding environment. The project aims to develop a dedicated advanced machine vision unit, the EctoVision, to increase the field of view, depth perception and image processing speed. The unit will be made available as an upgrade that can be easily integrated with the existing Stingray platform. The aim is to create an efficient range to detect lice and treat fish that passes within 0.4-1.5 m in the proximity of the Stingray to improve the lice removal performance by a twofold. Activities in the feasibility assessment includes investigation of possible solutions for the machine vision system, mapping best available state of the art and evaluate performance balanced against cost, in addition to search for additional partners. Case studies will be performed to provide a detailed assessment of the expected economic impact using the Stingray with the EctoVision upgrade compared with competing methods. The results will be outlined in a business plan with proper risk assessment, including a preliminary product design specification.;71429;50000;H2020-SMEINST-1-2014;SME-1;STINGRAY MARINE SOLUTIONS AS;NO;;; 196231;663110;TRAINSFARE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Transport System with Artificial Intelligence for Safety and Fare Evasion;1/01/2015;31/05/2015;;"Our projects main objective is to develop a decentralized, interoperable and flexible system to reduce some operational problems at mass transport systems and to increase their safety.

One of the concerns of Mass Transportation Operators (MTO) worldwide is the significant amount of users that avoid paying (fare dodging), amount that is increasing nowadays (estimated value of 600 million/year).

In the case of rail and metro, the installation of mechanical fare gates activated with magnetic cards helps reducing fare dodging but some users take advantage of the gate closing delay (necessary for safety reasons) and pass right behind the previous user, without validating any ticket whatsoever (tailgating). There is currently no effective solution for this problem except permanent human surveillance at the gates or the frequent deployment of mass controls: a group of inspectors checks every passing user. These mass controls are cumbersome, inconvenient for the paying user and easily avoidable by the fare dodger.

HAL has developed an artificial vision system that automatically detects tailgating and allows the selective interception of the suspected wrong-doer even before they reach the platform.

The system is being developed in collaboration with a globally respected MTO active in Barcelona, FGC (Ferrocarrils de la Generalitat de Catalunya), within their Smart Train program. A pilot under regular operating environment has proven the effectiveness of the system.

With this proposal, we plan to elaborate a detailed feasibility study (Phase 1) that will possibly recommend to opt for Phase 2 funding later on, necessary for extended R&D and for a rapid worldwide dissemination of our solution.

We expect to further expand our artificial vision technology (combined with mobile technology, when convenient) to solve other safety and maintenance challenges in nowadays mass transport operations. A second natural step could well be railway signal detection and monitoring.";71429;50000;H2020-SMEINST-1-2014;SME-1;HOLDING ASSESSORIA I LIDERATGE SL;ES;;; 196167;662446;LacDetect;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;A truly-rapid, one-minute test system for the dairy industry to assess raw milk quality, detect sub-clinical mastitis and monitor udder health, reducing antibiotic usage and environmental impact;1/03/2015;31/10/2015;;Mastitis is an infection of the udder in dairy cattle. It is a major problem in the dairy industry, costing European farmers tens of millions of Euros annually. Milk somatic cell count (SCC) is used as a main indicator of mastitis, as the number of somatic cells in milk increases in response to infection in the udder. Krysium Technologies has developed and patented LacDetect an innovative, portable, economic test system allowing reliable and truly rapid detection of sub-clinical mastitis on-farm based on enumeration of SCCs via ATP-luminescence technology. This allows farm workers and veterinarians to make quick decisions on herd management and avoid significant costs associated with clinical mastitis. Furthermore, as SCC is also used as a measurement of milk quality, dairy producers base their milk pricing policy significantly on SCC values in raw milk. LacDetect will enable recording of SCCs on-site for payment purposes. LacDetect is at Technology Readiness Level 6. Initial testing has repeatedly shown results from our prototype test system compare very favourably with those from a major milk laboratory. In this Phase I project we intend to review the specification of LacDetect, to ensure that production costs are reduced and that the end-product specification meets user requirements. We will re-contact and add commercial partners for field testing and commercializing plus explore other routes to market. On completion of Phase I we intend to progress to a Phase II project during which we will carry out final product development, scale-up manufacture, validation and final customer trials prior to commercial launch of LacDetect initially in key EU markets. Completion of the overall project will deliver a one-minute, on-farm raw milk test system enabling EU farmers to detect problems in dairy cows early, enabling better antibiotic treatment decisions, improved production, reduction in costs, higher margins, better animal welfare and less environmental impact.;71429;50000;H2020-SMEINST-1-2014;SME-1;KRYSIUM TECHNOLOGIES LIMITED;UK;;; 196337;664719;HYDRER;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;A Solar-Powered Hydrolyzer;1/05/2015;31/10/2016;;We aim to determine the technical and economic viability of a novel water electrolyzer technology based in inexpensive catalysts from transition metal coordination polymers. Industrial water electrolyzers currently need the use of corrosive alkaline electrolytes or expensive noble-metal catalysts to reach reasonable efficiencies. Because of this, they cannot compete with low cost hydrogen production using fossil fuels through steam reforming. We have discovered that coordination polymers of earth-abundant metals are active water oxidation catalyst, competitive, fast and more robust than the best heterogeneous catalyst ever reported, able to reach over one million cycles working at neutral pH and ambient conditions. This suggests that our catalysts could be the basis of an efficient and affordable electrolyzer able to function using natural waters. The simplicity of operation and the inexpensive construction materials suggest that this new electrolyzer technology could have good market penetration. We expect to reach high efficiency and low costs for hydrogen production by combining this electrolyzer with a commercially available photovoltaic cell. The results will be analyzed and compared to current electrolyzers and hydrogen production technologies to further assess its viability and identify its competitive advantages. This electrolyzer technology will be protected (IP) and, if the results are positive, targeted to market.;150000;150000;ERC-2014-PoC;ERC-POC;FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA;ES;;; 196207;662853;PlotLab;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;PlotLab - Plot combines with integrated lab equipment for lean breading;1/04/2015;30/09/2015;;"In order to feed the larger, more urban and richer population, food production must increase by 70%, and annual cereal production will need to rise to about 3 billion tonnes from 2.1 billion today. However, there are limited opportunities to expand the area of agricultural land without huge detrimental impact on the natural environment. As a consequence, sustainable increase of food supply must be based on productivity improvements. Plant breeding has significantly contributed to and will continue to be a major contributor to increased food security.
The breeding and seed production process comprises many different stages. An important part is the process where varieties are selected for field tests and planted in small 10-15 m2 plots, often 10-thousind of such plots. The following step, where crop is harvested and the quality of the crops in individual plots are determined, is a resource and time consuming process. The process involves both specialised field equipment the so-called plot combines for harvesting of the plots - and subsequent lab testing of the yield and quality parameters of crop to determine the 5%-20% candidates for further field testing.
This project will bring new machinery to market which by integrating the field equipment (the plot combine) with lab equipment can shorten the time span of the breeding and seed production process, and has the potential to shorten the variety testing and selection process by a whole season. Moreover, by determining the quality parameters (water content, oil, protein, digestibility, sugar, etc.) at the time of the harvest, only the crop from fewer candidates plots needs to be packaged and handled for further processing, saving both significant labour efforts and reducing the risk of handling-related errors in the process.";71429;50000;H2020-SMEINST-1-2014;SME-1;J HALDRUP AS;DK;;; 196294;663947;SINANN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Sonar INtegrated Advanced NavigatioN;1/03/2015;31/08/2015;;SINANN will leverage the identified capability of SonarSims high-performance Computational Ocean Acoustics framework to unlock a tangible 10-15% efficiency improvement in coastal zone seabed survey operations. The resulting productivity step change could potentially double the profit margin of a typical survey vessel, an expensive capital investment costing a minimum of 10 million per annum to operate. A significant portion of operational survey time is wasted collecting redundant seabed data and correcting routine errors caused by the inherent deficiencies in traditional manual based vessel path planning and swath coverage prediction processes. SINANN enables end users to identify the optimal fit for purpose survey configuration pre-survey, predict expected seabed survey performance analytics, and execute the optimal survey strategy in the field through smart high performance computerised solutions. Target end users are blue chip survey organisations involved in National charting, offshore oil and gas, marine renewable energy, and subsea telecoms.;71429;50000;H2020-SMEINST-1-2014;SME-1;SONARSIM LTD;IE;;; 196194;662704;MeshAnalyzer;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Analysis Tool for Mesh Design of Leading Edge Design of Integrated Circuits;1/02/2015;31/07/2015;;"EDXACT (Electronic Design Automation: Extraction Analysis and Control Tools) is a software editor producing software tools that are necessary for the design of leading edge integrated circuits (IC). EDXACT is a supplier of Apple, Samsung, Huawei, Intel, AMD, TSMC and many other companies that supply the world with products containing advanced integrated circuits.

The design of circuits with several tens of millions of transistors has become a normality over the last decade. The feature sizes of leading semiconductor circuits vary from 28nm downto 10nm and are extremely small. The design automation tools proposed by the oligopoly of the major suppliers of the market are lagging behind the technical possibilities. One of the most important aspects is the clock-design, where as much as 40% of design time could be saved by switching to modern tools. More importantly, by changing to a slightly different design approach and using a mixture of a clock-tree and clock meshes, todays circuits could save energy by more than 35%. Unfortunately, no commercial tools exist today capable of analysing clock meshes correctly. Designers are limited to manual design and internal tools, which is limiting the use of this technology.

We see an important market opportunity for EDXACT by combining our existing technology with existing tools and some intelligent glue in order to create the sought-after mesh analysis tool. Being in direct competition with the leaders of the market, we intend to progressively displace the usage of the monopolistic tool for timing analysis.

Phase 1 of the project will put in place the prototype, including documentation and marketing material, finalize an official partnership with two leading IC manufacturers, and will clarify the business plan for this interesting technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;EDXACT;FR;;; 196206;662847;VisuaLook;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Novel clothing e-commerce application for reliable size assignment and realistic fitting visualization;1/02/2015;31/07/2015;;"E-commerce has become a focal point of expansion and growth for the consumer goods industry. However, clothing market still accounts for a low ratio of online sales compared to more established sectors. Online apparel retailers have a 40% return rate, the highest in e-commerce, being bad fit the main barrier for the online market and causing 75% of these returns. In addition, final buying decision for fashion shoppers relies on the possibility to visualize realistically the look and fit of the garment and this is not possible with the current available technologies.

The overall objective of TecnologasDIM with this innovation project is to introduce in the clothing e-commerce market a disruptive web-based application (VisuaLook) for reliable size assignment and realistic fitting visualization integrating advanced ICT technologies: mobile application to capture the personal avatar (3D body geometry and photorealistic visualization), web-based virtual try on software, and ICT architecture that supports the integration and communication. We expect to reach a leading position in the market, increasing rapidly the market share and sales of the company, encouraged by an innovative and competitive solution for our clients (clothing manufactures and e-retailers) and an easy and fast adoption of the end users (e-buyers), becoming a reference for clothing e-commerce.

Firstly, we will conduct a feasibility study in Phase 1 in order to assess the integration of the core technologies, the shopping experience outline, the regulatory issues and the commercialisation strategy, ending with the elaboration of a comprehensive business plan. In Phase 2 we will perform a pilot study to demonstrate VisuaLook in a real environment with the collaboration of a relevant e-retailer of the clothing sector. VisuaLook will be ready for commercialization in Phase 3.";71429;50000;H2020-SMEINST-1-2014;SME-1;TECNOLOGIAS DIM SL;ES;;; 196241;663220;Unbabel;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Unbabel: Scalable, affordable and seamless content globalization using distributed crowd-post editing;1/03/2015;30/06/2015;;Globalisation is causing a dramatic increase in the demand for translation services, but current translation solutions are unable to provide the scalability, affordability and quality required to eliminate language barriers between companies and their customers. Unbabel is developing a translation service that combines machine translation and distributed crowd post-editing as a service, powered by innovative technology and a growing community of bilinguals and professional translators. Unbabels goal is to integrate seamlessly into tools that companies already use to communicate with their customers, such as Zendesk, MailChimp, WordPress and Github. This approach will enable any company to rapidly and affordably scale their business internationally. Unbabel has already translated more than 8 million words and beta customers of the first two integrations have demonstrated impressive results. In phase 1 of this project, Unbabel aims to prioritise and allocate investments in building further integrations with internet tools such as Github, Salesforce, Wordpress, Gmail and Etsy. A market study will be performed to evaluate the economic viability of each of these integrations. In addition, Unbabel will study the User Experience design of a fully functional mobile application that enables translators to be part of the Unbabel community from anywhere in the world, creating a new source of income to bilinguals worldwide. In phase 2, Unbabel aims to dramatically improve the profitability of the translation process for both Unbabel and the Unbabel Translator Community while reducing the cost of translation for our customers. This project will have a tremendous positive impact on both customers, in quantitative terms, on market size and turnover, and translators, in qualitative terms, on income possibilities. The expected outcome will be an accurate, fast and inexpensive translation service that meets the growing translation needs of global companies in a globalised world.;71429;50000;H2020-SMEINST-1-2014;SME-1;UNBABEL, LDA;PT;;; 196357;665696;CARPE;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Compliant Actuation Robotic Platform for Flexible Endoscopy;1/07/2015;31/12/2016;;"Prof Alfred Cuschieri, the overall coordinator of ERC grant Colonic Disease Investigation by Robotic Hydro-colonoscopy (CODIR - grant agreement 268519) has recently submitted the mid-term scientific report on behalf of the two participating Universities (Dundee and Leeds), which highlights several novel IPR (intellectual property rights) issues resulting from the CODIR research, which are pertinent to robotic flexible endoscopy. One of these is based on the active tether robot (ATR) idea for the provision of snake like locomotion; i.e., instead of the locomotive power for the active colonoscope being supplied to the back of the robot via a power cable, the design is turned on its head, and replaced by a motile segmented active tether, which is itself an endoscope, and which can operate in both a gas and aqueous environment. The platform is based on a Mini Compliant Joint (MCJ), with two degree of freedoms (DoFs) using Shape Memory Alloy (SMA) wires as actuators and torsional springs, a synergistic combination which increases the energy efficiency and mechanical bandwidth performance; and at the same time, reduces heat production and stress on the SMA wires. The MJCs actuates by current-induced contraction of SMA wires, two hollow articulating rings with 2 DoFs. As the rings have intersecting axes, the two torsional springs provide roll and pitch. Such a chain of active MCJs provides sinusoidal motor-less locomotion. In essence, CARPE is a generic modular system (capable of translation into any type of flexible endoscope in current clinical use) consisting of independent segments (much like a biomimetic vertebral column), mechanics and electronics. The big advance of CARPE, when used to construct a colonoscope over the current equivalent endoscope, is that once, the end of the CARPE colonoscope is inserted through the anus, it would travel by its intrinsic snake-like locomotion to the caecum.";150000;150000;ERC-2014-PoC;ERC-POC;University of Dundee;UK;;; 196192;662683;HighPower;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;High Efficiency Distributed Power Plant;1/02/2015;31/07/2015;;"The EU is committed to lower its C02 emissions 80-95% by 2050. Current energy technologies do not enable to reach this goal. Today, in conventional power generation, electrical efficiency is around 15-45%. Convion will commercialize a small power plant for distributed power generation that reaches electrical-efficiency up to 70% (and above 90% in CHP mode).

Convions power plant is based on Solid Oxide Fuel Cells (SOFC) technology that converts hydrocarbon and hydrogen fuels like biogas, natural gas, and hydrogen to heat and power without harmful emissions. Convions SOFC power plant enables to reduce greenhouse gases by more than 40-60% compared to conventional combustion process. In addition Convions innovation increases energy security for many EU regions and improves power stability for end-users like hospitals, data centres, production units and households.

Convion is an established company at fuel cells market that combines more than 250 cumulative years of experience in SOFC systems development. Convion is dedicated to develop a state of the art exceeding SOFC stationary application in 50-300kW power range. Demand for high-efficiency power solutions is on the rise and fuel cells technology is seen as the backbone of the energy industry in the next decades. Market opportunity in Convions segment is estimated to reach over 1B by 2020.

H2020 SME-instrument is seen as a perfect match for Convions project objectives that could support the last product development phase and enable successful market introduction of the Convion SOFC power plant. In Phase-1 Convion will further develop companys business model, customer strategy and marketing plan to take advantage of Convions strong position at distributed power generation market and achieve successful product commercialisation. Manufacturability study in Phase-1 is expected to lower the technology costs and make preparations for mass production.";71429;50000;H2020-SMEINST-1-2014;SME-1;CONVION OY;FI;;; 196279;663746;BrainWorkloadReader;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Generation of a business plan for the production of a compact and reliable device able to measure in real-time the cerebral workload state of high responsibility operators in the transport domain;1/01/2015;31/05/2015;;"The present proposal aims to generate a business plan related to the realization and commercialization of an already developed prototype able to track in real-time the cerebral workload of aircraft pilots or other operators in the transport domain. Such operators could be for instance the Air Traffic Controllers (ATCos) or those devoted to control the traffic of an high speed train network or subway. The developed device, named BrainWorkloadReader (BWR) will be used:
i) during training-assessment programs, to quantify the progress of the learners in terms of amount of cognitive resources requested during simulated or real tasks;
ii) during the normal daily activities of an operator in order to monitor in real time his/her cerebral workload for traffic control of airplanes, trains or cars in specialized control rooms.
The BWR device consists in a easy wearable cap with 6-8 electrodes connected in a wireless way to a portable recording systems. The already developed prototype has the size of a smartphone and it is able to return information about the level of cognitive workload of the operator (e.g pilots, ATCos etc etc).
The BWR device has no counterpart actually in the market, and its role will be not limited to the transport domain but it is potentially applicable in every situation in the close future in which there will be an operator and a task to be performed. This means that it will be possible to measure the level of cerebral effort across different contexts, including operators in remote surveillance tasks, etc. etc.
Possible applications will be in any environment in which a human has to monitor a system or a process and in which the occurrence of an error due to the excessive operators workload could have significant consequences for the safety of both the operators and other human subjects.";71429;50000;H2020-SMEINST-1-2014;SME-1;BRAINSIGNS SRL;IT;;; 196179;662499;ITECCO;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Innovative Transport Equipment for Coal, Coke and Ore;1/02/2015;31/07/2015;;The raw material supply of the steel industry is currently carried out with old-fashioned special wagons overaged, inflexible and in desperate need for modernization and cost-efficient replacements. Taking this initial situation into account Innofreight developed the multipurpose ultra-light container waggon, the InnoWaggon and a special container for the transportation of iron ore, the RockTainer. Together with the already well-established WoodTainer (for coal, coke and other light bulk goods) the InnoWaggon and the RockTainer provide all features for innovation. Advantages of the Innofreight-system range from lower acquisition costs, lower tare weight and higher payload to higher utilization rates, faster handling processes and lower costs of operation. The higher utilization rate results mainly from the facts that the waggon provides compatibility with all standard-sized containers and can be used in all markets. At the borders, where different railway gauges converge, the manipulation of the containers does not result in any problem as the containers can be reloaded quickly between trains and therefore facilitate the trans-European railway traffic. Already market leader and technological leader in the supply of the paper industry regarding woodchips, Innofreight strives to achieve the same position in the steel industry a market three times larger. Therefore Innofreight plans to conduct a feasibility study in order to figure out an optimal way to conquer the market for railway equipment regarding raw material supply with special focus on the steel industry. This feasibility study will cover an investment plan, subsidies, ICT infrastructure, HR and marketing efforts. Furthermore a new organizational company structure and the required financing strategy will be analysed. The final result will be a business plan including a schedule of capturing different European regions, a plan for demonstration projects and an investment as well as a budget plan.;71429;50000;H2020-SMEINST-1-2014;SME-1;INNOFREIGHT Speditions GmbH;AT;;; 196138;661656;DUALgRENP;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A DUAL gRNA system for functional assessment of ENhancers in Pluripotency;1/01/2016;31/12/2017;;Enhancers are cis-regulatory genomic regions that can modulate gene expression in a cell type-specific and time-controlled manner to regulate cellular behaviour. ChIP-seq and RNA-seq technologies have allowed genome-wide identification of potential enhancers based on the correlation among specific chromatin marks, transcription factor biding sites and gene expression. However, strategies to validate their function are still limited. Recently, it has been demonstrated that the CRISPR/Cas9 genome editing technology can be used to delete large genomic regions at high frequency by co-transfection of two guide RNAs (gRNAs) targeting collinear genomic sites and subsequent NHEJ-mediated repair. Nevertheless, this system is limited to individual tests. Here we aim to generate a novel lentiviral dual-gRNA expression system that enables large scale functional enhancer screening. The candidate will apply this dual-gRNA expression system to generate custom libraries that will allow the functional identification and subsequent validation of essential enhancers for the maintenance of mouse Embryonic Stem (mES) cell identity. This technology will provide a comprehensive view of the function of enhancers within their genomic context and will enable for the first time the performance of systematic, genetic forward enhancer screens.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 196274;663676;SCATMET;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Developing a multispectral volume scattering meter for measuring the optical properties of sea andocean water;1/02/2015;31/07/2015;;"The objective of the proposed project is to devise a new type of spectrometer for measuring the volume scattering function (VSF) in aquatic environments initially in seas and oceans, but later also in other bodies of water. As the VSF is a fundamental inherent optical property of the aquatic environment, the proposed novel tool will be of interest to virtually all private and public organisations that gather, analyse and make use of information related to sea and ocean environments.The fields of climatology, marine research and optical communication and their various sub-sectors can be outlined as key groups benefitting from such a tool.

In line with the blue growth agenda, the proposed project substantiates the idea that seas and oceans hold a remarkable potential for innovation and both economic and social benefits in the EU and globally. The project addresses a significant market gap in terms of tools enabling to realize this potential and introduces a new multispectral volume scattering meter that allows obtaining more accurate information about marine and ocean environments as well as the life that they support. The tool thereby also supports reaching a better understanding of how to use the resources available in aquatic ecosystems in a sustainable way. The proposed spectrometer has several advantages compared to its competitors, allowing measuring the VSF more precisely in a wider range of angles and providing invaluable high-quality measurement data relevant for a large number of application areas. The economic advantages for end-users are primarily associated with getting more comprehensive, precise and accurate information with less time and resources.

The Phase I project is used to verify the technological and economic viability of the proposed device and to prepare a sound plan for implementation of the innovation project, to be able to launch the product to the market in ca two years (after the successful completion of the Phase II project).";71429;50000;H2020-SMEINST-1-2014;SME-1;INTERSPECTRUM OU;EE;;; 196226;663062;MIRCAB;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Validation of diagnostic and/or prognostic miRNAs in triple-negative breast cancer;1/01/2015;30/06/2015;;"Multiplicom will draft a business plan that is composed of the following parts:
(i) selection of miRNAs for which there is substantial scientific evidence that such may be important for the diagnosis, treatment and/or prognosis of triple-negative breast cancer (TNBC) patients;
(ii) perform a thorough analysis of the intellectual property on the selected miRNAs;
(iii) start in-licensing negotiations with licensors regarding relevant intellectual property
(iv) select a suitable quantitative multiplex miRNA analysis;
(v) plan a European-wide, multi-center, clinical validation of the selected miRNAs using the selected multiplex quantification method (Validation Study); and
(vi) perform a marketing study regarding the use of miRNA diagnosis/prognosis in TNBC patients;
(vii) develop a competitive strategy.

For part (i) Multiplicom has the support of top-notch clinical scientists (KOLs) in the field of miRNA in TNBC. Multiplicom will rely on its internal expertise, and expertise of its consultants to perform (ii) to (vi). This is supported by its track record of developing and commercializing novel highly multiplexed diagnostics (ISO 13485 & CE/IVD).

The global 170,000 cases of TNBC (new cases in 2012) constitute the target patient population to be monitored by the validated multiplex miRNA test kit (Kit) such that they can be offered the best treatment of what is a multi-billion Euro pharmaceutical opportunity. From presently available data Multiplicom estimates the annual peak sales of the Kit in excess of 5M, with a gross margin of >80%, allowing further expansion of the company including new hires in all departments.";71429;50000;H2020-SMEINST-1-2014;SME-1;MULTIPLICOM NV;BE;;; 196343;664931;AstroFIt2;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-FP;H2020;Astronomy Fellowships in Italy 2;1/09/2015;31/08/2020;;"INAF, the Italian National Institute for Astrophysics is proposing AstroFIt-2 in order to support transnational brain circulation of young researchers, by means of 18 Incoming Mobility 3-year fellowships to be issued in two calls, each of 9 fellows, to be carried out at the 17 INAF Research Centers across Italy.
INAF, the Italian governments public research body that promotes, performs and coordinates astrophysics research, also cooperates with universities and other national and international entities, and has approximately 1000 permanent staff, and more than 500 contractual scientific posts. INAF is internationally renowned for its excellent science and technology, and has prime responsibility in many international astrophysical programs. AstroFIt-2 thus gives young researchers experience, through working with international teams in highly relevant, world-class scientific and technological astrophysics projects.
AstroFIt-2 builds on the success and experience acquired by INAFs AstroFIt Cofund program, and so dramatically increases the quality and quantity of AstroFIt results in the following areas:
international mobility and brain circulation: by increasing the length (3 years vs 2) and number (18 vs 14) of fellowships;
efficiency, financial support, and user-friendliness of the program by:
- increasing: a) the time for awarded fellows to reply to communications (45 days vs 15); b) the time between a fellowship being awarded and its start date (6 months vs 4); c) the living allowance (45.000 EUR/year vs 40.000) and the contribution to research and training expenses (6.000 EUR/year vs 5.000)
- shortening: the evaluation process (4 months vs. 5);
inter-disciplinary and inter-sectorial research of the fellows by:
- enhancing interactions and feedback between fellows and the Hosting Structure;
- increasing the impact of the overall program in terms of scientific activity, transnational collaborations and inter-disciplinary experience.";3823200;1911600;H2020-MSCA-COFUND-2014;MSCA-COFUND-FP;ISTITUTO NAZIONALE DI ASTROFISICA;IT;;; 196191;662659;Tunnelsafe2020;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Road and rail tunnel fire protection;1/03/2015;31/05/2015;;"Fire in tunnels is a worldwide problem that leads to disasters with infrastructural challenges and huge economic and human losses as a result. In spite of all efforts to control and prevent human errors, and to detect technical problems, accidents will occur, and without efficient fire extinguishing capability, some of these accidents will develop into catastrophes. The amount of smoke and the extreme temperatures developed in tunnel fires prohibits fire fighters and rescue workers to reach the burning objects to save the trapped people. Damage to the structure with subsequent closure of the tunnel often leads to challenges for infrastructure and societal costs.

Fireproofing of tunnels has been discussed for years, but a method that effectively extinguishes any fire, reduces smoke to secure safe evacuation and reduce the damage on the structure, has to this date not been applied.

Fire Eater is a specialist in a fire extinguishing solution that can extinguish fire anywhere inside an enclosure. It has proven safe and efficient in applications as airports, Off-Shore, power generation and distribution, datacentres, warehouses with mixed goods and chemicals, cable tunnels and much more. Fire Eater has developed the basic engineering solution to apply our method to tunnels. Only recently it has been possible to locate a full size tunnel available to do the required testing and demonstration.

The highly innovative element in the application is the transfer of a proven technology to an entirely new area of use: rail and road tunnels. When proven successful in full scale it will not only represent an interesting business opportunity, but also enable the creation of new standards for tunnel fire safety.

The purpose of the project is a detailed feasibility study, to plan and engineer the test programme, to define acceptance criteria with the customer, and to search for consortium partners needed to supply the complete system package needed in this market.";71429;50000;H2020-SMEINST-1-2014;SME-1;FIRE EATER AS;DK;;; 196177;662491;climote;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;climote Advanced Demand Management of Heating and Cooling;1/04/2015;30/09/2015;;"Climote is a multi-award winning remote controlled home heating hub. With Climote, you can control your home heating from anywhere using our full suite of remote services.

We want to create an advanced demand and management tool for domestic heating and cooling. This tool, based upon Climotes home heating hub, will help delivers Europes goal of a low carbon economy by allowing advanced demand management of heating and cooling to help prevent curtailment of European wind farms. Using the hub we can collect information about the households energy usage and create a profile for that household. This profile shows what energy is used for and when. We can then schedule certain regular and predictable tasks to happen automatically. By removing the need for manual control, not only do we make peoples lives more convenient, but we also remove human error from the equation, resulting in less energy wastage, Furthermore these tasks can be scheduled to take place at certain times, such as during off peak hours when the cost of energy is lower and there is excess renewable energy on the grid. This has both the advantage of reducing energy waste, and of shifting consumption to renewable sources.
Domestic homes account for about 27% of Europes total energy consumption. Of this the majority is made up of space and water heating and cooling which is responsible for over 80% of domestic household emissions. By networking the households together into a single central scheduling structure, we can significantly reduce the CO2 emissions across Europe. All this can be provided free of cost to the end users thanks to our business model which makes use of reselling energy credits.";71429;50000;H2020-SMEINST-1-2014;SME-1;CLIMOTE LIMITED;IE;;; 196216;662960;IDEAL;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;InDustrializing Elcogens Affordable and durabLe SOFC stack;1/02/2015;31/07/2015;;"'Elcogen Oy is developing a new Solid Oxide Fuel Cell (SOFC) stack for SOFC systems. Elcogen SOFC stack will provide a combination of better efficiency, longer durability, and lower cost, which none of the competing SOFC stack vendors can offer. These improvements will enable SOFC system manufacturers to compete against other energy production technologies without subsidies and/or tax benefits, and ensure truly environmentally friendly operation.
The overall objective of the business innovation project is successful commercialization of Elcogens SOFC stack by early 2017. In Phase 1 the key objective is to verify the technological feasibility and commercial viability of Elcogens SOFC stack. Deliverable from the study will be enhanced business plan. Enhancements will be achieved through customer visits and interviews, supplier visits and interviews, market study and tradeshow participation. Feasibility study will also cover commercial supply agreement negotiations with key component suppliers as well as initiating first customer evaluation tests for the stack.
Business opportunities for Elcogen Oy are based on the following key components: stack design is optimized from the beginning for mass-manufacturing using low cost raw materials; stacks lower operating temperature helps system manufacturers decrease system cost; and Elcogens innovative business model in the fuel cell industry is to take advantage of specialized manufacturers.
Elcogens proposal focuses on topic Stimulating the innovation potential of SMEs for a low carbon energy system within Horizon 2020 Work Programme / Societal Challenge 'Secure, Clean and Efficient Energy'.
The IDEAL business innovation project is core to Elcogens successful commercialization and market entry, and fits 100% to Elcogens strategy. It will support Elcogen to seize 9% market share of global CHP stack market by 2020, which equals to forecasted annual turnover of 45 MEUR.'";71429;50000;H2020-SMEINST-1-2014;SME-1;ELCOGEN OY;FI;;; 196264;663536;SPACEFIT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;SPAce-CompatiblE- Filters_in_dIelectric waveguide Technology;1/02/2015;31/07/2015;;"Satellite telecommunication systems are in continuous evolution, offering various types of interactive services. In order to provide such services in a cost effective manner, innovative and miniaturized technologies (low weight and volume) are required, allowing for increasing the density of the satellite payloads, offering new services and thus reducing the cost of the satellite missions.
SATFIT project aims to investigate the possible introduction into the space market of miniaturized and low-mass RF filters and multiplexers in L/S bands based ondielectric waveguide resonatorsusing an innovative solution for thermal compensation that will make the filters space compatible.
The SATFIT technology will lead to a drastic reduction of the resonator dimensions and weight (up to 50%) while maintain good performance with respect to existing technology (heavy waveguide and combline/coaxialfilters).The proposed devices will replace these filters in satellite transponders operating in L/S band. Preliminary market survey identified TTC&M (Telemetry Tracking Command & Monitoring)as first application and MSS(Mobile Satellite Services) and Navigation systems (Galileo, GPS) as future ones. The market segment that can be taken, replacing standard components is potentially 20% of the total market of L/S band filters for space.
According to the preliminary business plan, the entering into the space market of SATFIT products would increase the companyturnover of more than 30%. Phase 1 of the project is devoted to the study of the technical feasibility, analysis of the critical technical issues and risks, potential market survey (including the estimation of market share) and the analysis of the technical and economical requirements.Also a business and strategic plan for next project phases will be performed. RFM will make a deep analysis on possible partners and collaborations, especially for manufacturing and qualification activities foreseen for project phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;RF MICROTECH SRL;IT;;; 196307;664114;ECOFLEX;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Feasibility study of a Eco-friendly, Compact and Flexible System for Post Digital Printing Treatment of Textiles;1/03/2015;31/08/2015;;"Today, because of the large dimensions and costs of finishing machines, most printing houses cannot be equipped with a full production line and, after digital printing, they must send fabrics to third companies for finishing and for specific functionalizations. For European SMEs, this leads a general increase of production time and costs and a further threat to competitiveness against the larger and mass-production structured Far East companies. All over Europe, several digital printing SMEs located out of a textile district, are currently suffering the absence of a close, complete supply chain, and they seriously risk of closing their activities because of this scarce completeness. ECOFLEX is going to be proposed to the market of digitally printed fabrics, which is leaded by Europe with 45% total share and is expected to grow in the next years according to recent Industry surveys. Thanks to ECOFLEX, all the operations needed for the textiles finishing and functionalisation will be performed in a single, all-in-one and customized machine, available at low price and compact dimensions. The main benefits for the ECOFLEX users will be: Reduction of the initial investment of about 70%, Reduction of waste and production costs of about 30%, Reduction in the consumption of water and energy of about 30% and 50% respectively, time to market reduction, floor optimization, full control over the quality and repeatability of the final product, resources valorisation.
The ECOFLEX project will evaluate technical and market feasibility of an innovative, compact and flexible system for post digital printing treatment of textiles. The feasibility study will include: analysis of the technical scenario and enabling technologies, system conceptual design, identification of providers and key partners for system prototyping and scale-up, extensive market study including key countries, turnovers and competitive solutions, definition of suitable business model and business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;CIBITEX SRL;IT;;; 196259;663507;GroupEstate;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;GroupEstate Feasibility Study;1/02/2015;31/07/2015;;"GroupEstate is an innovative ICT business that seeks to solve a major social problem - access to affordable home ownership. It addresses this problem by providing an online platform that allows individuals to start and manage a shared property project, in which the ownership structure of a property is split between several individuals. By dividing the cost of purchasing real estate, participating individuals can more readily gain access to the property market, thereby affording them at least a portion of the benefits of home ownership.
To enable this disruptive approach to property and finance markets, GroupEstate will develop prototypes of its internet-based software product for European markets. Important milestones - such as the acquisition of beta test users, securing of banking and real estate industry partners, incubation period in a technology hub, and nomination for a major European innovation prize - have been reached.
GroupEstate will now launch a six-month feasibility study to analyse its progress, refine and expand its technology, identify key customer segments, assess and improve existing financial assumptions and market size analysis, and explore current and potential revenue channels. The feasibility study will include a review of international expansion opportunities by studying European markets according to a set of criteria, identifying potential partners, reviewing regulatory and legal environments, checking prototype product fit and localization requirements, and undertaking a cost analysis. The feasibility study will be prepared concurrently alongside a detailed business plan.
GroupEstate's innovative and scalable technology product will disrupt existing markets, solve a social challenge, and generate sustainable and profitable revenues. But it also carries high risks and barriers to entry. A detailed feasibility study and business plan is needed to understand and overcome the obstacles to implementing its visionary solution.";71429;50000;H2020-SMEINST-1-2014;SME-1;GROUPESTATE UG (HAFTUNGSBESCHRANKT);DE;;; 196305;664101;EMBRYON;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;EMBRYON - Develop and commercialize a highly innovative diagnostic-imaging product, improving success rates in the Assisted Reproduction IVF sector;1/03/2015;31/08/2015;;"Infertility is a heavy social issue,experienced by nearly one in six couples during reproductive lifetime.
In Vitro Fertilization (IVF) is growing 8-10% p.a.,to 1.5 million therapy cycles and 7.5 billion dollars in 2013.
Despite stressful and costly procedures,IVF success rate is low (15-20% births/cycle),leaving big opportunities for innovation and process optimization.
EMBRYON introduces to IVF clinics and specialists a last-generation diagnostic-imaging system,favoring better outcomes through deeper,smarter analysis of clinical images.
It merges tailored image-processing software and algorithms,patented by ACS,with a high-end commercial IVF microscope.A prototype is under validation with top clinics in Italy and Switzerland,supported by Nikon Instruments (global leader in IVF microscopy).
EMBRYON improves the key success factor of any IVF procedure:the identification of 1-2 embryos with best pregnancy potential to be transferred in utero,amongst 5-10 generated in vitro.
EMBRYONs precision is double than current handcrafted approaches,favoring higher success rates.
It is safer (100% not invasive),thus simpler to certify and adopt,fully compliant with ethical regulation,easier to use (no change to lab procedures) and cheaper than similar products.
Key innovations
1. Automated deep scan of embryo shape,overcoming todays subjective and approximate observations carried by the physician
2. Proprietary algorithms for the measurement of complex morphological patterns,strong predictors of potential
Sales forecasts are 1200-1400 units (40-45 M gross revenues) by 2020 in Europe and US,favored by:
- High reactivity of the IVF sector (scientists/patients) to validated solutions improving outcomes
- Commercial partnership with a global IVF microscopy leader
In Ph1 well finalize and publish the ongoing clinical studies and make a deep market analysis for Europe-US
In Ph2 we plan CE/FDA clearance,WW extension of patents,3 trials in Europe-US,set-up of newco and sales org";71429;50000;H2020-SMEINST-1-2014;SME-1;ADVANCED COMPUTER SYSTEMS A.C.S. SPA;IT;;; 196211;662894;GWAFH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Emulsar: give the world appetite for health.;1/02/2015;31/07/2015;;"Emulsar is an innovative SME founded in 2004. Emulsar invented a breakthrough emulsion technology that allows the designing and manufacturing of disruptive innovations to revolutionize health and nutrition. Since 2012 Emulsar has produced hundreds of tons of Light oil used to bring a whole new generation of ultra low-fat and healthier dressings with enhanced taste on the market.

The combination of aging populations, more sedentary lifestyles and poor nutrition habits has created a huge raise in public health issues such as diabetes, obesity, Alzheimer, denutrition and cancer.

Health goes through nutrition.
Today, poor taste is one of the main criticisms heard about healthy functional food, and undoubtedly the major reason for poor consumption.

Nutrition demands taste.

Our objective and main motivation for this project proposal are to accelerate the deployment of our innovative manufacturing technology on a European & world scale by investigating functional food market opportunities.

Emulsars mission is to improve the health impact of functional food through enhanced taste.

The deployment of such a technology will lead to these outcomes:

identify the most valuables functional food products in terms of nutrition impact and business opportunity for Europe & the world
produce lab prototypes
generate market data to forecast turnover and ROI
build a strong business plan

These outcomes will also lead to the following impacts:
positively modify patient and consumer perception of functional food
dramatically increase consumption of functional food in Europe and around the world
help solving chronic diseases and face the aging of population

The objectives of phase 1 are to conduct a global market study and realize prototypes to be used as proof of concept. The success of phase 1 will lead to industrialize and commercialize our application in phase 2 and start developing new promising applications.

Emulsar: give the world appetite for health.";71429;50000;H2020-SMEINST-1-2014;SME-1;EMULSAR;FR;;; 196164;662387;INAS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Integra A/S Service provider of drones for civil use;1/03/2015;31/08/2015;;"The overall innovative project and expected outcome is a service that operates drones on behalf of civil customers in Denmark and Europe. As of today, there are many manufactures of drones and an emerging interest among civilians to use drones for commercial and research purposes. However, due to the extensive set of prevailing regulations and certificates to obtain as well as relevant training to require in order to legally and safely operate the drone, it is very intricately work and often difficult for civilians to do. In other words - the link between the suppliers and users is missing!

With more than 25 years of experience in the aviation sector, knowledge of the legislative rules and roles in aviation as an international consultancy firm, Integra A/S has the competences and capacity to successfully operate drones and thus provide the market with the missing link and solve the problem many civilians have. Introducing this service to the European market, Integra A/S is not only a first mover in an emerging business, but also provides an innovative solution that reduces the cost of collecting data remarkably.

Areas where drones can be used:
Insurance: Monitoring of damages.
Local municipalities: Monitoring of gas pipes from leaks.
Firefighting department: fast overview of the fire.
Research: Collection of data, e.g. on climate change.

These examples illustrate how drones can be used in new ways as well as reduce cost on existing solutions.

The feasibility study will set the foundation for the business plan to be developed during this project. The study will, besides assessing the potential customers and the market of suppliers, develop a financial model as well as estimate the potential income etc. A more thorough description is included in the work package description. The outcome of the feasibility study and business plan is going to be used to determine whether to submit a Phase 2 application for the SME Instrument under Horizon 2020.";71429;50000;H2020-SMEINST-1-2014;SME-1;INTEGRA CONSULT AS;DK;;; 196176;662486;MorphoVES-PoC;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Morphogenetically active blood vessels: Proof-of-Concept;1/04/2015;30/09/2016;;"'Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Within the frame of ERC Advanced Grant BIOSILICA (From gene to biomineral: Biosynthesis and application of sponge biosilica; Grant No. 268476), we unexpectedly discovered that distinct natural, biodegradable and biofunctional polymers, including biosilica and inorganic polyphosphate (anionic), are not only bio-printable but also morphogenetically active. Likewise attractive is that those biopolymers can be functionally processed by non-toxic and charged (cationic) linkers with growth/differentiation potencies. Therefore, these formulations, backbone polymers and bioactive linkers, allowed the fabrication of unprecedented Modular Small Diameter Vascular Grafts (MSDVGs)' which combine in an optimal way physical strength with physiological activity. Furthermore, the fabrication of the synthetic vessels is performed by a home-made, easy to handle, extruder device which has been developed by our group. Therefore, this new ERC-PoC project will provide small diameter (< 6 mm) blood vessel implants (incl. the fabrication device - the extruder) urgently required in clinics, with superior properties and at low-costs, at the end of the project. We are definitively convinced that, in view of their advantages, our vessels will be preferentially used for patients requiring bypass surgery. The experimental data gathered disclose that we have in hand a product with a clear biomedical application potential. Besides of their economical value, our new type of artificial blood vessel will certainly improve the quality of life and well-being of patients with cardiovascular disorders.'";149962;149962;ERC-2014-PoC;ERC-POC;UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ;DE;;; 196135;661644;FRAGMENTATION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;State Fragmentation and Sub-State Actors in Comparative Perspective: Somalia and Afghanistan;1/09/2015;31/08/2017;;"This project offers to study processes of state formation and state fragmentation by conducting extensive fieldwork and an in-depth analysis of sub-state actors in Somalia and Afghanistan. While conventional views assume that most international actors prefer building bureaucratic states, this work aims to investigate the post 9/11 shift in international engagement that consists in identifying sub-state actors with the ability to control populations. This policy-relevant agenda is in line with the need for a better understanding of state failure that was identified in the 2004 Barcelona report. The EU requires a sound strategic thinking on state-building to counter-balance the American model that has shown its limits in Iraq and Afghanistan. This project aims to explain why states remain fragmented and will identify the conditions under which sub-state actors integrate into the states institutions. It will develop a theory of sub-state authority that is capable of falsifying two dominant paradigms of state formation: state formation as a struggle against societal forces; and state formation as a bargaining process. It will test hypotheses on the nature of political order at the sub-state level and the role of the international environment in sub-state governance. In addition to generating scientific knowledge on sub-state authorities and producing high quality publications, this work will unfold an elaborate outreach strategy, which could in turn benefit the reconstruction of a viable political order in Afghanistan, Somalia, and elsewhere. The Individual Fellowship would provide the applicant with a unique opportunity to implement this innovative research agenda, improve his methodological and theoretical skills in the process, and advance his long-term career objectives. It would strengthen his integration into the European scientific community while greatly benefiting his host institution in retaining a researcher with high potential for scientific objectives.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 196201;662784;Gait Biometrics 3;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Main goal of the project is to create a prototype of the software, which will be able to identify peoplejust based on the way how they walk.;1/02/2015;31/07/2015;;The use of gait analysis in biometrics has caught attention all over the world due to many advantages over the currently used solutions for people recognition. However, an operational automated gait recognition system does not yet exist. The main goal of the project is to commercialize novel biometric solution for highly reliable identification of people based on the characteristics of their walk. The idea is based on our long-term cooperation with Professor Jiri Straus, distinguished expert in criminalistics and forensic biomechanics, who is a member of European Academy of Forensic Science and has more than 20 year experience in human gait analysis. According to the research in this area, people could be uniquely identified based on the characteristics of their walk, even if they try to cheat it. Recent studies mention very promising conclusions regarding this method and the most optimistic one estimates the recognition rate to be about 90%. Based on our internal research we have conducted in the last two years, we are fully convinced that we can reach even better results. The expected outcome of the project is fully developed product for commercial application in both governmental and business sector. It will be used in criminalistics, security departments of banks, shopping malls and other publicly accessed places where recognition of people is important from the security or from client service prospective. The competitive advantage of our solution lies in unique combination of different gait characteristics which results in recognition rate of almost 100% and simplicity of the solution which extends possibilities of places where the system can be installed. It is an industry-driven project whose outcomes will strengthen our position in computer vision technology market. The Phase 1 of the SME instrument will allow us to analyse commercial potential and technical feasibility of the solution, which we have already validated in a small scale with positive results.;71429;50000;H2020-SMEINST-1-2014;SME-1;KINALISOFT SRO;CZ;;; 196162;662362;ODORPREP;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Real Time, Automatic and Remote-activated Sampling System for industrial odor emissions compliant with the European Standard EN 13725;1/01/2015;30/04/2015;;"LabSevice is a company that provides analytical solutions in the area of environment, food industry and polymer characterization. We have already developed a prototype of OdorPrep, which will be the first automatic and remote sampling system for odor emissions in accordance with the EN 13725 Quality Air Standard. Thus the objective of this project is the full industrial development of the current OdorPrep prototype for industry uptake as part of an odor emission management and control system in accordance to legislation. That includes the development of the final product, upgrading, controls and certifications and patent protection.
Odor emissions are an environmental pollution problem in Europe, being at the top of the list of air pollution complaints . Odor emissions occur during the operation of industrial sites (livestock farms, composting sites, landfills, refineries, etc.) which are regulated under different laws in Europe such as the Environmental Protection Act in the UK, or the Federal Emmission Control Act in Germany.";71429;50000;H2020-SMEINST-1-2014;SME-1;LAB SERVICE ANALYTICA SRL;IT;;; 196292;663915;CREST;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Climate Resilient Agriculture through revolutionary Weather Forecast and Data;1/03/2015;30/06/2015;;"Ignitia has developed revolutionizing weather forecast models for the tropical region, which are used for implementing Climate Resilient Agriculture in West Africa. These disruptive innovative forecast models achieve 82% accuracy compared to 39% for existing conventional forecast models and weather service companies. Farmers with accurate and understandable weather forecasts can boost their yield with upto 50-80% and also mitigate the Climate Change Effects which are very severe in West Africa. Ignitia will further develop and demonstrate this service in a very large project together with the Nigerian Ministry of Agriculture (FMARD) involving a database of 10 million farmers.

In Phase 1 , we will work closely with FMARD and the users to do a market study for a technical requirement specification and business plan, in order to secure a successful phase 2. We will also examine if we need extra partners in Phase 2. A risk analysis will secure the measurements and method to be used in the demonstration phase in order to give valid results. An innovation strategy will be developed and the European dimension will be refined. We will investigate potential obstacles for the company's ability to be profitable in the exploitation phase in order to secure the return on investment. Overall, the pilot will evaluate the feasibility of the concept and the idea for the project and innovation. The deliverable from phase 1 is a business innovation plan 1.";71429;50000;H2020-SMEINST-1-2014;SME-1;IGNITIA AB;SE;;; 196244;663291;SixthSense;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Early diagnosis of cervical cancer through the validation of Human Papilloma Virus viral load and expression of oncogenic viral proteins E6/E7 as risk indicators;1/04/2015;30/09/2015;;Infection with certain Human Papilloma Virus (HPV) types has been demonstrated as the most important risk factor in the development of cervical dysplasia, found to be present in nearly 100% of women with cervical cancer. Currently implemented mass-screening approaches based on imaging, Pap testing and DNA testing display some relevant drawbacks in terms of specificity and sensitivity, and even when one is diagnosed with HPV, there is practically no way to determine whether this infection will regress (90% of the cases), or will turn into cancer, with obvious economic and societal consequences. Through the SixthSense Project, PathoFinder will validate a diagnostic algorithm for HPV screening able to detect the presence of oncogenic/high-risk types HPV DNA, and to measure their viral load and expression of oncogenic viral proteins E6/E7, which will be used as risk indicators for the development of cervical cancer, thus allowing to timely diagnose who will develop cancer, and initiate the treatment accordingly. The objective is to manufacture and worldwide distribute this new assay and the associated analytical device, leveraging the proprietary new generation multiplex and Real Time PCR technology for rapid detection and identification of human pathogens in clinical specimens. This result will allow women to accurately know their risk to develop cancer undergoing only one gynaecological sampling/visit for both first line and second line testing, avoiding unnecessary and excessive follow up procedures. At the same time National Healthcare Systems would reduce the costs of unnecessary follow up visits and of more invasive investigations, while gynaecologist would also be favoured in the management of patients with low grade dysplasia.;71429;50000;H2020-SMEINST-1-2014;SME-1;PATHOFINDER BV;NL;;; 196249;663406;eMediCare2;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Promoting sustainable patient treatment by an intelligent online medicine dispenser for home care use.;1/03/2015;31/08/2015;;"THE BUSINESS CONCEPT: 8% of total healthcare expenditure or about 500bn USD per year globally, can be avoided with optimized use of medicines (IMS Health). eMediCare is a online medicine dispenser for home care use that connects the person taking the medication directly to the distributor and prescriber (GP). This challenges and disrupt the current suboptimal medication delivery from nurses or pharmacies, eMedicare offers a secure and monitored logistics chain of drug delivery where the prescriber (GP) frequently adjust the dosage to the appropriate level.
THE SOLUTION:This ICT driven disruptive business model and product innovation will reduce the amount of medicines prescribed, dispensed or sold inappropriately. We base the project on a existing cloud ICT infrastructure where the intelligent online medicine dispenser eMediCare will eliminate error sources and secure that patients take medicines correctly at right time.
THE USERS: eMediCare is intended for home care use and build a strong link but at the same time disrupt the current interplay between the health-care provider, the patient and the pharma companies producing and distributing the medication.
THE PROJECT: The phase 1 of the project is devoted to establishing business model and deliver a business plan for the key market Scandinavia and UK. The phase two of the project will pilot and further refine the business model and systems engineering design of the eMediCare and create a working prototype to be implemented in test cases in the key markets.
THE MARKET: The EU market for pre packed medication, online medication distribution with the supporting ICT/telehealth solution is estimated to 2.5B bill EUR/year that will result in a 25 bill EUR/year in healthcare cost reduction.
THE EU DIMENTION: The success of this project supports the Digital Agenda Action 75: set to give Europeans secure online access to their medical health data and achieve widespread telemedicine deployment.";71429;50000;H2020-SMEINST-1-2014;SME-1;HOSPITAL ORGANISER AS;NO;;; 196123;661579;FEDMFC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;DEVELOPMENT OF A HIGH PERFORMANCE FLOWING ELECTROLYTE-DIRECT METHANOL FUEL CELL STACK THROUGH MODELING AND EXPERIMENTAL STUDIES;1/09/2015;31/08/2017;;"Flowing electrolyte-direct methanol fuel cell (FE-DMFC) is a novel energy technology in which the performance of the conventional DMFC is increased by eliminating the methanol crossover problem. There are some studies found in the literature to predict the performance of this fuel cell using one and two-dimensional single phase models. The validation of these models was done using the experimental test results for the membrane electrode assemblies (MEA) built with conventional materials. In this project, the main objective is to develop a high performance FE-DMFC stack through modeling and experimental studies. For this purpose, a three-dimensional and two-phase multiphysics model, which includes all the transport phenomena in all the layers, will be developed to predict the performance of the FE-DMFC stack accurately. To validate this model, a FE-DMFC stack based on alternative MEA materials (i.e. materials having lower cost, and higher stability and reaction kinetics) will be manufactured in-house in cooperation with the partner organization in Europe. After validating this model, the effect of significant design and operating parameters of the stack on the output parameters will be investigated; thus the parameters that increase the performance of this fuel cell mostly will be determined. This project will have have a very positive impact in Dr. Colpan's career as it will help him to develop lasting integration with his institution and increase his network in Europe. The knowledge and results gained as a result of the research conducted during this project will be shared with other researchers, scientists, and general public through several activities (e.g. conference, seminar, and papers in the journals, webpage, and visiting schools). It is expected that the results of this project will make a significant progress toward commercialization of the FE-DMFC, which in turn contributes to the economy and social prosperity of European society.";145845,6;145845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;DOKUZ EYLUL UNIVERSITESI;TR;;; 196290;663900;Multidyn;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Patented advanced low-cost multiwell cell-culture system for in-vitro physiologically relevant biomarker screening;1/02/2015;31/05/2015;;"Biomarkers in discovery are valuable tools to understand the pathobiology of a disease and the pharmacology of a target under investigation. In-vitro screen would be invaluable in identifying working hypothesis early in drug development process. Information provided by properly selected biomarkers can greatly influence a go/no go decision. The challenge is to identify relevant biomarkers early enough to implement them for such critical decisions.
In developing in-vitro assays to identify biomarkers with potential clinical application and utility, a clear understanding and determination of what that biomarker will assess must be defined. More reliable biomarker screening protocols based on allometric scaling laws are needed to be implemented in order to gain results more respondent to human physiology. The predictive power of High Content Screening techniques can be enhanced by working with primary cells or differentiated stem cells and in 3-D culture. Nevertheless, in-vitro cell cultures are still far away from the complexity of human tissues or organs.
IVTech intends to industrialize and test Multidyn, a patented advanced low-cost cell culture system made up by a 24-chambers plate complying with the multiwell standard, capable of any internal connection and flow within the cells, able to realize cheaper faster in-vitro physiologically relevant cellular systems. Multidyn will be tested for early diabetes biomarker discovery by using a developed model of liver, vascular endothelium and adipose tissues, and when equipped with the highly performing 3D scaffolds provided by the partner Scaffdex and with suitable High Content Imaging systems provided by the partner Celltool and selected scientific laboratories.
IVTech Multidyn is at TRL 6. Phase 1 project will assess the activities needed to demonstrate the product in operational environment with potential end-users, establish a large scale production and test the market.";71429;50000;H2020-SMEINST-1-2014;SME-1;IVTECH SRL;IT;"CELLTOOL GMBH;SCAFFDEX OY";"DE;FI"; 196160;662159;ReMix;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Developing a novel light-weight Ready Mixed Concrete;1/03/2015;31/08/2015;;Ordinary ready-mixed concrete is made of sand, cement, water, stone gravel and additives. Albeit aggregate gravel is chosen for its high compressive strength and relatively low cost, its use is associated with different problems. Due to its high density, any construction will require more steel reinforcement to support the weight of the heavy concrete. The different sizes and shapes as well as the inconsistent distribution of the gravel causes air and water voids, causing weak points and is responsible for crack propagation in the concrete structure. Despite technical problems, the usage of gravel is also responsible for significant amounts of quarrying, transportation costs and CO2 emissions. We have innovated and developed a novel process and a system (consisting of the GEM-TECHTM machine and GEM-SOLTM catalyst) that creates a superior foam, which does not drain off for at least 12 hours, providing sufficient time for the cement to set resulting in high compressive strengths. The geodesic structure that is created by the novel mixing screw action and the ingredients that are mixed systematically in the GEM-TECHTM machine without using any gravel or any admixtures into GEM-TECHTM ready-mixed material provide significant cost savings. The main objectives of the ReMix project is to investigate the feasibility of developing different size machines with different specifications, examine the commercial and technical risks of the process, develop strategies to meet different standard requirements and develop strategies to commerialise our unique product. The overall objective is to develop an advanced ready mixed concrete replacement material, which is at least 45% cheaper, 28% lighter, with high compressive and flexural strengths. Our main goal is to establish GEM-TECH technology as a novel replacement for the existing ready-mixed concrete ageing technology. This is a disruptive technology, which will revolutionise the ready mixed concrete market.;71429;50000;H2020-SMEINST-1-2014;SME-1;EXPERT TOOLING & AUTOMATION LIMITED;UK;AER-TECH DEVELOPMENT LIMITED;UK; 196196;662728;CFMEBR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Carbon fiber microelectrodes for human brain research and clinical applications;1/02/2015;31/07/2015;;"Kation Europe Lp. manufactures and sells carbon fiber (CF) microelectrodes for professionals in neurological sciences used to record electrochemical signals from or to pass stimulatory currents into the brain. Using novel pulling methods and advanced materials, we have managed to produce extra-long, extra-thin tapered CF electrodes prototype with sub-micrometer carbon tip that are capable of reaching deep brain structures. A thin metal shielding on the glass sheathing allows a 10-fold increase in the recording sensitivity and the device is suitable for bipolar stimulations as well. The expected outcome of the project is an ultra-micro metal coated carbon electrode and related technology applied to use in human brain.
With the human applications new ways may emerge in diagnostics and neurosurgery. We aim to bring our prototype to maturity for commercialization and aim to enter the high volume human healthcare. The great potential of the project is highly supported by our researcher background and the 10-year long experience in developing and marketing CF microelectrodes. We have previously surveyed hundreds of our customers needs. Now we are a major manufacturer of CF microelectrodes in a growing niche market and aims to penetrate the high volume human healthcare market. If succeed, we may become a decisive maker and licensor of CF microelectrodes on the global market.
In Phase1, the purpose is to model the innovation project and the first business period related to our developments, potential market channels, applied business model and pricing, utilizations and risks. Also, we will create an elaborated business plan based on a primer market research alongside with a freedom-to-operate analysis. In Phase2, we intend to finalize our innovation activities, to demonstrate all capabilities of the new products and to optimize the technology in order to reach industrial readiness for mass production and license. The expected budget of the overall project is 2 million EUR.";71429;50000;H2020-SMEINST-1-2014;SME-1;KATION EUROPA KUTATASI FEJLESZTESIES KERESKEDELMI BT;HU;;; 196149;661780;SENet;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Social and ecological networks supporting biodiversity and food security;15/01/2016;14/01/2018;;Halting biodiversity decline and ensuring food security are urgent and interconnected challenges. I will study how social and ecological structures in interaction generate tradeoffs and synergies between food security and biodiversity conservation. SENet has two aims: A) to identify ecological and socioeconomic structures that benefit or harm food security and biodiversity conservation in a rural, poor study landscape, and B) to develop an integrated network model capable of predicting such effects in similar settings worldwide. Globally, SENet will be the first research to apply (graph-theoretic) network analysis to understand synergies and tradeoffs in the food securitybiodiversity nexus. I will develop the integrated model using data from a landscape in Ethiopia, where agricultural expansion and human-wildlife conflicts are driving deforestation. SENet differs from existing approaches that concentrate on increasing agricultural output and overlook that social and ecological outcomes are interdependent and cannot be understood separately. In contrast, my method focuses on the food security of rural villages and on the factors that prompt farmers to clear or to plant forest, to change crops, to migrate elsewhere, etc., i.e., on farmers' decisions that affect both food security and biodiversity. In this context, I will use systematic network analysis to show how farmers are connected through food trade, knowledge exchange and other socioeconomic processes, but also how their crop fields are linked to forests and humanwildlife conflicts. The implementation of SENet will draw on my skills in network analysis and the hosts research excellence on the biodiversity of agricultural landscapes, including their ongoing fieldwork in my study area. This setup ensures a theoretical and empirical foundation for my network models, and a forum for communicating my results to non-academic actors in Ethiopia and Europe.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LEUPHANA UNIVERSITAT LUNEBURG;DE;;; 196313;664219;SoN3S;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Software defined Satellite Navigation Security Simulator Study;1/02/2015;31/07/2015;;"SoN3S has the ambitious aim to perform the technical and economic feasibility study of a new Software Defined Satellite Navigation Security Simulator that meets the new requirements (security, flexibility, frequent upgrade, lower cost) emerged from the market evolution, initially targeting satellite navigation security and then extending the same approach to other space assets. The global core market of satellite navigation is more than 100 billion euros, representing an extremely promising opportunity for the exploitation of this new requirements not yet satisfied by competing products.
Current satellite navigation simulators rely on costly hardware for real time generation and transmission of the signal, mainly due computational power advantages. This however drastically increases costs and complexity of the product, reduces flexibility and upgradability as well as forces costly sales and distribution strategies.
Technically, the project has the ambition to tackle the issues of producing a real time fully software simulator exploiting the computational power available in standard PCs and combined with only an low cost USB hardware (from less than 100, for the up-conversion of the signal).
Economically, the study will tackle new software oriented sales paradigm and marketing strategies with respect to the standard distribution chain in hardware simulators. This is particularly important for the security features, that will be provided with monthly updates and it is expected to follow a similar approach to daily desktop software. Software as a Service paradigm will also be investigated from the technical (bandwidth issues) and commercial point of view.
The combination of the technical and economic feasibility study will pose the basis to create e dramatic innovation in the simulation markets.";71429;50000;H2020-SMEINST-1-2014;SME-1;QASCOM SRL;IT;;; 196152;661805;Ni-CAT;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ni-CAT;1/04/2015;31/03/2017;;The Ni-CAT project aims at boosting the catalytic activity of Ni for effectuating challenging oxidation and bond formation reactions. As a key concept to achieve this goal, the metal centers will be combined with mesoionic ligands, a class of ligands that is able to transiently store and release electrons and that is thus particularly suited for assisting a coordinated metal center in effectuating electron transfer processes. This metal-ligand synergy alleviates the limitations typically encountered for bond activation processes with nickel, which often undergoes one-electron redox changes only. This concept renders catalytic transformations with this less reactive metal center energetically feasible and eventually efficient and will introduce a new paradigm in using Earth-abundant metals in homogeneous catalysis. The exploitation of intrinsic metal ligand cooperativity for electron transfer provides a compelling strategy to develop a sustainable process towards efficient CH bond activation that is not dependent on precious metals. The project provides an excellent training in one of the most topical areas of catalysis and its successful completion will greatly enhances the career profile and the research competence of the researcher, thus actively contributing to the fostering of young talents and for prospering scientific excellence in Europe.;175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;IE;;; 196161;662195;CHP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Upscaling and commercialization of a highly efficient wood pellets fired steam engine CHP for heat and power generation;1/01/2015;31/05/2015;;"Upscaling and commercialization of a highly efficient wood pellets fired steam engine CHP for heat and power generation.
The aim of this project is the upscaling and commercialization of a developed CHP (combined heat and power generating system) comprising a highly efficient wood pellets fired steam engine. The CHP power output is 50kW electrical and 175kW thermal power with 20% electrical and 90% overall efficiency based on wood pellets . We achieve these test bench proven parameters by developing a steam engine technology with a new approach. The technology readiness level is TRL7. This CHP technology has a potential energy costs saving rate of up to 84% for customers compared to natural gas heating and grid power. This high efficiency is achieved by applying steam inlet conditions in excess of 500C and 100bar. This technology is developed with the focus on costs, reliability, efficiency and mass production. The basic patent process will be finished in 2014. By applying this technology throughout the EU, the carbon dioxide production could be lowered significantly as the fuel for this technology is wood or any other solid biomass or organic waste, which is burned highly efficient within the process. As this technology has base load capability, this would be a perfect supplement for the existing renewable energy systems like photovoltaics and wind.
Also, the dependency on fossil energy like oil and gas could be lowered. As the used fuel grows everywhere in the EU, the price of energy produced by this technology will be lower. Moreover the price will be much more time stable as there are thousands of wood suppliers who make this market much more competitive than the existing fossil fuel market with the monopoly of only a few suppliers.
The aim of of the feasibility study is to investigate the market positioning and commercialization strategy of the proposed upscaled CHP in terms of size, pricing and market launch strategy followed by the SME Phase 2 project.";71429;50000;H2020-SMEINST-1-2014;SME-1;AROSS 3D GMBH;DE;;; 196120;661543;Neuronal Trafficking;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechanisms of synaptic growth and plasticity;1/03/2016;28/02/2018;;"My long-term goal is to understand the cellular and molecular mechanisms that govern synaptic growth and plasticity, and how dysfunction in these pathways contributes to disease. Neurons are the most morphologically diverse cell type whose morphology determines many functional aspects of a neuronal network. The primary shape of a neuron is established during axon and dendrite outgrowth and synapse formation, but is subject to subsequent modifications by physiological events. In response to changes in synaptic activity, neurons can alter both pre and postsynaptic elements of the synapse. Defects in synaptic morphology and in activity-dependent plasticity are a hallmark of several neurodegenerative and cognitive disorders. It is therefore critical to know the basic mechanisms by which neurons acquire their shape and change it in response to activity, and to dissect the genes that regulate these processes. To address these questions, this proposal is divided in the following aims:
1) To dissect the postsynaptic role of the Ral/exocyst pathway in synaptic growth and activity-dependent plasticity

2) To uncover novel regulators of neuronal membrane trafficking?.
My strategy is to use the relatively simple nervous system of Drosophila to uncover novel cellular and molecular mechanisms that control synaptic development and plasticity, in order to understand how membrane traffic is regulated to form and modify neuronal structures. Because 75% of all human disease genes have related sequences in Drosophila and nearly a third are predicted to have functionally equivalent counterparts, I expect that these studies in Drosophila will contribute to the dissection of the mechanisms that, when disrupted, may lead to disease. This will help identify points of intervention, therefore directing novel therapies to help curing or ameliorating the symptoms present in many neurological disorders.";160635,6;160635,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA;PT;;; 196234;663138;COLOMBUS-1;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;COmposite repair solutions for aeronautical BUSiness development Phase 1;1/01/2015;30/06/2015;;"Composites are extensively used in many industrial applications, primarily in Transport. A technological sector dealing with composite repair solutions has emerged, now expanding proportionally to the extension of composites applications. GMI is a leading SME in this sector since 25 years, developing equipment for composite manufacturing, maintenance and repair. To ensure excellence, during the last 15 years GMI has invested in participating to several EU co-funded R&D Projects, focusing on the development of innovative composite repair solutions. As a result, today GMI possesses in its portfolio innovations deriving from more than 15 R&D projects, focusing in composite repair: Advanced heating solutions for curing of complicated aircraft composite repairs, Repair application equipment, for high performance adhesive bonding and Smart patches enabling SHM of critical aircraft components. As there is a rising demand for this type of tools, both from the aeronautical and from other closely related industries (aolien, petroleum platforms, civil engineering), GMI objective is to improve its commercial position to those markets exploiting its technological excellence. Apart from direct equipment sales, a variety of related services will be additionally developed (training, studies for demanding repairs, consulting, certification support, logistics, application of advanced repairs, participation to R&D projects, etc). To this end 2 phases have been specified: Phase 1: Development of a feasibility study, to examine technological, practical and economic viability issues, resulting in a realistic business plan for growth through COmposite repair solutions for aeronautical BUSiness development: COLOMBUS-1; Phase 2: COLOMBUS-2 will be submitted to EU, including required innovation and support activities for the materialization of prepared GMI plan. A sustainable increase of yearly turnover by 20% is expected for the next 10 years, following implementation of COLOMBUS projects.";71429;50000;H2020-SMEINST-1-2014;SME-1;GMI AERO SAS;FR;;; 196298;664000;TRANSREGEN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Portable thermal fluid regeneration system for Solar Thermal Plants;1/03/2015;31/08/2015;;"The project focuses on the Concentrated Solar Power sector (CSP). A HTF (High Temperature Fluid) is a liquid used to heat transport and transfer it in a solar thermal plant. Nowadays, most of the plants (both parabolic or tower technology) use synthetic oil as the HTF, which reaches working temperatures up to 400C. However, high temperature cycles accelerate oil degradation and then impurities appear. The appearance of impurities is a problem that affects the operation and the integrity of the current CSP power plants.
Oil regeneration is a common operation in many industrial processes, however, there is no specific solution for CSP power plants that meet their efficiency and costs related needs without risking their profitability. By now, CSP power plant operators treat the oil periodically in external far regeneration plants that provide a standard fluid distillation with low efficiency and big fluid loses that represent great costs. Due to sectors current constraints to increase power plants capital investment and operation & maintenance costs new more efficient, and with more flexible management models, HTF regeneration solutions are required.
TRANSREGEN is a new high efficiency oil regeneration system that implements a compact & transportable design in order to extend fluid generation and waste management possibilities. Having successfully designed & validated TRANSREGEN technology in a relevant environment, the overall objective of this project is the demonstration of the final solution in solar thermal plants in real operating conditions.";71429;50000;H2020-SMEINST-1-2014;SME-1;INGENIERIA Y TECNICAS DE MONTAJES LOINTEK SL;ES;;; 196145;661674;RACe;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;The impact of climate change on the uptake of arsenic into rice;30/03/2016;29/03/2019;;Rice is the staple food worldwide. Unfortunately, global rice yield is already falling behind population growth. One of the reasons for this is the presence of toxic arsenic (As) in many South(-East) Asian paddy soils, which is known to decrease rice growth and productivity. The current change in Earths climate is known to cause land loss due to desertification and inundation and lower (rice) crop yields, thus, threatening the global food security. According to the highest emission scenario for greenhouse gases presented in the 5th assessment report of the IPCC, global annual temperatures could rise by more than 5C by the year 2100. How increased temperatures and CO2 concentrations affect As uptake into rice and ultimately the quality and production of rice is unknown and the main research question of this proposal. Rice will be grown in fully controlled growth chambers with elevated temperature and partial pressure of CO2, simulating the cli-mate of the year 2100. Besides determining changes in rice growth and grain yield, the amount of organic and inorganic As in the grain will be determined to assess rice quality. Furthermore, the biogeochemical pro-cesses occurring in the soil and atmosphere during climate change will be investigated and thus, will allow to understand the observed changes in rice yield and quality due to climate change. The amount and speciation of As will be quantified in the soil, plant, and atmosphere. Changes in microbial community abundance and richness will be assessed with modern pyrosequencing techniques. Functional microbial guilds of interest (iron and arsenic metabolizing bacteria) will be assessed by qPCR, pyrosequencing, and clone libraries. Overall, the knowledge obtained within the MSC-GF action on the impact of climate change on As uptake by rice will allow a better risk assessment for productivity of rice in the future and may give ideas for how to prevent a loss in rice yield and quality in a strongly climate impacted future.;239860,8;239860,8;H2020-MSCA-IF-2014;MSCA-IF-GF;EBERHARD KARLS UNIVERSITAET TUEBINGEN;DE;;; 196181;662507;GDAPIV;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Genomics Data Analysis Pipelines with Interactive Visualizations;1/02/2015;30/06/2015;;"The GDAPIV project will deliver a next generation of genomics analysis and visualization web platform GenX that will enable bioinformatics experts (IT experts supporting life scientists) to rapidly construct diverse visual interactive web applications for researchers working in the life sciences and biomedical fields (life scientists).
GenX will enable the researchers or biomedical experts to proactively control the bioinformatics data analysis and exploration steps when validating research hypotheses. It will eliminate the need for continuous involvement of bioinformatics expert in every step of data analysis procedures, thus greatly facilitating the speed and simplicity of experimental or diagnostics processes. Even more importantly, GenX project will provide the researcher with instant insight into the genome sequence data and related downstream analyses, allowing to interactively modify and test the research hypothesis and assess them in real time, as they arise. This will significantly save time and resources, and it will disrupt the approach to the life science research and related services.
With the GDAPIV project, we strive towards riding the wave of the genomics revolution exploiting the Next-Generation Sequencing opportunity and significant expansion of sequencing machine owners (biotech, clinics, pharmaceuticals, basic research, commercial sequencing facilities) all of these are potential customers, especially considering the pitfalls of existent solutions available to the commercial sector.
The purpose of GDAPIV project is:
- to create and test GenX prototype and
- to explore business models that exploit the projects commercial potential to the fullest.";71429;50000;H2020-SMEINST-1-2014;SME-1;GENIALIS D.O.O;SI;;; 196134;661642;DESSART;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Dynamic Energy System Services to Achieve Renewable Targets;1/03/2015;31/08/2015;;"There is a niche opportunity in the electricity market across Europe for the provision of additional system/balancing services, decoupled from electricity generation, resulting from the rise in renewable generation. The innovative and unique approach is the development of hybrid-powered flywheels, synergising two proven technologies, flywheels and batteries and application to the electricity system for the first time, to provide security and stability. Hybrid-powered flywheels are resounding success in Formula1 motor racing for rapid acceleration. Schwungrad Energie plans to exploit the concept to enhance system security and stability. The advanced energy storage technology market is forecast to expand at a Compound Annual Growth Rate of 12.3% to 27 billion between 2012 and 2020.
European countries are aiming to achieve low carbon energy systems by transitioning to renewable sources, to realise their European targets. This requires a higher penetration of intermittent, unpredictable generators (wind/solar). In Ireland, with high winds and relatively weak interconnection, the System Operator has proposed a new payment structure for additional system/balancing services, expanding the market. This makes Ireland an ideal location for the first hybrid-powered flywheel facility before market replication throughout Europe and worldwide as renewable penetration increases in other countries.

Schwungrad Energie, an Irish company, was set up to successfully develop, operate and roll out facilities to provide system/balancing services in the electricity sector. The key personnel have expertise and experience in the technical, commercial, managerial and financial areas needed for project success and commercialisation within EU and beyond. Some have previous involvement with successful FP7 projects such as MACCSol. Discussion with a small number of potential key international equity investors are on-going and considerable positive interest has been expressed to fund the project.";71429;50000;H2020-SMEINST-1-2014;SME-1;SCHWUNDGRAD ENERGIE LIMITED;IE;;; 196186;662638;uMonitorRare;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Empowering Rare Disease Patients: Integrated Personalized Cloud Patient Monitoring Platform;1/02/2015;30/04/2015;;"We own and run a cloud patient monitoring platform that consists of one part for healthcare professionals: uClinics and another one for patients: uPatient. uClinics allows doctors to prescribe and assess the patient and uPatient empowers patients to understand their health treatment. We want to adapt the design of these two applications through Phase I and II funding to rare diseases and call the project uMonitorRare. uClinics and uPatient are fully functional and being used by our three largest customers in over 70 countries and 5 continents.

For Phase II, the overall objective is the technical re-design and upgrade of our uClinics and uPatient suites for rare disease patients (integration of new monitoring protocols for rare diseases, integration of new devices adapted to new diseases, integration of the Platform to Health Information Systems, multi-source data aggregation, benchmarking technology). In Phase I, we need to conduct a Technical Feasibility Study and complete a Business Plan.
The uMonitorRare breakthrough ICT product will create a new market by offering an integrated rare diseases monitoring and management tool for rare disease patients. This is going to have a transformatory impact on rare disease patients who will become the universal patient at the center of attention.

According to the World Health Organization (WHO), there are nearly 7,000 rare diseases affecting 7% of world population. This means that 3 million people are affected by rare diseases throughout Spain and 30 million people are affected by rare diseases throughout Europe. Not only does this represent a major market potential, but also can it have a major impact on the way patients are treated.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEDTEP ONLINE SL;ES;;; 196308;664165;enControl-Intuo;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;ENergy-efficient CONTROL with INternet-of-Things connected home solUtiOn;1/01/2015;30/06/2015;;"We propose a connected home solution that helps reduce energy costs while preserving comfort for occupants. Our solution, enControl-Intuo, leverages the Internet-of-Things and integrates self-learning and adjusting capabilities for interacting with any climate system, from wall units to central heating and air conditioning to radiators.
As an added service to our enControl energy service platform for utilities, the innovation project integrates a proprietary algorithm to offer seamless energy efficiency to residential utility customers - saving energy and reducing their carbon footprint.
The innovation will enable new business models for European utilities: 1.-New energy services to reduce consumption and carbon footprint in homes; 2.-User engagement & customer satisfaction; 3.-Accelerate adaptation to new sources of energy.

The innovation is tailored not only to a homes consumption patterns but also to its energy supply model. It optimizes energy usage with energy availability and variable energy tariffs considering the own-energy generation when computing the optimal policy. In addition, the algorithm learns user comfort preferences reducing user interaction with the system.
Our solution allows interoperability of devices from different vendors. We address this challenge with a holistic, scalable and secure Cloud-based software that seamlessly integrates new home devices and equipment and enables users to make their home smarter and more self-sufficient in the future. The solution allows for fast scalability to reach the large and lucrative residential market. With a next-generation service and a recurring monthly revenue model that fits most household budgets, we expect our solution to quickly gain traction in early adopter segments in Europe. These elements will allow us to confidently approach venture capitalists and other outside investors who will provide the capital necessary to quickly expand to other European and global markets.";71429;50000;H2020-SMEINST-1-2014;SME-1;SENSING & CONTROL SYSTEMS SL;ES;;; 196277;663724;ScanZ;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Point of care medical device enabling patient self-assessment for acne diagnosis support.;1/02/2015;31/05/2015;;"mySkin aims to offer a medically certified skin imaging point of care device for acne diagnosis support, ScanZ. The product is available in two forms: a consumer electronic version for patients to perform a self-analysis and track the health of their skin away outside the clinic; a premium version for use by health care professionals (doctors/nurses) to speed up the assessment and support diagnosis. ScanZ is easy-to-use handheld device and connects to the users smart device enabling instant viewing and real-time info sharing between the patient and the doctor, replacing follow ups. The device also remotely connects with the data server for data of images creating a large catalogue of clinical traces, enabling big data analytics of acne.
The ScanZ tool is able to understand what is happening under the skin and take measurements, in the sebaceous glands and the various layers of the epidermis. It is self-learning and gets to know the user over time, improving its recommendations and predictions the more it is used.
For patients ScanZ means they can save time by not having to attend follow up vistis yet get the same service, and for doctors it means they can concentrate on patients with more severe problems and reduce the waiting list time.
ScanZ has reached TRL 7 and now requires funding to get it medically certified allowing it to be used by doctors support their diagnosis.
ScanZ project is proposed by a Serbian SME, mySkin, specialised on skin diagnostic tools.";71429;50000;H2020-SMEINST-1-2014;SME-1;MYSKIN DOO BEOGRAD (STARI GRAD);RS;;; 196108;661496;QSIPP;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Exploring bacterial Quorum Sensing Infochemicals and hydrolytic Proteins linked to marine Particle degradation;;;;"The ocean is by far the largest reservoir for carbon dioxide (CO2) on Earth and represents a driving force for climate mitigation. Through photosynthesis, active marine microorganisms (e.g. phytoplankton) convert atmospheric CO2 into biomass, where the majority of it is cycled in the surface waters by diverse processes including bacterial respiration and hydrolysis. Some of this biomass is exported as particulate organic carbon (POC) into the deep ocean, where bacterial cells play a critical role in regulating the efficiency of carbon export because they colonize and enzymatically hydrolyze POC as it sinks . A recent study suggested that signaling mechanisms within particle-associated bacterial communities enhance the activity of hydrolytic proteins involved in POC degradation. This overlooked process, known as quorum sensing, might impact the amount of carbon sequestered in the marine environment and ultimately affect the rate that CO2 is removed from the atmosphere.
Quorum sensing (QS) involves the excretion and reception of distinct signaling molecules, but the biogeochemical implications of these bacterial conversations are poorly understood. To date, only a few culture-independent studies on QS in the marine environment have been carried out. This project will elucidate the role of QS systems among marine bacteria in triggering the synthesis of specific infochemicals and hydrolytic proteins, as well as its impact on shaping particles and particle-associated bacterial communities. Proposed methods include mass spectrometry, proteomics, three-dimensional particle imaging, molecular assessment of bacterial assemblages, and in situ localization of bacteria on intact particles. The outcome of the project will provide critical information on the importance of QS in regulating the efficiency of POC degradation in the ocean, which is necessary to understand and predict future climate scenarios.";239860,8;239860,8;H2020-MSCA-IF-2014;MSCA-IF-GF;ALFRED-WEGENER-INSTITUT HELMHOLTZ- ZENTRUM FUER POLAR- UND MEERESFORSCHUNG;DE;;; 196229;663104;YouBeep;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;YouBeep InStore mobile shopping and analytics;1/02/2015;31/07/2015;;"This project is YouBeep, a patented new checkout system, available free to use with a smartphone, expected to change the way people do their shopping in a retail store, allowing checkout a full shopping cart in under a minute. The long queues and waiting time at checkout lines are a key factor in customer satisfactions, and effectively represent a real high cost for retailers worldwide. Our proposal addresses this issues.
Shoppers will be able to scan their items as they shop, saving time, while keeping the control over the overall amount to be paid, and their grocery list. At checkout, the shopper just needs to use their phone at any available checkout, by scanning a Qrcode.
YouBeep is supported by a hardware component (patented USB device), mobile App and a cloud solution. It allows integration in any POS systems and zero software integration. Installation is simply connecting a USB cable, and all loyalty and couponing programs are still supported.
The potential market for the product is very promising. The overall market for this product overlaps and greatly exceeds the market of self-checkout system that is growing at a rate of 15% per year. YouBeep usage data provide valuable analytics to retailers and Brands, and effectively leverages retailers, by providing top innovative retail technology, usually only available to top retailers, to more challenging retailers, at a viable cost, increasing EU competitiveness. The company has made an agreement with the major retailer in Portugal, for a public Pilot Trial at their stores.
The objectives set for the feasibility study are validation of user traction in a meaningful pilot trial at several stores, Retailer validation, and creation of a business and marketing plan, including pricing model. In addition to this we also intend to progress and make sure our project takes the necessary steps to be eligible for Phase 2 funding of SME Instruments.";71429;50000;H2020-SMEINST-1-2014;SME-1;XHOCKWARE SA;PT;;; 196146;661690;PARACORT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of macroPARAsite COinfection in Rodent-borne microparasite Transmission;22/05/2015;21/08/2016;;Rodent-borne microparasitic infectious diseases (e.g. LCMv), including those transmitted by the rodents ectoparasites (e.g. TBE), are of increasing concern for public health. Rodents themselves are also a threat to food security because they damage agricultural crops and food stores. Effective control of these emerging and re-emerging diseases (and the rodent hosts themselves) requires a full understanding of the parasite-host dynamic. This dynamic is likely to be altered where hosts are coinfected with prevalent endemic macroparasite species (e.g. helminths), which change host demography and may interact directly with microparasites via the hosts immune system. Using empirical data from a typical European temperate forest in the Autonomous Province of Trent (PAT), Northern Italy, this project will: i) first assesses which macro- and microparasites interactions exist among the common parasite community in this region (using advanced statistical methods), ii) develop a mathematical modelling framework to assess the long term dynamics of the rodent and parasite community and to simulate the outcome of a range of different parasite and host control strategies and iii) use this model to develop a co-ordinated OneHealth plan for both rodent and parasite control in PAT .;112673,25;112673,25;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDAZIONE EDMUND MACH;IT;;; 196275;663688;BRIGHT NANO-DIAMONDS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Innovative fluorescent Nanodiamonds as bright permanent markers for diagnostics and anti-counterfeiting;1/12/2014;31/05/2015;;"DiamLite is a French company devoted to the commercialization of innovative fluorescent NanoDiamonds (fNDs) as bright permanent markers for a wide range of applications, in biology and diagnostics or for marking objects (anti-counterfeiting) and fluids (probing reservoir for oil prospection).
DiamLites markers made of fNDs have key advantages over competitive solutions: their intense and indefinite fluorescence, their stability over time and in extreme conditions, their small size, their biocompatibility and the possibility to functionalise them, as well as the ability to produce them at a large-scale, and consequently to sell them at a competitive price. There is currently no commercial source of fNDs having all these exceptional properties.
DiamLite perfectly controls the production process of these fNDs. Future challenges and objectives of the BRIGHT NANODIAMONDS project through the SME Instrument call are:
1) The scale-up optimisation for large-scale production of brighter fNDs;
2) The business development for the two targeted applications.
Therefore, the SME Instrument Phase 1 will include:
1) A technical study on the identification of best parameters and conditions for a large-scale production of bright fNDs ;
2) The selection of the best partners and equipment able to carry out this production in the SME call Phase 2, as well as customer prospection with an intensification of contacts and identification of new business opportunities.
DiamLite will start co-developments to implement specific applications (for research in life sciences, diagnostics, object marking for anti-counterfeiting). Then, the company will sell fNDs for these applications.";71429;50000;H2020-SMEINST-1-2014;SME-1;DIAMLITE;FR;;; 196137;661646;CAMP-BIVALENCE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Roma, Gypsies and Travellers' social in/exclusion in European urban camps;1/09/2016;31/08/2018;;"The project aims to analyse the role of Civil Society Organisations (CSOs) in Roma, Gypsies and Travellers (RGTs) in/exclusion in European urban camps. Triangulating individual semi-structured interviews, oral histories, archival research, and interpretative policy analysis, the interdisciplinary project combines Sociological, Socio-Anthropological and Socio-Historical approaches, contemplating two UK and two Italian superdiverse urban contexts as case studies. It contributes to three research streams: housing exclusion; RGT policy, and camps as socio-spatial configurations, and inaugurates a new interdisciplinary research field on Urban Camps. Dr Sigona, who will act as the Supervisor, is a leading scholar in migration and Roma research in Europe; his expertise is particularly complementary with Dr Picker research skills and knowledge coming from ten years of Sociological field-based research on Roma spatial segregation in five European countries. Due to the excellent quality of infrastructure, scholarly research and staff, the School of Social Policy and the Institute for Research into Superdiversity at the University of Birmingham are the most appropriate academic environment for Dr Picker to become, after the Fellowship, a leading social science scholar in the European Research Area.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 196105;661482;GEOCA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Geometry and Computational Anatomy;1/03/2015;28/02/2017;;"The past decades have brought fascinating technological improvements of medical imaging techniques. This rapid development is accompanied by a growing need for computer based algorithms to align and extract markers from medical images. The days of heuristically engineered computer algorithms are, however, over; competitive, state-of-the-art medical imaging software must be based on rigorous mathematics to ensure accuracy, efficiency, and stability.

Our research project lies at the forefront of computational anatomy (CA), a truly interdisciplinary field within medical imaging, combining differential equations theory, numerical analysis, computer vision, statistical methods, and differential geometry. CA is an emerging field that harbours a wealth of challenging problems. In particular, to develop image registration algorithms capable of handling heavily nonlinear deformations. In this project we construct image registration algorithms beyond state-of-the-art, adept of tasks where today's methods are inadequate. This is achieved by combining the knowledge of Professor Stig Larsson (scientist in charge) with the knowledge of Dr Klas Modin (experienced researcher).

Larsson is a world-leading expert on numerical methods for partial differential equations. He has a large network of international collaborators as well as close connections to the medical imaging industry in Sweden.

Modin has extensive expertise on geometric integration (GI), infinite-dimensional geometry, and CA, acquired via two post-doctoral positions at top research groups in two third countries. He thus brings state-of-the-art knowledge to the European research area. In particular, Modin's mastery of large deformation diffeomorphic metric matching (LDDMM) and Euler--Arnold equations is essential; it provides the link between image registration and PDEs. This link is the basis of the new, exciting methodology in the project: to apply state-of-the-art numerical PDE techniques to image registration.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CHALMERS TEKNISKA HOEGSKOLA AB;SE;;; 196219;662990;TCN TimeAnalyzer;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;TimeAnalyzer in real-time networks;1/02/2015;31/01/2016;;"TCN TimeAnalyzer is a unique application providing worst-case (and best-case) timing predictions of a switched Ethernet network by analyzing a model of the network.

A central part in TCN TimeAnalyzer is the computational engine that implements a set of formulas that allows the computation of upper bounds on frame latency, jitter and maximum frame buffer space required in each switch. The formulas are a result of applying real-time scheduling analysis to packet forwarding in a packet switched Ethernet network. These formulas constitute a computational model which allows the prediction of how the limited speed of physical network devices and contention among different packets for the same network resources gives rise to latency, jitter, etc. for a specific packet forwarded between two nodes in the network. The computational analysis engine will incorporate models of every component used in the network and also every other entity that compete for the same network resources as the packet under observation.

TCN TimeAnalyzer builds simulation models of how different configuration parameters and packet scheduling mechanisms of certain switches will affect worst case traffic situations.

A feasibility study shall be developed verifying the technological/practical as well as economic viability of the innovation.
Activities will focus on innovation activities such as demonstration, testing, prototyping, piloting, scaling-up, design aiming to bring the product to industrial readiness and maturity for market introduction. It will also include some research to further develop the computational engine.";71429;50000;H2020-SMEINST-1-2014;SME-1;TIME-CRITICAL NETWORKS AB;SE;;; 196171;662455;CELLETEST;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Liquid Biopsy blood test in lung cancer diagnosis and monitoring: a next generation noninvasive tumor tracker device;2/02/2015;1/06/2015;;"The ultimate objective of the Celletest project is to develop a next generation medical device for non-invasive diagnosis and prognosis of metastatic lung cancer, so we can validate the . To achieve this ambitious objective, we will exploit the potential of our proprietary technology for isolation of circulating tumor cells from the bloodstream, so we can validate the clinical utility of CTCs, which have been already identified as biomarkers for the liquid-biopsy of metastatic lung cancers.
What is a Liquid Biopsy? Liquid biopsy is an emerging and disruptive technology in cancer diagnosis, prognosis and monitoring of evolution of cancer patients under anticancer therapies. This novel technology can be understood as the next generation non-invasive alternative to the current gold standard in cancer diagnosis, tissue biopsy. Tissue biopsy implies an interventional/surgical procedure to sample cells or tissue at the tumor site. The biopsied tissue is examined and analyzed (molecular characterization for the determination of the molecular biomarkers of cancer cells) in order to characterize the cancer cells according to their morphological and biochemical properties. This allows determining the tumor typology and prescribing the most optimal anticancer therapy. Liquid biopsy holds promise as a non-invasive method capable to obtain the same clinically relevant information with just a simple blood extraction.";71429;50000;H2020-SMEINST-1-2014;SME-1;STEM SEL SRL;IT;;; 196130;661621;iREACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Inkjet-Printed Wireless Powered Circuits for Sensing and Identification;11/02/2016;10/02/2019;;"The project establishes the application of inkjet printing as a key technology for the implementation of batteryless and wireless sensor and communication circuits based on wireless power transfer and energy harvesting, enabling the realization of the Internet of Things (IoT). Inkjet printing supports a large volume production, achieves a good resolution necessary for high frequency electronics, enables the use of a variety of low cost and flexible materials, and is a direct-write, and additive manufacturing technology. The research outcomes of the project focus in two goals, 1) demonstrate low profile, conformal, inkjet printed RF energy harvesters and autonomous wireless sensor and communication circuits, and 2) establish inkjet printing in millimeter wave frequencies.
The applicant will become an expert in inkjet printing during the outgoing phase at Georgia Tech ATHENA laboratory, a world leading laboratory in inkjet printed RF electronics, where he would gain hands-on training in the technology, and he will develop transferable skills related to proposal, IPR and outreach activities and a wide scientific and industrial network of contacts. The applicant will also transfer to ATHENA lab his broad experience in energy harvesting and nonlinear circuit design, and he will enable a link with European networks in the field such as EU COST IC1301 on wireless power transfer, and foster a long-term collaboration beyond the project. Upon his return, an industrial secondment is foreseen which will allow the applicant to further train on IPR, as well as familiarize himself with the process of bringing the outcomes of the project into commercial products. The applicant will participate in the Scientific coordination and lead the Microwave Systems and Nanotechnology Group of the return host, which already has the necessary facilities to support inkjet printing fabrication.";257191,2;257191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE TECNOLOGIC DE TELECOMUNICACIONS DE CATALUNYA;ES;;; 196148;661679;GENENET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gene networks to investigate lateral gene transfer in parasitic protozoa;1/10/2015;30/09/2017;;Protozoan pathogens from the kinetoplastid radiation (Leishmania, Trypanosoma) cause major diseases affecting humans, livestock and plants in the developing World and are an emerging problem in the developed world. Despite their importance for human health, these pathogens are still poorly studied with respect to the plasticity of their genomes and its importance for pathogen biology. The increasing availability of complete genomes provides opportunities to gain a better understanding of their genome content, to understand the role of gene flow in providing new pathogenic abilities and to identify how pathogens differ from their free-living relatives and from their hosts. The proposal involves a promising researcher from Paris, France, with a background in biochemistry and computer science moving to a host laboratory in Newcastle, UK, noted for excellent training of young researchers, and for its research on pathogen evolution, to undertake a multidisciplinary investigation, combining phylogenetics and network-based methods to identify how vertical and lateral/horizontal gene flow have affected the genomes and metabolism of these important pathogens. Host training in analysing pathogen genome evolution and large datasets using sophisticated Bayesian methods for statistical inference will synergistically complement the skills of the researcher in network and graph approaches, to achieve these goals. The project will equip the researcher with generally applicable expertise in computational analysis of large data sets from an evolution perspective and in their biological interpretation. It will deliver the first detailed insights into how lateral gene flow has affected the genomes of strategically chosen pathogens of the kinetoplastid radiation, and it will have general implications for understanding how all eukaryotic genomes, including our own, have evolved and continue to evolve.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 196283;663792;GroundCLeaner;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Fast and cost-effective combined remediation technology for the elimination of chlorinated and otherhydrocarbons from soil;1/01/2015;31/03/2015;;"The business of our company, IEG Technologie GmbH is soil remediation by using our groundwater circulation technologies.
The GroundCLeaner proposal addresses to increase our competitiveness by developing a disruptive, rapid and costeffective method to remediate soils contaminated by chlorinated volatile organic compounds (CVOC), representing major threat to the quality of the European environment. The innovative method combines the state of the art ground water recirculation well (GWC) technology, patented by us, and a recently developed electro-biological treatment. Our aim is to further exploit the results of the novel technology proposed by providing a wider range of treatment. We aim at marketing this new combined technology for removal of CVOCs from soil, our services will include design, manufacturing, assembly, startup, maintenance and operation. The proposed technology targets to reduce the operational costs of remediation up to 70 %.
The success of our solution would strengthen our international position on the market and would make us grow by becoming market leader for chlorinated compound remediation. During this phase 1 proposal we would like to carry out a technological feasibility study, market assessment, risk assessment, a study on or freedom to operate, develop a detailed work plan for a Phase 2 application and elaborate a business plan. After successful phase 1 application we intend do phase 2 proposal, in which we develop the marketable GroundCleaner technology. The present proposal targets to make a pan-European impact as it will reduce the estimated 17.3 billion spent by EU countries, and 2.2 billion spent by EU Structural Funds for reversing the environmental consequences of soil and water pollution caused by industrial and other activities.";71429;50000;H2020-SMEINST-1-2014;SME-1;IEG - TECHNOLOGIE GMBH;DE;;; 196262;663530;OABCAP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Demonstration of a new diagnostic device for the Overactive Bladder syndrome;1/03/2015;31/08/2015;;"ALBYN MEDICAL has developed, in cooperation with the Chemnitz University of Technology and the University Hospital of Cologne (Germany), a specific diagnostic system for the Overactive Bladder syndrome. This diagnostic device is implanted by cystoscopy and measures the bladder pressure autonomously, relating the bladder pressure with the urination, controlled or not, and it determines if the pressure rise appears only when a voluntary urination occurs or if also occurs other times as in the accidental urine loss.
Thanks to the new diagnostic device a reliable diagnostic evaluation is obtained and thus high treatment costs of the current Overactive Bladder over-diagnosis are avoided improving the sustainability of the European Health and Care systems.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALBYN MEDICAL, S.L.;ES;;; 196293;663942;Springwave2014;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Transitioning to microalgae as a sustainable, high-quality large-scale food source through launching the first daily drink containing spirulina;1/02/2015;31/07/2015;;"To meet the challenges of growing world food consumption, environmental preservation and sustainable food production, spirulina has been identified as an extremely valuable solution by many international bodies. However, this microalgae is still a largely underutilised food resource. The reasons are organoleptic (foul taste and smell) and, most importantly, cultural (algae are not part of the Western culinary art).

To eliminate organoleptic barriers, ALGAMA brings a strong innovation by extracting high-quality nutrients from microalgae. To overcome cultural resistance, ALGAMA wants to create consumer awareness through an appealing mass-market product: Springwave, the first daily drink containing high-quality spirulina nutrients. This first product will be followed by a large variety of spirulina-based food products.

User needs to be met upon completion of the project are the trends (and societal challenges) health and well-being. Consumers are increasingly concerned with the nutritional properties of their food, but also that the food is natural and sustainable. Other user benefits are taste, texture similar to water and the ready-to-use approach.

The feasibility study will assess 3 key levels:
1. Commercial: Define strategy for mass-market expansion in France, UK, Germany, Netherlands and Sweden
2. Industrial: Analyse and decide on environment-friendly model to increase production capacity from 15 000 to 1 000 000 bottles per year
3. Legal: Identify legal and IP issues for the launch of Springwave outside France
For mass-market commercialisation of our spirulina-based beverage, total funding requirement during 2 years for Phase 2 is estimated at 3 300 000.

After testing its beverage in France, ALGAMA intends to expand in Northern Europe (UK, Germany, Netherlands and Sweden) where the health awareness is strongest and the functional product consumption highest, before entering into the first two biggest functional beverage consumption markets: USA and Japan.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALGAMA SAS;FR;;; 196119;661541;CMCG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Engaging Urban Youth: Community, Citizenship, and Democracy;1/03/2016;28/02/2018;;"Disadvantaged youth in urban environments often experience marginalization and disenfranchisement that can lead to disastrous consequences for them, their families, and wider society. We know that successfully engaging these young men and women in the institutions, communities, and contexts in which they live and building their capacity as social actors can be a critical factor in their positive development as individuals and future role as citizens. Yet, there is still relatively little known empirically about the specific contexts, strategies, and mechanisms through which disadvantaged urban youth can be most effectively engaged. This research is designed to develop the expertise of the experienced researcher to enable him to contribute much needed in-depth knowledge of how best to engage young people as citizens both civic and political actors with autonomy and responsibility for contributing to the common good. This work will be done through a comparative case study in three Irish cities. The methodology will involve a consultative process with designated stakeholders in each city including local politicians, policy leaders, service providers, service users, youth representatives and youth workers. It will involve field observations and interviews with young men and women in three selected case study cities, each having a distinct urban identity: Large multi-cultural (Dublin); Post-Conflict ( Belfast) and Smaller Regional City (Galway). Dissemination and Public Engagement are central to this proposal. The research will impact on the participating stakeholders by providing tangible and accessible research findings. It will impact on the field of urban youth studies by offering a comparative framework applicable to other urban contexts in Europe and globally. The impact for the experienced researcher will be the development of specific expertise with a view to developing further European and global studies of this important field.";187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;;; 196166;662421;FETAL MONITORING;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Safe and accurate fetal monitoring;1/01/2015;30/06/2015;;"Nemo Healthcare BV is a high-tech startup company established after years of research - that focuses on the development of innovative technology for fetal monitoring. Fetal monitoring is essential to safeguard the health of mother and child during gestation and birth. The goal is to timely detect problems, such as preterm birth, oxygen deficiency (fetal hypoxia) or growth restriction, so proper action can be taken to mitigate the effects of these problems on both mother and child.
Fetal monitoring consists of simultaneously monitoring uterine contractions and the fetal heart rate. Current methods are unsafe or not accurate (especially among overweight or obese patients (BMI>25; about 30% of the pregnant population).
There is a clear market need for fetal monitoring technology that is accurate, safe (non-invasive), easy to use and applicable independent of the BMI level of pregnant women. Since overweight and obese women face higher risks of complications and their number is steadily increasing, the need for improved monitoring technology is becoming more urgent every day.
Nemo is responding to this market need through the development of an innovative electrode patch and hardware/software module that can simultaneously record uterine activity and fetal heart rate independent of BMI levels. The solution of Nemo is characterized by unique and smart algorithms that can accurately and real-time filter contractions and the fetal heart rate from unprocessed abdominal electrophysiological signals, successfully eliminating noise or interference. The solution will be able to transfer the recorded data wirelessly.
The solution will create a breakthrough in the field of fetal monitoring: it will result in better diagnoses, improved quality of care, a reduced number of birth-related problems, increased user friendliness (for medical staff as well as the patient) and lower healtcare cost (through remote monitoring, reduced treatment and avoidance of unneccesary surgery).";71429;50000;H2020-SMEINST-1-2014;SME-1;NEMO HEALTHCARE BV;NL;;; 196091;661416;SiPhoN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Single-Photon Non-Locality;1/11/2015;31/10/2017;;"The principle of non-locality is one of the most impressive features of quantum mechanics. Usually, non-locality is related to two or more particles sharing a common characteristic. This quantum mechanical effect is well understood and several experimental demonstrations have been performed. However, non-locality of a single particle, in particular of a single-photon raises fundamental questions: Can a single-photon be simultaneously at different locations? In spite of numerous theoretical concepts, no clear experiment has yet been reported.
In this project, I will experimentally prove the non-local nature of a single-photon. To this end, I will create on-demand single-photons from nanowire quantum dots and measure the single-photon non-locality in a new homodyne detection scheme. This combines several future key technologies ranging from novel quantum light sources to superconducting materials, making the proposed research of broad interest in the European research community. In addition, this project will enable Single Quantum B.V. (the only European company developing superconducting detectors and in competition with Russian and US companies) to perfect their detection systems and optimize them for the emerging market of quantum optics applications that is expected to turn into a large market in this century.
A successful realization of the proposed research relies on four pillars: Resonance fluorescence (applicant: Dr. Joens), bright single-photon emitters (supervisor: Prof. Zwiller), efficient detectors (partner: Single Quantum B.V.), and the theoretical understanding of non-locality (host: KTH). Every single party contributes with its unique expertise to the big picture. This makes the proposed constellation of participating organisations essential for the success of the project. Together we will finally answer one of the fundamental questions in quantum mechanics: Single-photon non-locality.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KUNGLIGA TEKNISKA HOEGSKOLAN;SE;;; 196132;661629;PI-PEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pro-Internationalization Policy in the European Union The Challenge of Policy Efficiency and Coherence Post Lisbon;1/09/2015;31/08/2017;;"'The proposal introduces a novel technique, which has been developed by the fellow, Dr Miguel Torres (MT), in Portugal, to prototype pro-internationalization policy using a streamlined and innovative combination design of top-down and bottom-up approaches. The prototypes to improve policy design efficiency and coherence (PDEC) within each of the European countries, and in the European Union as a whole, will be realised through understanding the decision-making function relationships between companies and policy makers. The approach will employ questionnaires to policy makers, which have designed past incentives towards internationalization; and firms, which have used these same incentives. The insights gained will be used to generate models to explain the behaviour of both managers and policy makers in their actions and to arrive at set of principles of action for PEC. The work plan will be executed at the University of Leeds at a time when there is an EU policy (Lisbon Treaty) highlights the need of coordination of policies, the coherence in external relations, and the consistency with the potential complementarities between trade and FDI within EU members and considering third countries.'";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LEEDS;UK;;; 196214;662932;BioStomy;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Development of manufacturing process for a novel multi-layer film comprising of a water-soluble polymer and a bio-compostable polymer to enable flushable ostomy pouches;1/05/2015;31/10/2015;;"Ostomy drainage pouches are medical devices made of heavy-duty plastic used to collect waste from a surgically diverted colon, ileum or urinary system. Unfortunately, their disposal can cause users psychological, social, and work-related problems, negatively affecting their quality of life. Soiled ostomy devices become domestic waste and the heavy-duty plastic is non-bio-compostable and so ends up at landfill sites with over 850 million ostomy pouches disposed in landfills annually across the EU representing more than 100,000 tonnes of liquid and plastic waste.

BioStomy seeks to address challenges faced by ostomy pouch users, by providing an industry first, fully flushable ostomy pouch, enabled through the combined use of advanced water soluble and biodegradable material and a novel advanced manufacturing process involving a single co-extrusion of these materials and an adhesive layer.

We anticipate that over a period of five years, we will be able to replace 5.49 million pouches making a profit of 23.79 million and saving over 600 tonnes of plastic waste from landfills. Eucomed estimates that about 0.14% of the total population (700,000 citizens) in the EU has an ostomy and so BioStomy addresses Europes challenges of an increasingly ageing society and reducing waste by providing an innovative, ostomy pouching system that is environmentally friendly and convenient for users.

In the Phase 1, we intend to investigate the dynamics of the co-extrusion process, study the market and investigate potential alternative applications for our product.

The aim of Phase 2 will be to reduce the thickness of our novel multi-layer material so as to reduce cost and increase usability and manufacturability. Secondly, to prototype and validate a high volume advanced manufacturing process using a single multi-layer differentiated co-extrusion to produce the prescribed film.";71429;50000;H2020-SMEINST-1-2014;SME-1;ACEDAG SCIENTIFIC LIMITED;UK;;; 196260;663509;BIOCURE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Novel Biomaterial for Improved and Cost-efficient Wound Healing;1/03/2015;31/08/2015;;"Wound treatment is a major healthcare cost for all developed countries. The global market for advanced wound care products was projected to be $ 3 billion in 2012, with an annual growth above 10% and representing one of the leading medical product sectors . However, this represents only some 15-20% of the overall cost of wound treatment, where hospitalisation and nurse time represent the remaining costs.
BIOVOTEC aims to pursue a major market opportunity by developing a novel biomaterial based cost-effective wound dressings that can be used for initial treatment of all wounds at risk of delayed or non-healing, reducing the incidence of chronic wounds. BIOCURE range products will be safer, potentially more effective, much more easily scalable and significantly lower in cost when compared with the available advanced wound healing products.
BIOCURE is an opportunity for BIOVOTEC to enter the world-wide advanced wound care market and maintain the European competitive position in the growing biotech and wound management sector. The accomplishment of the project objectives will thus represent a significant business opportunity for BIOVOTEC. Furthermore, BIOCURE will positively impact clinicians and patients through early stage treatment or resolution of chronic wounds.
In the feasibility study, we plan to develop and test business models for two key European markets (Scandinavia and UK). The results from this study will allow us to develop viable business models, supply chains and product requirements, thereby minimizing the financial risks of following investments in development of an approved/qualified products and clinical validation in a phase 2 SMEINST project. The phase 2 project will develop industrial process, validate and demonstrate the benefits of BIOCURE product range before large-scale commercialization.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOVOTEC AS;NO;;; 196122;661561;IMAGINACTIVISM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;"Cultural production, social movements and virtuous spirals; Using cultural production to influence social transformation. An ethnographic case study of a transmedia and translocal experiment.";1/12/2015;30/11/2018;;"In this action I will track the people and processes involved in adapting the novel The Fifth Sacred Thing as a transmedia phenomenon, whose stated goal is: to help nurture and support the movements that are already growing to put our world on a path of peace, justice and ecological harmony. I will focus on the producers intentions to be faithful to the books artistic vision but also to the values of earth-care and social justice the book represents. I will explore the ways that they work to set new standards for environmental accountability in the film industry bring resources into the inner city by networking with community organizations put up a website with extensive resources and develop many ways that the people who are inspired by the vision can learn the skills they need to create it and connect with others who share it. Together, the books artistic vision and the producers plans provide a rich case study in inventive approaches to creating, inclusive, innovative and secure societies. I will use this empirical case study to develop and test the concept of imaginactivism as a way of thinking through the influences fictional or artistic cultural productions exert on social and political activism, and vice versa. I will pursue research skills training in new media research and production, as well as videoethnography, so that my research methods, dissemination, and public engagement mirror and extend the phenomenon I am investigating. This will enable me to meet the objectives of: producing articles and a monograph about the transmedia phenomenon of The Fifth Sacred Thing; articulating the methods to ground conceptual work on imaginactivism through an empirical case study; disseminating the methods to academic audiences pursuing research on cultural production and social activism; disseminating a road map for linking cultural production and social and political action to cultural producers, activists and potential activist publics.";251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;CARDIFF UNIVERSITY;UK;;; 196093;661398;ARC-HPV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Automated Raman spectral Cytology for detection of human papillomavirus (HPV) infection and cervical pre-cancer;18/01/2016;17/01/2018;;The Experienced Researcher (ER), Dr Shiyamala Duraipandian, who is at the centre of this application, will, through this MSCA Fellowship, enhance her research and innovation potential through advanced training, international and inter-sectoral mobility. The ER will develop methods for detecting high risk HPV infection and dysplasia using Raman spectroscopy in cervical cells collected during routine Pap smear screening. Her skills in instrument and software development and patient testing will complement the expertise of the host laboratory. During the project measurable knowledge transfer towards the ER will be facilitated through DITs Postdoctoral Training Programme, RESC induction and specialist skills transfer, strengthened academic and industry network contacts, via existing networks and industry events, and preparation of a dedicated career development plan.;175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITIUID TEICNEOLAIOCHTA BHAILE ATHA CLIATH;IE;;; 196204;662802;BIO-OXIDATED S2;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;BIO-OXIDATED S2: THE SOLUTION TO USE ORGANIC SLUDGE, NON-HAZARDOUSINDUSTRIAL WASTE AND URBAN GREEN WASTE TO MAKE BRICKS.;1/03/2015;31/08/2015;;"The project aims to employ organic, urban and industrial sludge, along with non-hazardous waste from industrial processes and along with urban green waste, in the production of bricks with enhanced heat insulating capacity. This is made possible by an innovative compound called Bio-Oxidated S2, patented by the consortium.
The purpose of the project is to create a pilot plant for producing Bio-Oxidated S2 and also to develop a new business model that will set up a production chain consisting of waste disposal companies and brick manufacturers in order to duplicate this chain in major brick producing areas in Europe.
An industrial-sized plant for producing Bio-Oxidated S2 will be able to dispose of 50,000 tons of organic sludge, 30,000 tons of urban green waste and 20,000 tons of non-hazardous waste material from industrial processes per year. It will produce 50,000 tons of Bio-Oxidated S2 and provide 15 new jobs. Used as an additive to clay, this amount of Bio-Oxidated S2 can be employed to produce 300,000 tons of brick per year, and these bricks will have a thermal conductivity index that is 15% lower than the finest bricks currently available (which will lead to better heat insulation in new buildings), while saving 50,000 tons of raw materials (30,000 tons of clay and 20,000 tons of sand) and 1,500,000 m3 of natural gas used for baking the bricks.
The project helps mitigate or solve important industrial and social problems, because it: 1) increases the percentage of organic sludge that is recycled; 2) reduces the amount of raw materials used to produce the bricks; 3) lowers the consumption of natural gas in the brick production process; 4) helps increase environmental compatibility in the building construction sector.
The project develops an industrial symbiosis whereby different actors derive mutual benefit from sharing utilities and waste materials and it will be possible to turn waste from one industry into useful feedstock for another one.";71429;50000;H2020-SMEINST-1-2014;SME-1;TIRSI SrL;IT;"ECOFOR SRL;ARGITEK SRL";IT; 196115;661526;IMAGUS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Styles of Objectivity: Agency, Alignment, and Automation in Image-Guided Surgery;1/09/2015;31/08/2017;;Advanced imaging technologies are currently transforming operating rooms into sophisticated augmented reality studios that explore recent developments in computer visualization, navigation applications, and robotic systems. The new imaging methods promise to increase precision and improve health outcomes. However, as medical diagnosis and therapy grow more dependent on images, the status and roles of these images become increasingly controversial. Image-guided applications reshape clinical practices, impact medical decisions, and transform the relationship between physician and patient. The objective of the project is to develop a new framework that accounts for the active role of images in surgical contexts, providing a systematic basis for handling the impact of these images and assessing their controversial aspects. The project pursues its goal through a collaborative and interdisciplinary effort that involves medical practitioners. It articulates the visual knowledge of medical practitioners by undertaking in-depth operational analyses of three image-guided technologies in current use: the 3D Slicer software application, the da Vinci surgical system, and the CyberKnife robotic radiosurgery system. The analyses introduce the notion of styles of objectivity, which accounts for the key features of these applications, including agency, alignment, and automation, while acknowledging that images have a certain agency and that there is an inner connection between aesthetic and epistemic factors. A second objective of the project is to contribute to conceptual and methodological innovation through a two-way transfer of visual literacies across medicine and humanities/social science domains, by operationalising the visual knowledge of surgical practitioners so that it can be fed into visual/media/science studies, and vice versa. This includes developing concepts for new ways of teaching the visual knowledge of medicine.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HUMBOLDT-UNIVERSITAT ZU BERLIN;DE;;; 196156;661864;EKOMAP;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Eco friendly marine antifouling paint;1/02/2015;30/06/2015;;The objective of the proposed project as a whole (phase 1-3) is to plan, develop, secure and bring to market an innovative non-toxic and eco-friendly self-polishing boat hull paint. In the proposed project Ekomarine Paint AB will introduce the patented non-toxic anti-fouling marine hull paint to the European and the global commercial shipping market and to the global leisure boat industry. The reason why Ekomarine Paint can do this, and no one else, is that the innovation is based on a patented technology and over 11 years of research (before year 2007 research had been performed in Ekomarine AB since 2003). Exactly what we wish to achieve through the project is to develop an optimized application for commercial vessels (which is a new market for the company) and a much improved application for leisure boats (partly existing customers). This will be achieved through a well-planned project plan where Ekomarine Paint will demonstrate in full scale and in real environment, in conjunction with potential customers, the functionality, economic and environmental benefits as well as working environment improvements in various geographical and meteorological settings. In terms of technology readiness level (TRL) we will move from TRL 6 towards TRL 9 during the project life-cycle.;71429;50000;H2020-SMEINST-1-2014;SME-1;EKOMARINE PAINT AB;SE;;; 196131;661622;InCisive;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;creTRAP for in situ Characterization of Fibrosis-Promoting Pathways in Non-alcoholic Fatty Liver Disease;1/03/2016;28/02/2018;;The aim of the proposed project is to develop and employ novel tools to identify and target fibrosis-promoting, molecular pathways in non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Affecting 20-30% of the Western population, NAFLD is now the most common liver disease. Yet, the lack of tools for studying the initiation and progression of NAFLD at the cellular level limits our ability to develop novel strategies for rational, therapeutic intervention. This proposal details a cross-disciplinary research project aimed at addressing this challenge while facilitating the transfer of knowledge and new technologies to the Danish biomedical research community. Over the course of the proposed project, the aim will be pursued through fulfilment of these specific objectives: (A) Development of novel biochemical tools for in situ gene expression profiling and gene knock-down in select cell types. (B) Implementation of these tools to discover intra- and intercellular mechanisms linking metabolic stress to chronic liver disease in mouse models of diet-induced fibrosis. (C) Cross-disciplinary, experimental validation of hypotheses generated from bioinformatic integration of gene expression profiles from individual cell populations and experimental treatment of NAFLD in animal models. (D) Communication of discoveries and their relevance through external seminars and through scientific, popular, and social media platforms. Through research and training activities at the University of Southern Denmark, development of collaborations with researchers at partnering institutions, and dissemination of results to the broader European community, the proposed project serves as foundation for my independent career in European biomedical research. Concurrently, the proposed project has the potential to greatly improve our understanding of chronic liver disease and devise novel treatment strategies.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SYDDANSK UNIVERSITET;DK;;; 196268;663613;IcoCell;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;IcoCell? Chassis for Enhanced Mammalian Cell Line Development and Engineering;1/04/2015;30/09/2015;;The opportunity to focus on the production of biopharmaceuticals is often taken from SMEs since huge amount of resources is required for the development of high-producer cell lines. We envision that our parental cell factories will increase the efficiency of cell line engineering and will effectively reduce the time-to-market for mammalian cell-based products. It allows SMEs to leverage their traditional strengths of adaptability and creativity, and to develop novel products for biotechnology industries.;71429;50000;H2020-SMEINST-1-2014;SME-1;ICOSAGEN CELL FACTORY OU;EE;;; 196247;663327;Ripesense;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;An innovative fruit ripeness checker, to offer non-destructive testing in order to ensure resource efficient fruit processing - Ripesense;1/04/2015;30/09/2015;;"Fresh fruits for the consumer market can only be sold as such if they are shown to be a certain standard of ripeness, as judged by the sugar content and firmness. There is great commercial pressure on producers to provide produce which is of the appropriate standard. Apples which do not meet this standard can be sold to the wholesale market or juiced with losses to market value of 50% and 95% respectively, but apples & citrus fruits which are destructively tested are sold as animal feed, composted or sent to landfill.
As a result, fruits are tested many times during the production cycle, both in harvesting and distribution. Unfortunately, the most widely used tests for both are destructive tests. This leads to the destruction of between 6 8% of harvested apples and approximately 5% of citrus fruits for testing purposes. Worldwide, this would amount to 4.6 6.1 million tonnes of apples and 6.6 million tonnes of citrus fruit annually. At average European prices, this represents a combined economic loss of 6.3 7.2 billion every year.
Ripesense is an innovative solution to this problem. The objective of our project is to develop and produce an automated system capable of non-destructively testing both the firmness and sugar content of fruits, initially apples and citrus fruits.
The main benefits of these performance objectives are to provide a system that can:
Replace destructive test methods with non-destructive Ripesense, reducing waste fruit going to landfill by 50%
Reduce greenhouse gas emissions produced by waste fruit sent to landfill
Reduce customer complaints 30% by using Ripesense frequently to minimise risk of overripe fruit reaching consumer
Reduce time & labour testing fruits for ripeness, enabling a 50% reduction in QC staff for more advantageous deployment
Allow fruits to be optimally distributed to retailers with different quality criteria, further increasing yield efficiency by ~10% apples";71429;50000;H2020-SMEINST-1-2014;SME-1;NORTH COURT FRUIT FARM;UK;;; 196278;663742;WHEY2VALUE;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Whey2Value: valorising waste whey into high-value products;1/02/2015;31/05/2015;;ACIES BIO has developed an innovative and disruptive high-value technology to address a major economical and environmental challenge of the worlds dairy industry: waste whey. Over 200 million tons of whey is generated annually, and only limited economical solutions exist to process it. The innovative patent pending technology Whey2Value uses a unique bioprocess to utilize whey as a primary ingredient for microbial fermentation to produce sustainable high-value products, such as vitamin B12. The technology greatly reduces the negative impact on the environment by almost eliminating the organic content of the wastewater, allowing for its recycling, while the product of the technology is a protein-rich biomass with high content of vitamin B12 to be used as a very high quality animal feed to complete the dairy industrys circle. The innovation W2V is perfect example of how circular economy should work. The Whey2Value technology requires a very low-cost processing facility, which can be installed on site, and minimal maintenance costs. It represents a truly unique opportunity to create a huge and disruptive impact on dairy industry, particularly for the competitiveness of small and medium sized European dairy companies, generating high-value products from waste material, and at the same time creating a sustainable solution with a greatly reduced burden to the environment. The objective of this project proposal is to prepare a thorough business plan and feasibility study in the scope of Phase 1, followed by scaling-up and demonstration of operational technology in industrial setting with a local dairy company in the scope of Phase 2. The technology is ready for industrial demonstration, which will be followed by EU and global commercialization of Whey2Value. We expect a rapid worldwide market adoption of this disruptive eco-biotechnology.;71429;50000;H2020-SMEINST-1-2014;SME-1;ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO;SI;;; 196104;661480;PlasmaPerovSol;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A full plasma and vacuum integrated process for the synthesis of high efficiency planar and 1D conformal perovskite solar cells;1/01/2016;31/12/2017;;"Photovoltaic or solar cells (SC) devices that transform light into electricity- have been extensively studied in the last decades since they represent a promising way to exploit the sun energy. Currently, perovskite-based solar cells(SC) are receiving increasing attention due to their low cost and high efficiency. They are very promising as an alternative for the existing ones, but still need to advance to reach higher efficiency and durability and require synthesis methods compatible with the industrial production of CMOS devices at wafer scale. These recent SC are mostly fabricated via wet methods in planar architecture. Inherent to the nature of the wet approaches, usually appear several drawbacks as contaminations and chemical reactions on the interfaces that might result deterioration of the SC performance.
PlasmaPerovSol main objective is the fabrication of a complete perovskite solar cell device by a full plasma and vacuum integrated process carried out under the premises of the one reactor concept. Thus, the different components of the solar cell will be deposited sequentially within a vacuum reactor avoiding exposition of the materials and interfaces to air or solvents. The technology developed by the hosting group combine vacuum deposition assisted by plasma that permits the fabrication of conformal layers over a large variety of templates. This approach is also proposed here to fabricate conformal multilayers over 1D scaffold that will demonstrate the advantages of 1D-SC. Plasma and vacuum processes present as advantage the high purity and stoichiometric control on the deposition within an ample range of materials compositions. The synthesis approach is compatible with large scale industrial production and allows the fabrication of SC on processable and flexible substrates. At the same time, the low temperatures used make the approach compatible with current CMOS technology and by using masks permits their integration on preformed devices.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 196078;661317;POLYCOMP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;POLYmer-COntrolled Mesocrystal application-oriented Production: a combined theoretical and experimental approach.;1/09/2015;31/08/2017;;POLYmer-COntrolled Mesocrystal Production (POLYCOMP) aims to develop an intimate understanding of the underlying mechanisms of mesocrystal formation. This in turn will lead to the development of new mesocrystals with controlled morphologies and thus optimised properties. Mesocrystals have only very recently been described and are best viewed as an entirely new class of material. As such these unique substances have the potential to revolutionise materials/devices containing inorganic components. Applications are myriad and include building materials, such as concrete, with vastly greater compression strengths (in theory at least, the heights of concrete buildings could be increased from 500m to 15km!), solar cells with far higher solar harvesting efficiencies, new biomimetic materials, e.g. for use in joint replacement procedures, and electronic devices where size-dependent nanoparticle-like properties, e.g. superparamagnetism, are retained in macroscopic-sized materials enabling easier manufacture of components such as computer memory, quantum dot-based LEDs, etc. Currently approaches to mesocrystal formation are somewhat ad hoc and these kinds of application remain largely unachievable. The principle underlying reason for this is that mesocrystal formation processes are often still too poorly understood. POLYCOMP will remove this bottleneck to mesocrystal exploitation by focusing directly on developing a generic understanding of mesocrystal formation processes. Such an approach is thus clearly directly relevant to the EUs mission to advance knowledge and technology in areas such as construction, electronics and energy.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 196151;661799;COMPLEX-fastMAS-NMR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structure of a large non-crystalline multiprotein assembly by solid-state nuclear magnetic resonance with ultra-fast magic-angle spinning;1/01/2016;31/12/2017;;"Extrapolating from protein structure to function is an operation difficult to accomplish, as most functions in the cell are not carried out by single proteins, but by macromolecular complexes containing multiple subunits endowed with specific functions. Despite the many advances in structural and biochemical studies of isolated molecules, a comprehensive portrait of cell biochemistry must thus include insights of the supramolecular network of interactions among the individual constituents. The structure determination of large and dynamical protein ensembles presents a great deal of challenges for X-ray diffraction techniques, and for solution nuclear magnetic resonance (NMR) due to the large size of these objects. Consequently, there is little information available today on the overall organization of the assembly subunits, their interactions, and sometimes their precise function within the cell. High-resolution solid-state NMR (ssNMR) has recently developed as a powerful structural tool for studying structure and dynamics of solid biological samples at atomic resolution. A number of issues remain however to be addressed before ssNMR is ready to cope with large-sized multi-domain functional assemblies.
The proposed project aims to capitalize on new concepts recently introduced by the host institution, to implement innovative solid-state NMR methodologies. Sophisticated experimental approaches will be introduced at high magnetic field, in combination with ultra-fast magic angle spinning (MAS), enabling the structure characterization of non-crystalline assemblies that cannot be currently carried out by any other experimental technique, and notably, the determination at atomic level of the structural details that govern protein-protein interactions in functional assemblies. As a benchmark, we will tackle the interaction mode of the ring-shaped hexameric DnaB helicase with its partner DnaC, an assembly that controls the origin of the DNA replication in E. coli.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196117;661528;EMBRACED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Brain and Culture in Europe: Development of an European Domain Specific Computerized Battery for Cross-Cultural Neurocognitive Assessment;1/06/2015;31/05/2018;;European Union (EU) is constituted by citizens from diverse cultures and countries. This is important in many aspects but it has also a great impact on neurocognitive functioning assessment. Recently new variables related with the modulating effect of culture on the cognitive system have been proposed to explain differences in neurocognitive performance among people from different cultures, ethnicities or minorities. The influence of culture on neurocognitive tests is so important that DSM-5 states that neurocognitive instruments used to diagnose neurocognitive disorder must have culturally adapted norms. To date, there is no neurocognitive battery accounting for cultural differences to be used in different countries in Europe. The objective of this project will be to develop a comprehensive and domain-specific computerized neurocognitive battery for its use in adult European citizens: EMBRACED battery. Standardized norms will be obtained in eight European countries assessing a total of 1.920 participants. Results on these participants will also allow robust conclusions on cultural variables affecting neurocognitive performance.;257191,2;257191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSIDAD DE GRANADA;ES;;; 196199;662750;PROMETHEUS-5;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Energy efficient and environmentally friendly multi-fuel power system with CHP capability, for stand-alone applications.;1/02/2015;31/07/2015;;The primary objective of the Prometheus-5 project is the field testing, standardization and industrialization of a highly innovative, energy efficient and environmentally friendly power production system, mainly for decentralized power generation. The device is able to convert the fuel (LPG/Natural Gas/Biogas) into electrical and thermal power, with intermediate production of hydrogen, by means of a Proton Exchange Membrane (PEM) fuel cell. Hydrogen is produced on site, via the reformation of the fuel, and feeds the PEM fuel cell, resulting in the production of electrical power. The nominal capacity of the power system is 5 kWe, while, in the case of CHP, an additional 7kW of thermal energy is produced. Regarding its electrical efficiency, it is greater than 35%, while the total efficiency, when thermal power is included, exceeds 85%. The proposed innovative and efficient technologies address major EU and global challenges, dealing with both environmental and efficiency issues and they are in accordance with the Roadmap for moving toward a low-carbon economy in 2050. The product targets decentralized power production, where numerous applications have been identified. The sectors that will mainly be focused on are the followings: telecommunications, biogas production plants, transportation, marine, households, hospitals, etc. Currently, this market segment is served by diesel or gasoline generators which rely on mature and relatively low cost technology. However, the proposed system has electrical efficiency twice that of the conventional technology and less than half of its emissions. Also, it presents lower operational and maintenance costs and noise-free and reliable operation. The main objective of phase 1 of the project is to conduct a feasibility study evaluating all aspects of the commercial application of the developed product. This will include conduction of market and techno-economic studies, SWOT analysis, exploration of market and product strategies, etc.;71429;50000;H2020-SMEINST-1-2014;SME-1;ELVIO ANONYMI ETAIREIA SYSTIMATON PARAGOGIS YDROGONOU KAI ENERGEIAS;EL;;; 196245;663292;BLUE IODINE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Boost BLUE economy trough market uptake an innovative seaweed bioextract for IODINE fortification;1/02/2015;31/07/2015;;"The main objective of the project is to produce in a cost effective way new high quality seaweed iodine products and become market leaders in this niche market. The expected revenue in 5 years will be 3,3 million euro and we expect to increase our staff in 20 people.
Iodine deficiency is one of the three most common nutritional deficiencies and is spread all over the world and 40% of the worlds population remains at risk for iodine deficiency.
Seaweed is the most reliable source of natural iodine. However, seaweed creation is dominated by larger players, mainly from Asia. Our strategy is not to compete with them, but target for a niche market that is yet incipient - high quality seaweed creation for the development of natural protein products, rich in essential aminoacids and natural iodine.

The seaweeds created in the fish aquaculture farms are autochthonous from our region and have a high iodine content and a high degree of stability. They are better than the products in the market (iodine composition 30% higher and vitamin C 300% higher than usually commercialized seaweed products) and with our already tested innovative biorefinary process we will be able to put the product in the market at a competitive price (10% to 30% lower).A nutritional analysis has been done. The biorefinary process has been developed for small production. This has now to be better defined in order to process a higher amount of products.

UBQ is a high-tech company, and are specialized in the production of natural extracts obtained from marine seaweed.
For the 1st stage project, the objectives are to study the:
1.1. Refinement of the nutritional and biochemistry analysis of the selected seaweed
1.2. Requirements for upscale the innovative biorefinary process for a higher production
2.1. Refinement of the Market analysis at EU and global level
2.2. Business Plan, including defining in detail the prices, commercialization strategy, possible partnership.";71429;50000;H2020-SMEINST-1-2014;SME-1;UBQ II LDA;PT;;; 196107;661491;DrugsUP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Solute carrier proteins and the uptake of cytotoxic approved drugs;1/05/2015;30/04/2017;;The transport of nutrients and metabolites across lipid membranes is a critical and essential biological process in both normal and pathological conditions. Specialized integral membrane proteins known as transporters are responsible for the movement of virtually any known class of biologically active molecules across membranes. Perhaps not surprisingly, there is increasing evidence that many drugs in clinical use also employ carried-mediated transport as the predominant entry method into the cell. Understanding the molecular and physiological basis of transporter-mediated drug uptake is therefore a key step toward the development of improved pharmacokinetics and models of toxicity for current and future therapeutically active compounds. We hypothesize that most approved drugs may require specific members of the solute carrier (SLC) family to cross the cell membrane, a phenomenon that would directly affect the compound activity, and that this process is basically underestimated in its importance. To test this hypothesis, the study proposed here aims at identifying SLC transporters involved in the uptake of a well-characterized set of commercialized drugs. The CeMM Library Of Unique Drugs (CLOUD) is a library of 300 compounds selected to be representative of the chemical space covered by all commercially available drugs. Human cell lines carrying deletions on specific SLC proteins will be tested for their ability to resist toxicity or challenges due to CLOUD compounds, allowing us to determine which transporter or family of transporters are involved in the uptake of specific drugs classes. The information derived from these studies will represent an important step forward toward a systematic characterization of the role of carrier-mediated transport in drug uptake.;178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH;AT;;; 196075;661271;REBuILD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploring the role of TFEB in exosome biology and in novel approaches for treatment of lysosomal diseases;1/01/2016;31/12/2017;;Exosomes are small vesicles released to the extracellular environment by almost every cell type, with important functions in mediating intercellular communication in several physiological processes, including organism development, immune responses, neuronal communication and tissue repair. In addition, these vesicles have attracted much interest from the biomedical research community for their potential as biomarkers for diseases, therapeutic agents and vehicles for drug delivery. Despite this, little is known about the mechanism and molecular players involved in exosome biogenesis and secretion. The aim of this application is to expand our current knowledge on exosome biology and their therapeutic potential. Preliminary results suggest that Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis, lysosomal exocytosis and autophagy induction, also controls the expression of various exosome-associated genes. By using mouse and human cells upregulated or knocked-down for TFEB expression, the applicant will establish a role for TFEB in exosome biogenesis, cargo selectivity and secretion. Furthermore, the applicant will determine the role of other TFEB-related cellular pathways, including starvation and Ca2\-related pathways, in regulating exosome formation. Finally, the applicant will explore the therapeutic potential of exosomes in cellular and mouse models of lysosomal storage disorders (LSDs). Collectively, this application combines both basic research and translational approaches to expand our current understanding of exosome biology and to provide proof of principle for novel therapeutic approaches of rare diseases.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDAZIONE TELETHON;IT;;; 196141;661715;BASILA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification and characterization of bacterial effectors that interfere with Transcriptional GeneSilencing in Arabidopsis;16/11/2015;15/11/2017;;Transcriptional gene silencing (TGS) is an ancestral gene regulatory mechanism that operates at the level of chromatin and that involves various histone modifications as well as cytosine DNA methylation. In both plants and animals, DNA methylation transcriptionally silences transposable elements (TEs), repeats, as well as some protein-coding genes that carry TEs/repeats in their vicinity. Whereas DNA methylation has been extensively studied at particular stages of plants and animals development, its dynamics and biological relevance in response to biotic stresses, and particularly during bacterial infections, has just started to be examined and reported. Previous work from the host laboratory has revealed that disease-related genes are negatively regulated by DNA methylation and that DNA demethylation is required to enable proper plant innate immune response. Together, these results suggest that some yet-unknown bacterial virulence factors must have evolved to interfere with TGS to enable disease. The proposed project aims at identifying and characterizing such bacterial effectors as well as their interactants, namely epigenetic factors. To address these questions, the bacterial pathogen Pseudomonas syringae and the plant Arabidopsis thaliana will be used as model systems and biochemical, genetic, epigenomic and cell biology approaches combined. The proposed project sets the grounds for further mechanistic analyses of the effector-target complexes that will shed light on the precise mode of action of these epigenetic effectors and their targets. This study will not only unveil novel mechanisms of bacterial pathogenicity but also allow the identification of novel silencing factors and therefore enhance our fundamental knowledge of TGS mechanisms in plants and possibly other eukaryotic organisms.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196100;661451;CHAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Control of the Homeostasis of Actin through Time: actin homeostasis during embryonic development by means of single-molecule imaging and simulation in C. elegans;1/04/2015;31/03/2017;;"In embryonic cells, actomyosin forms a cortical reticulated gel that turns over rapidly, is weakly organized, and is composed of a variety of structures, with distinct architectures and dynamics, which are nucleated and elongated by different factors, and bind to specific sets of actin-binding proteins that modulate their dynamics. Understanding how actin is distributed between these structures is critical to understand the biology and mechanics of the actin cytoskeleton and therefore its role in processes ranging from morphogenesis and cell division to endocytosis and polarization.
In the proposed work, taking advantage of single-molecule techniques I developed during my previous post-doc, I will use the early C. elegans embryo as a model system to tease out the general rules and the critical regulatory elements that control actin homeostasis. I will follow three major directions: (1) analysis of actin dynamics in a steady-state system, the 1-cell stage embryo during maintenance phase, (2) analysis of the mechanisms underlying actin homeostasis in face of changes in the concentration landscape and biochemical properties of the players and (3) analysis of the modulation of actin dynamics and homeostasis during early embryonic development and between different cell types.
I propose here a research program to expand our knowledge of how the structure of the actin meshwork is regulated and controls morphogenesis in embryonic cells, and in particular the mechanical properties of the cell. Importantly this program explores how modulations of the concentrations of actin-interacting proteins impinge on the dynamics of the actin cytoskeleton as a whole, and should improve our understanding of the general mechanisms that underlie the regulation of the actin cytoskeleton machinery, and how deregulations may be responsible for the onset of specific behaviors of the actin cytoskeleton that may eventually result in the development of cancer-like cellular behaviors.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196116;661527;NMJALS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;In vivo analysis of neuromuscular junction stability in zebrafish models of amyotrophic lateral sclerosis;16/11/2015;15/11/2017;;"Amyotrophic lateral sclerosis (ALS) is a late onset, lethal neurodegenerative disease of motor neurons that affects about 2 in 100,000 individuals per year. Different genetic mutations have been described in patients, but the genes involved seem unrelated and the causes of the disease appear complex and are still largely not understood. Of relevance, the destabilisation of neuromuscular junctions (NMJ) may be an early event, preceding neuronal death, making them an interesting therapeutic target to slow down disease progression. The goal of the study is to characterise the molecular organisation and dynamics of NMJ, in particular of cell adhesion molecules, in order to understand the mechanisms of maintenance of NMJ by analysing defects in their organisation in ALS contexts. Technically, we plan to combine neuron biology, quantitative cell biology and computational tools to reach a precise molecular understanding of the dynamic equilibrium of NMJ in zebrafish, an excellent vertebrate model for live imaging. We will develop innovative methods of super-resolution microscopy and of quantification of protein turnover using a fluorescent molecular clock. This precise molecular characterisation of the NMJ will allow detecting subtle early changes in the NMJ that occur before neuronal degeneration starts, in fish carrying mutations described in ALS patients. The project will lead to the identification of key proteins for NMJ stabilisation and enable the analysis of regulatory elements of this stability, especially the cytoskeleton.
The innovative multidisciplinary approach of this study will unravel early modifications in the organisation of the NMJ preceding neuronal degeneration in ALS contexts. It will point out key proteins of NMJ maintenance constituting new targets for the development of therapies to counteract destabilisation of neuromuscular junctions, regardless of the genetic specificity of the patient.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT CURIE;FR;;; 196189;662652;BigDataScore;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Improving loan quality and acceptance rates by predicting credit behavior through social mediadata.;1/03/2015;30/06/2015;;"The problem: Credit Losses on Banks Loan Portfolios - Youngsters and 2nd generation immigrants still have difficulty in obtaining credit.

The solution: Our credit scoring model called Big Data Score assesses the credit quality of people and accurately predicts their payment behaviour based on data from social media (Facebook) and internet browsing behaviour.

Objectives of the overall innovation project:
1) Bring the present Technology Readiness from level 7 to 9.
2) Provide the system with complete access to real life data and Open Data made available from governments.
3) Development of a marketing and sales strategy based on two key principle: vertical approach and distribution approach.

Value Proposition: To help lenders to save money on credit losses and to make more money on increased acceptance rate.

Business Model: Business follows a simple and easily scalable model where lender pays for each score:
0.99 EUR per Facebook score and 0.20 EUR per browser score.

Users/Clients: Our target client is anyone who is taking a short to medium term (1-36 months) credit risk.

Competition: Traditional credit bureaus and innovative credit score (Kreditech, Leendo, ZestFinance).

Revenue Streams: 36M revenues at the 3rd year after commercialization.

Team: Big Data Scoring AS, Aasa Global AS.

Required funding: 1,5M";71429;50000;H2020-SMEINST-1-2014;SME-1;BIG DATA SCORING;EE;AASA GLOBAL AS;EE; 196232;663118;Bioprene;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Bio-based high-purity isoprene through high-yield technology;1/04/2015;31/07/2015;;"Visolis represent the future in cheap sustainable isoprene. About 770,000 metric tonnes of Isoprene are produced annually and commonly used in tyres, but also many other rubber applications including medical equipment, toys, shoe soles, textiles.
Currently the cheapest way to produce Isoprene is via its extraction from the steam by-product of ethylene production from crude oil cracking. However due to rising crude oil prices, ethylene is being produced more and more via natural gas that does not create isoprene as a by-product, risking a shortage of isoprene and a subsequent rise in its price. In addition, crude oil cracking releases a lot of C0? into the environment, about 5.4 tonnes of CO? during the entire lifecycle procedure, contributing the greenhouse effect.
Visolis have developed a new microbe and supporting process technology to produce bio-based high-purity isoprene, bioprene. The solution uses proprietary technology based on a bioengineered microbe that converts renewable materials (plant sugars) into isoprene with a high yield. Therefore Visolis are able to produce isoprene for less than half its current market price through a process that emits 4 times less the amount of CO?. Visolis method can be industrially implemented by retrofitting bioethanol manufacturers existing fermentor systems.
Visolis bioprocess is at Technology Readiness Level 6 moving towards TRL 9. Phase 1 project aims at assessing the activities needed to standardize the product, scale up to a large pilot implementation and test the market to achieve a sound business model.";71429;50000;H2020-SMEINST-1-2014;SME-1;VISOLIS TECHNOLOGIES LTD;UK;BIOSPHERE SRL;IT; 196253;663463;iLocator;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;iLocator - Map, track and manage point-based-assets;1/01/2015;31/05/2015;;"The problem: OECD countries, on average, spend more than 2% of GDP on maintenance of road, rail, sewage, water, park, power, telecom, and harbour and airfield infrastructure. Specifically, sewage maintenance is an increasing cost for municipalities with the growing number of flash floods in Europe, which in turn puts enormous pressure on gullies to diverge water. It is expected that the occurrence of these events will continue to increase in the near future. Therefore, servicing and maintenance of this infrastructure will become even more important to prevent flooding.

The market: Local authorities/municipalities are typically responsible for the service and maintenance of physical infrastructure such as roads, traffic signs, storm drains (gullies) and trees (i.e. assets). Municipalities across Europe spend a large part of the renovation budget on gully cleaning, given the number and high frequency of the maintenance service. Due to the sheer number of gullies within a single municipality, logistics are becoming increasingly difficult and cumbersome.
Furthermore, there is currently no reliable/easy-to-use, commercially available systems for managing assets (gullies).
Consequently, cleaning schedules and general upkeep of the gullies are inconsistent, inefficient and costly.

The solution: iLocator is a lean early-stage born global company, pursuing a Software-as-a-Service (SaaS) business model.
We have developed a unique platform and a range of tools to unlock a huge addressable global market, which is the effective management of gully cleaning. iLocator has clearly identified a significant potential for optimizing these maintenance processes with preliminary results indicating a reduction in maintenance and management expenses by 20%.";71429;50000;H2020-SMEINST-1-2014;SME-1;ILOCATOR ApS;DK;;; 196136;661645;IDEA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating Dishonesty with Experimental Applications: Evidence from the Lab and the Field;1/06/2015;31/05/2017;;Trust plays a very important role in economic and social interactions. It reduces transaction costs, promotes efficiency in markets, improves cooperation, and increases the ability of people, organizations and countries to adapt to complexity and change. Trust is also very fragile and can be easily break with extremely detrimental consequences for society. This highly interdisciplinary research project aims to develop a pioneer analysis of what is considered one of the most fundamental threats of trust, and, a major concern of modern society: dishonesty. The central objective of IDEA is to provide a better understanding of the determinants of dishonest behaviour by incorporates psychological, emotional and social factors that have been only recently brought into economics. Within this framework, IDEA intends to develop and test new mechanisms to fight against dishonesty which entail a lower cost for society, and preserve the freedom of citizen. More specifically, IDEA will investigate what individual characteristics are more/less likely to be associated with dishonest behaviour to provide a better understanding of deceptive behaviour, and obtain an identikit of a dishonest individual. It will examine the nexus between dishonesty and competition, in order to determine why competitive pressures induce more cheating, and which features of the competitive environment are linked to more dishonesty. By exploring the deterrence effect of information disclosure on audits and sanctions, IDEA will help to develop an optimal system of sanctions which discourage dishonesty, and minimize the monetary costs of the enforcement authority and the psychological costs of the citizens.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CLAUDE BERNARD LYON 1;FR;;; 196263;663534;VR-Suit;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;VR-Suit : MultiModal experiences in a Virtual World;1/02/2015;31/07/2015;;"Virtual worlds are an expanding phenomenon in everyday life. 3D movies are the standard in cinemas, a new television is most likely ready to show 3D television. Smartphones put nearly limitless applications in your pocket. Major tech companies like Facebook keep expanding its levels of virtual social connectivity, and takes the lead in offering social gaming. Computer games are played online, and reaching higher levels of immersion is key for developers of new games. Virtual reality goggles are on the verge of becoming mainstream, and you can even use your smartphones display as a VR goggle now.
There is one very important aspect holding back the current virtual worlds from feeling real the absence of touch.
To further increase the meaningfulness of virtual worlds, the user has to be able to physically interact with the virtual surroundings. To not only see his body movement reflected in the virtual environment, but to also feel objects and events from the virtual world in real life.
Elitac, a company specialized in tactile displays, envisions wearable technology that does just that: offer the sense of touch when roaming the virtual world. It does not matter if you are having a Skype conversation with a loved one far away, enjoying a game or movie, working through a professional training simulation or operating a complex robot being able to feel is what will enrich the experience by many times.
This proposed project is a feasibility study for a wearable virtual reality suit, for initial offering in the serious gaming market. Elitac wants to offer a product in this market, that enables the wearers to move in a virtual environment and feel objects and events by receiving tactile feedback on their skin. The study focuses on requirement analysis and technical development plans (technical feasibility) and business case design.";71429;50000;H2020-SMEINST-1-2014;SME-1;ELITAC BV;NL;;; 196090;661385;ICH-Bildung;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Impact of Intangible Cultural Heritage (ICH) in formal, non-formal and informal education and its contribution to the Key Competences for Lifelong Learning in the EU Reference Framework;1/05/2015;30/04/2017;;"Europes Intangible Cultural Heritage the skills, music, dance, drama, gastronomy, festivals, crafts, etc which have been passed from one generation to the next is a hugely important economic and social resource. Yet this aspect of cultural heritage is poorly researched. ICH-Bildung proposes to redress that balance and study the Impact of Intangible Cultural Heritage (ICH) in formal, non-formal and informal education and its contribution to the Key Competences for Lifelong Learning in the European Reference Framework.
The project will consider the wider European policy debates on Cultural Education how they can be oriented to ICH education; explore social and economic indicators to measure the impact of ICH education of both individuals and communities; and explore methods for measuring the contribution of ICH experiences to education, covering quantitative and qualitative methods, across social and economic areas.
A prestigious multi-disciplinary, international consortium has been gathered to support ICH-Bildung including: UNESCO (France) which has an ICH department; the French Centre for ICH at the World Cultures Institute (CFPCI); the Friedrich-Alexander-University Erlangen-Nuremberg, Germany (FAU) which holds the UNESCO chair in arts and culture in education; the Tartu Environmental Education Centre, Estonia (TEEC) and the Cultural Informatics Research Group University of Brighton (UoB) which provides considerable experience in the area of modelling the impact of cultural heritage. Each partner belongs to a different educational setting formal, informal and non-formal.
Modelling the impact of ICH will raise awareness about the potential value of ICH to European society and allow organisations working with ICH to gain greater clarity regarding the contribution of ICH to education and society.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITY OF BRIGHTON;UK;;; 196063;661179;MoDATS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Model-based Data Analysis of Transcription and Splicing;5/01/2016;4/01/2018;;"Gene expression is the fundamental process that in all cells produces functional protein from a genomic DNA template using a messenger RNA (mRNA) intermediate. Eukaryotic gene expression involves transcription--the polymerization of mRNA--and splicing--the removal of non-coding regions from the mRNA. Recent evidence shows that nascent mRNAs are spliced while still being transcribed, not after completion of transcription, and that splicing machinery regulates transcription. This cross-talk complicates understanding of gene expression, as its mechanism and consequences are not understood. This project proposes using model-based data analysis, applied to multiple types of data, to study the kinetics of coupled transcription and splicing.

Model-based data analysis is a statistical framework in which models are formulated as probability distributions encoding the stochastic interactions between components, including observed data. Knowledge of the underlying mechanism--here, biological--is used to quantify both the phenomenon, and the uncertainty resulting from partial knowledge and noisy observations. The need for such analysis is acute in modern biology: decades of molecular biology have yielded detailed information on specific molecules and pathways, and now next-generation sequencing (NGS) allows scientists to collect gigabytes of data on thousands of distinct molecules simultaneously. Yet, integrating these approaches is challenging: biologists struggle to analyze NGS data in ways that give insight into known--and previously unknown--biological mechanisms.

Here, the model-based data analysis paradigm will be used to interrogate the interplay of transcription and splicing, using state-of the art data including time-resolved NGS measurements of RNA processing. Working with experimentalists, we will quantify the kinetics of splicing in constitutive genes by labeling nascent transcripts, and estimate the effect of splicing on polymerase elongation genome-wide.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 196102;661472;SoWHat;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Solar Wind Heating and Turbulence;1/11/2015;31/10/2018;;Observations of solar wind (SW) turbulence have usually emphasized magnetohydrodynamic (MHD) scales where the Kolmogorov scaling f ?5/3 of the magnetic spectra is frequently observed. These spectra are thought to result from strongly nonlinear interactions. However, the question as to how turbulence of the MHD scales terminates its cascade at smaller (kinetic) scales is still hotly debated. Answering this question is indeed fundamental to understanding the processes of particle acceleration and plasma heating in the SW and in other astrophysical plasmas. This project aims at studying the mechanisms of energy dissipation in solar wind. We will use a innovative multiple approach that combines in-situ fields and particles data available from the multispacecraft missions, numerical simulations and theories to model the complex behavior of turbulence cascade at kinetic scales where it is dissipated.;264668,4;264668,4;H2020-MSCA-IF-2014;MSCA-IF-GF;ECOLE POLYTECHNIQUE;FR;;; 196060;661167;PFSEXOME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification of protein kinases and signalling pathways important for Plasmodium falciparummalaria transmission;1/04/2015;31/03/2017;;"Malaria is a devastating disease caused by the apicomplexan parasite Plasmodium. Plasmodium falciparum represents the most severe and life-threatening form of human malaria, causing over 500,000 deaths per year. There is no efficient vaccine available and resistance to all currently used drugs reported. One of the major problems in eradicating human malaria is the transmission of the parasites sexual stages, the gametocytes. These are formed in the blood and develop through five different morphological stages in specific organs of the human host. When fully mature after 10-12 days, gametocytes are released into the blood stream to be transmitted by the mosquito. The molecular regulatory mechanisms important for the formation of gametocytes are poorly understood but there is evidence showing that phosphorylation of epigenetic regulators plays a key role. The kinases that mediate these phosphorylation events and the proteins within their signalling networks, however, are not known and their identification is the aim of this proposal.

Specifically I will:

1) Develop a novel tool to enrich early stage gametocytes from parasite culture using cell-type specific surface biotinylation and affinity purification. Development of this novel technology will represent a significant enhancement in our ability to study early stage gametocytes, which are currently very hard to isolate from cell culture.
2) Identify the signalling pathways that are used during the early stage of sexual development by near-system-wide quantitative phosphoproteome analysis comparing early stage gametocytes from Aim 1 with asexual parasite stages.
3) In a complementary approach I will systematically test 10 kinase knockout lines available in the lab for their ability to form gametocytes and gametes. The function of the kinases identified will be verified by gene complementation.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE FRANCIS CRICK INSTITUTE LIMITED;UK;MEDICAL RESEARCH COUNCIL;UK; 196184;662634;ID_MOBILE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Solution to authenticate and read ID documents using mobile devices at point of origin in real-time, eliminating manual handling and providing better, more secure services.;1/02/2015;30/04/2015;;"The overall objective of ID_MOBILE is the development of a market-ready multiplatform system to verify the authenticity of identity documents by means of smartphones and tablets, based on a patent of our property and long commercial experience in the sector. This innovation will drive the change of our companys current license-based model to a Cloud-based service model as part of our plan for growth into new markets worth 300 million over a 4-year period.

At ICAR Vision Systems we have spent the last ten years providing our clients banks, hotels, casinos, telecoms and IKEA, among others with the technological edge in the automated detection of document fraud. ID_MOBILE is part of our ID Cloud platform designed to enable smartphones and tablets to reliably perform the same ID reading and verification tasks as our desktop-based systems. This will help solve client support and capture bottlenecks in sectors like Financial Services and Consumer Credit, Hotels and Resorts, Insurance, Telecom, Utilities and others that use validation to avoid identity fraud, a problem that causes losses of up to 500 billion to European companies and 20 billion to EU individuals, according to Commission estimates.

The feasibility assessment intended to be undertaken in Phase 1 covers a series of technical issues regarding the capture and processing of identity documents with mobile devices, including the choice of image capture improvement tools for development, the feasibility of facial recognition features, of manual verification modules for detected fraud and of data acquisition by streaming video. Also studied are issues related to the business plan, such as an in-depth market study of new sectors and services, IPR protection and a partner search for technology integrators.";71429;50000;H2020-SMEINST-1-2014;SME-1;ICAR VISION SYSTEMS S.L.;ES;;; 196126;661588;CARDIOTOX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Predicting Cardiotoxicity Induced by Kinase Inhibitors: From Systems Biology to Systems Pharmacology;6/12/2015;5/12/2018;;"Kinase inhibitors (KIs) are a major class of highly effective anti-cancer drugs. Unfortunately, therapeutic use of KIs is often associated with cardiotoxicity (CT), a serious adverse condition which limits their use. This fellowship aims to develop mathematical systems pharmacology models for KI-induced CT. These models will be used to identify predictive CT signatures that will allow to decrease CT risk of new KIs. This innovative multi-disciplinary approach consists of integrating mathematical systems pharmacology modelling, with state-of-the-art experimental data generation. To this aim, KIs with different magnitudes of CT will be selected based on clinical adverse event databases. Human cardiomyocytes derived from pluripotent stem cells will then be treated with the selected KIs and in combination with CT modifying drugs. The effect of these treatments on changes on untargeted mRNA and protein expression will be measured and then analyzed using network modelling. This approach allows identification of key regulatory proteins. The selected proteins will then be quantified over time along with cardiomyocyte health markers. With this data, dynamical models will be developed to capture the relationship between exposure to KIs and the effects on protein expression and cardiomyocyte health over time. Ultimately these models will allow generation of predictive network-based dynamically-weighted signatures for CT.
The fellow aims to establish himself as independent researcher in systems pharmacology. Training in state-of-the-art computational and experimental technologies at the leading systems pharmacology group at Mount Sinai in New York will fundamentally strengthen and broaden the experience of the fellow. This project will significantly contribute consolidate the career track of the fellow, foster future collaboration between Mount Sinai and Leiden University, and disseminate training in Europe.";242929,8;242929,8;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITEIT LEIDEN;NL;;; 196174;662464;RAPSODY;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Fermentation processes for functional foods from RAPeseed, Sunflower and Other EU matrices Devoted to Young animals.Zero-miles model boosting safety and competitiveness of livestock sector;1/02/2015;31/07/2015;;"In the next future, the global population growth will increase the demand for animal derived food.
The livestock sector development is a compelling societal challenges to ensure animal welfare, consumers health and the productivity and environmental sustainability of the livestock system.
To replace imported soybean and fishmeal as protein sources in the young animal dietary, RAPSODY aims at developing innovative functional foods transforming by-products derived from European agriculture (rapeseed, sunflower and other matrices) and alternative feed source (seaweeds) through the application of bio-technology based fermentation processes aimed at: 1) increasing digestibility, 2) enhancing/balancing the amino acidic profile of the starting matrix.
Compared to Soy Protein Concentrate and fishmeal, the benefits associated with the new products are:
- Safer, cost-effective natural products for animal feeding, reducing harmful substances and synthetic additives in the final food;
- Minimize imports, strengthening European self-sufficiency for the livestock sector
RAPSODY will also provide an innovative business model for the production and commercialization of the final functional foods according to a zero-miles system, by localizing small productive plants near raw materials suppliers and final users. The model will boost the competitiveness of the livestock sector: the superior quality in terms of nutritional value and final food safety, together with competitive prices with respect to SPC and fishmeal, will allow the new products to acquire the 35% of the swine market share within 5 years, generating an annual turnover of 150 million euros/y.
The feasibility study will allow
- The definition of the preliminary layout for the demonstration plant
- the development of strategic partnership
- The definition of the commercial strategy and marketing plan
- to verify the economic sustainability of the envisaged business model
- to outline of the most effective IPR management.";71429;50000;H2020-SMEINST-1-2014;SME-1;METHODO CHEMICALS SRL;IT;;; 196084;661369;NanoMATe;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanoparticles for Molecular Imaging of Atherosclerosis: from Diagnosis to Treatment;1/09/2015;31/08/2017;;"Atherosclerosis is a disease of the arteries. It leads to the formation of atherosclerotic plaques (atheromas), which may disrupt the blood flow to target organs, leading to heart disease and stroke - the most common causes of death in developed countries. Cardiovascular imaging has traditionally focused on the anatomy of the atherosclerotic plaque; however, the degree of vessel narrowing caused by the plaque isnt the only characteristic that can determine the clinical outcome. Indeed, the cellular and molecular composition of the atheroma can indicate whether the plaque might cause complications. In particular the local immune-inflammatory response participates from the onset of the pathology through its progression, up to clinical manifestations. Consequently the development of innovative approaches for the molecular imaging of inflammation in atherosclerosis would be key to improve diagnosis and treatment.
In the last decade molecular imaging has emerged as a novel tool for the visualization and measurement of biological processes in atheromas. Various imaging technologies have been developed; however, each approach presents severe weaknesses. Surface Enhancement Raman Spectroscopy (SERS) is developing as an effective molecular imaging optical modality in biomedicine because it offers many advantages over traditional technologies, including better sensitivity, and a superior multiplexing capability. Therefore, the primary aim of the present proposal is to develop innovative, highly-sensitive and selective but relatively affordable SERS-based system to measure inflammation in atherosclerotic vessels. I will use nanoparticles (NPs), small metallic particles, which possess the ability to recognise inflammatory markers, as imaging probes. When a light source is shone on these NPs, they can be detected by SERS. The secondary aim is to customise the NPs to enable local treatment of the pathology. The proposed approaches will offer new ways to manage atherosclerosis.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 196092;661396;ITER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Improving Thermal Efficiency of horizontal ground heat exchangers;1/11/2015;31/10/2017;;"Since heating and cooling demands constitute almost 50% of the final energy demand in Europe, the development of geothermal energy systems and especially shallow geothermal solutions, reveals a huge potential in providing thermal energy for residential and tertiary buildings, thanks also to its local availability, manageability and flexibility. Then, research and innovation actions in this topic are focused on finding new technical solution, developing emerging technologies and improving heat transfer efficiency of existing systems. There is required, on the one hand, a better knowledge of the thermal properties of the ground and, on the other, the efficient implementation of thermal energy transfer technologies.
ITER Project (Improving Thermal Efficiency of horizontal ground heat exchangers) totally agree with these purposes. In fact, the overall aim of ITER is to ensure the sustainability of ground coupled heating-cooling systems and especially the horizontal ground heat exchangers systems. Key challenges are (i) to enhance the heat transfer of the ground surrounding the pipes creating thermally enhanced backfilling material (TEBM) suitable for horizontal systems; (ii) to assess the performance and the environmental impacts of new promising technological solutions as helix systems with and without TEBM; (iii) to monitor the results over time through direct measurements and numerical simulation.
Thermal laboratory measurements and in situ monitoring of existing and duly installed horizontal systems will be provided by close cooperation between host institutions and non-academic partners. Projects and ideas challenging a better performance of shallow geothermal plants as those promoted by ITER are expected to support the European economic growth and technological excellence, boosting competitiveness and job creation, taking into account also the individual and collective well-being of citizens, protecting the environment and, accordingly, the human health.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Friedrich-Alexander University (FAU) Erlangen-Nrnberg;DE;;; 196217;662967;SmartDesalt;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Smart Pressure Vessel for water desalination with reverse osmosis membranes;1/02/2015;31/05/2015;;"The United Nations predicts that by 2025 two-thirds of the world's population will suffer water shortages, especially in the developing world and the parched Middle East. In Europe, water is also a major concern in countries that fall under the Mediterranean basin such as Spain, Italy, Turkey, Greece, France and Israel. Fresh water is required not only for drinking and domestic purposes. Industry accounts for nearly 60% of fresh water withdrawals in the developed world and agriculture consumes 70% of fresh water supplies globally. Consequently, an adequate supply of good-quality water is a pre-requisite for economic and social progress, and competition for water poses a growing risk to the economy, communities and the ecosystems they rely on.

The growing need for water in the world will be met in a large part by desalination. Governments and industries no longer look to desalination as a secondary, but as a primary alternative to increase water supply for domestic, agriculture and industrial use in the world, and especially in the Mediterranean basin and the Middle-East, the target locations for SmartDesalt.

Among desalination technologies, reverse osmosis based desalination is the most popular because it is the most energy efficient. However, costs are still the largest barrier for its implementation.

ROTEC, an innovator in commercializing technology to prevent scaling in membranes and pipes, has joined forces with BEL Composite Ibrica, world-leader in pressure vessels (membrane housing) for water desalination systems, to exploit a joint business opportunity. They will develop a new generation of smart pressure vessels which allow the direct on line measurement in real time of the process flow inside the vessel. This allows the detection and identification of early stages of fouling formation (by type, biofouling or mineral scaling, and location on the membrane surface) so that a preventive maintenance strategy can be more efficiently implemented. Such a stra";71429;50000;H2020-SMEINST-1-2014;SME-1;ROTEC - REVERSE OSMOSIS TECHNOLOGIES LTD;IL;BEL COMPOSITE IBERICA SL;ES; 196121;661555;PAOLInA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Physical Activities of Older Adults: Longitudinal Interdisciplinary Analysis;1/03/2016;28/02/2018;;The PAOLInA-project focuses on physical activities of older citizens of European countries. It begins with the analysis of the phenomenon physical activities, and their change in the course of the late and latest years of life. The goal is to show what is covered by the term physical activities (PAs), and to differentiate PAs into domains according to their purpose (e.g. sports in leisure time, PA for self-care, PA as form of transportation). The Experienced Researcher (ER) hypothesizes that the overall involvement of older adults in PA does not necessarily decline as the individuals are getting older, but that some types of activities may even increase or replace others. If these interdependencies are neglected in the measurement older adults may appear as more sedentary than they actually are. The ER will also examine the factors that influence the change of the PAs. She will look at the interplay between individual characteristics and the attributes of peoples living environments. As a result, patterns of PA promoting factors will be carved out. The research will be based on secondary analysis of various longitudinal data sets, such as the German Socioeconomic Panel (SOEP) and the Survey of Health and Retirement in Europe (SHARE). Multilevel modelling will be applied in the statistical analyses. Thus, the PAOLInA-project is innovative in several respects: It will differentiate the PAs, which according to the state of the existing research has rarely been the case. It will reveal the long-term developments in older adults engagement and involvement in PAs. It will match individual characteristics with environmental and regional indicators. The ER will introduce her perspective of health psychology into an institute that does not have this specialization yet. She will benefit from the excellent methodological expertise of her prospective supervisor, additional training and support from the partners, and get access to a European network of collaborators.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HUMBOLDT-UNIVERSITAT ZU BERLIN;DE;;; 196074;661249;GESTATE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;testinG massivE STar formATion modEis;1/05/2015;30/04/2017;;"The classic problem in the formation of high-mass stars is that, for all stars above ~20 Msun, the outward force exerted by the stars radiation on the dusty circumstellar gas should be capable of reversing or halting accretion flows. Core fragmentation, pressure from the expanding ionised gas, magnetic fields and mass loss through stellar winds, all work against the effects of gravity, thereby restricting the final stellar mass. Advances in theoretical models, aided by numerical simulations (e.g. adaptive mesh refinement), have proposed elegant solutions; for example, the interaction between radiation and the dense circumstellar gas is subject to radiation-Rayleigh-Taylor instability, creating low opacity chimneys to vent out the radiation pressure. Likewise, heated cores and disks are stable against Jeans fragmentation. The exact manifestation of these issues and their solutions vary significantly between theories, and the physical structures found around embedded, still accreting massive stars provides a strong discriminator between models. Therefore, this research project aims to better understand the physical conditions of the gas and dust structures within the 500-5000 AU regions of infant high-mass stars by using adaptive-optics-assisted polarimetric observations in the infrared (essential to probe through the high extinction of high-mass cores). Also, we will characterise and quantify, for the first time, the stellar activity, mass, and radius of high-mass (young/proto) stars which are thought to be bloated and pulsating objects. To this end, variability and astero-seismological studies will be conducted. The applicant seeks mobility to a host institute that is a world leader in polarimetry, where he will acquire new expertise in astrophysical polarimetry through training by research. This program will distinguish between and test mechanisms of massive star formation, taking important steps to understand a long standing problem of astrophysics.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;The University of Hertfordshire;UK;;; 196230;663108;Free power supply;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Stand-alone power supply saving low-speed fluid energy available around us;1/12/2014;30/04/2015;;"The project is about designing, manufacturing and marketing a range of stand-alone power supply products based on pico-turbines able to efficiently produce on-line and deliver the few tens to hundreds of watts needed by the process and quality control equipment of the water supply networks.
Indeed, so as to limit the Non-Revenue Water (35% NRW in average worldwide ) and to reach the expected service quality, sensors as well as regulation systems and signal transmitters are increasingly installed at the innumerable junctions of the water distribution networks.
Beyond those needs, there are several similar industrial stand-alone power needs which can be fulfilled by our breakthrough technology, like for industrial fishing monitoring equipment, irrigation monitoring systems, sailboat on-board safety and comfort equipment or weather marine station and buoy networks equipment, all being of global reach.
Thanks to its partnerships with public research labs (Polytechnique Grenoble, CNRS) and experts (Prof. M. Jufer, EPF Lausanne), as well as 3 years of technical development, Save Innovations designed its first innovating pico-turbine, which is intrinsically waterproof, simple (5 main components), requires no specific maintenance and produce at flow speed as low as 0.5m/s. 4 Patents are published, and 5 new patents have been applied.
A first set of prototypes have been successfully tested in a relevant environment.
Feasibility within the breadth of the water network requirements as well as product range analysis is now needed before heading to the standard product development and industrialization (will trigger a phase-2 request).";71429;50000;H2020-SMEINST-1-2014;SME-1;SAVE INNOVATIONS;FR;;; 196048;661092;STRETCHLENS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deformable platform with thin-film based circuits and ultra-thin Si chips for smart contact lens applications;1/09/2016;31/08/2018;;"A smart contact lens is a device in direct contact with the eye, having integrated electronic functionalities in order to improve the well-being of the user. In that respect, these devices are envisaged to address diverse complex aspects, such as providing augmented reality, performing biomedical sensing and correcting or improving vision. For the first two application areas, possible approaches have already been demonstrated. However, the use of smart contact lenses to correct vision has only been recently proposed through the help of integrated liquid crystal (LC) cells. The integration of these LC cells in a contact lens is in particular appealing for ophthalmological disorders like iris perforation and presbyopia; the latter alone affecting more than 1 billion people. The STRETCHLENS platform envisages the hybrid integration of electro-optic capabilities (e.g. LC cells), RF transmission (e.g. antenna, ultra-thin Si chip - UTC), specific biomarker sensing (e.g. to identify some types of cancer cells) and thin-film based stretchable electrical interconnections. The platform, besides being stretchable due to the spherical shape of eye and manipulations during insertion/extraction of the lens, will incorporate novel 3-D electrical interconnections which will allow for multilayer metallization to integrate UTCs, minimizing surface area and greatly improving miniaturization. Furthermore, the project will develop new knowledge through technological advancement and models of adhesion/cohesion at the interface of hard/soft composites, in order to predict delamination failures and optimize assemblies through design. The completion and development of such highly integrated stretchable systems will open up diverse research opportunities in the fields of biomaterial science, stretchable micromechanics, and autonomous biomedical and conformal electronics smart systems.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;;; 196101;661452;EPI_nanoSTIM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Enabling motor control after a spinal cord injury through nanoscaled electrical;1/10/2015;30/09/2018;;"A spinal cord injury (SCI) has consistent social costs, due to dramatic and disabling consequences and a high incidence on the youngest and most productive population, which can hardly be alleviated by the very few and controversial therapeutic treatments. In a recent case report, epidural electrostimulation combined with an intense training enabled some highly variable conscious motor control of legs in four motor complete spinal cord injured volunteers. The aim of understanding the mechanisms behind these improvements can help define more effective pharmacological and electrical stimulating protocols with breakthrough technology to restore functions after a SCI. Experiments will be performed on adult rats, with an experimental SCI closer to human chronic lesions, on which I will apply the novel enabling protocol with epidural electrostimulation associated with an intense motor training. Outcome will be evaluated with innovative combinations of electromyographic and kinematic assessments of locomotion and standing posture, in vivo terminal intracellular recordings from lumbar motoneurons and histological examination of spared axons across the lesion. Then, I will employ carbon nanotubes to devise nanostructured innovative stimulation arrays for a more specific and focussed epidural stimulation to enhance recovery.
The unique experience of Prof. Edgerton and Prof. Ballerini will allow me to acquire new skills on both preclinical SCI models and assessments and nanotechnologies, to increase my international collaborations, support my research through greater funds and a new in vivo research line, with the aims of obtaining a professorship and a greater visibility in the field. The project is deemed to advance and diffuse scientific knowledge and further sustain European competitiveness, through two patents on discoveries with a great commercial impact and possible clinical applications to reduce healthcare expenses.";262269;262269;H2020-MSCA-IF-2014;MSCA-IF-GF;SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE;IT;;; 196045;661067;HotCoalgebras;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Homotopy theory of cosimplicial unstable (co-)algebras over the Steenrod algebra;1/05/2015;30/04/2017;;"This research proposal is in mathematics, its content is part of algebraic topology and homotopy theory. It aims at deepening our understanding of the homotopy theory of cosimplicial unstable (co-)algebras over the Steenrod algebra and its relation to the homotopy theory of cosimplicial spaces. This is achieved by new methods developed recently by the ER (Dr. Biedermann) and coauthors and by methods from Goodwillie calculus. Specifically, there are three closely related parts/work packages:

1. Prove a general vanishing theorem of higher obstructions for realizing a map on homology as a map of spaces. The theorem is known to hold in rational homotopy and in the mod p Massey-Peterson case.

2. Find an algebraic description of the first obstruction living in Andre-Quillen cohomology (AQC) to the existence of a realization of unstable coalgebras.

3. Define natural operations on AQC of unstable coalgebras with general coefficients.

As part of the risk management we describe two further fallback projects:

4. Study the Goodwillie tower of the identity functor of simplicial unstable algebras and relate its layers to AQC.

5. Describe the algebra of homotopy operations on simplicial commutative algebras for odd primes p.

These projects are parts of a program of the ER to investigate realization problems and rigidity results associated to singular (co-)homology. A longterm goal (beyond the time frame of the fellowship) is to develop a deformation theory of unstable (co-)algebras over the Steenrod algebra and their realizing homotopy types in the mod p case.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PARIS 13;FR;;; 196238;663196;ModeCore;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Muli-path optical fibre modules;1/02/2015;31/07/2015;;"The business concept is to provide advanced optical fibre components, modules and sub-systems utilising advanced, new fibres; few mode fibre (FMF), multi-core fibre (MCF). Sensing systems based on these new fibres and space division multiplexing (SDM) systems, for enhancing future network capacity, are being developed, but the problem is that there are no commercially available component products to build these systems.

The project objective is to develop a range of optical fibre component, module and sub-system products for FMF and MCF solutions in network and sensing applications. Basic building block components and fully integrated multiplexers and amplifiers for high channel count systems will be developed.

Demand for components utilising these new fibres is continuing to increase and technical specifications are developing. Within this project Phoenix will have the resource to work with the customer, to develop a required specification of product and supply to the customers needs.

The feasibility assessment will enable a full commercial assessment to be made. Current technology status, competitive landscape, operator forecast and customer requirements will be assessed. Potential partners and sub-contractors to develop the suite of products will be identified and a roadmap with route to market will be defined.

The market is global and this project will provide the opportunity for a European SME to be at the forefront of this key future technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;PHOENIX PHOTONICS LIMITED;UK;;; 196159;661916;Project Sense;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Enforcement of the environmental regulations on sulphur emissions from ships using drone technology.;1/02/2015;31/07/2015;;"Explicit I/S is seeking phase 1 funding in order to assess the commercial feasibility of Project Sense ? a drone technology system to monitoring sulphur emissions from ships during cruise.

Project Sense is aimed at offering a cost-efficient, highly scalable solution in answer to the urgent demand by enforcement authorities (= customers) for technologies to enforce the international restrictions on ship sulphur emissions in force from 1 January 2015. On this date, the allowed sulphur limits in North European and North American waters will be reduced by 90 % resulting in a dramatic increase in fuel costs for ships operating in these areas. If not effectively enforced, the change threatens to create a devastating competitive disadvantage to those operators - many of them European - who comply with the rules. Creating a difference in market pricing of up to 25-30 % the temptation to keep burning high sulphur fuel will be enormous.

But ship emissions are hard to monitor and existing sampling technologies are limited and very costly to deploy. Project Sense solves the enforcement challenge by using smart, self-guided drones programmed to intelligently seek out the ships at sea, sample the plumes using onboard sensors, and transmit the compliance results back in real-time. Based on low-cost hardware components tied together by an advanced software platform proprietary to Explicit I/S, Project Sense presents a highly competitive enforcement alternative to the authorities in Europe and globally.

The feasibility study is intended to assess the commercial viability and marketability of the prototype system. In particular: The regulatory requirements needed to operate autonomous drones in the key markets; optimising the software for smart flight and establishing key operational parameters; verifying the appropriate business model; and exploring grounds for extended IPR. The study will lead directly to a Phase 2 application to take the project into scale.";71429;50000;H2020-SMEINST-1-2014;SME-1;EXPLICIT IS;DK;;; 196106;661484;COSMOS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Optical point of care system for heart failure mass screening;4/05/2015;3/05/2017;;"Diseases of the heart and circulatory system are the main cause of death in Europe (over 4 million deaths each year). In particular, heart failure (HF) accounts for almost 1.1 million deaths each year.
In early 90 there was the formal recognition that inflammatory mediators are activated in the setting of HF by a sentinel description of inflammatory cytokines in patients with heart failure. After that, a growing interest in the role of biomarkers in regulating cardiac structure and function, particularly regarding their potential role in disease progression in heart failure, raised up. Nowadays, there are evidences on that.
Generally, biomarkers are determined mostly in plasma or in blood, rather than in saliva. In fact, despite of that very few of them have been currently studied in saliva, saliva has to be considered as an important diagnostic and prognostic medium for minimally invasive tools. Indeed a great progress in disclosing the complete salivary proteome has carried to the identification of more than 3000 different proteins.
Scope of this project is to develop a tool for HF-biomarkers detection through saliva. The idea is to combine the knowledge of the experienced researcher in microelectronics and CMOS imagers with the competences of the hosting laboratory on bioMEMs for biomarkers immobilization to develop an innovative point-of-care system for a fast and precise detection of HF-biomarkers. To this end the hosting institution and the experienced researcher complete each other and make the research and development on this cross related filed feasible. The proposed device will allow a mass screening for the prevention of HF and other pathologies related to the cardiovascular system.
Within this project, the experienced researcher will be able both to enlarge her knowledge in the design of CMOS imagers by implementing innovative photon detection techniques and to approach a growing branch of microelectronics, such as the bioMEMs one.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CLAUDE BERNARD LYON 1;FR;;; 196202;662786;FreshInk;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Colour-code labelling for continuous monitoring of quality and safety of packed chicken meat;1/03/2015;31/08/2015;;"Every year, approximately 30 million tonnes of food is wasted in Europe because it was not consumed before the expiry date. Currently, expiry date labels do not provide an accurate indication of the foods freshness, instead reflecting the worst case scenario of how long a product should be safe to eat. FRESHINK is an ink product that changes colour as the foods freshness status changes, allowing consumers to make decisions on whether to eat or dispose of the product, based on the real freshness status of the food.

CHIMIGRAF are an SME dedicated to the production, distribution and sale of liquid flexographic inks for the printing industry and the developers and owners of FRESHINK. They have developed and validated FRESHINK in the Spanish national project SENSOPACK. They now propose to use a phase 1 SME Instrument to confirm the market potential of FRESHINK labels, specifically targeting the market segment of packaged chicken breasts.

The project will seek to i) validate the ink formulation and printing conditions at industrial scale, ii) test the label in real life conditions of packaged chicken breast meat, iii) engage consumers and stakeholders to validate market acceptance, iv) develop a comprehensive investor ready business plan.

The outcome of the project will be a series of identified technical and market related challenges, and a strategy to overcome them, that must be completed by CHIMIGRAF in order to successfully launch the FRESHINK labels in the packaged chicken breast market. It is anticipated that achieving a market penetration of 5%, five years after the project has finished will earn CHIMIGRAF a profit of approximately 6.5 million Euros, and will help reduce European food waste by 25,000 tonnes annually.";71429;50000;H2020-SMEINST-1-2014;SME-1;CHIMIGRAF IBERICA SL;ES;;; 196077;661315;TOPOZOO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Free-standing three-dimensional topological structures in geometrically confined chiral nematic liquid crystals: fundamentals and applications;1/01/2016;31/12/2017;;"This two-year project aims at exploiting both the intrinsic robustness and wide diversity of topological structures that naturally appear in soft condensed matter systems such as liquid crystals in order to fabricate advanced materials, possibly reconfigurable, towards emerging photonics applications such as high-dimensional data storage and topological shaping of light at small scale.

Our proposal basically relies on the use of geometrically confined chiral nematic liquid crystals that have been theoretically predicted to exhibit a rich variety of distinct metastable topological defects. Our ambition is to establish the related experimental foundations, to develop techniques for on-demand reconfiguration the generated topological structures, and to bring proof-of-principle of a few applications that we foresee. To this aim, the project will focus on one of the simplest case, namely the case of spherical microscopic droplets.

The required scientific expertise and experimental facilities for successful completion of the project mainly cover the physics of liquid crystals defects, field-induced reorientation of liquid crystals and the topology of light fields. This will be ensured by the long-standing experience of the Supervisor as well as broad experimental capacities of the host group whereas present skills of the Researcher in the physics of liquid crystals and molecular photochemistry in confined media guarantee an efficient start of the project.

Since the research topics of this proposal are encompassed in the global scientific policy of the host University, this project offers a unique opportunity to initiate perennial cooperation between the Researcher the host University. The successful implementation of the project will therefore be beneficial both to Supervisors research group and to Researchers career, who aims at obtaining a permanent position and eventually leading her own research group.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit de Bordeaux;FR;;; 196111;661505;HumEnBody;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Responding to the Trend of Human Enhancement Drugs: the Case of Drug-Free Bodybuilding Culture in European Context;1/09/2015;31/08/2017;;The present project sets out to explore the hitherto uncharted culture of drug-free (natural) bodybuilding that has been emerging in different parts of the world as a response to a dominant, pharmacologically-enhanced model that has thus far monopolised public attention and debate. My aim is to critically investigate the practices, discourses and structures that constitute natural bodybuilding and make sense of it in light of a ubiquitous gym/fitness culture and the wider phenomenon of human enhancement. Focusing on Europe as a significant and intriguing site in this emerging global mosaic of body cultures, the research will employ a combination of qualitative methods to trace the development of natural bodybuilding across diverse geo-cultural areas of the continent.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 196070;661210;METAPHOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;People, Space and Time: Understanding metaphors in sustaining cultural landscapes;1/07/2015;30/06/2017;;"Growing up near Great Zimbabwe, I was always fascinated by the myths and legends associated with the site. However it was surprising that these stories never featured in my studies as an archaeology student. This essential contradiction is at the root of this project which seeks to address the significance of these myths and legends in understanding and managing cultural landscapes. More specifically its aims are to 1) map sacred landscapes through metaphors represented by myths, legends and folklore linked to the two places chosen as case studies; 2) explore how metaphors sustain sacred cultural landscapes in traditional societies in Zimbabwe and Australia; and 3) examine how metaphors can be useful to archaeological research, the management of heritage places and ethical heritage practice. In this study, metaphor is the language used in defining certain elements of the landscape through stories by communities that revere them. Through this understanding, sites and artefacts are anthropomorphised to behave like people and to take physical characteristics of humans. The project utilises two sites as case studies: Great Zimbabwe (Zimbabwe) a cultural site revered by Shona communities living near it, and Uluru a natural landscape on which local Aboriginal communities have inscribed culture through metaphors. The study will have a practical purpose: understanding metaphor by both experts and other users to create new interpretations of sacred landscape that can reduce conflicts with communities that inscribe cultures on the landscape . I argue that to understand landscapes that are sacred, one has to understand the cultural and environmental metaphors of those communities that own them. Current approaches tend to divide landscapes into natural and cultural but emphasizing this separation fails to understand the investment communities have in landscapes. This research seeks to redress this imbalance, and emphasise ways of drawing this approach into the mainstream.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of York;UK;;; 196248;663392;D-Orbit;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Smart propulsive device for controlled satellite reentry and reorbit.Type of funding scheme: SME Instrument;1/02/2015;31/05/2015;;"Space is getting crowded, with more than 300 million junk and 6000 satellites of which only 1100 are still operative. Today space activities are not sustainable: if the increasing defunct satellites in orbit are not quickly disposed, the risk predicted by NASA of chain collisions destroying the whole satellite classes around the Earth will become real. Over the next years the satellites failure probability due to collision with fragments will show the greatest increase. The overall impact of human-made orbital debris, solid and liquid propellant discharges, the chemistry involved in the heating during reentry of space leftovers greatly affects Earth's stratosphere and atmosphere.
In this scenario, D-Orbit aims to offer a Decommissioning Device that will be able to meet the requirements of international guidelines and regulations and the demand of space operators for an affordable and reliable technology for managing the end-of-life of space assets that permit the full exploitation of satellite lifetime, and the cost decrease for decommissioning operations. D-Orbit developed a smart propulsive device capable of standalone operations that can be installed into satellites and re-orbit GEO and MEO satellites into a graveyard orbit at the end-of-life, or to bring LEO satellites back through the atmosphere in a quick and controlled manner leading either to safe destruction or to fall down into a predicted area, avoiding collisions with other operating spacecrafts or falling uncontrolled into critical assets and people on Earth.
For telecommunication satellite operators, an increase of revenues up to 25 M can be envisaged, just considering the increase of lifetime permitted by the use of the device. The company will cooperate together with potential customers (satellite operators and manufacturers) in order to accelerate the technology adoption and foster compliance with worldwide regulations/guidelines in space debris matter.";71429;50000;H2020-SMEINST-1-2014;SME-1;D-ORBIT SRL;IT;;; 196169;662453;ColdPeak;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;PCM-based cold storage as peak shaving for air conditioning units;1/01/2015;31/05/2015;;"The project deals with the design, customization, fabrication and testing of an innovative Phase Change Material (PCM) based cold storage system, able to store cold energy as liquid/solid latent heat of a proper material and based on a patent recently developed by Upgrading Services.

Thanks to the high charge/discharge cold power of the proposed storage technology due to an innovative heat exchanging strategy, ColdPeak device can be integrated in a Air Conditioning (AC) system as a peak shaving able to:
1- reduce the chiller size and, consequently, its market cost (-20%);
2- allow an almost constant operation of the AC system at its optimal power in terms of COP, improving the system efficiency (\20% at least).

Moreover, charging the storage during night hours, when the electricity cost is lower and the outdoor temperature (wet bulb temperature) is colder, the chiller production COP is further improved.

The feasibility study performed in Phase 1 will provide a business plan to reach commercialization, including a market study, risk analysis, economic and financial analysis, outlining the business concept and confirming it offers a viable solution to improve AC systems performance. The study will confirm any IPR issues and create a Consortium including agreements with a HVAC manufacturer and a PCM producer.";71429;50000;H2020-SMEINST-1-2014;SME-1;UPGRADING SERVICES SPA;IT;TEP ENERGY SOLUTION SRL;IT; 196033;661019;TransVivome;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Microbial biogeography of the gastrointestinal tract: Towards a better understanding of the drivers of oral and colorectal cancer development.;1/04/2015;31/03/2017;;The human microbiome plays essential roles in modulating human health and disease. Based on preliminary data as well as previously published work, I hypothesise that 1) the oral cavity acts as a reservoir of microbes which continuously seed the gut and that 2) specific aberrations of the microbiota along the gastrointestinal tract (GIT) are linked to the development of colorectal cancer (CRC) and oral cancer (OC). My aim is to test these hypotheses through an integratation of metagenomic and metatranscriptomic data generated from microbial consortia in the colons/recta as well as oral cavities of patients with CRC or OC, and compare these to healthy individuals. Successful completion of the project objectives would address the questions: which microbial strains survive passage from the oral cavity in to the gut? Does the mouth act as a reservoir for strains driving CRC development? And can a panel of multi-factorial biomarkers outperform current CRC and OC diagnostic standards?;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;;; 196086;661342;NEARCONTROL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;NEARshore geological CONTROL on coastal morphodynamics: monitoring and modelling in high-resolution;1/02/2016;31/01/2019;;A major shortcoming of contemporary coastal research is the poor quantification of geological control in nearshore hydrodynamic and morphosedimentary processes along natural and developed coastal areas. This is particularly relevant given the global dominance of geologically-constrained coastlines, which face increasing risks driven by extreme storm events and growing societal pressures on the coast. This project aims to advance the knowledge of beach and nearshore morphodynamics within complex geomorphological settings, dominated by multi-dimensional geological control. The fundamental objective is to quantify the role and impact of nearshore geological control under energetic conditions. This will be accomplished by developing a ground-breaking approach, based on state-of-the-art surveying and monitoring methods to acquire unprecedented geophysical, morphological and hydrodynamic information of the beach and nearshore zones in geomorphological complex settings. New-generation process-based modelling will be implemented to explore wave-driven currents and patterns of sediment transport under realistic settings and conditions. Linking the sedimentary and geological framework of the beach and nearshore with field measurements and numerical modelling constitute a novel approach that will lead to fundamental advances in coastal geomorphology, further improving the ability to predict storm-induced erosion in geologically-controlled settings. To bring together these embedded scales of analysis and innovative approaches, this project is based on collaboration with international-leading experts in coastal geomorphology, marine geology and geophysics and coastal modelling. Expertise and skills developed by the fellow will contribute to an internationally-leading academic and research profile, promoting European research with global collaborations.;203200,2;203200,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY OF ULSTER;UK;;; 196087;661401;KINSELECT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Microtubule organisation and polarized transport of kinesins in neurons;1/05/2015;30/04/2017;;The human brain consists of intricately connected neurons forming functional circuits encoding memory, emotions and cognition. A neurons polarized organisation into axons and dendrites underlies its ability to receive, process and transmit information. To establish and maintain such a highly complex organisation, cytoskeletal motor proteins transport basic building blocks to either axons or dendrites. Several members of the kinesin motor family are selectively moving into axons, presumably guided by the specific organisation of the neuronal microtubule cytoskeleton. However, how different aspects of microtubule network organisation, such as filament length, orientation and modifications, contribute to selective transport of these kinesins is poorly understood. Therefore the aim of this project is to determine the connection between neuronal microtubule organisation and polarized transport of different kinesins. We will map the three-dimensional microtubule network at nanoscale resolution (objective 1) and decipher the intracellular transport driven by kinesins with optogenetics (objective 2). The integrated and quantitative knowledge provided by this project will pave the way towards understanding polarized transport in health and neurodegenerative diseases.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 196215;662957;SPARK;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Cost-effective automated process for producing innovative high-performance electric motors;1/03/2015;31/08/2015;;"DEMA is a high-tech SME, world leader of machines for the production of electric motors. We have developed a new manufacturing process and associated machinery enabling production of the emerging segmented motors, where stators and rotors are composed by modules (segments). Compared to traditional motors the segmented ones are:
cheaper, because use of raw materials is more efficient and assembly is simplified,
greener, because waste material during production is massively reduced,
high-performance, thanks to optimization of electrical phenomena.

The segmented motors, whose production is enabled by SPARK, meet the needs of motors manufacturers for reduction of waste material in production, due to cost and environmental concerns.

SPARK strongly supports the EC Societal Challenges for clean, efficient energy, environment, resource efficiency and raw materials. Segmented motors, in fact, reduce wastes and therefore energy, CO2 and pollution for material recycling and re-processing.

The feasibility assessment will focus on the production process and machinery; the goal is twofold: the technical feasibility (to assess what are the necessary developments to be carried out and including an IP regime analysis) and the economic viability (a detailed Business Plan will be built around the 9 classic blocks of Canvas). This would allow to consider the additional funding that will be needed, with a possibility to further develop the concept through a Phase 2 project.

Overcoming the technical barriers in manufacturing these motors, implementing an advanced manufacturing process and introducing the related machinery in our product portfolio by end of 2017 is our major objective. If we succeed in developing this, we would be the only company providing this solution, anticipating competitors, penetrating the market and achieving high market shares. This will improve and consolidate our position in the market of automated machinery for motors production.";71429;50000;H2020-SMEINST-1-2014;SME-1;DEMA SRL;IT;;; 196030;661009;HUMANITECH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Humanitarian Technology Interventions;1/09/2015;31/08/2017;;There is growing global interest in the positive role of technology (such as mobile phones, sanitary toilets, or malaria nets) to alleviate problems associated with poverty and humanitarian crises. However, research on humanitarian technology interventions is overly technology-centric, focusing on issues of design, production, delivery, and efficiency. This research project will advance the study of humanitarian technology as an organisational phenomenon with the dual objective of advancing scholarship and informing intervention policy and practice. Specifically, the research project will explore three multi-level phenomena associated with humanitarian technology interventions: the role of rhetoric in establishing international technology standards, global organizing of interventions, and the experiences of user-beneficiaries. These will be explored through the following research methods and modes of analysis: case study design, dramatism, narrative interviews, and thematic analysis. Scholarly innovation and expertise will be realized by advancing and applying the research methodologies of dramatism and narrative interviews to study humanitarian technology interventions.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ERASMUS UNIVERSITEIT ROTTERDAM;NL;;; 196059;661163;Coastal Hypoxia;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Disentangling anthropogenic and natural causes for global coastal hypoxia;1/06/2015;31/05/2017;;Dissolved oxygen is an essential substance for a large portion of marine biota. Hypoxia, the reduction of dissolved oxygen concentrations to levels which are detrimental to the health of aerobic organisms, is currently expanding throughout the world's coastal areas, creating a negative impact from both the environmental (e.g. reduced biodiversity, reduced population growth, formation of 'dead zones') and economical (loss of fisheries) perspectives. Through the development and usage of local to global scale biogeochemical models, this research addresses past, present, and future formation of hypoxic 'dead zones' as a result of human-induced nutrient loadings and climate change. These topics are relevant for both industry and society, as they include the effects of changing river nutrient export to coastal marine ecosystems on the increasing frequency, extent, and duration of hypoxia. These studies will serve to further constrain nutrient reduction strategies and their effect on the amelioration of hypoxia in various coastal environments.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 196223;663055;GRAPHEEN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Green and Straightforward process for the synthesis of Graphene based-nanomaterials for energy applications;1/02/2015;31/07/2015;;"GRAPHEEN project aims at scaling up a green, affordable and straightforward process for the industrial synthesis of graphene-based materials for their use as new electrode materials in higher performance electrochemical energy storage devices: lithium ion batteries and supercapacitors.

Lithium Ion batteries (LIBs) are currently dominating the energy storage market, as they are to date best performing devices in terms of energy storage capability (energy density). However, LIBs are still facing challenges because they lack of a high power density, meaning these devices have long charging/discharging cycles. This issue is especially important in view of efficiently exploiting renewable energies and especially for supplying the required energy to power electric vehicles (when high energy inputs are required in a very short time). As alternative, supercapacitors emerge as alternative to Lithium Ion batteries because these devices can provide high energy inputs in just a matter of seconds because of their high power density. Nevertheless, in contrast with LIBs, supercapacitors cannot accumulate enough energy to supply during a long time (they have a low energy density). For these reasons, supercapacitors and LIBs are being used as complements one of each other in those highly energy demanding applications. In view of the rapid market entrance of electric vehicles and the big pressure towards using alternative energy sources to fossil fuels, the energy sector is facing an increased need for solutions to enhance the power density of LIBs and to improve the energy density of supercapacitors. The solution to achieve these improvements is the development of new and better performing electrode materials, as the performance of electrochemical devices mostly relies on the properties of the electrodes integrating them.";71429;50000;H2020-SMEINST-1-2014;SME-1;GNANOMAT SL;ES;;; 196142;661678;RiceStyle;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Carpel evolution: a walk in the rice side;1/01/2016;31/12/2018;;Flowering plants (angiosperms) protect their female reproductive structure, the ovule, within a carpel. After the embryo sac in fertilized by the pollen tube, the ovule gradually turns into a seed, and the carpel becomes a fruit. The carpel is thus an evolutionary conserved structure, but showing an outstanding variability in shapes and function. Several transcription factors directing the main aspects of carpel formation and morphogenesis, are quite well characterized in the model eudicot plant Arabidopsis thaliana. More recent evo-devo studies suggest that some of these transcription factors are functionally, conserved, at least in eudicot plants. However, this knowledge is far to be complete, especially if we consider the basal angiosperm taxa and monocots. This proposal aims to investigate more in depth these phenomena, using as main model species rice (Oryza sativa), and subsequently to do comparative studies in other evolutionary significant species. The final goal is to achieve a broader knowledge about the transcriptional machinery ruling carpel development, and its degree of functional conservation among the most relevant angiosperm taxa, by means of innovative techniques. The proposal will also allow us to address new evidence about the molecular pathways acting downstream this transcriptional network. The proposal will have a significant impact in basic and future applied research, addressing the Horizon 2020 objective to invest in future jobs and strengthen EU position in research, innovation and technology, sustainable development climate change excellent science.;223120,8;223120,8;H2020-MSCA-IF-2014;MSCA-IF-GF;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 196088;661415;G4invivo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Probing intracellular folding and dynamics of telomeric DNA structures with single-molecule FRET;1/01/2016;31/12/2017;;"Telomeres, the ends of linear eukaryotic chromosomes, are one of the most versatile molecular machines of life. They perform a vital role in several fundamental processes in biology, as maintenance of genome integrity and the regulation of cell growth. Human telomeric DNA consists of thousands of tandem repeats of guanine-rich sequences, terminating the chromosomes. Under physiological conditions, such guanine-rich repeats are capable of adopting four stranded structures, called G-quadruplex DNA. Considerable research has been dedicated to an understanding of functions of telomeres, and during the past decades, much progress has been made towards identifying the underlying processes for G-quadruplex DNA isolated in vitro. However, most of our knowledge of conformation and mechanistic understanding of the balance between the structure and function of telomeric DNA inside cells has remained very limited, largely due to a lack of suitable methods. An opportunity to bridge this gap is single-molecule fluorescence microscopy in combination with Frster resonance energy transfer (FRET), a powerful technique that allows distances, distance distributions, and dynamics of individual biological molecules to be measured even in complex and heterogeneous environments, as cellular milieu.
The goal of this project is to employ such optical single-molecule techniques to perform a comprehensive biophysical analysis of the folding and dynamics of G-quadruplex DNA within live cells. This investigation will provide an idea of how accurately our current understanding of the folding and dynamics of G-quadruplex DNA in vitro describes the situation inside the living cell, and will, among other aspects, be crucial for understanding the biological functions of G-quadruplexes and in particular may stimulate the enhancement of the efficacy of the novel anticancer therapies, which use these structures as an active target for drug development.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 196187;662639;Smartlifts;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Making Lifts Smart for More Connected and Intelligent Services.;1/02/2015;30/04/2015;;"Our product SmartLifts represents an integrated solution synthesizing connectivity and security. It consists of a software-hardware suite that contains a gateway, audio modules, sensors and a management platform that meets six key needs for lifts: Increased security at reduced maintenance cost, guaranteed connectivity based on IP data transfer, maximum integration of hardware already used in lift cabins, large M2M data management capability to send and receive multimedia data, predictive maintenance and inspection applying machine learning based on expert systems, facilitated monitoring of the 74 risks defined by EN 81-80.

The final SmartLifts version to be improved in Phase I) consists of: wireless connection (3G, GPRS) based on IP data transfer, integrated hardware in cabins, data volume, web application for managing emergency phone, predictive maintenance and inspection.

The potential market for SmartLifts is huge considering that the global demand for lift and related services was 86 billion Euros in 2012 and is expected to grow by almost 6 % annually until 2017. There are about 5.2 million lifts in Europe alone. Our two main target groups are lift manufacturers such as OTIS, Schindler, Kone and Orona. These companies also offer lift maintenance services. The second group consists of SMEs that focus only on lift maintenance.

Our overall objective for Phase 2 is to apply breakthrough Smart technology to the historically conservative vertical transport sector with SmartLifts by redesigning the existing prototype and commercializing it. In Phase I, we will create a Feasibility Study and Business Plan.

We will assist in facing European and worldwide challenges improving the security of the vertical transport industry by making lifts smart. The positive societal benefits will be that in the long-run, SmartLifts will allow lifts to be more inclusive as the online lift will allow to send sensor signals for falls or allow constant video surveillance.";71429;50000;H2020-SMEINST-1-2014;SME-1;MERAK SL TELECOMUNICACIONS I SISTEMES;ES;;; 196055;661134;ALIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Associating Literature and the Imaginary with Science: Early Years Education;1/02/2016;31/07/2017;;Our project fits into the narrative movement in scientific literacy but defends a different position with regard to childrens literature in science. We do not see a division between science and literature but rather a fertile convergence between the construction of a storyline and the activity of scientific problematization, a process at the heart of scientific learning. We believe that reading certain fictional narratives offers a conductive environment for engaging young children in scientific questioning. The meaning of the fictional narrative arises from the conflict between the elements of fiction and the elements of reality, between what is within the realms of possibility and what reflects the truth. In contrast, it is through fictional events that natural world phenomena can be questioned. Stories invent a possible world which forces the reader back to knowledge of the real world in order to understand it. Following Bruner, we attribute an epistemic aim to some fictional narratives. This project seeks to understand how pupils aged 3-11 years get involved in science within and outside school based on the reading of fictional picture books with the aim of giving teachers the means to develop integrated teaching systems (science and literature): to what extent does reading fictional storybooks lead children to test their representations of the animal world, and more specifically metamorphosis? We will work with a body of realistic fiction-type childrens storybooks that bring into play the idea of metamorphosis. We will identify the literary sources to which pupils aged between 3-11 years refer spontaneously when they talk about animal transformations. We will analyse the mechanisms which give rise to the childrens questioning about the metamorphosis of animals as well as comprehending the nature and coherence of this questioning with regard to the stories themselves.;146591,1;146591,1;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 196154;661823;DEW;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Detachment of water: Light triggered water droplet release from biomimetic honeycomb-structured polymer surfaces;1/03/2016;31/08/2017;;"Inspired by the Stenoccara beetle, the long term vision for this project is the development of biomimetic smart polymer surfaces which can capture water from humid night air and release it upon exposure to the morning sun through a light triggered mechanism. In moving towards this goal, this project will synthesise new honeycomb structured porous films from light sensitive block copolymers. Their unique hierarchical structure on both the micro- and nano-scales will be exploited for the adhesion of water droplets to the surface, and the light sensitive entities will allow switching of the surface properties to trigger droplet detachment.
The project will expand the field of light-responsive surfaces. Firstly, light-switchable honeycomb structured porous films are yet to be reported. Secondly, unique nanopillar morphology will be introduced by the degradation of a sacrificial polymer to increase roughness and promote hydrophobic droplet adhesion, which has not been reported for honeycomb films. Thirdly, the light-switchable units will consist of a new class of azobenzenes which can be reversible switched between hydrophobic to hydrophilic using visible rather than UV light, which will open up possible applications where UV switching is precluded.";129807;129807;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR;FR;;; 196062;661175;virus-DNP-NMR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of high-field DNP-enhanced MAS NMR techniques for structure determination of viral capsids;1/09/2015;31/08/2017;;"The atomic-level characterization of large viral particles is one of the greatest challenges of modern structural biology, as well as a fundamental step for the design of effective antiviral treatments. In viruses, the viral genome (double- or single-stranded RNA or DNA) is associated to multiple copies of a capsid protein, forming predominantly icosahedral or helical architectures. These complex superstructures are often studied by X-ray crystallography and electron microscopy (EM). However, only information at low resolution is usually available from EM, and extended and flexible architectures do not provide single crystals amenable to diffraction studies. Over the last years, solid-state NMR (ssNMR) has developed into a powerful structural tool for studying structure and dynamics of solid biological samples at atomic resolution and is now uniquely positioned to complement diffraction-based techniques for the characterization of large functional assemblies.
However, proteins of large size or that are available in limited amounts are still inaccessible to site-specific NMR studies. Exploiting a unique equipment available in the host institution, the project aims to remove the current bottlenecks and develop improved dynamic nuclear polarization (DNP)-enhanced ssNMR methodology to push forward the limits of applicability of this technique to macromolecular assemblies, opening new avenues to ssNMR in structural biology. Innovative experimental approaches will be developed to overcome the resolution barriers that currently limit the application of high-field DNP, and new spectroscopic tools will be introduced to allow the structure determination of biomolecules under DNP conditions. The effectiveness and versatility of the newly developed methods will be tested on two viral nucleocapsids of different architectures, the icosahedral capsid of non-tailed bacteriophage AP205 and the filamentous, helical nucleocapsid of Measles virus.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196044;661066;LYMPHOSIGN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Integrated study of the role of B-cell receptor signaling in the development of Follicular Lymphoma;1/12/2015;28/02/2018;;"'Signaling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth and survival. However, direct evidence for BCR signaling in human lymphoma has only come to light recently. In this proposal, I aim to better understand the role for antigen-dependent vs. antigen-dependent BCR signaling as a pathogenic mechanism in the progression of Follicular lymphoma (FL), a indolent lymphoid malignancy that retain BCR expression during malignant progression. Further investigating the intrinsic role of BCR might lead to the development of new therapeutic approaches based on the inhibition of the BCR pathways. Using an innovative loss-of-function RNA interference genetic screen together with an engineered in vitro system allowing to test FL patients's BCR reactivity and identify putative ligands, we will 1) determine whether BCR signalling in FL relies to 'chronic active' or 'tonic' signals and 2) identify the nature of antigen(s) recognized by FL's BCR that may sustain signalling; each signalling pathway offering different opportunities for therapeutic intervention. For this project, I decided to chose the Louis Staudts group at the National Cancer Institute (NIH) for the outgoing phase since his group has been looking for years how to target B-cell receptor signaling as a treatment strategy. The unique expertise in the state-of the art functional genomic methodologies acquired during my stay at the NCI will be crucial for setting-up new scientific projects, promote extended collaborations and strongly support my re-establishement in Europe to reach an independent position.'";200119,5;200119,5;H2020-MSCA-IF-2014;MSCA-IF-GF;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 196096;661431;RE-DEV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Assessing the transition to renewable energy in Rapidly Developing Countries;6/11/2015;5/11/2017;;CO2 emissions are growing extremely fast in Rapidly Developing Countries, which will account for 99% of the global emissions increase by 2035 (BP 2014). Energy demand is set to increase by 75% by 2035 and (if no change incurs) will largely depend on fossil fuels (IEA 2013). In response to these concerns, Rapidly Developing Countries are currently seeking to tap its vast renewable energy potential (IRENA 2013). This shift to renewable energy provides a unique opportunity to study socio-technical transition to low-carbon technologies. Transitioning to renewable energy requires policy reform, infrastructure investment, citizen mobilization, and smart financing mechanisms. The RE-DEV project will examine the conditions for the take-up of renewable energy in Rapidly Developing Countries and, by doing so, uncover its consequences in terms of global CO2 emissions. Drawing on a comparative study of four selected country-cases (China, India, South Africa, and Morocco), this project will offer an in-depth analysis of: (a) regulatory frameworks and existing financing mechanisms, (b) the limits and potential of multilateral climate cooperation, (c) the state of vertical/horizontal transfer of know-how. The country sample responds to a most-dissimilar-systems research design. To gather evidence, this project will employ the following methods: semi-structured interviews with policy makers, questionnaires and a participatory assessment with public/private stakeholders. As a result of this, the RE-DEV project will build knowledge on how to facilitate a sustained transition to renewable energy in Rapidly Developing Countries. I put a strong emphasis on three aspects: the interdisciplinary character of the project, its intersectoral nature, and the crucial issue of its timing it needs to be carried out now, when domestic energy transitions and the post-Kyoto climate change deal (due at Paris COP 21) are at a crucial point of their development.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Centre for International Information and Documentation in Barcelona;ES;;; 196233;663119;BIOTIMA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Market Opportunity Confirmation for Biomimetic Tissue Matrix Products;1/02/2015;31/07/2015;;"A variety of in vitro human tissue models are used in the fields of testing of cosmetics products, drug discovery and regenerative medicine. Most models made from artificial materials do not properly reflect the native tissue morphology and cell composition, while those made of seeded cells/tissues of specific organs lack versatility and are expensive to use. Ferentis Biomimetic Tissue Matrix (BIOTIMA) project addresses the need for efficient toxicity testing/cell culture tools enabling more physiologically relevant, predictive and functional tissue mimicking models, that should become the EU standard in its effort to reduce expensive and inhumane animal testing.
Ferentis scientists have developed an innovative patent-pending biosynthetic material a bioplastic- that is cell-free, stable, biocompatible and optically clear and has demonstrated clinically to promote regeneration of cells. By employing advanced surface nanoengineering techniques, this biosynthetic hydrogel can be deposited, functionally modified and patterned on different substrates, for a variety of lab tissue experiment applications. The unique advantages of our tissue matrix include unique biomimetic properties, most closely mimicking those of the real tissue, and advanced nano-fabrication methods, allowing a cost efficient, versatile and easy to use solution. The prototypes of our TM cell culture tools have been demonstrated in relevant testing environments and now are being piloted with our early adopter customers, with a primary focus on the cosmetics industry. A thorough feasibility study and an elaboration of a business plan is needed in order to analyze the market, map and confirm commercialization alternatives and prepare the roadmap for scaling-up in preparation for Phase II, market replication.";71429;50000;H2020-SMEINST-1-2014;SME-1;FERENTIS;LT;;; 196200;662771;SPARK;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Smart PArallel Robotic Kinematics;1/02/2015;31/07/2015;;Founded in 1994 in the province of Brescia, Italy, we, ALPHA-PROGETTI offer our customers in the sectors of industrial automation customized industrial machinery design and development as well as services in the field of new product development, business development and commercialization. Thanks to our 20 years experience and on-going development works, we have devised a promising business opportunity in the field of industrial robotics machinery for SMEs that outperforms current limitations. SINNOTECH, is a young technological start-up born in 2008 devoted to the development of automated industrial solutions based on innovative kinematic approaches to solve the problem of the dynamic control of industrial robotic systems, where they hold a number of international patents in the field of Multi- polar Parallel Kinematic (MPK) robotics. Our partnership has led us to SPARK, a new technology to build a full portfolio of cost-effective (25% cost reduction per axis, 30% cost reduction maintenance/processing and production) industrial robotic systems and enhanced productivity (20% productivity increase). Our technology shows improved dynamic behaviour (accurate smooth motion at high G, inertia momentum reduction, reactivity, which translate in excellent metrics, being our goal: accuracy <0,018 mm, repeatability <0,01mm, position velocity up to 6 m/s, and acceleration up to 6G. An important fact is that our solution is specifically designed for SMEs, as we pretend to license our technology in exchange for royalties to SMEs in the automotive, electronics and metal sectors, starting with MPK Fiber-LASE Industrial Cutting Systems, to gradually enhanced our portfolio to other types of torch (plasma, water) and other types of machines (welding, engraving, painting) that share same background technology. With a potential turnover of circa 16M within 3 years, SPARK will allow us to substantially increase our finance figures (current turnover about 2M).;71429;50000;H2020-SMEINST-1-2014;SME-1;ALPHA PROGETTI SRL;IT;SINNOTECH SRL;IT; 196018;660941;SQZOMS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Squeezed Light Enhancement of Optomechanical Systems;15/09/2015;14/09/2017;;"Technological advancements over the last quarter-century have led to moving-mirror interferometric experiments obtaining the most sensitive displacement measurements to date. In such experiments, even if classical noise has been reduced, two quantum-noise sources are still present: quantum shot noise (QSN) and quantum radiation pressure noise (QRPN). The combination of these quantum noise sources results in a limit of displacement sensitivity that one can achieve with a coherent laser beam: the standard quantum limit (SQL). Measuring and surpassing the SQL is of keen interest to the fields of optomechanics and interferometric gravitational-wave detection. Since the mid-1980s, the gravitational-wave detection community has been developing quantum squeezed states technologies in order to surpass the limits of quantum noise and the SQL. This technology development has seen excellent success in high profile scientific results.

This project will result in the sensitivity enhancement of a quantum-noise-driven macroscopic optomechanical cavity using frequency-independent and frequency-dependent squeezed light from a newly built squeezed light source. Outcomes of the project include the observation of measurement back-action at the quantum level in both QRPN and QSN regimes, and the first frequency-dependent-squeezing enhancement measurement over a broad frequency band below the SQL.

This project will bring together technology, techniques and expertise at the forefront of optomechanics and quantum squeezed light research fields, leading to synergistic advancement of both fields. It is expected to produce high impact scientific outcomes in a highly strategic field of expertise, raising the research profile of the fellow and of the host group, and will lead to the opening of scientific career pathways in physics and engineering for the fellow.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196071;661214;CURAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cetacean Use of Representational Acoustic Signals;25/08/2015;24/08/2017;;This project will determine if dolphins possess representational understanding of individual-specific signature whistles (SW). Dolphin SWs are a created and learned social signal and are thought to function similar to human names. We will examine parallels between dolphin use of SW and human use of acoustic labels which will give us an understanding of representational signalling systems outside of human communication. Research from the host organization has demonstrated that dolphins use innovated and learned contours to address specific individuals, and research conducted by the fellowship applicant has shown that dolphins maintain the memory of these contours for over 20 years. The next step for both programs is to determine if SWs are representational (i.e. do the SWs elicit a mental image of the caller in the minds of the receiver). Establishing this would show that SWs do function similarly to human names and that long-term memory for these whistles is tantamount to long-term memory for social partners. Furthermore, demonstrating a representational relationship between a signaller and signal in SWs would provide a true understanding of mental representations elicited by signals in a non-humans animal species, something that is extremely difficult to demonstrate in animal communication. To do this, we will first assess the dolphins ability to identify conspecifics by gustatory recognition of excreta. Then, using the practice of cross-modal playbacks of sound and chemical cues, we will look for response differences between matches and mismatches of individual identity coded through the two modalities.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;;; 196072;661232;MAPP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mosquito Antiviral piRNA Pathway;1/09/2015;31/08/2017;;"Mosquitoes transmit several medically and economically important ARthropod-BOrne (arbo)viruses to mammals (including humans), such as dengue virus and chikungunya virus (CHIKV). Unlike infection in their mammalian host, infection in their arthropod vector is apathogenic and persistent due to the interplay between the virus and the innate immune responses. The main antiviral mechanism in mosquitoes is the sequence specific RNA break down mechanism- RNA interference (RNAi), specifically the 21 nucleotide (nt) long small interfering (si)RNAs are considered to play a key role; however, siRNAs are not likely to be essential for the establishment of persistent viral infection. Recently small RNA molecules derived from different pathway have been reported to have an antiviral role in aedine mosquitoes and derived cell lines: PIWI interacting (pi)RNAs (24-29 nt). Persistent infection ensures that mosquitoes remain infectious and if piRNAs control this process, they could play a key part in regulating subsequent arbovirus transmission to humans. Little is known about the piRNA pathway in mosquitoes and even less about its interaction with arbovirus infections. Most of the work has focused on the identification and analysis of (viral specific) small RNAs (siRNA and piRNAs) in infected mosquitoes, but little on the proteins and the protein-RNA interactions involved in these processes.
The proposed research project will use a multidisciplinary approach that involves molecular virology with CHIKV, quantitative proteomics, RNA sequencing and knock down experiments in Aedes aegypti derived cells and mosquitoes to comprehensively understand for the first time the piRNA pathway, its involvement and importance to regulate arbovirus infections in aedine mosquitoes. The findings will extend our knowledge on the interactions between arboviruses and their mosquito vector and generate information that could be used in novel disease-spread control strategies.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 196129;661617;RISTRAD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Risk Stratification for Sudden Cardiac Death;1/05/2015;30/04/2017;;"Sudden cardiac death (SCD) is a leading cause of total and cardiovascular mortality. Ventricular fibrillation (VF) is the most common arrhythmia causing SCD. In young individuals, SCD occurs primarily in the setting of rare cardiac disorders generally considered as Mendelian diseases. Among these are the primary electrical disorders associating lethal arrhythmias such as VF. These disorders are highly amenable to genetic studies since they manifest clinically with specific features on the electrocardiogram.
As of today, the large gap in our knowledge concerning the determinants of VF at the genetic and molecular level hinders breakthroughs in the development of risk stratification and preventive strategies. As a model of a primary rhythm disorder, Brugada syndrome (BrS may be considered as 'sensitized model' for SCD and be relevant to the broad problem of SCD in the setting of common cardiac pathologies.
The aim of this project is to prpose a translational study, combining genome wide association studies in the largest biobank of patients with cardiac arrhythmia ever collected, genotype-phenotype studies for clinical relevance/use and functional characterization for novel genes uncovered.
The overarching aim of the study is to decipher the genetic model of the BrS by identifying novel genetic factors that modulate risk for SCD. We also believe that the impact of this project, although focused on a rare disease such as Brs, will be much broader in the field of cardiac arrhythmias and more generally for SCD.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 196208;662861;OLDIAS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Online Dialysis Sensor;1/03/2015;31/08/2015;;"End-stage renal disease (ESRD) is the most severe form of chronic kidney disease that is an incurable health failure. ESRD is a widespread health issue in developed countries and the patients have only two options: either receive permanent renal replacement therapy or undergo surgery to receive a kidney transplant. There are approximately 3.1 million patients worldwide suffering from ESRD that need artificial methods to replace regular kidney functions in their organism.
The main objective of the project is to validate the uremic biomarkers in a clinical research setting by developing a diagnostic medical device in the form of a novel on-line dialysis sensor that offers a unique method for the biomarker detection. At the heart of the development is technology developed by Optofluid Technologies (OFT) that is free of the flaws of current dialysis monitoring methods such as estimating only urea based biomarkers and will offer enhanced possibilities for dialysis monitoring and quality assessment. This enables the developed sensor to outperform all the current monitoring methods on the market and fully utilize the possibilities of modern dialysis methods resulting in higher treatment efficiency and ultimately disrupting the dialysis equipment market and replacing previous technologies. The market demand has been proven by attracting business inquiries from the leading dialysis equipment producers. Negotiations with selected partners are underway.
A successful commercialization will help to improve clinical decisions by clinicians leading to better treatment. Besides enhanced treatment quality, the novel OFT's technology will significantly reduce the environmental impact of the treatment, reduce the healthcare costs of ESRD patients and improve the patients' life-quality. In order to guarantee a successful commercialization OFT has a team of experts with previous experience in business development and medical technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;OPTOFLUID TECHNOLOGIES O;EE;;; 196015;660883;APOBEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Enzymatic DNA deamination and the immunity/cancer balance;1/04/2015;31/03/2017;;Genomic instability is a key hallmark of cancer. Chromosome translocations require the formation of pairs of double-strand breaks (DSB) and trans-chromosomal ligation of the broken ends. Members of the AID/APOBEC family of enzymes deaminate cytosine (C) to uracil (U) in the context of a polynucleotide substrate. Excision of the U residue from DNA produces an abasic site, leading to incision of the DNA strand containing the abasic site by the conventional base-excision repair pathway. The introduction of proximal incisions on both DNA strands can generate a DSB intermediate for chromosomal translocation. AID acts on C residues at immunoglobulin loci in activated B cells to trigger antibody gene diversification and is the only member of the AID/APOBEC family that is currently known to act physiologically on endogenous nuclear DNA. Off-target deamination by AID results in nucleotide substitutions and genomic rearrangements in B lymphocyte tumours. APOBEC1 edits mRNA transcripts in the small intestine. Liver-directed misexpression of APOBEC1 is oncogenic in transgenic mice. APOBEC3 enzymes are ubiquitously expressed and act on C residues in the cDNA viral replication intermediates as part of a host restriction pathway. APOBEC3A and APOBEC3B have been shown to be capable of causing genomic damage in mammalian cells. Access to the nucleus by APOBEC family members likely permits DNA deamination activity that introduces mutations and genomic instability during tumourigenesis. I have generated mice that harbour FLAG-tagged forms of AID, APOBEC1, APOBEC3A or APOBEC3B inserted at the ROSA26 locus, preceded by a floxed stop sequence for conditional expression. This system will be used to understand the role of cytosine deamination in tumour progression in tissue- and time-specific contexts in vivo through whole genome sequencing of tumours. The long-term goal is to initiate the development of reagents to regulate APOBEC activity in basic science and clinical oncology.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT;DE;;; 196076;661289;Global eHealth;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Creating an evaluation and research strategy and an evidence base for eHealth systems to improve the quality of data collection and care in low and middle income settings;1/06/2015;31/05/2017;;Healthcare in low and middle income countries (LMICs) is undergoing rapid change and addressing a widening range of diseases. The needs of the disadvantaged, underserved and remote communities are increasingly recognized, and there is an emphasis on disease surveillance, measuring and improving quality of care and reducing preventable adverse events. The timely and accurate collection, analysis and use of health information is essential for all these initiatives, and eHealth systems are increasingly seen as essential. The Fellow has led several multi-national eHealth projects in LMICs for over a decade including electronic medical record systems (EMRs). In 2004 he co-founded and co-leads the OpenMRS open source EMR system now deployed in more than 40 LMICs, and its initial roll out in Rwanda, now in over 300 clinics. He has led or co-led 18 innovative evaluation studies of eHealth and mHealth systems demonstrating impacts on clinical care processes and laboratory data access including the first randomized controlled trial of a lab information system in a LMIC to show clinical benefit. The objectives of this fellowship are to (1) evaluate with an RCT the clinical and health service impacts of an eHealth systems in an LMIC, and to evaluate system performance and costs. (2) improve the quality and use of clinical data from EMR systems for care and research in both the EU and in LMICs, focusing on heart disease and diabetes and (3) create a Global eHealth group at Leeds University to strengthen European and Global capacity in eHealth development, implementation and evaluation. The Fellowship builds on the innovative and internationally recognized work of the Fellow, in collaboration with Professor Jeremy Wyatt a world leading expert on eHealth evaluation at the University of Leeds, UK. It will provide a unique opportunity for the Fellow to re-integrate into Europe, make a major step forward in his skills and leadership in eHealth, and achieve a senior career position.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITY OF LEEDS;UK;;; 196029;661007;ProLeMAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ProLeMAS: PROcessing LEgal language in normative Multi-Agent Systems;1/06/2015;31/05/2017;;"Existing technologies usually represent norms as formal rules involving deontic operators. Such a rule-based representation of norms is not suitable to handle real data. Norms emerge from laws via an interpretation process. The methodology of Normative Multi-agent Systems (NorMas) by prof. Boella and prof. van der Torre has been conceived to overcome these limits. Nevertheless, the current formalization of NorMas features two main limitations.
Firstly, its models are based on deontic logic such as input/output logic. Deontic logic is typically propositional, i.e. its basic components are propositions connected by modal operators. A proposition basically refers to a whole sentence. On the other hand, natural language semantics includes a wide range of fine-grained intra-sentence linguistic phenomena: named entities, scope-sensitive operators, etc. It is then necessary to move beyond the propositional level, i.e. to enhance the expressivity of NorMas fit to formalize the meaning of the phrases constituting the sentences (noun phrases, verbal phrases, named entities, etc.).
Secondly, NorMas has never been implemented and tested on real legal text. Currently, NorMas is only a promising logical theory, but it is time to see how it behaves on real data, in order to make it suitable for commercial applications.
Drawing from my past experience in natural language semantics, parsing, and corpora building, I propose a project for extending NorMas in that sense, leading to ProLeMAS: (Processing Legal language in normative Multi-Agent Systems), a new logic for normative reasoning in multi-agent systems. In particular, the present project aims at (1) filling the gap between the current formalization of NorMas and the richness of natural language semantics (2) Implementing a pipeline from legal text to ProLeMAS formulae, passing through parsing and reasoning.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DU LUXEMBOURG;LU;;; 196172;662458;PReDicT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Predicting Response to Depression Treatment;1/02/2015;31/05/2015;;"Depression is a leading cause of disability and produces a greater decrement in health than other common chronic diseases such as angina, arthritis, asthma and diabetes. In Europe, it is estimated that 7.2% of the disease burden is caused by depression with associated costs of 118 billion. It generally takes months before clinicians are able to identify an effective antidepressant treatment for individual patients and during this period a patients ability to work and function socially is severely impaired by their illness. We will address this problem using the Primary Care Emotional Test Battery (PC-ETB) a medical device that is sensitive to changes in negative emotional bias, an early biomarker for the effectiveness of antidepressant treatment. Identifying early, rather than late in treatment, if an antidepressant is working will significantly reduce the time required for the patient to get better and return to normal life. The PC-ETB has been developed from a more extensive product battery that we provide to the pharmaceutical industry for drug development. In Phase 1 we will: (i) Assess the feasibility of using the PC-ETB in primary care in Europe; (ii) Determine how to set up a multinational medical device clinical investigation in Europe; (iii) Expand a health economic assessment conducted in the UK to include other major European countries and demonstrate the healthcare and societal benefits across Europe; (iv) Develop a commercialisation strategy across the major European countries by conducting a market research assessment of the market size, route to adoption, pricing and reimbursement mechanisms. In Phase 2 of the project we will conduct clinical validation of multi-lingual versions of the PC-ETB in a number of European countries. This innovative project is designed to complete the clinical validation of the PC-ETB and enable its launch as an internet delivered product to improve the management and treatment of depression across the European market.";71429;50000;H2020-SMEINST-1-2014;SME-1;P1vital Limited;UK;;; 196140;661667;LearningDeterminants;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Inter-individual variability in learning: an investigation of its determinants;1/05/2015;30/04/2018;;"The ability to extract regularities from the environment (statistical learning) is an essential feature of the primate brain. While inter-individual differences exist in statistical learning capacity in humans, little is know as to their origins. The present project proposes to investigate the cognitive and neural determinants of these differences, and to ask what their impact might be on the acquisition of a foundational skill for education, i.e. reading.
To this end, we will first assess performance in two statistical learning tasks and various cognitive tests in a large group of adults (N=500). Based on the literature and on preliminary results from the outgoing host lab, we predict a link between learning and attention. We will further test this hypothesis by examining statistical learning in a population with high attentional abilities, namely action video gamers. Second, in an fMRI experiment, we will use state-of-the-art analyses to evaluate the hypothesis of a distinct contribution of the hippocampus and of the fronto-striatal networks to learning across participants. Finally, we will estimate statistical learning ability in pre-readers and longitudinally assess its predictive value on reading skills, as subsequently measured in first grade.
Both the projects core questions and the methods chosen to address them are highly innovative and inter-disciplinary, spanning fields as disparate as cognitive sciences, neuroscience, development and education. The project is expected to have a crucial impact on the applicants career, by broadening her experimental skills and scientific horizons, and giving her a chance to run her own study, a first step towards the objective of obtaining an independent position in research. Finally, by strengthening collaborations between partners in and outside Europe, and by taking a grip on timely questions mainly addressed outside of ERA for now, this project is expected to contribute to European research excellence.";261957,6;261957,6;H2020-MSCA-IF-2014;MSCA-IF-GF;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;;; 196040;661048;UVMWREACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Design, fabrication and optimization of a novel integrated UV-microwave assisted catalytic reactor for the continuous flow treatment of wastewater;1/09/2015;31/08/2017;;"UVMICROCAT uses an innovative catalytic mesh assisted by a combination of UV and microwave technology for fast and effective treatment of large volumes of wastewater for water re-use.

The project proposes an environmentally-friendly, totally innovative method for the treatment of toxic and recalcitrant contaminants in wastewater by enhancing the rate of a novel heterogeneous catalytic treatment process using microwave energy and ultraviolet radiation. The modified PAN catalysts developed at DMU has eliminated the need for iron removal post treatment and has broadened the pH range of application, whilst enabling continuous flow processes favoured by industry. In recent years, several reports have demonstrated the use of microwave and ultraviolet radiation to promote the oxidative degradation of bio-refractory wastes due to their advantages of speeding up the reaction, high-efficiency with no pollution to the environment. Nevertheless the use of microwaves in catalysis and in the water and wastewater industry remains at laboratory scale and therefore requires further in depth research. The major challenges in the water/wastewater industries are centered on the poor penetration depth of microwaves. In the project, we propose to design a UV and microwave assisted reactor which overcomes this scale-up problem. The design of the scalable microwave reactor will not only add new knowledge to the sector but open up new areas of industrial application for microwaves.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DE MONTFORT UNIVERSITY;UK;;; 196218;662975;NEUMARQ;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Neurodegenerative disease biomarkers based on high quality wireless EEG.;1/01/2015;30/06/2015;;"The need: Today, although over 6M people suffer from Parkinson's and related diseases worldwide we have no objective early diagnostic test. By the time patients present the symptoms that lead to diagnosis the disease is already very advanced and the options for treatment extremely limited. This has an enormous impact on cost of care and an even greater impact on patient and carer quality of life. An early diagnostic test will revolutionise treatment in terms of slowing disease evolution and improved outcomes, with fewer years in the advanced phases of the disease requiring expensive full-time care.
Our goal: We aim to commercialise non-invasive, very low-cost preclinical electroencephalograph (EEG) biomarkers for synucleinopathies (Parkinson Disease - PD and Lewy Body Dementia - LBD), which will have real impact on both quality of life and cost of care.";71429;50000;H2020-SMEINST-1-2014;SME-1;STARLAB BARCELONA SL;ES;;; 196081;661327;ECDCOP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolutionary Computation for Dynamic Constrained Optimization Problems;1/12/2015;30/11/2017;;Evolutionary computation (EC), as an efficient tool, has been widely applied to solve different kinds of stationary optimization problems. However, many real-world optimization problems are dynamic constrained optimization problems (DCOPs), where the objective function, constraints, decision variables, and environmental parameters may change over time. At present, very few attempts have been made to investigate this kind of optimization problems in the communities of optimization and EC. This project aims to fill this gap. In this project, we will concentrate on the design, analysis, and applications of EC for DCOPs, including the following five main aspects. Firstly, we will design a set of benchmark dynamic constrained optimization test environments which can resemble real-world scenarios. Secondly, we intend to design standardized performance indicators to evaluate EC methods for DCOPs. Thirdly, based on the standardized dynamic test and evaluation environments, we will design some novel and effective EC methods to solve DCOPs. Fourthly, we will present theoretical analysis of EC with different constraint-handling techniques for DCOPs, with the aim of establishing the theoretical foundation of this area. Finally, applying the developed EC methods to deal with DCOPs in rail networks is also one key aspect of this project. This project has great potentials to fundamentally change the way in which DCOPs are treated, both from a real-world point of view and from the point of view of advancing our theoretical understanding. The research results of this project will be of great interest to academia in many fields and of significant benefit to many industries that involve DCOPs.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DE MONTFORT UNIVERSITY;UK;;; 196003;660933;PARADOXGREATLAKES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Security Paradoxes in the Great Lakes: Between the Military-Capable and the Good-Governed State;1/10/2015;30/09/2017;;This project identifies security-governance paradoxes resulting from the European Unions (EU) security practices in the Great Lakes region. Although this region has been declared of strategic importance for the EU, several practices could undermine both the EUs security and normative foreign policy goals. Firstly, military and security measures, to which the EU has contributed extensively, have militarised the region, creating new sources of violence. Secondly, the aim to support military and security self-regulation could imply that the EU is transferring the attainment of security goals to the target states, thus losing some control and autonomy. Thirdly, though the EU has aimed to balance security and normative goals, scholars have questioned the extent to which a military and security-driven agenda is effective and whether it represents an abandonment of the good-governance agenda. Three questions follow from here: Is the practice of supporting military and security capacity undermining the good governance agenda? What implications does this have for EUs normative commitments? And, how effective is this practice for achieving EUs security goals? The research addresses and connects these debates through two specific innovations. It advances the concept of the military capable state, and it proposes an innovative practice-based methodology to explore the implications of this concept by linking it to patterns of security practices in processes of intervention. Highlighting these paradoxes will offer important insights into the interconnection of security and normative goals in policy and implementation.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT BARCELONA D ESTUDIS INTERNACIONALS, FUNDACIO PRIVADA;ES;;; 196057;661149;ReversePlasticity;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolution of the thermal plasticity of gene expression: a reverse evolution experiment using Drosophila simulans.;1/04/2015;31/03/2017;;Phenotypic plasticity, the ability of a genotype to express distinct phenotypes in different environments, is assumed to facilitate individuals coping with new or rapidly changing environments. In the context of climate change, the phenotypic response to temperature has received particular attention since thermal plasticity is affecting the survival of populations and species distribution. Although temperature is an important variable that affects many traits, including gene expression, the genetic basis of phenotypic plasticity evolution remains poorly explored. This project aims at understanding what determines thermal reaction norms, i.e. how gene expression changes with temperature. Preliminary work in the host laboratory suggests that these reaction norms are modified during adaptation of Drosophila melanogaster populations evolving in a new fluctuating thermal environment. Yet, it is unclear whether these changes are the result of selection on phenotypic plasticity or if they are driven by direct selection on the trait value in the novel environments, as both effects are confounded. To detect adaptive change in phenotypic plasticity, we will use a reverse evolution experiment in which D. simulans populations first evolved in one of two different fluctuating thermal environments (hot and cold) and after one year were shifted to the other environment. We will analyse the gene expression profile of these populations at three successive time points during their evolution over a wide range of temperatures (from 15C to 27C). By changing the environment in the opposite direction, we will be able to distinguish between selection on plasticity and selection on the trait value, since the latter will not revert plasticity towards the initial state. Hence, we will distinguish adaptive and non-adaptive components of thermal plasticity of gene expression, and identify genetic pathways under selection for phenotypic plasticity.;178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;VETERINAERMEDIZINISCHE UNIVERSITAET WIEN;AT;;; 196061;661171;SYMULGAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Synthetic magnetism with ultracold Fermi gases of strontium;1/08/2015;31/07/2017;;"Since the first observation of a gaseous Bose Einstein condensate , ultracold atoms have provided a unique perspective into the quantum world. In a few seconds a piece of hot metal is transformed into an extremely dilute, nanokelvin gas, which is governed by quantum statistics - a new state of matter. Quantum gases are so versatile that with the same apparatus one can, for example, explore superfluidity and ultracold chemical reactions, or even search for changes in fundamental constants . A new frontier of physics, with multidisciplinary appeal, explores topological states of matter, such as the ones predicted to emerge when quantum gases are immersed in a synthetic gauge field.
This fellowship will give me the opportunity to work in establishing ultracold strontium (Sr) as a powerful experimental platform to shed light on outstanding problems of magnetism of quantum matter in periodic potentials. Our work will potentially impact other disciplines such as condensed matter and optics. Our specific research goals during this action are:
1. Demonstration of the paradigmatic Kondo lattice model (KLM) in an ultracold gas.
2. Creation of synthetic gauge fields with an alkaline earth element using an optical flux lattice.
3. Observation of synthetic gauge fields in a 4-dimensional lattice of SU(N)-symmetric strontium.
This proposal is only possible and realistic since the host group of F. Schreck - the first group in the world to make a Sr BEC and the only one in Europe with such expertise - has a fully operational apparatus which produces quantum degenerate gases of strontium. This fellowship stay will be mutually beneficial: the host group will benefit from the researcher's experience with artificial gauge fields, and at the same time the fellow will receive world-class training and benefit from the international collaborations of F. Schreck.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 196000;660793;EVI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;'Feeling European'. The Visual Construction of EU Identity.;1/08/2015;31/07/2017;;"European Visual Identity - Summary

This project uses virtual ethnography and semiotic deconstruction to critically investigate how the formation of a European identity is reliant upon political symbols with which EU citizens can emotionally identify, and suggests directions for reforming the Unions symbolic capital1 to encourage greater citizen affiliation with the EU.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 196193;662690;NEW ARYEL;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Advanced Solution for Smart Telemetry Machine-To-Machine applications;1/02/2015;31/07/2015;;"NEW ARYEL will launch in the market an advanced and cost-effective Machine-To-Machine (M2M) solution in the smart telemetry applications market.

NEW ARYEL is innovative compared to the current state of the art because, unlike any other M2M solution, it integrates several advanced M2M functionalities into the same device with clear economic and technical advantages for clients.

Telemetry is a flourishing market estimated to reach global $103 Billion by 2019 with M2M connections expected to reach 33.2 Million worldwide in 2017.

NEW ARYEL is a smart telemetry device, built by Alosys and based on technology already patented by the company, conforming to international ISO standards and EU regulations. It is adaptable to communicate and connect with many different apparatuses, with the capability of real-time, multichannel transmission and unique technical characteristics such as multiple I/O ports, communication channels and open source software currently not available in the market.

NEW ARYEL will provide clients with economic and environmental benefits saving energy, cutting maintenance and downtime. It has already been tested with Alosys clients such as Telecom Italia and Poste Italiane who are also interested to be early adopters.
Target users will be large industries and public/private organisations which need reduce costs and generate revenue through new services. These needs are still unmet by existing solutions.

Thanks to the SME Instrumet Phase 1 Alosys will conduct a feasibility study to deliver a business plan to support Alosys in successful market introduction of NEW ARYEL.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALOSYS COMMUNICATIONS SRL;IT;;; 196114;661517;DRESSINGTHENEWWORLD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dressing the New World. The Trade and the Culture of Clothing in the New Spanish Colonies (1600-1800);1/09/2015;31/08/2017;;"Dressing the New World. The Trade and the Culture of Clothing in the New Spanish Colonies (1600-1800).

What effect did the successful marketing of European products have on the New World at the beginning of the 18th century? And how should one go about studying the European Fashion and Textiles that transformed the way people dressed in the Spanish colonies?
Dressing the New World research project is framed by a unique document, which describes Mexico in 1700s. This document is a rare reference for the knowledge of Spanish America at the beginning of the 18th century, and a very unique source to understand how and why Europe aimed to disseminate its textiles, commodities and fashionable goods overseas.
The research project seeks to consider Early Modern Fashion in detail through this historical piece and other resources from literature, iconography and material culture, merging into different disciplines: Modern History, Art History and Dress History. Finally the research project aims to integrate the impact of politics and global connections in fashion studies for the early modern period.
Official reports, political correspondence and accounts written by travellers are a rich source of information that allows us to write the history of fabrics and fashions and to study their impact, consumption and distribution in early modern times. Taken together these sources will offer a unique manner in which to envisage and articulate textiles and dress in the mix of cultures of the New World from the Spanish conquest in 1521 up to the 19th century, and map up how the global market connected different parts of the world in early modern time.
Matched with a unique source of iconography (the Casta paintings), the achieved research will produce the first illustrated glossary on Textiles and Garments whose were consumed on a global scale in the preindustrial time.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 196185;662635;RemBAP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Remote Building Analytics platform for Utilities to deliver large-scale efficiency to SMEs and commercial portfolios;1/02/2015;30/04/2015;;"Energy optimization is a challenge driven by high energy costs and the increasingly stringent regulatory framework. The characterization of inefficiencies in buildings typically requires complex and costly on-site audits performed by energy management experts, hindering the adoption of energy efficiency measures by small and medium-sized energy consumers, among them many SMEs. Our current web-based software customers have requested artificial intelligence capabilities in our software platform allowing personalized recommendations to be issued remotely by the system to end users. RemBAP is the answer to this demand. It will significantly simplify and reduce the implementation and maintenance costs of efficiency optimization and constitutes a strategic development for our company, DEXMA.

Energy use optimization has become a priority driven by high energy costs and the increasingly stringent regulatory framework. DEXMA is already helping hundreds of medium-sized end-users worldwide reduce consumption through bill tracking, monitoring of utility meters, data analysis and savings verification with our web based energy management software.

As a response to customer demand, this project aims at integrating advanced analytics to our DEXCell software platform allowing for remote recommendations to be issued, significantly simplifying the process and reducing the implementation costs of energy efficiency management. The proposed innovation will allow DEXMA to reach a much higher number of end users, substantially increasing the companys revenue, creating new jobs and ultimately contributing to large scale energy efficiency. Our main objective for Phase 1 is to evaluate the feasibility of the additional technical developments and to outline the feasibility and strategy for commercialization in different market sectors.";71429;50000;H2020-SMEINST-1-2014;SME-1;DEXMA SENSORS SL;ES;;; 196047;661081;ECOSOUND;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ecosystem mechanisms of noise impact on marine fauna;10/05/2015;9/05/2017;;"Defining a Good Environmental Status for ocean noise within the EU Marine Framework Strategy is challenged by our limited knowledge about noise effects on marine fauna.ECOSOUND proposes that there are two broad types of mechanisms of noise impact on individual animals, both with potential population-level effects: bottom-up, i.e. noise responses that operate at the genetic, cellular or physiological level, which are likely to be conserved across taxa; and top-down, i.e. behavioural reactions driven by the life style of each species, which may result in physiological damage and even death.ECOSOUND will study bottom-up effects exploring if noise may induce morphological changes in several invertebrate taxa, selecting study species known to show phenotypic plasticity when exposed to stressors. Identifying developmental mechanisms of noise-effects is critical to predict potential common physiological paths over a wide range of taxa.Top-down effects will be investigated by comparing the life style of four species of deep-diving whales, and developing models to identify the reasons and potential consequences at the individual and population level of the different vulnerability of these species to noise. ECOSOUND will use the largest existing dataset of multi-sensor acoustic tag recordings of these whales, and apply quantitative ecology methods to develop bioenergetics models linking foraging and diving behaviour, metabolic rate, life history and social structure of the species.The results will inform transfer functions for PCAD models of population consequences of acoustic disturbance.ECOSOUND will strengthen the multidisciplinary research profile of the fellow with the fields of developmental biology and quantitative ecology, while contributing expertise on cetacean biologging studies and a new research line on the impacts of noise on marine invertebrates to USTAN. Results are relevant for the EU Marine Framework Strategy in the emergent field of management of ocean noise.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;;; 196157;661868;TRISORP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Energy saving and reducing carbon emissions by applying decentralized advanced trigeneration (CCHP) technology to supermarkets and other commercial properties;1/02/2015;31/07/2015;;"The German SME Klte-Klima-Sachsen GmbH (KKS) has developed and field-tested in a relevant environment a prototype of a highly cost-efficient ECOiCE ammonia/water-absorption chiller system (AWA) driven by the otherwise not utilised low-exergy coupling product heat from combustion engines of combined heat and power plants (CHP) for the purpose of decentralised trigeneration of electricity, thermal heat and cold. Up to three quarters of electric power, and thus CO2, are saved when compared with chillers of comparable refrigeration capacity operating with the established cold steam compression refrigeration technology. The system, using driving heat below 100C, provides adequately low temperatures of -6C as usable cold for industrial purposes and storage of food. With the ECOiCE AWA the company primarily focuses on market segments with continuously high need of refrigeration like supermarkets, hotels, catering and food processing firms for the provision of cold at competitive prices in line with demand.

The aim of the overall project is the strategic development of a new business area for the innovative technology and plant components in the field of application of absorption refrigeration engineering for industrial purposes within the company KKS. The vision of KKS comprises the international market leadership in the field of trigeneration of electricity, thermal heat and cold through cost-saving AWA, which works in the range of capacity up to 100 kW favourable for decentralized solutions and only requires driving heat at low temperatures. Within 7 years from the beginning of the project the number of jobs at KKS will rise by 20% up to 60 and the turnover for absorption chillers will account for 40 m euro per year.";71429;50000;H2020-SMEINST-1-2014;SME-1;KKS-KALTE-KLIMA-SACHSEN GMBH;DE;;; 196013;660953;Lx Micelles;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Coordination chemistry in doubly stabilized micelles for the tageted delivery of cytostatic drugs in cancer therapy;1/06/2015;31/05/2017;;"The treatment of cancer with chemotherapeutic drugs is very often associated with severe side effects limiting their tolerated dose and leading to insufficient therapeutic effects. The application of such drugs in nanometer-sized micelles may improve their biodistribution, but in vivo studies showed fast drug release in the blood stream. We aim for prolonged drug retention and intracellular release by introducing the stable, yet reversible Lx linker in the core of bioresorbable polymeric micelles. This coordinative platinum linker will have two functions: (1) it will facilitate the stable conjugation between the drug molecule and the polymer molecules constituting the micelle and (2) it will act as a stabilizer between the polymer molecules constituting the micelle. This will result in excellent stability of the drug-loaded micelles in circulation. Due to the enhanced permeability and retention effect the micelles will accumulate in tumor tissue, where they will be destabilized intracellularly and the drugs will be released from the linker in the cytoplasm after competitive glutathione displacement.
The Lx linker presents various advantages over other crosslink methods, such as versatility and ease of crosslinking. No platinum-related toxicity was observed in vivo for the linker in previous research. In addition, the amount of platinum may be considered negligible since powerful drugs will be loaded onto the micelles.
This approach represents a safe and unique hybrid method which has the potential to significantly increase the amount of drug deposited at the target tissue and to reduce side effects at non-target sites. By pursuing this significant step forward in cancer therapy, the fellowship will broaden the Experienced Researchers scientific and non-scientific skills via advanced training as well as transnational and transdisciplinary mobility. Furthermore, it will facilitate a lively transfer of knowledge between the participants due to their complementarity.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196124;661580;NoWork;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The long-term effects of unemployment on older workers: Studying life-course influences in social context;1/05/2016;31/12/2017;;Europes population is currently the oldest in the world, and it is still ageing. This demographic shift is changing societies in an unprecedented way. Researchers and policy-makers fear that we will now only have sustainable pension schemes and a sufficiently numerous, well-qualified workforce if people work until old age. Consequently, many current policies strive to increase workforce participation and delay retirement. But can such policies for older workers be effective? Life-course scholars argue that experiences have time-delayed effects. What people experience during youth and mid-age influences whether they work in old age. Thus, policies for older workers may intervene at too late an age to make a difference. This study investigates time-delayed effects on older workers. It focuses on the effects of unemployment spells, which are said to scar work biographies and permanently hamper careers. This study uses the life-course perspective and thereby joins the newly emerging group of empirical studies that consider entire work biographies to explain workforce participation in old age. Its unique contribution is that it considers the role of social context in the form of families and economic crisis. Family members often coordinate their workforce participation and retirement timing. Economic crises increase unemployment rates, which affects the meaning and experience of being unemployed. This study compares the most different cases of Finland, Germany, Italy, Poland and the United Kingdom. Data stem from life-history interviews in the Survey of Health, Ageing and Retirement in Europe, the English Longitudinal Study of Ageing, and a self-administered Finnish survey. The approach combines sequence, cluster, regression and correlation analyses. Findings refine theories on old age, life-courses, labour markets, welfare states, and economic crises. Policymakers can use the insight gained to refine labour market policies.;149438;149438;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 196056;661145;DYNECAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Microscopic Surface Dynamics of Pt and Pt Alloy Electrocatalysts under operation conditions;1/04/2015;31/03/2017;;By employing the in-situ electrochemical video-rate scanning tunneling microscopy (STM) at well-defined single crystal electrodes, we are going to study the surface dynamics of the atoms on Pt(111), Pt(553), Pt(533), Pt(111)-Cu and Cu/Pt(111) surface alloy in the absence and presence of oxygen gas, with the aim to probe and understand the restructuring of Pt and Pt alloy catalyst of the fuel cell cathodes under the operation conditions. Simultaneously, in-situ electrochemical surface Raman spectroscopy will be used to identify the surface species and their interaction with electrodes, using a version employing shell-isolated nanoparticles that is suitable for single-crystal electrodes. On the basis of the observations of STM and Raman spectroscopy, theoretical calculations based on density functional theory (DFT) and Monte Carlo simulations will be carried out to understand the surface electronic structures and to mimic dynamical migrations of the surface atoms. This should yield deep insight into the essential dynamic properties and the impact on the restructuring of these electrocatalysts under operation conditions.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT LEIDEN;NL;;; 196025;660976;BrainiAnts;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Evolution of the social brain: How social complexity affects individual cognition in ants;1/08/2015;31/07/2018;;"This project aims to answer a significant open question in evolutionary neurobiology: how social complexity shapes the brain structure, its associated metabolic costs, and the behavioural capability of individual members of a society. The Social Brain Hypothesis proposes that the complexity of living in group influences encephalization in vertebrates, but this theory has not been critically tested in invertebrate species. Social insects such as ants have miniaturized brains that nevertheless support highly coordinated collective behaviour and striking individual cognitive abilities. This collective behaviour produces an externalized distributed processing of information that may reduce energetic expenses in individual brains.

We propose to address this question through the study of brain metabolic costs of ant foragers under different conditions of sociality. We will examine the effect of distributed information processing (such as the use of pheromones trails to coordinate group activity) on individual cognitive abilities (such as learning) and the energetic costs of specialized brain compartments that underlie behaviour. Our interdisciplinary methodology will combine techniques applied to the study of collective animal behaviour (individual tracking in collective choice and foraging experiments) and neurobiology (immunohistochemistry and neuroanatomical scaling, cytochrome oxidase staining and learning assays) in sister clades of ants that show strong differences in social complexity and thus the relative roles of individual workers and cooperative groups. This novel and integrated approach will allow us to analyze the evolutionary relationship between social complexity and brain evolution.";246668,4;246668,4;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195985;660689;Re.B.Us;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rewiring Brain Units - bridging the gap of neuronal communication by means of intelligent hybrid systems;16/03/2016;15/03/2018;;People suffering for disorders of the Central Nervous System (CNS) often have to cope with every-day challenges. In spite of our strong commitment to primary prevention, CNS disorders significantly impact on the global burden of disease. Thus, restoring the physiological function of a dysfunctional brain is a primary challenge. As pharmacological treatment is not suitable to restore broken neuronal pathways, research is exploring biological and engineering approaches, but the sole exploitation of either of these strategies is technically limited by inherent pitfalls. Neural transplants benefit of the intrinsic plasticity of real neurons, yet the interaction of the graft with the host nervous tissue is consequently poorly predictable. Silicon-based technology provides highly controllable systems, yet at the cost of limited flexibility. Here, we intend to overcome these limitations by exploiting a novel hybrid approach. We will establish a functional partnership between a biological graft neuronal network and an intelligent controller that fine-tunes the dynamics of the graft by activity-dependent neural control and mediates its integration into the diseased host nervous tissue. We aim at obtaining a biocompatible hybrid device of previously unexpected stability, capable of pursuing a self-healing process of dysfunctional neuronal circuits. The novel biohybrid system conceived in Re.B.Us will be at the core of further development of innovative neuroprostheses endowed with intrinsic adaptive behavior and capable of bi-directional communication with the host CNS, that would restore, by themselves, the function of a diseased brain, with no anatomical or pathophysiological boundaries. By virtue of its unprecedented therapeutic potential, Re.B.Us will undoubtedly impact on EU economy by reducing the financial burden of public health and improving the societal impact of CNS dysfunction.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;IT;;; 196042;661057;CONGO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hybrid Political Orders and Violent Exchanges in the Eastern Congo;1/04/2016;31/03/2018;;Based on anthropological fieldwork in the Eastern Congo, this study investigate hybrid political orders e.g. state and non-state groups, such as militias, police, military, local criminal gangs and local authorities such as village chiefs or warlords whose operations transcend the boundaries of what we normally know as state and nonstate and how such actors exercise power through alternative ways of governance and authority. To do so, I apply the concept of violent exchange (Jensen 2013). This concept is fruitful in explaining how violence opens up a space in which people are forced to engage with armed networks. In this way, it enables an exploration of bottom-up relations and the how authority yields profits through violent interactions. The study has a strong comparative and interdisciplinary approach as it will contribute to critical inquires that questions the western assumption of state power. The study will be part of a wider research project located at the Danish Institute against torture in Copenhagen, Denmark, where a group of senior researchers are carrying out fieldwork and examining violent exchanges in the Global South. In this way, it will contribute to social science and anthropological theory, to develop the concept of violent exchange through fieldwork and bring new empirical data. The results of this study will help to find new methods to monitor violence and to improve human rights work in fragile states.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DIGNITY-DANSK INSTITUT MOD TORTUR FORENING;DK;;; 196099;661441;STTDAA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Synthesis of Truncated Tirandamycin A-D Derivatives as new Antihelminthic Agents;1/06/2015;31/05/2017;;"This project entitled Synthesis of Truncated tirandamycin A-D derivatives as new Antihelminthic Agents (STTDAA) aims at developing novel asparaginyl tRNA synthetase (AsnRS) inhibitors as potential antihelminthic agents, with new mechanisms of action for potential treatment of lymphatic filariasis (LF).
LF is one of the World Health Organizations (WHO) top 10 neglected tropical diseases (NTDs), This incapacitating disease has infected over 200 million people in 73 tropical and subtropical countries, while more than 1.4 billion people remain at the risk of infection. Thus a top priority of the WHO is to search for new antihelminthic drugs that kill adult worms (macrofilaricides), have new mechanisms of action, and exhibit fewer side effects than currently available medications such as albendazole and ivermectin to which parasite resistance has already been confirmed.
To this end, two distinctively different but complimentary synthetic approaches towards tirandamycin A-D (TAMs A-D) derivatives, as AsnRS inhibitors will be developed. This will be followed by intensive structure activity relationship (SAR) studies, which will further promote improvements of the bioactivity and the drug characteristic of the synthesized derivatives. These studies will compose a vital part of a more comprehensive drug development program.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 195988;660711;NeuPheMi;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neurophenomenology of Mental Imagery;22/03/2016;21/03/2018;;"The NeuPheMi project presents a novel approach in the neuroscientific study of mental imagery. Mechanisms of mental imagery are not yet well understood and while traditional approaches investigated their neural correlates based mostly on problem-solving tasks, NeuPheMi proposes to shed the light on the neural correlates of experiencing mental imagery. By taking into account the subjective experience and using electroencephalography and brain stimulation techniques to investigate the dynamic of neuronal activity during mental imagery in an original neurophenomenological approach, NeuPheMi is expected to bring a better understanding of the neuronal basis of mental imagery and extend our comprehension of human consciousness.
Conjointly investigating the subjective experience and cerebral activity during mental imagery is a considerable research challenge, with tremendous benefits to both applied and basic science directly in line with the European research priorities, as underlined in the Horizon2020 Future and Emerging Technologies initiative Knowing, doing and being: cognition beyond problem solving.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF PLYMOUTH;UK;;; 196144;661777;MagicTin;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploring the shell structure of exotic Sn isotopes with an Active Target;1/01/2016;31/12/2017;;"The MagicTin proposal aims at the use of a new generation active target detector (ACTAR) to study the shell evolution in exotic Sn isotopes. The goal of this project is to commission the ACTAR demonstrator, optimizing it for the neutron-rich beams produced at the forthcoming second generation radioactive ion beam facilities.
Worldwide, the availability of exotic ion beams is providing new insight on the evolution of nuclear shells far from beta stability, advancing our understanding of the nuclear force. Measuring transfer reactions, in particular 134Sn(d,p)135Sn, will allow to search for signatures of the existence of a new sub-shell closure at N=90 and to study, in this very neutron-rich region, the nucleon-nucleon interaction in the nuclear medium coupled to the continuum.
Experiments where conventional techniques cannot be employed due to low-beam intensities will become feasible using the ACTAR device. This consists of a time projection chamber where the gas is used both as target material and as reaction products detector. Thanks to the fact that the interaction point lies inside the gas volume, very low detection thresholds can be obtained. Detection efficiency is also remarkably improved and this is essential when dealing with low intensity exotic beams.
The beneficiary institution is deeply involved in the ACTAR development and the supervisor is managing an ERC project that aims at coupling ACTAR with gamma-ray detectors. Through the MagicTin project, the experienced researcher will have the possibility to learn the ACTAR technology, deeply contributing to the setup of the device for the exotic Sn physics case. Moreover, the experienced researcher (ER) will exploit his experience on scintillators to contribute in the development of the gamma-ray detectors. The ER will be also in charge of a commissioning experiment with the 120Sn stable beam: this task will allow him to re-enforce his research independence and maturity.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 196046;661068;INDLINK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Growth and Diversification in the Presence of Industry Linkages;1/04/2015;31/03/2017;;"This project investigates the growth and diversification patterns of countries in the presence of industry linkages in four separate but complementary objectives. In the frst objective, the consequences of the linkages will be captured through the observed pattern of industries throughout countries and an economic micro-foundation will be provided using trade models. In the second objective, the diversification pattern and speed of countries will be related to the country level and product level quality measures. In the third one, temporal aspect of the trade data will be used and the effects of the spillovers will be analyzed using vector autoregressive models. Finally, in the fourth objective, effects of one specific type of spillover, namely the Input-Output linkages, will be explored both theoretically and empirically.
The Experienced Researcher intends to build a successful academic career and impacting the decisions of policymakers within Turkey and Europe. This fellowship will enable Dr. Yildirim to embark on such a journey in a suitable environment provided by Ko University. The fellowship will complement Dr. Yildirims interdisciplinary background and he will also have the opportunity to establish himself in the field of economics.";157845,6;157845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KOC UNIVERSITY;TR;;; 196032;661015;OceanIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ocean Interaction with Antarctic Ice Shelves;1/05/2016;30/04/2018;;The primary goal OceanIS is to constrain the contribution of changes in Southern Ocean circulation to the recent acceleration in Antarctic Ice Sheet mass loss. Improving our knowledge of ice shelfocean interactions is a critical step toward reducing uncertainty in future sea level rise projections. Ice shelves are coastal areas of floating ice that extend from an ice sheet out over the ocean, and their destabilization can trigger rapid ice discharge. It is now evident that oceandriven basal melt is the major cause of ice loss from Antarcticas fringing ice shelves. However much of the fundamental dynamics of how the ocean delivers heat to the ice shelves remains unresolved. Progress in this area requires bringing together the fields of ice shelfocean interactions and largescale Southern Ocean oceanography. The Southern Ocean overturning entails the upwelling of Circumpolar Deep Water (CDW) offshore Antarctica. The Antarctic Circumpolar Current has shifted poleward, the impact of which, e.g. over the upwelling of CDW, remains unknown. Since CDW is linked to the highest ice shelf thinning rates yet observed, the variability of the CDW properties and its interaction with the ice shelves is the focus of this proposal. To do this, OceanIS integrates, for the first time, several unique data sets, which extend from the deep ocean to the subice shelf environment. These include data from the Argo network, instrumented seals, and measurements from the only decadalscale record of ocean properties beneath an Antarctic ice shelf, the Amery ice shelf. OceanIS will help to test which of the suite of current climate models shows iceocean interaction processes and CDW variability that are most in line with reality. Given that the forcings driving Southern Ocean changes are expected to continue in the future, results of OceanIS will be a major step toward reducing the uncertainty that surrounds the future stability of the Antarctic Ice Sheet and sea level rise projections.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SOUTHAMPTON;UK;;; 196109;661501;CEDMMC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Consumer Experience Design Model for Mass Customisation;21/09/2015;20/09/2017;;"This proposal is an opportunity for a promising academic at the beginning of her career with expertise in user interfaces and user experience to work and train with two internationally recognised centres with expertise in geometric modelling and mass customisation. This collaboration will significantly boost her career progress and will allow her to develop into a mature and professional European Researcher as a leading figure in the subject of mass customisation user experience. It will also establish a long lasting connection between the two Hosts and the Hosts and the Applicant.
In mass customisation (MC) creating a satisfying and engaging experience for the consumer is significant, which has been considered as one of the success factors for MC, especially in terms of increasing consumer loyalty. Nevertheless, a number of effort has been made mainly focusing on the technical and business implementation of MC, very little research considers the consumer interaction and consumer experience in MC environment, even though some of them focused on the menu choice design rather than creating an overall experience of interaction, and some of them investigate consumer experience from the manufactures perspective rather than the consumers perspective. Given these considerations, this research is designed to identify a framework in terms of positive and negative influences of online MC design on consumer experience; identify strategies for initial functional model for MC design based on previous framework; validate the strategies to further develop the model, and use the model to inform the best practice guidelines to provide the design reference and standards for MC.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BOURNEMOUTH UNIVERSITY;UK;;; 196178;662498;eTAG;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Thermoacoustic- based residential mCHP system;1/03/2015;31/08/2015;;"The eTAG (embedded ThermoAcoustic Generator) includes a novel electricity- generating thermoacoustic engine, embedded inside an existing residential boiler, to form a renewable and economic micro Combined Heat and Power (mCHP) system, without any hot moving parts. The proposed synergetic approach results with a sustainable system, taking full advantage of alternative fuels value to produce regulated electrical power as well as domestic heating, at overall energy efficiency above 90%.
To enable a cost effective application, the embedded electricity generating unit must be highly reliable and maintenance free, thus a thermoacoustically based solution is expected to be the ideal solution.
Qnergy has recently demonstrated 1 kW solar thermoacoustic application. However, the optimal configuration and combined system spec must be refined for best market acceptance, according to consumers needs and budget limitations. In common situations, a typical user will experience an ROI of less than two years; though specific government policies may lead to different optimal power capacities, as net metering allows using an oversized alternator and feedback the grid in excessive electricity.
Thus our planned feasibility assessment will include a thorough business plan, focusing on market needs, time to market, and identifying the main customers and competitors; resulting in a measurable product specification and detailed risk management plan.
Additionally, the key factors affecting overall system performance will be identified according to the thermo-acoustic-electrical simulation and the detailed design model. Moreover, a full freedom to operate IP survey will be performed, while the product cost, manufacturing technologies and its limitations will be covered.
During phase 1 broad market understanding would be sought, allowing to better select the content and schedule of the following phase 2, focusing mostly on particular techniques for lowering the $/W value of the full system.";71429;50000;H2020-SMEINST-1-2014;SME-1;QNERGY ACS LTD;IL;;; 195999;660783;TERA-NANO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Beam steering, frequency reconfigurable terahertz photomixer array using nano-actuators;1/04/2015;31/03/2017;;"The research on terahertz technology has become one of the emerging fields due to the unique properties that it offers, presenting enabling alternatives in imaging, spectroscopy, and communication applications. Increasing research activities in the field also brings the need for high performance components that operate in the terahertz regime, the most important of which are the high performance sources and detectors. Photomixing is one of the most commonly used methods for terahertz generation and detection, which employs an ultrafast semiconductor substrate integrated with an antenna. The state-of-the-art photomixer antennas have either a low radiation resistance in a wide band or a high radiation resistance in a narrow band, both of which introduce a significant reduction in the amount of terahertz power generated or detected. Possible antenna reconfigurability options to overcome these issues have not been investigated so far due to the lack of high performance switching elements in the terahertz band, which could boost the antenna, and hence, photomixer performance significantly. Moreover, electronically controlled beam steering possibilities, which could enhance the system performance radically in terahertz imaging and communication applications, have not been studied to date, which also requires high performance switching elements.
In this project, we aim to develop, for the first time, beam steerable and frequency reconfigurable photomixer antenna array for terahertz generation and detection. Beam steering and frequency reconfiguration will be achieved by means of nano-actuators, which is expected to provide high performance switching at terahertz frequencies. The nano-actuators that we target to develop will be the smallest ones reported up to date, which is mandatory to integrate them into the very small antenna dimensions. The proposed project will be a high level of interdisciplinary research between optics, electronics, and mechanical engineering.";157845,6;157845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;ANKARA YILDIRIM BEYAZIT UNIVERSITESI;TR;;; 196170;662454;Spoilage Down;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Increasing the efficiency of European food supply chain through in-memory supply chain planning;1/02/2015;31/05/2015;;"RELEX has built an innovative supply chain management solution for the demand forecasting and inventory optimisation of retailers and wholesalers. Unlike traditional supply chain management solutions, RELEXs is built on a unique columnar in-memory database and uses optimisation algorithms based on the supply chain research of the company founder. As a result, it is less costly, more flexible and much faster than traditional disc-based solutions. RELEXs main future challenge is to develop the solutions functionalities and scalability to better serve food retail and wholesale sectors, where the business benefits are the greatest, and develop a marketing and deployment process and organisation to support rapid internationalisation. The project enhances RELEXs capabilities to address the whole European food supply chain market. When launched, the solution will enable food retailers and wholesalers throughout the EU to decrease spoilage, increase profits and improve customer service. In the EU scope, spoilage reduction would amount to 1130 million tonnes p.a. This would reduce CO2 emissions by 2260 million tonnes. The same challenges in food supply chains not limited to the EU, hence the innovation has potential for a global reach.
In the feasibility assessment we will 1) prioritize product development requirements for maximum market impact by listing development options and rating them with (prospective) customers, 2) generate a market entry plan based on macro level data on numbers and company sizes of food retailers and wholesalers in EU countries, 3) select the best way for scaling up the processing capacity by evaluating product development needs for using clustered servers or public cloud server capacity and comparing cost structures of these options, and 4) generate a feasibility study with a business plan that takes into account corporate finance questions, based on which the larger main project can be realized e.g. by the SME instrument Phase 2 funding.";71429;50000;H2020-SMEINST-1-2014;SME-1;RETAIL LOGISTICS EXCELLENCE - RELEX OY;FI;;; 196010;660894;Gregory;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gregory Nazianzen's methodeology of the theological arguing;1/07/2015;30/06/2017;;"The objectives of the research project are to show how a strong focus on an early Christian authors use of classical rhetoric and philosophy (fx. Plato and Aristotle) can deepen our understanding of style and content of ancient Christian texts. This will be exemplified by detailed rhetorical and philological analyses of Gregory Naziansens five theological orations. Modern literary theories of reception will be employed to illuminate how Gregory used classical rhetoric and philosophy. The research project will thus revitalize traditional methods of classical philology and combine them with modern literary theories. Further I will study the composition of the cycle of the five theological orations arguing that they are written as a coherent whole. Each oration will also be studied separately clarifying which rhetorical and philosophical methods and techniques the author has used, which connections with classical pagan and early Christian (Alexandrian school) traditions they show, and which kind of theological arguing (positive and negative theology) they are characterized by. The proposed research will at the same time serve as a model for how philological and rhetorical analyses and theories of reception can be used as a tool for analyzing other ancient Christian texts.
The aim of the action is further to train the researchers skills in using theories and methods necessary for carrying out the research project. In addition to the training in skills directly connected to the research project the researcher will also be trained in general and transferrable skills such as research administration, academic writing, writing of research applications, use of electronic resources in humanistic research, methods to disseminate research results (academic publishing, use of electronic media, teaching etc.).";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 196203;662792;Suninbox;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Portable SolUtioN for dIstributed geNeration in a BOX;1/02/2015;31/05/2015;;"Our project arises from a joint business venture between Solarbox Solar Solutions (Solarbox) and Generaciones Fotovoltaicas de la Mancha (GFM) to develop a portable solution (Suninbox) for the off-grid generation market. The joint venture started in 2007 for the design of a solar tracker (Patent ES 2322527B2) to increase the collection efficiency of solar systems by more than 30% whilst making it easy to transport to cover the lack of solutions in the market with good price/characteristics rate.
Suninbox consists of a portable Solar PV energy solution that integrates in a certified container all the components necessary to generate electricity autonomously. This will allow both Solarbox and GFM to gradually reach industrial scale with increasingly lower costs (objective price of 4.25 /W per 12kWp module), increasing penetration in the international market.
Our end users belong to specific markets where there is a need of affordable and portable off-grid energy sources (not connected to the main or national electrical grid):
-RURAL AREAS: they represent 90% of all territory in the EU 27 and 56% of the population. They generate 43% of all economic value and support 55% of all employment. In these areas, there are 12,000 farms of which 69% are small remote farms of less than 5 Ha of agricultural land.
-TRANSCEIVER STATIONS FOR MOBILE COMMUNICATIONS NETWORKS: the off-grid energy source demand in this sector is steadily increasing with a forecast revenue growing from $1.6 billion in 2012 to more than $10.5 billion in 2020. There are approximately 5 million radio base station sites in the global telecommunication network, 900,000 located in areas where central electricity grid connections are unavailable.
-RURAL ELECTRIFICATION IN DEVELOPING COUNTRIES: universal access by 2030 will require 399 TWh for mini-grids and 171 for off-grid. The global market potential is expected to be in the order of more than 250,000 million .";71429;50000;H2020-SMEINST-1-2014;SME-1;SOLARBOX SOLAR SOLUTIONS SL;ES;GENERACIONES FOTOVOLTAICAS DE LA MANCHA SL;ES; 196066;661187;PROVIST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;PROTEASES VISUALIZATION DURING TUMOR PROGRESSION;1/01/2016;31/12/2018;;Cancer is one of the most devastating diseases leading to millions of deaths per year, and cancer research is a major topic in many laboratories in academia and industry. The main goal in this proposal is to understand the biology of cancer progression that will lead to the discovery of new, more tailored and personalized anticancer therapies. One of the largest group of enzymes that greatly contribute in cancer progression are proteases. In this project I will leverage the production of highly selective chemical probes to investigate the contribution of medically important proteases in tumor progression in PDX (Patient-Derived Xenograft) mice models using a new analytical technique - mass cytometry. This goal will be achieved via a four-step approach employing techniques from organic chemistry, analytical chemistry, biochemistry and biology making this project multidisciplinary. Proteases that have been chosen for this purpose are caspases, legumain and cathepsins B, L and S for which I will synthesize very specific, small molecule radiolabeled inhibitors suitable for mass cytometry approach. These probes will be first evaluated on recombinant enzymes and simple cell systems and then they will be applied to PDX mice studies. PDX models offer an excellent possibility to study human cancer biology in system most closely related to in vivo pathology. So far there are no reports in the literature regarding the use of mass cytometry in studies of PDX mice models, which makes this project very unique and innovative. This PROVIST project will be performed in Sanford Burnham Medical Research Institute, USA (24-months outgoing phase, prof. Guy Salvesen Lab) and at Wroclaw University of Technology, Poland (12-months return phase, dr. Marcin Drag Lab). The research and training profile of these units fits all the objectives that are included into PROVIST project (scientific research and personal career development).;227361,6;227361,6;H2020-MSCA-IF-2014;MSCA-IF-GF;POLITECHNIKA WROCLAWSKA;PL;;; 196041;661051;RLOOP-AS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Interconnection between R-loops and co-transcriptional alternative splicing;1/07/2015;30/06/2017;;"R-loops are long RNA/DNA hybrids naturally formed behind RNA polymerase II (Pol II) during transcription, but their persistence is a threat for genome integrity through the creation of DNA damage, leading to cancer development. However, several recent studies reported a new and exciting role for R-loops in gene expression regulation by influencing transcription termination and chromatin modification.
As mutations in several RNA processing factors have been shown to stabilize R-loop formation, we propose here to investigate the link between R-loops and co-transcriptional alternative splicing (AS) and to decipher the underlying mechanisms, a hypothesis supported by our preliminary results identifying more than 3000 splice junctions affected by decreased R-loops upon overexpression of RNase H1. The use of a specific antibody to RNA/DNA hybrids and stabilization/removal of R-loops coupled to high-throughput analysis of splicing (RNA-seq), R-loop profiling (DRIP-seq) and Pol II positioning and measurements (PRO-seq) will allow us to investigate genome-wide regulation of AS by R-loop formation. We will use particular AS events as models to elucidate the molecular mechanisms interconnecting R-loops and AS. Moreover, based on our previous expertise, we plan to study the impact of R-loops on DNA damage-induced AS alteration as a model of physiological regulation of AS by R-loops.
This project will provide new insights on AS regulation through the formation of R-loops and also on cancer progression through R-loop stabilization. Finally, this project will allow me to acquire independent thinking and scientific leadership to reach an independent academic position in France.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;FUNDACIO CENTRE DE REGULACIO GENOMICA;ES;;; 196127;661594;INFANT MICROBIOTA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Elucidating how Bifidobacteria shapes the microbiota in response to infant diet.;1/07/2015;30/06/2017;;"After birth we are colonized by a consortium of bacteria that are critical for health. Bifidobacteria represent pioneer members, and reach high levels within the gut microbiota of breast-fed infants. These bacteria are proposed to be critical for establishing healthy microbiota development and immune defense; however the mechanisms remain unknown. We hypothesize that breast-milk metabolism by Bifidobacteria provides microbial-derived metabolic products key to promoting stable colonisation of other members in the microbiota, suggesting a mechanism as to why formula-fed infants have an altered microbiota and associated increased risk to a variety of diseases. This MCSA seeks to elucidate the function of Bifidobacteria with host diet, by developing a model colon ecosystem colonised with defined infant bacterial isolates to identify key bifidobacterial-derived metabolic byproducts that differ between breast milk and formula metabolism using cutting-edge metabolic tracer experiments and [13C]-Bifidobacteria pseudocatenulatum. Aim 2 will determine the genomic and regulatory elements in B. pseudocatenulatum required for adaption/metabolism of breast-milk or infant formula in the model colon via construction of a genome-wide mutant library generated by high through-put transposon mutagenesis. Metabolites identified in aim 1 will be linked to specific bifidobacterial gene function, based on the identity of essential mutants unable to grow in the presence of breast-milk (aim 2). We will also determine how host diet impacts microbiota composition in the model ecosystem, by monitoring microbial diversity by 16S rRNA analysis. Finally, to promote a healthy microbiota, identified breast-milk metabolites will be used to supplement the formula fed model. This research will provide critical insight into the function and mechanism of how infant diet impacts bifidobacteria colonisation, with the potential to identify key bifidobacterial-metabolites that promote life-long health.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTE OF FOOD RESEARCH;UK;UNIVERSITY OF EAST ANGLIA;UK; 196027;660981;VMHCIRCUITS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deciphering central role of VMH circuits in regulating energy balance;1/04/2015;31/03/2017;;Incidence of obesity has been steadily increasing for the last few decades. A corresponding rise in the obesity associated co-morbidities such as cardiovascular diseases and type-2 diabetes makes it an acute priority to understand the mechanisms underlying body weight regulation. It is well established that distributed brain circuits tightly monitor and regulate energy stores. Of particular interest, electrical and pharmacological manipulations to ventromedial portion of the hypothalamus (VMH), results in dramatic alterations in food intake, adiposity and glucose homeostasis in animal models. Furthermore, human genetic screens have shown that, at least for a subset of morbidly obese patients, genes that are heavily expressed in VMH are altered. Collectively these observations point to a central role for VMH in driving negative energy balance, yet relatively little is known how VMH neurons achieve this. To identify novel mechanisms for controlling energy balance, we propose to determine the following: 1) identify signals that regulate VMH neuronal activity, this includes synaptic input as well as circulating signals, 2) dissect out immediate downstream and upstream synaptic targets of VMH neurons mediating food intake and glucose homeostasis. To achieve this, we will use state of the art neuronal circuit mapping techniques involving virus based retrograde tracers and optogenetics. By combining functional electrophysiology and morphological approaches we will determine brain regions that has connections to and from VMH and evaluate behavioral and physiological significance each of these connections in-vivo. Understanding the basics of the functional VMH-wiring diagram will help determine how these neuronal circuits change under the conditions of metabolic and feeding disorders and will provide basis of targeted approaches for treatment.;145845,6;145845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;ISTANBUL MEDIPOL UNIVERSITESI VAFKI;TR;;; 195973;660616;MALCOD;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Machine Learning for Computational Dynamics;1/09/2015;31/08/2017;;"The proposed research aims to establish groundbreaking new methods for the numerical analysis of dynamical systems by using tools from the field of machine learning. The intersection of the fields of machine learning and computational dynamics is largely unexplored, and this proposal aims at the first systematic development of a unified theory, with a view to applying the ideas to problems in the commercial and energy sectors. Recent results by the applicant in set approximation for control systems demonstrate the power of this approach, the results of which significantly improve on the current state-of-the-art methods for set approximation. This approach is based on a functional analytic framework frequently exploited in modern machine learning methods: the reproducing kernel Hilbert space (RKHS). Algorithms are designed to seek functions in the RKHS that characterise important dynamical properties of the system. This highly interdisciplinary research programme will develop a powerful and unified approach to create new algorithms that can either use input data generated from the evolution equations (if they are available) or measured data obtained directly from applications.

The host institution PIK is a transdisciplinary host institution focused on climate modeling and sustainability. The tools developed during the course of the fellowship will be applied to the problem of basin stability and synchronisation of power grid networks. This proposal also includes two secondment phases to be spent at the non-academic partner organisation Ambrosys GmbH (AMB). There, the applicant will apply the research results to problems in image rendering in movies and turbulent flow across aerofoils, which are commercial applications already studied at AMB. The applicant will benefit from training in climate modeling and complex systems at PIK, and industrial training during the secondment phases.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;POTSDAM INSTITUT FUER KLIMAFOLGENFORSCHUNG;DE;;; 195970;660593;FLORALWOOD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Selecting non-crop flowering plants for enhancing natural enemies of crop pests in agro ecosystems under climate change perspective;15/01/2016;14/01/2018;;Throughout Europe, the expansion of modern, chemical-intensive agriculture is regarded as the principal cause of widespread declines in abundance and diversity beneficial arthropods. Conservation of natural enemies in agricultural landscapes is considered the most ecologically sustainable method for biological control of agricultural pests. An ecological relevant hypothesis is that higher plant diversity, through addition of plant species able to supply accessible food and/or shelters at different seasons of the year, can increase natural enemies' fitness. Based on existing insights in insectplant interactions, specific floral seed mixtures (to be placed in field margins or as ground cover vegetation) can be developed which target specific visiting biocontrol agents. However, the particular mechanisms involved and potential for practical use in farm management remain unclear. In this project I propose to consider the insect community level, including pests and their parasitoids to evaluate the service of pest regulation provided by plant functional and evolutionary diversity at a time when climate change is expected to trigger more frequent or severe insect outbreaks. This will be done by comparing a group of native flowering plants that are already sold by private companies for bees pollination (or other interests) in terms of their capacity to serve as source of sugar (pollen) for aphid parasitoids while resulting unattractive for their aphid hosts. The best resulting plants will be isolately tested under greenhouse to evaluate their efficiency by measuring the resulting parasitism rate by aphid parasitoids under optimal and extremely hot conditions (summer in Valencia, Spain, where this experiment will be performed during the secondment). Training for me will include experimental design, insect physiology, HPLC analysis, wind tunnel management, insect thermal resistance, plant flower and pollen characterization, plant-insect interactions, statistics and others.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;Universit de Rennes 1;FR;;; 196031;661010;WntTraffic;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterising the spatial organisation and regulation of the Wnt receptor complex in stem cells and cancer;1/04/2016;31/03/2018;;"Wnts are a family of secreted glycoproteins that control maintenance and proliferation of stem cell reservoirs during tissue homeostasis and regeneration after injury. Deregulated Wnt signalling due to mutations in important signalling intermediates is strongly linked to disease. The complex molecular mechanisms mediating Wnt-induced cell responses are therefore of wide interest and the underlying protein interactions provide attractive drug targets, particularly in regenerative medicine and cancer treatment.

The earliest events that occur after Wnts bind their receptors at the cell surface, such as receptor endocytosis and recruitment of cytoplasmic effectors, are decisive for downstream gene activation but the underlying mechanisms by which these events process and tune the Wnt signal remain poorly understood. The key objective of this proposal is to resolve critical molecular events that drive initiation of the Wnt cascade in stem and cancer cells. By using a novel tool developed in the Maurice laboratory to detect endogenous Wnt-bound complexes, The Applicant will focus on the following central objectives:

1. To elucidate Wnt receptor localisation in sub-cellular compartments
2. To examine the regulation of Wnt receptor trafficking and turnover in response to Wnt signalling
3. To investigate how cancer cells exploit Wnt receptor trafficking to drive tumour growth

To meet these objectives, The Applicant will be trained to employ an integrated approach combining biochemistry and genome editing in intestinal organoid cultures with advanced imaging including immuno-electron microscopy to develop a unique set of tools to study Wnt receptor trafficking and turnover at the endogenous level. The expected insights will be vital to understand how pathway activation is controlled and for strategies to interfere with Wnt signalling in disease.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAIR MEDISCH CENTRUM UTRECHT;NL;;; 196094;661361;NETPAC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Microbial networks for PAC cycling in polluted soils;16/06/2015;15/06/2018;;Polycyclic Aromatic Hydrocarbons (PAHs) are major soil pollutants causing special concern due to their high recalcitrance and (geno)toxicity. Despite the extensive knowledge gathered on microbial PAH degradation, current biorestoration technologies are still not sufficiently effective to decontaminate contaminated soils. One of the main characteristics that constrain PAH biodegradability in the environment is their low bioavailability for natural microbial communities, and the concomitant limited degradation rates. In addition, at PAH-polluted sites, other toxicologically relevant polycyclic aromatic compounds (PAC), such as oxygenated PAHs (oxy-PAHs) and nitrogen heterocyclic PAHs (N-PAHs), are generally present, their fate and, in the case of oxy-PAHs, formation being normally neglected. As a result, the success of bioremediation and its ecotoxicological assessment are often limited. NETPAC aims to identify the microbial communities and functions relevant for PAC biodegradation, and their adaptations to low bioavailability conditions, to further exploit them in novel and more sustainable approaches for biologically mediated restoration of PAH-impacted soils. Molecular microbial ecology and analytical chemistry methods in combination with stable isotope tracers will allow a systems biology insight into the complex microbial metabolic networks dealing with PAH-biodegradation and bioavailability in situ, by integrating genomics, transcriptomics and metabolomics data. Diagnostic tools will be developed and applied to monitor a lab-scale Green remediation approach based on enhanced natural attenuation, and to identify the natural microbial adaptations to promote the degradation of the expected low bioavailability residue. Understanding these processes will provide us with tools to assess biodegradation occurrence and, as a final outcome, predict the success of bioremediation thus reducing its uncertainties, one of the main drawbacks of this technology.;239191,2;239191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 196188;662651;Visualfy;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Visual Notify - Improving Deaf People's Life;1/03/2015;31/07/2015;;"Visualfy is developing a suite of smartphone Apps, through which it enables people with hearing deficiencies to more seamlessly interact with their environment. Visualfys current minimum viable product (MVP) allows Smartphone events, such as incoming (Video)-Calls, E-mail, and Whatsapp, to be linked to different screen-flash and vibration patterns, to notify a deaf person. Therewith, the MVP solves one of several key problems. Validation of the MVP is currently under way, with early positive responses reflected through currently 5000 customers, with around 200 new customers joining per week.

It is clear that deafness can cause all kind of problems in daily life, like not being able to note alarm sounds, or simply problems with inter human communication. It is less well known that people with pre-lingual deafness (deafness before the acquisition of language) have difficulties to develop a spoken language and even to read and write, as these capabilities are tightly intervened with the formation of language (think of the spoken word forming in your brain while reading). According to the World Health Organization, partial hearing loss affects about 360 million people worldwide, 0.1% being pre-lingual. Considering at the same time a dramatically growing Smartphone penetration, even in poorer societies, establishes a growing market environment.

Initial sales of the MVP are qualitatively validating one key customer problem, and the market seems ripe for disruptive innovation, allowing the introduction of Visualfys Smart Space Concepts to Improve Deaf Peoples Life.";71429;50000;H2020-SMEINST-1-2014;SME-1;FUSIO D'ARTS TECHNOLOGY SL;ES;;; 196085;661408;EAVESTROP;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Eavesdropping on the tropics: assessment of climate change impacts on amphibians through passive acoustic monitoring;1/01/2016;31/12/2018;;Recent climate change is a major threat for conservation of amphibian diversity, the most endangered group of vertebrates. Species distribution models derived from functional traits have been proposed to provide more robust predictions of future climate-induced shifts in environmental suitability than commonly used correlative models. The proposed project aims, for the first time, to examine species vulnerability to climate change through a novel integration of two scientific disciplines, bioacoustics and biogeography, thanks to the use of new tools in acoustic monitoring, signal processing and species distribution modelling. We will first explore how a key and environment-dependent behavioural trait in amphibian anurans (i.e., reproductive calling behaviour) responds across climatic gradients and subsequently expand these findings into larger temporal and spatial scales through mechanistic approach at two levels of organisation, species and community. The MSCA is proposed as a 3-year GF. One of the most cited research groups in ecology (UFG) will host the fellow during the outgoing phase in Brazil, where data collection, first analyses, and training in biogeography will be conducted. The third year of return to the host organisation in France, with a leading group in bioacoustics and signal processing (MNHN), will be devoted to training in acoustic diversity indices, software development, and most transfer and dissemination activities. The MSCA will enable the fellow to be one of the first researchers with expertise in both bioacoustics and biogeography and hence will open up the best career possibilities for him and new collaboration opportunities for the host organisations. As the first using this novel approach, the MSCA is expected to provide advances in these two disciplines as well as to promote new scientific pathways. A series of outreach activities will also contribute to public education and awareness of amphibian decline and climate change threats.;256410;256410;H2020-MSCA-IF-2014;MSCA-IF-GF;MUSEUM NATIONAL D'HISTOIRE NATURELLE;FR;;; 195984;660684;UNRAVELS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;UNderstanding, descRibing And Visualizing Electronic charge in noveL oxide heteroStructures;1/05/2015;30/04/2017;;"'Charge reorganization at the interface between oxides is the key feature of the emerging field of oxide-based electronics ('oxitronics'). Oxides like perovskites, ferrites, manganites (as SrTiO3, BaTiO3, Fe3O4, BiFeO3, CaMnO3) have become the building blocks for complex heterostructures coupling together at nanoscale different electronic and magnetic properties. Heterostructures can be used to create new outstanding electronic devices to go beyond the traditional silicon-based architectures. To control oxides electro-magnetic properties it's mandatory to completely understand the phenomena taking place at the nanoscale, like charge fluctuation and disproportionation, spin symmetry breaking or local chemical coordination experimentally measured with atomic-resolution and directly connected with the changes in the electronic and optical excitations spectra. This project wants to integrate sophisticated ab initio parameter-free simulations, based on Density Functional Theory and including many body effects, through Many Body Perturbation Theory and Time Dependent Density Functional Theory, with measurements in order to understand and to predict the mechanisms in oxides at nanoscale. These transferable and predictive parameter-free approaches will complement and guide the experiment. The direct comparison of calculated spectra with the experiment will permit to identify the electronic origin of the different excitations, their mutual interactions and their coupling driven by other degrees of freedom. The electronic structure of oxides (charge occupation, bandstructure, bandoffsets) across the metal-insulator transition will be calculated through the correct estimation of dielectric screening function; effect of dopants and strain on oxides and interfaces will be analyzed by calculating electronic and optical spectra. Moreover the side-by-side direct comparison between the calculated spectra and measured observables will permit to refine the theory and its ingredients.'";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196017;660814;PLIOTRANS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;PLIOcene TRANSient Climate Modelling: Towards a global consensus between ice volume, temperature and relative sea level for the Late Pliocene;1/07/2015;30/06/2017;;The Antarctic and Greenland ice sheets will be significant contributors to sea-level rise during and beyond this century. An increase in sea level will have considerable impact on ecosystems, the vulnerability of the coast and on society. A better understanding of the responses of the ice sheets to a warming climate is needed to make more rigorous predictions of the impact of regional sea-level variations. The Late Pliocene (3.264 to 3.025 million years before present) was a warm interval in the history of the Earth that can be used to gain a better understanding of the response of the ice sheets to a warming climate. Within PLIOTRANS, I will use a unique ice-sheet - sea-level numerical model and couple this to a high-end numerical climate model for the Late Pliocene to for the first time simulate the time varying climate and ice volume simultaneously. My expertise with ice-sheet and regional sea-level modelling and the vast knowledge on Pliocene climate modelling and data at the participating organisations will definitely create the optimal environment to deliver the objectives of. The fellowship will be highly beneficial to establish myself as an independent researcher. With this innovative modelling framework I will improve the understanding of the sensitivity of the Greenland and Antarctic ice sheets to the warmer then present day climate of the Late Pliocene, to reduce the uncertainties associated with future projections of sea-level change. Geological data for the data-rich last glacial cycle will be integrated into the modelling framework to serve as a constraint on modelled sea-level change over the globe. Accordingly, combining models and data will reduce model uncertainties of sea-level change. The outcome of PLIOTRANS can be used as a benchmark for climate scientists and policy-makers in further reducing uncertainties in future targets for greenhouse gas emissions and the impact of ice-sheet melting within future climate projections.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LEEDS;UK;;; 195995;660757;RAISED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Raman and AFM Integrated Stem Cell Exploration of Differentiation;15/05/2015;14/05/2017;;"The control of stem cell fate via external stimulation (ES) is a vital contribution to the advancement of tissue engineering (TE) for regenerative medicine (RM). In this project we propose a highly sensitive real-time characterisation of stem cells during applied ES in order to fully understand and elucidate cellular mechanisms during differentiation. This will be achieved using three major vectors of research; new conductive polymer (CP) materials for the ES of stem cells, Atomic Force Microscopy (AFM), and Raman microspectroscopy (RMS) live cell phenotyping.
Real-time characterisation using AFM can directly measure single cell elasticity changes from differentiation mechanics such as reorganisation of the cytoskeleton. RMS of living cells can determine the progression of differentiation through changes in biomolecular composition. The combination of these two techniques will provide significantly improved single stem cell characterisation over current techniques, and is fast, non-invasive, and non-destructive.
The differentiation of the stem cells will be driven by external electrical and mechanical stimulation delivered by new CP materials. Control of the ES coupled with the real time characterisation of cells will bring about new understanding of how this ES influences the differentiation of stem cells into the desired phenotype. Improved stem cell differentiation will further refine our knowledge in the TE field, and producing specifically fated cell phenotypes will improve the clinical application of TE for generating new tissues for applications such as cardiac, wound, or bone repair.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 196026;660980;SORT1LIG;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification and characterization of new cytosolic ligands of Sortilin;1/01/2016;31/12/2017;;Protein trafficking is crucial to maintain organelle function and cellular homeostasis, and is regulated by sorting receptors. Sortilin is a membrane receptor that sorts proteins to the predisposed cellular compartments through both secretory and endocytic routes. To accomplish this function Sortilin is endowed with an ectodomain that binds a great variety of cargo proteins, and a cytosolic domain that recruits adaptor proteins to direct the receptor trafficking activities. In the last 15 years more than 20 cargo proteins of Sortilin have been identified leading to the discovery of key Sortilin functions related to lipoprotein metabolism, neurotrophic factor signaling and lysosomal trafficking. However, little is known about the specific mechanisms that regulate Sortilin intracellular trafficking and function, since few cytosolic adaptors, shared with other sorting receptors, have been identified. Based on this, the aim of the present project is to identify and characterize new cytosolic adaptors of Sortilin and shed light on these fundamental aspects. In particular, I will isolate, validate and characterize new adaptors and their binding sites, starting from the outcome of a large-scale analysis of candidate Sortilin adaptors performed by the host research group. To this aim I will use multiple techniques developed for the study of protein-protein interaction and cell biology. The results of this study will provide new knowledge about the Sortilin binding ability, intracellular trafficking and function. Importantly, elucidating the machinery and the molecular/regulatory mechanisms of protein trafficking is crucial to understand cellular physiology and pathology. In addition, since Sortilin is emerging as a major disease gene in cardiovascular, neurological, and neurodegenerative disorders, the results from the present project will provide new knowledge about the etiology of these complex diseases and propose novel therapeutic perspectives for their treatment.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 196051;661106;TITLY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Inhibition of the T-cell receptor signalling pathway for treatment of T-cell lymphoma;1/11/2015;31/10/2017;;"Non-Hodgkin lymphoma (NHL) is a form of cancer emerging from the transformation of a mature B- or T-cell lymphocyte. NHL is the 11th most common cancer in Europe, and the 10th most common cancer worldwide. Functional evidence of the key role of B-cell receptor (BCR) signalling in B-cell malignancies came mainly from works conducted in Dr Louis Staudts lab (National Cancer Institute, Lymphoid Malignancies Branch, Bethesda, USA) where the outgoing phase of the global fellowship would take place. Rapid translation of basic science discovery on the BCR signalling led to the development of a specific inhibitor of a key BCR pathway adaptor named Brutons tyrosine kinase (BTK), which was granted for accelerated approval both in United States and Europe by regulatory medical agencies.
While the potency of BCR pathway inhibitors is currently revolutionizing the management of B-cell malignancies, peripheral (ie mature) T-cell lymphomas (PTCL) still share a dismal prognosis with a 10-year overall survival barely exceeding 15%. Previous work of the experienced researcher provides strong evidence that PTCL similarly rely on T-cell receptor (TCR) signalling pathway for survival. Targeting this pathway could then lead to discovery of potent therapeutic compounds for PTCL treatment.
During the 2 years of the global fellowship, the researcher would first perform a TCR pathway small hairpin RNAs (shRNAs) loss-of-function screen in PTCL cell lines in the group of Dr Louis Staudt where the technic is already available and has been fruitfully applied to B-cell malignancies. Second, the researcher would identify potential pharmacological inhibitors of the previously identified targets both in vitro and in vivo in PTCL cell lines xenograft models. This second phase of the project would take place both among the outgoing team and the return group of Pr Gilles Salles (Centre National de la Recherche Scientifique, Indolent-B-cell Proliferation Branch, Lyon, France).";178603,2;178603,2;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196155;661852;Res2Pel;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Innovative treatment process for biogenic waste and residual materials to manufacture compactedfuels as pellets or briquettes;1/02/2015;31/07/2015;;"In times of declining fossil fuels and increasing problems caused by climate change, it is important to find alternative fuels to ensure an efficient and sustainable energy supply in the future. The use of wood or other energy crops especially the utilization of biomass residues is at the center of research because of the large application potential in the manufacturing of CO2-neutral biomass fuels. So, this proposal relates to the topic SIE 1 2014/2015.
The H.J.X.W. Holding GmbH, a medium-sized Munich based company, developed the innovative treatment process florafuel to convert wet biomass streams into high-grade biomass fuel pellets or briquettes. The positive impact on the fuel quality is the reduction of the water content and of harmful substances such as chlorine and potassium in the biomass fractions. Moreover, mineral particles such as stones, sand, soil and metals are removed during the process which has been realized during the national project RESPEL into a prototype and shown very promising results. Several biomass streams such as grass and foliage have been successfully converted into fuels with a heating value of ca. 18 MJ/kg and all other properties require from the DIN EN 1496-6 in a cost-effective process. The Technology Readiness Level of the developed innovative treatment plant is assigned to level 6. Potential customers are users with organic residues up to 20,000 tons per year, like farmers, composting and biogas plant operators and municipalities.
In project phase 1 a feasibility study will reveal the technical feasibility and the optimal way to reduce the manufacturing costs fostering its market uptake and show how the improved plant can be technically and economically marketable. A business plan will be developed for an optimal commercialization. These two deliverables will serve as a basis for the construction of an improved plant and its commercialization which will be conducted in project phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;H.J.X.W. HOLDING GMBH;DE;;; 196163;662376;Greenrail;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Greenrail: sustainability, safety and saving in the the railroad sleeper of tomorrow;1/02/2015;31/07/2015;;"Greenrail aims to introduce an innovative and sustainable railroad sleeper into the market, able to revolutionize rail transport sector for these features: sleeper composition (internal structure in concrete, coated by an outer shell made up of recycled plastic and rubber from end of life tires usable in any rail lines; sleeper capacity to generate green power during train transit thanks to an integrated piezoelectric system. Compared to traditional concrete sleeper, our product does not share its weaknesses (high ballast deterioration, low resistence to track lateral displacement, high noise and low anti-vibration properties, high manteinance costs, lack of a piezoelectric system that generates electricity). Our users are: railway network operators; energy operators/managers in trafficked railways areas/underground/urban railway network operators. Their needs are: a railroad sleeper that ensures longer lifespan, lower maintenance costs and greater efficiency, is suitable for all railway lines operators, offers additional benefits; a urban solution that helps improve their services, through an energy storage to be used for other purposes. The feasibility study aims to: analyse the European railroad sleepers market and identify opportunities and entry strategies; conduct a comparative analysis with the main competitors; evaluate the environmental, electric and economic assessments of the envisaged solution; search for partners, investors, end-users, clients, universities/research centres and build a database for Phase II and to reach the market. Greenrail product offers something new to Europe, in line with EU challenges and strategies. It represents a project Europe can finance today to achieve its goals - 60% reduction of GHG emissions from transport needed by 2050; majority of medium-distance passengers expected to go by rail by 2050; common approach for the internalisation of noise and local pollution costs on the rail network developped by the EC before 2020.";71429;50000;H2020-SMEINST-1-2014;SME-1;GREENRAIL SRL;IT;;; 196112;661512;HepatoRiSK;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A new tumor suppressor role for RSK2 in hepatocellular carcinoma;1/10/2015;;;"Hepatocellular carcinoma (HCC) ranks third in cancer mortality worldwide. In spite of this, effective treatment options are limited, partly due to a poor understanding of the molecular basis of HCC, which hampers development of targeted therapies. Recently, cancer genome sequencing mapped the landscape of genetic aberrations in HCC and unexpectedly revealed the kinase RSK2 as the most frequently mutated gene in the RAS-RAF-ERK pathway. I hypothesize that RSK2 is a tumor suppressor in HCC by acting as a feed-back inhibitor of the RAS-ERK pathway, since I find that RSK2 mutations are nearly all loss-of-function and that RSK2 loss potently activates ERK kinases in liver cells. The goal of this proposal is to functionally establish RSK2 as a novel and important tumor suppressor in HCC and identify the mechanism(s) whereby RSK2 may feed-back inhibit the RAS-ERK pathway to promote this cancer. This will be achieved through modelling RSK2 loss in liver cells in vitro and in mice. Among other approaches, I will model RSK2-dependent HCC development by mutating genes found co-mutated with RSK2 directly in the adult mouse liver via hydrodynamic tail vein injection of CRISPR/Cas9 reagents, which may cause HCC within months. I will subject cells and mouse models to mechanistic biochemical and phenotypic studies to elucidate the role and mechanism of RSK2 as a tumor suppressor in HCC. Key findings will be validated in HCC patient samples.
The work will be performed in the context of my new role as assistant professor in the host lab, where I will be given formal supervision and management responsibilities. The work combines my postdoc experience in cancer genetics with my hosts beyond-state-of-the-art CRISPR/Cas9 genome editing techniques. Altogether, this fellowship has the potential to uncover new mechanisms for targeted intervention in HCC. Furthermore, it will be an important stepping stone for me towards an independent research career.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195958;660516;ParaplegiaERDros;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Roles of spastic paraplegia proteins in organisation of axonal endoplasmic reticulum;1/01/2016;31/12/2017;;"Axonal endoplasmic reticulum (ER) is a poorly characterised compartment that is mainly tubular, smooth, and forms a network for long distances along axons. Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape. The Fellow will test the model that these proteins help form axonal ER, which is disrupted when these proteins are mutated. The time for this is opportune; the host lab has developed tools to detect impaired axon ER organisation in Drosophila; and new HSP genes, some encoding ER proteins of unknown function, are being identified continuously in human patients. To identify proteins involved in its formation, the Fellow will test ER-localized HSP gene products, both singly and in multiply mutant genotypes, for roles in ER organisation in larval motor axons. She will also test whether similar defects appear in long motor and sensory axons in live adults as they age. Finally she will test the effects of HSP protein loss on the finer structure of ER and its association with mitochondria. Through this work the Fellow will help pioneer characterisation of a poorly understood but important cell compartment: how it is formed and some effects of disrupting it. Along with the broader research and training environment, this will help her to develop a profile for her own work in this area.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 196009;660929;CoopClickCat;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;CoopClickCat;1/04/2015;31/03/2017;;"The CoopClickCat project features Cooperatively operating Click-derived ruthenium Catalysts for the efficient oxidation of organic and inorganic substrates with high rates and turnover numbers. For this purpose, triazolylidene ligands, which are readily available through click-chemistry, will be functionalized with a cooperative donor site for improving the catalytic activity of the bound ruthenium center. The ligand design involves a sterically constraint position of the donor site, thus preventing this group from coordination to the metal center. The availability of a Lewis acid (ruthenium center) and base in a confined arrangement will enable the two sites to act cooperatively, thus providing access to concerted proton and electron transfer processes. This synergistic behavior lowers activation barriers and hence leads to a smoother potential energy surface for reduction and oxidation reactions. This unique arrangement will lead to new oxidative coupling processes and reduction pathways for the activation of abundant starting materials such as alcohols and amines, and eventually also water to reach unprecedented activity in ruthenium-catalyzed water oxidation catalysis. This project efficiently combines expertise of the researcher (Dr. Marta Valencia; hydride chemistry, alcohol oxidation) with core competences of the host lab (Professor Martin Albrecht, University College Dublin; triazolylidene chemistry, water oxidation).";175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;IE;;; 196016;660876;HIGGS-BSM-EFT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Higgs and Beyond the Standard ModelEffective Field Theory, systematic developments.;1/04/2015;31/03/2017;;"The focus of this proposal is to systematically develop the Standard Model effective field theory and to use this formalism to study the Higgs boson.

The need to engage in this effort is clearly well motivated considering current Large Hadron Collider (LHC) results. Developing the general effective field theory framework to include quantum mechanical corrections is essential if future deviations in Higgs properties are to be systematically studied at high precision in a model independent manner. Higgs properties are currently only roughly known, with large errors. The upcoming data set from LHC will be at least five times as large as the data set gathered in the initial run. Further, the LHC will now be operating at twice the collision energy compared to the initial run. Using this rich data set, Higgs properties will be determined with about an order of magnitude improvement in experimental precision.

Resolving more precisely the properties of the Higgs is expected to give evidence for the effects of fundamentally new particles and interactions, involved in stabilizing the Higgs mass against quantum corrections. Utilizing the resources of this grant, calculations of the most important quantum corrections to Higgs production and decay processes in the general effective field theory of the SM will be undertaken. This work builds upon past contributions in this area by the experienced researcher. Phenomenological analyses to refine our knowledge of the Higgs Boson will also be further developed. The final goal that this proposal advances towards is nothing less than to decode, and discover, a more fundamental theory of nature from a pattern of precious clues embedded in future LHC data.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 196173;662461;SENSITIVITYMARKERS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of prognostic biomarkers of chemotherapy response in liquid biopsies;1/01/2015;30/06/2015;;The lack of clinically validated biomarkers to properly select patients for treatment with anti-cancer agents remains a major problem. Patients are not always receiving the most optimal treatment, resulting in poor response rates and high societal costs. By profiling more than hundred drugs on a broad panel of genetically characterized cell lines, researchers from NTRC have identified novel predictive drug response biomarkers for several anti-cancer agents. In the feasibility (Phase 1) study two of these genomic drug sensitivity markers will be validated using whole genome sequencing data of patients treated with the corresponding agents. In addition, a protein kinase that is involved in glucocorticoid resistance in T-cell leukemia will be validated. Proliferation assays will be carried out with blood samples from leukemia patients using proprietary inhibitors that NTRC has developed against this kinase. After successful completion of Phase 1, the project will be extended to other drug sensitivity markers identified by cancer cell line profiling in Phase 2 of the project. In addition, assays to determine the mutant status of cancer genes in circulating DNA and miniaturized proliferation assays with patient blood cells will be developed. In the commercialization phase of the project, novel clinically validated biomarkers and assays for several anti-cancer drugs will be licensed to pharmaceutical and diagnostic companies. The results of the feasibility project will increase the value of NTRCs biomarker discovery platform, resulting in a doubling of turn-over within two years. In addition, novel IP will be generated and licensed to pharmaceutical and diagnostic companies. After six years an ROI of seven times the initial investment is estimated. Overall, the project will result in increased clinical availability of genomic biomarkers, contribute to an overall improvement of cancer therapy, and increased sustainability of health care systems in the EU.;71429;50000;H2020-SMEINST-1-2014;SME-1;NETHERLANDS TRANSLATIONAL RESEARCH CENTER BV;NL;;; 196069;661199;DECAGON;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Doping Colloidal Nanoplatelets: Synthesis, Self-assembly and Spectroscopy;11/01/2016;10/01/2018;;Two dimensional (2D) nanomaterials have attracted rising scrutiny from the research community in the last decade due to their outstanding physical, optical and structural properties. Beyond the well-known example of graphene and other exfoliated bulk materials, a new colloidal route has recently emerged towards such materials and offers a high degree of control on the structure of these nanosheets. Among these, atomically flat, quasi-two dimensional, colloidal semiconducting (CdS, CdSe and CdTe) nanoplatelets (NPLs) have very interesting opto-electronic properties. Our goal is to fully exploit the potential of these NPLs by doping them with transition metal ions (Mn2\, Cu2\ or Ag\). With the help of doping in such small systems, we can tune the absorbance, photoluminescence, carrier density and mobility of these materials and extend the potential of these materials for various applications such as field effect transistor, light emitting devices or photovoltaic solar cells. We will devise new synthetic strategies towards doped semiconducting NPLs and characterize their structural and optical and electronic properties using state of the art techniques. Advanced structural characterization (XRD, TEM, STEM) will be coupled to optical spectroscopy (fluorescence lifetimes, absorption, emission and excitation spectra) both in solution and on single objects. Afterwards, we will assemble these thin doped platelets together to form supraparticles and large-scale assemblies using different soft-matter techniques (depletion interaction, polymer grafting, templating by an interface) in order to tune their optoelectronic properties. A fine control of the assembly process would direct to new fundamental collective effects and easy processing and orientation of doped platelets, which is a prerequisite for their use in applications.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195969;660590;Chenitar;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Impact of chemical form of nickel ions on its molecular targets in some human cells;1/07/2015;30/06/2017;;"An ambitious and multidisciplinary project is proposed to identify on the large scale the molecular targets of different chemical forms of nickel in some human cells. For this aim, a comprehensive and multidisciplinary program is proposed, including toxicity assays, non-denaturing procedures and the development of analytical schemes based on multidimensional electrophoresis and chromatographic separation.
Despite nickel is classified as carcinogenic and nickel allergy is common worldwide, the molecular mechanisms responsible of nickel toxicity are not know. In this sense, to determine the carcinogenicity potential of nickel compounds, the information about the molecular targets of nickel is critical. There is an urgent need to obtain information about the molecular target depending on the chemical form of nickel, as they are not known yet. This project will study a broad range of different chemical forms of nickel in two selected human cells. Cells will be incubated with the different chemical forms in different conditions and the cytotoxicity will be measured. In order to isolate the native nickel complexes, an optimal non-denaturing procedure of will be developed. Information about the uptake of nickel to cells will be obtained and correlated with the citotoxicity results. Lastly, the identification of the molecular targets will be carried out through the development of novel analytical strategies based on the combination of different separation techniques with different detection techniques.
The great novelty of this project is based on the combination of the information obatined about nickel toxicity and nickel uptake with molecular nickel speciation. The information obtained in the project will help to future understanding of molecular mechanisms of nickel related to nickel allergy and nickel carcenogicity. Additionally, the understanding of these molecular mechanisms will also help to the understanding on the mechanisms of other metal allergies.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196079;661322;ECBStrainShift;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification and characterization of the sex pheromone sensitive response gene(s) in the European Corn Borer males;15/10/2015;14/10/2017;;Night-active Lepidoptera are among the most speciose group of animals (~120.000 known species) and they possess a unique sexual communication system: females attract conspecific males by using a species-specific sex pheromone blend. Due to this fine-tuning, the development of novel pheromone systems is an evolutionary mystery: production of a new pheromone blend by females and preference for that blend by males must be established simultaneously, which is difficult to explain when the female blend and the male response are controlled by independently assorting genes. The pheromone strains of the European Corn Borer, Ostrinia nubilalis provide one of the best model system for a better understanding of pheromone (co)-evolution, because in these strains the females produce opposite proportions of E11- and Z11-tetradecenyl acetate, to which only strain-specific males are attracted. The genes responsible for the strain difference in female production are autosomally encoded and identified as fatty-acyl reductase while the gene(s) underlying male response has(have) been found to be sex-linked but have not been identified yet. For years they have been hypothesized to be olfactory receptors (ORs). However, we found with fine-scale mapping that the ORs map away from the Z-linked response locus and we showed two new candidate genes mapping at the male response region on the Z chromosome. The new candidates are involved in neurogenesis in other species and therefore are interesting for all olfaction and neurogenesis studies, including studies on humans. With our multidisciplinary experience, combining genetic engineering, neurophysiology and behaviour, we wish to identify the genetic change of the genes underlying male response in O. nubilalis and functionally characterize their involvement in olfaction. This approach has the potential to a) identify novel genetic mechanisms that underlie the evolution of pheromone communication and b) develop new pest management strategies.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195955;660481;BIPHA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bio-physical processes around marine snow aggregates;1/11/2015;31/10/2017;;"Advancing our understanding of biologically driven sequestration of carbon is crucial given the rapidly increasing atmospheric CO2 concentrations. Diatoms are the most common type of phytoplankton and, as the oceans biological carbon pump, a key component in this process. Diatom aggregates, in particular, comprise a significant fraction of sinking particulate matter drawing down atmospheric carbon to the depths of the ocean. Diatoms produce transparent exopolymeric particles (TEP), a gel-like sticky sugary substance, which plays a significant role in the subsequent coagulation of diatoms into aggregates as their blooms terminate. These sinking aggregates are composed of diatoms, detritus and faecal pellets and are so-called marine snow aggregates.

We will use recent innovations in technology to study the role of TEP content for:

Scavenging of particles
Flow and diffusion within and around diatom aggregates
We will draw upon the specialized expertise of the applicant and the beneficiary to study diatom aggregates in detail using methods which have greatly profited from technological advances:

Particle image velocimetry, and
digital holographic microscopy, in combination with
microsensors, to study mass transfer at a sub-mm scale.

The methods will enable us for the first time to quantify directly any flow inside the aggregates, also called the interstitial fluid flow, and to visualize the aggregates structure and particle composition. Targeting these processes with advanced instrumentation will bring European research on aggregates to the forefront in terms of the technology, but more importantly, our understanding of carbon cycling in the ocean and our position on future climate change impacts.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 196147;661734;PE4PPI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Peer ethnography for the promotion of patient and public involvement: young people and sexual health service development.;8/09/2015;7/09/2017;;"This project will make an innovative contribution to patient and public involvement (PPI) in health through the application of an innovative peer ethnographic method, which offers the potential for new knowledge unobtainable through other qualitative research methods. A group of young people will be trained to conduct ethnographic research amongest their peers on gender relations, sexual initiation and behaviour, perceptions of sexual health services, and priorities for support. The team of peer researchers will be trained and supported in communicating the findings of their research with key stakeholders working in YPs sexual health service provision in one region of the UK. The project will have several lasting impacts: it will provide important insight into the value of peer ethnography as a methodology to be used within PPI, contribute to new knowledge for evidence-based policy-making and service provision in the field of YPs sexual health, and will equip a group of young people (YP) with important research, communication and advocacy skills.

The project will enable the beneficiary to develop critical new skills and experience in the implementation and analysis of PPI in health, while at the same time broadening her interdisciplinary experience and expertise in applied anthropological research methods. She will also gain new skills in training and conducting research with YP. Dr Whites employability will be significantly enhanced through the tailored mentoring provided by her supervisor and other experts at the University of West of England (UWE) and the practical skills she acquires working on the proposed project. By the end of the Fellowship she will be equipped with the expertise and experience necessary to pursue an independent research position, enabling her to progress from the position of Research Fellow to Senior Lecturer, setting her firmly on the path of a professional academic career, towards an Associate Professorship and beyond.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL;UK;;; 196158;661883;EGRET;SIGNED;H2020-EU.1.3.4.;MSCA-COFUND-2014-DP;H2020;European Glaucoma Research Training Program;1/10/2015;30/09/2020;;"Glaucoma is the most common age-related neurodegenerative eye-disease in western society and one of the four major blinding eye diseases (cataract, macular degeneration, glaucoma, and diabetic retinopathy). Glaucoma is characterized by a progressive loss of retinal nerve cells. The early changes are often unnoticed by the patient. If untreated or detected too late, glaucoma will end up in blindness, yielding a profound loss of quality of life for the individual and major costs to society. In Europe, there are approximately 3 million people with glaucoma. They all need chronic medical care and, despite of that, approximately 15% of them will become blind during their lifetime.

Increasing our knowledge on glaucoma and the aging visual system in general has tremendous potential for innovation in glaucoma care and can thus positively impact the future of millions of European citizens : 1) it enables the development of new tools for the early detection of glaucoma; 2) it can inspire the development and implementation of new treatments; 3) contributes to our understanding of the relationships between various neurodegenerative diseases, and 4) contributes to improving healthy aging in general.
Given the vast complexity of the disease, we need researchers that are deeply knowledgeable about glaucoma and intimately familiar with the many different techniques required to study all aspects of glaucoma and the aging visual system: from functional test to anatomy, from gene to ganglion cell, from retina to brain. Generally, knowledge and thus training is fragmented and researchers that have been broadly trained are only scarcely if not at all available at present.
To overcome this, EGRET the European Glaucoma Research Training Program will aim its efforts at teaching young researchers in how to acquire and apply new quantitative knowledge on the aging visual system in health and disease (specifically glaucoma).";2092800;1046400;H2020-MSCA-COFUND-2014;MSCA-COFUND-DP;ACADEMISCH ZIEKENHUIS GRONINGEN;NL;;; 196011;660952;HPpQCD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hard Probes of Hot and Dense QCD Matter;1/09/2015;31/08/2017;;Several kinds of collision experiments such as the heavy ion programs conducted at the Relativistic Heavy Ion Collider (RHIC) and the Large Hadron Collider (LHC) give access to the study of QCD matter under extreme conditions. In particular, the creation of new states of matter as the deconfined quark-gluon plasma or the color glass condensate, where large densities of gluons can be found, present new opportunities to improve our overall understanding of strong interactions. It is proposed to use the several hard probes generated in these kind of setup (jets, heavy quarks, etc.) to study the properties of such states of matter through the implementation of perturbative techniques.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE SANTIAGO DE COMPOSTELA;ES;;; 196001;660795;GABACODEV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role of GABAergic microcircuits with different embryonic origins in the orchestration of early cortical dynamics in the awake mouse pup;1/04/2015;31/03/2017;;"Because of its function in brain wiring and in the generation of early correlated activity patterns, the maturation of GABAergic transmission plays a key role in enabling brain complexity in higher mammals. Indeed, disruption of GABAergic circuitry at several time points can contribute to the generation of developmental disorders such as schizophrenia, autism or epilepsy (Le Maguerise and Moyner, 2013). Both in the murine hippocampus and neocortex, GABAergic interneurons have been shown to participate in the emergence of a precise temporal sequence of distinct correlated neuronal activity patterns during early postnatal development (Crepel et al., 2007; Allene et al., 2008). In particular, GABAergic cells with an extended and divergent axonal connectivity (operational hub neurons) (Bonifazi et al., 2009; Picardo et al., 2011; Cossart, 2013) have been described to be capable of synchronizing single-handedly populations of cells in developing hippocampal slices (Bonifazi et al., 2009). This project builds up on a solid ground of unpublished in vitro data from the host lab indicating that a specific, but diverse functional subpopulation of GABA neurons could also operate as hub cells in the developing neocortex. Experimentally, it will benefit from recent technical developments from the host lab aiming at manipulating and visualizing the activity of single neurons in the awake mouse combining genetic and microscopy tools. Indeed, if operational hub neurons have been described in vitro, it remains unknown how they integrate into functional networks in vivo, and more generally how GABAergic activity shapes early cortical network dynamicsThis proposal aims at translating from the in vitro to the in vivo situation a multidisciplinary approach to investigate the functional contribution of specific microcircuits to the emergence of network dynamics during development.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 196036;661033;CortFit;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Using reaction norms to identify glucocorticoid phenotypes and their relationship to fitness in individuals of a wild vertebrate.;1/04/2015;31/03/2017;;"Environments are currently changing at unprecedented rates, but the evolution of endocrine response mechanisms is still hardly understood. As environmental transducers, hormone levels are plastic, and basic evolutionary questions such as the nature of individually-consistent hormonal traits are still unanswered. The research proposed here embraces hormonal plasticity by using a novel reaction norm approach. Reaction norms are a gold standard in physiological and evolutionary ecology, but have rarely been applied to hormones. Glucocorticoids (GC) mediate environmental responses in many vertebrate traits. Using great tits (Parus major), I will characterize individual GC phenotypes by quantifying GC components and their reaction norms across environmental gradients. These will be assessed repeatedly to test for repeatability, while field studies will explore fitness relationships. I will address four hypotheses: 1) Individuals differ in GC flexibility; 2) Individuals show repeatable GC responses across different contexts and seasons; 3) GCs are related to reproductive success; and 4) GCs modulate reproductive performance. I will quantify GCs at baseline, after capture-restraint and after negative feedback induction in captivity. I will also assess variation in baseline GC along temperature and workload gradients. I will conduct these tests in non-breeding and breeding seasons to calculate repeatability for GC components. I will then adapt these methods to the field, to investigate how GC flexibility correlates with fitness. Finally, I will impose an environmental challenge during the chick-rearing stage by increasing workload to assess GCs and performance. With this novel approach I aim to advance evolutionary endocrinology by identifying individual hormonal characteristics that are repeatable and fitness-relevant. This research represents a topic of high relevance for science and the public and will provide outstanding academic training to an experienced researcher.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 196002;660946;TONEURENDO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;In search for endothelial mechanisms of TPO-induced neuroprotection;1/04/2015;31/03/2017;;"Ageing is recognized as one of the greatest social and economical challenges of the 21century for European societies. With, Vascular Cognitive Impairment (VCI) being one of the leading causes of age-related cognitive impairment and one of the major causes of disability in the elderly. Although, the concept of VCI was introduced in 1993, current treatment is limited to management of vascular risks and symptomatic pharmacotherapy targeting vascular dementia.
The overall objective of this project is to fill the significant gap in early detection, prevention and treatment of VCI. This will be achieved by explaining microvascular mechanism of protective effects of thrombopoietin (TPO) in a novel unique mixed-risk animal model of VCI- specific to hypertension plus carotid-artery hypoperfusion (HH-VCI).
Given increased number of progenitor endothelial cells after TPO treatment, it is hypothesizes that protective effect of TPO is mediated by endothelium. Furthermore, protective effect of TPO is expected to be caused by activation of neoangiogenesis, anti-inflammatory and vasoprotective mechanisms driven by TPO action on endothelial. This hypothesis will be tested in two stages first, in-vitro and second, in-vivo. In-vitro models, will be used to investigate endothelial response to TPO in terms of its modulation of inflammatory response angiogenic potential and vasoprotective mechanisms. In-vivo models of TPOR KO mice and HH-VCI mice will be used to validate and confirm mechanisms identified in in vitro stage of experiments.";146462,4;146462,4;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIWERSYTET JAGIELLONSKI;PL;;; 195980;660648;FOMBIST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fibre-Optic Multi-parametric BIochemical Sensing Technology;12/10/2015;11/10/2017;;"This project aims at developing advanced optical fibre sensing technologies for multi-parametric bio/chemical measurement, urgently demanded from industry and scientific research for quality control and process study. The Fellow, Dr Jiang will be trained on a series of skills related to novel photonic devices and advanced sensing techniques at main host Aston Institute of Photonic Technologies (AIPT) and several other EU hosts. Capitalising upon his original expertise in the study of optical fibre sensing, bio/chemical measurement and liquid diffusion process, the fellowship will make him a unique asset to the EU for tackling multi-parametric bio/chemical sensing by developing new optical fibre sensing technologies capable of measuring several parameters simultaneously. Dr Jiang has proven track record in bio/chemical sensing with interdisciplinary background and his achievement has been outstanding though very young as demonstrated in his CV. The skills and technologies he will grasp will allow him to diversify his capability significantly; including fibre grating design and fabrication (at AIPT), UV and femtosecond laser micro-fabrication, fibre laser, optical fibre interferometry, nano-film coating techniques and modelling techniques for photonic devices, and highly sensitive sensing technologies. In addition, the fellowship will allow him to transfer the knowledge gained through the research to the benefit of his hosts and regional industrial liaisons together with his existing knowledge on bio/chemical detection. Starting from a particular optical fibre device, tilted fibre grating, through modelling, fabrication and optimisation on special fibres the project will explore the rich spectral characteristics of the device to decode a variety of factors for the multi-parametric sensing. Fostered by the fellowship, a leading expert in photonic sensing technologies is expected and will contribute greatly to EU industries and academic communities.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 196139;661659;REINVEST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Financing Affordable Housing Under Localism;1/09/2015;31/08/2017;;"This project explores the urban governance challenge of motivating institutional investment in affordable rental housing for low-middle income households. The high pressure rental markets of US and European urban financial centres, New York, Amsterdam and London, provide sites for the study. The proposers' prior approach to studying hybrid strategies balancing social and commercial aims in housing organizations is extended to institutional investment. This takes us beyond existing studies of financial incentive structures in institutional investment by recognizing the conflicting logics of profit and affordability, and the potential balancing role of localism. Work Package 1 reviews US experience of innovation to attract institutional investment through tax credit incentives and community reinvestment regulation; and uses stakeholder interviews in two European urban centres to identify key local contextual factors and case study sites. Theories of corporate social responsibility, both discretionary and negotiated, are used to develop an evaluation framework for institutionally-funded affordable housing projects. Work Package 2 explores the negotiation and terms of a sample of case study projects using a structured evaluation methodology. Interviews with investors, policymakers and civic stakeholders reveal actor interpretations of governance arrangements that help connect these projects to finance. Investment decisions are related back to the internal logics and structures of investors and to external incentive structures. Governance models are assessed, drawing on concepts of power and legitimacy. Work Package 3 harnesses a partnership with CECODHAS; the leading European social housing umbrella, to convene an expert panel to apply case study findings to European contexts and to achieve impacts beyond the case study settings. This will help to uncover the potential for urban policy to empower civic actors to negotiate finance for local affordable housing projects.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 196097;661433;Topological superfluidity;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Topological superfluidity in ultracold gas of Dysprosium atoms;1/05/2015;30/04/2017;;In the last decade experimental and theoretical studies in condensed matter demonstrated that materials with strong spin-orbit coupling can host a new state of matter for the electron gas - a topological insulator. More recently the concept of topological matter was generalized theoretically to superconducting systems with strong spin-orbit coupling. The topological character manifests itself in the presence of quantum states bound to edges or defects that exhibit exotic physical properties. In topological superconductors, edge states are described as Majorana fermions. These exotic particles - originally predicted in high-energy physics - are non-abelian anyons: their quantum statistics is neither bosonic nor fermionic. Observing Majorana fermions would be the first demonstration of such exotic particles. The field of ultracold atoms seems well suited for the realization of superfluid systems with strong spin-orbit coupling. As shown in recent experimental works, manipulating manipulating atomic internal states with lasers can mimick spin-orbit couplings of strong amplitude. We have constructed at College de france a new experimental setup producing ultracold Dysprosium atomic gases. This atomic species exhibits narrow electronic transitions that should allow one to create such a spin-orbit coupling without substantial heating, which is the main requisite for creating a superfluid state. Combining spin-orbit coupling and strong interactions should lead to the formation of a topological superfluid. We will investigate the structure of quasi-particle excitations of this superfluid, which should exhibit edge modes described as Majorana fermions.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COLLEGE DE FRANCE;FR;;; 195997;660769;SMILE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;3D Silicon Micromachining with Infrared ultrafast LasErs;30/09/2015;29/09/2017;;"The aim of the present proposal is to initiate an interdisciplinary research program to develop 3D micromachining of silicon towards novel silicon photonics and microfluidic applications. We are motivated by the myriad of applications based on 3D micromachining of glass that peaked in the early 2000's, and still continues to impact integrated photonics and microfluidics, among other fields. These successes were achieved using lasers at wavelengths for which glass is transparent (most commonly 1 um, 800 nm and their second harmonics). Most of the important results demonstrated in glass can be carried over to silicon using a long-wavelength laser (beyond 1.1 um, silicon is highly transparent), though it is clear that the physics will be different, not least because glass is amorphous and silicon is crystalline. To this end, we propose an interdisciplinary research effort that includes first developing the necessary laser technology, then building up the physical understanding, and finally pursuing high impact applications. Our approach can be summarized as:

(1) Developing a novel, femtosecond, high-energy laser at 1.5 um,
(2) Developing in-situ diagnostics based on pump-probe imaging of the laser-material interaction,
(3) Exploring the physics of the laser-silicon interaction,
(4) Applying our physical understanding and laser technology as a platform to 3D micromachining of silicon towards novel silicon-photonics and microfluidic applications.";145845,6;145845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Bilkent niversitesi;TR;;; 195954;660480;POSEIDON;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;novel bioreactor Platform for reprOducible, Scalable ExpansIonand cardiac DifferentiatiON of hiPSC in suspension culture;1/10/2015;30/09/2017;;Human induced pluripotent stem cells (hiPSCs) have the potential to revolutionize biomedical sciences, however the standardised mass production, indispensable for their industrial and therapeutic use, is still a major challenge. Impeller stirred-tank bioreactors, currently used for hiPSC bioprocessing, impose detrimental stresses on cultured hiPSCs, resulting in heterogeneity of cells and cell-aggregates, limited bioprocess reproducibility, and low hiPSC expansion efficiency at high costs. The ambitious purpose of the POSEIDON project is the development of a next-generation automated bioreactor platform to significantly improve reproducibility, efficiency and cost-effectiveness of scalable hiPSC expansion. To demonstrate the utility of the method for the production of valuable human cell types, a novel process for hiPSC-cardiomyogenic differentiation will also be established. This pioneering bioreactor will be developed by advanced engineering design methods and will enable controlled hiPSC suspension culture by non-impeller-dependent low-shear hydrodynamic conditions. Purposely designed automated systems will lead to bioprocess standardisation with enhanced reproducibility, efficiency and scalability beyond the state in the art. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, a talented post-doc with a significant track record in bioengineering, and the supervisor, a world leader in stem cell bioprocessing, whose group is embedded in one of Europes leading hubs for regenerative biomedicine. These working conditions will effectively promote the Researchers professional development, providing her with excellent new expertise in stem cell bioprocessing and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will be of tremendous benefit to the European biomedical and pharmaceutical sectors, contributing to the European excellence, competitiveness and quality of life.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDIZINISCHE HOCHSCHULE HANNOVER;DE;;; 196054;661132;DENDRITESONBORDERS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neuronal and dendritic recruitment on neocortical area borders;1/09/2016;31/08/2018;;One of the most striking features of cortex is the elaborate and electrically active dendritic arbors of its neurons. Besides serving as a scaffold for synaptic inputs, dendrites can amplify inputs and act as computational subunits within a neuron. However, the principles governing the relationship between dendritic processing and information flow through cortical networks remain to be elucidated in vivo. These basic principles must be discovered as part of the effort to generate useful theories that relate sub-cellular processes like synaptic integration to computations performed by large populations of neurons. Such theories that link different scales of neural function are an important step for the larger scientific and societal goal to interpret, predict and manipulate neuronal and cortical function in health and disease. We seek to uncover principles describing the relationships between local network activity, dendritic recruitment, and neuronal output in neocortex in vivo in the anatomical context of a visual cortical area border in the mouse brain. Cortical area borders are poorly understood, but offer unique experimental opportunities. Our goal is to exploit the functional asymmetry present at borders to perform strong experiments that ask: Do functionally similar inputs cluster in dendritic arbors? How is the recruitment of individual dendrites related to local network activity? Do different dendritic branches perform separable computational operations in vivo? Going further, we will determine if different streams of information are segregated or integrated at borders. This basic feature of cortex is interesting both computationally and developmentally. The answers will speak to the constraints faced by cortex in managing information flow and creating functional specialization. We hope the innovative approach of leveraging the unique features of an understudied anatomical special case will yield results and a perspective that is original and useful.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195943;660404;RenewablePortfolio;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Market players optimal scheduling under integrating renewables in European electricity markets;1/09/2015;31/08/2017;;"Market player portfolio optimization has become an important area of research in the aftermath of the worldwide deregulation of the power industry that launched competitive electricity markets now embracing all market participant including generation and retail companies, transmission network providers, and market managers.
Development of the innovative methodology for the strategic market behaviour is highly required by all electricity market parts under permanently changing market conditions. For example, generating companies acting on the market compete with each other in serving the consumers' demand and have the opportunity to optimize the use of their production portfolio by pricing and bidding their available production capacity into the market. On the other hand, demand-side participants look for feasible options to avoid the high electricity market prices during peak hours. Production levels and price forecasts are of great importance for system operators, who are responsible for keeping the grid in balance.
Environmental challenges bring new requirements for market parts acting in European electricity markets. The European Strategy 2020 aims to decline global greenhouse gas emissions in most industrialized European countries. Electric energy systems are currently functioning with an increasing portion of the renewable energy productions (e.g. wind, solar based units) whose output depends on stochastic phenomena and contribute to uncertainty in electrical energy systems.
The novel methodology is developed for both supply and demand side market players acting in multiple electricity markets of different time scales to have an opportunity to optimize their portfolio by bidding or hedging against market volatility in order to get the highest possible profit or the lowest cost under stochastic dynamic market environment. The project results in the implementation of the operational tool for energy systems incorporating mainly stochastic renewable production.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DANMARKS TEKNISKE UNIVERSITET;DK;;; 196143;661733;UbiGABA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of ubiquitination in stability and plasticity of the GABAergic synapse;1/05/2015;30/04/2017;;"Proper brain functioning requires a balance between inhibitory and excitatory synaptic activity. This balance can be maintained by regulating the number of neurotransmitter receptors in the postsynaptic membrane. A major inhibitory synaptic receptor is the hetero-pentameric GABAA Receptor (GABAAR), which is stabilised in the synapse by the intracellular scaffolding protein gephyrin. Gephyrin, in turn, is recruited to and stabilised at the synapse by the adhesion protein neuroligin-2 (NL2). Regulation of synaptic strength involves lateral diffusion of GABAARs into and out of synapses, endocytic downregulation followed by either degradation or membrane re-insertion, and altering the size of gephyrin clusters. Altered GABAAR trafficking is implicated in neurological and psychiatric disorders, including epilepsy and excitotoxicity in ischemia. The underlying mechanisms, however, remain poorly understood.
Ubiquitination is a well-known mechanism that regulates protein trafficking and turnover, however its role in stability and plasticity of the GABAergic synapse remains unclear. Preliminary work from the Kittler lab suggests that: 1) the ubiquitin ligase Unk plays a key role in ubiquitination of the GABAAR; 2) gephyrin can be poly-ubiquitinated and that its proteasomal turnover may be regulated by the de-ubiquitinating enzyme OTUD4; 3) NL2 can be mono-ubiquitinated, potentially directing its trafficking, and that the ubiquitin ligase Nedd4 may regulate this process. Thus ubiquitination may play several key roles in regulating the dynamics of receptor, scaffold, and adhesion molecules at the inhibitory synapse.
Using molecular, biochemical, cell biological, and state-of-the-art imaging approaches I aim to study how ubiquitination of GABAARs, NL2 and gephyrin affects GABAAR trafficking, and formation and stability of the inhibitory synapse. This may lead to improved understanding of how ubiquitination regulates neuronal excitability in healthy and pathological conditions.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 196064;661180;SMARTER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A Scalable and Elastic Platform for Near-Realtime Analytics for The Graph of Everything;1/04/2016;31/03/2018;;The SMARTER (A Scalable and Elastic Platform for Near-Realtime Analytics for The Graph of EveryThing) project aims to build a platform that provide the ability to derive actionable information from enormous amount of data generated by the Internet of Everything to leverage data-driven strategies to innovate, compete, and capture value from deep web and real-time information. The project targets innovative research outcomes by addressing Big Dynamic Data Analytic requirements from three relevant aspects: variety and velocity and volume. The project introduces the concept, Graph of Everything (GoT), to deal with the issue of data variety in data analytics for Internet of Things (IoT) data. The Graph of Everything extends Linked Data model (RDF ), that has been widely used for representing deep web data, to connect dynamic data from data streams generated from IoT, e.g. sensor readings, with any knowledgebase to create a single graph as an integrated database serving any analytical queries on a set of nodes/edges of the graph, so called, analytical lens of everything. The dynamic data represented as Linked Data Model, called Linked Stream Data, may contain valuable, but perishable insights which are only valuable if it can be detected to act on them right at the right time. Moreover, to derive such insights, the dynamic data needs to be correlated with various large datasets. Therefore, SMARTER has to deal both the velocity requirements together volume requirements of analysing GoT to make the platform able support near-realtime analytical operations with the elastically scalability.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET BERLIN;DE;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE; 196125;661583;CONSCBRAIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;How consciousness is shaped by neuronal network dynamics;1/05/2015;30/04/2017;;How does the structure of the brain give rise to its function? We will address this longstanding neuroscience question through an interdisciplinary research project, by using computational modelling to study the neuronal dynamics which underlies the specific brain function of consciousness. More precisely we propose to investigate the differences in neuronal dynamics between conscious and unconscious brain states, and how conscious experience is shared across subjects watching a movie. The project capitalizes on using whole brain models that are constrained by anatomical and functional connectivity data from humans and non-human primates. In a first study, we will test whether differentiation of brain activity, as indicated by homogeneity differences of functional connectivity patterns across the modelled brain areas, can serve as a marker of consciousness. In a second study we will construct a whole brain model of experiments in which subjects synchronize their brain activity when watching a natural stimulus such as a movie. Through external stimulation of the model we will determine the set of brain areas that is causally involved in driving this synchronization of conscious experience. The results will give new theoretical insights on how neuronal interactions at an entire brains scale are informative of consciousness and shared conscious experience across subjects.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitat Pompeu Fabra;ES;;; 196021;660958;PIOMES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pbx proteins as pioneer factors promoting signal specificity in mesodermal differentiation;1/05/2015;30/04/2017;;The development of healthy organisms requires the formation of different cellular systems, such as a blood, bone and muscle. All these different cell types arise during embryonic life from specific pools of mesodermal progenitors (MPs). A central question is how distinct MPs are specified and ultimately why different cells respond to signalling pathways in different ways? Critical insights here are directly relevant to conceive strategies for increasing the efficiency of mesodermal differentiation aimed for treating muscular degenerative diseases. To date, in vitro, somitic mesoderm differentiation for regenerative purpose has had limited success. Wnt signalling promotes Embryonic Stem Cell (ESC) differentiation of all the MPs, including skeletal muscles. The activity of specific pioneer transcription factors (TFs) may be the key for converting Wnt signalling pathways into a specific transcriptional program. Pioneer TFs shape the chromatin landscape by opening the chromatin and allowing the recruitment of lineage specific TFs, and thus ultimately control the TF binding dynamics and the acquisition of a specific cell fate. Pbx proteins are pioneer TFs, which are specifically expressed in the primitive streak, the region of the embryo that will produce all mesoderm, and are critical for promoting mesodermal specification. Here, I will establish how Pbx proteins specify MPs and determine the competence of early mesoderm to respond to Wnt signalling. To this end, I will use mouse embryos and murine epiblast stem cells, which are analogous to human ESC (hESCs). My approach combines the strength of an in vitro ESC differentiation method, routinely used at DanStem, with chromatin immunoprecipitation and transcriptional regulation assays, which I have extensively mastered during my postdoctoral training. I expect that my findings will provide novel tools for rational design of strategies to combat genetic and degenerative muscular diseases, such as muscular dystrophies.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KOBENHAVNS UNIVERSITET;DK;;; 196133;661641;PROMETEO;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Reconstructing human oral microbiome composition changes over the last 8000 years with proteomics and metagenomics approaches;1/09/2016;31/08/2018;;"This project aims at reconstructing the evolution of human oral health in Northern Europeans, from the late Mesolithic to modern days, by genomics and proteomics investigation of: human ancient microbiota, human immune response proteins, and food remains preserved in mineralised dental plaque (archaeological dental calculus).
The human microbiota is essential to maintain health, but capable of eliciting disease. Ecological shifts and imbalances (dysbiosis) of the oral microbiota can significantly impact health and cause severe forms of oral pathologies resulting in systemic disease at different body sites. Taxonomic reconstruction of ancient microbiomes and identification of which genes have been gained or lost in their genomes in connection with major lifestyle changes in human history will contribute to the development of more effective preventive and therapeutic approaches for this disease.
The two main research objectives are:
Reconstruction of the evolution of the oral microbiome composition over the last 8000 years, and
Characterisation of the associated human immune responses.
Genomic and proteomics biomolecular evidence will be retrieved from archaeological human dental calculus: a rich, but so far mostly neglected, source of ancient oral biomolecules. Ancient DNA and proteins extracted from archaeological dental calculus will be analysed using state-of-the-art proteomics and metagenomics approaches at the Centre for GeoGenetics, by high-resolution mass spectrometry and high-throughput DNA sequencing-by-synthesis methods. CGG recently led a high-profile study demonstrating the potential of this approach and will further develop this concept using approximately 80 Northern European samples from a wide chronological range. The Researchers skills in computational proteomics will be beneficial to ancient proteomics analysis, and his skills extended to the field of metagenomics.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195940;660400;CovDecRND;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cover-decomposition of multiple coverings under conditions involving randomness;1/09/2015;31/08/2017;;Combinatorial geometry is a very active field where most problems have real life applications. The study of multiple coverings was initiated by Davenport and L. Fejes Toth 50 years ago. In 1986 J. Pach published the first papers about decomposability of multiple coverings. It was discovered recently that besides its theoretical interest, this area has important practical applications. Now there is a great activity in this field with several breakthrough results. The goal of this proposal is to study cover-decomposability, polychromatic colorings and related notions for different geometric and abstract families of sets under various additional conditions, especially random perturbations.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195996;660759;MADDOG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multidisciplinary Adjoint Design Optimisation of Gasturbines;1/09/2015;31/08/2017;;"Adjoint based design optimization techniques are widely recognized as having a large potential to revolutionize the design process of modern gasturbines. By applying such techniques, the optimization of the entire gasturbine system with million degrees of freedom is within reach of the current available computational power. Such simulations include inherently all interactions between the different components avoiding sub-optimal designs.
However, todays reality is far from this prospect. Current adjoint design optimization techniques only consider aerodynamic performance, preventing the optimization of complete systems, as they are by their very nature multidisciplinary. This project will develop an adjoint optimization methodology that goes beyond only aerodynamic considerations and includes other disciplines such as structural mechanics and vibration dynamics concurrently for the first time, such that in the longer term optimization of complete systems will be achievable.
The key to achieving a true multidisciplinary adjoint design optimization is to work with a master CAD geometry that is shared between all the different disciplines. This differs significantly from the current practice in adjoint techniques, which mainly considers parameterisations that are suitable for only aerodynamic optimizations. The involvement of a master CAD geometry requires the differentiation of a CAD system, until now this has not been performed as CAD systems are invariably proprietary and as such not accessible. In addition, the extension of the methodology to multiple disciplines requires for a highly skilled researcher with a background in aerodynamics as well as structural mechanics.
The fellow of this proposal is a research leader at the Von Karman Institute, which has gained significant experience in the area of multidisciplinary design optimization of turbomachinery over the past 9 years and is the developer of a gradient free optimization system which includes a dedicated";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 196110;661502;BinCosmos;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The impact of Massive Binary Stars through Cosmic Times;1/04/2015;31/03/2017;;"Massive stars, i.e. stars that are up to million times brighter than ordinary stars such as our Sun, play many important roles in astrophysics. They can be considered as (I) Cosmic Engines as they transformed the pristine and dark Universe left after the Big Bang into the modern Universe in which we live today. We use them as (II) Cosmic Probes to study the most distant galaxies and we monitor their eruptions and explosions as (III) Cosmic Transients. As a result, various fields in astrophysics heavily rely on the input of stellar models. Unfortunately, the widely used models are out-dated: they consider massive stars to be single.

Recently, large observing campaigns with world-class telescopes provided quantitative showing that the large majority of massive stars will interact with a close binary companion (e.g. Sana & de Mink et. al. Science 2012). This project aims to investigate and quantify how binarity affects the many roles that massive stars played throughout cosmic time. Apart from a few pioneering studies, the exploration of these effects is still in its infancy. Progress has been hampered by (I) the challenging nature of the computations, (II) the many uncertainties in the models and until recently (III) the lack of observational constraints.

I propose to overcome these challenges by adopting an unique and innovative approach that combines the strengths of three highly complementary state-of-the art computational tools that will be confronted directly with observational data. I demonstrated the feasibility and high impact of this approach to derive the urgently needed constraints on the impact of binarity on stellar populations in exploratory studies (De Mink et al. 2013, 2014). In this effort I will strongly benefit from my large international network as well as the complementary expertise at the institute in Amsterdam.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195987;660707;Genocide accounting;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Accounting for genocide: legal and scientific accounting practices in the wake of the Srebrenica genocide;1/01/2016;31/12/2017;;Accounting for genocide empirically considers two sociomaterial practices of accounting for the 1995 Srebrenica genocide in Bosnia and Herzegovina. First, it scrutinizes efforts of national and international organizations to (ac)count how many Bosniak men were massacred and who was killed in July 1995. The second question about accounting analyses how those politically responsible at the time of the genocide are legally tried at the International Criminal Tribunal for the former Yugoslavia (ICTY). The first practice of accounting is based on inter alia forensic science, statistics, missing persons lists and witnesses conveniently subsumed under atrocity victim identification (AVI), the second practice is the domain of adversarial legal proceedings, developing international criminal law, transitional justice and controversies over the Srebrenica genocide and legitimacy of the ICTY. A rigorous qualitative analysis focusing on the various locationsmass-graves, family assistance centres, forensic laboratories, the ICTY, public domainwhere objects like remains, missing persons, identities, crimes, DNA evidence, and legal cases come to matter provides a deep understanding of the question of how both practices of accounting become entangled and co-construct each other.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;DE;;; 196082;661338;OPERACQC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Operational characterization of quantum correlations;1/05/2015;30/04/2017;;The proposed research aims at the operational characterization of features of correlations specific to quantum systems. This will lead to a deeper understanding of Quantum Mechanics (QM) and of the behaviour of correlated systems, and contribute to the development of revolutionary Quantum Information Processing (QIP) technologies. QIP applications include the efficient simulation of quantum systems, more precise sensors, secure communications, and, ultimately, incomparably faster computers. QIP was born from the recognition that information can be processed according to the laws of QM. At the core of the advantage of QIP over classical information processing lie quantum correlations, in which Dr Piani is an expert. Dr Piani will characterize several forms of quantum correlations in a systematic and unified way. The results will directly link to operational scenarios and applications, for example in metrology and communication. Where relevant, the characterization will take into account physical and practical constraints and limitations deriving from, e.g., the finite energy involved in physical processes and the necessarily incomplete information accessible to experimentalists. The host organization, the University of Strathclyde, will provide Dr Piani with the opportunity to establish a new research line in QIP at the Department of Physics, a stepping-stone towards a senior academic position. Thanks to his conceptual, mathematical and information-theoretic approach, Dr Piani will develop a research programme that will integrate and complement the research activities of the Computational Nonlinear and Quantum Optics (CNQO) group. As a member of the CNQO group, and especially through the collaboration with the supervisor Prof A. J. Daley, which is directed to the study and verification of quantum correlations in Atomic, Molecular, and Optical (AMO) physical systems, Dr Piani will develop and apply his expertise to AMO physics at the highest international level.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITY OF STRATHCLYDE;UK;;; 196039;661044;ID4;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role of Id4 in the adult subventricular zone of normal and injured brain;1/08/2015;31/07/2017;;The aim of this proposal is to propose a scientific research project and a training plan for Dr. Brenda Rocamonde. The scientific research project aims to understand the function of the transcriptional regulator Id4 in the adult subventricular zone (SVZ) under physiological and pathological conditions. The SVZ is one of the largest neurogenic niches of the adult brain, generating new neurons from neural stem and progenitor cells, throughout adulthood. This region is activated after brain injury, such as ischemic stroke. Inhibitor of DNA binding 4 (Id4) is a transcriptional regulator that acts by antagonizing transcription factors. In the developing brain, Id4 is required for neural progenitor cell proliferation and differentiation. However, the function of Id4 in the adult SVZ has not been reported. We have observed that Id4 is expressed in neural stem cells and cells of the neuronal lineage in the adult SVZ. We propose to use in vivo approaches to (i) determine Id4 function in the SVZ by loss and gain of function approaches, and (ii) evaluate its role in the response of the SVZ to ischemic stroke, a major cause of disability in Europe. This project, undertaken in an international research center and carried out by a talented fellow will provide insights into the mechanisms underlying the regulation of adult neurogenesis in the normal and injured brain. In addition, we are proposing a career development plan for Dr. Rocamonde that includes training on scientific and transferable skills. This plan will widen Dr. Rocamondes competences and provide her with the tools to become a leading independent researcher.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 195925;660322;NEDRATS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New Enantioselective Desymmetrization Reactions in Alkaloid Total Synthesis;6/07/2015;5/07/2017;;This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the daphniyunnine family of alkaloids based on a novel dual organo / metal catalysed desymmetrization reaction of alkene-linked cyclohexanones as a key step, which will allow the rapid and efficient construction of the AB rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different target molecules and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, Dr Sonawane, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 196095;661427;PHARM AD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Removal of pharmaceutical micro-pollutants from waste water by anaerobic digestion and its effect on nitrogen recovery from digestate by micro-algae.;1/08/2015;31/07/2017;;"Since the advent of the water framework directive (WFD), integrated pollution abatement and river water quality improvement has become a major focus in the management of water resources. At the same time, improving analytical capabilities and ecotoxicological understanding highlighted, somewhat counter-intuitively, new threats to water quality. Micropollutants in the form of pharmaceutical residues (PR) are one such emerging threat, and have been included in the most recent list of related WFD priority and related watch-list substances.
This research project will address this threat by application of a combination of existing and novel techniques: 1) investigate the efficacy of anaerobic digestion (AD) for the removal of these PRs not only in conventional treatment of sludges, but also on 2) the novel application of AD to the direct treatment of point source waste waters waste waters rich in these pollutants (e.g. hospital or industry), including feasibility studies on the transfer of membrane-bioreactor technologies from aerobic to anaerobic treatment. Furthermore, 3) the project will combine PR removal by AD with biological nutrient removal (nitrogen) by micro-algae cultivation, thus addressing one of the drawbacks of AD: the lack of nitrogen removal.
A particular inter-disciplinary perspective of this project is the inter-relation between 3 aspects of investigation: pollutant removal by AD, resultant ecotoxicological effects on algae and subsequently the recovery of nutrients by algae.
The final aim of the project is to elaborate the scope for river water improvement by these techniques, thus contributing to the European aims of water protection and resource efficiency. This element in particular will be supported by close collaboration with a German public water company, a UK SME from the water industry, and a French University, thus increasing the projects potential for impact and uptake due to generation of realistic and industry relevant outputs.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE GLASGOW CALEDONIAN UNIVERSITY;UK;;; 195972;660629;Art market;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The re-privatization of the contemporary art world: private collectors and artist-entrepreneurs in the changing geographies of European art;1/01/2017;30/06/2018;;"This project examines the idea that there is an on-going re-privatization of the European art world, in which increasingly it is private art collectors and communities of artist-entrepreneurs that are creating commercial value in the contemporary art market and redrawing our cultural landscape. The rapid expansion of the global art market has meant that art has entered a period of radical institutional, market and industry transformation. Private art collectors and artist-entrepreneurs are now competing with public institutions and the locus of power is moving from public to private actors. This change calls for new critical investigations of agency, value creation and creativity of the art world. My work addresses an area of activity that is central to both European cultural and economic development. The thriving European art scene is a key field within the creative and cultural industries identified as central to Europes development and integration by both the Creative Europe strategy and the Europe 2020 strategy.

With new and innovative empirical research, a program of training and knowledge transfer, and an ambitious dissemination plan I aim to contribute to important non-academic and academic debates over the geography and practice of the art world, by exploring how this re-balancing is changing how and where agency and value creation now takes place. Building on geographical analysis and ethnographies of London and Stockholm based private art market actors, I aim to develop new theoretical insights into: a) how and where arts commercial value gets created; and b) the increased presence of entrepreneurial and private actors strategies in the art world. This proposal involves the training and development of an experienced researcher through: i) time spent in one of Europes most innovative centres for human geography research; and ii) a new intra-disciplinary and comparative empirical research project.";146591,1;146591,1;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE;UK;;; 195965;660545;ARCSENN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ANALYSIS OF RC STRUCTURES EMPLOYING NEURAL NETWORKS;1/09/2015;31/08/2017;;The primary objective of the proposed project is to develop a radically new structural analysis procedure capable of accurately predicting the nonlinear behaviour of reinforced concrete structures. The proposed approach will be developed within the Soft Computing framework and as a result will require significantly less computational resources than those of more traditional methods of structural analysis. The proposed procedure will simulate each RC element, the beam-column joints included, with a single neural network, which has first to be appropriately trained. The training process will be based on the combined use of published test data, numerical predictions obtained from nonlinear finite-element analyses and the predicted behaviour of published physical models of RC structural elements at their ultimate limit state. In order to model intricate structures, the individual Neural Networks will be combined through a new solution strategy so as to provide a representative model of the structure considered. The stability and robustness of the proposed structural analysis method, as well as the validity and objectivity of its predictions, will be ensured through a comparative study of the predicted behaviour of RC frames with its counterparts established experimentally and numerically via nonlinear finite element analysis. Throughout these studies, attention will be focussed on identifying parameters affecting the overall structural response of RC frames (such as the effect of crack-formation within the joint regions) as well as their implications on practical structural analysis and design. Overall, the proposed work will lead to a stable, robust and computationally efficient numerical procedure capable of realistically and objectively predicting the nonlinear response of RC structures and suitable, not only for research and practical applications, but also for solving design optimization and reliability problems which require extensive parametric investigations.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HERIOT-WATT UNIVERSITY;UK;;; 195928;660339;eADAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ultra-small electrochemical aptasensors for specific dopamine real-time monitoring;1/02/2016;31/01/2018;;"Nowadays, over 1.2 million people in Europe live with Parkinsons disease (PD) considered as a complex disorder of unknown etiology, where an important number of cases are sporadic. In practice, the neurodegeneration associated with PD, also at the level of neurotransmitters (NT) misbalance, starts several years prior to the appearance of the cardinal symptoms. There are important evidences supporting that some environmental factors increase the risk of developing PD. Thus, there is the need of understanding their role and action mechanisms in order to develop therapeutic strategies and, even more important to minimize risks of PD development.
The main aim of this project is to develop an ultra-small electroanalytical diagnostic platform for highly-specific real-time monitoring of NT, such as dopamine (DA). Several methods have been developed in order to address this issue, but in general they lack either specificity or high spatial/temporal resolution. In this project we propose to exploit the ability of nucleic acid aptamers to sensitively and selectively bind/catalytically transform DA and develop an ultra-small array platform for DA monitoring in small biological environments. The importance is that it will be used to measure nM/?s DA release from PC12 cells and drosophila flies, examine the molecular mechanisms of neuronal function/dysfunction, and further correlated them to particular PD risk factors.
In a long-term perspective, the project aims microscopic sensors that may future be integrated with brain implants designed to restore local neuronal activity and/or NT release, such as deep brain stimulation electrodes, implanted to treat PD.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 195910;660211;InteractomeMalMot;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Interactome of surface proteins important for Plasmodium sporozoite gliding motility;15/05/2015;14/05/2017;;Sporozoites are the motile forms of the malaria causing parasite Plasmodium and are injected into the vertebrate host by a mosquito. Their motility is powered by the parasites own actin-myosin motor, which is connected to transmembrane proteins of the TRAP (thrombospondin-related anonymous protein) family which serve as force transmitters. This substrate-dependent locomotion is a prerequisite for tissue penetration and host cell invasion. The glycolytic enzyme aldolase was thought to be the link between actin and surface adhesins (reported in Mol Cell). However, recent data revealed that aldolase does not fulfil this role hence it is now unclear how the force is transmitted. Additionally, lack of the main surface adhesin TRAP was also found (by the host lab) to not block motility as previously reported (in Cell). Additional recent findings are challenging the model of how gliding motility works and thus highlight the importance to focus on novel proteins. One such new protein, LIMP has recently been identified in the host lab. Therefore, the principal aim presented in this proposal is the identification of the molecular function of LIMP, which shows an identical phenotype to TRAP. To this end I will generate a series of parasites strains expressing different mutated versions of LIMP which will be investigated using biophysical approaches. Moreover, I attempt to identify the proteins interacting with LIMP.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAETSKLINIKUM HEIDELBERG;DE;;; 196080;661323;CarboPlex;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of carbon-rich biochar-mineral complexes for soil amendment, carbon sequestration and beyond (CarboPlex);1/04/2015;31/03/2017;;Aim of this project is to investigate and exploit the potentials of a new material termed biochar-mineral complex (BMC). The simple yet ground-breaking idea is to use common waste streams to produce BMCs with distinct properties. Primary target is the use of BMCs as soil amender, especially in soils, where the delicate but crucial structure of organo-mineral complexes is threatened by unsustainable soil use or climate change. Where pure biochar is known to face its limits, BMC because of its mineral part is assumed to enable much higher functionality (i.e. water and nutrient storage). To provide evidence-based information on production, properties and soil effects of BMC, a systematic study will be conducted. The highly interdisciplinary work is split into five strongly interconnected work packages, which cover the whole BMC lifespan from production to soil use and technology assessment. Most of the work will be conducted at the University of Edinburgh (UoE). A secondment is planned at Enrich Environmental Ltd., an innovative Irish waste treatment SME, where the potentials and requirements for successful large-scale implementation will be investigated. Introducing this original work to the scientific communities (i.e. waste, agriculture, soil, material science) is expected to make enormous impact. Strong attention is also paid to dissemination of the results to the industry, other stakeholders and the general public. The ER, in addition to the expected excellent research, profits greatly from new experiences with pyrolysis (UKBRC) and business management (Enrich) supporting his strive for an academic career as professor. The UoE benefits from the ERs experiences in hydrothermal carbonization and gaining competence in BMCs. Enrich, in return, has strong interest to expand its range of products and to integrate innovative processes such as BMC production. Naturally, the ER, UoE and Enrich are strongly committed to the planed action and a most successful outcome.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195957;660495;NPA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Neurodidactics of Performing Arts: The Impact of Drama Teaching on Second Language Acquisition;22/06/2015;21/06/2018;;'Since the 1990s, Educational Neuroscience has become an emerging field of research which studies cognitive brain functions (thinking, memory, attention, emotions) and interfaces with the educational environment with the aim of improving teaching and learning. Simultaneously, 'Drama Teaching', a teaching methodology based on performing arts introduced in the 1970s, is now generating interest, especially in Foreign Language Learning. This research project will investigate aspects of cognition involved in the language learning process and it will analyse how Drama Teaching dynamics can impact language learning and proficiency. In order to define Drama Teaching as a methodology which involves the brain-mind-body dimension and fosters development of the learner as a whole person, a cognitive perspective will be adopted in relation to issues of a) embodied cognition, b) role of emotions in learning, c) impact of context and experience on learning d) cross-cultural identity process, development and awareness. Theoretical scientific investigation will be conducted on cognitive aspects relevant to learning, followed by the study and observation of dramatization practices. Development of curriculum and course implementation will follow. Particular attention will be given to the assessment of learning results and proficiency levels, as well as to the cognitive and emotional factors. The inter-disciplinary perspective adopted by this study is aimed at contributing to the debate on creative, interactive Foreign Language Education taking place in Europe and in the world. The scope is to contribute to the multi-disciplinary inquiries of Educational Neuroscience by elaborating a neuroscientifically grounded theory of Drama Teaching which gives educators guidelines to expand the range of teaching possibilities in accordance with the principles of Learning/Teaching of the Common European Framework of Reference for Languages.';250518,6;250518,6;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITA CA' FOSCARI VENEZIA;IT;;; 195982;660657;TMSP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mass accretion and ejection in transitional millisecond pulsars;4/04/2016;3/04/2018;;"The behaviour of matter under extreme conditions and the reason why accretion onto many astrophysical objects is accompanied by outflows of plasma like jets, are key questions of astrophysical research. Neutron stars (NSs) are prime laboratories for this investigation. They are the solid-surface bodies in which the most extreme conditions of gravity, density, pressure and magnetization are realized. When they are part of a binary system, and matter is transferred from their companion star, several phenomena occur which have shed light on the physics of mass accretion and NS magnetospheres, as well as the production of high energy radiation and pulsations. An important new class of pulsars spinning at a period of few milliseconds and switching between plasma accretion and ejection was discovered in 2013; they are dubbed transitional millisecond pulsars. These sources alternate between radio and X-ray pulsar regimes as a result of the interaction between the in-flowing plasma and the outward pressure exerted by their magnetosphere and radiation. They experience over few weeks transitions from a rotationally powered regime, in which they behave like radio pulsars, to a regime in which they accrete matter and emit intense high-energy radiation, like standard X-ray binary systems. In between these regimes these NSs display intermediate states which are still to be investigated in detail. Transitional millisecond pulsars provide us with a unique laboratory to study the interaction between the matter inflowing towards the NS, its rotating magnetosphere and the outgoing radiation, particle wind and jets. With this program based on multi-waveband (radio, optical, X-rays, gamma-rays) observations, we will exploit the diagnostic potential of these systems to (i) determine how outflows of plasma are launched and how they are coupled to the accretion process; (ii) measure their mass and spin to constrain their evolutionary state; (iii) study the formation of accretion disks.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ISTITUTO NAZIONALE DI ASTROFISICA;IT;;; 195950;660452;RyM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Experimental Studies of Strongly Interacting Quantum Gases in an Optical Lattice;1/05/2015;30/04/2017;;"Quantum gas systems have been recognized as quantum simulators that can directly compare theoretical models and experiments because of unprecedented experimental conditions. Here, we propose experimental studies on strongly interacting quantum gases in an optical lattice. The key ingredients of our research are the strong and long-range dipolar interactions from Rydberg excited states and two-component Bosonic atoms in optical lattices, which can simulate Heisenberg Hamiltonian.

Rydberg atom, having a high principle quantum number, engages in strong interactions because of its large dipole matrix element. Since the dipolar interaction of the systems can be coherently controlled and manipulated by laser light, we will investigate novel ground states of many Rydberg systems and realize many-body fast quantum gates. In this proposal, we introduce a supersolid phase in Rydberg systems, where the dipolar interaction can be tailored to a soft-core potential by off-resonant coupling. Moreover, studying coherent excitation dynamics of many-body Rydberg atoms, fast quantum gates can be realized in optical lattices. Finally, we propose a direct measurement of spin correlation function of anisotropic Heisenberg Hamiltonian in optical lattices by adapting the Ramsey interferometric technique.

Our research will extend the boundaries of atomic physics by demonstrating many-body quantum phenomena and offering a new systems to study quantum information science. Demonstration of supersolid will open a new chapter of superfluidity and can clarify long-debates about the existence of superflow in solid He-4. Moreover, our experimental techniques can be further developed to study more complex phenomena such as, spin liquid phase in Rydberg system and many-body localised state in disordered spin Hamiltonian. Through the successful demonstration of ground breaking experiments, the competitiveness of European Research Area will be increased.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195913;660220;EpiLIVER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization and implications of DNA damage response in liver cancer;1/01/2016;31/12/2017;;"Cholangiocarcinoma (CCA) is a devastating type of liver cancer that presents late, is difficult to diagnose and associated with a high mortality. Although worldwide the epidemiological trend is mixed, in the EU it has been steadily increasing for the last decade. Treatment is limited to tumor resection, which is not applicable in the vast majority of cases. The lack of any approved chemotherapy-based treatment is partially due to the poor understanding of the molecular mechanisms involved in the response to these drugs. Taking advantage of the comprehensive panel of established and primary CCA cell lines in the host PIs lab and my expertise on the DNA damage response (DDR) and repair field, my proposal offers a new approach in this scenario by characterizing the DDR of CCA cells. This study will be focused on the DDR-related chromatin remodeling SWI/SNF complex. In recent works, mutations in this family of proteins were identified in 47% of all CCA cases analyzed through whole exome sequencing, hence providing a relevant rationale in studying this complex. First, I will identify candidate markers of all known components of the SWI/SNF complex, based on RNAi high-throughput analysis. I will then perform direct and quantitative measurements of the DNA repair activity in CCA cells, specifically related to homologous recombination repair (HR) by rapid and sensitive reporter assays. And lastly, I will determine the proteome dynamics in the CCA context. There are two exclusive novelties on this approach: (1) the described novel methods will be employed in the Hepatology field for the first time; and (2) the use of primary CCA cells will enable me to directly compare observations in culture with clinical outcome. This proposal will not only contribute to the understanding of a limited understood area in liver cancer, but also holds great promises for future clinical use, where DDR-based drugs are the clinical mainstay";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195895;660138;Light-Trap;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A SiPM upgrade for VHE Astronomy and beyond;1/04/2015;31/03/2017;;"Ground-based gamma-ray astronomy in the Very High Energy (VHE, E>100 GeV) regime has fast become one of the most interesting and productive sub-fields of astrophysics today. Utilizing the Imaging Atmospheric Cherenkov Technique (IACT) to reconstruct the energy and direction of incoming gamma-ray photons from the universe, several source-classes have been uncovered by previous and current generations of IACT telescopes (e.g. Whipple, MAGIC, HESS, VERITAS).
The next generation IACT experiment, the Cherenkov Telescope Array (CTA) will provide increased sensitivity across a wider energy range and with better angular resolution. However, research into new and improved technology for potential upgrades of the CTA system are already being considered.
Improving the light-collection efficiency (hence reducing the energy threshold) and field-of-view of CTA cameras is high on the agenda of future upgrades. One may also consider increasing the number of telescopes if the cost of the cameras could be significantly reduced. The primary path to these goals is to replace PhotoMultipliers (PMTs) with Silicon-PMs (SiPM). These new photodetectors will also find multi-disciplinary use in e.g. in fluorescence telescopes for detection of Ultra High Energy Cosmic Rays and PET scanners in medical physics.
However SiPMs are not yet mature enough to replace PMTs for several reasons: sensitivity to unwanted longer wavelengths while lacking sensitivity at short wavelengths, small physical area, high cost and electronic noise. Here we propose a novel method to build relatively low-cost SiPM-based pixels utilizing wavelength-shifting material which overcome some of these drawbacks by collecting light over a larger area than standard SiPMs and improving sensitivity to shorter wavelengths while reducing background. We aim to optimize the design of such pixels, integrating them in an actual 7-pixel cluster which will be inserted into a MAGIC camera and tested during real observations.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTO DE FISICA DE ALTAS ENERGIAS;ES;;; 196128;661616;SOX10mutants;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating genotype-phenotype correlations in SOX10 neurocristopathies;1/07/2015;30/06/2017;;Neural crest formation is a critical event in development, giving rise multiple cell types including melanocytes, neurons and glia. This complex process is governed by a network of transcription factors, such as PAX3 and SOX10 and mutations in these genes have been associated with developmental syndromes. Waardenburg syndrome (WS) and Hirshsprung disease are examples of these neurocristopathies and patients suffer symptoms ranging from sensorineural hearing loss and pigmentation defects to intestinal aganglionosis. Over 50 case studies of WS have been reported in Europe and the incidence is estimated to be 1 in 42 000 people. Recent investigations into the molecular basis of WS have failed to identify genotype-phenotype correlations between gene mutations and symptoms, likely due to the in vitro nature of these studies. It has therefore become clear that new tools are needed to better understand the genotype-phenotype relationship in neurocristopathies in an in vivo context. The SOX10mutants project proposes to address this using a novel zebrafish rescue assay to investigate the effects of SOX10 mutations on the development of cell types deriving from the neural crest. Results from this study would impact significantly on genetic counselling and pre-natal screening of WS patients and provide proof-of-concept data for the use of zebrafish as a tool for studying neurocristopathies. This project is the basis of a multi-disciplinary collaboration between Prof. Robert Kelsh (University of Bath, UK) and Dr Nadge Bondurand (INSERM, France), bringing together zebrafish expertise with WS clinical genetics experience. The research fellow, Dr Deeya Ballim, contributes transcription factor knowledge and a diverse skill set. Deeya aims to establish an independent research group and this fellowship will be a key step in her career development, by expanding her research and academic training, supported by Prof. Kelsh and the University of Bath.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BATH;UK;;; 196065;661183;EPIGENHEART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Epigenetic control of retinoic acid-dependent genes during heart development;1/07/2015;30/06/2017;;EPIGENHEART proposes a unique and competitive training for heart development research centred on congenital heart diseases (CHD), a leading cause of death in Europe . Defects in the pathways involved in myocardial lineages at the venous pole of the heart are found to be the origin of CHD and atrial arrhythmias. Epigenetic gene regulation has influence in maintenance of cellular identity, differentiation, and is deregulated in many diseases. The involvement of epigenetic dysregulation in CHD is poorly described, much of the mechanistic detail involved in triggering these events in the context of heart development remains unclear. RA signalling is preferentially active in the venous pole region of the embryonic heart. A deregulation of the retinoic acid (RA) has been implicated in venous pole defects in patients. How RA signalling takes part in the genetic and epigenetic network regulating the venous pole lineage decisions needs to be studied in details. With the use of in vitro, ex vivo and in vivo approaches in transgenic and deficient mouse embryos combined with transcriptomic and chromatin profiling, the two interacting research lines of EPIGENHEART fulfils this goal. EPIGENHEART is expected to increase the knowledge on the genetic and epigenetic network regulating the formation of the venous pole, which will contribute to better understand the associated heart diseases. Apart from the impact on human health, the project will contribute to ERs future career prospects and European scientific excellence and competitiveness.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE D'AIX MARSEILLE;FR;;; 196024;660969;OsciLEDs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New Disruptive Platform Technology for Water Treatment and Process Intensification;1/07/2015;30/06/2017;;Millions of m3 per year of chemically and biologically contaminated wastewater from medical and specialty chemical sectors contaminate Europe water resources and has the potential to be reused using a novel cost-effective technology that developed in OsciLEDs. This proposal will evolve a disruptive platform technology for treatment of fluids (e.g. wastewater), which synergistically exploits two highly innovative processes: i) an oscillatory baffled column (OBC) and ii) wireless power of suspended UV light emitting diodes (WP UV-LEDs). This highly innovative combination intensifies the treatment of contaminated fluids by maximizing mixing and reactants mass transfer, while minimizing to the limit the irreducible volumetric irradiation gradients present in photoreactors. The synergistic effect of these two highly innovative processes will result in at least one-order of magnitude improvement in fluid effluent quality in comparison with the current state-of-the-art, an estimated 50% reduction of operational costs and one-order of magnitude reduction in reactor footprint. This is a completely new concept of photoreactor design, representing cutting-edge technological development for environmental applications, and in the photochemical synthesis sector (e.g., pharmaceuticals). Dr Lucas (Experienced Researcher, h-index 11, > 650 citations) has a significant background in the field of environmental remediation. Prof. Li Puma (PI, h-index 26, > 1600 citations) is a world leader in photoreactor design. During this project, an OBC recently commissioned and patented at Loughborough will be further developed to incorporate WP UV-LED sources. The performance of a new pilot-scale photoreactor will be evaluated for removal of emerging contaminants and for treatment of real hospital wastewater effluents. The purpose is to protect the IP generated and developing commercial prototypes for application in drinking and wastewater treatment, improving water quality and reuse.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LOUGHBOROUGH UNIVERSITY;UK;;; 195986;660695;DENE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dynamical effects on neutral excitations;1/06/2015;31/05/2017;;The aim of the present project is the development of a theoretical tool for the description of neutral excitations that are directly probed in absorption, electron energy loss and inelastic X-Ray scattering experiments. It is focused on the description of dynamical effects beyond the quasi particle picture that are not taken into account in the present theories. The final goal will be the correct description of the spectrum in systems where dynamical effects are not negligible as metals and strongly correlated insulators, the description of multiple excitations that are not included in a quasi particle picture and the understanding of the role played by electronic correlations on the lifetime of neutral excitations. Particular attention will be devoted to the problem of the multiple excitations in strongly correlated transition metal oxides.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195942;660402;HAAIV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Adaptive evolutionary pathways of highly pathogenic avian H5N1 influenza in humans;1/11/2015;31/10/2017;;Highly pathogenic H5N1 influenza viruses are endemic in wild birds and poultry across several Asian countries, and continue to cause human infections with high mortality. Global concern persists that these avian influenza viruses will evolve into viruses that can efficiently transmit between humans and may then cause a severe influenza pandemic. However, estimating the real risk of such a pandemic scenario is difficult due to limited understanding of the evolutionary requirements of H5N1 viruses to cross the species barrier and adapt to humans. There is therefore an urgent need to increase our insight into H5N1 influenza evolution within the human host and identify and characterize previously unrecognized adaptive evolutionary pathways. To gain this understanding we propose to apply whole genome, next generation viral quasispecies sequencing directly from serial clinical specimens obtained from H5N1-infected patients. We will perform an in-depth characterization of mutations that are selected during human H5N1 infections and include all influenza virus genes in our analyses. These analyses will provide insight into the diversity of H5N1 quasispecies and the molecular mechanisms of human adaptive mutations. This unbiased whole genome sequencing approach of the dynamics of within-host evolution of quasispecies during the course of infection in serial clinical specimens is highly innovative. The detection of minority variants that expand during the course of infection represents a unique approach to identify adaptive viral evolutionary pathways.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Academisch Medisch Centrum bij de Universiteit van Amsterdam;NL;;; 195935;660378;HOOKaWORM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Hook a Worm to Catch a Man: Tracking Historical and Recent Human Settlement, Land use and Migration in Neotropical Rainforests using Ecosystem Engineers;1/05/2015;30/04/2018;;"The anthropologic and archaeological study of pre-Columbian people of the Amazonian basin has revealed sophisticated agriculture practices. Notwithstanding the absence of historical written records the biological evidence of these practices remains in the remarkable biodiversity of the Amazonian 'dark earths' (ADEs) or Terra Preta do Indio produced by ancient civilisations to promote highly productive and sustainable agriculture. Promoting the interdisciplinary connection between anthropology, soil ecology and genomics the applicant will be able to investigate both the relationship of ADEs to the associated extant biodiversity, reveal details of past and current anthropogenic impact on the natural surroundings, as well as new clues regarding settlement dynamics over a large part of Brazil. The applicant and the supporting team will accomplish this by:
a) Assessing the current soil biodiversity assemblages to gain knowledge about the functioning and potential role of soil ecosystem engineers, organic matter and nutrients to the formation of these extremely fertile soils; this novel approach will aid in understanding the origin and sustainable management of ADEs as well as highly weathered and acid soils under humid tropical conditions.
b) Using DNA barcoding to describe the diversity of the ecosystem engineer community associated with past and recent Amerindian settlements throughout the Amazonian basin.
c) Using genomics of a peregrine species closely related with human landscape domestication to mirror the human exchanges and flow among the Neotropical rainforest associated with the migration of Amazonian Indians.
This will be achieved by integrating the state-of-the-art methods in invertebrate morphology, molecular genetics, and computational analyses with incorporation of pre-existent and new ecological, anthropological and environmental metadata sustained by a multidisciplinary collaborative network.";261599,4;261599,4;H2020-MSCA-IF-2014;MSCA-IF-GF;CARDIFF UNIVERSITY;UK;;; 196006;660911;VIOLA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Variability's Influence on Language Acquisition;1/09/2015;31/08/2017;;How is early language development affected by the number of speakers infants are exposed to in their daily lives? Some infants spend most of their waking time with only one person, while others hear many different speakers. These children receive quite different input. Even if the very same words are spoken, these words are pronounced very differently when not one but multiple people spoke them. Laboratory studies point to a significant effect of such variability in the context of a short experiment: When infants hear multiple speakers, their ability to recognize the same word is hampered, whereas learning sounds and words improves. It remains an open question whether long-term exposure to multiple speakers in daily life helps or hinders language acquisition, as current theories lead to opposing predictions. This project combines experimental approaches with computational modeling. It will shed unprecedented light on how speaker variability in daily life affects language development, a question that has substantial implications for theories of language acquisition and for current diagnostic practices.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ECOLE NORMALE SUPERIEURE;FR;;; 195939;660397;EmotionalActions;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding Emotional Actions;1/04/2015;31/03/2017;;"Emotions shape our personal lives and society at large. In Europe emotional disorders affect one in five people; it is the most chronic and second to most disabling health condition. The stakes to better understand our emotional behaviour are high; however there is still a lot to gain. Traditionally, emotions are thought to guide our behaviour either through fast instincts or deliberately selected actions. Current explanations of emotional health and disease frequently focus on one of these single components in isolation (or regard them as exclusive antagonists), but likely underestimate our emotional behaviours complexity and diversity.
Here I will investigate a complementary account: I suggest that in humans optimal emotional behaviour arises not from these instinctual and deliberate action selection systems individually, but from their interaction, mediated in our brain by a likely uniquely human prefrontal control system. First, using an innovative task, behavioural profiling, and formal computational modelling I will determine the influence and interaction of these systems in emotional behaviour. Second, I will use concurrent neuroimaging (fMRI) and neurostimulation (tDCS), geared at the prefrontal control system and its connectivity with amygdala and parietal cortex, to investigate their causal mechanisms during emotional situations.
This ambitious project combines my extensive experience in emotional behaviour with the world-leading expertise of University College London in computational neuroimaging and neurostimulation. These investigations are deliberately designed to both further our understanding of emotional behaviour and to initiate a path for improved treatment of emotional disorders in Europe. The computational modelling approach will elucidate hidden mechanisms and promote personalized diagnosis, while the modulatory neurostimulation approach will provide new avenues for targeted treatment ready to be developed in collaboration with the clinic.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195898;660149;BORCOM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Borylated Conjugated Materials;1/07/2015;30/06/2017;;Recent work at the University of Manchester has developed an efficient synthetic method for transition metal free electrophilic borylation of aromatics and heteroaromatics. This approach has recently been extended to the fusion of conjugated materials containing the acceptor moiety benzothiadiazole a group that is ubiquitous in materials for organic electronics. This functionalization leads to a significant increase in the electron affinity of the materials and a considerable reduction in the band gap, consistent with near-IR emission in organic light emitting diodes (OLEDs), ambipolar organic field effect transistor (OFET) mobility, improved n-type stability and effective light harvesting in organic photovoltaic cells (OPVs). The BORCOM project will use this methodology to deliver novel molecules and polymers that exhibit high electron affinities and small band gaps by functionalization of azole or azine containing acceptors in the conjugated backbone. The performance of the new materials as n-type semiconductors in OFETs, light harvesting and electron acceptors in OPVs and dopants/emitters in OLEDs will be evaluated.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 196049;661099;Athero MPh proliferation;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Macrophage proliferation and ontogeny in murine models of atherosclerosis;1/02/2016;31/01/2018;;"Atherosclerosis is a slowly progressing inflammatory disease that underlies some of the most common causes of death in western society. The central role of macrophages throughout its pathogenesis makes this cell an eminent target for therapeutic intervention. Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion of resident macrophages or even trans-differentiated vascular smooth muscle cells. The relative importance of these mechanisms to the pathogenesis remains however unclear, due to a lack of adequate animal models that allow assessing this question.
In this project, I introduce a recently developed fate mapping model, the LysMCre-Ubow\/\ mouse, into the atherosclerosis field to conclusively identify regions within the plaque that were formed through local proliferation rather than monocyte recruitment. Apart from quantifying its relative contribution to plaque growth during disease progression and regression, I will furthermore characterize the localization, transcriptional activity and the lipidic makeup of these proliferated cells versus invaded monocytes.
In a second part of this project, I will deploy adoptive bone marrow transfers from WT to Ubow mice and vice versa as a model to quantify intraplaque myeloid versus stromal-cell derived macrophages. I will compare proliferative capacity, phenotype, transcriptomics and lipidomics of these two subsets and link this information to their functionality.
With this strategy I will be the first to reveal the impact of the three macrophage accumulation mechanisms throughout the disease course, to couple this to their function and to exploit this knowledge for targeted experimental therapeutic interventions.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT MAASTRICHT;NL;;; 195981;660655;PALAEO;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Palaeolimnological assessment of methane emissions from lakes in changing environment using stable isotopes;1/09/2015;31/08/2017;;This proposal (PALAEO) aims to provide completely novel insights into the long-term dynamics of methane (CH4) concentrations and emissions from lakes in response to past climatic variation and anthropogenic impact. Lakes are an important component in the global carbon budget and their role as major sources of greenhouse gases, particularly CH4, has long been underestimated. This is partly due to the absence of long-term data sets of CH4 emissions from lakes, which makes predictions and modelling of lake ecosystem responses to future climate change extremely difficult. PALAEO will combine a unique experimental system, contemporary field observations and state-of-the-art palaeolimnology to develop, validate and apply methods to track long-term dynamics in CH4 in lakes. The different spatial and temporal scales are linked by a consistent methodology using stable isotope analysis applied to chitinous invertebrate remains, which have the potential to reflect past CH4 concentrations in the water. Sediment cores from the Arctic (Greenland), boreal (Finland) and temperate (Denmark) regions will be analysed. These cores also provide information on past environmental and ecological conditions, such as temperature, nutrient levels and community structure. Sampling from regions that have shown large climate variations (Arctic, boreal) and highly variable degree of human impact (boreal, temperate) will provide unique data for modelling how CH4 emissions from lakes will be affected under future warming scenarios. In addition, these data will allow the assessment of the relative importance of multiple pressures (climate warming, eutrophication) in driving the increases of CH4 emissions from lakes in different regions. This makes PALAEO a highly novel study linking change in the environment and ecosystem structure to long-term change in a key ecosystem process with global significance CH4 production and emission.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 195880;660053;COSMOVOID;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cosmology with voids and superclusters: combining theory, simulation and observation;1/10/2015;30/09/2017;;"The aim of this cosmology proposal is to study the contents, history and evolution of our Universe, using the distribution of matter on large scales. I propose to study new methods to identify and catalogue rare voids and superclusters in the large-scale structure of the Universe and to study their statistical, morphological and dynamical properties. I will use these studies to propose new observables and new techniques of data analysis based on these structures, and to use this knowledge to test theories of gravitation, dark energy and the initial conditions of the early Universe. Interest in cosmic voids in particular has increased greatly in recent years, as they have been suggested as extremely competitive probes of cosmology, according to some estimates significantly out-performing other methods. Yet there remain unsolved theoretical difficulties in the modelling of voids and even a lack of consensus on how to identify them and how to relate theory and observation. Even less is currently known about superclusters. These are among the important issues I propose to address. My proposal consists in roughly equal parts of: analysis of the latest high-quality survey data which will available from the Sloan Digital Sky Survey (SDSS) and the Dark Energy Survey (DES); analysis of the state-of-the-art Jubilee ISW and weak lensing simulations run on the Juropa supercomputer in Germany; and theoretical work to combine insights from data and simulation to improve our understanding of cosmology. The proposed work is to be carried out in collaboration with leading experts in the respective fields from across the European Community, in particular in the United Kingdom, Spain and Germany.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION;UK;;; 196118;661530;GeHa;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gemination Harmony;1/09/2015;31/08/2017;;"The goal of this project is to investigate long-distance anticipatory effects from word-medial geminates across three unrelated languages Italian, Tashlhiyt Berber and Japanese. In particular, it examines whether defining- and enhancing- features associated with geminates are already anticipated on the non-adjacent word-initial consonant (e.g., whether in the Italian [palla] ball the properties of the word-medial [ll] geminate are already foreshadowed on the word-initial [p]). In relation to the geminate-singleton distinction, Italian, Tashlhiyt Berber and Japanese present similarities (e.g. duration of the word-medial geminate consonant as primary correlate) and differences that are relevant for testing the following issues a) the type of length-related vs. strength-related properties that are spread from the word-medial geminate to the word-initial consonant; b) the domain of the harmonic process, and more precisely, the role played by the intervening vowel (e.g. the [a] in [palla]). In addition to the language factor, long-distance anticipatory effects induced by geminates will be tested against segmental factors (i.e. type of word-medial geminate consonant), prosodic factors (i.e. focus) and performance-related factors (i.e. speech rate). Two acoustic and articulatory experiments (measurements of tongue-to-palate contact and intraoral pressure) will be designed to address these issues. The main contribution of this project lies in determining the articulatory and acoustic bases of harmony as induced by gemination (gemination harmony) within a cross-linguistic perspective. As such, it may provide important insights into the interplay between phonetics and phonology and have crucial implications for the understanding of long-distance effects in speech production.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 196067;661191;Q-MoPS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum Molecular Photon Source;1/05/2015;30/04/2017;;"The development of a reliable photon source is vital for the development of new quantum technologies. There are many platforms currently being pursued to develop quantum simulators and quantum computers, but one point remains clear photons will be required to allow such systems to talk to one another; they are the only logical choice for quantum communication due to their low decoherence, ease of encoding and the fact that they do not readily interact with each other. In this fellowship project I will combine cutting edge photonic device engineering and molecular single photon emitters to build a reliable, scalable photon source. The organic dye molecule dibenzoterrylene (DBT) shows promise for use as a photon source with lifetime limited emission linewidths, a high quantum yield and an emission wavelength well matched to that of rubidium for interfacing with atomic quantum technology. I will interface these molecules with nanophotonic cavities and waveguides and utilise the advanced semiconductor fabrication capabilities of the University of York in a secondment phase to create novel, functional devices which will ultimately lead to the desired molecular photon source.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 196113;661515;SARTEA;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;SOLAR ADSORPTION REFRIGERATOR WITH THIN-LAYER/ENHAMCED ADSORBENT;1/04/2016;31/03/2018;;Increased energy costs, the uncertainty of fossil fuel availability, and climate change concerns, have necessitated the quest for renewable energy resources. Solar adsorption systems are quiet, simple to operate, and can last for a long time. However, they have low cooling power density, and subsequently have to be bulky compared to similar solar thermal systems offering the same performance. This can increase their initial costs, especially for small and medium sized systems, thus reducing their uptake. Currently researchers have successfully tackled this issue by, for instance, using more than one adsorbent bed to adopt a continuous cycle, and using forced cooling for the adsorber bed and condenser. These have not resolved the bulk/cost issues, however. This innovative Fellowship will apply a thin layer nano-particles embedded adsorbent, nano-fluid based refrigerants and selectively absorbing solar plate collectors to the system. We will develop a robust simulation model to help with the design process. The system will be partly built using a novel diffusion bonding process that enables dissimilar materials to be joined seamlessly. We will test the adsorption properties of the novel adsorbent materials and apply them to the refrigerator. We aim to deliver a solar adsorption refrigerator that employs nano-technology and novel manufacturing methods, meets the performance improvements currently achievable but not with the bulk and complexity. We expect scholars and industry to also apply the technology demonstrated to several other uses, and for them to be more accessible to the general public. The Fellow has all the necessary skills and experience required (including chemical adsorption, thermodynamics, heat & mass transfer) while the host lab has all the infrastructure and experience of hosting researchers. The project is also timely as it fits into the EU Energy policy (ESTPP Vision 2030).;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COVENTRY UNIVERSITY;UK;;; 195971;660618;Irish Merchants and Bordeaux;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Irish Merchants and Bordeaux: The Irish Role in the Invention of Grands Crus Wines;1/09/2015;31/08/2017;;"'This project investigates the creation of one of Europe's great cultural treasures: fine wine from Bordeaux. Modern historians have generally sought to explain the creation of Bordeaux grands crus as a result of wealthy English consumers whose demand for fine wine inspired and funded Bordelais wine-makers, or else the result of superior geography (terroir) and centuries of French wine-making skill. But these explanations, even when synthesized, overlook the necessary role of middlemen, the 'British' (in fact mostly Irish) merchants who 'raised' the wines in their Bordeaux cellars, blended them to their customers' tastes, and then got the wines to market in northern Europe. In many ways, these merchants were as much the 'winemaker' as the maitre de chai at the chateau. The importance of these merchants has long been acknowledged by French historians, but their role in producing the wines has never been fully explained. This project seeks to uncover the activities of leading wine merchants in the creation of fine Bordeaux wines, and to place those activities within a broader network of trade that was centered on Bordeaux and Ireland, but included Europe and the Atlantic World. In so doing, my project aims to show that neither terroir nor wealthy consumers--nor even a synthesis of the two--can explain the birth of fine Bordeaux wine; instead, the chain of causality must include the entrepreneurial skills of Irish merchants and vast networks in which they operated. Research for my project will be based in public and private archives in Ireland and France, and will result in a digitized database of merchants and their connections; lectures; and written publications. My project will fulfill the Individual Fellowship Programme by bringing a published expert in the history of wine to Europe; by strengthening ties between researchers in Cork, Bordeaux and the USA; and by highlighting the role of merchant innovation in the creation of a world famous product.'";187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;;; 196050;661103;NewPhysicsInSpace;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Indirect Probes of New Physical Phenomena in Space;31/12/2015;30/12/2017;;The ultimate goal of modern particle and astroparticle physics is to discover new physics beyond the standard model. Gravitation provides an infallible signal ofnew physics the dark matter (DM). Cosmic rays (along with DM direct detection and collider experiments) can shed light on the non-gravitational nature of the DM. Different spectral and spatial deviations of cosmic ray spectra from standard astrophysical predictions can hint possible annihilation or decay signals of DM. The aim of this research project is to work out constraints of the non-gravitational properties of dark matter using cosmic ray data from satellite based experiments like AMS02 and the Fermi LAT, and from Cherenkov, radio and neutrino telescopes. The discovery or exclusion of dark matter annihilation/decay scenarios and the extraction of the properties of DM from that data needs superb understanding of the standard astrophysical cosmic ray background. The proposed research will start with the study of standard cosmic ray backgrounds, including development of dedicated tools like DRAGON. As a new development, using the anticipated AMS02 data we study whether modification of standard cosmic ray production mechanisms in supernovae will be able to explain the observed positron anomaly. In collaboration with DESY and the Univ. of Cambridge the project continues with searching and constraining signals of new physics in charged cosmic rays as well as in photon and neutrino signals. The project is multidisciplinary combining studies of experimental data and theoretical research in particle physics, astroparticle physics, cosmology, astronomy, nuclear physics and astrochemistry. From the personal career perspective, the proposal would enable the applicant to return from CERN to the NICPB, Tallinn, and bring his gathered international research expertise to an EU country.;148582,8;148582,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KEEMILISE JA BIOLOOGILISE FUUSIKA INSTITUUT;EE;;; 195865;659950;INVENTION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;INnovatiVE cohereNt detecTIon Optical access Networks;1/04/2016;31/03/2018;;"In the called information age, digital communications play an essential role on the economy and sustainable growth of the society. Access networks are essential part of the communication infrastructure as bridge between end-users and core networks. Their design must make possible the provision of real-time high-bandwidth access to Internet, essential for advanced communication services as immersive video and ubiquitous cloud computing. It is clearly foreseen that the only long-term solution to the problem involves optical fiber as transmission medium, the so called optical access networks. Passive optical network (PON) is the most widely employed technology because of the cost reduction it entails, but the capacity of actual time-division multiplexed PONs will be exhausted eventually as more bandwidth-hungry applications become available in the near future. Telecommunications carriers face the challenge of meeting the unprecedented bandwidth demand by end users at the same time the capital and operating expenditures requirements are reduced.
INVENTION project targets the development of cost-effective and high capacity communication architectures for their employment on optical access/metro networks. The proposed concept will be based on the employment of coherent detection with low-cost and simplified optical receiver architectures, making sure that the proposed approaches meet the cost requirements of these optical networks. The proposed concepts will be implemented by a suitable combination of optical signal processing techniques and digital-signal-processing (DSP) algorithms, keeping the required DSP at realizable levels. The final scope of INVENTION is the proposal of mid-term and long-term solutions for the achievement of the objectives included in the digital agenda 2020 for the ICT strategy.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 196052;661122;TePaChe;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Temperature, Pathogens and Chemicals: Stressors in a Changing World;1/09/2015;31/08/2018;;"Despite the increasing number and multivariate nature of anthropogenic and natural stress, ecological research has primarily focused upon the effects of a single stressor on specific species or ecosystems. However, understanding relationships among multiple stressors and the mechanisms underlying stressor interactions is crucial for solving environmental problems. The proposed GF will address this topic by studying multiple stressors in a model system, filling knowledge gaps on the effects of simultaneous low temperature stress, pathogens and chemical challenges on animals. The proposed work combines theory and state-of-the-art methods from ecophysiology, ecotoxicology, immunology, evolutionary ecology and molecular biology, and has direct applications in environmental management and protection. The project uses insects as models, since they drive important ecological processes and are under high pressure from anthropogenic influences. Combinations of stressors will be explored under controlled conditions in a comparative multi-species approach in the fly genus Drosophila. The simultaneous application of the chosen stressors has not previously been comprehensively investigated, in spite of their relevance for management of both harmful and beneficial insects globally. The project has three aims: 1) to define the scope of tolerance against each stressor in isolation for each Drosophila species; 2) to identify potential interactions between the stressors and explore the predictability of the joint effects on performance and survival; 3) to investigate mechanistic underpinnings of possible stressor interactions. This project will establish a framework that allows me to extend my research deeper into the field and set the stage for a wider understanding of stress-related biology.";235285,2;235285,2;H2020-MSCA-IF-2014;MSCA-IF-GF;ITA-SUOMEN YLIOPISTO;FI;;; 196098;661434;BRCA2Interact;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural and biochemical characterization of pre-recombination complexes;1/06/2015;31/05/2017;;"Homologous recombination (HR) is an essential DNA repair mechanism and defects in different HR factors are linked with disease and cancer pre-disposition. The RAD51 recombinase plays a central role in HR, forming nucleoprotein filaments at sites of DNA damage and promoting homologous pairing and DNA strand exchange. RAD51 filament formation is mediated by the BRCA2 tumour suppressor, mutations in which lead to a high incidence of developing breast cancer. BRCA2 interacts with other HR factors, such as PALB2 and members of the RAD51 paralog family. Many of these proteins also function as tumour suppressors. The host laboratory has purified full-length BRCA2 protein and shown that it facilitates RAD51-mediated HR by acting as a molecular chaperone for RAD51 filament formation. This offers a unique position to extend our understanding of pre-recombinational protein assembly by inclusion of additional critical HR factors, and answer the important question how PALB2 and the RAD51 paralogs coordinate their activities with BRCA2 to promote the assembly of RAD51 filaments. To achieve this, I propose to:

i) Characterize the biochemical and structural properties of RAD51 paralog complexes
ii) Define the interplay between BRCA2, PALB2, and the RAD51 paralogs in forming pre-recombination complexes for RAD51 assembly, using biochemical approaches and electron microscopic visualisation.

Given the importance of HR and its role in tumour avoidance, I anticipate our results to provide significant new insights into the molecular mechanisms underlying genome instability. Also, they may uncover novel targets for therapeutic intervention for breast cancer. Together, the proposed research will not only substantially advance knowledge of DNA repair but will also provide me with invaluable training in biochemistry, electron microscopy and project management in a world-class research environment. As such, it forms the perfect platform from which to launch my independent research career.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE FRANCIS CRICK INSTITUTE LIMITED;UK;CANCER RESEARCH UK;UK; 196103;661479;MLGPIL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;POLICY INNOVATION AND LEGITIMACY IN REGIONAL MULTI-LEVEL GOVERNANCE;7/09/2015;6/09/2017;;"Multi-level policy-making between EU, national and sub-national levels has become increasingly complex. This has created the need for innovative governance solutions to address this complexity, which in turn has had an effect on political legitimacy. This project aims to address this topic by developing the linkages between procedural innovation in governance and the legitimacy of these processes in a multi-level political context, looking at how (or whether) political legitimacy can travel between governmental levels. The main research questions that will be addressed are:
1. In what ways does procedural innovation affect legitimacy in the multi-level context of the EU?
2. How do EU governance tools affect perceptions of legitimacy at Member State and regional levels?
The project will look at the effects of the EU-level Social Open Method of Coordination on Member State policies in the UK and Ireland, and what this means in terms of legitimacy at all political levels. A combination of literature review, discourse analysis, network analysis, interviews and statistical approaches will be used to assess legitimacy as citizen input, policy output and procedural throughput. It is hypothesised that EU innovation does act to improve throughput and input legitimacy at the EU levels, but fails to increase this legitimacy at national levels. However, output legitimacy in Member States is likely to increase due to EU oversight.
The work is highly relevant and innovative. It looks to disentangle serious questions faced by the EU in this age of Euroscepticism regarding legitimacy and democracy, showing how EU decisions are made, whether these decisions are seen to be legitimate and how this filters down to the national level. This research will help to disentangle the role of different governmental levels in both creating and receiving legitimacy derived from new governance approaches using innovative methodological and theoretical approaches.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SWANSEA UNIVERSITY;UK;;; 195850;659801;GENOLACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Consolidating a genomic framework for exploiting lactobacilli;1/06/2015;31/05/2017;;"Probiotics are defined as live microorganisms with a long history of safe use and a robust evidence for providing beneficial effects to the consumer. The majority of probiotic bacteria belong to Lactobacillus genus, which includes a large number of GRAS species, essential in fermented food production and for use as food preservatives. Lactobacilli have also a range of non-food applications, such as industrial production of lactate for the textile industry in environmentally friendlier ways than chemical synthesis.
Despite their broad use, health claims approval by EFSA for probiotics is challenging due to scientific difficulties in validating probiotic mechanisms and a lack of proper strain characterization. Although there has been a surge in research into probiotics, the conversion into actual claims and compliance with the regulatory requirements has proved difficult.
The aim of the project is to perform forensically detailed comparative genomic analysis of Lactobacillus species to i) unravel the genetic backbone that has been moulded by genome decay and gene acquisition ii) delineate the genetic features and molecular mechanisms that underpin their health-promoting effects and suitability for use, and iii) identify genes associated with the phenotypes for new food applications.
A deeper insight into the safety-related issues for food strains will provide a comprehensive assessment on risk factors to be transferred to companies as supplementary safety guidelines for successful health claim proposals. Data obtained will be used to develop new dietary solutions and safe non-food applications, thus increasing manufacturers interest in placing beneficial products on the market and meeting the consumers ambitions to live healthier.
Within the project, the applicant will have the chance to perform high-level research with leading scientists and create a link between academic institutions and companies for efficient technology transfer and novel industrial solutions.";187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;;; 195927;660331;BluGram;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Identification of genetic factors which determine host specificity in the wheat-powdery mildew pathosystem;1/09/2015;;;Powdery mildew caused by the fungus Blumeria graminis f.sp. tritici (Bgt) is a devastating disease of wheat with poorly understood plant-pathogen interactions. Sequencing of the Bgt genome indicated that hundreds of effector proteins are manipulating the plant cell and determining the virulence spectrum of a particular mildew strain. Bgt rapidly adapted to the introduction of the new host species bread wheat, which arose only 8,000-10,000 years ago. Bgt has since evolved into strains which are specialized on domesticated wheat and such which grow on wild wheat species. Genes responsible for the host specificity in an obliagte biotrophic fungus are unknown. To study the mechanisms of adaptive evolution in the highly repetitive Bgt genome, whole genome re-sequencing data of a mapping population derived from a cross between Bgt isolates that differ in their host specialization will be used to determine the frequency and distribution of recombination events and precise mapping of recombination breakpoints. Of particular interest is to study the impact of recombination on the clusters of effector genes. The factors that determine host specificity will be genetically mapped. This will allow conclusions on which and how many genes were responsible for the Bgt adaptation to the bread wheat host. The proposed research is taking a multi-disciplinary approach combining whole genome re-sequencing, classical genetics, molecular plant pathology and comparative genomics. This study will broaden our understanding of Bgt genome evolution and will help to design rational strategies for sustainable powdery mildew disease management.;260674,2;260674,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY OF HAIFA;IL;;; 196034;661024;GACD;SIGNED;H2020-EU.3.1.;Health;H2020;Global Alliance for Chronic Diseases Secretariat;1/01/2015;28/02/2017;;The GACD is the first collaboration of international research funding agencies, which aims to coordinate research activities that will address, on a global scale, the prevention and treatment of chronic non-communicable diseases with a particular focus on the needs of low- and middle-income countries (LMICs) and vulnerable populations in developed countries, with targeted support for researchers in and from these communities. The GACD Secretariat aims to coordinate among the GACD members the next GACD chronic disease research programme and the process for the call for applications, as well as coordinate among the GACD members and participating research teams the joint activities of the research programmes. The recommendations reached are expected to have a fundamental value for the future orientation of public health research policy.;180000;180000;H2020-Adhoc-2014-20;CSA;UNIVERSITY COLLEGE LONDON;UK;;; 195966;660554;Liver Bioengineering;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ex vivo Re-vascularization in Porcine Liver Bioengineering - A Critical First Step Towards Effective Transplantation of Bioengineered Livers;1/08/2015;31/07/2017;;Liver transplantation is currently the only proven therapy to extend life of patients with terminal liver disease. Organ bioengineering and regenerative medicine are promising new technologies that can help reduce the burden of liver shortage by increasing the number of organs available for transplantation. However, current bioengineered livers lack a functional vascular network that can readily allow their transplantation into a living host. Previous studies by the candidate have shown successful recellularization of acellular liver scaffolds using endothelial cells and hepatic cells in a perfusion bioreactor, creating a vascularized human liver organoid. However, its vascular network was unable to maintain vascular patency under constant blood flow for long periods of time. Hence, better understanding of how experimental cell seeding conditions of porcine liver scaffolds influence their re-vascularization efficiency is critical to achieve sustainable vascular patency after transplantation. In order to accomplish this, the impact of fluid flow pressure and the seeded cell number will be investigated in re-endothelialization efficiency of an acellular porcine liver scaffold. Furthermore, bioreactor pre-conditioning with fluid flow pressure ramping and sequential cycles of vascular growth and maturation will be used to induce re-vascularization, maturation, and enhanced function to potentially increase vascular patency. Finally, re-vascularized liver scaffolds will be transplanted into 5-10Kg pigs and short and long-term vascular patency will be investigated. Hence, the long-term objective of this project is to create a functional re-vascularized porcine liver scaffold, a critical first step towards the effective transplantation of bioengineered livers.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD;ES;;; 195991;660732;E-GRA-MONS OPTICS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Coupling Quantum Emitters to Graphene Plasmons: a new route towards fast Quantum Optics;1/03/2015;28/02/2017;;E-GRA-MONS OPTICS aims to couple quantum emitters (e.g. quantum dots and endohedral fullerenes) to the strong electric fields of graphene plasmons with the ultimate goal of performing fast quantum operations in the near infrared and visible spectrum. Such an integrated system will overcome the low processing speed of atoms and photons, thus providing a robust, solid-state platform for fast quantum optics. The real challenge is to integrate the features of quantum emitters and graphene plasmons into a single functional nanomaterial, understanding how the interactions at the nano-scale can impact its optical properties. To meet this challenge, this project adopts a multidisciplinary approach, combining the applicants experience in quantum operations using atoms and photons in conjunction with the world-leading expertise of the host organization in nanoscience and nanotechnology. The main objective is the experimental demonstration of strong emitter-plasmon coupling and plasmon-mediated interactions between emitters, which will be the fundamentals of novel quantum-optics technologies.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACION IMDEA NANOCIENCIA;ES;;; 195912;660219;NeuroEE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Delineation of a brain circuit regulating energy expenditure to impact body weight;1/02/2016;31/01/2018;;"Obesity is now a global epidemic with a significant and deleterious impact on human health. My career aim is to clarify the neural underpinnings of energy expenditure (EE) given that this makes a significant contribution to body weight. During my early career, I discovered a circuit linking the ventromedial hypothalamus (VMH) to brown adipose tissue (BAT) and inducing thermogenic beige (browning) white adipose tissue (WAT), regulating EE. Moreover, I found that the VMH-BAT axis is utilized by estrogen (Cell Metabolism, 2014) and nicotine (Diabetes, 2012) to increase EE and decrease body weight. My preliminary data indicate that a critical node between the VMH and BAT is the raphe pallidus (RPa), a brain region known to drive sympathetic tone to BAT. My immediate career aim is to clarify the neurochemical communicator receiving the VMH-EE related input and transmitting to BAT and browning. Given that the RPa is rich in the neurotransmitter 5-hydroxytryptamine (5-HT) which plays a role in thermoregulation, I hypothesize that 5-HT is a crucial component of my circuit. I propose to perform a Marie Sklodowska-Curie Fellowship (MSC) under Prof Lora Heislers supervision, arguably the global leader in 5-HT obesity research. Her laboratory is in the Rowett Institute of Nutrition and Health, University of Aberdeen, an Institute with more than a century of focused state-of-the-art obesity and nutrition research. This will supply an optimal environment for a MSC providing me with the opportunity to broaden my research interests, and allowing me to construct an international network of obesity researchers. A MSC will also provide the opportunity for me to be trained in transferable next generation engineered genetic technology that will allow me to rigorously and definitively test my current research hypothesis and to provide state-of-the-art expertise that will form a platform for my future career.
5-HT, brown adipose tissue, browning, raphe pallidus, ventromedial hypothalamus";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;UK;;; 196019;660954;BBP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bridging Belief and Practice;28/09/2015;27/09/2017;;The aim of the proposed research is to bridge the gap between theoretical and empirical studies of religion, which up till now developed separately, as the studies of beliefs and the studies of practices. This will be done by means of elucidating the properties of beliefs and their relation to human embodied religious practices. . I decided to take the best of empirical investigations (phenomenology and the most prominent results of religious studies) and the best of theoretical investigation (analytic philosophy) and make a conceptual work to bridge them. As a methodological basis for this work I have chosen embodied approaches, as they present a link between phenomenological descriptions and strict analytical conceptualizations. Body is a medium between beliefs and practices, thus the concept of belief will be developed in relation to the practice with a body as a focal point and a key source of conceptualizations. The results of the research will be presented in clear-cut analytical terms, easy to use not only by empirical and theoretical researchers of religion, but also by participants of interreligious dialogue, thus contributing to mutual understanding and religious tolerance. I aim to provide a proper, detailed and accurate account of the properties of beliefs in their relation to practice by conceptualizing the results of empirical studies in clear-cut analytical terms. This project is an important step in my professional development, as for its fulfillment I will have to apply all my previous knowledge and interdisciplinary skills, and learn new analytic methods.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195897;660147;PRe-FActo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Periodontal Regeneration through Femtosecond laser Action;1/01/2016;31/12/2017;;"The PRE-Facto fellowship aims to develop a new regenerative approach which potentially will promote the revival of the periodontium, while a successful outcome may lead also to the prevention of the disease when intervened early. Within my research I am going to develop a new biomaterial (calcium phosphates doped with ions of say, cerium and erbium oxides, fluoride and aluminum (3\) ions) with antibacterial properties which will be densified and bonded on the tooth surface after the irradiation with an ultrafast pulsed laser (femtosecond laser). In order to promote the attachment of the fibroblasts, the biomaterial will be mixed with collagen gel (or chitosan) while the effect of the surface topology will be also tested. For my research training as a bioengineer within which I aim to solve periodontitis as a global problem I will deal with the following Research Training Activities (RTAs); i) Synthesis, characterization and delivery of the biomaterial; ii) Sintering of the materials with femtosecond laser - characterization of the sintered area; iii) Cell culture and histological studies for exploring the regenerative potential of the material; iv) Toxicology tests and potential risks investigation.
This training is not only beneficial for the fellows scientific career development, but also for the host institute (the University of Leeds) and the general public health. The above listed training activities will be supplemented by a number of non-Technical skills for my career development. As a result of this cross-disciplinary project the fellow will be a well-rounded bioengineer researcher who in future will be become qualified for pursuing an academic career at the University of Leeds in the area of advanced drug delivery and photo-dynamic therapy using novel femtosecond lasers. Necessary research training and supervision at the UoL will be provided by the Engineering supervisor Prof. Animesh Jha (AJ) and the clinical supervisor Prof . Monty Duggal.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LEEDS;UK;;; 196012;660885;CENSZ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;CENSZ Critical Elements in Nonsulphide Zinc Deposits;1/07/2015;30/06/2016;;"The definition Critical Elements (CE) is assigned to those raw materials that are characterized by high supply risk and their high economic importance for the world/EU economy. Their high supply risk for EU is because Europe does not have enough primary resources of its own. The supply has to be satisfied by the global market production, which is often from geopolitically sensitive regions. It is recognised that recycling can only make a limited contribution to supplying European needs.
The central aim is to establish a comprehensive database of some of the most strategically important CE (Gallium, Indium and Germanium hereafter referred to by the acronym GIG) deportment within Nonsulphide Zinc (\Lead) deposits (NSZ) occurring within the Critical Zone of the crust, normally formed after the weathering and modification of Zn-Pb sulphide protores. These deposits have been exploited in the past in Europe (Italy, Belgium, Poland), and are currently exploited in several countries of the world, but they were never considered as a potential source for GIG even though some of the sulphide progenitors often contain these elements.";91727,4;91727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATURAL HISTORY MUSEUM;UK;;; 195835;659700;SCME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Selecting, Creating and Modifying Embryos: the ethics of new reproductive genetic technologies;1/09/2015;31/08/2017;;"For over three decades reproductive technologies have been available which allow parents to select between embryos based on their genetic makeup. Soon two novel ways of influencing a childs genome could also become available. In 2013, personal genomics company 23andMe received a patent to a technology called Gamete Donor Selection Based on Genetic Calculations. This technology would allow individuals accessing assisted reproductive services to choose between sperm or egg donors based on the likelihood of the embryos having a particular genetic makeup. Technologies like this allow parents to create rather than select embryos with desirable genetic characteristics. In addition genetic engineering technologies continue to improve. The recently developed CRISPR technique provides a more precise way of altering the genome than previous methods, and is the first modification technology with real potential to be used on human embryos. Technologies like this may allow parents to modify the genetic material of existing embryos.

These developments are seen by some as raising very serious ethical worries, and by others as promising to promote human flourishing. Therefore there is an urgent need to give them systematic ethical scrutiny.

If elected to this fellowship I will conduct a rigorous review of embryo creation, modification and section technologies and their ethical, political and philosophical implications. Built on an in-depth understanding of the science behind these technologies, my project will encompass an analysis of relevant philosophical and ethical issues, before delivering practical policy suggestions. This project will be the first extensive overview of the ethics of embryo creation technologies, the specific ethical issues raised by the CRISPR technique, and the moral and philosophical differences between embryo selection, creation and modification technologies.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195920;660280;SymPathInfect;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Symbiont-mediated defense of amoebae against Legionella pneumophila - molecular mechanisms and pathogen ecology;1/10/2015;30/09/2017;;Legionellae are opportunistic human pathogens infecting thousands of people annually in Europe. These bacteria are ubiquitous in many natural and man-made water systems, where they survive as free-living organisms in biofilms or intracellularly within a variety of protozoa. Free-living amoebae are the main route for spread and replication of legionellae in the environment, and infection of humans generally occurs via amoebae as vectors. Amoebae are frequently associated with bacterial endosymbionts, and recent data suggests that these symbionts interfere with replication of legionellae in amoebae thereby protecting the amoeba host from legionellae-induced lysis. The aim of this proposal is to further investigate this phenomenon of symbiont-mediated defense in protozoa, and to assess its implications for the ecology and transmission of legionellae. To shed light on the molecular and physiological interactions during infection of symbiont-containing amoebae with Legionella pneumophila, co-infection experiments will be performed and analyzed by state-of-the-art molecular methods including transcriptomics, proteomics and metabolomics, isotope profiling and chemical imaging techniques. Infection experiments will first be performed under controlled laboratory conditions to understand the interaction between amoeba, their bacterial symbionts and L. pneumophila, to analyse the molecular cross-talk, and to determine the mechanism of competition between the bacterial partners in this association. Subsequently, mesocosm experiments simulating environmental conditions will help to understand the impact of bacterial symbionts of amoebae on L. pneumophila spread and replication in the environment. Taken together, the comprehensive analysis of symbiont-mediated defense in amoebae will provide a new perspective on the ecology of L. pneumophila and lead to a better understanding of the role of amoebae and other microbes in water-borne disease outbreaks.;178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 196037;661035;KaMCAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Kac-Moody groups and Computer Assistants in Mathematics;1/08/2015;31/07/2017;;"This fellowship will enable the experienced Researcher Dr Rieuwert Blok - a currently USA-based European Union national - and Dr Corneliu Hoffman - as Host researcher based at the University of Birmingham - to carry out innovative and mutually beneficial research utilising their complementary skill sets. Blok brings extensive research experience in buildings, Lie theory and geometries while Hoffman's background is in group theory, representation theory and number theory. The fellowship aims to create optimal conditions for the Researcher to reintegrate into ERA for the benefit of both the Researcher and the ERA.

The action comprises two distinct, yet interconnected Work Packages.
The first one concerns Curtis-Tits groups, a large family of groups recently introduced by the Researcher and Dr Hoffman.
This family includes groups of established importance, namely groups of Lie and Kac-Moody type, but in fact contains many new groups of great theoretical significance and practical interest.
The action develops methods that open up this promising family for further study. It then determines key properties such as simplicity, and explores and establishes applications in geometric group theory, combinatorics, group presentations, and computer science. The subject area is an innovative blend of group theory, homological algebra, topology, geometry, number theory and computer science.

The second package is an interdisciplinary project between mathematics and computer science, exploring the promise of effectively using the recent developments surrounding proof assistants in teaching and research.
It builds forth upon pioneering work in this direction by both researchers at their respective universities.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE UNIVERSITY OF BIRMINGHAM;UK;;; 196083;661340;SOCIAL COST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Differential costs of social living in nature;1/02/2016;31/01/2018;;Group living is a common phenomenon in nature in a wide range of taxa. Studies in natural systems are central to understanding the evolution of social behaviour and systems. While benefits, such as reduced predation risk, and costs, such as increased pathogen transmission, are well documented for some species, many other effects of group living are poorly understood in natural populations. In particular, group size and composition, and individual social status might affect the level of social stress. Social stress can cause physiological stress in group living animals, including humans, leading to poor health or fitness reduction. The level of costs and benefits, as well as the optimum resolution of the resulting trade-offs, is likely to vary with social status and sex, but the nature of these differences is poorly understood. In this project, I propose to test in a free living sciurid rodent, the Cape ground squirrel (Xerus inauris), whether the costs of group living vary with social status, and whether this can be explained by physiological and molecular changes that influence longevity. To address these questions, I will use biomarkers of aging, involving hormone levels, oxidative damage and telomere loss. Combining the latest methods in measuring such parameters will provide a new understanding of how sociality influences stress responses in free-living mammals of different social status.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 196035;661025;SpTheoryGraphLim;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spectral Theory of Graph Limits;1/05/2015;30/04/2017;;"The need to understand the behavior of real-life networks made it necessary to work out non-standard graph theoretic tools capable of dealing with a large number of interacting nodes. New mathematical areas emerged, such as graph convergence or parallel algorithms.

The proposal suggests the study of the spectral aspects of these areas. The proposed research is built around two core problems that grew out of and are natural continuations of Harangi's previous work in spectral graph theory at the University of Toronto. One is a spectral version of the so-called soficity problem, a major open question in the area of Benjamini-Schramm convergence. The other is an ambitious conjecture of Harangi and Virag concerning eigenvectors of random regular graphs, stating that these eigenvectors converge to Gaussian wave functions.

In the past few years the Renyi Institute has become the European center for studying graph convergence with several experts of the field working there as well as many talented and motivated graduate students and postdoctoral fellows. Being a member of this research group will allow Harangi to collaborate with researchers from various different mathematical disciplines. The proposed research topic is at the meeting point of these areas. The host's expertise in groups and graph limits will complement Harangi's analytic skills.

The proposed fellowship would give Harangi an excellent oppurtinity to work with some of the top researchers in his field, to acquire the necessary tools to crack the exciting research problems proposed and to make the optimal next step in his career.";134239,2;134239,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAGYAR TUDOMANYOS AKADEMIA RENYI ALFRED MATEMATIKAI KUTATOINTEZET;HU;;; 195820;659633;CR-PHAGOCYTOSIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Complement-mediated phagocytosis in neutrophils;1/04/2015;31/03/2017;;Complement-mediated phagocytosis plays a crucial role in bacterial killing. Activation of complement yields a variety of opsonin molecules that can rapidly coat bacterial surfaces, which interact with complement receptors on neutrophils to facilitate phagocytosis. However the molecular details and functional outcomes of these interactions are not well understood. In the proposed work, we aim to elucidate the molecular details of complement opsonin-receptor interactions. We have developed a novel model for examining molecular complement interactions, by site-specifically attaching complement opsonins to bacteria-sized beads in their correct orientation. We will, for the first time, be able to adequately characterize complement opsonin-receptor interactions at a molecular level. This methodology will also be extended to two model gram-positive bacteria, Staphylococcus aureus (S. aureus) and Group B Streptococcus (GBS), in which complement opsonins will be site-specifically attached to their cell walls. Using wild-type and complement receptor (CR) knockdown neutrophils, we aim to determine the roles of opsonin-receptor pairs in neutrophil activation and bacterial killing. Finally, we will use our model systems to examine the synergy between antibodies and complement in neutrophil phagocytosis. The proposed work will provide a comprehensive picture of the role of complement in neutrophil phagocytosis. As the role of complement in human disease is becoming increasingly apparent, the need for new therapeutics is imminent. The work proposed herein paves the way for several therapeutic applications, including targeted complement-dependent cytotoxicity (CDC) immunotherapeutics in cancer and complement inhibitors for a wide array of age-related, autoimmune, and rare/neglected disorders.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAIR MEDISCH CENTRUM UTRECHT;NL;;; 195975;660607;IE2;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Inclusive Education for an Inclusive Europe: Examining Social Interactions, Dynamics and Friendship Networks of Students in Mainstream Primary Schools;1/09/2015;31/08/2018;;The overarching research aim of this project is to examine the social interactions, dynamics and friendship networks of all students, with an emphasis on those identified as having special educational needs, in mainstream primary schools. The IE2 project strives to understand how inclusive education is being implemented across three countries (US, UK, Cyprus) and contribute to the debate on how to create a more inclusive European society by providing rigorous research evidence and recommendations. The project sets out to achieve three main objectives. First, to develop an innovative and interdisciplinary methodology to understand the social interactions, peer relationships and friendships with the combination of advanced social network analysis and ethnographic methods. Second, to establish a social network analysis toolkit for schools to enable practitioners understand the social dynamics within their settings. Third, to develop a platform for visualizing large datasets within social sciences and humanities. It is anticipated that the project will generate a significant impact on both the educational and social sciences and the researcher in terms of reaching a higher position of professional maturity. This is a project that is innovative and interdisciplinary as it breaks the boundaries between social sciences and humanities and computational studies, mathematics and statistics.;251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY OF PLYMOUTH;UK;;; 195994;660753;NESIAC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanobody-enabled Structural Investigation of a G Protein-Coupled Receptor-Arrestin Complex;1/07/2015;30/06/2017;;"Although many thousands of transient protein-protein interactions (PPIs) are known, there is a disturbing paucity of high-resolution structures of the resulting complexes and the difficulties involved in experimentally determining these atomic structures remain essentially unaddressed.

The Steyaert lab has shown that cross-linking transiently interacting proteins, followed by immunization of llamas with this cross-linked antigen, causes the maturation of single domain antibodies called Nanobodies (Nbs). The Nbs bind composite conformational epitopes unique to the transient complex. Highly efficient selection methods can discriminate Nbs that exclusively bind the transient (non-cross-linked) complex from binders that bind to the dissociated monomers. Such Nbs will be instrumental to purify and solve the structures of PPIs that have been resistant to investigation by X-ray, NMR, SAXS or EM and for the functional analysis of these complexes within a living cell.

This ground-breaking technology will be validated with well-chosen case studies covering key PPIs of the GPCR transmembrane signaling pathway including parts of the arrestin interactome. During this project the fellow will establish a unique research niche by systematically applying her arsenal of learnt techniques to develop the next generation antibody?enabled methods for the structural investigation of the GPCR-arrestin targets. The ultimate goal of NESIAC is to determine the atomic structures of the most relevant transient associations of these signaling proteins. This will open up a new platform for realising the structural basis of the elusive GPCR regulation by arrestins.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;VIB;BE;;; 195956;660489;APTALAPS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigation of the interaction of mesenchymal stem cells with aptamer modified surfaces using Light-Addressable Potentiometric Sensors (LAPS);20/07/2015;19/07/2017;;"The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques.
The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020.
The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semiconductor processing and single cell analysis, expand his research network and gain skills such as project management and grant writing allowing him to develop an independent research career.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 196022;660960;NanoERA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanomaterials Ecological Risk Assessment: A study of the long-term effects and risks of nanoscale Iron Oxide used in plastic composites in the aquatic environment;3/07/2015;2/07/2017;;"The nanoform of Iron Oxide (n-Fe2O3) is a large-volume substance used in pigments. Nanoscale Fe2O3 pigments are used to a significant extent in consumer products such as household appliances made of coloured plastic composites. This application implies high probability of n-Fe2O3 release into the aquatic environment (especially during end-of-life processing of the plastics), where n-Fe2O3 may pose risks to freshwater and sediment organisms. Presently, very little is known about the biological interactions and the ecological risks of n-Fe2O3, as the available information addresses only short-term effects of pristine n-Fe2O3. Therefore, the goal of NanoERA is to develop concepts and methods, and to generate data to predict the long-term ecological effects and risks of n-Fe2O3 (fragments) released from end-of-life processing of a coloured plastic composite into the aquatic environment and to compare them to the pristine n-Fe2O3 used to produce the composite. In order to achieve this, the fellow will analyse how the physicochemical properties of the n-Fe2O3 (fragments) change in environmental (i.e. freshwater and sediment) and biological (cell culture) media and how these changes affect the biological interactions of these materials in aquatic organisms. The generated ecotoxicological effects data will be used to derive dose-response relationships and to quantitatively estimate the long-term ecological risks of the n-Fe2O3 (fragments).
In the process of achieving the NanoERA scientific objectives the Marie Curie fellow will obtain training in transferable and technical skills. The fellows qualification match very well to the research programme, which promises that NanoERA will produce excellent scientific results, which will be broadly disseminated to achieve significant and long-lasting impact on the European objectives for safe and responsible nanoinnovation.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA CA' FOSCARI VENEZIA;IT;;; 195905;660172;FLEXGENOME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Flexible Genome: understanding the genetic regulation of Phenotypic Plasticity.;15/04/2015;14/04/2017;;"In multicellular animals, complex phenotypic traits such as behaviour, lifespan and diseases are not only determined by genetic factors but also in large part by the environment. Understanding how genes and the environment interact to produce fundamental traits is a major question in biology. Many organisms are capable of expressing multiple phenotypes from a single genome when exposed to different environments. This widespread phenomenon is termed phenotypic plasticity (PP). The genetic programs needed to produce alternative phenotypes are encoded within a single genome, and environmental stimuli determine which form is expressed. PP is highly relevant in nature as it allows organisms to survive and reproduce successfully in variable environments. Nevertheless, the molecular and genetic mechanisms responsible for this flexibility are surprisingly poorly understood. Here, I will investigate the genetic basis of PP by applying advanced genomic and computational techniques to an ecological model of PP, the butterfly Bicyclus anynana. In particular, I will 1) identify the genetic programs that produce alternative phenotypes from a single genome; and 2) assess the potential for evolutionary change in PP by characterising genetic variation in these programs. I will do this by applying RNA-Seq and gene co-expression networks to an ecologically well-characterised insect and developing and integrating methods and concepts across disciplines. Combining my significant expertise on the model system with the host laboratorys outstanding track record in evolutionary genomics and bioinformatics, this project offers a unique opportunity for obtaining an unprecedented and long-desired insight into the genetic mechanisms of PP. This fellowship will train me in precisely the technical and analytical techniques that are critical for scientific progress in decades to come, and for my career development as a scientist within the European Research Area.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195951;660458;CP-RehOP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;"Responding or not responding to training; prediction of balance rehabilitation outcome from structural and functional brain networks in Cerebral Palsy.";1/03/2016;28/02/2018;;"When an injury occurs to the developing brain, as in Cerebral Palsy (CP), these children typically experience sensorimotor disorders such as muscle weakness, abnormal muscle activity, and ataxia. Poor balance control is a primary deficit in CP, which has a large impact on a childs daily life, since it is crucial for independent mobility and greatly affects the risk of falls. CP is the most common developmental cause of physical disability in the world, with a prevalence of 2-3 in 1000 live births. To improve their quality of life, adequate treatment is essential. However, studies investigating the effectiveness of balance rehabilitation in CP have revealed mixed results. This is due to two reasons. First, due to the various clinical scales and experimental measures available, each measuring different components of balance, it is very complex to diagnose balance control in CP. Second, it is currently unknown which are the underlying neural causes of poor balance control in CP.
Since the success of well-targeted treatment depends on this basic knowledge, a novel experiment is suggested that provides fundamental insights in both areas. I will investigate whether balance training can promote postural and gait balance control in CP children. Clinical and experimental measures will be combined to allow for the determination of the best diagnostic tool for imbalance in CP. Using diffusion kurtosis imaging and resting state functional magnetic resonance imaging, I will examine the structural and functional brain networks involved in balance control in CP and whether advances in balance control are supported by neuroplastic changes.
As some children will be less responsive to training, it is hypothesized that this innovative combination of behavioral and neurological assessments allows for the identification of the underlying causes of responsiveness, and, most importantly, the prediction of individual responsiveness based on medical brain images, using machine learning.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VUMC;NL;STICHTING VU;NL; 196068;661198;Amicrex;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of a Microwave Assisted Cell Disruption of Biomass and Extraction of Valuable Compounds;1/05/2015;30/04/2017;;"The combination of biomass valorisation, process intensification and green technology is an attractive research challenge for the European Community being in line with the Resource-efficient Europe flagship initiatives by optimizing the use of material, energy resources and gaining valuable products with lower impact on our environment and health. The AMICREX project accepts this challenge and aims to develop an integrated process design for future industrial implementation, where by-products from agro industrial processes (e.g. carrot peels) can be valorised by recovering high- value nonpolar components (e.g. carotenoids, well recognized natural pigments and widely used in the food and cosmetic industries) through a microwave intensified microemulsion extraction process. The AMICREX concept can be extended to address the challenges proposed by extraction of nonpolar metabolites, especially carotenoids, from other renewable biomass sources (e.g. Microalgae). The key aspects of the proposed technology are 1) avoid the use of hazardous organic solvents in nonpolar compounds extraction by using microemulsion as extraction media, and 2) improve extraction kinetics by microwave cell disruption method in order to liberate intracellular compounds and make them available for the subsequent extraction process.
The research will first focus on the evaluation on the laboratory scale microwave cell disruption and subsequent microemulsion extraction processes of the characterized biomass. Based on the so obtained process and system specifications the small scale process is aimed to be turned into an industrial design concept through process modeling and simulation.
The satisfactory implementation of the project will be achieved by filling the gap between multidisciplinary fields of natural sciences and engineering. Moreover, the interdisciplinary scenario between biomass cell disruption, extraction process and microemulsion technology will be established.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;;; 196020;660955;ALMP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Effect of Active Labour Market Policies on the Behaviour and Employability of Benefit Claimants;1/01/2016;31/12/2017;;This project studies the impact of Active Labour Market Policies (ALMPs) on the transition from unemployment to employment as well as on the behaviour of the unemployed. It will be based on two Randomized Controlled Trials (RCTs) and freshly-released data from the IZA Evaluation dataset. The RCTs are carried out with our partner organization, the British Department for Work and Pensions (DWP). In the RCTs, factors such as frequency of meetings between the unemployed and the job coach, content of invitation letters, will be varied at random across large samples of benefit claimants. In impact evaluation studies, RCTs help us to overcome several problems that would prevent us to make causal inferences. The design and analysis will benefit from methodological expertise built up in medical statistics, in which methodological issues that often receive less attention in economics have been dealt with more extensively. The project is also inspired by strategies developed in the literature on tax compliance and by methodological insights from sociology on survey design. In the last component, the project will consider data from cognitive tests developed in psychology and introduced in the recent behavioural economics literature to investigate whether there is heterogeneity in unemployment duration across people with different cognitive skills, and to check whether a completely different approach to investigate a similar research question as in the second component leads to similar results. The large sample sizes will give us a unique opportunity to study heterogeneous effects and make progress in profiling the unemployed, hereby making use of novel statistical techniques co-developed at the Department of Economics at the University of Sheffield. The project will shed light on an important, though under researched, topic in labour economics, namely whether or not interventions might become less effective the later they are implemented in the unemployment spell.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 196004;660940;KRF-CY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Kaehler-Ricci flow and Singular Calabi-Yau manifolds;1/07/2015;30/06/2017;;"Smoothing properties of the Kaehler-Ricci flow have been known and used for a long time. Attempt to run the Kaehler-Ricci flow from a degenerate initial data has been of great interest in the last decades. The bet result so far was recently obtained by Guedj and Zeriahi that were able to define the maximal flow for any initial current with zero Lelong number. This initial current will be smoothed out immediately. One example was also given showing that there might be no regularity at all in the case of Fano manifolds when starting from a current with positive Lelong number. However it is expected that the regularizing effect happens outside analytic sets. The first goal of this proposal is to prove such a regularity result.

In the last few years, Eyssidieux, Guedj and Zeriahi have shown that every Calabi-Yau variety admits a unique singular Kaehler-Ricci flat metric. Their work establishes the existence of such singular Kaehler-Ricci flat metric but it does not establish the expected asymptotic behavior near the singular points.
The main goal of my proposal is to study the asymptotic behavior and the regularity properties of these metrics/potentials near singularities. More generally, given a Kaehler-Einstein metric on a singular variety, it would be interesting to understand how we can relate the asymptotic behavior of such a metric near to the singularities of the variety.
Such a result would be of great interest also in theoretical physics. Indeed, since the seminal paper of Candelas and de la Ossa in the 90's, physicists have guessed that Calabi-Yau 3-folds with the simplest isolated singularities should admit incomplete Kaehler-Ricci flat metrics which near each singularitiy look like the conifold metric.

A related goal would be to go after the analogies by these singular Calabi-Yau problems in the singular G2 holonomy setting.

A possible strategy would be to try to develop the techniques and the ideas recently used by Lu and myself.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195805;659520;CONTESTEDWATERS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Contested Waters: Rio de Janeiros Public Water Supply and the Social Structuring of the City;1/05/2015;30/04/2017;;The objective of the project is to write a social and political history of colonial and imperial Rio de Janeiro (16th to 19th centuries) along the lines of its expanding water supply. It is based on the assumption that the access to and control of water were closely related to the social and political struggles and structures in the city. Although not particularly scarce in its occurrence, due to the special geological situation, water and the water supply have always been more contested in Rio de Janeiro than in many other cities. Therefore water, with its highly transient availability but continuous relevance for all parts of society, is a topic suited to uncover important aspects of urban history, for specific situations as well as for broader developments, and ultimately for understanding how European rule in the overseas empires was constantly and extensively challenged by local circumstances. Furthermore, the project will give a response to the theoretical question about the relevance and applicability of environmental history to other fields of history, and encourage a more reflected and socially engaged thinking about some of the most pressing problems of our current world: the property, control and management of water and harmful potential which can emanate from it.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195961;660524;hh;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Search for Higgs boson pair production;21/03/2016;20/03/2018;;Within two years of the discovery of a Higgs boson with a mass near 125 GeV, a set of properties measurements have confirmed, within current experimental/theory uncertainties, its Standard Model (SM) nature. Nevertheless, beyond the SM theories offer a rich phenomenology and exciting prospects for the discovery of New Physics in the Higgs sector. This project aims to observe physics beyond the SM in the Higgs boson sector through the search for Higgs boson, h pairs in the hh->??b bbar channel, which benefits from the large h-> b bbar branching ratio, efficient diphoton trigger, low backgrounds and excellent diphoton invariant mass resolution. Both the resonant and non-resonant production are considered. To this end, the proton-proton collision data collected by the ATLAS experiment at a centre-of-mass energy of 13 TeV at the Large Hadron Collider over the next two years, will be used and are expected to amount to 70/fb. The proposal to search for anomalous Higgs boson production and for heavy resonant states decaying to hh is original, and innovative methods in all aspects of the project will be employed. The results of the project, which will provide new information on the h self-couplings and the production of new resonances decaying to hh, will be interpreted within various theoretical frameworks, with emphasis in two Higgs-doublet models.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195941;660401;MOLMIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular Biology of Sulfide-Oxidizing Nitrate-Reducing Microorganisms Involved in Microbiologically-Influenced Corrosion;6/01/2016;5/01/2018;;Dr. Sven Lahme proposes to work with Prof. Ian Head at Newcastle University, UK, to study the Molecular Biology of Sulfide-Oxidizing Nitrate-Reducing Microorganisms Involved in Microbiologically-Influenced Corrosion (MOLMIC). Corrosion is a multi-billion Euro problem for the oil and gas industry. Microbiologically-influenced corrosion (MIC) in this sector is usually linked to souring of oil fields due to production of toxic and corrosive H2S by sulfate-reducing bacteria (SRB). Injection of nitrate into sour oil fields is a bioengineering strategy, which removes H2S by promoting sulfide-oxidizing nitrate-reducing bacteria (soNRB). However, recent reports involved soNRB in MIC due to incomplete oxidation of H2S to corrosive sulfur intermediates. The end products of soNRB metabolism vary depending on the ratio of sulfide to nitrate. This suggests that a predictive understanding of soNRB metabolism and appropriately adjusting the nitrate dosage can prevent the risk for soNRB-mediated MIC. MOLMIC will investigate the ecophysiological role of soNRB in oil field corrosion by using isolated cultures, specific enrichments and complex communities. It aims to i) understand the sulfur metabolism of oil field soNRB by gathering genomic and transcriptomic information through next-generation sequencing, ii) link different soNRB metabolisms to corrosion by monitoring corrosion rates and gene expression under various conditions and iii) evaluate soNRB MIC and countermeasures in complex communities by testing different nitrate dosing strategies and predictive genetic diagnostics. Dr. Lahme will expand his skills in microbial physiology and molecular biology acquired in Germany and will be introduced to petroleum microbiology, bioengineering and electrochemical techniques. New academic and industrial collaborations will emerge, which are both essential for becoming an independent and leading researcher.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 196008;660943;AccuCT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Accurate characterization of charge-transfer excited states;4/01/2016;3/01/2019;;Charge transfer (CT) processes play an important role in photosensitizers and photocatalytic reactions that have found great potential in solar energy conversion and enviromental remediation. Density Functional Theory (DFT) is the archetype method to perform all kind of computational simulations due to its favorable combination of efficiency and accuracy. CT processes are among the most difficult challenges for DFT and currently a reliable, efficient and size-extensive method is missing. The goal of this project is developing a new family of long-range corrected density functionals for the quantitative description of CT excited states that also achieves better global performance of other properties. The current approach employs a physically sound strategy based on using density-related properties to construct attenuating functions, avoiding the undesirable biases produced by parameter fitting. By correcting CT description, the new functionals hold the promise to extend its applicability to a wider range of properties and pave the way towards the development of all-purpose functionals.;239191,2;239191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA;ES;;; 195890;660113;SHOALS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Swift GRB Host Galaxy Legacy Survey: Understanding the Link between GRBs and Star Formation from the Nearby to the Early Universe;15/05/2015;14/05/2017;;I propose to carry out the Swift Gamma-Ray Burst Host Galaxy Legacy Survey (SHOALS), a multi-national, multi-facility, multi-wavelength e?ort to characterize the gamma-ray burst host galaxy population and how it connects to other star-forming galaxy populations at high redshift. Gamma-ray bursts represent invaluable tracers of the conditions in distant galaxies and provide a unique means of measuring the contribution of the faintest and highest-redshift galaxies to stellar mass assembly, yet we still do not understand what their progenitor system is or what environmental inuences cause GRBs to explode more frequently in certain types of galaxies than others. By intensively charactering a large population of uniformly-selected GRB hosts across cosmic history, I will disentangle the various factors that may inuence GRB production (chemical composition, starburst intensity, population age) and apply these results to better understanding how these violent explosions are produced and how we can use them to better understand the earliest phases of galaxy evolution.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195936;660388;CONTESSA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;COuNt data TimE SerieS Analysis: significance tests and sequencing data application;1/08/2015;31/07/2017;;"The aim of this project is to develop methods for analysis of time-series based on count data. For example, detecting significant differences between two count data time series would distinguish between two different models: one in which the two time series are interchangeable, and one in which the second sample is a modification of the first, i.e. the two time series are non-interchangeable. This will broaden the target of my project to general analysis of count time-series data such as clustering, classification, perturbations inference and machine learning over sequential count data. The project will focus on count data sets from ribonucleic acid sequencing (RNA-seq) time course experiments. The method I plan to develop potentially has promising applications in a variety of multidisciplinary fields where event-counting is required, such as economics and biology. In economics, examples include the number of applicants for a job, or the number of labour strikes during a year. In biology, recent examples include high-throughput sequencing, such as RNA-seq and chromatin immunoprecipitation sequencing (ChIP-seq) analyses. These examples are especially relevant to this project because the method I will be developing enables various features of organisms to be compared through tag counts.

I am enthusiastic about having the opportunity to be instrumental to a field where once developed this project will have a real impact in finding better treatments for patients with neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Alzheimers and Parkinsons Disease. Professor Neil Lawrence will act as the supervisor of the fellowship and will take over responsibility for my training and development. My fellowship experience will be enriched further through a six month secondment period at University of Manchester with Professor Magnus Rattray and through the opportunity to collaborate with SITraNs Professor Winston Hide and Biogen Idec Industry.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195979;660646;PRIME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Process Invigoration through Model Embellishment;1/09/2015;31/08/2017;;"The objective of this research project is to enhance business process (BP) model comprehension in European organisations through dynamic process invigoration. Analysis and improvement of BPs are key to organisations cost efficiency and competitiveness. A growing number of organisations in Europe implement BP management solutions to analyse and automate their processes. BP models are invaluable to define, control, improve and communicate BPs. BP models abstract a dynamic phenomenon in the form of a static representation, thus they are often difficult to comprehend. In this research, I aim at redefining the BP model comprehension problem and developing innovative solutions through a synergetic usage of process modeling and multimedia disciplines. In this way, models will be dynamically invigorated and presented to business professionals in a comprehensible manner. To fulfil the overall objective, related literature will be reviewed; BP model invigoration techniques will be designed for eight different embellishment components; the techniques will be evaluated through industrial experiments and field studies; an open source BP model invigoration tool will be developed; and results will be disseminated in European academy and industry. Eventually, organisations from various domains in Europe can utilize their BP models in a better way by using the freely available PRIME tool to invigorate their processes. This will create an opportunity to increase organisational efficiency throughout Europe. This project will contribute to my career development in many ways. I will obtain regular training on scientific and transferable skills through interdisciplinary trainings with my supervisor and other scholars, courses in research schools, and the preparation of publications. Collaboration and networking will be enhanced through joint studies with scholars and industry, enabled by the supervisors previous collaborations as well as my experiences.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VU;NL;;; 196053;661127;SUPERSOL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Solution processed low-dimensional oxide semiconducting structures and devices;7/09/2015;6/09/2017;;"Progress in thin-film transistor (TFTs) over the past 40 years has been based primarily on the development/processing of new materials and on implementation of innovative device architectures together with new material combinations. The SUPERSOL project is a highly multidisciplinary research effort that aims to develop the next generation TFT technology based primarily on solution-processable low-dimensional (ultra-thin) metal oxide structures. The most important aspects of the technology include; (i) the potential for low-cost and scalable manufacturing, and (ii) performance characteristics well beyond the current state-of-the-art. To achieve these objectives I will develop low-dimensional metal oxide superlattices (SLs) comprised of sequentially deposited (via solution methods) dissimilar ultra-thin metal oxide layers. Device fabrication will be performed solely from solution methods such as spin casting, dip-coating and ultrasonic spray pyrolysis at plastic-compatible temperatures (100-200C). By exploring the charge transport phenomena occurring at the critical 2DEG interfaces, I will be able to develop transistors with carrier mobility well beyond incumbent technologies (i.e. poly-Si TFTs with carrier mobility ~70 cm2/Vs).
The first part of the project I will investigate the critical conditions that determine the formation of 2DEG systems within the oxide SLs. Best performing oxide SLs will then be used for the fabrication of TFTs on arbitrary substrates including plastic. This work will form the basis for the second part of the project which will focus solely on the development of technologically relevant devices including: memristors and novel quantum devices by manipulating at will the nature of the 2DEG formed within these simple to manufacture oxide SL based devices. Evaluation of the technology reliability/manufacturability and potential for scale-up will be performed in collaboration with the Holst Centre during the agreed secondment periods.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195790;659437;HistoricEpi;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantiative Study of Major Historic Epidemics and Transitions to longer, healthier lives;1/10/2015;30/09/2017;;"Only 150 years ago, one in five Europeans died in infancy, life expectancy was 40 years, and the leading causes of death were infectious diseases: tuberculosis, smallpox, measles, pertussis, diphtheria, cholera, typhoid fever, scarlet fever. But in just a few decades beginning about 1880, life expectancy rose dramatically as infectious disease mortality plummeted. This 2nd epidemiologic transition, in which chronic diseases began replacing infections as leading causes of death, occurred well in advance of antibiotics and most vaccines. Many factors have been proposed to explain it, including improved nutrition, sanitation, clean drinking water, better housing and the emergence of social support systems.

Little has been done, however, to systematically rescue and quantitatively study historic health data and rigorously investigate the epidemiologic transition. I lay out here an ambitious, novel, interdisciplinary and feasible proposal to do just that. In the process, I will broaden my research scope from statistical modeling of historic pandemic influenza to all historic infections, understand the historical context in which the transition occurred, and master new concepts in dynamic disease modeling. Danish historic medical data are uniquely detailed and reach far back in time, and are uniquely suited for quantitative studies of long time series of morbidity and mortality, with the promise to further illuminate the epidemiology of important diseases including smallpox, cholera, and measles.

After 25 years abroad as a senior researcher at the National Institutes of Health and Professor of Global Health in the U.S., I now wish to return to my native Denmark. I had the honor this year to be elected to the Royal Danish Academy of Sciences and Letters, and receive funding to be a visiting professor at the University of Copenhagen, and trust this signals the beginning of my successful re-integration to European academia.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KOBENHAVNS UNIVERSITET;DK;;; 196005;660859;ECOHYDRY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Advancing dryland ecohydrology: factors and mechanisms determining catastrophic shifts;1/03/2016;28/02/2018;;The already fragile delivery of dryland ecosystem services to over two billion people is increasingly threatened by global environmental change. Understanding of factors and mechanisms that govern dryland dynamics and their response to changing conditions and pressure is therefore of utmost importance. The scientific aim of this Action, ECOHYDRY, is to address the ecohydrological processes that determine the stability, resilience and restoration potential of dryland ecosystems. The societal aim is to improve dryland management to navigate the risks and opportunities associated with global change impacts on drylands worldwide. ECOHYDRY will extend the theory of ecosystem structure-function relationships by focusing on the so far less-explored hydrological functions. ECOHYDRY will also contribute to the research field of catastrophic ecosystem shifts by investigating critical factors and processes such as functional diversity, ecohydrological feedbacks, and interacting pressures of different nature that have yet to be addressed. Part of the innovation in the project lies in a methodological approach that formatively couples mathematical models and manipulative experiments of dryland ecosystem dynamics. ECOHYDRY also seeks to systematically translate and share the research achievements through a novel participatory approach that effectively engages stakeholders in the knowledge management process. The multidisciplinary perspective adopted, combining dryland ecology, hydrology, and social sciences, ultimately aims to provide useful and scientifically-sound information to adapt and increase the resilience of dryland ecosystems to global change impacts, including reliable early warning indicators. In this way, this proposal directly addresses the two cross-cutting priorities of sustainable development and climate action established by the H2020 Work Programme and will reinforce the already large European competitiveness in dryland research and management.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195946;660432;Spiral DRAGNs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Here be Spiral DRAGNs;1/05/2016;30/04/2018;;"Until recently, it was thought that large double-lobed radio sources are always hosted by massive elliptical galaxies in the local Universe and that the merger phenomenon responsible for the elliptical morphology is also responsible for triggering the AGN. Consequently, the existence of spiral galaxies that host double-lobed radio sources (spiral DRAGNs) is inconsistent with leading galaxy formation models. However, these systems have been confirmed to exist, calling into question our current understanding of galaxy formation. This project aims to establish the role of these systems in galaxy formation: either reconciling their existence with current models or challenging the idea of the standard feedback model. I propose a multi-pronged approach to this project: First, I will study the parsec-scale environment in the immediate vicinity of the AGN and determine whether properties of the central black hole in these spiral hosts are similar to those of the black holes hosted by elliptical galaxies; Second, I will study the megaparsec-scale environment of spiral DRAGNs to determine whether their environment is responsible for their unique nature. I will achieve the first science goal using Very Long Baseline Interferometry (VLBI) radio observations. I will achieve the second science goal using a combination of archival and new data at multiple wavelengths. Together these two science goals will enable us to definitively determine whether spiral DRAGNs are a result of the intrinsic properties of the black hole, a result of their large-scale environment, or a combination of both these factors. Furthermore, I will exploit my role as lead for the Radio Galaxy Zoo project on spiral DRAGNs to find more of these sources. To-date there have been only four spiral DRAGNs detected. Increasing the sample size is imperative for testing the hypotheses that will be formed in the above two science goals, and enable statistically significant conclusions to be drawn.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195989;660718;VOLES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Is rodenticide use disrupting the natural autoregulation of vole populations?;16/11/2015;15/11/2017;;Humans modify ecosystems to maximise benefits from natural resources and as a result wildlife adapts ecological relationships. For instance, voles show multiannual population cycles and predators respond numerically, possibly limiting vole populations. Voles also damage crops and reduce food available for livestock. Subsequently, farmers respond using anticoagulant rodenticides (ARs) to control voles. That means indirect control of predators by secondary exposure or by reduction of food sources. Therefore, ARs will be acting analogously as a superpredator, impeding the natural autoregulation of vole populations. Here the Experienced Researcher will become an ecologist and ecotoxicologist and learn to use cutting-edge Bayesian state space models to determine the superpredator role of ARs in both predator and prey dynamics. To do that, he will work in the Universities of Franche-Comt (UFC, France) and Aberdeen (UNIABDN, UK), the Doubs Hunting Federation (FDC25), but also work hand-in-hand with farmers, stakeholders, etc. about vole populations in western Europe. He will also collaborate with small mammal work groups involved in research about small mammal surges. By combining multidisciplinary and intersectoral knowledge, the project will address the deleterious effect of pest control by poisoning ecosystems. In addition, it will show predation as one underestimated tool for pest control. By direct contact with interested parties, the Experienced Researcher will become fully involved with groups related to the hunting industry, among others, which will enable him to develop consultancy services about small mammal pests and control methods. He will also boost his research carrier and become a senior post-doc dealing with strongly applied issues of ecology and ecotoxicology with strong links between international research institutions, maximising the chances to get a permanent position.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITE DE FRANCHE-COMTE;FR;;; 195992;660742;PGEPP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Are there rules to the game? Patterns of Genome Evolution in Paleopolyploid Plants;1/04/2015;31/03/2017;;Polyploidy events (i.e. the process of genome doubling that gives rise to organisms with multiple sets of chromosomes) have had a strong impact on land plants diversification, adaptation and speciation. Genomic investigations have found that polyploidy is ubiquitous among angiosperms and have identified independent lineage-specific ancient polyploidizations. Traces of these polyploidy events are still present, although duplication events are followed by massive gene loss and chromosome structural rearrangements. However, the mechanisms/principles that govern these genomic changes following polyploidization are still poorly understood. Our project aims to overcome this limitation by analyzing genomic changes following polyploidization in three plant families among which two are of particular agricultural and economical importance. Specifically I will test if common mechanisms (e.g. presence of repetitive elements) are involved in chromosomal rearrangements. I will combine physical mapping approaches (molecular cytogenetic and optical mapping) and sequence analysis to characterize and compare genomic collinearity (synteny) between genomes of Brassicaceae, Cleomaceae and Solanaceae species. This work will improve our understanding of genome evolution by looking mechanisms of chromosomal changes and will improve synteny analysis between model plants such as Arabidopsis and more distant crops for homolog identification.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195926;660328;MultiNav;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multisensory Navigation: Harnessing the Power of Multisensory Processing Optogenetic Stimulation to Aid The Blind;1/05/2015;30/04/2017;;"In Europe 30M people are visually impaired (VI), 2.5M of which are entirely blind. Despite many efforts on the societal level, VIs are still left in the dark, when it comes to independent navigation. Neuroscience has the long-term potential to provide brain-prostheses, which circumvent damaged parts of the visual system. In the present project, we will investigate how spatial information can assist VIs during navigation by non-invasive and invasive information delivery.
We will make use of multisensory integration and optogenetic stimulation to investigate these questions in an animal model of navigation in the dark. Mice use their sensory hairs (whiskers) analogous to how VIs use their cane for exploring their local surroundings. During this tactile navigation VIs also utilize the sound generated by their cane to provide both spatial and material information about their surroundings, evidence for a multisensory strategy.
Specifically we will first investigate the effect of multisensory information on the neural representation of tactile information during natural exploratory behaviour. For this purpose we will provide sounds rapidly (<1ms) in sync with each surface contact of the whisker. These sounds are modulated by the animals distance to the object or will provide contextually relevant spatial information (e.g. distant targets). We predict that even soft auditory information will boost the usefulness of tactile information (inverse effectiveness) and allow faster behavioural judgments in a spatial task. Next, we will provide spatial information directly to the tactile cortex using optogenetic stimulation, emulating the functioning of future, spatial brain prostheses. We predict that animals will learn to integrate this additional information to optimize their navigation success.
In summary, our research will contribute to providing navigation information to VIs non-invasively and invasively, and thus further the ongoing efforts of inclusion in Europe.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 195875;660030;BARREL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Barrel Assemblies of Membrane Active Artificial Foldamers;1/08/2015;31/07/2017;;"Development of resistance by bacteria to antibiotics makes design of novel antimicrobial compounds increasingly important. As persistent cells often become slow-growing or dormant, strategies targeting their membrane are becoming more relevant. For several natural antimicrobial peptides function can be coupled to scaffolds with high sheet content. Toxic oligomers may assemble into hydrophilic or lipophilic sheet rich barrel constructs. However, this mechanism is not understood, greatly hindering rational development of similar compounds.
My main research goal is to reach insight into the structure-function relationships of the barrel molecular scaffold and to gain understanding of how its ability to protect internal parts from the environment may contribute to toxicity. To approach this problem, I aim to design and study foldamer oligomer assemblies. I hope to define the fundamentals of how peptide - lipid bilayer interactions govern formation of potentially toxic oligomers at a molecular level. This may be exploited for developing new antimicrobial compounds.
Foldamers are highly similar to natural peptides in terms of structural diversity, thus they are ideal model systems, in several cases showing antibiotic activity and enzyme resistance. The computationally designed, structures will be studied with experimental methods in model membranes. I have experience with theoretical (QM&MD) and experimental tools (polarized light spectroscopy). However, characterisation of solution phase membrane systems requires use of additional techniques and I aim to learn more into X-ray scattering methods (SAXS,WAXS). In the lab of Prof. Attila Bota, I will have optimal conditions to gain expertise with these. The Host Institute will also provide a professionally organized and equipped environment, where I would have excellent chances to be offered a tenured position. I expect that the results and the planned outreach activities will have a positive impact on EU research.";146239,2;146239,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAGYAR TUDOMANYOS AKADEMIA TERMESZETTUDOMANYI KUTATOKOZPONT;HU;;; 195921;660275;LoStPReCon;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Long-term structural performance of pre-stressed concrete bridges: A risk-based monitoring informed framework for life-cycle asset management;1/11/2015;31/10/2017;;"Recently, the re-assessment of the collapse of the Koror-Babeldaob Bridge (in 1996), a pre-stressed bridge built by the cantilever method, concluded that this was due to excessive deflections that appeared and grew non-linearly some years after construction. Interestingly, similar trends were found for a group of 56 similar bridge spans, raising the question whether such concerns could influence the maintenance and service life of a high number of pre-stressed bridges in Europe and beyond. Although individual material and structural factors have been researched, this problem can only be solved by integrating physical and probabilistic models and benefiting from the increasing use of monitoring data. This proposal aims to:
1.Review existing models for shrinkage and creep at specimen level,
2.Establish robust hybrid FE models for medium/long-term predictions,
3.Develop a novel monitoring approach based on Digital Image Correlation (DIC),
4.Formulate a time-dependent reliability assessment framework, addressing creep and shrinkage uncertainties,
5.Produce representative performance-time profiles for pre-stressed bridges based on the proposed framework and models.
The above will be demonstrated via a case study the Lezria Bridge possessing a unique combination of factors: (i) available monitoring data, (ii) pre-existing analysis models and (iii) an intimate knowledge by Dr. Helder Sousa, the researcher, of its construction and behaviour. The findings will be directly relevant to the growing number of bridges with this problem, enhancing the European knowledge and competitiveness in the global infrastructure market. For this, an interdisciplinary research and training programme has been set out, building on the researchers strong track record, expanding/honing his knowledge/skills, so that he can reach the forefront of highly qualified professionals able to solve problems in a creative/integrative manner, contributing to European expertise and wealth creation.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SURREY;UK;;; 196038;661041;OPTIC BIOEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Toward the comprehension of primary bioelectromagnetic interactions: real time non-linear OPTICal imaging of BIO-samples under ElectroMagnetic exposure;1/09/2015;31/08/2017;;Cell membrane permeabilization, involving its reversible or irreversible restructuring, under extremely short electric (E) pulses exposure (from hundreds of us down to few ns) has a key role in a number of clinical, preclinical, and medical research applications. Hence, the knowledge of its bio-physical nature and dynamics (i.e. formation and resealing processes) is crucial for an aware control of delivered protocols, and for predicting treatments efficacy under established biological (e.g. buffer conductivity, cell dimensions) and electromagnetic (EM) conditions (e.g. pulse duration, amplitude, shape). To understand bio-physical mechanisms underlying such a pulse-exposure permeabilization, an innovative and advantageous approach is proposed based on real-time molecular vibrational modes imaging using fast Coherent anti-Stokes Raman Scattering (CARS) of in vitro samples under such a stimulation. Hence, in the present Marie Sklodowska Curie Action (MSCA), a fast CARS microscope will be integrated with a suitable wide band in vitro electromagnetic field (EMF) exposure setup to study the role of membrane lipid reactions and interfacial water in the electropermeabilization phenomenon. This innovative CARS analysis will be supported by mass spectroscopy measurements to verify the appearance of corresponding chemical species, and by simulated E field and pore density distributions on the bio-samples. This last step is an attempt to correlate sample areas presenting the highest CARS signal intensity with the correspondent E field and pore density distributions. The program that integrates engineering, physics, chemistry and biology will allow a substantial progression in my career and network ability through the work on a completely innovative, multidisciplinary and inter-disciplinary subject in one of the most reputed bioelectric laboratory, where the applications of electropermeabilization in biology and medicine where first developed in Europe and worldwide.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195883;660064;GRAPHENERGY3;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Novel Electrochemical Exfoliation Approach to the Synthesis of Large Area, Defect-Free and Single Layer Graphene and Its Application in Fuel Cells;17/08/2015;16/08/2017;;Large area, scalable production of single layer and defect free graphene is important for its use in industrial applications. Currently, common methods used to prepare graphene include micromechanical cleavage, chemical vapor deposition, and chemical reduction. However, all these methods have their own shortcomings, for example, difficulty in scale-up or poor quality due to significant defects. To address this issue, in this project, we will focus on developing a novel electrochemical cathodic exfoliation approach to produce high quality graphene. Non-covalent edge-functionalization will be employed to open graphite edges. Upon a negative potential applied on the functionalized graphite electrode, H\ cations from protic ionic liquid electrolyte will be inserted into graphite interlayers and be reduced to hydrogen gas to further open the edge of graphite, which will facilitate the larger imidazolium cations to intercalate, expand and completely exfoliate graphite to single layer graphene. This cathodic exfoliation approach is nondestructive to the resultant graphene, and maintains its perfect structure and electronic properties, which will result in high electrochemical stability and benefit the performance of graphene-based fuel cell electrocatalysts. Finally proton exchange membrane fuel cells will be fabricated with graphene based electrocatalysts above and these are expected to exhibit high power density and long term durability, which may produce a promising future energy technology.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195964;660533;NANDEEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NANO-FIBEROUS CATALYSED FILTERS FOR DIESEL EXHAUST EMISSION CONTROL;3/07/2015;2/07/2017;;"Reducing diesel particulate matter (DPM) is a key research area for automotive OEMs in order to meet the more and more stringent emission regulations. Diesel particulate filters (DPF) are used in separation of carbonatious particles by mechanical filtration and subsequent burning of the DPM in order to avoid pressure drop by filter plugging. Since these materials burn at high temperatures (more than 550C) with oxygen while diesel exhaust gases temperature lies between 200 and 400C, a suitable catalytic material is required to promote the soot or DPM combustion. Thus, it is very important to develop suitable catalytic materials which are active enough to ignite the DPM at low temperatures.
This research proposal is aimed to 1) design and develop a nanofibrous structured catalytic material (Pr2O3 and Mn2O3) using a novel synthesis method to have functions of trapping and combustion of DPM, 2) perform detailed characterisation of the nanofibre catalyst, and 3) demonstrate the emission reduction potential of nanofiber catalyst coated DPF by engine testing. The special morphology of nanofiber structure catalysts will increase the contact point of the DPM and help in burning of the soot. Thus the catalysed DPF can reduce the exhaust particulate emissions and exhaust back pressure there by improving the engine performance as well. These will be demonstrated in running a legislative emission driving cycle on a transient dynamometer engine test facility at the University of Birmingham (UoB). The experienced researcher will bring a new research area in the development of nanofiberous catalyst for DPF to the UoB and the latest advancements in engine testing and emission measurement techniques in the Future Engine and Fuels group will be transferred to the experienced researcher as part of the knowledge transfer. The knowledge generated will be shared among the wide research community and public through various outreach programmes.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195775;659339;OLIGOBINPRO;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Non-canonical nucleoside incorporation into synthetic RNA-oligonucleotides: investigations towards the discovery of selective RNA-binding proteins;1/06/2015;31/05/2017;;The increase of life expectancy around the world comes at the unavoidable cost of a rise in the occurrence of neurological diseases such as Parkinsons as well as debilitating ones like cancer. These conditions prevent the possibility of a sustained quality of life and cost society vast amounts of money for the treatment and care of patients. It is the responsibility of scientists to find innovative methods of treating and eliminating these diseases, allowing for a healthier quality of life. Recently, RNA-binding proteins have been linked to biological processes leading to these diseases as well as the expression of genes relating to obesity. A plethora of natural chemical modifications in RNA fine-tune its structure, allowing for this specific interaction which regulates processes such as gene expression and the tuning of translation. Although these have been known for years, their binding proteins have not been systematically studied. The difficulty of the chemical synthesis of modified oligoribonucleotides represents the major bottleneck in this field. The overall aim of this project is to discover RNA-binding proteins which bind to the non-canonical modifications Am, Cm, Gm, i6A and ms2i6A which were identified in the mRNA of human cancer cell lines. These will first be synthesised and then incorporated into oligoribonucleotide strands mimicking natural mRNA. By incubating with cellular extracts, we subsequently aim to identify their binding proteins by tagging them with novel technologies and analysing them using mass spectrometric techniques. This project will inspire and offer unique training to Dr. Michaelides by exposing him to this multidisciplinary field where chemistry and biology meet, enabling him to embark on his own academic career. Furthermore, it will set the foundation for the better understanding of the mechanisms responsible for the aforementioned conditions, which will in the long term lead to the design of new therapies for their prevention.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195967;660565;MolNANOtox;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanomaterial surface interactions at the molecular level and their impact on ecotoxicity;5/10/2015;4/10/2017;;"As nanotechnology continues to advance at an exponential rate, new products are continuously introduced into the market for research and consumer use. Engineered nanomaterials (ENMs), the functional components in these products, are often specifically designed to exploit the unique properties that nanomaterials exhibit; however, there is a widespread uncertainty on how these new properties may also potentially translate into novel risk issues in the environment. In particular, their high specific surface area and surface reactivity may promote distinct interactions with organisms particularly at the lower trophic levels. This can depend on both the intrinsic and extrinsic properties of ENMs, and can be affected by the formation of an eco-corona, which is composed of environmentally derived macromolecules from the milieu in which the ENMs are exposed that adsorb to the ENMs surface. However, understanding these interactions at the molecular level and their mechanistic consequences are severely limited and technically challenging, requiring a cross discipline approach. This project aims to address this knowledge gap by uncovering the underlying mechanisms for the formation and persistence of eco-coronas on a range of ENMs by combining fundamental ENM chemistry, environmental toxicology, advanced optical and mass spectroscopy and imaging techniques. In particular, this project will apply surface enhanced spectroscopic methods to characterise eco-corona composition and evolution and how this affects ENM interactions with, and impact upon unicellular organisms. By correlating the eco-corona composition with uptake route (or accumulation at external membrane) and toxicity response, and by investigating how these ENMs are partitioned within model species, the project proposes to identify the molecular basis that determines the fate and toxicology of ENMs in the environment.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATURAL ENVIRONMENT RESEARCH COUNCIL;UK;;; 195931;660349;SFSASP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural and Functional Studies of ATRX- Syndrome Protein;1/09/2015;31/08/2017;;The eukaryotic genome is packaged into chromatin, which needs to be unpacked to provide necessary access by cellular factors for varied cellular functions. However, DNA can be rendered accessible by the action of energy-consuming chromatin remodelling proteins. One such protein is ATRX that harbours an N-terminal plant homeodomain (PHD) and a C-terminal helicase domain that confers ATPase activity and identifies ATRX as a member of the snf2 family member of chromatin remodellers. ATRX has been shown to localize in vivo with constitutive heterochromatin in pericentromeric regions as well as telomeres where it works in complex with DAXX for the deposition of the Histone3.3. Mutations in the ATRX gene give rise to ATR-X syndrome, a severe X-linked mental retardation syndrome often accompanied by alpha-thalassemia. Mounting evidence links ATRX mutations to cancer and to malignancies that depend on a telomerase-independent pathway of telomere maintenance called the alternative lengthening of telomeres (ALT) pathway, linking ATRX to aging. Despite these advances however, there is lack of understanding of the molecular mechanism of ATRX and of its role within these pathologies. The proposed research aims to investigate the structural and functional properties of ATRX, and to define at a molecular level how it interacts with DAXX to remodel chromatin. We will use a combination of biophysical techniques like NMR, Isothermal Calorimetry and western blotting to characterize ATRX interaction with partner proteins. X-ray crystallography, Cryo-electron microscopy and Small angle X-ray scattering techniques will be used to elucidate the structure of ATRX complexes. We will also design assays to measure the enzymatic activity of the ATRX snf2 domain by itself and in presence of DNA and/or its interacting partners. These studies will provide insight into a potential new mechanism of chromatin remodelling and will help us elucidate the consequences of disease-related ATRX mutations.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SUSSEX;UK;;; 196023;660964;ROSNPD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Selective vulnerability of neuronal degeneration in Parkinsons disease: the load of routine behaviour;1/01/2016;31/12/2017;;Parkinsons disease (PD) is characterized by striatal dopamine (DA) depletion due to loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc). Understanding the mechanisms underlying the onset and progression of SNpc damage is a primary unmet goal in PD research. Cell loss occurs earliest and foremost in the ventro-lateral region of the SNpc. Previous work defines anatomical factors determining the vulnerability of the ventro-lateral SNpc: their large axonal arborisations, bursting activity with high Ca\\ inflow, high oxidative stress and sensitivity to aging. However, all of these features are shared by SNpc neurons but neurodegeneration in PD begins specifically by the ventro-lateral tier. This DA depletion first occurs in the posterior striatum, which is involved and required for habit formation and routine behaviour. Indeed, the earliest motor features of PD are commonly associated with impairment of automatic movements. The striatum is well known to be engaged in learning and habit formation, a process that is DA dependent. Striatal DA is released phasically (SNpc firing related) triggered by emotional responses, whereas tonic dopaminergic modulation (non-SNpc firing related), predominates in routine behaviour. The precise mechanism whereby DA regulates the learning of a routine is not well defined but SNpc dopaminergic neurons are engaged in behavioural tasks showing an activation of their firing rate at the start of an instrumental task. This provides support to the notion that DA signals the onset/offset of a task and perhaps switching between tasks. In addition, they have a higher response to external stimuli (alertness, sensory) and to emotional behaviours (i.e. reward, salience). It is hypothesized here that in order to control the whole spectrum of a task, from goal directed to habitual, the ventro-lateral SNpc neurons are under higher functional demand, and the consequent metabolic overload makes them more susceptible to degeneration.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;FUNDACION HOSPITAL DE MADRID;ES;;; 195906;660187;ReaDoubt;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Reasonable Doubt: An epistemological and psychological approach;1/09/2015;31/08/2017;;"The purpose of this research is to shed light on the nature and dynamics of doubt and confidence in complex epistemic decision-making, through a study of the notion of reasonable doubt. While doubt is considered a rational virtue, waiting until complete certainty before accepting and acting upon a given hypothesis is unreasonable in many contexts. Given some evidential support for the hypothesis, the threshold beyond which acceptance rather than doubt is the reasonable option seems to depend on the decisional context (particularly the cost of a possible error): jurors in criminal trials should thoroughly consider alternative scenarios before convicting a defendant; doctors or policy-makers, however, may have to take action upon less strongly confirmed hypotheses, depending on the relative costs and benefits of action/inaction. Such a decision-theoretic view of reasonable doubt relies on the assumption that the consequences of an hypothesis are exogenous to the rational evaluation of its evidential support: one first updates ones degree of belief in view of the evidence, and then assesses whether, given the context, the hypothesis is beyond reasonable doubt (i.e. should be accepted and acted upon). But is it the case that agents degrees of confidence in a hypothesis, and their weighing of various pieces of evidence, are impermeable to the decisional context? Is the jurors actual belief independent from her having to bring a consequential verdict? This research aims to study the epistemological norms of reasonable doubt, taking account of the psychological reality of the agents reasoning. The main objective of the fellowship is to develop an original empirical research programme, testing the effects of the consequentiality of epistemic decisions on reasoning. This interdisciplinary project requires the candidate, an expert philosopher, to acquire experimental skills and knowledge in psychology, under the supervision of a specialist in the psychology of reasoning.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BIRKBECK COLLEGE - UNIVERSITY OF LONDON;UK;;; 195911;660212;Hi-SynVir;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High-throughput characterization of host promiscuity for precisely designed synthetic viral capsid;1/07/2015;30/06/2017;;"Traditional geographic ranges of insect pests are altered by globalization and climate change, resulting in emerging threats for natural ecosystems, agriculture and human health. It is urgent to improve our ability to swiftly develop targeted solutions to contain such threats, while minimizing unintended side effects on the environment.
Densovirinae are very small, single-stranded DNA viruses pathogenic to a variety of arthropods, including pythophagous caterpillars and grasshoppers, as well as disease vectors such as aphids and mosquitoes. Host ranges appear to vary considerably amongst even closely related densoviruses. A better understanding of the molecular mechanisms underlying virulence and specificity is necessary to evaluate the risk and opportunities associated with potential use in controlling natural insect populations.

We propose to discover these molecular determinants through the use of precisely designed libraries of viral genomes. We will leverage cost-effective and scalable DNA synthesis and sequencing technologies to generate high-throughput implementation and testing of precise molecular hypotheses. These will be informed by currently available knowledge and further deepened by bioinformatic analysis of natural sequences. We will produce ~106 controlled variants of the viral capsid as well as select viral regulatory sequence elements (enhancers, splicing and translation start sites). Resulting libraries will be subjected to multiplexed, deep-sequencing-based functional assays.

The scale of this approach will permit to reconstitute the sequence-structure-activity relationships required to relate viral genomes to host specificity and propagation efficiency. These data will support the development of models to predict the behavior of a viral genome in a new ecology, assess its potential for future evolution and inform the safe use of viral vectors for the targeted biocontrol of insect populations.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;;; 195977;660630;ICE-OTOPE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Weathering and nutrient export from subglacial environments: A novel stable isotope approach;2/11/2015;1/11/2017;;The Earths surface has been dominated by cycles of glacial advance for more than two million years. Processes occurring at the glacier bed exert a fundamental control on the release of bioavailable elements to rivers and oceans and the evolution of the Earths surface, hydrosphere and atmosphere. As global temperatures rise and ice-sheets retreat, it is critical to constrain the roles that subglacial weathering processes play in controlling global biogeochemical cycles. The overarching goal of this project is to investigate the redox conditions that control vital nutrient and elemental release through a study of glacial outflows from contrasting subglacial environments. I will achieve this goal using a novel multidisciplinary framework incorporating cutting-edge redox sensitive stable isotope proxies (Mo, Fe and Se isotopes) of iron and sulphur cycling and oxidation state to unique glaciated regions. Using a combination of archived samples and focused field campaigns I will study subglacial outflow environments that differ in bedrock geology, regional climate and type of individual glacier drainage basins (e.g. ice cap, ice sheet and alpine glacier) in order to evaluate the importance of these parameters in weathering processes and ultimately the release of bio-available elements from the sub-glacial environment to rivers and oceans. Key questions I am to answer are how is the release of bioavailable elements a function of the redox state of the subglacial environment? Which of the three key parameters plays the most significant role? To what extent is this reflected in the enrichments of elements in solid/liquid phases? and how does this affect biogeochemical cycling downstream and nutrient supply?;183454,81;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;University of Durham;UK; 195974;660598;APT-Met;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Atom Probe Tomography (APT) Metrology for future 3D semiconductor devices;1/08/2015;31/07/2017;;This proposal presents a training-by-research plan in the emerging and exciting field of Atom Probe Tomography (APT) and its application in analysing non planar atomic scale state-of-the art semiconductor nanostructures. Central to this project are the metrology and training advances needed to underpin the next generation of 3 dimensional (3D) device architectures based on atomically engineered materials and interfaces (e.g. FinFETs such as the Tri-gate transistor). Amongst the possible emerging 3D analysis techniques which meet industrial requirements in terms of 3D-spatial resolution is APT. However, within the semiconductor field APT as a characterisation tool is still in its infancy with many challenges unresolved from both a fundamental understanding perspective as well operational performance. It therefore remains prone to many artefacts and limitations such that one has not yet reached the robust analysis levels required for the semiconductor industry - i.e. qualitative versus quantitative information, high success yield, tight reproducibility and accuracy, and a full understanding of the data quality. Research on the exploitation of APT for advanced semiconductor devices is restricted as it requires simultaneous access to an (expensive) APT tool and advanced semiconductor technology. Thus, the number of trained researchers is limited. This project therefore aims to: (1) advance the APT technique and (2) complement the applicants expertise with substantial training and knowledge of the APT technique. Through detailed investigations into the phenomena most impacting on APT new insights which will feed into the needs of the semiconductor industry will be sought. The research and training activities are designed to enhance the future career of the applicant by broadening his technical skills in a novel research area that and increase his prospects for extended funding for future collaborative research projects.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;;; 195860;659920;ReACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A Realizability Approach to Complexity Theory;1/11/2015;31/10/2017;;"'Complexity theory concerns fundamental questions on the mathematics of computer science about the amount of resources needed to run programs or solve problems. The ReACT project will build on recent work in realizability models for linear logic to provide new characterizations of existing complexity classes. The end goal is to enable researchers to attack long-standing open problems in complexity theory by using mathematical techniques, tools and invariants from operators algebras and dynamical systems.
The 'complexity-through-realizability' techniques developed by the ReACT project will provide a unified framework for studying many computational paradigms and their associated computational complexity theory grounded on well-studied mathematical concepts. This will allow for comparison of complexity classes defined from different computational paradigms (e.g. sequential and quantum computation), as well as establish a theory of complexity for computational paradigms lacking such (e.g. concurrent processes).
The 'complexity-through-realizability' approach stems from established logical-based approaches of complexity theory and inherits their strengths. It furthermore improves crucially over them as it builds upon state-of-the-art theoretical results on realizability models for linear logic using well-studied mathematical concepts from operators algebras and dynamical systems. As a consequence, it opens the way to the use against the open problems of the discipline the many techniques, tools and invariants that were developed in these mathematical disciplines.
The ReACT project has two objectives. The first objective aims at establishing this new approach to complexity as an emerging and promising field of study which generalizes and extends previous techniques. The second objective is to investigate investigating how the mathematical methods and techniques derived from of our approach can be used to attack long-standing open problems in complexity theory.'";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195990;660721;3D-GATED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Three-Dimensional Graphene Architectures as Templates for Electrochemical Devices;15/05/2015;14/05/2017;;"3D-GATED will focus on the utilisation of graphene in a unique and precise way, in combination with functional materials such as MoS2 and MoSe2 to address the specific demands of the sustainable energy sector, focussing on electrode development for the hydrogen evolution reaction (HER). Specifically, 3D-GATED will synthesise, optimise, and translate to a functional device; custom designed free-standing 3D graphene architectures through chemical vapour deposition (CVD) on complex Cu constructs. 3D-GATED addresses the need for reproducibility, low gravimetric density, and long range conduction in electrochemical device electrodes. This will be achieved through a convergence of research progress; improvements in selective laser melting (SLM) of Cu; CVD of graphene on Cu; delamination of graphene from Cu; and doping of graphene with functional materials.
Growth of 3D graphene on Cu constructs will be analysed for quality and homogeneity using Raman spectroscopy (and mapping), x-ray spectroscopies, and electron microscopy. Exfoliation of graphene from the Cu constructs will be studied though chemical etching and electrochemical delamination. The free-standing 3D graphene architectures will be doped with functional materials before being analysed for suitability as electrochemical devices. Additional focus will be given to utilizing the synergistic effects of the 2D catalytically active materials, MoS2 and MoSe2, with graphene to form fully functional device architectures for the HER.
3D-GATED will make major advances in the use of graphene template materials for electrochemical devices, propelling the integration of these devices into the commercial sphere through Imperials diverse commercial partners.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195949;660449;Beta-splicenet;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ALTERNATIVE SPLICING NETWORKS IN PANCREATIC BETA CELLS;1/06/2015;31/05/2017;;Type 1 diabetes (T1D) is a chronic autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. The mechanisms by which autoimmunity is triggered and aggravated in T1D and the nature of the intracellular signals that decide beta cell fate between survival or death remain to be clarified. Alternative splicing (AS) is a complex mechanism of gene expression regulation and a potent generator of proteome diversity. It provides cells with an exquisite capacity to rapidly modify their transcriptome and proteome in response to intra and extracellular cues. AS affects more than 90% of human genes and has a major impact in many cellular processes, including cell survival and generation of new antigenic epitopes. There is a growing interest in the role of AS in autoimmune diseases but nearly nothing is known on its role in beta cells and diabetes. Recent findings by the host group indicate that pro-inflammatory cytokines change the expression of >30 RNA-binding proteins (RBPs) and modify AS of >3000 genes in human beta cells. Importantly, the host group has discovered that the diabetes candidate gene GLIS3 affects beta cell apoptosis by regulating the splicing of the pro-apoptotic BH3-only protein Bim. These findings suggest that AS plays an important role in the regulation of beta cell dysfunction and death by mechanisms that remain to be clarified. We hypothesise that pro-inflammatory signals activate splicing networks contributing to beta cell functional lost and death. We propose in the present project a systems biology approach that will combine RNA-seq, network inference and analysis of individual RBPs to characterize and validate inflammation-activated splicing networks in beta cells. The ultimate goal is to identify key splicing networks and mRNA splice variants that will be targeted by splicing-modulation molecules as a novel therapeutic strategy to prevent progressive beta cell loss in T1D.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE LIBRE DE BRUXELLES;BE;;; 195867;659969;HESFIRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Drivers and projections of global fire activity and intensity under future climate and societal changes.;1/08/2015;31/07/2017;;Vegetation fire patterns depend on environmental drivers that are expected to change in the future, including climate and the expansion of agriculture and associated fire practices into natural ecosystems. In return, fires have a major influence on vegetation distribution, the carbon cycle and climate. It is important to anticipate the result of these interactions on future ecosystem dynamics and carbon emissions, and to integrate these outlook when designing societal strategies for climate mitigation. Such an integrative approach is especially relevant to terrestrial policies (e.g. REDD), which could drastically modify global landuse patterns and thus the anthropogenic footprint on fire regimes. In a first stage of the proposed research, we will improve our understanding of fire drivers through innovative observation data assimilation methods. We will focus on depicting the influence of climate and fuel on fire intensity, and of human activities on fire incidence, which are well-recognized research priorities. In a second stage, we will deploy this knowledge in multi-disciplinary settings to provide the first assessment of future fire regimes under economic, agricultural and climate scenarios. We will use existing and new scenarios from integrated assessment models with particular attention to design experiments of maximum relevance to the environmental policy commitments of the European Union.;148635,6;148635,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;Instituto Superior de Agronomia;PT;;; 195760;659246;DPaTh-To-Adapt;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rethinking climate change vulnerability: Drivers patterns of thermal tolerance adaptation in the ocean.;1/03/2016;28/02/2018;;Climate change is having pervasive impacts on biota that is collectively resulting in a fundamental alteration of the structure, function and feedbacks within ecosystems across the globe. A major challenge for climate change science is to develop an understanding of the sensitivity of organisms to the changing environment, and try and find spatial, broad taxonomic or trait based generalities that will enable more accurate identification of regions and ecosystems at severe risk of climate change impacts (sensitivity hotspots) so that mitigation and adaptive management actions can be prioritised. There are, however, several challenges associated with predicting sensitivity hotspots. At the forefront of these challenges is our understanding of the drivers of organisms thermal tolerance thresholds, and the proximity of temperature thresholds to the local climate extremes and climate change projections, herein called thermal safety margin (TSM). This project merges concepts from physiology, ecology, evolutionary biology, biogeography and physical oceanography into an interdisciplinary conceptual framework that exposes inconsistencies among current paradigms and fundamental limitations to our understanding of the sensitivity of marine organisms to climate change. The conceptual framework presented here offers a testable, interdisciplinary model to address this knowledge gap. Specifically we ask the questions 1) How do patterns in thermal tolerance breadth and thermal safety margins vary throughout species geographical ranges? And 2) What are the environmental drivers, biotic traits and evolutionary factors that determine an organisms thermal tolerance? Through identifying the nature of thermal tolerance patterns and identifying some of the mechanisms influencing these patterns, this research aims to increase the accuracy and resolution of predictions of the sensitivity of marine biota to climate change.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195924;660306;FreshwaterMPs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The environmental fate and effects of microplastics in freshwater ecosystems;1/04/2015;31/03/2017;;EU member states are currently working towards the realisation of environmental goals specified in the Water Framework Directive (WFD), which aims to protect both human and ecosystem health. Microplastic particles (MPs) are emerging pollutants of increasing concern and are formed primarily when plastic waste degrades in the environment. The impacts of MPs on freshwater biota are not known, however, they may present a potentially persistent and ecotoxicological pollution problem. Accordingly, the goal of this project is to assess the environmental risk of MPs in freshwater habitats. To achieve this, a detailed investigation of MP environmental persistence will be carried out. This will provide environmental fate summaries for different polymer classes and enable the modelling of their degradation processes. This will be combined with laboratory studies to assess relevant sub-lethal endpoints such as reproduction, fitness, inflammation, and oxidative stress. As MPs are known to accumulate co-occurring organic pollutants, the toxicity of virgin MPs will be compared to MPs conditioned with relevant freshwater pollutants. This work will build towards a sophisticated state-of-the-art mesocosm study that will evaluate both MP fate and impacts in model ecosystems. The establishment of a novel framework for the environmental risk assessment of MPs will inform our ability to achieve conservation objectives taking into account MPs as emerging pollutants. The merit of this is that protection goals may be better accommodated in policy and management through the generation of so far unavailable data on MP persistence and environmental toxicity. Taken together, the project will generate so far unavailable data sets to assess for the first time the environmental impacts of freshwater MPs. Thus, the outcomes will highly relevant for academia, politics, stakeholders and society.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;DE;;; 195882;660061;NCDIFFGEO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Models of noncommutative differential geometries;1/02/2016;31/01/2018;;Quantum spacetime is the idea that spacetime coordinates are not classical variables but elements of a noncommutative 'co-ordinate algebra' much as in quantum theory. The first convincing models of (flat) quantum spacetime appeared in the 1990's, typically on the basis of quantum symmetry using the then-new theory of quantum groups. The thinking is that such noncommutativity should arise from quantum gravity effects and allows us to model these in an effective description without full knowledge of quantum gravity itself (this not being known). Such flat quantum spacetimes are an area of existing strength for EU science. The project proposes a new generation of quantum spacetime models no longer tied to quantum symmetry. Instead the Marie Sk?odowska-Curie Fellowship will train an experienced Researcher coming from theoretical physics in new highly algebraic tools which are not easily accessible to physicists and which amount to a mathematical theory of 'noncommutative Riemannian geometry' including quantum differentials, quantum metrics, and quantum-Levi Civita connections and quantum curvature. The realisation of the project will validate and enrich the mathematical formalism and also promises a next generation of physical effects related to the conjunction of both gravity and quantum noncommutativy, which will stimulate original and creative approaches to quantum gravity across several EU institutes. It will also greatly enhance the competitiveness of the Researcher in complementing her knowledge of theoretical physics by mathematics (noncommutative differential geometry) which will put her in a seminal position for subsequent work. The quality and ambition of the research objectives, the possibilities of interdisciplinary collaborations and the international recognition of the Supervisor will further enhance the action and the Researcher's career.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 196089;661362;LV-Pri20;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Logic-based Verification of Privacy-Preservation in Europe's 2020 ICT;22/06/2015;21/06/2017;;"In line with the EU 2020 Flagship Initiative on a Digital Agenda for Europe and the upcoming EU Cybersecurity Strategy, the goal of the LV-Pri20 project is to aid our ICT-driven lives, by safeguarding the human right of privacy in the digital society. Concretely, the main focus of LV-Pri20 is the formal and automatic analysis of privacy-preservation in todays ICT. LV-Pri20 will focus on the prevalent wireless media, e.g., RF-identification protocols, remote car-unlocking, wearables, machine-to-machine communication in the Internet of Things (IoT)/ubiquitous computing, but it will not neglect wired environments (given their common cloud-connection).
LV-Pri20 will assess and automatically analyse privacy-sensitive applications, in their standalone execution, as well as in the more involved setting of multiple, concurrent executions thereof. This will be done systematically and taxonomically: distinct classes of applications (e.g., identification protocols using Electronic Product Codes vs. the Open Smart Grid Protocol) and different privacy properties (e.g., data non-leakage vs. data-user unlinkability) will be respectively analysed via tailored, well-defined techniques.
To specify privacy, LV-Pri20 will design/refine different non-classical logic languages which have inherent semantics for privacy-like expression (e.g., strategy logics). For these, we will then develop new model checking algorithms. All will be incorporated in automatic verification software, which already proved efficient in analysing highly distributed systems, inline with, e.g., the IoT applications envisaged herein.
LV-Pri20 will have a multi-disciplinary, collaborative nature, an academic core and industrial side. After an initial privacy scrutiny, new/patched RFID-based, privacy-preserving, communication protocols will be (re-)designed and implemented. For these, we will devise mathematical proofs for one-session security, and run automatic analysis of their multi-session executions.";195454,81;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITY OF SURREY;UK;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK; 195916;660231;SpinMan;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electrical Spin Manipulation in Atoms and Molecules;1/09/2016;31/08/2018;;In the proposed project Electrical Spin Manipulation in Atoms and Molecules (SpinMan), the experienced researcher Dr. Andrea Droghetti (Trinity College Dublin , Ireland) and the scientist-in-charge Prof. Angel Rubio, Head of the Nano-Bio Spectroscopy group at the University of the Basque Country (Spain), aim at establishing how an electrical current can be utilized in order to write and read information in a spin state of an atom or a molecule. This study will be carried out through simulations performed with a computational platform, which will combine recent theoretical developments in density functional theory for open systems, many-body physics and time-dependent methods thus bridging the gap between complementary approaches to quantum transport. The results will represent an important step-forward in understanding the basic physics of magnetism and spin dynamics at the nano-scale as required in order to provide, in the long term, new concepts for classical and quantum information. The skills in many-body physics and time-dependent simulations that the researcher will develop during the project, combined with his background knowledge in magnetism and with the acquired experience in networking and management, will be essential in order to advance the researcher's career as independent investigator.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA;ES;;; 195952;660468;FORGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;From new Objects to new woRds through GEstures: how sensory-motor experiences of objects and tools influence word acquisition in children;1/02/2016;31/01/2018;;A key question in language studies is how children learn the meaning of new words and corresponding concepts. Developmental studies show that childrens actions promote learning about new objects and that acting on objects is closely related to early gestures production, which in turn accompanies vocabulary acquisition. Brain imaging studies have found activation of motor areas when people process action-related words. Together, these findings suggest a link between sensory-motor experiences, gestures and vocabulary acquisition. But how are these related? One hypothesis is that childrens manipulation of objects promotes their learning of concepts, these concepts then drive the use of iconic gestures rooted in actions with objects, as well as word learning. An alternative hypothesis is that iconic gestures scaffold vocabulary learning because gestures maintain important iconic similarity with the corresponding affordances and actions, while having communicative functions like words: thus emergence of gestures would be precursor to word learning. To-date, correlational data seems to support the first hypothesis, but existing data does not allow to clearly establish the direction of effects. The FORGE project aims to test between these hypotheses, to understand how learning new concepts (mental representations for new manipulatable objects), learning to gesture about these new tools and learning their labels are related to one another. The project uses a multi-disciplinary approach, bringing together traditional video-coding techniques from developmental psychology and psycholinguistics, and new bio-engineering sensor technology for movement analysis. As pre-school children learn new words on a daily basis, and because vocabulary is a strong predictor of academic achievement, establishing optimal conditions for learning to occur is critical to any educational setting. It is further critical to implement programmes assisting children with clinical impairments.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195891;660116;IntestineUb;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of Ubiquitin System on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells;1/01/2016;31/12/2017;;"The epithelium of small intestine has a higher self-renewal rate than any other mammalian tissues. This is fuelled by the intestinal stem cells which reside near the bottom of crypt. Tight regulation of the adult stem cell number is required to sustain an adequately sized population for optimal tissue homeostasis. Mis-regulation of homeostasis results in either hyperplasia or loss of stem cells. Although transcriptional regulation of stem cell homeostasis regarding multipotency and differentiation has been extensively studied, only little is known about post-translational modifications. A key mechanism of post-translational modification is ubiquitination by the ubiquitin system (US).

The in vitro primary intestinal organoid culture system recapitulates in vivo epithelium organization, is amenable to essentially all experimental technologies that have been developed for cell lines, and therefore serves as a novel, robust and powerful model system. Taking advantage of the intestinal organoids, this project is aimed to investigate the role of US on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells by: 1. Screening of US required for stem cell number regulation by CRISPR/Cas9 technology; 2. Characterization of the expression pattern and sub-cellular localization of candidate US; 3. Examining the effect of candidate US in signalling pathways involved in the homeostatic control by reporter assay and target gene expression; 4. Identifying target proteins of candidate US using surface proteome analysis, IP-mass, BioID or in vitro ubiquitination of arrayed proteins; 5. Performing biochemical and cell biological analysis of candidate US with its identified target proteins and signalling pathway components in vitro; 6. Generation of conditional knockout mouse models to elucidate the function of candidate US in vivo; 7. Conducting a small molecule screening for inhibitors that attenuate hyperplasia phenotype caused by E3 ligases mutation.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195962;660528;distraction;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Distraction as a Philosophical Concept and a Stylistic Device in France and Italy.17th-19th Centuries;1/09/2015;31/08/2017;;The proposed research challenges and reassesses the historical development of distraction in its philosophical and literary implications. The dominant Augustinian-Pascalian strain of Western thought has traditionally viewed distraction as an expression of human imperfection, which has therefore to be corrected in favour of concentration and logical thinking. My project reconstructs how the 17th and 18th cs. witness a different understanding of distraction in both the ethical and the aesthetic-cognitive spheres, paving the way to its revaluation as a productive resource, in literary and stylistic terms, between the 18th and 19th cs. By focusing on the French and Italian linguistic and cultural domains, characterised by a lively circulation of texts and by a relatively homogeneous cultural background, the Fellow will show how the genealogy of distraction intersects and mirrors the intellectual and cultural tensions between the Old Regime and the post-revolutionary decades. In particular, the proposed research will address the ways distraction tackles and reassesses the conflictual relationship between truth and falsehood, objectivity and subjectivity, theory and fiction, thereby blurring the borders between philosophical-theoretical and literary-fictional forms of writing. The project possesses both historical and theoretical implications. On the one hand, it reconstructs a fluid moment in Western cultural history, witnessing a profound reconfiguration of philosophical and rhetorical praxes, whose outcome may even be identified in literature as an attempt to recompose the original fracture between poetry and philosophy in which Western culture according to Agamben is rooted. On the other, it firmly relies on a strong philosophical framework that, through a constant dialogue with thinkers such as Bergson, Benjamin, and Rancire, understands distraction as a peculiar and intrinsic feature of intellectual modernity.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195976;660608;WATER INCENT;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Economic Instruments for Sustainable Water Management in Water Scarce and Drought Prone Irrigated Areas;1/06/2015;31/05/2017;;More than 50% of total water abstractions in Southern Europe come from the agricultural sector, rising to more than 80% in some regions. Water abstractions are particularly high and fast growing in profitable irrigated areas in the Mediterranean Basin, where agricultural demand enters in direct competition with basic environmental services increasingly often. Urgent action is needed to address this unsustainable trade-off. Economic instruments represent a means of adapting demand to collectively agreed goals and thus relief pressure over stressed EU water bodies. In particular, recent water resources research has put forward the role that can be played by agricultural water markets and drought insurance for irrigated agriculture. These two instruments have been already tested (markets) or at least explored (insurance) in a EU context, but it is still unclear what can be expected from them. The objective of my research is advancing in the design and development of agricultural water markets and insurance systems that contribute to the implementation of an effective and efficient water policy mix in the EU. In a first stage I will develop quantitative methods using Revealed Preferences Models and Agent Based Models to estimate the economic and environmental outcomes of the proposed instruments under different scenarios. In the second stage I will use an analytical framework to critically assess the efficiency and effectiveness of drought insurance and water markets in a wider policy context. Theoretical constructions will be illustrated with empirical applications in the Po River Basin District (RBD) in Italy and the Segura RBD in Spain.;168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDAZIONE ENI ENRICO MATTEI;IT;;; 195852;659842;ZPVMH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Synaptic integration in the ventromedial hypothalamic nucleus in aggressive behaviour;1/06/2015;31/05/2017;;Generating appropriate behavioural responses to sensory cues is crucial to ensure the survival of species, and relies on synaptic integration the process by which individual neurons convert synaptic input into action potential output. How the brain performs the computations that produce specific behaviours is an essential question in Neuroscience and has direct relevance to human health and well-being. The aim of this project is to determine mechanisms of synaptic integration in a circuit underlying aggressive behaviour in the mouse, and analyse how single neurons in the ventromedial hypothalamic nucleus (VMH) contribute to computations leading to aggressive behaviour. By combining behavioural, genetic, electrophysiological and optical techniques, this project will determine: (i) the biophysical properties and local connectivity of VMH neurons, (ii) the anatomical localization of synaptic inputs along their dendritic tree, and (iii) how VMH neurons that drive aggressive behaviour integrate synaptic input from anatomically and molecularly-defined pathways. Recent in vitro studies have uncovered a previously unknown degree of complexity of information processing that single neurons can perform. While a lot of these studies combining electrophysiological, optical and computational approaches have focused on cortical circuits important for learned behaviours, innate behaviours have not benefited from such experimental and analysis framework. This project will become the first to implement such multidisciplinary approach to determine the mechanisms of synaptic integration in the hypothalamus. The results of this study will provide mechanisms of how VMH neurons generate patterns of activity that lead to aggression, which will advance our understanding of information processing in fundamental innate circuits and contribute to development of solutions for control of aggressive behaviour.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 195745;659265;LEACON;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;LEArning-CONtrol tight interaction: a novel approach to robust execution of mobile manipulation tasks;7/03/2016;6/03/2018;;"One of the main challenges of roboticists is to take robots out of the factories and let them enter into unstructured environments, such as houses, hospitals, small manufacturers and dangerous area.
The objective of the project is to take a step towards the presence of robots in such environments.
Currently, there are still important obstacles to the massive diffusion of advanced mobile manipulation systems in the fields described above. First of all, programming mobile manipulators with the classical methods is still too expensive and time-consuming due to intrinsic complexity of mobile manipulation tasks.
A second limitation is that planning the robot motion completely off-line, as often happens in classical industrial applications, may likely bring to a failure of the assigned task, since a high degree of uncertainty is present and the environment can dynamically change. Such features may cause safety issues for humans potentially present in the workspace and for the external environment itself.
In order to tackle these limitations, the LEACON project has the objective to develop a framework that:
- allows robots to learn in a real world scenario manipulation skills from human demonstration
-exploits multimodal perception (tactile, proximity, visual, force sensors) to increase the robustness to unforeseen events and safety when manipulation tasks are executed.
To fulfill such objectives, a multidisciplinary approach that combines machine learning and perception-based control is proposed. The core of the proposed framework will provide two planning levels tightly connected: the high-level and low-level cognitive system.
To show the effectiveness of the developed architecture, the main use cases will be constituted by a robot that performs picking, manipulation, and placing operations in a dynamic, unstructured environment in presence of humans in its workspace. At the end of the project, the developed software will be released as open source code.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET MUENCHEN;DE;;; 195934;660375;PopMet;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating bacterial strain evolution through metagenomic genome assemblies;1/03/2015;28/02/2017;;"Recent advances in metagenomics have revealed considerable genetic variation among the microbes that populate the human gut. It has been shown that multiple strains of a bacterial species can coexist in a microbial community. However, accurately differentiating strains in metagenomic samples is mostly not possible, even though pathogenicity is usually strain specific.
Therefore, I propose to utilize single nucleotide variants (SNVs) to (i) identify and delineate bacterial strains and to (ii) reconstruct single strain genomes. As more than 1,000 metagenomic samples are available, a large database of bacterial genomes from natural environments will be built and made publicly available. This will give the opportunity to investigate the role of adaptive evolution, mutation rate variation between hosts and the colonization history of bacterial strains among humans, all with high confidence due to the sheer data volume. Further, I plan to explore rare SNVs (nucleotide variants segregating at very low frequencies) that many population genetic methods are reliant on. This will be of particular significance, as it will provide insights into growth dynamics of bacterial communities in natural environments, benefiting both evolutionary and clinical research.
Thus, the PopMet project is the application of POPulation genetic analysis on large METagenomic datasets.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;;; 196007;660935;BACTOSHAPE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Single cell biophysics of bacterial cell shape;1/04/2015;31/03/2017;;"In bacteria, the rigid external cell wall (CW) and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. Synthesis and chemical composition of the CW, a three dimensional polymer network that is one of the most prominent targets for antibiotics, are well understood. However, despite decades of study, little is known about the complex CW ultrastructure and the molecular mechanisms that control cell shape in time and space. MreB homologues assemble into dynamic membrane-associated structures thought to control shape by serving as organizers for the movement and assembly of macromolecular machineries responsible for CW biogenesis. However, the mechanistic details used by the MreB cytoskeleton to fulfill this role remain to be elucidated.
We will combine powerful genetic tools available in the model Gram-positive bacterium Bacillus subtilis with modern high-resolution fluorescence microscopy techniques and atomic force microscopy (AFM) to study the role of the MreB cytoskeleton and CW synthesis proteins in cell shape determination and maintenance. Additionally, the role of mechanical forces in the control of CW organization will be evaluated.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;;; 195896;660143;CHAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The transnational mobility of cheap print: British chapbooks in Italy, 1800-1850;1/09/2015;31/08/2017;;This action proposes mobility for an Italian researcher living in Britain to work in Ireland on a transnational historico-literary project. Her research focuses on the cross-cultural transfer of cheap print between Britain and Italy in the first half of the nineteenth century. The project advances existing knowledge of popular publishing and reading in two ways. Firstly, it contributes to the European historiography of cheap publications by extending the investigation of their production, distribution and reception to the Italian context. Secondly, and most importantly, it provides a concrete idea of the cross-cultural nature of cheap literature by exploring the mechanisms which regulate its migration from one linguistic and cultural realm to another. The transnational trajectory of cheap print is investigated with a focus on translation and on its potential to establish fruitful negotiations between the literary and cultural repertoires of the source and the target context. The project examines a corpus of chapbooks translated from English into Italian published between 1800 and 1850. The Italian chapbooks and their sources are analysed using an interdisciplinary approach which integrates theories of textuality, the history of the book and of reading, and translation studies. The comparative approach followed in my study will significantly enhance our understanding of popular literature and of the processes which led to the formation of a shared European heritage of popular culture. The multidisciplinary research environment at NUIG provides the ideal conditions for the researcher to develop this project and the skills necessary for her future academic career. The collaboration of Dr Niall Ciosin and the training that she will undertake in the history of the book will be particularly important to integrate her familiarity with translation and the eighteenth- and nineteenth-century Italian cultural context with new knowledge of popular publishing and reading.;175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;;; 195909;660205;ISPADMEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Integrin specificity in rigidity sensitive proliferation, activation and directional migration of endothelial cells;1/09/2015;31/08/2017;;"Cells have the extraordinary ability to regulate their morphology, functions and fate to minimal changes in the extracelullar microenvironment. Through multi-protein, cell-matrix adhesions they are able to recognize and respond not only to the chemical diversity of the extracellular matrix (ECM), but also to its physical and topographical features. Mechanical and structural cues encoded in the ECM have an essential role in healthy tissue function where contractility, spreading and proliferation are intricately regulated by cell-cell and cell-matrix adhesion and tension. Unsurprisingly, abnormal ECM mechanics are directly associated with disease and tissue malformation (atherosclerosis, wound healing and tumor formation). Understanding the mechanisms cells use to sense and transduce mechanical signals, as well as the contribution of key players in the process is a pressing, unmet challenge.
To achieve this goal, I here propose the development of an in vitro strategy that allows precise regulation of both biochemical and mechanical parameters in order to isolate their contribution on fundamental endothelial cell (EC) functions. The proposed work will exploit advances in materials science and nanotechnology to modulate with high precision the presentation of highly selective integrin ligands at the nanometer and micrometer length scales, on substrates with tunable viscoelasticity and mechanics. The anticipated effects of integrin engagement and substrate mechanics on ECs will shed light on how the microenvironment affects their proliferation, activation and directional migration, and help correlate these finding with pathological scenarios where blood vessel mechanics and EC integrin expression are deregulated. In summary, the proposed interdisciplinary approach will contribute both advanced tools to study cells in vitro and crucial answers for specific questions relating to EC biology.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195959;660521;QuantumPhotosynth;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum coherence in photosynthesis: towards single-molecule light-conversion devices;1/10/2015;30/09/2017;;Photosynthesis performed by plants, algae and photosynthetic bacteria is the biological process that transforms solar energy into chemical energy with high quantum efficiency. A complete understanding of the factors that modulate the efficiency of this process is a challenge centered at the nexus of fundamental physics and biology, and obtaining that knowledge could pave the way for the design of the next generation of cheap and highly-efficient light-conversion devices. The main aim of this project is to understand how quantum coherence modulates the efficiency of photosynthesis. Quantum coherence is likely to be involved in not only the first ultrafast stages of excitation energy transfer in the photosynthetic light harvesting antenna but also in the charge separation process in the photosynthetic reaction center by coupling to specific vibrational states of this pigment-protein complex (Romero et al, Nature Physics 10, 676-682, 2014) . Here we propose to use time-resolved coherent anti-Stokes Raman spectroscopy and two-dimensional photon echo spectroscopy to demonstrate the specific vibrational modes that sustain quantum coherence at the single molecule level. Time-resolved anti-Stokes Raman spectroscopy will provide an insight into the specific vibrations in the molecule that lead to sustained quantum coherence in the charge separation steps of photosynthesis. Results will be confirmed using two-dimensional photon echo spectroscopy and rationalized in a Redfield theory framework. To assess the role of energetic disorder, reaction centers will also be characterized using a combination of single-molecule techniques in order to correlate the quantum coherence arising at the single-molecule level with the efficiency of the whole ensemble. To achieve this, a new technique capable of quantifying quantum coherence at the nanoscale will be developed. This new technique and its applications will deeply impact quantum biology and other fields.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VU;NL;;; 195868;659985;STABLE_FABRY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Calibration of Astronomical Spectrographs with Stabilized Fabry-Perot Etalons;15/04/2016;14/04/2018;;"The holy grail of exoplanet research today is the detection of an Earth-like planet in the habitable zone of a Sun-like star. Doppler spectroscopy is an indispensable tool for finding and characterizing extrasolar planets; however, detecting an Earth twin by measuring the radial velocity (RV) perturbation it imposes on the parent star requires nearly one order of magnitude better RV precision than the best current spectrographs provide. A key component in addressing the limitations of existing instruments is the development of extremely precise calibration light sources that can be used to track drifts and imperfections of the spectrograph, removing them from the science data. A stable, reliable, and relatively inexpensive calibrator solves a chicken and egg problem in the field motivating the building of more stable spectrographs, secure in the knowledge that they will be able to perform to their potential. Project STABLE_FABRY consists of developing a novel calibration technique that can be applied to a wide range of high resolution spectrographs. This technique uses a broadband Fabry-Perot etalon to provide the calibration spectrum; the etalon is stabilized by referencing it to an atomic transition using standard laser spectroscopy methods. Our preliminary work already indicates that a stability of 3 cm/s can be reached with this method, making it precise enough for detection of Earth-like planets. The only other currently available calibration technology with demonstrated precision at that level is the laser frequency comb, which is an order of magnitude more complex and significantly more expensive. Our technique can easily be adapted to different echelle spectrographs in the visible and near infrared by simply using an etalon optimized for that particular spectrograph. Developing this concept into an observatory-ready system will present a major breakthrough for high precision spectrographs, enabling detections of Earth twins with Doppler spectroscopy.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG;DE;;; 196073;661247;FOLDASYNBIO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bioinspired Nanostructures by Self-assembly of Amphiphilic Non-peptide Helical Foldamers in Aqueous Environment;1/09/2015;31/08/2017;;The design and precise construction of biomimetic self-assembling systems in aqueous solution is a challenging yet potentially highly rewarding endeavor, contributing to the development of new biomaterials, catalysts, drug-delivery systems and tools for the manipulation of biological processes. A high level of sophistication with control over morphologies and functions has been achieved by engineering self-assembling peptide-based building units. Although peptides possess a number of specific advantages including synthetic availability, modularity, one difficulty resides in precisely controlling the rules relating primary sequence and secondary structure. Alternatively, opportunities exist to develop bottom-up approaches using non-natural oligomers also referred to as foldamers, with predictable and well-defined folding patterns. Advances in foldamer chemistry bode well for their use as building units for the precise construction of nanometer scale assemblies and for possible applications. This project will move a step forward towards the realization of this mission, by developing protein-like quaternary arrangements under sequence based control using amphiphilic helical foldamers in aqueous conditions. The applicant has been trained in the synthesis of folded oligoamides and more importantly has acquired a high level of expertise in the design and structural characterization of peptide-based assemblies. He will join and bring his expertise to a host laboratory in France that has pioneered the development of urea-based helical foldamers. Secondment in one established European group with prominent expertise in X-ray crystallography techniques and biological structure determination will provide the appropriate combination of knowledge required for this multidisciplinary study. This approach will be a milestone in the design of foldamer-based quaternary architectures and may lead to new functional nanostructures.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit de Bordeaux;FR;;; 195845;659773;SeisMo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;SEismology of the MOon;1/02/2016;31/01/2018;;"As part of the Apollo lunar missions, four seismometers were deployed on the near-side of the Moon between 1969 and 1972, and operated continuously until 1977. There are many difficulties associated with determining lunar structure from these records. As a result, many properties of the moon, such as the thickness, density and porosity of the crust are poorly constrained. This hampers our ability to determine the structure, geochemical composition of the moon, its evolution, and ultimately the evolution of the solar system. This proposal uses modern seismic processing techniques to overcome these limitations. Using ambient noise tomography, it will provide a new, more accurate, model of the lunar crust and mantle. I will apply recent advances in the full waveform modelling of scattering at planetary scale by the host institution to the strongly scattering lunar crust. We will explore entirely new routes for planetary seismology by investigating single-station inverse problems building on recent work in rotational seismology pioneered at the host institution. The project is designed to develop a profile for myself as a planetary seismologist, and to position myself and the host institution to work on the Mars InSight mission in the future. InSight is a NASA Discovery mission, scheduled to land in September 2016, which will deploy a single seismometer on the surface of Mars. We combine the expertise of the researcher in surface wave analysis and tomographic modelling; the facilities and expertise of Ludwig Maximilian University (LMU) in ambient noise studies, full waveform modelling, modelling of seismic scatter and rotational seismology; and an interdisciplinary team of researchers with experience of the techniques and with diverse interests in geochemistry, geodynamics and planetary evolution.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195937;660389;FeedbackTeamContest;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;FEEDBACK IN TEAM COMPETITIONS;1/04/2015;31/03/2017;;Although the effect of feedback on performance in individual competitions is analyzed both theoretically and experimentally, there are only few studies analyzing the effect of feedback on team performance in team competitions. The purpose of this research project is to understand the role of feedback in team competitions in various environments. There will be two parts in the project. In the first part, the effect of feedback on performance in individual and team competitions will be compared (both endogenously and exogenously formed teams will be considered). In this part, there will be just one task and team performance will be the sum of team members efforts. In the second part of the project, the effect of feedback will be analyzed in an environment where two complementary tasks will be assigned to team members. In this case, the amount of complementarity will be the free parameter and how agents choose their teammates (endogenously or exogenously) will be varied. Both projects will be experimental studies. In addition to the significant contribution to the literature, the project plans to contribute to workplace-innovation policy of Europe, which aims at improving staff motivation, thereby enhancing labor productivity, organizational performance, innovation capability, and consequently business competitiveness. The project will contribute to this objective by finding out the most stimulating tournament environment for workers.;157845,6;157845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MIDDLE EAST TECHNICAL UNIVERSITY;TR;;; 195901;660155;SchmaVirusVacDiag;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Novel vaccine and diagnostic strategies against Schmallenberg virus;15/06/2015;14/06/2017;;"Schmallenberg virus (SV) is a pathogen that has been discovered in European livestock 3 years ago. Since then, it has been found that this virus is associated with disease in sheep, goats and cattle across Europe . In livestock, the symptoms associated with the disease include stillbirths and malformations in newborn animals. The presence of the virus in Spain, France, Germany, Italy, the UK, the Netherlands as well as Russia, has shown that this disease is a fast spreading threat to the European livestock industry, and has the potential to cause significant economic impact across the continent. Furthermore, due to high volumes in international trade of livestock, the potential of this disease to spread beyond Europe poses another potential threat to the industry. Recent work using a related bunyavirus (Rift Valley Fever virus) has found that effective DNA vaccines can be generated . These vaccines have the advantage of being administered easily, having low-manufacturing costs, and providing long-lasting efficacy-making it ideal for large-scale vaccination campaigns. Furthermore, studies on related viruses have shown that monoclonal antibodies can be generated for use in diagnostic testing. Using these concepts, we propose to extend this principle to Schmallenberg virus, in order to: i) develop an easy-to-use diagnostic test for Schmallenberg detection; and ii) develop a DNA vaccination strategy that could be used to limit further future outbreaks.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS;ES;;; 195876;660031;MEMOTION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Changing the course of cognitive decline in normal aging with positive emotions by training brain plasticity;1/09/2016;31/08/2018;;Aging is a primary health concern for all European countries and the entire world. Healthy adults experience memory declines that affect daily functioning, yet their ability to process emotion is well-preserved. The benefit of utilizing older adults spared emotional abilities to help mitigate memory declines has not been previously explored and will have substantial implications for daily life. The current project has two main goals. First, we will employ cutting-edge functional imaging technology to investigate age-related neural interactions between emotion and memory. To this end, electroencephalography (EEG) will record electrical brain activity non-invasively while participants perform an innovative memory task with an emotional component. Second, we will implement an innovative memory training programme to test brain plasticity, with a focus on transferring these benefits to daily life. It will enhance the importance of age-related preserved emotions to improve memory deficits. EEG activity will be recorded before and after training to examine the neural changes as a result of training. Besides the extensive research experience of the applicant in fundamental research of aging, the novel approach will be to conduct this project by synergizing key aspects of fundamental and applied sciences, emphasizing transfer of knowledge and collaboration with industry. There is a clear benefit of the mobility for both the applicant and the host, ensuring high quality results and dissemination. In this regard, the host will ensure the acquisition of new technical, management, tutorial and transferable skills. The applicant will also benefit from a multidisciplinary environment enhancing international collaboration that will surely contribute to diversify her career. Finally, via a specialized Career Development Plan, the host will provide the ideal training and validation environment, through which the applicant will reach unprecedented levels of professional maturity;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD AUTONOMA DE MADRID;ES;;; 195947;660440;MIRAGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;MicroRNAs as therapeutic targets for ARVC.;1/08/2015;31/07/2017;;ARVC is a hereditary disease mainly characterised by the progressive substitution of the myocardium with fatty or fibro-fatty tissue involving predominantly the right ventricle. Clinically, ARVC shows wide variation between individuals. Together with modifier genes, common sequence variants, and environmental as well as endogenous factors, epigenetic modifiers such as miRNAs are hypothesized to be potential targets for disadvantageous environmental stimuli and may lead to the onset of complex and heterogeneous diseases such as ARVC. The main research objective of this EF is to assess and validate the relevance of disease mechanisms underlying the development of ARVC and to identify novel RNA-based targets in mouse models and ARVC patients. The EF programme comprises two tightly linked components research and complementary training - that will be complemented with secondments in two (non-) academic organisations active in the field of molecular cardiology. The host organisations are strongly committed to enhancing the creative and innovative potential of the ER who wishes to diversify her individual competence in terms of skill acquisition to become a successful European scientist.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT MAASTRICHT;NL;;; 195837;659715;VascColl;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Temporally controlled delivery of vascular therapeutics from a regenerative template for diabetic wound healing;1/05/2015;30/04/2017;;"Having recently returned to the EU following Graduate (Massachusetts Institute of Technology) and Postdoctoral Training (Harvard University) in the USA, I hope to work as a MSCA Reintegration Fellow to tackle a devastating element of the escalating epidemic of diabetes. Specifically, the lack of synchronicity in diabetic wound-healing can lead to chronic diabetic foot ulcers (DFUs), with limb amputation being the devastating consequence in many cases. Thus, the scientific goal of this proposal is to integrate my tools for temporally-controlled drug delivery with the existing collagen-based scaffold developed in Prof. Fergal OBriens group at the Royal College of Surgeons in Ireland (RCSI). The proposed novel scaffold will be used to deliver vascular bioagents to DFUs, with ultrasound used as a trigger to delay the delivery of a vascular maturation bioagent. The target is to improve healing by stimulating vascularisation. The additional positive effects the bioagents may have on macrophage polarisation will be explored during a planned secondment.
The training objective of this grant is to attain the requisite scientific and complementary skills so that I am fully prepared to run a research lab and teach in a top academic institution. This will be achieved through the expert supervision and input of Prof. OBrien and during a planned secondment and will be backed up by colleagues in the lab and RCSIs staff training activities. In addition, by managing the project, I will further develop skills relating to project planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also continue to avail of opportunities to teach and to recruit and supervise students on this project or related works.
If successful, this grant will help me establish an independent research niche in active and emerging research fields, while equipping me with the requisite skillsets to successfully work as an independent faculty member.";187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;ROYAL COLLEGE OF SURGEONS IN IRELAND;IE;;; 195730;659151;QEAH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum Entanglement And Holography;1/09/2015;31/08/2017;;"Entanglement Entropy and other measures of quantum entanglement have recently given great insights into the physics of both quantum field theories and gravity.
In the context of quantum field theories, entanglement entropy emerged as a useful measure of degrees of freedom whereas in gravity it proved as an indispensable tool to constrain gravitational entropy (e.g. Bekenstein Bound, Covariant Entropy bound).

For these and other recent achievements, embedding entanglement in holography was crucial because the holographic principle, and its precise realization, the AdS/CFT correspondence, allow one to learn about gravity using quantum field theory and vice-versa.

The objective of the current proposal is to investigate and highlight quantum aspects of the AdS/CFT correspondence (such as the emergence of space-time and gravity) by relating entanglement in integrable models to entanglement in quantum field theory and gravity.

The arena for the study will mainly be N=4 Super-Yang-Mills (SYM); a super-conformal theory, integrable in the planar limit. The study however will have greater applicability since many non-integrable theories contain integrable sectors.

Among questions to be addressed are:
What does entanglement entropy of the spin chain computes in the dual CFT?
What does it correspond to in gravity?

The proposed plan will add significant developments to the rapidly growing field of research on entanglement in holography. On the quantum field theory side, the current proposal will deepen understanding of the quantum dynamics at both weak and strong coupling. Via holography the information obtained will provide further insights on aspects of black hole physics.";187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;IE;;; 195919;660259;OPTOFRAX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Optopharmacological brain mapping of autism mouse models;1/07/2015;30/06/2017;;Manipulation of neurons with light-regulated proteins and drugs has opened unprecedented possibilities for phototherapies for neurological diseases. The host laboratory has developed a powerful new optopharmacological tool: a selective photoswitchable modulator of metabotropic glutamate receptors (mGluR). This drug can be activated or inactivated with light so that its action can be finely patterned in space and time. We aim at developing a novel application for this optical tool: a brain functional mapping technique. We will test it at two different levels of resolution. First, we will map the therapeutic site of action at whole-brain level. Inhibition of mGluR is a promising therapeutic strategy for autism disorders, including Fragile X, but the brain region responsible for this effect is not known. We will inactivate the drug locally by illuminating specific regions of the brain and will identify which region is the target for the therapeutic effect. Second, we will map the physiological contribution of mGluR to neuronal plasticity at the minimal spatial resolution: the individual synapse. Activation of mGluR induces long-term synaptic depression at the level of neurons, but it is unknown if it is also true at the level of single synapses. We will inactivate the drug in a single synapse using laser light and will test whether this specific synapse undergoes structural depression. This project will prove the utility of optopharmacological tools to map the therapeutic and phyisological mGluR function. This original approach could open countless possibilities for scientific, medical, and commercial applications. The project is an excellent opportunity for the Researcher to further develop his knowledge and to position him in unique multidisciplinary environment that will foster his career progression towards independence. At the same time, the Researchers experience acquired at MIT will be extremely valuable for the host institution and the European Research Area.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA;ES;;; 195960;660523;NoBios;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;No Biofouling Surfaces;1/04/2015;31/03/2017;;Biofilms consist of bacteria, proteins and cells which attached to a solid surface. Prevention of biofilms is of extreme relevance in industry and science as they are ubiquitous and able to provoke corrosion or failure in pipelines, heat exchangers, biomedical devices, artificial implants or food processing facilities. Biofilms are often battled with antibiotics, but bacterial resistance is a major problem. Therefore, novel approaches are required to avoid biofouling. We will explore the application of (1) superamphiphobic coatings, (2) slippery liquid infused porous surfaces and (3) functional pillar arrays surfaces to battle biofouling. These surfaces have in common that they strongly repel water, blood and organic liquids, and even soap-water mixtures due to a synergy between rough topography and a special chemistry. We will monitor and characterize the adhesion of bacteria, proteins and cells to these surfaces depended on shape, size and chemical of composition of the surface and the liquids. Several classical and highly advanced cutting edge methods will be used to investigate the wetting and fouling properties of these surfaces, especially laser scanning confocal microscopy. In the final steps of the research, we will evaluate the robustness of the surfaces and the biocompatibility in order to establish potential real applications in collaboration with industrial partners. We exert a high impact of this fellowship to the scientific community and the rest of society.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195853;659847;IsoBar;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Relative Role of Reproductive Isolating Barriers During Speciation;11/03/2016;10/03/2018;;"Understanding the appearance of reproductive isolation is essential for understanding mechanisms underlying the origin of species. This project aims at understanding the relative importance of different isolating barriers during adaptive speciation by looking at patterns of genomic divergence. I will use numerical modelling, analysis of RNAseq data from several biotypes (incipient species) of a model organism (pea aphid), and will perform mating experiments to address four research questions:
(1) Which patterns of genomic divergence arise when different isolation barriers apply?
(2) Which patterns of genomic divergence do pea aphids show?
(3) Do pea aphids biotypes have behavioural mate choice?
(4) Which reproductive barriers are needed for the completion of speciation in hybridizing biotypes?
Successful implementation of this project will improve my career perspectives, because it's training objectives were chosen to guarantee addressing skills gaps, diversifying experience and strengthening existing skills. European Research and Society will also benefit from results of this project, both though academic and economic pathways.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195922;660281;TransHI-Rom;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Risk and MigrationA Transnational History of Romanian Migration to Western Europe (2002-2013);1/09/2015;31/08/2017;;The liberalization of border controls following the breakdown of the Europe's communist regimes led to important flows of East-West migration. Western Europeans, fearing a literal invasion of Central and Eastern European immigrants, increasingly interpreted this new-found mobility as being fraught with risk. This research project will examine the history of Romanian migration to France and Italy from 2002 until the end of 2013 from the perspective of risk. It will analyse how evaluations of and responses to risk shape the migration process. The first step of this project will be to understand how fear of migration influences political responses and regulatory measures. The second step will investigate how this sense of fear developed and evolved within French, Italian and Romanian societies. It will also analyse how risk perception impacts migrants relationships with the host society. Focussing on the migrants own perceptions of their mobility, the third step of the project will examine how they respond to risk. An emphasis will be placed on young adults. The inter-disciplinary perspective adopted in this study will provide a more complete history of Romanian migration during the last decade. Drawing on empirical research, this study will focus on the connections that could be established between European citizens. The final objective is to demonstrate the relevance of risk in understanding the migration process.;168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI PADOVA;IT;;; 195894;660128;SAC_EarlyEmbryo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;SAC robustness in the transition from meiosis to mitosis;1/02/2016;31/01/2018;;"Meiotic divisions in the oocyte have been shown to be surprisingly error-prone compared to the reliable chromosome segregation that takes place in dividing somatic cells. The high frequency of chromosomal abnormalities found in pre-implantation embryos in mammals coupled with the fact that the first divisions of the embryo resembles meiosis in several aspects suggests that the mechanisms controlling chromosome segregation, most importantly the spindle assembly checkpoint (SAC), only become fully operational after the transition from meiosis to mitosis during early development.
Despite the importance for early embryonic development, the sensitivity of mammalian embryos to light and the absence of a functional reporter of the SAC in mice have precluded real-time imaging of chromosome segregation and its control in the first embryonic divisions. Recent advances in light sheet microscopy in the Ellenberg lab now allow me to study chromosome segregation. In addition, in collaboration with the EMBL Transgenic Facility I will be able to rapidly generate the first SAC reporter mice that will permit me to test the checkpoint functionality up to the blastocyst stage.
Taking advantage of this unique opportunity to combine new technology with a novel reporter animal model, I plan to study how the SAC changes from meiosis to the first embryonic divisions of blastocysts. To this end, I will analyze SAC signalling and dynamics and assess whether the robustness of the SAC increases with development. My project aims to improve our understanding of chromosome segregation during mammalian pre-implantation development, and therefore the results of my research will be important to shed light on the molecular causes of aneuploidy in the early embryo, fundamental for our understanding of infertility and to improve the process of in vitro fertilization.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;;; 195830;659669;EPIRIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;EPIGENETIC REGULATION OF INFLAMMATION IN NAFLD;1/05/2015;30/04/2017;;Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing clinical problem, affecting a third of the European population. The transition of hepatic fat accumulation to inflammation is the key event taking place in the progression of NAFLD. This is controlled by a number of inflammatory and immune pathways including the activity of Natural Killer (NK) and Natural Killer T (NKT) cells. Progression from hepatic lipid deposition to inflammation and cirrhosis also follows a substantially variable course. It has been estimated that less than 10% of patients develop end-stage liver disease. Individual variability for disease progression is partly controlled by environmental factors and genetic background. However, it is not known how immune and inflammatory pathways are orchestrated by epigenetic mechanisms. The project hypothesises that NK and NKT cells are programmed into inflammatory state by epigenetic modifications in progression from fatty liver to inflammation. In this project, histone modifications and DNA methylation will be studied by genome-wide and loci-specific approaches in NK and NKT cells purified from animal models of NAFLD and a prospectively-designed human NAFLD cohort. Reversibility of these modifications will be investigated following the regression of liver disease in animal models and after the implementation of lifestyle changes in humans. Lastly, the therapeutic potential of targeting histone modifying enzymes by short hairpin RNA and small molecule inhibitors in NK and NKT cells for modulating inflammatory response will be investigated. The project will be the first comprehensive study investigating cross-talking epigenetic mechanisms in NK and NKT cells in NAFLD.;157845,6;157845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOC UNIVERSITY;TR;;; 195944;660411;LABVaccFish;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;USE OF LACTIC ACID BACTERIA AS DELIVERY VEHICLE FOR ORAL VACCINATION OF FISH;4/01/2016;3/01/2018;;"This project will provide a proof of principle that food-grade lactic acid bacteria (LAB) can be used as vehicle for oral vaccination of fish and will unravel the underlying mechanisms of memory formation in zebrafish. We will engineer Lactococcus lactis to deliver a DNA- or protein-based prototype vaccine against spring viraemia of carp virus (SVCV). The choice of virus and antigen is based on work showing that injection vaccination with DNA plasmids encoding the G protein of SVCV is highly successful. This vaccination route however, is less suitable for mass delivery and alternative strategies aiming at delivering the vaccine via the oral route are required. Food-grade lactic acid bacteria as vaccine vehicle are an attractive strategy to deliver vaccines at mucosal surfaces that has never been investigated in fish. We will use zebrafish as animal model to monitor real-time vaccine uptake and kinetics of immune responses. Already available knock-out and transgenic zebrafish lines expressing reporter genes under the control of cell- or cytokine-specific promotors will help dissect the contribution of innate and adaptive immune responses induced by vaccination. We will develop novel transgenic zebrafish lines for the controlled ablation of zebrafish cytotoxic T lymphocytes (CTL), to test the hypothesis that long term protective immunity to SVCV is mainly CTL-mediated. Altogether, this project will provide a proof of principle for the development of mucosal vaccines suitable for mass delivery in fish using commensal bacteria, supported by the unravelling of immune mechanisms important for memory formation using zebrafish as animal model. This project will familiarize the candidate with mucosal immunology using state-of-the-art techniques such as transgenesis and live microscopy in an animal model of high interest to the Life Sciences; this will promote his development as independent researcher and facilitate the acquisition of a stable research position in Europe.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195881;660060;BRIDGES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bioinformatic approaches to identify and detect both disease- and drug-related genomic alterations in breast cancer patients;1/06/2015;31/05/2017;;"Breast cancer is the most common cancer among European women showing high clinical and molecular heterogeneity. Current clinical management causes patients overtreatment with implications on both patients quality of life and healthcare costs. Moreover, intrinsic or acquired tumor resistance to treatment leads to incurable metastatic progression in a significant proportion of patients.
Advances in cancer genomics highlighted a high inter- and intra-tumor genetic heterogeneity, reinforcing the need for a mutation-based personalized treatment and a way to non-invasively monitor evolving disease. This project will significantly contribute in addressing such unmet challenge aiming 1) to identify altered breast cancer driver pathways, 2) to study their association with drug response and 3) to develop tools for a non-invasive assessment of such alterations.
By integrating multi-dimensional molecular data from more than 3000 cases, driver pathways will be identified and their association with previous breast cancer classifications as well as their prognostic significance will be studied. Their predictive power will be investigated in a matchless bio-bank of Patient Derived Xenografts, a much more reliable pre-clinical model, able to recapitulate inter- and intra-tumor heterogeneity observed in patients. Multi-dimensional molecular data and high throughput drug screenings are available and will be integrated to identify novel pharmacogenomics associations.
Mining of such amount of data will allow defining a portfolio of relevant breast cancer alterations that will be sought in plasma of patients from the DETECT trial, towards a non-invasive monitoring able to guide therapeutic strategy.
Development and application of cutting-edge computational approaches is fundamental to reach above aims and it will constitute a major part of the efforts, considerably expanding Experienced Researcher's know-how in the field of cancer genomics and translational medicine.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195932;660351;Emu Cam;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Engineered multi-scale carbon materials;1/08/2015;31/07/2017;;"Over the past years, industrial interest in carbon particles such as carbon nanotubes (CNTs) and graphene has resulted in low cost mass production of these materials at low cost. For commercialization purposes it was essential to integrate these new materials with existing high-throughput manufacturing methods such as injection moulding. Unfortunately, these processes result in un-organized CNT arrangements whose figures of merit typically drop by an order of magnitude compared to what is measured in individual nanoparticles.

Some of the most promising future applications of CNTs and graphene, such as high density energy storage and water filtration however require engineering of order, morphology, and porosity at several length scales to create highly ordered 3D structures. In this project, we propose a new process which assembles CNTs and/or graphene into microstructures using microfluidic emulsification followed by large area self-assembly into colloidal crystals. This approach provides a novel scalable route to sequentially engineer nano-, micro-, and macroscale material architecture. The ability to engineer multi-scale material structure will be harnessed to fabricate new high performance water filtration devices. Further, this project will impact other diffusion limited processes such as energy storage, catalysis, and photovoltaics.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195861;659927;SorCSbalance;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.;1/05/2015;30/04/2017;;"Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders. The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important. The host laboratory recently identified the sorting receptor SorCS1 as a key regulator of the synaptic abundance of glutamate receptors and adhesion molecules, including neurexins and neuroligins. SorCS1 has been associated with a variety of neural disorders, including autism, schizophrenia, and Alzheimers disease. I hypothesize that SorCS1 controls E/I balance in the brain by regulating the synaptic abundance of cell surface receptors. I shall test this hypothesis via the following specific aims:

Aim 1: To analyse whether SorCS1 regulates synaptic trafficking of adhesion molecules and neurotransmitter receptors under basal conditions and during synaptic activity.

Aim 2: To define how SorCS1 affects excitatory and inhibitory synapse function in vitro and in vivo.

Aim 3: To determine whether perturbed SorCS1 levels and disease-associated SorCS1 mutations affect E/I balance in neural circuits.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;VIB;BE;;; 195822;659644;SPERONI;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sperone Speroni (1500-1588) and the Rebirth of Sophistry in the Italian Renaissance;1/09/2015;31/08/2017;;This two-year research project aims to analyze the works of Sperone Speroni degli Alvarotti (Padua 15001588), his re-evaluation of ancient sophistic perspectives and his legacy in the early modern age. Speroni was one of the most important protagonists of the Renaissance debate on language and logic as well as civil and speculative philosophy. Educated as an Aristotelian, he eventually developed a distinctive philosophy and was the first to challenge Platos (327-447 BCE) condemnation of sophists. Despite the fact that Speroni was a central figure of Renaissance philosophy and literature in the vernacular, he is one of the most neglected authors in scholarly production. Furthermore, scholars have considered Speronis interest in ancient sophists as a marginal aspect of his philosophy and have disregarded the paramount role of the periods vernacular writing on sophistry that began with his works and spread throughout sixteenth-century Italy. This project will not only contribute to the research on vernacular Aristotelianism funded by an ERC Starting Grant 2013 (ARISTOTLE 335949) and led by Marco Sgarbi but also fill the gap in international studies with a complete analysis of the subject. Teodoro Katinis, an Experienced Researcher educated in European institutions and at Johns Hopkins University (U.S.A.), presents a research proposal from which the ground-breaking findings will revolutionize the traditional scholarly approach to a crucial period of the history of Western culture. Katinis expects that the development of this project will profoundly impact his career. Thanks to the training provided by Ca Foscari University in Venice and to its international network, Katinis will acquire new skills and build fruitful relations with European institutions and scholars. The training, network and publication of the projects outcomes will increase Katinis possibilities of obtaining an eventual ERC Grant.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA CA' FOSCARI VENEZIA;IT;;; 195993;660743;AdoDigitFamX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Adolescents, Parents and Digital Media: Looking for the pattern that dis/connects;1/09/2015;31/08/2017;;"This project will use a trans-disciplinary framework of social and developmental psychology and media and communications and the innovative methods of the First Person Perspective and Digital Ethnography to address existing gaps in research into the use of Information Communication Technologies, child development and family communication. Commenting upon research in the field, the recent report www.eukidsonline noted a prevalence of studies based on quantitative methods and a neglect of focus on mobile, convergent and emerging technologies. It also identified a persistent focus on risks and harm rather than opportunities and benefits and the lack of information on the role of adults, safety mediation and their effectiveness. This project fills these gaps by: (1) capturing the actual practices of adolescents with ICTs; (2) understanding how ICTs, family communication and parenting mutually shape one another; (3) exploring the opportunities and risks of ICTs for family and child development and the role of parents as safety mediators. A minimum of ten families with at least one adolescent child aged 13-16 will be recruited through Italian secondary schools to participate in the research which will involve data gathering via micro cameras (subcams) and video-interviews. Our innovative methods will provide new knowledge on: parents and adolescents individual and interpersonal practices in relation to ICTs; the goals, motives, representations and emotions underlying these practices and ICTs mediation processes in everyday family life. The implications of ICTs use for families and childrens health will also be considered. The results will be disseminated to socio-educational and clinical agencies, policy makers, and the general public. The fellowship will be hosted by the Department of Social Psychology at the London School of Economics and Political Science, a pioneer in Digital Ethnography and co-supervised by the Department of Media and Communications.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;UK;;; 195886;660081;MWGRAV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High Sensitivity Matter-Wave Gravitation Sensors;15/04/2016;14/04/2018;;"After more than 20 years of fundamental research, atom interferometers have reached sensitivity and accuracy levels competing with or beating inertial sensors based on different technologies. Atom interferometers offer interesting applications in geophysics, inertial sensing, metrology and tests of fundamental physics. Recently, a growing interest of the application of atom interferometry to gravitational wave detection and geophysics has been drawn. These applications beyond the pure scope of atomic physics require the development of more performant atomic inertial sensors, particularly for the use of matter-wave interferometers in gravitational wave detectors, where sensitivity levels far beyond the state of the art must be demonstrated. The proposed project aims at contributing filling this gap by studying new atom and optical interferometry techniques, in order to significantly improve the performances of matter -wave gravitation sensors.
The proposed MSC action will significantly impact the design of a new class of matter-wave gravitation sensors, which are under study in several countries in the world. In the excellence metrology environment of SYRTE, the MSC applicant will foster challenging developments in atom interferometers, with a high impact on the communities of atomic physics, geophysics and gravitational wave detection. On this path, the Experienced Researcher will benefit from an original and efficient training by the host group through knowledge transfer, acquisition of new scientific and management skills, enlargement of her professional network and development of her track record.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;OBSERVATOIRE DE PARIS;FR;;; 195715;659072;ResisGal;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ostreid herpesvirus 1: Genetic selection of Resistant strains and environmental interaction in the Atlantic coast of Spain (Galicia);1/09/2015;31/08/2017;;"One of the main concerns in the aquaculture sector is the significant mortality of the Pacific oyster, Crassostrea gigas, the principal shellfish cultivated worldwide. Among other factors, the presence of a virus has been directly associated with these mortality events which can largely exceed normal losses. The economic impact of the disease in oyster production has reached worrying levels since it has been spread to important producer countries in both hemispheres.
Bivalve disease control can be a challenge due to the lack of an acquired immune response and therefore the impossibility to treat them. Long term solutions such as selection of resistant strains have been referred to as a priority by the scientific community. Novel sequencing methodologies have increased the genetic information on this specie and the development of selective breeding programs is nowadays more achievable than ever before.
In this study, resistant strains will be genetically characterized and investigated in the field in order to identify the molecular markers required for assisted selection in future breeding programs.
The relationship between environmental parameters, virus transmission and virus prevalence will be further studied with the aim of describing an early detection method of oyster mortality.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 196058;661160;MetAccembly;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Accelerating metal-directed assembly, recognition and catalysis with computational methods;1/05/2015;30/04/2017;;Transition metals (TMs) are found in the core of several phenomena such as catalysis, self-assembly and (bio)molecular recognition and are directly involved in a number of diseases that span from cancer to neurodegenerative disorders. The presence of metal ions or metallocofactors in the active site of enzymes remarkably enhances the diversity of functions displayed by these biomolecules. TMs are also basic elements of approved drugs and MRI contrast agents playing a key role in biomolecular recognition. Metals in biology are extremely important but are also extremely complex to characterize and its role in processes such as protein assembly and molecular recognition is still poorly understood. These important biological processes take place in a broad range of time scales that span from ultrafast bond vibrations occurring in femtoseconds to slow conformational changes that require milliseconds to even seconds to be completed. The long-term goal of this project is to understand how and where these interactions occur. In the first goal of this proposal, we aim to develop a novel computational method (extended aMD) based on accelerated molecular dynamics that can be used to gain insights into metal-directed assembly, molecular recognition and biocatalysis at a reasonable computational cost. The second research goal of the proposal is to combine state of the art techniques of electronic structure with the new computational method to gain insight into the TMs-driven assembly, biomolecular recognition and catalysis mechanism of amyloid formation, inhibition and catalytic power. Extended aMD will be a versatile method that in principle will be applicable to describe assembly of large biomolecules. Applications in the field of enzyme design and drug discovery are expected in the long-term. After the execution of this project, the applicant will acquire a wider perspective on the field, as well as reached a position of full independence and professional maturity.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE GIRONA;ES;;; 195904;660171;EWatLHC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electro-Weak corrections at the LHC;1/10/2015;30/09/2017;;In view of the next run of the LHC, and of the impressive mole and quality of the collected data, accurate theoretical predictions will be mandatory in order to perform accurate measurements of the Standard Model parameters and to identify signals of the existence of new particles. If it is certainly true that impressive progresses have been achieved in the last years, in particular in the field of perturbative computations of cross sections and differential distributions, it is also true that much more has still to be done. The current proposal is focused on the computation of one class of corrections which affect LHC processes, the so-called NLO electro-weak correc- tions. This class of correction can have large impact in particular on events characterised by large energy scales, which will be more and more frequent at the next high-energy LHC run. Instead of proceeding on a process by process basis, the suggested path to follow is the one of automation, which has already proven successful in the case of NLO corrections originated by strong interactions. The automation of this class of corrections will allow to perform systematic studies about their effects on observables and processes relevant to the LHC.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195945;660417;BRACE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Breaking down arenavirus cell entry;1/10/2015;30/09/2017;;Hemorrhagic fever viruses are serious human threats for which we dont have adequate treatments available, which is painfully highlighted by the current Ebola virus outbreak in Western Africa. These viruses are obligatory intracellular parasites that make use of the host machinery at every phase of their infection cycle. Virus attachment and entry are the initial steps, which requires engagement of a viral glycoprotein with a cell surface receptor. This interaction then triggers internalization of the virus particle via a Trojan horse-like vesicular pathway, eventually resulting in the release of the viral genome into the cytoplasm of the target cell. We have recently shown that cell entry of at least some hemorrhagic fever viruses (i.e. Ebola virus and Lassa virus) is even more sophisticated, as it requires triggered-recognition of an intracellular receptor as an unexpected additional step. A precise understanding of how these major pathogens enter cells is required to reveal the mechanisms by which they cause disease. In this application, I will combine targeted engineering of viral systems with a genomics approach that enables crystal-clear, yeast-like genetics in human cells. Focusing on arenaviruses, these genome-wide surveys will reveal host factors indicative of virus entry tactics never observed before. I will use biochemistry, microscopy, and cell biological assays to examine in detail the virus-host interplay with these factors and will identify promising new antiviral targets for arenavirus family members that cause human disease. Overall, I foresee that this project will provide a much-needed window on the unique cell entry strategies of these lethal pathogens, which thus far revealed a surprising diversity in the biological host networks being hijacked to establish infection.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek ziekenhuis;NL;;; 195838;659722;PREDACTION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Prediction and Anticipation of Actions: Modelling How We Foresee the Others;1/02/2016;31/01/2018;;"The ability to understand and predict the actions of others is critical for human social interaction but how the brain accomplishes this function is still poorly understood. This project will explore this fundamental question using an original and innovative approach, by studying how we anticipate the actions of others before they even start to act. The final aim will be to develop a model that integrates different forms of information available before the action starts with kinematic features available once the action has started. To achieve this aim, we will use a combination of EEG/ERP and fMRI that will be integrated through the use of sophisticated source localization software and analysis to obtain a complete picture of when and where each mechanism becomes informative in the brain. This project will shed new light on the study of social cognition by unraveling little studied but crucial aspects of action understanding and prediction. In addition to opening new grounds in the field of social neuroscience and adding theoretical and methodological expertise to my skill-set, the findings and the resultant model of action prediction and social interaction will be useful also beyond social neuroscience. The project could contribute to technological development in the brain computer interface and social robotics fields (e.g. building robots able to smoother interactions), as well as be applied to the understanding of social deficits in psychiatric disorders (i.e. autism and schizophrenic patients). The Social Brain Lab at the Netherlands Institute for Neuroscience (NIN) represents the most suitable environment for this project by providing: world expert in the field of action observation with prominent expertise in the fMRI and EEG techniques (C.Keysers and V. Gazzola); all the technical facilities necessary for the success of the project; a world leading neuroscience community present at the NIN that will contribute to my further training and project development.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;NL;;; 195907;660191;ACM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cholesterol metabolism as a driver of prostate cancer aggressiveness;1/04/2015;31/03/2017;;"According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The current view of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolic reprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retain a differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts for recurrence and resistance to therapy. While we know more about the metabolism of tumor cells and its implication in cancer, our knowledge about the metabolism of cancer-initiating cells remains insufficient.
Obesity is associated with increased risk of prostate cancer metastasis and death. On other side, statins treatment reduces the risk of PCa, indicating that cholesterol might have a role in the onset of the disease. Overweight and obesity rates in EU affect 50 and 20% of the population respectively. Therefore, it is critical to define the role of environmental factors such as nutrition and lifestyle for cancer prevention.
Preliminary studies in our lab indicate that cancer initiating cells are highly enriched in cholesterol synthesis genes and their sphere formation capacity is dependent on cholesterol synthesis. We hypothesize that an active cholesterol metabolism is essential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells.
I will use a combined transcriptomic and metabolomic approach to define the alterations of cholesterol metabolism. I will study the mechanisms by which cholesterol metabolism regulates CIC function. I will study the feasibility of therapeutic targeting of cholesterol metabolism in prostate cancer using a well established mouse model. And finally, I will do a prospective associative study of statin treatment with CICs markers expression in patients.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS;ES;;; 195879;660047;PAnaMoL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Proof-theoretic Analysis of Modal Logics;1/05/2015;30/04/2017;;"The PAnaMoL project aims at systematising proof theory for modal logics. We intend to provide a unified perspective on sequent-style calculi and a deeper understanding of the general connections between axiom systems and sequent-style calculi for such logics. In detail the research objectives are:

- The systematic development of suitable syntactic characterisations of classes of modal axioms corresponding to natural formats of rules in different sequent-style frameworks (e.g. sequent, hypersequent, nested sequent or display calculi) including algorithmic translations from axioms to rules and back.

- A systematic comparison of the different sequent-style frameworks according to their expressive strength.

- The exploitation of these results in the investigation of: classification results stating necessary and sufficient proof-theoretic strength for important examples of logics such as GL and S5; uniform decidability and complexity results for large classes of logics; general consistency proofs.

The research conducted in the project will be of relevance to researchers in all fields where modal logics are used to model complex phenomena and provide easy-to-use results and methods for the proof-theoretic investigation and implementation of newly developed modal logics.";178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET WIEN;AT;;; 195815;659593;ProactionPerception;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;From oculomotor action to perception;1/04/2015;31/03/2017;;"The proposed scientific project addresses a gap in our current knowledge in neuroscience linking sensory physiology and motor behavior to active perception. Animals disambiguate between motion in the environment and self-movement using corollary discharge, proprioceptive signals and reafferent sensory input. These signals can also be used to influence information acquisition to optimize sensory processing. I plan to explore the links between oculomotor action and perception during proactive exploration of a visual scene to understand how eye movements reshape processing in the early visual system. Because humans are largely visuals animals active vision is of primary importance to our behavior in our everyday lives. A better knowledge of this phenomenon is relevant to improved understanding of the visual system but will also be relevant to the study of all sensory systems and to a deeper understanding of information processing algorithms, including the value of internal predictive paradigms used throughout the brain. The project has translational potential for the fields of medicine and neural prosthetics, neuromorphic computing, and robotics.

This project combines my previous knowledge in cognitive neuroscience and eye movements, acquired during my 6.5 year stay in the USA with the host laboratorys expertise in low level synaptic system neuroscience. It therefore ensures both acquisition and transfer of new knowledge and opens opportunities of new collaborations. The MSCA Reintegration Fellowship will furthermore give me the opportunity to fully reintegrate in Europe and significantly widen my competences with the ultimate goal of providing the best career possibilities, enhancing the creative and innovative potential, to maximize the contribution of research to the knowledge-based economy and society.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195929;660341;MEDINI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechanism Design under Incomplete Information;1/09/2015;31/08/2017;;"The purpose of this project is to study mechanism design under incomplete information with an emphasis on the design of voting procedures. Mechanism design is the commonly used term for the design of games with a certain objective. For instance, an auctioneer may wish to design an auction with the purpose of maximizing his own revenue. The usual assumption is that the mechanism designer does not know the preferences of the players, but the players do have this information. In this project, the latter assumption is dropped. For instance, in national elections voters have a tendency to vote strategically, and in general only have limited information about the preferences of the other voters. In that case, the objective of mechanism designer (designer of the voting system) is to elicit as much as possible the true votes (preferences), knowing that the voters have beliefs but no complete information about the preferences of the other voters. Specifically, the project will concentrate on three issues: how does correlation between the voters beliefs effect the result of voting and how should the voting system be designed in order to elicit the true votes under this assumption of correlation; can we improve on the results of the first issue by allowing for probabilistic mechanisms, i.e., involve chance; and, following up on this, if truthful voting is out of reach, can we at least get the truthful voting result as an equilibrium outcome. The project is theoretical in nature but can lead to the design of experiments in particular testing the role of belief formation in voting. Further, the results of the project may lead to the design of improved smaller and larger scale voting procedures.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT MAASTRICHT;NL;;; 195889;660104;SIAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sex-Specific Interactions in Arbuscular Mycorrhizas in an Ecological Community Context;13/04/2015;12/04/2017;;"The importance of below-ground organisms for plant growth, plant community dynamics and ecosystem processes is widely recognised. Among them, arbuscular mycorrhizal symbioses are key elements as they mediate plant resource acquisition.
The effects of arbuscular mycorrhizal fungi on plant fitness have been extensively studied in sexually monomorphic plants, but plant populations with separate sexes are relatively common in nature. Usually sexes differ in their resource needs and allocation patterns. Because arbuscular mycorrhizal symbioses mediate resource acquisition and allocation patterns through imposing both costs and benefits to the plants, it is not surprising that sex-specific interactions between arbuscular mycorrhizal fungi and sexually dimorphic plants occur. This is an extremely novel field of research. Most available studies on this topic have been exclusively focused on two trophic levels, neglecting the fact that plants live in complex multi-trophic scenarios, where both mutualistic and antagonistic relationships interact both above- and below-ground.

The aim of this research project is to explore and understand plant arbuscular mycorrhizal fungal interactions in a more realistic multi-trophic context. The essence of the project lies in the interdisciplinary and multidisciplinary approach as it will cover plant and insect ecology, fungal ecology and genetics, and chemical ecology. Implementation of this project has scientific importance for the improvement of our understanding of complex multi-trophic interactions in plants and has potentially enormous economic significance for agriculture as it includes pollination ecology and herbivory.

Besides the scientific importance of the proposed project itself, this project will significantly enhance the applicants career by acquiring up-to-date techniques and other significant skills and provide expertise on mycorrhizal research for the host institution.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LINCOLN;UK;;; 195866;659963;2DSi;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Magnetic Sensors based on Two-Dimensional Materials/Si;3/08/2015;2/08/2017;;Magnetoresistance sensors based on the change in electrical resistance upon an external magnetic field are widely used in day to day applications. The magnetic sensor industry sells billions of dollars worth of sensors every year and there is an ever-growing demand for magnetic sensors with high sensitivity, small size, low power consumption and low cost with compatibility with existing electronic systems. The project aims to develop a new class of highly sensitive magnetoresistance sensors based on doped Si and two dimensional (2D) layered materials, with a focus on single layer graphene and single layer WS2 which could be easily extended to other low dimensional layered materials. This plan will utilize the advantages of tunnelling through SiO2, gate tunability of 2D materials and the geometry of Si to obtain highly sensitive magnetic sensors from Si, which is very unique and novel. The large magnetoresistance observed in graphene by the applicant's group (Gopinadhan et al. Phys. Rev. B 88, 195429 (2013)) can be utilized to get an additional positive change in total resistance per unit applied magnetic field for higher sensitivity. Si can be integrated monolithically, in contrast, 2D layered materials such as graphene possess excellent electrical, thermal and mechanical properties. Its high mobility of carriers are very attractive for high speed applications. The interface between Si and 2D materials are little explored, however there is an enormous technological interest for applications such as graphene-based transparent electrodes in Si solar cells, high speed non-volatile flash memory, microwave switches, voltage controlled diodes, logic devices etc. Furthermore, most of the existing magnetic sensors are electron based and the possibility of both n and p type magnetic sensors due to the electric field tunability of 2D materials may provide new applications such as magnetic sensor and diode (p-n junction) in one active device.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195917;660255;AMIABLE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Advanced MIcroscopy of Attine ant BacteriaL Endosymbionts;1/09/2015;31/08/2017;;"Summary
Most animals crucially depend on bacterial symbionts for digesting food and for optimal health, and such associations are particularly relevant for farming societies that produce their own food. Next to humans, the fungus-growing ants have realized the largest and most complex animal societies on Earth and also these societies depend on the services of multiple bacterial symbionts. The experienced researcher is a cell biologist with state-of-the-art training in electron microscopy who teamed up with the Copenhagen Centre for Social Evolution (CSE) to realize a uniquely interdisciplinary research program of microbial symbiosis. She focuses on three abundant gut bacteria of fungus-growing ants that were recently discovered by the host group, and which appear to function as nutritional and disease resistance mutualists in this complex symbiosis that has become one of the best-studied model systems of social evolution. The objectives of this project are: 1. To reconstruct the acquisition process of symbiotic bacteria during development of individual leaf-cutting ants; 2. To resolve structural adaptations of the bacteria for intracellular versus extracellular lifestyles. Neither of these objectives have been addressed before and both have high potential to change the way in which biologists think about bacterial symbioses. The project includes training-through-research of the researcher in molecular biology, bioinformatics and evolutionary theory, and considerable knowledge transfer in advanced microscopy from the researcher to the CSE host group. The project has been initiated with CSE funding, proven to be very synergistic and highly feasible, and the researcher has already built a collaborative network in Copenhagen. The present application seeks to realize the projects full implementation, allowing the European Research Area to harvest the full benefits of the pioneering work already initiated.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195823;659645;HAPTIFEEL;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Playing by feeling: an investigation of the role of haptic cues in the perceived quality of a musical instrument;1/03/2016;28/02/2017;;"The assessment of the quality of a musical instrument, both from a physical and a perceptual point of view, has been the object of much research in the past and in more recent years. These studies have tried to associate peculiarities in the instrument's mechanical behavior (i.e. its vibrations) to its sound properties, and to how these are perceived by a performer or audience.
A key aspect in the interaction with a musical instrument that is increasingly being investigated, is the haptic feedback which results from the mechanical interaction between performer and instrument. Haptic perception is an umbrella term that encompasses both the tactile and proprioceptive sense, and it is known to be a crucial element in expert music performance.
Even though haptic perception plays such a critical role in musical interaction, relatively little effort has been invested so far into characterizing the haptic behavior of a musical instrument and into how this affects musicians' perception.
With HAPTIFEEL, we aim at developing a methodological framework to characterize the haptic behavior of several traditional musical instruments as perceived by a player. Our methodology will be based on several perceptually-informed physical measurements together with user-based studies which will make use of tactile-augmented digital musical interfaces.";84138,6;84138,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITA DEGLI STUDI DI PADOVA;IT;;; 195930;660343;SURFACE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Human-Landscape-Interactions and Global Dispersals: The SURFACE Record of Palaeolithic Arabia;1/01/2016;30/06/2018;;"SURFACE is an international, trans-disciplinary action combining approaches from archaeology, geomorphology and remote sensing to develop novel approaches to the analysis of the distribution of surface artefacts in arid landscapes. It will use these to address models of human-environment-landscape interactions in Palaeolithic Arabia and their implications for global dispersal of hominin populations.
At a key crossroads of global dispersals, and with a proven but little-studied record of Palaeolithic occupation, Southwestern Saudi Arabia possesses a surface record vital to understanding Pleistocene dispersals out of Africa. How different Homo species (H. erectus, H. sapiens), utilised their landscapes, and subsequent implications for their abilities to disperse from Africa is poorly understood, and interpretation of past hominin landscape use from present-day artefact distributions is not straightforward. Distributions are the sum of varying behaviours over time, while landscape evolution alters the distribution and availability of resources linked to these behaviours (e.g. water, raw materials) and the preservation and visibility of archaeological evidence. It is only by developing a robust, well-dated model of landscape evolution, and detailed recording of surface artefacts in relation to the geomorphological units comprising the landscape, coupled with theoretical paradigms that engage with the variable time depth of surface assemblages that the potential of this record for informing on past hominin-landscape interactions can be realised. SURFACE brings together researchers from the UK and Australia at the cutting edge of developing approaches to the surface record. It will train the ER in these interdisciplinary methods to enable her to fully exploit the globally significant Palaeolithic record of SW Saudi Arabia, and to further develop methodological and theoretical approaches to the surface record, with implications far beyond the time period in question.";216512,4;216512,4;H2020-MSCA-IF-2014;MSCA-IF-GF;University of York;UK;;; 195914;660228;HyHeat;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia;1/09/2015;31/08/2017;;Hyperthermia (HT) is currently used as a non-invasive technique for cancer therapy, whereby biological tissues are exposed to higher than normal temperatures, for selective ablation of tumoral cells. However, the molecular mechanisms underlying the in vivo cellular responses to heat stress remain unclear to date. The overall aim of the HyHeat project is to use an invertebrate model to screen the heating capabilities of different gold nanoparticles (AuNPs) in vivo, with the grand aim of understanding the cellular responses to heat stress and therefore taking the first steps towards improving nanoparticle (NP) mediated HT efficacy for therapeutic purposes. To this end, plasmonic AuNPs with photothermal capabilities will be surface engineered and supplied to living Hydra by soaking. Upon laser irradiation of the animal, cellular and molecular expression will be profiled to monitor the overall response to NP-mediated HT. A simple invertebrate organism will be used, in line with European strategies aimed to reduce vertebrate experimentation. Once a panel of upregulated genes have been identified, the research will be conducted in mice analyzing those genes found deregulated in Hydra with the final aim to identify genetic markers of HT treatment and speed up the entry of this therapy into clinics. HyHeat is a multidisciplinary project that take advantage of the Fellows Dr. Maria Moros knowledge in the synthesis and functionalization of NPs, and the expertise of the host group supervisor (Dr. C. Tortiglione, Instituto di Cibernetica Eduardo Caianiello (ICIB), National Research Council (CNR), Italy) in molecular biology using invertebrate models. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of Hydra to test bioactivity and toxicity of NPs, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195864;659937;AGEISM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Lifelong health, markers of ageing and senescence in a long-lived mammal.;1/01/2016;31/12/2017;;"Given the ageing population in Europe, it is critical to understand the mechanisms involved in growing old. Our ability to reduce the impact of ageing in humans might be best studied in equally long-lived animals. Predicting future changes in longevity patterns might depend on our ability to develop indicators of how old we really are and how many healthy years we have ahead of us, and how those indicators depend on our health history across decades.
My study will be the first linking lifelong disease history with physiological and molecular measures of ageing in a mammal as long-lived as humans. I will examine how different molecular ageing markers (telomere dynamics, oxidative stress and telomerase activity) interact with lifelong disease and reproductive history, and current endocrinological measures of stress and reproduction. This helps to better grasp both the mechanisms of ageing and their consequences on senescence rates, thus providing exceptional opportunities to identify the exact role of these markers in evolutionary processes and how they determine ageing rates and individual variation in senescence rates. It would also help us to establish which molecular markers best represent individual health history and to understand how health history can predict ageing rates. To do so, I will combine the world's most comprehensive demographic data on Asian elephants with bi-monthly health and disease records across life and with molecular ageing markers and hormonal correlates of stress and reproduction (N~240).
I will determine:
Q1.How does health decline with age?
Q2.How does lifelong disease exposure and current health link with ageing markers?
Q3.How does reproduction affect age-specific declines in health and current ageing markers?
Q4.How does early stress affect age-specific declines in health and current ageing markers?";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195800;659478;BIMEDA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Big Medical Data Use in Primary Care: an ethnographic, socio-technical, investigation of challenges and opportunities;1/08/2015;31/07/2017;;"Big medical data analytics is a new and unique opportunity for national health systems to reduce costs and improve population health management. The processing of vast amounts of medical histories from electronic patient records can provide researchers, clinicians, policy makers and private health companies with invaluable insights into all aspects of health and illness. New treatments, medication regimens and medical technologies can then be developed based on more accurate cost/benefit analyses. Importantly, it constitutes national health systems engines of economic growth. The European Commission is actively promoting a Digital Agenda for Europe, where more Open (Government) Data will support and accelerate the development of A Thriving Data-Driven Economy. However, the European Agency for Fundamental Rights is working to address social, legal and ethical implications from surveillance activities and data protection mishaps, particularly for personal health information.
The aim of the BIMEDA project is to elaborate a theoretical framework for critically analysing social, technical and ethical challenges from big medical data analytics, through the mapping of the data protection controversy of the Care.data programme in England and the ethnographic study of an academic and a private organisation that collaborate to collect and analyse big primary care data analytics. It brings together a talented researcher with background in qualitative research of clinical information systems implementation and use from a Science and Technology Studies perspective to work with an internationally renowned host institution (University of Nottingham) in big primary care data analytics and, healthcare organisations and (Horizon) Digital Economy research in order to identify and clarify, for policy-makers and the public, possibilities, limitations, assumptions and biases in research, knowledge production and ethical conduct.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF NOTTINGHAM;UK;;; 195807;659530;cRISys;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Innovation Systems in Financial Crisis: Technological Dynamics, Industrial Structure and Business Cycles;30/06/2015;29/06/2017;;"This research project will investigate from an empirical, theoretical and normative perspective the impact of financial crisis on innovation systems, and in particular knowledge networks and technology clusters, and by extension, on technological trajectories, industrial dynamics and economic growth of afflicted EU economies. It will also explore the latent link between technological dynamics and business cycles, and examine to what extent a strategic mix of RTDI, industrial and regional policies can address structural causes of crises and foment techno-economic development by building the capacities of innovation systems and bridging the technology gap.
The project will apply econometric modelling, network analysis, and computational simulations at various geographical scales, from NUTS-3 regions to the EU as a whole, focusing on three Southern European countries (Spain, Portugal and Greece). At the theoretical level, it aspires to bridge the gap between neo-Schumpeterian technological dynamics and post-Keynesian macroeconomics with endogenous fluctuations, and to build an agent-based model of an innovation system for policy simulation. This is expected to shed light on the latent link between business cycles and technology gaps, to gauge the technological impact of financial crises, and to assess alternative policy responses under different institutional settings.
The project is highly topical in the context of post-crisis EU policy discourse on the future of ERA, the Innovation Union initiative and Europe 2020 growth strategy, and it can advance the design of knowledge governance policy instruments for crisis-hit EU periphery, thus having a positive societal impact. It is also designed to boost the researchers academic career restart, to consolidate his expertise in the field of innovation and technology economics, and to enrich his research skills by providing advanced training and opportunities for international research collaborations and dissemination.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITAT DE BARCELONA;ES;;; 195700;659001;CNT-Nanostickers;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Anisotropic High-Density Carbon Nanotube Coatings for Thin-Film Electronics;1/07/2015;30/06/2017;;This project proposal aims at developing a new manufacturing technology for processing nano-materials by combining emerging scientific insights in nanoparticle assembly with scalable production processes. Our goal is to establish the first scalable technology to make thin-films comprising densely packed aligned Carbon Nanotubes (CNT) of highest quality. These films will be fabricated by controlled wet deposition and transfer techniques, and used as a high-performance material for device fabrication. On the longer term, the same principles could be extended to the production of transparent conductors, sensors, and to variety of other applications. As a demonstrator, horizontal CNT-interconnects targeting a resistivity below 100??cm will be fabricated. At this value CNT become a viable alternative to Copper in Microelectronics. This disruptive push of CNT-interconnects into commercially competitive specifications will be enabled by: the superior quality of the CNTs used in the CNT-films, advances in their transferring, the skillset of the host-group in nanoparticles assembly and manufacturing processes and the 7-years expertise of the applicant in CNT-interconnects. The network of both participants in various European countries and the assistance of IMEC (Belgium), partner organization to this project, will facilitate the implementation of this research for enabling a true industrial impact on EU economy.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 196043;661063;EQUIP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Elemental quota in marine phytoplankton for effective carbon sequestration, clean energy and biogeochemical modelling;7/05/2015;6/05/2017;;"Understanding element assimilation and allocation in marine phytoplankton is key to developing effective strategies for phytoplankton based clean energy generation and carbon sequestration. It is also fundamental to the development of biogeochemical models for predicting climate change. In this project, we will describe the element composition of diatoms, dinoflagellates and coccolithophores that are key players in global biogeochemical cycles, and have the potential to be used for carbon sequestration and as clean energy feedstock. We will use a novel single-cell method that employs X-ray microanalysis (XRMA) to overcome current pitfalls of overestimations and non-specificities in determining element compositions. The results will be corroborated with time-of-flight secondary ion mass spectrometry (ToF-SIMS), as a novel complementary approach for the purpose, expertise for which is available at the host laboratory that the fellow will get trained in. We will study element assimilation in monocultures under controlled conditions and relate it to field phytoplankton samples obtained from the Western Channel. Outcomes of the proposed work include: ranking of the three phytoplankton groups for use in clean energy generation and carbon sequestration; assessment of the degree of divergence in element composition between the representative species, environmental conditions and physiological states; first-of-its-kind single-cell analysis of phytoplankton, both cultured and from the field; accurate conversion factors to be used in global biogeochemical models; expertise imparted to the host laboratory in XRMA analysis, phytoplankton biogeochemistry and ecological perspectives for bioenergy generation and carbon sequestration; expertise imparted to the fellow in ToF-SIMS analysis, biochemical characterisations and laboratory culturing of phytoplankton, along with several professional skills available at the host organisation for development as an independent researcher.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;THE UNIVERSITY OF SHEFFIELD;UK;;; 195871;660003;FraxiFam;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Reconstructing gene family evolution in the ash genus (Fraxinus;1/07/2015;30/06/2017;;Comparisons among whole genome sequences allow us to survey differences in gene content among organisms, and hypothesise patterns of gene gain and loss through evolution. Rates of gene flux appear to be surprisingly high, and many genes are unexpectedly unique to species (orphan genes). In plants, increasing evidence suggests that genome evolution has been shaped by multiple rounds of whole genome duplication (WGD) after which many duplicated genes are lost, but some duplicates are retained and diverge. The extent to which novel genes arise due to WGD, tandem duplications, horizontal gene transfers, or de novo, remains an open question, especially in plants where WGD seems to be such a pervasive feature of evolution. Our knowledge is hampered by the fact that until now we have been limited to comparisons of whole genome sequences in plants that are highly diverged from one another. This means that the early consequences of gene duplication, and the early divergence of duplicated genes, have not been studied on a genomic scale. This project will use a new dataset, generated by the host lab, containing the whole genome sequence of every species within a plant genus (the genus Fraxinus ash trees). As well as having inferred WGDs in its ancestry, this genus contains species that have undergone recent WGD. We propose to conduct a comprehensive analysis of gene and gene family evolution in this genus, compiling a major public database of Fraxinus gene families (FraxiFam). Using this data we will conduct the first genome-wide and genus-wide study of gene content evolution, allowing us to study the early stages of gene sequence and gene content divergence. We will test hypotheses about: (1) the primary drivers of gene content evolution, (2) the repeatability of patterns in gene loss and retention after WGD, and (3) the early evolution of orphan genes. This research will contribute to attempts to develop ash trees resistant to ash dieback, for EU ecological restoration.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195846;659774;Pro-Oxides;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Properties of metal oxides for electronic and optoelectronic devices;1/04/2015;31/03/2017;;Metal oxides are a versatile group of semiconductors that are employed in a broad range of applications including micro/nano-electronics, photocatalysis and thin-film devices. The strength of metal oxides for these contemporary applications resides in the diversity of the electronic and optical properties which determine energy-level alignment and consequently dictate device performance. Furthermore, metal oxides exhibit a sensitivity to stoichiometry, unique among semiconductors, that permits fine-tuning of these properties. This feature offers an elegant yet simple method for additional performance optimisation. However, it requires a deep understanding of the relationship between the stoichiometry of metal oxide compounds and the aforementioned properties that is currently lacking. In this proposal we will fabricate metal oxides with a spatial gradient in chemical composition and characterise the optical, electrical and chemical properties with high-throughput scanner, at an unparalleled rate. From these results we will establish the correlation between these properties and the exact chemical composition for a multitude of compounds. In addition, a model to describe the alignment of energy-levels across metal oxide/metal oxides interfaces will be developed. The present proposal will address the disparity of reported information for metal oxide properties arising from poor chemical analysis and greatly advance the engineering capabilities of thin-film technologies. The research described here is designed to integrate seamlessly and strongly support the All Metal-Oxide Photovoltaic project under the Seven Framework Programme.;170509,2;170509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BAR ILAN UNIVERSITY;IL;;; 195892;660122;CRYPTRANS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of newly discovered but poorly understood fungal-driven trophic processes in freshwater lake ecosystems by metatranscriptomic;1/07/2015;30/06/2017;;Recent research has shown that freshwater systems, and particularly their deepest parts, abound with fungi. These fungi (predominantly in the poorly understood phyla Chytridiomycota and Cryptomycota) are largely new to science and are thought to be involved in ecological processes that convert organic matter into nutrients readily accessible to organisms at higher trophic levels. Given the ever-increasing anthropogenic pressure on freshwater systems, we need to understand these processes and the organisms involved in substantial detail. The present project will characterize these new fungi and detail the processes and ecological services they drive through next-generation sequencing of DNA (metagenomics) and RNA (metatranscriptomics) pools in freshwater depth gradients. The overarching questions are: (1) What fungi are down there? (2) What are their functions and roles? and (3) What are the implications for the study of fungi, freshwater ecosystems, and ecology at large? This combination of taxonomy/systematics and ecological/functional research questions applied to these most unexplored and remote ecological settings represents a novel approach on freshwater systems and biological diversity - one with the potential to redefine the pursuit of biological research questions across biological disciplines and beyond habitats normally targeted. The applicant has developed a new high-tech sampling device capable of stable RNA/DNA capture down to 100 m depth, and he brings substantial expertise on functional and ecological assessment of metagenomics sequence datasets to the project. The host research group is the world authority on molecular identification of fungi and comparison of fungal communities across sites and locations. Jointly this team is in a position to push the boundaries of biological knowledge, with the ultimate intent to allow the applicant to establish a progressive, vibrant research group at the very forefront of freshwater systems research in Europe.;185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 195978;660643;BT-LH Link;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The consequences of the joint individual variation in size specific life histories and behavioural types;1/06/2015;31/05/2017;;"Individual variations in body size and in behavioural types within a population have, each separately and in isolation, been shown to strongly determine the dynamics and stability of populations and their responses to perturbations and environmental change. However, both aspects of individual trait variation are fundamentally joined by their influence on individual life history traits which ultimately determine population level phenomena through individual growth, maturation, reproduction and survival. Taking this interplay into account can be argued to affect and even reverse predictions of each stand-alone approach. For this reasons, the proposed research project will, using an experimental system with the model species Heterandria formosa that combines individual level and long term population level manipulations, investigate the consequences of and mechanisms behind body size specific, density dependent life history traits linked to behavioural types. Clear hypotheses about total population density, population size structure and dynamics in constant and stochastically variable food environments will help to separate the effects of different sources of individual trait variation and investigate their joint population level effects. After a time of onceptual theorizing, experimental data are now desperately needed to confirm, test and further develop novel ideas and concepts. By integrating two so far isolated approaches (advanced behavioural biology and state-of-the-art population theory) the project will thus contribute to the current paradigm shift in population ecology which is increasingly focusing on the consequences of individual trait variation, helping to formulate a more comprehensive and synthetic theory of population
biology.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FORSCHUNGSVERBUND BERLIN E.V.;DE;;; 195874;660028;ExTRyG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Excitonic transport in cold Rydberg gases;1/11/2015;31/10/2017;;"The study of transport phenomenon based on quantum processes, where energy and information are transported but neither charge nor mass, is a vivid and interdisciplinary field of research raising both fundamental and technological issues.
During this fellowship, we propose to use laser-cooled ensembles of atoms in highly excited states (cold Rydberg gases) to study such transport phenomenon.
The overall purpose of the action is to demonstrate that cold Rydberg gases can be used as an innovative, efficient research platform which would allow to further address fundamental challenges related to the transport of energy and information.\\
The principal objective of this project is to form a chain of Rydberg atoms, to locally place an additional electronic excitation (exciton) in the chain and to observe the subsequent transport dynamics.
A second objective is to implement adiabatic excitation of collective Rydberg excitations in order to prepare deterministically a Rydberg chain.
This project will be implemented in a world leading group in cold Rydberg gases where the applicant will use two complementary experimental setups to address the different aspect of the objectives in the best conditions. He will be supervised by their respective principal investigators which will provide a strong management structure to the project.
Building around the applicant's experience in the field of cold Rydberg gases, this fellowship will provide him with new, cutting-edge experimental skills which would establish him as a leading researcher in this field. The innovative, high quality research which will be carried out during this fellowship will serve as a basis for the application to a permanent position.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Durham;UK;;; 195851;659826;MEMBRANEPROT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Membrane proteins development of new computational approaches and its application to G-Protein Coupled Receptors;1/03/2016;28/02/2018;;Protein-protein tridimensional (3D) structures are fundamental for structural biology and drug discovery. Many docking algorithms were developed for that purpose, but they have limited accuracy in generating native-like structures and identifying the most correct one, particularly in the case of membrane proteins such as G-protein Coupled Receptors (GPCRs). In order to deal with these complex systems and overcome the limitations of existing software, we will develop and optimize computational approaches and construct novel combinations of mature methodologies, to serve in the study of membrane proteins in general. In particularly, we will focus in: i) improving the search and scoring algorithms for the docking process of membrane proteins, ii) developing software to accurately predict the high-order oligomers interfacial residues, and iii) constructing a docking algorithm able to predict their 3D oligomeric structure. Our new approaches will be applied to a relevant biological system: the dopamine receptor type 2 (D2R), a typical member of Class A GPCRs involved in many cognitive, emotional and motor functions. D2R acts by ligand-dependent signalling through two major systems: the G-proteins, and the Arrestin proteins (Arr-s). How ligands determine the preference for one or the other is not yet understood at the molecular level, and this precludes both the characterization of pathway selectivity and the design of biased ligands. More importantly, the physiological relevance of oligomerization for this process is still topic of vigorous debate. Therefore, building on both my unique expertise and Prof. Bonvin well-known impact in methodological development, this project will yield novel methods and approaches to serve in the study of membrane protein systems and their functional mechanisms, benefiting the entire research field. It will also provide truly new fundamental knowledge and insights into the selectivity of D2R signalling.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 195808;659534;FCSM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biophysical Properties of Human Foetal Cardiac and Skeletal myosins;1/06/2015;31/05/2017;;In utero development is critical for normal skeletal and cardiac muscle function throughout life. Many diseases, such as distal arthrogryposis (affecting 1/3000 live births) and clubfoot (1/1000) in skeletal muscle and arrhythmias in cardiac muscle (1/4000), manifest in the embryonic and foetal period. They permanently affect longevity and quality of life. Because the effects of these diseases are present at birth, the study of in utero samples is essential to understanding the diseases properties and effects on the developing muscle tissues. Additionally, many of these afflictions are caused by mutations in the isoforms of troponin or myosin II that are predominantly expressed during human development. Studying the native muscle is all the more important as a control in furthering research on the effects of mutations in troponin and myosin. In particular, human foetal-specific isoforms of myosin II expressed in these muscle are poorly understood and very little has been published about these isoforms. We do know from the literature that myosins use of its substrate, ATP, varies widely between isoforms and that the myosin expression changes during times of physiological distress, such as heart failure. Because congenital abnormalities of the heart and skeletal muscle both can originate in the foetal muscle, further investigation is needed into the myosins biophysical and biomechanical mechanisms. The overarching goal of this project is to improve understanding of how foetal forms of skeletal and cardiac myosins work and are regulated by troponin in muscle, using biophysical-biochemical, molecular biology and computational modelling techniques. The fellow will do this by experimentally determining the kinetics of myosin-ATP, myosin-actin and myosin-actin-troponin-tropomyosin interactions using stopped-flow kinetic analysis, and then use the parameters defined to inform the computational models developed by Dr. Geeves.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF KENT;UK;;; 195915;660230;EPICONNECT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Functional brain networks in epilepsy;1/01/2016;30/06/2018;;"This proposal for a Marie Sklodowska-Curie Global Fellowship is meant for the training of Dr. Pieter van Mierlo, currently at Ghent University, in the Functional Brain Mapping Laboratory (FBM Lab) of the University of Geneva, one of the world leading brain imaging laboratories. The goal of the project is to explore the communication between brain regions in epilepsy patients to ameliorate their treatment.
In the first stage a non-invasive tool, ElectroEncephaloGraphy (EEG), will be used to measure the electric field of the brain through electrodes placed on top of the scalp. By measuring the voltage difference between the EEG electrodes the electric field of the brain can be studied with a high temporal resolution (ms). Recently, high density EEG (hd-EEG) systems have been developed with up to 256 electrodes. These systems allow more accurate measurements compared to the old systems having only 32 electrodes. The FBM Lab is one of the few labs that have hd-EEG recordings of epilepsy patients. In this project we will develop an algorithm to investigate the brain networks in epilepsy patients based on hd-EEG recordings. The brain networks will be studied to localize the epileptic focus, the brain region that causes the seizures.
In the second stage hd-EEG will be combined with functional Magnetic Resonance Imaging (fMRI) that images the concentration of oxygen in the brain with a high spatial resolution (mm). The simultaneously recorded hd-EEG / fMRI allows studying the brain networks with both a high temporal and spatial resolution. Furthermore, fMRI is more sensitive to record brain activity of deep brain structures compared to hd-EEG. The added value of combining hd-EEG with fMRI to localize the epileptic focus will be assessed.
In the third and final stage, the developed algorithms will be implemented at the UGent. A prospective study will be done to quantify the influence of functional connectivity analysis on patients treatment management.";211964,7;211964,7;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITEIT GENT;BE;;; 196028;660985;REPTIMORG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;DNA replication timing and spatial organization of chromatin;1/07/2016;30/06/2018;;Replication timing is observed in all eukaryotes analyzed so far suggesting an important and conserved function. Despite significant advancement in the field, the molecular control of the replication-timing program is still largely unknown. The Buonomo laboratory has recently done very innovative work in this area. After identifying Rif1 as the only known global regulator of replication timing in mammalian cells, they have further shown that Rif1 controls chromatin architecture during replication-timing establishment. This provided the first molecular evidence linking 3D nuclear organization and replication-timing control. However, Rif1 is a complex protein whose structure-function is not fully understood and it is not clear yet if the link between 3D nuclear organization and replication-timing control is specific to Rif1 or a general paradigm. A major aim of this proposal is to investigate if chromatin architecture plays a general role in replication-timing control. To this end, I will perform replication-timing and chromosome-conformation studies using mouse models which allows me to conditionally delete genes encoding for key regulator of nuclear structure, such as cohesin (Rad21) and Lamin B1. I aim with this proposal to advance the understanding of how spatial organization of chromatin regulates and integrates different nuclear functions, with a specific focus on DNA replication.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195849;659791;EpiSpec;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;EPIgenetic impacts on early-stage SPECiation and adaptive radiation;1/04/2015;31/03/2017;;Phenotypic plasticity plays a key role at the onset of the speciation process, facilitating diversification though the induction of novel phenotypes in response to distinct environments. Via genetic accommodation and genetic assimilation, this influence may extend throughout the speciation process and beyond, into subsequent speciation events. While the epigenetic regulation of gene expression that mediates phenotypic plasticity has been extensively studied in lab-based model organisms, very little is known about epigenetic variation in natural populations. This project will be the first epigenetic study explicitly focused on the speciation process. Using cutting-edge techniques, the applicant will characterize DNA methylation variation within and among the sympatric species of a recently discovered endemic cichlid fish radiation in Lake Massoko, Tanzania. Specifically the applicant will test: if 1) newly formed species differ in the distributions of epigenetic marks across the genome, 2) genomic variants linked to phenotypic divergence among species are in genomic regions unusually high in DNA methylation, as expected under a hypothesis of epigenetic differences preceding fixed nucleotide differences during adaptive divergence, 3) genomic regions diverging in patterns of methylation among incipient species are also exhibiting high levels of methylation in populations of Astatotilapia calliptera, the ancestral, colonizing species. The results of this pioneering project will provide the first empirical evidence of the importance of epigenetic variation during the emergence of new species.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195963;660532;SuperMag;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cooperation between Superconductivity and Magnetism in Mesoscopic systems: towards Majorana states;1/07/2015;30/06/2017;;"A major challenge in contemporary physics is to understand and control unconventional states of matter, such as topological superconductors and Majorana fermions (MFs). Once harnessed, this physics offers bright prospects for low-power superconducting digital electronics and fault-tolerant quantum computation. Recent proposals showed that ordered chains of magnetic impurities, in proximity of a superconductor, can hold a MFs. This state come from a precise cooperation between superconductivity and magnetism.

I propose to study this cooperation in a unique system consisting of a nanoscopic metallic island where these two mechanism can be, for the first time, independently controlled. Specifically I will combine two novel technologies for my studies: (i) the superconducting quantum interference proximity transistor (SQUIPT) and (ii) the molecular spin doping. The SQUIPT is a novel device composed by a nanoscopic metallic island in proximity of a superconducting loop able to induce and control superconductivity in the normal metal, whereas molecular spin doping allows for controlled chemical deposition of magnetic impurities in the same normal metal.

My first objective is to study the competition/cooperation between the magnetic and the superconducting correlations induced in the electrons of the nanoscopic metallic island by measuring the amplitude and phase of the superconducting Josephson current. Secondly, I will investigate the effect of the magnetic impurities on the quasi-electrons density of states in such junction.

Successful combination of my bottom-up and top-down approaches will contribute at first instance to the understating of this fundamental competition/cooperation and later to the highly sought-after and ambitious target of the demonstrating MFs in the solid-state. Tunnel spectroscopy measurements of the SQUIPT will reveal the MFs that, at cryogenic temperatures, can emerge in the metallic island properly doped by the magnetic impurities.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195685;658914;MorpheuS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hybrid Machine Learning Optimization techniques To Generate Structured Music Through Morphing And Fusion;1/06/2015;31/05/2017;;"State-of-the-art music generation systems (Continuator, OMax, Mimi) produce music that sounds good on a note-to-note level but lacks critical structure/direction necessary for long term coherence. To tackle this problem, we propose to generate compositions based on structural templates at varying hierarchical levels. Our novel approach deploys machine-learning methods in an optimization context to morph existing pieces into new ones and to fuse different styles.

We aim to develop a framework that combines machine learning techniques that learn style, with a powerful optimization method, the variable neighbourhood search (VNS) algorithm, for generating music. This approach allows the learned model to incorporate a wide variety of constraints, including those for preserving long term coherence and structure. It promises to effect a step-change in automatic music generation by moving the field in the new direction of generating structured music using hybrid machine learning-optimization techniques.

The applicant is an operations researcher-musician, ideal for this work. A first step combines her VNS music generation algorithm with machine learning methods to ensure proper style evaluation. In previous work, the applicant has shown that VNS outperforms genetic algorithms when generating counterpoint with a rule-based objective function. In a preliminary study, the applicant has demonstrated the effectiveness of using machine learning techniques as evaluation metrics for optimisation methods. The applicant has extensive web development experience; to reach the widest possible audience, the resulting system will be made available in an interactive website where users can morph and fuse musical pieces.
This work is situated in the area of digital media, with a European consumer expenditure of over 33 billion in 2011, projected to increase. Music generation in digital music has direct applications in game music, interactive arts, and stock-music for advertising/videos.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195877;660034;THSExposure;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Thirdhand Tobacco Smoke: Chemical Characterization, Human Exposure and Urinary Carcinogen Biomarkers;15/09/2015;14/09/2017;;"Tobacco smoking is the leading cause of preventable disease worldwide. Compared with the rest of the world, the WHO European region has one of the highest proportions of deaths attributable to tobacco. Although most of EU countries have introduced smoking bans in public places, domestic environments are still an important source of passive smoking exposure. Environmental tobacco smoke contains more than 4,000 chemicals many of which are toxic and carcinogenic and is estimated to be the cause of about 1.0% of worldwide mortality. In addition to passive inhalation, non-smokers, especially children, are also at risk through contact with surfaces and dust contaminated with residual smoke gases and particles, the so-called thirdhand tobacco smoke (THS). Despite the emerging evidence on THS harms, the specific role of THS in tobacco-related illnesses has been questioned so far by the public health community because of the poor level of characterisation of THS constituents and mechanisms of formation, as well as the lack of studies focused on human exposure.
The aim of this proposal is to fill some of the important gaps on our current understanding of the chemistry, toxicology and exposure of THS, including an accurate characterisation of THS composition and the development and validation of specific human urine biomarkers of this exposure. The developed tools will be used for the monitoring of matching samples of THS from smoking and non-smoking houses and human urine from their households in order to find correlations between tobacco exposure and urine biomarkers. The final objective of the proposal is the public diffusion of the results obtained in this study as evidences of THS harms to influence in present and future health educational programs, especially addressed to smoking parents, and in present and future European health policies.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA PERE VIRGILI (IISPV);ES;;; 195856;659901;CLIMAGNET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;How is the external climatic forcing affected by the Earths magnetic field?;1/02/2016;31/01/2018;;"The rate of production of cosmogenic isotopes plays an important role in our understanding of past climate variability since they provide information about the solar irradiance related to the Suns magnetic field. Having reliable information about past changes in solar irradiance is important for the development of climate model simulations driven by reconstructions of past natural and anthropogenic forcings. One of the sources of uncertainty that affect reconstructions of solar variability is that not only the influence of the solar magnetic field is recorded by the radionuclides; the strength of the Earths magnetic field also contributes to modulate the rate of isotope productions. In this context, an appropriate knowledge of the past global geomagnetic field variations is crucial to define the total solar irradiance and hence, to improve reconstructions of external forcing. The past evolution of the geomagnetic field can be recovered from rock samples. The main differences between model predictions are related with the filter applied to the palaeomagnetic data. Up to now, these filters rejected the data according to the measurement and age uncertainties. However, this procedure does not consider the quality of the laboratory protocol or the number of specimens, and hence geomagnetic field predictions might be affected by some unreliable data. Currently, the non-appropriate application of these filters generates spurious variations in the geomagnetic model predictions and these biases are transferred to the reconstruction of the solar variability and consequently to the climatic model simulations. The CLIMAGNET project is aimed to resolve this challenge in two scopes: a) the construction of a global geomagnetic model for the last eight millennia using an appropriate weighting scheme of the palaeomagnetic data; b) the study of the relation between the geomagnetic model predictions and the production rate of cosmogenic isotopes using novel approaches.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD COMPLUTENSE DE MADRID;ES;;; 195859;659912;IRC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Imagination and Religious Credence;1/06/2015;31/07/2016;;"'Many philosophers and cognitive scientists have a habit of using the word belief as though it refers to a single, simple sort of cognitive attitude. But if we take empirical evidence from cognitive science of religion seriously, we will see that this habit is a source of confusion. Just as it is a mistake in astronomy to assume that Venus and the North Star are the same kind of entity because they are both stars, so too it is a mistake in theorizing the nature of belief to treat what I call religious credence and what I call factual belief as the same type of attitude. I have already argued in my paper Religious Credence is not Factual Belief (forthcoming, Cognition) that our best psychological theory of cognitive attitudes, in conjunction with psychological and anthropological evidence, will treat these two attitudes differently. The research aim of the project proposed here is to elaborate on my theoretical apparatus to produce a book-length monograph that will serve philosophers and cognitive scientists interested in religious belief,' and the corresponding aim for public dissemination is to make this research popularly available through essays, blogs, radio, and public debate.
I propose to write _Imagination and Religious Credence_ while in residence at the Centre for Philosophical Psychology at the University of Antwerp. This will be an important step in my career development. My career aim is to achieve a level of distinction in research that will justify (1) mentoring PhD and postdoctoral researchers and (2) directing a research group similar in structure to the Centre for Philosophical Psychology. Advancing my own research and being embedded in the Centre, which has a stellar history of developing research careers, will both be critical steps toward realizing these career goals.'";93800;93800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT ANTWERPEN;BE;;; 195785;659401;YIELDFACTOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Using SP1 to control plastid development and yield in cereals;7/03/2016;6/03/2018;;"Recently, the host lab found that a novel ubiquitin E3 ligase, SP1, regulates the translocon of the outer chloroplast membrane (TOC), which is responsible for importing nucleus-encoded proteins into plastids. SP1 achieves this by promoting the degradation TOC components by the cytosolic 26S proteasome. This is the first time the ubiquitin proteasome system (UPS) has been shown to directly regulate plastid development and function. By increasing or decreasing SP1 levels in transgenic Arabidopsis plants, multiple effects of SP1 were observed; e.g., inefficient de-etiolation leading to low survival rates and delayed leaf senescence in sp1 null mutants (Science 2012, 338:655-9). Also, sp1 mutants are significantly more sensitive to stress (unpublished). These data suggest that SP1 is important for the differentiation and interconversion of different plastid types, and all of the effects are highly correlated with plant growth and yield. Thus, discovery of SP1 strongly suggests potential applications in agriculture, such as delaying leaf senescence to produce a staygreen phenotype, or controlling amyloplast development during grain development, by modifying SP1 expression. This project will investigate the function of SP1 in cereals, and assess the potential of SP1 for manipulating plastids to improve cereal yield. I will generate transgenic plants with manipulated SP1 expression in Brachypodium distachyon (a versatile cereal model) and Oryza sativa (rice). I will study the development of plastids in the transformants, and assess the transformants for beneficial effects on yield parameters, such as starch content, seed weight, germination, de-etiolation, leaf senescence and stress resistance. At the end, I will have thoroughly assessed the potential use of SP1 for manipulating cereal traits linked to yield. A major strength of the proposal is the complementarity of my expertise with that of the host. Our unique combination of skills will ensure success of the project.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195831;659671;ENGAGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Encouraging Network Generations Accountability and Global Engagement;1/09/2015;31/08/2016;;"The key aim of ENGAGE is to address young people's participation in society via social media. ENGAGE focuses on understanding new forms of political and civic engagement within the digital visual cultures and social networked societies that young people from Norway and the United Kingdom are a part of. Through a comparative study focusing on two cities, Sheffield and Oslo, the project will explore how social, cultural and political events are experienced and expressed through images by young people in everyday contexts of digital socialization. To address these aims the project will draw on feminist media approaches, photo theory and debates within post-structural theory and philosophy. It will advance an innovative methodological approach, using digital ethnographic methods in alignment with network analyses and computational Big Data methods and techniques. In order to encourage young people to become responsible citizens and actively engage in civic and political society, we need more insight into the recent explosive growth in image sharing, giving rise to an emergent visual digital media public. With an interdisciplinary approach, triangulating small- and big-scale social media image data, theory and methods; this project has the potential to significantly contribute to our understanding of this emergent visual digital media public in Europe. The Information School, at the University of Sheffield will host the Individual Fellowship. Specifically it will be located within the Visual Social Media Lab (VSML), led by Dr.Vis, who will supervise the project. The Fellowship will also be in close collaboration with The Sir Bernard Crick Centre for the Public Understanding of Politics (SBCC) . The Individual Fellowship has the potential to offer excellent impact for Dr.Pritz' career: it is a significant and exciting opportunity to acquire and transfer knowledge, and offers the potential for long-term collaboration between the iSchool, Dr Vis, VSML, SBCC and Pritz.";97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195902;660156;FLUOROKEF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Incorporation of unnatural fluorinated amino acids to probe the function of the bacterial efflux system Kef in a cellular setting.;1/10/2015;30/09/2017;;"The potassium efflux system, Kef, protects bacteria against the detrimental effects of electrophilic compounds via acidification of the cytoplasm. Its vital role in maintaining cell homeostasis makes Kef a promising target for antibiotics, but such drugs can be developed only with a molecular understanding of Kef activation. Our work indicates that phenylalanine residue 441 (F441) in Escherichia coli is crucial for the activation of K\ efflux. This mechanism is conserved, and F448 of Shewanella denitrificans Kef (SdKef) has the same function. This work employed X-ray crystallographic studies using a truncated construct of the E. coli Kef soluble C-terminal domain (EcKefCTD) and biophysical studies conducted on the SdKef C-terminal domain (SdKefCTD). While the crystallographic studies have been essential in hypothesis generation, they lack the dynamic aspect that is required to understand the mechanism of Kef activation. Although the use of a truncated construct has allowed development of biophysical assays, we wish to extend our work to focus on the full-length channel. To achieve these aims we will employ whole cell 19F NMR to probe the function of Kef.

To determine if 19F NMR can be used to monitor F448 conformation, we will employ amber stop codon technology to replace F448 of SdKef with 4-trifluromethyl-L-phenylalanine (tfmF). We will monitor the dynamics of F448tfmF by 19F NMR upon binding of activators and inhibitors, using our library of SdKef ligands. To gain an understanding of Kef activation in cells, we will quantitatively determine binding affinities of the Kef ligands to SdKef(F448tfmF), in E. coli transformants using in-cell 19F NMR. This direct determination of binding inside the cells will be more physiologically relevant than the in vitro KD data. To assess the antibiotic activity of compounds that show cellular activity against Kef, we will employ the Kirby-Bauer disc diffusion method to screen for compounds that can kill bacteria.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195836;659706;AdvancedStarForm;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Global and local star formation with state-of-the-art physics;1/09/2015;31/08/2017;;"New stars form within large turbulent complexes harboring several thousands of solar masses of cold gas: the molecular clouds. The diffuse gas collapses gravitationally and heats up via compression until nuclear fusion reactions ignite and the star comes to life. The full description involves an intricate interplay between large-scale environmental factors and small-scale processes close to the star, connecting a number of physical mechanisms, including magnetic fields, self-gravity, radiative transfer, and time dependent chemistry.

The aim of the project is to construct a unified description of star formation, from large to small scales, using the world's most advanced numerical physics. A two-way approach will be used: the global approach (I) will deal with the dynamics of interstellar gas on the turbulent cloud scale, while the local approach (II) will concentrate on the formation of the protostellar seed.

The objectives are:

- Ia. Carry out a parameter study of the effects of cloud mass, turbulence, radiative transfer, and magnetization on stellar populations in giant molecular clouds
- Ib. Create a realistic model for protostellar radiative and outflow feedback and examine its effects on the star formation efficiency
- Ic. Quantify the effects of supernova-triggered star formation
- IIa. Simulate the formation of single protostars using extremely detailed physics (non-ideal MHD, multi-frequency radiative transfer)
- IIb. Incorporate for the first time into the simulations a chemistry module which interacts with the gas and radiation field
- IIc. Study episodic accretion events in protostars to try and explain under-luminous young stellar objects.

This is an ambitious, strongly multidisciplinary program, which fits perfecty in the research activities of the host institute. To ensure the project's success, I have a proven record of working with the different numerical techniques required, as well as an excellent understanding of astronomical observations.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195792;659446;smSTRUCT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Fuse smFRET and modeling to a new structural biology method and solve the functional ESCRT assembly structure;1/01/2016;31/12/2018;;"We seek to develop a new structural biology method that is able to overcome barriers to solving very complex functional protein assemblies that are variable enough in their composition and conformation to defeat current methodologies.
I intend to combine high-throughput single molecule FRET (smFRET) experiments with computational modeling to achieve this goal. SmFRET will be used to derive individual building block structures as well as distances between these blocks on a molecule-to-molecule level. Computational modeling is used to fuse this information into a full atomistic model of the protein assembly.
The yeast ESCRT machinery is proposed as a model system to develop the new methodology. The ESCRT machinery is particularly important because of its role in HIV infections: HIV seizes control of the cells ESCRTs to get released from infected cells. The ESCRT assemblies size and flexibility lead to the fact that their assembled structure on membranes is largely unknown. Individual ESCRT proteins will be labeled by Cy3/Cy5. The ESCRT assembly will then be reconstructed on invaginated supported lipid bilayers and imaged via TIRF microscopy. FRET efficiencies will be recorded and the label-label distance determined. High-throughput biochemistry and labeling technology will allow us to generate > 100 distinct labeling sites, resulting in overdetermined structures. Stepwise photobleaching will reveal the stoichiometry within full assemblies. Alterations in FRET efficiency due to local contact formations within the assembly will reveal these local contacts. Based on the experimental data of the individual complexes, their copy number in the assembly and their local contacts, the full assembly will be determined computationally, based on replica exchange Monte Carlo simulations.";257860,8;257860,8;H2020-MSCA-IF-2014;MSCA-IF-GF;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195899;660150;MDR Tuberculosis;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolution and success of the multi-drug resistant M. tuberculosis SIT41 (LAM7-TUR) lineage;1/10/2015;30/09/2017;;"Mycobacterium tuberculosis (MTB) is the cause of tuberculosis (TB) in humans. Identification of the MTB lineage is of importance to tuberculosis control as it has shown that strain type may play a role in disease outcome, variation in vaccine efficacy and emergence of drug resistance. MTB strains of Beijing and Latin-American-Mediterranean (LAM) lineages were associated with hyper-transmissibility and drug resistance. In 2013 the European Center for Diseases Prevention and Control (ECDC) effectively lunched molecular surveillance of MDR TB at EU level. The typing of M. tuberculosis strains in Bulgaria confirmed strong association between MDR and SIT41 (LAM7-TUR) [SIT Spoligo International Type] MTB lineage. Statistically 97% of the TB patients infected with drug sensitive SIT41 MTB strain develop MDR tuberculosis. SIT41 is marker genotype for MDR TB. Urgent measures are needed to control and limit the expansion of the SIT41 lineage. We aim to promote personalised treatment of tuberculosis based on the genotype lineage of the TB pathogen and reducing the TB multidrug-resistant burden. The project has two objectives. First: Application of the next-generation sequencing data for genotyping of M. tuberculosis strains based on SNP data for tracking the origins, evolution and success of the SIT41 (LAM7-TUR) lineage, and second: Development of rapid screening methodology to identify the SIT41 (LAM7-TUR) genotype including mutation analysis to first and second line tuberculostatics drug resistance. Objectives will be achieved by fostering radically new technologies, by exploring novel ideas for MTB genotyping and improvement of the classical TB treatment scheme.
The project is timely because it has relevance to the Work Program Horizon 2020 focus area: Personalising health and care. For the first time we will promote personalised treatment associated with specific MTB genotype. The proposal is in line with the EU Health Strategy, ECDC, WHO and other TB control programs.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;Universit Paris-Sud;FR;;; 196014;660893;OCTANT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Modeling the chronology of deep ocean circulation changes during abrupt climate transitions;19/03/2016;18/03/2018;;"The deep ocean circulation affects climate and the global carbon cycle. A prerequisite for improving confidence in future climate projections is the accurate reproduction of past deep ocean circulation changes by models. However our understanding of such changes in terms of transport pathways and transit times is impeded by ambiguities in the chronology of ocean archives. This project aims at helping resolve such ambiguities by investigating to what extent the temporal evolution of the ocean circulation during abrupt climate transitions may be inferred from deep-sea sediment cores.
In this purpose we use the Earth system Model developed at Max-Planck Institute for Meteorology (MPI-ESM) fully coupled to an Ice Sheet Model (PISM). The coupled model naturally produces freshwater surges which exhibit the basic features of Heinrich events (massive discharges of icebergs to the ocean which occurred during the last glacial period).
We implement simple formulations for tracers which document ventilation and water mass distribution in deep ocean sediment cores (O18, C14, C13) in addition to age tracers. These age tracers allow distinguishing between the effects of varying conditions at the air-sea interface and water masses reorganization, while providing information on the relative contributions of specific water masses.
We then investigate the sequence of events in the deep ocean during Heinrich events, and the potential departures of proxy-based ages and transit times from the actual ventilation time scales. A coherent description of the temporal and geographical deep ocean ventilation evolution during abrupt climatic changes and associated uncertainties will then be obtained. Such a chronological framework will be beneficial to those investigating past climates by means of ocean archives or modeling studies.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195793;659449;CuPESS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Catchments under Pressure: Ecosystem Service Solutions;1/07/2015;30/06/2017;;"Catchments are under pressure from impacts on demand and supply and within these constraints water resource managers are challenged to meet multiple and often competing values. The ecosystem services (ES) approach has attracted policy interest as it connects natural capital and the ES flows it supports with human wellbeing. There exists a policy window to translate detailed case study assessment into workable solutions for catchment management in times of change in Europe and beyond. ES research to protect and foster sustainable management of natural resources and ecosystems and the multiple ES they supply fits within the Horizon 2020 programme on Societal Challenges.

The U.K. is emerging as a world leader in applying the ES approach to inform and improve natural capital planning and management in land and water resources management practice. The proposed interdisciplinary research would align with these initiatives to examine pragmatic planning solutions adopted in U.K. Water Framework Directive River Basin Districts. The objective of Catchments under Pressure: ES Solutions (CuPESS) is to understand how catchment managers are using the ES approach to provide local, adaptive and integrative management solutions in flood prone catchments and what are the opportunities and barriers to wider adoption.

This Individual Fellowship will provide opportunity for knowledge exchange, with the fellow returning to Europe and bringing her research expertise on the the ES approach and its use in water resources management in the U.S. and Australia. It will also allow the fellow to build on this research experience in an interdisciplinary research environment, to learn from a new context which will contribute to greater understanding of land-water interconnections, ES innovations and implementation strategies that work in practice. Lessons generated will be of wider relevance for flood risk management in other northern European countries and beyond.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LEEDS;UK;;; 195834;659684;FISHNAV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Following a path of breadcrumbs: How fish recognize landmarks during navigation;31/08/2015;30/08/2017;;"Reliable vision-based object recognition is of fundamental importance to a wide range of species; however, it can be difficult as the appearance of an object can vary greatly as a result of changes in viewpoint. Recognition during motion presents a particularly challenge as the appearance of an object continuously changes; a particular issue for animals that use landmarks to navigate. One recognition mechanism is to learn a two-dimensional snapshot of an object from a set viewpoint. The object can later be recognized once the appearance of the object matches the stored snapshot. Some animals reduce the number of required snapshots by employing active vision, where they follow identical routes between landmarks. For fish, the complexity of recognition is compounded by the fact that, unlike surface-bound animals, they can freely move vertically, which could potentially increase the number of approach views to an object. An alternate possibility is that fish have a view invariant recognition system and can generalize learned representations of objects so that they can be recognized from different viewing angles. However, high-level visual functions, such as object recognition, are associated with complex mammalian brain structures and may be impossible for animals lacking similar neural circuitry. Despite these problems, we know that fish are capable of navigating efficiently using landmarks. The goal of this project is to investigate how fish recognize visual landmarks during navigation and to determine how they cope with self-orientation related changes in the appearance of objects during motion. Using behavioural experiments, we will test whether fish have view invariant recognition and/or if they employ active vision during navigation. The proposed project will further our knowledge of how fish perceive their visual environment as well as inform us about how conserved the mechanisms of object recognition are from an evolutionary perspective.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195948;660448;KCs and Gut Antigens;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens;1/05/2015;30/04/2017;;The liver is constantly exposed to intestinal material via portal blood circulation and thus it has long been implicated in the modulation of systemic immune responses to intestinal antigens. Despite this, the precise cells involved and the molecular mechanisms at play are largely unknown. Liver resident macrophages termed Kupffer cells (KCs) are ideally located within the blood stream of the liver sinusoids to encounter intestinal antigens. We hypothesise that KCs acquire intestinal antigens and subsequently modulate the immune response to these. Despite indications that KCs are involved, the lack of KC-specific tools has significantly hampered the study of these cells and to date their physiological role in modulating immune responses to intestinal antigens remains unclear. Here we propose to utilize novel and innovative tools including KC-specific knock-in (KI) mice generated by the host lab to specifically examine the role of KCs in antigen acquisition, presentation and determination of T cell fate. To our knowledge these tools represent the first of their kind and place us in a unique position to specifically examine the role of KCs in regulating the immune response to intestinal antigens. By combining murine modeling with analysis of human tissues in collaboration with the University Hospital, this project will greatly advance our understanding of the role of KCs and potentially uncover new therapeutic strategies in the prevention and/or treatment of disorders where the systemic immune response to intestinal antigens is dysregulated such as food allergies and inflammatory bowel diseases (IBDs).;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;VIB;BE;;; 195862;659932;miRNAs in TH2 cells;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role of extracellular miRNAs in T cell development, TH2 cell differentiation and TH2 cell-mediated effector function;1/08/2015;31/07/2017;;"It is estimated that more than 200 million Europeans suffer from at least one type of allergy. This condition is elicited by an hyper-activated type-2 inflammatory response coordinated by T helper (TH)-2 cells. In spite a good insight into the molecular mechanisms that triggers TH2 cells activation, the lack in understanding their post-transcriptional regulation is hampering the access to new potential therapeutic targets to curtail the allergy epidemic.
Micro-RNA (miRNAs) are regulatory molecules essential for life, which play a fundamental role in shaping cellular functions via post-transcriptional repression of the cellular transcriptome. Though previously considered to operate exclusively inside the parent cell, it is now acknowledged that miRNAs can exit cellular boundaries and control transcription in bystander cells. We recently reported that regulatory T (TREG) cells secret specific miRNAs to repress TH1 cell-mediated immunopathology, and ameliorate a mouse model of autoimmune disease.
In this proposal, we will address the role of extracellular miRNAs for the normal T cell development and during allergic inflammation of the airways. To this end, we produced a novel animal model that allows - for the first time - to selectively ablate the activity of extracellular miRNAs in T cells. We will use biochemical, RNA-sequencing and bioinformatics analysis to identify the molecular mechanisms for miRNAs sorting to exocytosis and to identify the miRNAs transferred to and from TH2 cells. This proposal will significantly expand our understanding of transferred miRNAs in the contest of health and disease, and will uncover novel cellular pathways to exploit as therapeutic targets.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE FRANCIS CRICK INSTITUTE LIMITED;UK;MEDICAL RESEARCH COUNCIL;UK; 195900;660152;depreg;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Antidepressants during pregnancy: underlying mechanisms associated with neurodevelopmental outcome;1/06/2015;31/05/2017;;"Depressive symptoms frequently occur during pregnancy and may have a tremendous impact on the developing child. Unfortunately, pharmacological antidepressant treatments during pregnancy can negatively impact behavioral development and health of the offspring. In humans it is difficult to discern between the effects of the drug and the effects of the depression itself, therefore it is unclear whether children exposed to antidepressants in utero are at increased risk, and if so, what the underlying molecular mechanisms are that may point to potential solutions.

My overall aim is to identify molecular mechanisms and behavioral alterations in the offspring due to antenatal depression, antidepressant treatment during pregnancy, and their combination. To achieve this goal I will use an advanced rat model for depression to allow an experimental approach. I will identify the effects of antenatal depression, antidepressant treatment during pregnancy, and their combination on: (1) behavior of the offspring, (2) gene expression patterns with micro-array in the fetal brain, and (3) epigenetic profile of genes from the micro-array in adult brain and blood plasma.

So far, Genome Wide Association Studies have not yielded new targets for the treatment of depressed (pregnant) patients.
The outcome of this study will not only advance our knowledge on genes underlying the alterations found in brain and blood of the offspring due to antenatal depression, antidepressant treatment and their combination, but will also reveal early biomarkers as the epigenetic profile for the altered genes are studied. Ultimately, the results of this project will be beneficial for human health as it will open up new avenues for biomedical research and therapeutic applications.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;RIJKSUNIVERSITEIT GRONINGEN;NL;;; 195670;658850;Als-on-a-chip;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A tissue-on-a-chip platform for systems-level studies of ALS pathology and drug screening;30/09/2015;29/09/2017;;"Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, which affects approximately 2 per 100000 people. Currently, there is no ALS treatment. The main tool for preclinical ALS studies is the hSOD1G93A mouse. However, despite promising results in this model, all candidate drugs failed in clinical trials. These failures have been partly attributed to differences in the physiology of human and mice nerve cells, and the inability of the established drug design approach to block ALS pathology. There is urgent need for new tools that will complement this mouse model, improve understanding of ALS pathology, and suggest better leads for clinical trials.
The objective of the proposed study is to develop a tissue-on-a-chip platform for systems-level studies of ALS pathology and drug screening. The system is built around a novel thin porous scaffold, where systems of normal or ALS-type mouse and human motor neurons will be cultured inside an appropriate 3D ECM analog, and their response (intracellular signaling, cell processes, cell-cell communication) to stimuli panels in the presence of drugs will be quantified via high-throughput proteomics and fluorescent imaging. Acquired data will be interpreted by modifications of state-of-the-art system biology tools.
The outcomes of the proposed research can lead to new ALS treatments by identifying new drug targets (via mechanistic description of ALS pathology), and by developing better ways to evaluate candidate drugs before clinical trials (via comparing drug response in human and mouse cells). Results can be translated to other neurodegenerative diseases. Finally, the proposal offers an opportunity to a promising researcher to relocate from MIT to Greece, collaborate with a leading neurobiology lab in a world-class environment and a systems pharmacology SME, and translate his research via two startup companies. The host envisions the opportunity for a tenure-track faculty position for the experienced researcher.";164653,2;164653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;;; 195884;660067;COLDmicroWAVE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Energy innovative food process for production of high quality frozen foods;1/05/2015;30/04/2017;;COLDWAVE aims to improve the research skills of Epameinondas Xanthakis by developing an innovative environmentally sustainable process for blanching and freezing vegetables with improved textural and nutritional quality at SP -Technical Research Institute of Sweden. The study which will be carried out will involve the use of microwave electromagnetic irradiation (MW) for blanching and freezing of vegetables. COLDWAVE will develop tailored equipment for MW blanching of vegetables that has very high energy efficiency and no water consumption. Furthermore, this project will develop innovative pathways in freezing to improve the quality of frozen vegetables by exploring, in a new context, previous results acquired by the fellow. The developed process will lead to improved quality characteristics compared to the conventional freezing. During this extensive study the fellow will gain valuable multidisciplinary experience and new theoretical and practical skills in the areas of heat transfer modelling, energy accounting methods, food nutrition and quality measurements as well as life cycle assessment methods. The integrated proposed study will give the fellow the opportunity to develop further knowledge on development of innovative processes having industrial importance and finally become a real specialist in the microwave assisted food blanching and freezing. The candidate will also learn to conduct research, to manage projects, communicate results effectively, commercialise research, as well as an in-depth education in development of innovative processes which will contribute for an open mind to innovation and more successfully realisation of research ideas into commercial reality.;173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;RISE RESEARCH INSTITUTES OF SWEDEN AB;SE;;; 195816;659595;MCMQCT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Multi-functional Computational Microscopy for Quantitative Cell Tracking;1/08/2015;31/07/2018;;Quantitative assessment of cellular phenotypes can result from various processes such as genetic manipulation, gene silencing, drug application or environmental changes. In many biological processes evident development of phenotypes often requires a long-term study of the sample, which can capture events at high-resolution and high frame rates. The essential working tool for this kind of studies is the optical microscope, which is essentially limited by a small field of view of the sample in two-dimensional (2D) environment, unsuitable for the quantitative assessment of cells in a more natural environment, in which they develop and evolve within complex communities. For this task, I purpose a novel platform based on a holographic on-chip microscopy which represents a new generation of computational microscopes, by integrating transformative technologies, which will ultimately enable five-dimensional, photodamage optimized at diffraction limited resolution, quantitative cell tracking. We believe that these functionalities and the platform's cost effectiveness will enable next generation high-throughput scientific research on the influence of drugs, genome modification and environmental changes, developing new models for cell locomotion, such as viral plague growth assays performed in hospitals and clinics, detection of parasites and bacteria in food/water and for education purposes, including in developing countries.;263385;263385;H2020-MSCA-IF-2014;MSCA-IF-GF;BAR ILAN UNIVERSITY;IL;;; 195841;659747;HCAPT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High Current All Printed Transistors;1/05/2015;30/04/2017;;"The fast evolution of printed electronics, with the photovoltaic technology in primis, is requiring the presence of a valid transistor alternative to the traditional one. The realization of a high current roll-to-roll transistor will interconnect all the different technologies so far developed with this low cost and high throughput method. Our aim is to develop a roll-to-roll transistor capable to of modulate modulating the current to levels that where has not been achieved so far. The fabrication of the transistor will be done considering the lowest environmental impact possible, and containing energy consumption with a temperature below 150 C. This high current (~mA) transistor will be able to support and assist other technologies and will also be the base for logics and sensing application.
The optical studies on the organic material will result in a more controllable production process that for the first time will relate polymer crystallinity directly with an optical characterization technique. The realization of such kind of measurements is not trivial, but will give information on polymer nanoscale structures never investigated before. To do so this technique uses femtosecond pulse in subdiffraction-limited area. This will disclose an unprecedented tool to control the polymer morphology as soon as it is deposited, with enormous consequences in performance control and optimization.
The realization of samples and the study of real cases will produce important information regarding this new technology and its real life applications. In addition, life-time and stability studies can be performed. Then the objective of minimizing the environmental impact of the technology life time cycle will be more realistic. These kinds of studies are also important to explain science to the society and to give a technology preview to industries.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DANMARKS TEKNISKE UNIVERSITET;DK;;; 195887;660077;FUNC NGS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deep screening of proteins with a next generation sequencing platform;1/08/2015;31/07/2017;;Next generation sequencing (NGS) has become an indispensable tool for system biology and has recently been adopted in protein engineering science as well. This proposal describes the development of a highly generalizable technique, termed FUNC-NGS, which links in situ functional information of protein activity with the function-determining DNA sequence in a massively parallel manner opening exciting possibilities, e.g., in drug discovery. In this method a cell-free display platform is combined with NGS by modifying protein display units to contain unique homing oligonucleotide sequences. These units are subsequently targeted to bind monoclonal DNA clusters in the flow cell of an Illumina sequencer by complementary DNA hybridization. FUNC-NGS is readily compatible with a paired-end sequencing programme on the Illumina platform and the number of screening units is only limited by the number of DNA clusters on the flow cell. As the first application challenge, a new variant of a modified bacterial adhesin, Spycatcher, will be created with an altered specificity for synthetic biology applications. Novel Spycatcher-SpyTag pairs are intensively desired but their creation is demanding. Solving this problem will be a perfect showcase for this radically novel deep screening technology. At the mature stage FUNC-NGS will be a transformative platform in therapeutic protein development, functional genomics and personalized medicine. The proposed work will be carried out at Dr. Hollfelders laboratory at the University of Cambridge with a short secondment at Medimmune. Hollfelder group has developed SNAP display, which is a FUNC-NGS-compatible in vitro protein display system. Furthermore, the University hosts excellent facilities for NGS sequencing and experienced bioinformatics support is available. The planned research programme synergistically combines my expertise in molecular biology method development with the hosts expertise in cell-free display and IVC-techniques.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195770;659317;PALADIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Positron Annihilation Detection Beyond the Limits;1/09/2015;31/08/2017;;"Given the growth and aging of the world population, innovative solutions for sustainable energy and health are needed. Novel technologies play an enabling role in the realization of such solutions. Better devices for the detection of annihilation quanta resulting from positron annihilation are an example. In material science these detectors are needed for research on renewable energies and innovative energy storage using Positron Annihilation Lifetime Spectroscopy (PALS). In medicine they are required for diagnosis, staging, and treatment monitoring of diseases using Time-of-Flight Positron Emission Tomography (TOF-PET).
In both fields time resolution is a key parameter. Sub-100 picosecond resolution is needed but not yet available. Improvement of time resolution, however, must not deteriorate other performance parameters. This project aims to overcome present physical limits. Monolithic scintillation crystals will be read out with digital photon counter (DPC) arrays coupled to each of its surfaces. Innovative data processing methods will be developed to eliminate the influence of scintillation photon propagation, currently the major bottleneck in large scintillation crystals that are nevertheless needed for high detection efficiency. We aim at coincidence resolving times (CRT) < 100ps FWHM, 10% energy resolution, 1 mm isotropic spatial resolution, and 90% detection efficiency.
The detector will be incorporated in a PALS setup. After the performance has been characterized, it will be used for TU Delfts materials research on renewable energy. The detector characterization will also serve as a proof-of-concept for application in clinical TOF-PET devices. The results are furthermore expected to be of relevance to fields such as high-energy physics.
To investigate options for further improvement of the already unprecedented time resolution, studies will be done towards exploiting the Cherenkov-effect in a detector based on a hybrid Cherenkov/scintillation material.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITEIT DELFT;NL;;; 195821;659643;URBANEPIGENETICS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress;1/04/2015;31/03/2017;;The impact of urbanisation on wildlife is of increasing global concern. It is well known that exposure to urban environmental stressors increases oxidative stress. More recently, exposure to pollutants has been shown to directly modify the epigenome, via DNA methylation, in humans. Oxidative stress may be a key mechanism mediating epigenetic modifications in response to pollutant exposure and thereby influencing development, disease resistance and ageing. This multidisciplinary project outlines the first study to date of the epigenetic basis of early-life effects in a wild bird exposed to urban environmental stress. Early-life stress exposure can have profound effects on phenotypic development and long-term fitness. Epigenetic mechanisms are influenced by environmental cues during development and therefore may mechanistically link developmental conditions with later-life performance. Using urban and rural populations of birds, we will perform experimental studies in the field and lab to examine whether increased oxidative stress during development modifies patterns of global and gene-specific DNA methylation and thereby alters genome stability (via DNA damage and telomere attrition) and expression of antioxidant genes. To achieve this, we propose a new framework to explain how the modification of DNA methylation and telomere length may be linked and decoupled by the direct and indirect effects of oxidative stress at different stages during development. Pilot data support this framework. This will enable us to disentangle the mechanistic relationships between exposure to urban stressors, oxidative stress, DNA methylation and telomere dynamics during development and the consequences for growth and survival in an altricial bird species. The project has implications for multiple EU policies and H2020 focus areas. By combining the researchers existing expertise with new skills and opportunities, the project will enhance career prospects and advance the research field.;185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUNDS UNIVERSITET;SE;;; 195777;659369;INTERMESTIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Anglo-American Relations and the 'Intermestic', 1977-81: A Case Study of the Influence of National Parliaments on Foreign Policy;1/02/2016;31/01/2019;;"This project is the first in-depth examination of the impact made by the U.S. Congress and the British Parliament on Anglo-American relations, and the 'intermestic' dimension of foreign policy. Using the relationship between the Carter administration and the Callaghan and Thatcher governments as case study, I will demonstrate how the transatlantic partnership was shaped by lobbyists in the House of Representatives, the Senate, and Westminster. The wider objective is to provide a new framework for understanding (a) the role played by national parliaments on foreign policy decisions; and (b) the ways in which parliaments and parliamentarians can shape bilateral ties, and foreign relations generally. Undertaking expert training-through-research at Cornell and Nottingham Universities, the project will correct a major problem in the methodology of diplomatic history, where the impact of legislative institutions and parliamentarians on government policymaking continues to be under-studied or overlooked. On completion of the fellowship, I will have significantly advanced our knowledge of Cold War history and Anglo-American relations, explained the importance of the intermestic for how we approach the study of foreign policy, and demonstrate how parliaments shape bilateral relations in ways which are never considered by historians.";251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE UNIVERSITY OF NOTTINGHAM;UK;;; 195844;659765;Consciousness online;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A real-time, online study of the functions of consciousness;1/06/2015;31/05/2017;;"What if any is the functional significance of conscious awareness? Even after centuries of theoretical effort and decades of experimental research the answer to this question is still unknown, partly due to conceptual and methodological limitations of previous approaches. Here, I propose a novel approach that addresses this fundamental psychological question by capitalizing on neuroscientific development. Namely, I plan to construct a real-time system that analyses intracranial and EEG data and presents it to the subject as sensory feedback. The system will be trained to detect unconscious neural events as they unfold, and present them to the subject online, hereby turning these unconscious events into consciously accessible ones. The effect of this manipulation on performance can then be measured, revealing the unique contribution of consciousness to the function of interest. This proposal includes four experiments that will focus on consciousness involvement in volitional control, using the Binocular Rivalry paradigm (BR). In BR, subjects' perception alternates between two stimuli presented simultaneously but separately to each eye. Previous studies showed that subjects can control these alternations, but to a limited extent; unconscious processes (e.g., stimuli habituation) lead to perceptual alternations at unpredictable times. Here, I plan to ask subjects to try and exert such volitional control over rivalry while being presented with real-time sensory feedback about the unconscious processes that lead to upcoming alternations. I predict that such feedback about the otherwise unconscious neural activity will enhance subjects' ability to control the rivalry. This promises to yield new insights about the widely debated role of consciousness in volitional control while paving the way to a systematic, innovative investigation of the possible functions of consciousness.";182509,2;182509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TEL AVIV UNIVERSITY;IL;;; 195998;660773;MINERVA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Micro-RNAs of neutrophils in renal ANCA-associated vasculitis;1/04/2016;31/03/2018;;Activation of neutrophils by ANCA (Anti-Neutrophil Cytoplasm Antibodies) and subsequent endothelial cell (EC) damage is the main feature of ANCA-associated vasculitis (AAV). There is no specific treatment for AAV to date and 25% of patients evolve towards end-stage renal disease requiring dialysis and renal transplantation. While accumulating data indicate that miRNAs control major biological responses in various cell types including EC and neutrophils and are involved in the pathophysiology of several diseases, their role in AAV has been virtually unexplored. In addition, recent studies have shown that ANCA-activated neutrophils can induce EC damage through the release of microparticles, but while many studies have revealed a critical role for miRNAs secreted within microparticles in intracellular crosstalks, there is no data so far on the role of miRNAs in this process. Here, we propose to identify miRNAs deregulated in neutrophils exposed to ANCA and released in microparticles that promote EC damage in AAV. These miRNAs will be identified using TaqMan Low Density Arrays in ANCA-stimulated neutrophils in vitro and in the microparticles they release, as well as in neutrophils from patients with AAV. To assess whether these miRNAs could be used as biomarkers, their expression will also be analyzed in plasma and urine samples from AAV patients, and correlated with severity and outcome of the disease. The transfer of neutrophil-secreted miRNAs to EC will be assessed in vitro, and the function of these miRNAs in the regulation of EC responses (activation, angiogenesis) will be studied in various functional assays. While miRNAs are emerging as new therapeutic tools for several diseases, this translational study will provide the first data regarding the expression and function of neutrophil miRNAs in AAV and may therefore pave the way for novel promising miRNA-based therapeutic options in these patients.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 195819;659625;PATRIMONiT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;PATRIMONiT. From Cheap Print to Rare Ephemera: 16th-Century Italian 'Popular' Books at the British Library;1/02/2016;31/01/2018;;"Large quantities of 16th-Century Italian popular books the books read or listened to by everyone during the Early Modern Period, printed with poor quality material and having usually a short life expectancy , sometime after the 16th century found their way to the UK to join the largest single collection of Italian 16th-century books in the world, that is the British Library (BL). This library preserves today a substantial number of early Italian editions which do not survive in any Italian library and are still not adequately recorded.
The objectives of the PATRIMONiT project are both bibliographical and historical: 1) to survey all the 16th Italian popular books now at the BL which do not survive in any Italian library; 2) to define new rules for cataloguing 16th popular books and catalogue approx. 250 items in the PATRIMONiT database, entering the data in EDIT16 and in the CERL Thesaurus; 3) to study the edition history of these books using archival sources, that is to examine the historical circumstances related to their survival and international circulation with a new methodology.
Carnelos proposes to demonstrate that this ephemeral material is really important in reconstructing the socio-cultural history of a country. Specifically, her aim is to understand when and why popular books underwent a change in their perceived value, from books to be used and reused to books that were considered at once disposable and worthy of collection, and how time and space, politics and cultural policies influenced this change.
Supported by three centres of excellence (the Consortium of European Research Libraries or CERL, the BL and the Istituto Centrale per il catalogo unico delle biblioteche italiane e per le informazioni bibliografiche or ICCU), the PATRIMONiT project combines the more recent developments in three main disciplines (Library Science, History and ICT), to tackle historical questions which cannot be approached and successfully solved individually.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Consortium of European Research Libraries;UK;;; 195847;659776;FiBRO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fibroblasts in the Biology of Rectal Cancer Progression;1/04/2016;31/03/2018;;"Although the therapeutic strategies adopted in the last years for the clinical management of patients with rectal cancer have improved patients quality of life, tumor relapse still constitutes to be a factor that determines patient survival. These patients, usually treated with chemo-radiotherapy (CRT), often develop a CRT-induced fibrosis, which is characterized by an overgrowth of fibroblasts at tumor-treated areas. The importance of tumor stroma for the development, progression and invasion of cancer is increasingly gaining weight, however, the biological basis of fibrosis, as well as the consequences that it has in terms of therapy resistance and tumor relapse remain unknown. The major objective of this proposal is to understand the effect of CRT on fibroblasts and its consequences on tumor relapse and formation of distant metastasis. To reach this, we propose a multidisciplinary approach that combines the analysis of unique patient-derived biological samples using innovative and advanced techniques in molecular and cell biology. More specifically, using a proteomic approach and primary cultures of fibroblasts derived from rectal tumors taken before and after CRT from the same patient, we will determine the effect of CRT on the molecular alterations in fibroblasts. Then, using 3D in vitro models we will determine if CRT-derived fibroblasts play a role in therapy resistance, proliferation and invasion of cancer cells, while ortothopic mouse models will be used to test if CRT-derived fibroblasts can trigger rectal cancer progression and metastasis. Finally, using previously collected clinical data of rectal cancer patients we will analyze if tumor relapse is related to the appearance of fibrosis and, if it has a positive or negative prognosis value
Altogether, the results expected from this project will improve basic biological knowledge of fibrosis-development, and will provide with new clinical tools to improve patient welfare.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT CURIE;FR;;; 195885;660086;BayesianHumanCortex;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Bayesian computations in the human neocortex: deciphering the neuronal mechanisms of perceptual and syntactic inferences.;1/08/2015;31/07/2018;;The diversity of human cognitive abilities contrasts with the homogeneity of its neural bases. Indeed, perception, decision and language processes largely rely on a common neuronal structure the neocortex whose functioning remains remarkably poorly understood. Recent theories suggest that the six layers of the neocortical microcircuit are specifically interconnected to perform generic computations, thanks to a Bayesian hierarchical combination of top-down expectations (priors) and bottom-up sensory information (likelihoods). However, recording each cortical layer is technically challenging. Mainly limited to animal electrophysiology, the rare empirical investigations of neocortical operations have been incapable of tackling human-specific cognitive abilities, such as syntax processing. Capitalizing on recent advances in human electrophysiology, I will address these challenges by testing whether the elements of Bayesian computations are implemented by 1) distinct cortical layers (e.g. priors in layers 5/6) or, alternatively, 2) distinct neuronal oscillations (e.g. priors in the alpha/beta band). I will then assess whether these neuronal computations form the elementary components of syntax processing. To characterize the exchange of information within and between cortical regions, I will combine whole-brain magnetoencephalography of with invasive electrocorticography and intra-laminar recordings, acquired from patients implanted for clinical purposes. This project, at the intersection of neuroscience, computational theory and linguistics will set the foundations for a mechanistic investigation of human cognition at an unprecedented level of detail, and will therefore allow me to start a competitive scientific career as an independent researcher. Ultimately, this innovative framework will help us understand the building blocks of human cognition, and the way neocortical dysfunctions lead to complex mental disorders such as schizophrenia.;257860,8;257860,8;H2020-MSCA-IF-2014;MSCA-IF-GF;STIFTUNG FRANKFURT INSTITUTE FOR ADVANCED STUDIES;DE;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE; 195869;659994;MatrixMacrophages;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Matrix degrading macrophages in cancer growth and invasion;1/07/2015;30/06/2017;;"Solid tumors consist of malignant cancer cells in constant interaction with the extracellular matrix and different types of non-malignant cells. Notably, these cells include macrophages which, during cancer progression, take part in an extensive degradation of the extracellular matrix. This process leads to destruction of the normal tissue and facilitates metastatic spread.
It is now evident that tumor-infiltrating macrophages have a strong impact on cancer progression and this has led to the suggestion that therapeutic targeting of these cells could form the basis of a powerful new type of cancer treatment. However, there is a strong need for increased understanding of the function of these tumor-associated macrophages in order to optimize the development of such new therapy. Most importantly, different subtypes of macrophages exist, but how these subtypes affect cancer progression and whether they contribute to the cancer-associated extracellular matrix degradation is very incompletely understood.
In this proposed project I aim to elucidate the exact role of different subtypes of macrophages for cancer progression and for the accompanying extracellular matrix degradation. By using several experimental state-of-the-art techniques, I will directly examine the effect of different subtypes of macrophages on cancer growth and invasion. These techniques include two-photon microscopy, flow cytometry based cell sorting, next-generation sequencing, cell biology assays, and mouse genetic engineering. In particular, I am currently developing transgenic mice that allow both the visualization of specific macrophage subsets using fluorescence microscopy and the specific depletion of these cell populations. When combined with tumor models, these mice will provide unique insight about the importance of the cell types in question.
The study will add significantly to our knowledge about macrophages in cancer biology and aid in the development of new cancer therapy strategies.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KOBENHAVNS UNIVERSITET;DK;;; 195755;659241;SPEA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Socrates and Plato on Epistemic Authority;1/09/2015;31/08/2018;;It often happens that we accept as true what other people tell us, and by doing so, we acquire knowledge about the world. We trust each other, and we often grant teachers and experts authority over our beliefs. The inter-subjective nature of belief formation has recently moved into the very center of epistemology. However, it is rarely mentioned that the reflection on the role of other people in our knowledge-acquisition has a distinguished historical pedigree, one that still deeply affects the way think about these issues. In particular, the Greek philosophers treatment of the notions of authority, trust, and disagreement has exerted strong influence on the subsequent history of philosophy. Up to now, however, there has been no systematic study of this important aspect of Greek thought. This project, Socrates and Plato on Epistemic Authority, focuses on the role attributed to what philosophers call epistemic authority (i.e. authority over belief) in knowledge acquisition and belief formation in the classical era of Ancient Greek philosophy (esp. in Socrates and Plato). Thus, the project aims to improve the understanding of Greek epistemology and to offer a historical background and an independent contribution to a central epistemological topic.;228421,8;228421,8;H2020-MSCA-IF-2014;MSCA-IF-GF;TARTU ULIKOOL;EE;;; 195826;659660;Transpacific;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Assembling the Transpacific: Indigenous Curatorial Practices, Material Cultures and Source Communities;1/05/2015;30/04/2017;;Since the 18th century, the discipline of anthropology has emerged through scientific exploration and colonial expansion beyond Europe, as well as the establishment of ethnographic collections and museums in Europe. Ethnographic objects thus influenced academic and public understandings of other cultural-geographic spaces. The often resulting Eurocentric projection of anthropological imaginations has come under severe pressure, as e.g. seen in recent indigenous repatriation claims against the Humboldtforum in Germany. Postcolonial renegotiations in former European colonies, such as many South Pacific nations, have caused dramatic changes to anthropological practices through indigenous curatorial practices. Ethnographic objects in European museums, however, remain largely disconnected from the cultural environments of their indigenous producers and the indigenous sources of anthropological knowledge. This project addresses this deficit through a multi-sited, collaborative ethnographic investigation of contemporary indigenous curatorial practices in two South Pacific museums located in Polynesia (Museum of New Zealand Te Papa Tongarewa and Museo Rapa Nui, Easter Island, Chile). The project generates historically informed, ethnographic insights into the figure of the curator as an agent of indigenous knowledge production and community engagement across the Pacific. In doing so, the project presents indigenous perspectives that reframe the anthropological curatorship of Pacific collections in, and the production of public understandings through, ethnographic museums in Europe. The applicant has a track record of successful collaborations with indigenous scholars and is currently conducting a study of the Bishop Museum Hawaii, which is also located in Polynesia. The IF project advances a cross-cultural anthropology overcoming scientific Eurocentrism, and provides ethnographic museums in Europe with a roadmap for renegotiating the curation of indigenous objects.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195778;659371;nAChR PAM-to-gate;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gating mechanism and pharmacological modulation of nicotinic acetylcholine receptors;1/04/2015;31/03/2017;;Pentameric ligand-gated ion channels (pLGICs), including nicotinic acetylcholine, 5HT3, glycine, and GABAA receptors, are membrane proteins specialized in the communication between neurons. These neurotransmitter receptors are the target of general anaesthetics, anxiolytics, alcohols and nicotine. In particular, enhancing the activity of neuronal nicotinic receptors holds promises in the treatment of pathologies including nicotine addiction, schizophrenia and Alzheimers disease. The current project aims at deciphering the molecular and pharmacological determinants of positive allosteric modulators of neuronal nicotinic receptors. We will over-express and purify these proteins, study their pharmacology through electrophysiology in cell lines and planar lipid bilayer, and surface plasmon resonance binding studies. Our study will provide insights into the molecular mechanisms of allosteric regulation, paving the way for the rational design of allosteric modulators with therapeutic potential.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;INSTITUT PASTEUR;FR;;; 195933;660363;SynBiol-DynHet;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Diversity in Synthetic Biological Systems;1/09/2015;31/08/2017;;"One key problem in the investigation of living systems is their complexity. Synthetic biologists can create artificially designed biological systems, whose design reduces the complexity, and can thus address simplified and specific questions. Theoretical investigations of these systems help to understand these questions, for example by evaluating whether a simple model already predicts the features shown in experiments.

This proposal provides a step towards understanding living systems by theoretically studying diversity in microbial populations. The aim is to investigate both spatial diversity, such as barriers, as well as agents with different traits within a population. This will be done with the goal of answering important ecological as well as microbiological questions.
In terms of the ecology, this work will address how spatial barriers, or the presence of diverse agents, can influence the formation of biodiversity and cooperation. In its engagement with microbiology, it will investigate a microbial population's reactions to randomly distributed antibiotic drugs, and the ability to tolerate these antibiotics.
With the development of new experimental procedures that allow closer investigations of both these issues, an improved
theoretical description is now required alongside such advances.

I will investigate all questions in close collaboration with synthetic biology experiments. This project will allow me to combine my background in the theory of condensed matter and chemistry to work on living systems research, before obtaining an independent researcher position in the field of biological physics.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195655;658832;SOLLAY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Soft Chemical Control of the Physical Properties of Layered Solids;26/07/2016;25/07/2018;;"This research programme is fundamental solid state chemistry at the boundary with condensed matter physics. It will discover new transition metal compounds with layered crystal structures and aims to put them on the world stage by exploiting the compositional tunability which is intrinsic to non-molecular systems. The discovery and chemical rationalisation of new composition-structure-property relationships is anticipated to lead eventually to future industrial developments in applications as wide ranging as superconductors, thermoelectric materials, magnetic materials, batteries and heterogeneous catalysis. Parallel to the research, the fellows outreach activities will centre on highlighting these synthetic minerals to the general public in a permanent exhibit. The host group and the fellow bring complementary expertise to the project and the career development of the fellow will be through the research and outreach and also in the development of collaborations with Oxford Physics, and the world-leading international facilities for neutron and synchrotron X-ray science at the local Harwell campus and in Grenoble.

The project will develop science and the fellow through the pursuit of ground-breaking and adventurous research directions at one of the forefronts of solid state chemistry. It will be carried out in an internationally leading group in a chemistry department in the top handful in Europe.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195762;659256;NEURINFDNA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neuronal DNA double strand breaks as novel epigenetic actors: roles in cognition, health and neuro-inflammatory diseases;4/01/2016;3/01/2018;;"Cognitive deficits are manifested several years prior detecting any neuronal loss in neurodegenerative diseases or during persistent infections of the central nervous system (CNS). Accumulating evidence show that epigenetic alterations contribute to neuronal dysfunction, as they cause durable changes of the chromatin structure that affect gene expression. In this context, DNA double-strand breaks (DSBs) are now emerging as central regulators of neuronal epigenetics.
My recent findings opened innovative perspectives of research. I showed that DSBs are not always associated with neuronal apoptosis, but rather constitute novel epigenetic signals that contribute to cognitive processes. To date, the role of DSBs in pathogen persistence and the mechanisms whereby DSBs affect neuronal function in the course of an infection are totally unknown. Here, we postulate that perturbations in sensing, production and/or repair of DSBs may underlie the behavioral impairment that is observed in many CNS infectious diseases.
Persistent neuronal viral infections, such as Bornavirus or Herpesviruses alter neuronal function, sometimes without overt immune response. The underlying mechanisms may result from episomal persistence of the viral genome in interaction with neuronal chromatin, thereby hijacking the chromatin remodeling system of the host cell, or from the secretion of proinflammatory cytokines. Parasites such as Toxoplasma also persist in the CNS and cause behavioral impairment. Their long-lasting impact on neuronal function may involve the modulation of the epigenome.
Here, we propose to analyze the role of DSBs in cognitive alterations that accompany neurological infectious diseases. In particular, we will: 1) characterize the role of pathogens and the associated immune response to neuronal localization of DSBs during CNS infections; 2) analyze which mechanisms of neuronal DSBs generation, detection and repair contribute to cognitive impairments in CNS infections.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 195801;659489;MetalCell;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transition-Metal Mediated Chemistry in Cells;1/12/2015;30/11/2017;;"Over the past decade, metals which were previously restricted to conventional organic synthesis have begun to be used in an increasing number of biological settings. This has been dominated by copper mediated catalysis of the azide-alkyne Huisgen cycloaddition (1,3-dipolar addition) chemistry (the well know click reaction) but other, less toxic, metals such as palladium are now beginning to establish themselves in the chemical biology/ chemical medicine arenas. In this proposal, building on chemistry from the Bradley group (see Nature Chemistry, 2011 and Nature Communication, 2014) the potential of palladium mediated chemistry in living systems will be exploited. This will cover three main avenues of exploration: (i). The fabrication of active palladium catalysts conjugated to antibodies and small targeting peptides; (ii) Development of assays to allow the activity of the active catalysts to be determined both in vitro and inside cells and (iii). The application of these active palladium catalysts enable the conjugation of two drug halves to allow the in situ synthesis (inside cells) of active anticancer drugs. This fellowship will bring together chemistry, biology and medicine, with potential longer-term biomedical applications with the training of the applicant in learning new chemistry and biological technique. This will be tied into an improvement of my independent thinking and leadership skills, gain of experience in writing grants and research articles and peer-reviewing and working in a multidisciplinary manner, with major opportunities to broaden my soft-skills set.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195983;660668;ACT against AMR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Abyssomicin C Truncated derivatives against Antimicrobial Resistance;1/05/2015;30/04/2017;;"This project aims to offer a solid solution to the dwindling effectiveness of antibiotics against infectious diseases caused by the development of antimicrobial resistant (AMR) bacteria. The core of this proposal is to implement an innovative synthesis-oriented strategy to access truncated derivatives of abyssomicin C, a natural product that has shown especially promising antimicrobial activity against the most common strains of antimicrobial resistant bacteria. The multiple routes proposed for the synthesis of the truncated core scaffold are short, robust and amenable for many different variations. This will open up for the possibility to easily synthesise a library of differently adorned abyssomicin C truncated analogues whose antimicrobial activity will be evaluated. Structure activity relationship (SAR) studies aided by computational modeling will be used as an integrated action in the identification of new potent antimicrobial agents.
The complementary expertise of the applicant, the host laboratories and the leading experts that will collaborate within this project will be crucial for the realization of all aspects of this multifaceted project. The achievement of the project goals will have a deep impact not only in the scientific community but also on the healthcare systems in Europe and globally.
This EF postdoctoral training proposal will represent a unique opportunity to the candidate to expand his scientific network in both the academia and the industry, greatly broaden his spheres of action, strengthening his professional maturity.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 195806;659529;EastAsiaAerosol;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sources and atmospheric processing of carbonaceous aerosol in East Asia;1/05/2015;30/04/2017;;"High loading of carbonaceous aerosols from residential combustion of coal and wood fuels, traffic, industry, and biomass burning pollute the air of East Asia. The resulting Atmospheric Brown Clouds (ABC) are in wintertime warming the atmosphere yet dimming the surface in this vast region with severe impact on the climate, food and water security as well as air quality. Although these short-lived climate pollutant (SLCP) aerosols attract large interests across the science-policy interface, efficient mitigation actions are hampered by the limited understanding of the relative contributions of different sources of combustion-derived carbonaceous aerosols and of their subsequent atmospheric processing. Here the relative contribution from fossil fuel and biomass combustion will be quantified by molecular combustion markers and powerful isotopic fingerprinting, including microscale-14C dating of BC and OC aerosols. Aerosol samples will be probed from recently established Sino-Swedish observational program in the four populated and industrialization hotspots in China (North China Plain Beijing; Yangtze River Delta Shanghai; Pearl River Delta Guangzhou; Szechuan Basin Chengdu) and from the SE Yellow Sea recipient site on a Jeju Island (Korea Climate Observatory Gosan), providing an ideal context for these investigations. The molecular/isotopic fingerprints of such synoptic aerosol samples provide integrated source signature and possibility to assess atmospheric processing during over-ocean long-range transport. This field quantification of BC and OC sources and processing in E Asia will contribute to (a) top-down observation-based test and improvement of bottom-up technology-based emission inventories (uncertain for small-scale and open combustion); (b) improved aerosol parameterization in climate and air quality models, and (c) scientific underpinning for policy makers to make efficient mitigation actions toward decreasing anthropogenic aerosol emissions.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STOCKHOLMS UNIVERSITET;SE;;; 195872;660021;DEDMEE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Derivation of Effective Dynamics from Microscopic Evolution Equations;1/06/2015;31/05/2017;;"The derivation of macroscopic (effective) equations from microscopic considerations is a long-standing challenge of the mathematical analysis of many-body problems. In this research proposal, we focus on the derivation of (linear or non-linear) kinetic and Hartree-type equations from microscopic quantum models.
The innovative and creative potential of the project relies on the combination of rigorous methods of Quantum Field Theory (QFT) and Quantum Statistical Mechanics (QSM).
Particular attention will indeed be paid to the macroscopic properties of interacting quantum systems governed by a microscopic dynamics. The latter is a notoriously difficult mathematical problem for which only few rigorous results exist. The proposed research will yield significant outcomes in this field, while developing important knowledge transfers, locally between the researchers Sbastien Breteaux, Jean-Bernard Bru and Miguel Escobedo, and globally between BCAM and TU Braunschweig, the University of Paris Nord, ETH Zrich and the University of So Paulo";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BCAM - BASQUE CENTER FOR APPLIED MATHEMATICS ASOCIACION;ES;;; 195854;659860;MINDS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multivariate analysis for the Imaging of Neuronal activity using Deep architectureS;11/01/2016;10/01/2018;;Functional magnetic resonance imaging (fMRI) is the dominating approach to research in the mapping of neural activity in the human brain. State of the art data analysis techniques employ a statistical parametric mapping (SPM) strategy to convert raw signal into interpretable images by processing data in a pipeline of task-specific modules. This approach, despite its simplicity and reliability, presents a set of inconveniences, including low interconnectivity among modules, resulting in suboptimal solutions. In this project we aim at making a major contribution to the field by replacing the step-by-step data processing pipeline by a deep neural network. We hypothesise that this will achieve better solutions by propagating the effects of module-based decisions through the network, jointly optimizing the whole processing pipeline. Moreover, fMRI low temporal resolution will be alleviated by means of a post-processing treatment, where advanced interpolation techniques will be used. We will release a freely accessible software tool that integrates with SPM, supplying an easy-to-use framework including advanced techniques for an automatic multivariate non-linear data analysis. The generated deep network solution will be applied in a multidisciplinary study in neurofeedback, where subjects will learn relaxation strategies guided by fMRI technology. At the end of the project, we expect our tool to become a useful standard practise in the field.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DANMARKS TEKNISKE UNIVERSITET;DK;;; 195829;659668;EVOLPREG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Origination of novel gene regulatory networks in the evolution of mammalian pregnancy;12/04/2016;11/04/2018;;One of the deepest unanswered biological questions is how new phenotypes arise in evolution. To address this question, I propose to investigate a major mammalian innovation: pregnancy. Phenotypic novelties of pregnancy include efficient placental delivery of nutrients and internal fetal development. When being established, these novelties were associated with major gene regulatory changes in the endometrium of the uterus. My preliminary studies in human endometrial cells suggest that aryl hydrocarbon receptor (AHR) regulates genes that are essential for placental development and maternal immunotolerance of the fetus. It is also known that AHR evolved endometrium-specific expression early in the mammalian ancestor and acquired the ability to repress estrogen signalling necessary for implantation only in placental mammals. Here, I propose to study the origination of novel endometrial gene regulatory networks of AHR. I will establish the full endometrial target gene sets of AHR in major placental lineages and a non-placental out-group (opossum). Potential AHR targets will be validated in endometrial cells using knockdowns and reporter assays. The results of this study will provide a paradigm for understanding how transcription factors integrate into a new cell-signalling network. The findings will also expand our knowledge of the mechanisms of AHR-mediated toxicity of dioxins in mammalian reproduction and may reveal new therapeutic targets for the treatment of female reproductive disorders such as preeclampsia and endometriosis.;191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;TURUN YLIOPISTO;FI;;; 195832;659677;BactoDrug;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Bacteroides dual-pumping membrane-integral pyrophosphatase: a novel drug target;1/06/2015;31/05/2017;;"Membrane-integral pyrophosphatases (M-PPases) couple cleavage of pyrophosphatase to pumping of ions across a membrane to generate membrane potential and play an important role in resistance to stressors. The solved structures of an H\-pumping M-PPase from Vigna radiata and an Na\-pumping M-PPase from Thermotoga maritima show M-PPases form a channel through the membrane, and this channel is plugged by an ion gate formed by three charged residues. Despite these structures, there are still many outstanding questions regarding M-PPases, especially in relation to H\ and Na\ dual-pumping M-PPases.

Bacteroides species are a major cause of anaerobic infections, and though they are part of a healthy human gut flora, when these bacteria escape the gut, they can cause bacteremia and abscess formation. Bacteroides species are associated with high antibiotic resistance rates and have a 19% or greater mortality rate. However, they do possess a possible drug target: an H\/Na\-pumping M-PPase.

A major goal of this project is to solve the structure of the Bacteroides vulgatus H\/Na\-pumping M-PPase to guide mutational studies to determine how M-PPases select for ions and to explore how the ion gate is opened and closed during ion pumping. Since the ion gate is closed in all M-PPase structures to date, I will also use single molecule fluorescence resonance energy transfer and total internal reflection fluorescence microscopy to determine the kinetics and conformational changes during ion gate movement. Finally, I will use molecular mechanics modeling to simulate ion gate function and design small-molecule drug candidates. Molecules that trap the ion gate in the open conformation will convert M-PPase into a pore in the membrane of Bacteroides species, leading to collapse of the membrane potential.

This project will further my career goal of pursuing research in bacterial pathogenesis from various perspectives, utilizing X-ray crystallography and single molecule technologies.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LEEDS;UK;;; 195640;658694;EUMIGRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New European Mobilities at times of Crisis: Emigration Aspirations and Practices of Young Greek Adults;1/07/2015;30/06/2017;;With Southern Europe suffering deeply from the financial crisis, a renewed public discussion on emigration from this region has emerged. The European South, which had only recently become a destination for immigration, seems to be experiencing a new major emigration wave. This is especially true for Greece, the country which has been hit hardest by the economic crisis and concomitant austerity measures. Despite public attention on the matter, however, little is known about who is emigrating, what alternative mobility strategies are considered and pursued, or the reasons underling migration decisions. EUMIGRE will provide an answer to these questions by introducing an innovative mixed methods approach. This approach allows identifying and studying a sizeable and diverse group of young adults whose spatial and social trajectories are retrospectively traced to explore the influence of the current crisis on their strategies. In so doing, it will also contribute to migration theory at a period when space-time flexibilizations, processes of neoliberalization, and the economic crisis are changing established modalities of and motivations for migration in ways that render the emigrationimmigration country distinction obsolete.;164653,2;164653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF MACEDONIA;EL;;; 195747;659223;MEBA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular epidemiology of Bacillus anthracis: novel data and techniques for local surveillance in Tanzania;2/11/2015;1/11/2017;;Anthrax is described by the World Health Organization as a disease that perpetuates poverty by attacking not only peoples health but also their livelihoods. In the Serengeti region of Tanzania, where income is largely based on agriculture and tourism, regular outbreaks of anthrax in both livestock and wildlife have devastating impacts. Understanding and controlling the spread of Bacillus anthracis, the bacterial agent causing anthrax, in this environment is currently impeded by a lack of data on the genetic diversity and appropriate typing schemes to resolve fine-scale genetic differences. I propose to quantify the genomic diversity of B. anthracis in the Serengeti region of Tanzania and to use these data to develop molecular diagnostic and genotyping tools that can be implemented locally to facilitate surveillance. First, whole-genome sequencing will be performed on isolates obtained from wildlife and livestock carcasses and environmental samples collected through passive surveillance. Bioinformatic analyses will enable single nucleotide polymorphisms (SNPs) to be identified that can distinguish among locally-circulating B. anthracis strains and test for epidemiological links between outbreaks. Based on these SNPs, a multi-locus typing scheme will be developed. To further support local laboratory capacity, I will apply recently developed techniques to obtain high quality genomic DNA from environmental samples without the need for bacterial culture, thus greatly reducing the biosafety risks associated with anthrax surveillance in low-biocontainment facilities. This project will generate important baseline information on the diversity and transmission of B. anthracis in the Serengeti. Additionally, facilitating the local implementation of molecular surveillance will eventually allow us to determine the circulation patterns of B. anthracis at the wildlife-livestock interface in Tanzania, providing essential information for anthrax management in sub-Saharan Africa.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 195870;659999;MicroFert;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Novel Release-on-demand micronutrient fertilisers for crops;1/08/2015;31/07/2017;;"In many important agricultural crops successful fertilisation with micronutrients can lead to substantial increases in diseases resistance, marketable yield, and improved nutritional quality of food and feed. However, the plant availability of supplied micronutrients is usually too low due to the high reactivity of fertilisers under unfavourable soil conditions.
Recently novel concepts for designing fertilisers have been adopted which try to extend their time of availability in the soil in different ways. This proposal, introduces the release-on-demand concept in which the plants themselves trigger the release of nutrients from nanoparticles at the time in their growth cycle that they need them. Layered Double Hydroxides (LDHs) are currently being developed in the host institution and are interesting candidates for the controlled release of micronutrients. LDHs consist of alternating layers of positively charged metal hydroxides and interlayers of anions so they can include both di and trivalent metal cations and different interlayer anions. The nutrient release is expected to be dependent on rhizosphere acidification via root excretion of protons, low molecular organic acids and CO2.
The overall objective is to evaluate the potential of LDHs as release-on-demand micronutrient fertilisers, mainly focusing on Zn, Mn and Cu, and their interactions with N, P or K under a range of soil conditions and growing conditions. Experiments will cover both improving commonly used techniques and novel methods and designs leading to the formulation of patents, the development of novel fertilisers and crop production of increased yield and quality.
The applicant has a very strong background in the characterisation of micronutrient fertilisers acquired during her PhD and postdoc experience that, together with the experience and facilities of the host and partners, will lead to the successful completion of the project and to the strengthening the career development of the researcher.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195740;659204;SHAPED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;SpeecH and Auditory Processing: Effects of Development;2/11/2015;1/11/2017;;Learning a language involves recognizing the acoustic properties of speech sounds that have a functional role. The abilities of perceiving and processing speech sounds are first constrained by basic hearing abilities. The auditory system extracts and processes the acoustic properties from the input language and thus, fully contributes to the development of phonetic categories. Surprisingly, information concerning the interaction between basic auditory capacities and early development of speech processing is still lacking. The present project seeks to combine two approaches to explore this interaction: developmental psycholinguistics, studying the acquisition of a language, and psychoacoustics, describing the auditory mechanisms linked to the perception of speech sounds. First, this project aims to investigate when and how auditory and speech processes interact. The perception of the speech acoustic information (such as spectro-temporal modulations described by psychoacoustic studies) will be assess in adults and infants from different language environments. Second, this project aims to explore further this interaction by investigating the effect of impaired auditory processes on speech perception development. The perception of speech acoustic information will be assessed in hearing-impaired children having access to the hearing world through hearing aids. This research project highlights an innovative multidisciplinary perspective within the speech perception development field. This project will have significant impacts on 1) general health (i.e., auditory rehabilitation for hearing-impaired children) and 2) language education (i.e., perception of foreign languages during development).;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195763;659291;ShadOmIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Shadowing, Omega Limit Sets and Internal Chain Transitivity in Dynamical Systems;30/08/2015;29/08/2017;;This project aims to bring Dr Jonathan Meddaugh, one of the most promising young dynamicists of his generation, to the University of Birmingham to work with Dr Chris Good on a project that aims to capitalize on recent exciting developments in the theory of dynamical systems. Key to the analysis of dynamical systems are the asymptotic behaviour captured by limit sets and an understanding how computed (approximate) orbits correspond to true orbits, i.e. how pseudo-orbits are shadowed by real orbits. In recent work, Meddaugh has shown that shadowing is closely linked to characterizations of limit sets in terms of internally chain transitivity developed by Good and his collaborators. This project will develop the general theory behind these links and, using innovative applications of non-Hausdorff topologies and symbolic dynamics, make significant contributions to our understanding of shadowing and limit sets in a number of important families of dynamical system, such as shift spaces and polynomial maps on their Julia sets. During the project Meddaugh will develop the professional skills that will place him in an ideal position to secure a leading academic position.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195804;659505;IPEIBD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification of promoters and enhancers specific for inflammatory bowel disease and its subtypes;1/06/2015;31/05/2017;;"Inflammatory bowel disease (IBD) comprises two main types of intestinal disorders: Crohns disease (CD) and ulcerative colitis (UC). The incidence and prevalence of IBD is highest in Europe and North America (incidence up to 24 per 100,000 person-years). IBD is not well-understood on a molecular level, and is challenging to diagnose correctly. As the disease is chronic, patients typically require life-long treatment, often with very expensive biological drugs, which are not always effective. Thus, there is a need to increase our understanding the disease, and develop better diagnostic methods so that the correct medication can be applied.
In this project we will analyze a unique emerging dataset of controlled gut biopsies taken from a large number of both UC, CD and healthy individuals (109 total) subjected to a unique RNA sequencing technology CAGE that can identify novel gene isoforms, transcribed enhancers and non-coding RNAs. As shown in our pilot study, such RNA has great potential as diagnostic biomarkers or even drug targets. The most significant RNA predictors for different IBD subgroups will be used as targets to develop diagnostic kits that will be validated, and ultimately applied, in a clinical setting. The host group of professor Sandelin has set up the CAGE technology that will be used for this analysis and the researcher, Dr Vitezic, did her PhD work on the analysis of data from this technology including human tissue samples while in Japan. The project is involving excellent academic and clinical environments and the applicant will spend time in both. This is a unique clinical genomics proposal focusing novel technology and European strengths, targeting a growing medical problem. Thus, it fits perfectly with the goals for the IF and Horizon 2020.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195786;659420;HELICOMBX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum spin Hall insulator with two dimensional crystals;1/06/2015;31/05/2017;;"Dissipationless electrical transport is a key paradigm to reduce energy consumption in our society. Recent advancements in condensed matter physics have revealed that there exist ballistic transport channels at the surface or the edge of topological insulators. These states are preserved by time-reversal symmetry and robust against back scattering. Exploiting topological insulators is therefore a major step for future nondissipative nanoelectronics.
Nevertheless, such a topological phase of matter has been discovered in very few kinds of materials so far. Most of the existing materials are difficult to fabricate, which limits scientific endeavor to explore their properties and also future application. Recently, several theoretical studies have demonstrated that atomically thin graphene or other two dimensional crystals may become two dimensional topological insulators (quantum spin Hall insulators) by inducing large spin-orbit interaction. These materials are rich of novel physics and attract growing attention in their own right. Moreover, they are easy to prepare by mechanical exfoliation, which facilitates to apply them to real nanoelectronics devices.
HELICOMBX is the first project which aims at establishing a basis for dissipationless electronics and spintronics with graphene and transition metal dichalcogenides and unifying physics in topological phase, spintronics and two dimensional crystals. The project is divided into three parts. First we will induce large spin-orbit interaction in graphene by adatoms deposition and heterostructures construction with transition metal dichalcogenides. Spin-orbit interaction of each system is then measured by magnetotransport measurements. Second we will exploit these functionalized two dimensional crystals for spintronics devices. As the final part, quantized conductance will be measured as a signature of the edge states, and we will integrate it into Josephson junctions to observe the Majorana fermions.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195968;660571;EMINCOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;EMIGRANT POLITICAL INCORPORATION: POLICIES AND PRACTICES;1/09/2015;31/08/2017;;"Internationally mobile citizens pose a challenge to policy-makers concerned with their political rights and participation. There has been a remarkable rise in countries extending voting rights to their non-resident citizens (emigrants) over the last two decades with 115 countries granting such rights by 2007. This project will examine the political participation and incorporation of emigrants along two main research objectives: First, it investigates the policies and politics of emigrant participation by questioning why states grant emigrants external voting rights. This will be done through a mixed methods approach including a) a large-N study where the main predictors include both transnational and domestic political variables; and b) a focused comparison of three cases (Spain, Italy, France) which compare the role of key stakeholders (including political parties and emigrants) in both the initial process of emigrant enfranchisement and subsequent restrictions or extensions to these rights. Second, the research focuses on practices and processes of emigrant political incorporation. This will be analyzed through a comparative study of the emigrant candidates based in North America, which are running for office in parliamentary elections in Italy and France. The project will compare the profile, motivation and strategies of the candidates in their negotiation with the political parties for whom they candidate. The research, to be carried out at Harvard University and the Autonomous University of Barcelona, presents a unique opportunity to build a transatlantic network and strengthen both my analytical and methodological toolkit. This will significantly enhance my career prospects. The project is expected to contribute to European policy debates on how to ensure more effective political participation of mobile citizens in their homeland.";171126;171126;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITAT AUTONOMA DE BARCELONA;ES;;; 195811;659549;GLANCE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;calculatinG heaLth impActs of atmospheric pollutioN in a Changing climatE;1/07/2015;30/06/2017;;"Current annual global estimates of premature deaths from poor air quality are estimated in the range of 2.6-4.4 million, and 2050 projections are expected to double against 2010 levels. In Europe, annual economic burdens are estimated at around 750 bn . Climate change will further exacerbate air pollution burdens; therefore, a better understanding of the economic impacts on human societies has become an area of intense investigation.
European research efforts are being carried out within the MACC project series, which started in 2005. The outcome of this work has been to establish a European capacity for Earth Observation, known as Copernicus. In MACC, key pollutant concentrations are computed at the European scale and globally by employing chemically-driven advanced transport models. The proposed work in GLANCE would develop a novel integrated assessment model for calculating the health impacts and damage costs of air pollution at different physical scales. It would combine MACC (assimilated Earth Observations, an ensemble of chemical transport models and state of the art ECWMF weather forecasting) with downscaling based on in-situ network measurements.
The strengthening of modelled projections through integration with empirical evidence would, therefore, reduce errors and uncertainties in the health impact projections. In addition, GLANCE would yield improved data accuracy at high time resolution. This project is a multidisciplinary approach which would bring together leading experts from natural sciences and socioeconomic fields. The fellow would benefit from learning new and multidisciplinary skills, collaborating in international networks, and publishing novel results in high impact journals. Moreover, GLANCE would benefit the European community by contributing a novel approach to assess air quality at the local and regional levels, thus benefiting to long running EU commitments, while exploring new pathways for exploiting earth observational data.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASOCIACION BC3 BASQUE CENTRE FOR CLIMATE CHANGE - KLIMA ALDAKETA IKERGAI;ES;;; 195817;659614;SWITCHCATALYSIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Switchable catalytic activity of spin crossover materials;1/06/2015;31/05/2017;;"Spin crossover (SCO) is an intensively studied and highly versatile representative of molecular switches. The change of numerous physical properties during the spin transition has provoked a wide inclusion of SCO materials into various electronic, photonic and mechanical experiments. The main question asked in this project is how the drastic electronic and structural reorganizations accompanying spin transition will influence the catalytic activity of SCO complexes and composites. These studies will cover the redox catalytic activity of SCO molecular complexes, nanoparticles and composites, photocatalytic properties of SCO complexes, catalysis by conjugates with enzymes, and other switchable materials with catalytic activity. The expected results will allow the creation of switchable catalysts and will contribute to the fundamental knowledge on the spin-dependent catalytic activity of metallic centres.
This project aims to combine the background of an experienced researcher that works in the domain of spin crossover materials, and the competence of a hosting group that deals with functional nanoparticles including their catalytic and photocatalytic activities. This combination of expertise supported by the facilities of Johannes Gutenberg University will create the optimal conditions for the realization of scientific purposes included in this project and will conduce to the efficient knowledge transfer between the experienced researcher and the host laboratory.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Johannes Gutenberg Universitaet Mainz;DE;;; 195857;659907;CSDP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Construction of Self-Dividing Protocells;1/08/2015;31/07/2017;;Artificial cells are synthetic compartments that are able to mimic one or more properties of natural cells and provide valuable avenues for the study of fundamental cellular functions. However, thus far there are no examples of synthetic systems/materials that can achieve self-replication. Therefore the key aim of this project is to create artificial self-dividing protocells. I will build a platform that combines synthetic chemistry, cell biology and microfluidics to prepare cell-like systems. Monodisperse picoliter multiple all-aqueous droplet systems (e.g., liposomes) generated by microfluidics will be utilized to construct self-dividing protocells. To achieve division, the so-called Z-ring of the bacterial divisome will be incorporated in droplets, together with an energy-generation system. I have extensive experience in microfluidics research and especially in the preparation of multiple emulsions with complex compartments, which I will exploit in this project. At Radboud University (RU), I will obtain new skills and expertise in biochemistry and biology such as in vitro gene expression, chemical reaction networks, and bottom-up synthetic biology. Importantly, the reconstitution of an artificial cell divisome would lead to a deeper understanding of the biophysical principles of cellular behavior and will be the most fundamental step towards construction of artificial cells. I believe this in vitro reconstituted system provides a revolutionary new platform for biomimetic research.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 195918;660258;EGFR-Activ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Epidermal growth factor receptor (EGFR) activation by cytohesins - Structural Insights;4/05/2015;3/05/2017;;"The epidermal growth factor receptor (EGFR) is a key player in many biological responses and its aberrant function is associated with numerous diseases, including a number of cancers. Despite the significant benefits of anti-EGFR agents in some tumours, many challenges remain in the improvement of EGFR-targeted therapies.
This proposal targets cofactors in the EGFR signalling that, so far, were not exploited therapeutically and hence may not only contribute to the global effort in the understanding of this system but may also open new doors to the development of new therapeutic agents. The aim is to use Nuclear Magnetic Resonance (NMR) to obtain structural insights into EGFR activation covering three main aspects: i) modulation of activity by the transmembrane and juxtamembrane domains, ii) the role of the cell membrane and iii) the role of cytohesins in EGFR activation. For this, selected protein constructs will be prepared and their structure and interactions will be characterized. In parallel, new NMR methodology to improve the study of challenging biological samples, specifically EGFR, will be developed. The work plan will provide an innovative and multidisciplinary training covering different areas in Life Sciences and allow the researcher to experience work in an industrial environment through a secondment.
We anticipate to obtain structural information that contributes to the global knowledge on these systems and to the discovery novel therapeutic agents. Moreover, the innovative methodologies that will be used in terms of the acquisition of multidimensional NMR experiments have the potential to change the way current investigation of challenging biological samples is done by NMR spectroscopy.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Heinrich-Heine-Universitaet Duesseldorf;DE;;; 195814;659576;CRESWUP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Creep resistant steels and welds for ultra supercritical power plants;1/08/2015;31/07/2017;;"Research in the project aims at increasing the operating temperatures and pressures of fossil fired USC power plants by using a new generation of martensitic high temperature steel as structural material. Higher operating pressures and temperatures lead to higher power plant efficiencies and significantly lowered CO2 emissions.

Dr. Chitta Ranjan Das from Indira Gandhi Centre for Atomic Research in India will stay at the Technical University of Denmark (DTU) under guidance of Prof. John Hald, Mechanical Engineering Department.

The project includes characterization and modeling of new advanced martensitic 12Cr and 10Cr steels from the viewpoint of phase stability under creep loads, and a study of dissimilar weld joints between ferritic steel and nickel base alloy for mitigating type IV and fusion line cracking in service. The investigations are towards applications in fossil fired USC power plants with operating temperatures of 650 C as well as in A-USC with operating temperatures of 700 C.

The researcher will acquire skills in advanced electron microscopy techniques and microstructure modeling at DTU, as well as in 3D atom probe at the partner institution Chalmers University in Sweden. He will bring expertise on new welding procedures for longer creep life of dissimilar metal joints to Europe.

In addition to widening the competency of the researcher and the usefulness of the new skills to his parent organization, the fellowship will form the basis for future collaboration between India and partner countries in Europe towards developing high performance materials for USC and A-USC.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DANMARKS TEKNISKE UNIVERSITET;DK;;; 195791;659442;URBANRAD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Radiative transfer effects on air pollution dispersion in urban areas: from the street scale to the neighbourhood scale;1/06/2015;31/05/2017;;"This project aims at understanding the effects of radiative transfer on air pollution dispersion in urban areas at both the street scale and the neighbourhood scale. Numerical models will be developed, for that purpose, that will help design and manage our cities, buildings and traffic systems in order to produce sustainable, safer, healthier, and more comfortable urban environments.

Radiation modelling will be coupled with 3D fluid dynamics, urban geometry, particle and pollutant transport, traffic and environmental conditions to produce the first model able to take into account radiation transport effects at both street and neighbourhood scales. Benchmark numerical simulations at the street scale will provide detailed information on radiative transfer effects subject to various environmental conditions: presence of clouds, humidity, turbulence level, etc. These results will help to derive simple physically relevant models for the simulations at the, much more computationally expensive, neighbourhood scale. The intensive use of fully adaptive methods for both radiation and fluid dynamics will also contribute to make feasible the simulations at this scale.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195839;659739;REALISM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Reducing Early Atrophy with Leucine during Immobilization of Skeletal Muscle;1/05/2015;30/04/2017;;Recovery from injury, illness, and/or disease is associated with skeletal muscle disuse. Muscle disuse leads to a loss of muscle mass, strength, and functional independence, and represents a catabolic crisis for the elderly who are already at a greater risk for low muscle mass and strength due to age-related sarcopenia. Muscle mass is determined by the balance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). When MPB exceeds MPS, the result is a negative net protein balance and muscle loss. Decreased MPS rates occur following the onset of immobilization-induced disuse, but there is no information on the response of MPB. mRNA and protein expression data indicate that the early stages of disuse (0-5 days) result in activation of the ubiquitin proteasome system, and presumably MPB suggesting that the initial stages of disuse represent a critical period to intervene with appropriate countermeasures to attenuate the loss of muscle mass and strength. Leucine is a key amino acid in the regulation of muscle protein metabolism that has been shown to inhibit MPB. The current proposal REALISM will 1) identify whether MPB is elevated during the early stages (72 hours) of immobilization-induced disuse, 2) determine whether leucine can reduce MPB and the loss of muscle mass during the early stages of immobilization, and 3) determine whether leucine can preserve muscle mass and strength in the elderly during more prolonged periods of immobilization. REALISM will identify the mechanisms underlying disuse atrophy in response to immobilization and examine potential therapeutic strategies to offset the loss of muscle mass and strength. The M3 laboratory of Dr. van Loon at Maastricht University (UM) offers the most ideal environment for me to conduct REALISM, and take a major step towards the achievement of my career goal of setting up my own research program and establishing myself as an independent scientist.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT MAASTRICHT;NL;;; 195748;659271;RNA Transport and Control;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechanisms of kinesin-dependent RNA transport and translational regulation;1/06/2015;31/05/2017;;Active mRNA transport and localisation are crucial for spatiotemporal control of gene expression. In neurons, dendritic mRNA transport and local translational control are required for synaptic plasticity and memory formation. Misregulation has been linked to severe diseases. RNA-binding proteins (RBPs), kinesin motor proteins, mRNAs and noncoding RNAs (ncRNAs) are involved in dendritic mRNA transport and translational regulation. Still it is not known which essential set of factors is required to enable kinesin-dependent mRNA transport. Further, many RBPs required for mRNA transport simultaneously act as regulators of translation. How these crucial activities are mechanistically linked is unsolved. To anwswer these questions, this project aims to reveal essential mechanisms by two independent biochemical in vitro reconstitution approaches: (1) I will reconstitute kinesin-dependent transport of a dendritically localised mRNA and noncoding RNA using candidate proteins and RNAs from literature and an unpublished result of the host laboratory. (2) I will analyse the dual function of RBPs in mRNA transport and translational regulation. To this end, a microfluidics-coupled in vitro translation imaging assay (TIA) will be developed to study the effect of RBPs and ncRNAs on translation in real-time. Finally, the in vitro motility assay will be combined with the TIA to investigate the impact of translational regulation on mRNA transport. Using these techniques I will address key questions: (i) Which are the essential components required for kinesin-dependent mRNA transport? (ii) How are mRNA transport and translational regulation mechanistically connected? This project aims to unravel fundamental principles, improving our knowledge of neuronal mRNA transport and gene expression on a mechanistic level. Additionally, the experimental framework developed herein will enable the field to answer further important questions relating to the growing field of localised translation.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO CENTRE DE REGULACIO GENOMICA;ES;;; 195771;659325;FourFeFourS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular Understanding of Generation and Trafficking of Mitochondrial [4Fe-4S] Clusters;15/06/2015;14/06/2017;;Iron-sulfur [Fe-S] clusters play a vital role in numerous cellular functions. They are a sine qua non for cellular energy production and maintenance of genomic stability. Therefore, elucidation of the biogenesis of [2Fe-2S] and [4Fe-4S] proteins is of utmost importance for basic science in its broadest sense, as it is for ongoing efforts to establish their relevance to human disease and their utilization for biotechnological production of fine chemicals in microorganisms. The iron-sulfur cluster (ISC) assembly process is responsible for incorporating the inorganic cluster into [Fe-S]-associated proteins in the mitochondria. Cytosolic and nuclear [Fe-S] protein assembly that dictates cellular iron concentrations and DNA integrity outside of the mitochondria also depends on the function of the ISC machinery. The mitochondrial ISC biogenesis machinery entails at least 17 proteins, yet how the proteins for [4Fe-4S] maturation work in a unified manner to produce the active cluster and transfer it to target proteins remains poorly understood. FourFeFourS intends to discover the underlying mechanisms of [4Fe-4S] biogenesis in the mitochondria, which could shed new light into how dysfunction of the proteins involved may lead to fatal diseases. To this end, studies will combine a biochemical reconstitution assay of the biological process utilizing isolated ISC proteins in conjunction with spectroscopic and spectrometric experiments that elucidate detailed protein function and molecular structure. In carrying out this cutting-edge research under the tutelage of a world-leading expert on iron-sulfur protein biogenesis, I will expand my expertise within the multidisciplinary field of biochemistry in particular my understanding of the roles of metal ions in biology. In the process, I will build a solid foundation for a future research career as a group leader within the European Union.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;PHILIPPS UNIVERSITAET MARBURG;DE;;; 195953;660477;FISHDOPA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dopaminergic neurons and the reward system in fish: a functional neuroanatomical multidisciplinary study;1/03/2016;28/02/2018;;"The current proposal aims at elucidating the role of the dopaminergic (DA) system in regulation and control of reward systems. The study of DA regulation is of great importance since it has been known to regulate reward, as well as other vital neurological functions and several neuropsychological illnesses, but the underlying molecular mechanisms are still not fully understood. With the emerging technologies of in vivo imaging, optogenetics and transgenic techniques, it is today possible to better study the molecular mechanisms underlying reward behaviour. To this end, the zebrafish (Danio rerio) is an excellent model system where these tools are amenable for complex network analyses. It is believed that, as in mammals, DA neurons provide a central role in signal and response to salient stimuli. Therefore in this project we plan to 1. Establish which forebrain DA neuronal populations, brain targets and signalling molecules are active during reward conditions and
2. Establish a causal relationship between these areas and the control of reward-motivated behaviour in fish. We will conduct this research by pinpointing DA neuron populations active during reward situations and their target areas by in vivo calcium imaging analysis and corroborating established focus brain networks by quantifying c-Fos and brain-derived neurotrophic factor (BDNF) expression by means of in situ hybridization (WP1). Thereafter, we will elucidate target molecules that are important during reward processing in established networks, by laser microdissection and a targeted and non-targeted approach, i.e. qPCR and RNA sequencing, respectively (WP2). Finally we will demonstrate causality between focus brain networks and reward oriented behaviour by optical and genetical regulation, i.e. optogenetics, of neural population activity (WP3). Extrapolating information obtained from these results could help predict neurobiological principles that could be the basis for therapeutic interventions.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 195796;659461;Adapting Dickens;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dickens, Adaptation, and the Nineteenth-Century European Theatre;1/01/2016;31/12/2017;;"Adapting Dickens approaches the work of Charles Dickens from a fresh, dynamic, globally engaged perspective. The project considers adaptationsparticularly dramatizationsof Dickens's novels as key sites for international cultural interaction in the nineteenth and early twentieth centuries. Adaptation to the stage transformed Dickens--Britain's emblematic national writer--into an international cultural commodity: the stage, a global network for cultural transactions, interpreted and circulated his work across Europe and the nineteenth-century colonial world.

The research at the heart of the Adapting Dickens project views adaptations as expressions of critical interpretation of literary texts as they comment upon and translate them into new media, other languages, and for consumption by a wide array of audiences. The project draws upon the latest developments in adaptation theory and pedagogy, and it seeks to find fresh venues for researching Europes Dickens; new tools for locating, interpreting, and disseminating work on Dickens and the nineteenth-century theatre; and ways of communicating emerging ideas about Dickens, nineteenth-century Europe, literary adaptation, and cultural currency to audiences beyond the academy. The project will (1) ensure knowledge transfer to Europe and enhance and enrich both European literary and theatre studies;, (2) enhance pedagogical innovation via public performances, classroom outreach activities, web development, and a volume on teaching through adaptation; and (3) contribute to the Fellows professional development through web training, advanced language study, archival research in Europe, and the production of articles and a scholarly monograph.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BRUNEL UNIVERSITY LONDON;UK;;; 195732;659166;NeuroRhomboid;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Discovering the signalling pathways and physiology of active rhomboid proteases in the brain;7/04/2015;6/04/2017;;Proteases control major pathways in the nervous system and aberrant proteolysis underlies many neurobiological disorders and diseases e.g. Alzheimer's and Parkinson's disease. Signal generation and release is tightly regulated by protease activity, as many key signalling factors are synthesised as transmembrane precursors that require cleavage to liberate their active ectodomains. The largest family of intramembrane proteases are the newly discovered rhomboids, which are found in all kingdoms of life. To date, their physiological significance in mammals is largely unknown, as is the substrate-selectivity of most mammalian rhomboids. I have exciting preliminary data that two uncharacterised mammalian rhomboids, RHBDL1 and RHBDL3, are specifically highly expressed in primary neurons in the CNS. Unlike the well-studied RHBDL2 and Drosophila rhomboids 1-3, they do not have activity against EGF-like growth factors, so they are likely to cleave a novel substrate. A major limitation in protease research has been the lack of unbiased and systematic screens for their substrates. Addressing this deficiency, first, I aim to identify RHBDL1/3-dependent substrates in primary neurons, by adapting recently developed biochemical assays, such as SPECS and BioID. My second aim is the mechanistic validation of these substrates. Third, I will be the first to study the physiological role for active rhomboids, using CRISPR-mediated knock-out neurons and mice. By discovering the role and function of RHBDL1/3 in the brain, I will make an important contribution towards the elucidation of the physiological and medical significance of rhomboid proteases in mammals.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195855;659882;Tbet ILC JFN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of innate lymphoid cells in regulating intestinal inflammation;1/05/2015;30/04/2017;;"The maintenance of intestinal homeostasis has local and systemic implications for the host health and depends on a balance regulated by interactions between the immune system and the gut microbiota. Recently, it has become clear that a newly identified group of cells, innate lymphoid cells (ILCs), have a crucial role in intestinal homeostasis and host defence. ILCs respond rapidly to changes in the gut microenvironment and produce several cytokines that regulate intestinal inflammation. Although the pathways responsible for ILCs development and differentiation are only starting to be elucidated, the transcription factor T-bet has emerged as a key regulator of these processes.
This proposal aims to clarify the molecular mechanisms involved in the T-bet-dependent development and function of ILCs and how these processes can be modulated by the intestinal microbiota. First, we propose to use a novel lineage-tracing mouse model that uses dual fluorescence reporters to differentiate between cells that currently express T-bet from cells that used to express T-bet, in order to distinguish between the mechanisms responsible for ILCs development from the mechanisms involved in ILCs function. In addition, we aim to uncover novel T-bet associated pathways that are active on intestinal ILCs, and understand how these pathways are regulated by the gut microbiome. Moreover, we aim to develop a novel in vitro co-culture system of ILCs in intestinal organoids, which will facilitate our studies and benefit future studies investigating the development and functions of intestinal lymphocytes. The detailed study of ILCs development, differentiation and function and the identification of novel T-bet and microbiota associated pathways will open new possibilities in the modulation of ILCs functions and inform on how to divert these cells away from their pathogenic phenotypes that are responsible for gut inflammation and could have a significant impact on the field of intestinal immunity.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195788;659434;MUSICAL-MOODS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;A mood-indexed database of scores, lyrics, musical excerpts, vector-based 3D animations, and dance video recordings;1/12/2015;30/11/2018;;The project aims at the development of an online database of scores, lyrics and musical excerpts, vector-based 3D animations, and dance video recordings, indexed by mood. Such a taxonomy of relations between the musical, linguistic and motion domains will be aimed at interactive music systems and music making. For realising the database, digital scores inclusive of lyrics will be gathered from collections of music in the public domain. Music mood classification using audio and metadata will aim at capturing sophisticated features but using no explicit domain-specific knowledge about a mental state. Datasets will be realised through a cross-modal approach. Validation of the model will be carried out by combining results from an online game-with-a-purpose, for Internet users, and from intermedia case studies for selected dancers. In further case studies, music works will be realised, also by invited artists, for the evaluation of the database in interactive music making. An online call for artists to use the database in music making or sound generation will be aimed at extending the evaluation further. The final database will be made available online for further exploitation. The present research will generate new knowledge for use in next-generation systems of interactive music and music emotion recognition, also contributing to extend the investigation in the broader areas of music making, computational creativity and information retrieval.;244269;244269;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA;IT;;; 195725;659128;NEXTGENPDF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Parton Distribution Function determinations for the future of particle physics phenomenology;1/09/2015;31/08/2017;;"The first run of data taking at the Large Hadron Collider (LHC) at CERN culminated with the discovery of the Higgs boson announced in July 2012 and represented the beginning of a new era in high-energy particle physics. During the LHC Run II, which will start at the beginning of 2015 with the collider running at higher center of mass energy, the experimental collaborations will collect a large number of high quality data that will allow us to test our understanding of elementary particle physics to unprecedented levels and have the potential of revolutionizing our knowledge of fundamental physics. In order to fully exploit the potential of the experiments for precision studies of the properties of the Higgs boson and for searches of physics beyond the Standard Model it is of paramount importance to have access to accurate theoretical predictions for both background and signal processes. Parton Distribution Functions, which encode the information on how quarks and gluons are bound inside hadrons, are one of the fundamental ingredients of theoretical predictions for observables at hadron colliders. Indeed they are often the dominant source of uncertainties on predictions for precision observables at the LHC.
The goal of the NEXTGENPDF project is to make use of all the relevant experimental information from the LHC experiments, the most accurate theoretical predictions, innovative techniques for estimation of theoretical uncertainties and advanced statistical inference methodologies to deliver new sets of Parton Distribution Functions that match the precision requirements of the experiments at the LHC Run II and at future colliders, maximizing their potential for discoveries of new physics.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI TORINO;IT;;; 195903;660157;OPTIMAPIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mapping the neuronal representation in dorsal inferior colliculus through optical imaging, stimulus optimization and optogenetics;1/03/2015;28/02/2017;;Despite being the most accessible subcortical auditory structure, little is known about the dorsal cortex (ICd) of the inferior colliculus. Limited physiological evidence hints at functions regarding detection of frequency-modulation, novel sounds and selective attention. This project tries to address three fundamental questions regarding the ICd, namely: (1) what are optimal stimuli for the neurons in the ICd, (2) why is the neuronal activity in ICd important for the organism and (3) how does the neuronal circuit achieve the necessary computation. Taking advantage of state-of-the-art in vivo optical imaging, I will search for effective stimulus features through a population-wide stimulus optimization approach (WP1). The ability to measure neuronal activity over weeks expands the range of sound stimuli researchers can deliver, providing a basis for a more unbiased stimulus search. Moreover, groups of cells that respond to similar features can be detected, while extra efforts can be diverted towards identifying optimal stimuli for the remaining cells. Secondly, a behavioural paradigm will be developed to probe the effect of selective attention on neuronal activity of the ICd (WP2). At the same time, comparing neuronal and behavioural response will help us understand how neuronal representations translate into percept and actions of the animal. Finally, I will investigate how neuronal activities in the ICd are shaped by projections from other brain regions, through the imaging of synaptic terminals from these inputs and, subsequently, optogenetic manipulations. The results will lead to a major understanding in the sensory processing at the auditory midbrain and the functional significance of its interactions with other brain regions. These research outcomes are not ends in themselves, but will provide the Fellow with a basis for further research as an independent group leader.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM;NL;;; 195802;659491;EpiAnodes;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Heteroepitaxial ?-Fe2O3 photoanodes for solar water splitting;1/10/2015;30/09/2017;;"Within the past 40 years, tremendous progress has been made in both the efficiency and cost reduction of photovoltaic (PV) cells that convert sunlight to electricity. However, one of the main limitations of using solar power as an energy source is that the electricity must be used immediately or stored in a secondary device . Photoelectrochemical (PEC) cells combined in tandem with PV cells offer a solution to this problem by using solar radiation (light) to electrolyze water and generate hydrogen which can then be converted to electricity using fuel cells or be used to synthesize and store hydrocarbon fuels by hydrogenation of CO2 . The hosts (Prof. Avner Rothschild) research group at the Technion Institute of Technology in Israel has recently made a landmark advancement in the quest for efficient solar water splitting. The development of a resonant light trapping technique in ultrathin absorbing films on reflective substrates opens the possibility to overcome the greatest challenge facing efficient water splitting in ?-Fe2O3 photoanodes, namely, the trade-off between optical absorption length and charge carrier collection length. The Experienced Researcher proposes a novel research plan building upon the invention and involving heteroepitaxial deposition of ultrathin Fe2O3 films for solar water splitting. The proposed research is highly innovative and will develop methods for precise control of thin microstructures and their compositions; these will allow for engineering of films that are nearly free of defects which will improve the efficiency of the photoanodes by suppressing bulk recombination and at the same time, cover novel fundamental research directions such as study of doping on ?-Fe2O3 properties without entanglement from microstructural effects, heteroepitaxial multilayer structures with selective charge transport layers, and directional charge transport in ?-Fe2O3.";170509,2;170509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY;IL;;; 195625;658570;NextGen Airliners;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Designing Next-Generation Aircraft via High-Fidelity Computational Models and Optimization;1/06/2015;30/11/2016;;Air transportation is a crucial contributor to the world economy, and thus its continued growth is essential. However, environmental impact and the increase in fuel prices make sustainable aviation a challenge. To address this challenge, we propose to develop state-of-the-art computational tools for the design optimization of next-generation airliners with unprecedented fuel efficiency. We will achieve this by leveraging the expertise of the researcher on high-fidelity computational design of aircraft, together with Airbus vast experience in practical aircraft design, and the network of academics at ISAE. The proposed research is expected to make a lasting impact at Airbus by implementing new computational tools, and by developing design concepts for the next-generation of aircraft.;138807;138807;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT SUPERIEUR DE L'AERONAUTIQUE ET DE L'ESPACE;FR;;; 195824;659648;BetMon;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Delivering better fitness estimators for wildlife ecology and management and effective monitoring;14/05/2015;13/05/2017;;"Fitness is a key concept in basic and applied ecology, and its traits are used to assess habitat quality and derive scientific knowledge used to design and implement management and conservation measures. Assessing fitness requires considering several traits and trade-offs, and long-term data sets with individual identification that are rarely available. As a result fitness proxies such as offspring production are often used as substitute but these do not consider variation in offspring survival and lifespan, which accounts for most variation in fitness is in long-lived species, like many endangered vertebrates. Many studies, and decisions supported by them, involve unknown biases as consequence of the knowledge gap in the relationship between fitness and: the reliability of each proxy; trade-offs among different proxies; and among proxy/monitoring-effort combinations.
This fellowship has secured access to several high-quality, long-term wildlife monitoring data sets to gain insights in: the trade-offs and factors affecting individual fitness; the reliability of commonly used fitness proxies; and the assessment of bias and accuracy of short- medium-term monitoring programs focusing on different proxies.
While working in leading European research groups and gaining excellent training ecological concepts and theory and up-to-date analytical frameworks and methods, the fellow will: (1) provide high quality ecological knowledge on factors determinant of individual fitness and their trade-offs, and on factors explaining offspring recruitment; (2) assess of the reliability of commonly used fitness proxies; and (3) develop best practice and improvements for short-term monitoring protocols used in research, and management and conservation science.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;UK;;; 195799;659474;Glial-Puberty;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of Glial cells in the control of puberty;1/09/2016;31/08/2018;;"Puberty, a key developmental period when the reproductive capacity is attained and sexual and somatic maturation completed, is under the control of a complex series of regulatory mechanisms that are sensitive to endogenous factors and environmental cues. However, characterization of the neuro-hormonal basis of puberty remains incomplete. A wealth of evidence has demonstrated the existence of reciprocal communications between glial cells and neurons; glial cells having an essential role in regulation of the functional activity of the nervous system. In this context, it is well establish that glial cells play an important role in neuroendocrine regulation and participate in sexual differentiation of neuronal connectivity of brain regions involved in the control of puberty. In addition, preliminary studies have demonstrated that kisspeptins induce changes in markers of glial cell activity. Based on this preliminary data, the aim of this proposal is to provide better knowledge of the role of glial cells in the control of puberty and their interplay with kisspeptins, as major gatekeepers of puberty onset in mammals. To this end, we will used both Kiss1 KO and Gpr54-?gal models generated by the host laboratory, which will allow the study of direct effects of kisspeptins on glial cells. In addition, we will generate a mouse model with deletion of Gpr54 (kisspeptin receptor) only in glial cells, to define their precise role in the control of puberty. Implementation of this project will expand our knowledge of the mechanisms for the control of puberty and its deviations, whose prevalence has notably increased worldwide.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195776;659359;EVOLMARIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Rapid evolution and geographic ranges: predicting marine species persistence and distribution in a changing ocean;1/09/2015;31/08/2018;;In marine ectotherms, the breadth of physiological tolerance largely determines species geographical distribution and extinction risk. Understanding the mechanisms underlying environmental tolerance windows and their relation to life history and demography is thus required for predicting taxa sensitivity to global changes more accurately. Specifically, it is imperative to acquire a firm understanding of both plastic and adaptive responses as rescue mechanisms to prevent species extinction, comparing the effects and costs of these mechanisms among closely related species with different biogeography. I propose to compare the capacity for trans-generational plasticity and rapid adaptation to ocean warming and acidification, in geographically widespread and restricted species as a test for biodiversity evolution under global change. My aims are to (1) define if rapid adaptation to multiple stressors can occur, searching for correlations between plastic/evolutionary responses and the width of species geographic range, (2) reveal potential costs associated with plastic/adaptive responses, and (3) draw projections on species demography, persistence, and biogeography under different global change scenarios. To do this, I have identified an ideal study system for which this information can be gathered in phylogenetically closely-related species with similar ecology, but different biogeography, i.e. eight polychaete species of the genus Ophryotrocha (Dorvilleidae). This ambitious project, which draws from the fields of comparative physiology, ecology, and evolution, relies on an innovative, integrative approach that combines experimental evolution, quantitative genetics, macrophysiology and evolutionary theory. More important, it represents an unprecedented opportunity to produce reliable generalisations on the fate of future biodiversity patterns in a changing ocean, which is essential in designing pro-active strategies to reduce global change impacts on biodiversity.;250160,4;250160,4;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195842;659759;RoleOfNEinPerception;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of noradrenaline in human perception: from single neuron to whole brain and behavior;1/06/2015;31/05/2017;;How do external events become part of our subjective reality? Correlative evidence suggests that the locus coeruleus-noradrenaline (LC-NE) system might play a key role in this process: LC-NE activity is markedly reduced in sleep and anesthesia and reinstated upon recovery of conscious perception, while during wakefulness it correlates with markers of conscious perception. However causal evidence, as well as sensitive experimental paradigms that carefully manipulate awareness in this context, are absent. This proposal aims at providing this missing causal link by pharmacologically manipulating NE levels bi-directionally in healthy volunteers performing liminal visual and auditory perceptual tasks, while reporting their subjective perceptual state. Neural signals will be recorded using simultaneous EEG-fMRI allowing high spatio-temporal resolution. If indeed NE plays a causal role in enabling conscious perception then reduced NE activity will increase perceptual threshold and give rise to impoverished neural responses, whereas enhanced NE activity will aid perceptual incorporation and effectively drive neuronal activity in high-order cortical regions. In a complementary set of experiments I will use a rare opportunity to record single-neuron and LFP activity from neurosurgical patients performing the same perceptual tasks while using pupillometry as a proxy for momentary NE levels. The exceptional signal-to-noise ratio of these recordings will allow linking precisely localized neuronal activity, momentary NE levels, and perception on a trial-by-trial basis, thereby refining and extending the EEG-fMRI results. The ability to manipulate and measure NE levels in subjects reporting their subjective state in sensitive perceptual paradigms, together with comprehensively examining neuronal activity from the level of individual neurons to the whole brain, promise to yield unique results that will shed new light on the neurobiological underpinnings of conscious perception.;182509,2;182509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;TEL AVIV UNIVERSITY;IL;;; 195733;659168;Graphene Membranes;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ultrapermeable Atomically-Thin Membranes for Molecular Separations;1/10/2015;30/09/2017;;"Membranes offer effective solutions for a wide range of separation processes, such as desalination, water treatment, air filtering, biomolecular detection and gas separation. Despite their effectiveness versus other separation methods, the conventional membrane concept is based on either long and tortuous pores, or solution-diffusion, both limiting the permeation rates and causing fouling. A new paradigm to overcome this limit is to use atomically-thin pores, which do not exert any hindering force during permeation, yielding ballistic mass transport. Recent advances in graphene technology enabled the realization of this new concept, and indeed, our recent work has demonstrated ballistic gas transport through graphene pores covering a sub-mm area (Science 344 (6181) 289, (2014)). In this proposal, we focus on this atomically-thin membrane concept, and aim to: (1) develop methods to obtain cm-scale, fiber-frame-supported graphene membrane with sub-10-nm pores, achieving several orders of magnitude faster permeation compared to the best gas separation membranes; and (2) narrow-down the graphene pore diameter to sub-2-nm, and thus demonstrate ballistic molecular sieving for the first time. This project will be a key step to develop the next generation industrial membranes, replacing polymers and other conventional materials by graphene, thus promising significant economic impact. Meanwhile, scientifically, the nanoporous platforms obtained here can also enable the study of nanoscale mass transport phenomena, quantum nanofluidics, and biomolecular sorting and detection.";157845,6;157845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;Bilkent niversitesi;TR;;; 195938;660391;OPTWET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Finding optimal size and location for wetland restoration sites for best nutrient removal performance using spatial analysis and modelling;1/04/2015;31/03/2018;;Diffuse losses of nitrogen and phosphorus from agricultural areas contribute significantly to eutrophication of waterways, lakes, estuaries and coastal zones and water pollution is a growing and serious problem across much of the world. The role of wetlands in improving surface water quality is well known. The capacity of wetlands to improve water quality is dependent on a large number of parameters that have been widely studied, such as vegetation cover or type, water retention time, climatic variables, and also their size and spatial arrangement in the watershed. However, the question where wetlands should be located in agricultural catchments to achieve the most effective nutrient removal at the catchment level has not been clearly resolved. This project aims to determine the optimal sizing and location for wetlands in agricultural catchments to reduce nutrient (nitrogen and phosphorus) loads in catchments. The study consist of two parts performed on study areas with different landscape and climatic conditions. Firstly, potentially suitable wetland restoration/creation sites are identified by using high quality data and geospatial analysis techniques. Secondly, evaluation of the effectiveness of wetland nitrogen and phosphorus removal from surface waters at various potential locations indicated by the geospatial analyses under different hydrological regimes and land use scenarios will be done by using modelling with CLUES (Catchment Land Use for Environmental Sustainability model) and SWAT (Soil and Water and Assessment Tool). Important role in the study is also on using and integrating different datasets and modelling approaches.;240507;240507;H2020-MSCA-IF-2014;MSCA-IF-GF;TARTU ULIKOOL;EE;;; 195717;659083;DICTAPLOMACY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The international dimensions of authoritarian regime survival: comparing dictaplomatic strategies in post-Soviet Eurasia;15/09/2015;14/09/2017;;"DICTAPLOMACY investigates an understudied dimension of authoritarianism the use autocrats make of diplomacy as a tool of regime-survival. The project analyses and compares the foreign policy strategies and dictaplomatic tactics of four ideal-typical authoritarian regimes in post-Soviet Eurasia, with the aim of modelling the mechanisms whereby diplomacy serves them for external regime-legitimation and authoritarian consolidation.
DICTAPLOMACY is a multidisciplinary project that combines insights and methods from comparative politics, international relations (IR) theories and foreign policy-making analysis. It elaborates an innovative framework for analysing rogue behaviour in contemporary IR. It departs from the idea that the EUs democracy-promotion efforts in Eastern Europe require a better understanding of the foreign policy manoeuvres of post-Soviet authoritarian regimes. In identifying the international components of authoritarian resilience, DICTAPLOMACY also highlights which incentives and coercive means could limit the resilience and contain the diffusion of authoritarian governance. This is a timely endeavour, given the growing assertiveness of Russia in world affairs, and the emerging nuisance capacity of many of its undemocratic neighbours (Belarus, Azerbaijan and Kazakhstan notably) in regional affairs.
Building on the researchers expertise in post-Soviet transition and the geopolitics of Eurasia, as well as on the leading academic experience of the host institution in diplomatic studies, the Individual Fellowship will provide the experienced researcher with a chance to acquire new skills, thus reinforcing her maturity as an IR scholar, as well as the host institutions own visibility in the European Research Area. DICTAPLOMACY is a policy-relevant project with a strong potential to entail cross-disciplinary fertilisation between scientific research and policy-advocacy work as well, thanks to the researchers planned secondment in a think tank.";146462,4;146462,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Collegium Civitas;PL;;; 195781;659383;ABDES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An astrochemical study of the early evolutionary stages of sub-stellar mass objects;1/09/2015;31/08/2017;;Astrochemistry is an inter-disciplinary field that provides an insight into the complex physical and chemical processes at play during the early evolutionary stages in star-formation. Over the last decade, while astrochemical studies have been conducted to understand the early evolutionary stages in high- and low-mass stars, similar work is essentially missing for the least massive stars, called brown dwarfs (BDs). BDs are sub-stellar objects with insufficient mass to burn hydrogen in their cores and shine like stars, but are found as abundantly as Sun-like stars in star-forming regions, making them an equally vital constituent of our Galaxy. ABDES is an innovative inter-disciplinary project, which will deliver radically new advancements in our understanding of the astrochemical processes that occur during the early evolutionary stages in BD-formation. The objectives of ABDES are to characterize the physical and chemical structure of early-stage BDs, and study the fundamental role played by the accretion and outflow processes in shaping their evolution. With the advent of high-class telescopes and instruments with unparalleled sensitivities, it is now feasible to probe deep into the early evolutionary stages of BDs. To achieve these objectives, I have built the largest sample to date of early-stage BDs, using a new set of deep, high-sensitivity, multi-wavelength observations. ABDES will combine these observations with chemical/physical modelling techniques, and provide the first measurements on the astrochemical properties of early-stage BDs. Being an inter-disciplinary research division, the Centre for Astrochemical Studies at MPE, under the supervision of Prof. Caselli, is a great fit to this project, and provides excellent expertise and infrastructure for its successful implementation. ABDES is a pioneering study that will highlight the origins of the faintest stars in our Galaxy, and complete our understanding of star-formation toward the lowest mass end.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195840;659744;ResClust;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Resonant clustering;1/03/2016;28/02/2017;;The extent to which nuclei can comprise lighter nuclear clusters in low-mass systems directly influences astrophysical production and decay rates. However, the scope of clustering away from stability has yet to be fully investigated. This proposal will address this by implementing novel measurement apparatus for exotic clustering in key short-lived isotopes using resonant elastic scattering and at the same time demonstrate an improved spectroscopic tool that can be applied to a wide range of nuclear structure studies. This is possible because of key charged-particle detector expertise of the ER and the Supervisor complementing both the ER's experience in radioactive ion beams and the MC40 cyclotron facility at Birmingham. Birmingham's world-class leadership in clustering and charged-particle spectroscopy make this location an ideal host. The result is a focused proposal that will lead to a flexible tool for extracting precise structure data from radioactive beam experiments, answering questions at the frontiers of nuclear stability, models and nuclear astrophysics. A significant reduction in beam-time required for such investigations will be achieved making the apparatus practical for use at international user facilities while opening more systems to this technique and reducing background.;91727,4;91727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195710;659064;DISHY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Synergistic effects of DISpersant, oil and HYpoxia in a teleost fish: Investigating the impact of oil contamination in hypoxic areas and the use of dispersant as a response technique;30/04/2015;29/04/2017;;"Coastal marine ecosystems are of high socio-economic and ecological importance. However, these ecosystems are under anthropogenic pressures. Among these anthropogenic pressures, two major growing threats are represented by hypoxia (due to eutrophication) and oil pollution. These 2 major threats are particularly presents and coexist in European marine coastal ecosystems. However, scarce studies have investigated the biological impacts of their interaction. Consequently, this project intends to evaluate the potential biological effects caused by oil pollution in hypoxic situations. Additionally, this project will consider dispersant use as a response technique for oil released in these hypoxic areas.
Practically, the research actions will estimate the synergistic biological effects of dispersant, oil and hypoxia on a teleost fish species of ecological and economic importance for Europe: the sea bass Dicentrarchus labrax. The approach will firstly evaluate the hydrocarbons contamination induced by the interaction of stressors (Work Package 1). Then, biological effects will be evaluated, at the sub-individual level, by assessing sensitive indicators related to oxidative stress (Work Package 2). Finally, indicators of ecological significance, related to fish behavior, locomotion and metabolism, will be assessed at the organismal level (Work Package 3). The complementarity between the fellow and the supervisors profiles and the environment provided by the host and partner organizations insure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results. These outputs will permit to inform decision makers on the ecological and environmental issues of oil spill in hypoxic areas and to advise oil spill responders on the appropriateness of dispersant use in these areas.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195756;659239;NP4theLHC14;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New Physics for the Large Hadron Collider: new minimal models of composite Higgs;1/10/2015;30/09/2017;;The discovery of the Higgs boson at CERN marks the beginning of a new era in particle physics. After an impressive forty-year search that has ended making Europe the undisputed leader in particle physics, the finding of the long-sought particle offers us the unique possibility of start testing the origin of the electroweak symmetry breaking. In particular, this means that we could be closer than ever to understand some extremely important unsolved puzzles in particle physics, like the large hierarchy between the electroweak and the Planck scales or the origin of fermion masses. Models of composite Higgs are certainly among the best motivated and attractive scenarios trying to address these issues. They also occupy a prominent place in the forefront of theoretical physics, being the object of study of a large community of particle physicists. In this proposal I present an innovative and compelling scenario within this framework where composite leptons, motivated by minimal implementations of leptons featuring a seesaw mechanism of type-III, can partially or fully replace the usual role of the top quark as a trigger of electroweak symmetry breaking without including any anomalously light partner. The presence of custodial symmetry, customary in realistic incarnations of composite Higgs models, ensures that the required sizable degree of compositeness of the right-handed charged leptons is in complete agreement with electroweak precision measurements. These new scenarios offer a beautiful bridge between flavor, neutrino physics and Higgs physics. Throughout this proposal I develop the main objectives and goals of the research proposed, namely, the precise study of lepton flavor constraints in realistic holographic realizations of these models, the study of their implications on Higgs physics, the possible constraints coming from loop corrections to precision observables, their experimental probes at the LHC as well as the possible relation with Dark Matter.;187419,6;187419,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;;; 195761;659237;PerovskiteHTM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New Hole-Transport Materials to Enhance Perovskite Solar Cells;1/02/2016;31/01/2018;;"The extraordinary recent progress in lead-halide perovskite-based solar cells has largely been based on the properties and processing of the perovskite layer. Inevitably some cell performance limitations are now linked with other component materials, where progress is required to enable the full potential of the technology to be realised:
1. Poor charge mobility and/or high synthesis cost of current organic hole-transport materials (HTMs) incorporated into cells, limiting current collection and cost.
2. Poor moisture stability of the perovskite, limiting device lifetime.
3. Toxicity of Pb, that could preclude some application areas for the devices, or poorer light harvesting if Pb is replaced by Sn.
This proposal tackles all three of these points, through design, synthesis, characterisation, in-house testing and application of new organic hole-transport materials with enhanced properties. This builds upon materials previously developed in the host group, which have already shown excellent promise in perovskite cells.
Crucially, the project will provide a complementary experience for the Fellow that adds to his previous outstanding contributions during his PhD to the area of organic light-emitting diodes (OLEDs). His PhD experience in preparing emissive materials for these electricity-in-light-out OLEDs will now be extended to light-in-electricity-out solar cells. This will give the Fellow a superb overview of both fields such that he can use the synergies in materials development across the whole area as a springboard for his subsequent career.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195923;660295;CACOHET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Causes and consequences of pluripotency gene regulatory network member heterogeneity;1/08/2016;31/07/2018;;How stem cell populations balance the opposing forces of self-renewal and differentiation to maintain a functional population is a question that strikes at the heart of what it means to be a stem cell. Undifferentiated embryonic stem cell (ESC) identity is maintained by transcription factors (TFs) of the pluripotency gene regulatory network (PGRN) centred on the TFs Oct4, Sox2 and Nanog. ESCs with high levels of Nanog self-renew efficiently while ESCs with low Nanog levels are prone to differentiate. Therefore, the observed heterogeneous expression of some PGRN components, in particular Nanog, is likely to be important for simultaneous maintenance of self-renewal and facilitation of differentiation, thereby sustaining functional pluripotency. In this proposal I will unravel mechanisms establishing heterogeneity and characterise the role of Nanog in generating ESC heterogeneity. By determining chromatin binding dependencies between TFs and by using a novel approach to identify functional cis-elements that mediate Nanog action, these studies will illuminate mechanisms regulating ESC phenotype. The hypothesis that pluripotency is generated by heterogeneity in PGRN component expression, that then generates an ESC population in which single cells have distinct intrinsic probabilities for differentiation into specific cell types will be tested. Interfering with PGRN component function locus-specifically using a high efficiency genome engineering strategy, will explore a new method to influence cell-fate. Together, the proposed innovative experiments aim to increase the understanding of the causes and consequences of PGRN component heterogeneity and the regulation of pluripotency that may be of relevance to other stem cell systems. The results will have important implications for ESC biology, in terms of increasing the efficiencies of ESC derivation, differentiation, and the use of ESCs in future cell based regenerative medicine approaches.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195718;659092;WISDOM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Wavelength conversIon in diSpersion engineereD Optical fibres for Mid-IR applications;1/06/2015;31/05/2017;;"Numerous high impact applications, in particular in medical diagnostics, environmental and industrial sensing would benefit from the development of wavelength-agile and cost-effective optical sources and detection schemes operating in the Mid-Infrared (MIR) region above ~2 m wavelength. Existing MIR semiconductor technology and bulk nonlinear optics based solutions present many drawbacks and only partially meet the requirements of MIR applications.
A more powerful and versatile approach to access the MIR spectrum relies on exploiting microstructured optical fibres (MOFs) made of MIR transmitting glasses. By exploiting nonlinear processes inside carefully designed fibres, MIR radiation can in principle be generated or detected using more mature Near-Infrared (NIR) sources or detectors.
This approach offers three significant practical advantages: 1) it is wavelength-agile and reconfigurable; 2) it uses cost-effective and performant NIR source/detector technology; 3) it can generate compact, ruggedized and light-weight all-fibre devices. Despite a great potential, MIR nonlinear fibres are still a rather immature technology, due to the difficulty to fabricate fibres with suitable dispersive profiles in glasses with good infrared transmission. This task requires interdisciplinary skills in fields ranging from glass science, electromagnetics and waveguide modelling, to laser and nonlinear physics and experimental optics.
This fellowship project will provide the opportunity to combine my glass science expertise with the host institution world-renown experience in nonlinear optics and MOF fabrication, with the aim to push MIR nonlinear fibre devices from an academic interest to a real technological reality. The project will target three enabling fibre devices and their use in high-impact applications: a coherent MIR supercontinuum source and two frequency conversion fibre devices for MIR gas sensing and telecoms interband wavelength conversion.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SOUTHAMPTON;UK;;; 195888;660089;COMOVE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploring the impact of social mobilization on cooperation in community-based natural resource management systems: Insights from water conflicts in Spain and Mexico;1/09/2016;31/08/2018;;"Environmental conflicts and related social movements can, under some conditions, help to improve the management of natural resources at local levels; we do not know yet, however, what those conditions are. This project uses social movement and common-pool resource theories to address this gap. For this purpose, the project builds on the work of environmental justice scholars pointing to the uniqueness of socio-environmental movements that involve the participation of local resource-dependent communities.
This is a project of substantial policy relevance. Environmental justice conflicts are an endemic phenomenon in our societies, with more than 1200 instances registered across the world. Many of those conflicts have great potential to improve natural resource management or just the opposite depending on how they are treated. Most importantly, there is an international consensus about the benefits of decentralized management and community stewardship for socio-ecological sustainability; however, such stewardship faces problems of cooperation and institutional failure. The study will shed light on the role of social movements in helping communities with these problems.
Objectives and methods of the project include: 1) a meta-analysis of environmental justice movements in Spain and Mexico to explore variation in movements activities and membership across environmental and governance contexts; 2) a comparative case study of irrigation communities in the Yaqui and Ebro valleys (Mexico and Spain) to explore whether the impact of social mobilization on cooperative management varies depending on the type of leadership and discourses used to mobilize communities, the mobilization activities, and the movements membership; 3) a new model that integrates mobilization and cooperation to better understand community-based natural resource management; and 4) policy recommendations vis a vis the integration of conflict resolution and resource management policies at local levels.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT AUTONOMA DE BARCELONA;ES;;; 195787;659422;CLEF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Conserving the Legacy of Evolution into the Future;1/09/2015;31/08/2017;;Conserving the Legacy of Evolution (CLEF) would provide a comprehensive framework for translating biodiversity datasets into conservation plans. We now have a unique opportunity to improve the outlook for biodiversity by taking advantage of the wealth of newly available data on species ranges, functional characteristics, and phylogenetic data. CLEF proposes to: (1) develop sophisticated, yet easy-to-use biodiversity models that improve our understanding of where diversity occurs and better predict how diversity might change in the future, and (2) integrate the output of these biodiversity models with systematic conservation planning. CLEF would advance a new generation of biodiversity modelling that considers multiple species in one step rather than the standard practice of estimating species diversity by aggregating individual models. Early work has suggested these multi-species biodiversity models show great promise for improving present and future biodiversity estimates, but these models have yet to be comprehensively tested. Here, we will build and test these models for plant species in the French Alps, and compare the outputs to existing process-based models at identical scale and resolution. The second phase of CLEF is to develop a tool that directly uses the outputs of these models in conservation prioritization software. This tool will have the option of including phylogenetic, functional data, and future distributions by building on recent developments in this area. CLEF will demonstrate this approach for 2700 plant species to assign conservation priorities for the entire French Alps Region considering functional diversity, evolutionary diversity, climate and land-use change and protected area status. The methods resulting from CLEF could be used for any species-level biodiversity datasethelping scientists and conservationists better understand, predict, and plan to keep evolutions legacy intact.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195610;658475;ClimatCon;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Climate-resilient pathways for the development of concrete infrastructure: adaptation, mitigation and sustainability;3/08/2015;2/08/2017;;Climate change is one of the key challenges facing the human race in the 21st century. To respond to this challenge new approaches to sustainable development combining mitigation and adaptation, which are referred to as climate-resilient pathways, are needed. The development of such approaches is one of the high priority areas of modern day research that will be addressed in the proposed action in the context of concrete infrastructure. The action aims to develop a comprehensive method based on an integration of the Life-Cycle Assessment (LCA) and Life-Cycle Cost Analysis (LCCA) techniques for the evaluation of the whole life performance of reinforced concrete (RC) structures subjected to carbonation in conditions of climate change. To achieve this both experimental studies and numerical modelling are planned to be carried out. The method will take into account both adaptation and mitigation measures and due to numerous uncertainties involved in such analysis be based on a probabilistic approach. It will be applied to several case studies (i.e., typical RC members located in different climatic conditions) to examine the sustainability performance of different concrete types (traditional and green with blended cements) and repair techniques. The method and other results obtained in the action will provide strong support for decision making regarding the sustainable development of concrete infrastructure.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HERIOT-WATT UNIVERSITY;UK;;; 195827;659666;CICCI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of Intestinal Cancer Cell Invasion;1/04/2015;31/03/2017;;"Approximately ninety percent of all cancer-related deaths are caused by the spread of cancer cells to distant sites rather than the growth of the primary tumour. The process of metastasis formation requires the ability of tumour cells to spread from primary tumours, by invasion of surrounding tissue, and afterwards by spreading to distant organs in order to manifest its devastating consequences for patient survival. The series of distinct steps leading to the formation of metastases has been referred to as the invasion-metastasis-cascade. For many years there has been an absence of genetically engineered mouse models of invasive intestinal cancer to analyse the complex processes occurring during the invasion-metastasis-cascade and the presumably underlying mechanisms such as epithelial-mesenchymal transition (EMT), cancer stem cell populations and mutation rates in the intestine.
Combining adenomatous polyposis coli (Apc)-loss with either p53 mutation or Tgf-? receptor (Tgfbr)-loss results in invasive intestinal carcinoma of mice. The host laboratory generated these two contrasting models of invasive adenocarcinoma, which will be utilized to generate an invasion signature of mRNA and miRNA expression to analyse the underlying processes and important players and targets for future therapies of this initial step of the invasion-metastasis-cascade.
Additionally, by comparing the obtained expression profiles to previously published intestinal stem cell signatures and by using genetic labelling in carcinomas, I will analyse the cell culture and human tissue based theories, which indicate that invasive tumour cells, which underwent an EMT, display increased stem cell properties and numbers. This knowledge will generate important information for future cancer stem cell targeting therapeutic strategies.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BEATSON INSTITUTE FOR CANCER RESEARCH LBG;UK;;; 195809;659541;Imperial Recipes;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Food in the Spanish and British Caribbean in the Nineteenth Century: Encounters, Exchanges, Identities;1/06/2015;31/05/2017;;This research project aims to compare the British and Spanish empires in the nineteenth-century Caribbean. More specifically, it focuses on the discourse on food in the British and Spanish colonies. This project stems from my doctoral research. My aim is both to find a connection between the ways in which food and diet were perceived and discussed in the British and Spanish Caribbean colonies and to evaluate the differences in the discourse on food in the two empires, with the objective of analyzing colonial identities and imperial ideology in the Caribbean through the lens of food. My focus on food and diet sheds light on how encounters, negotiations, appropriations, rejections and interactions of culinary practices are more than just a matter of human nutrition but rather concern fundamental issues as the construction of identities, asymmetries of power, agency of the subaltern and mutual influences. The basic assumption of this project is therefore an analysis of the relationship between food, identity and power.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD PABLO DE OLAVIDE;ES;;; 195774;659338;Subpopulations;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating Fibrotic and Regenerative Fibroblast Populations in Muscular Dystrophy;1/01/2016;31/12/2017;;"Following skeletal muscle injury, resident fibroblasts proliferate and release cytokines that enhance muscle regeneration. Fibroblasts also secrete chemokines to recruit cellular migration, and extracellular proteins that stabilize the site of injury. However, in chronic diseases, such as Duchenne Muscular Dystrophy (DMD), continual muscle damage shifts fibroblasts towards an uncontrolled fibrotic and inflammatory phenotype. Excessive fibrosis and inflammation are prominent pathological features of DMD and inhibit muscle function and repair by replacing the tissue with fibrotic scars, adipose tissue, and necrosis.
The fundamental question my proposal will address is why fibroblasts shift from regenerative-favouring cells in healthy muscle, but lead to fibrotic accumulation in dystrophic muscle. My proposal will use a novel approach to investigate specific fibroblast populations. Whether all fibroblasts are capable of promoting both fibrosis and muscle regeneration, or if there are fibroblast subpopulations that produce factors leading to one or the other outcome, is not currently known. The heterogeneity of fibroblast populations within skeletal muscle remains to be determined. By using lineage tracing and flow cytometry to map cell fate during the progression of muscle degeneration in a mouse model of DMD, my project will identify aberrant changes in fibroblast populations and elucidate how these cells interact with inflammatory cells and satellite cells. Finally, I will extract dystrophic fibroblasts and transplant them into non-dystrophic mouse muscle to determine whether fibroblasts populations can reprogram, or shift, towards a regenerative-favouring cell fate which could lead to a new tailored field of personalized medicines. These provocative studies will be integrated with ongoing research in Dr Morgans laboratory aimed at developing new therapeutics regimens for DMD.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195784;659399;C-Xaq;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cross-Coupling (C-X): Pioneering Mild Aqueous Cross-Coupling Methodologies to Enable Selective Functionalisation and Diversification of Halogenated Natural Products;1/05/2015;30/04/2017;;"Natural Products (NPs) are key to medicine, yet the generation of analogues of these important compounds can often be challenging. I propose to investigate an exciting new approach to NP analogues pioneered by the Goss lab. By developing new, mild, aqueous and selective cross-coupling chemistries I will enable the selective diversification of organic molecules, and in particular NPs, containing carbon-halogen bonds. With my expertise in organometallic chemistry and computational chemistry and in collaboration with the Goss lab, we are poised to bring significant advance to this new field of research.
Over 5000 halogenated NPs have been isolated and identified to date, presenting a series of attractive test-beds for this proposed research. Additionally, with the advent of synthetic biology, it has recently been possible for the Goss group and others to engineer new to nature NPs containing halogen handles. The Goss group demonstrated selective functionalization of these NPs developing and using mild and aqueous Suzuki Miyaura cross-coupling conditions. Building upon this success, I will develop methodology to enable, under mild aqueous conditions, a greater diversity of cross-coupling reactions of aryl halide containing small molecules and then NPs to be employed. I will then embrace the challenge of the selective functionalization of the less reactive vinyl and alkyl halides, first in the presence of small molecules and then in the context of NPs. My reaction design, in this challenging area, will be informed by recent literature precedent, and my own DFT calculations. Success will both enable access to libraries of previously inaccessible NP analogues and provide the first steps toward being able to carry out these chemical reactions in tissues and perhaps even in live organisms in a bioorthogonal manner.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;;; 195702;659008;SocForVul;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The impact of supplementary feeding on the food searching strategies and social behaviour in anendangered top scavenger;1/09/2015;31/08/2017;;The provision of surplus food at supplementary feeding stations is a worldwide practice to facilitate the recovery of endangered species like vultures, which have experienced dramatic population declines during the past century. Despite considerable research on the effects of supplementary feeding on the viability of populations, there is almost a total lack of knowledge on the effects of these practices at the individual level. In the proposed project (Social Foraging in Vultures, SocForVul), I will use the newest advances in bio-logging techniques to investigate the impact of supplementary feeding on food searching behaviour (via GPS/acceleration data-logging) and the social dynamics (via proximity data-logging) of the endangered Canary Egyptian Vulture. This research project aims to combine concepts from the fields of Animal Personality and Social Network Theory, using cutting-edge analytical techniques, to quantify the relative ability of individuals to cope with human-induced environmental changes. The Fellowship will provide me with a unique opportunity to deepen my knowledge on consistent individual differences in behaviour and expertise in the use of modern technology for field research, improve my analytical skills, and develop new expertise in behaviour-based wildlife management. Performing my research at The Doana Biological Station, which is one of the best research locations in Europe for fundamental research and conservation, will guarantee high quality training and excellent research output. The proposed research holds excellent prospects for interdisciplinary collaborations and career opportunities. Finally, from a conservation point of view, information on the impact of supplementary feeding on the social life of vultures will undoubtedly improve current guidelines for this conservation strategy and help sustaining healthy populations of scavengers as well as maintaining important ecological and evolutionary processes.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195741;659211;[e-POM-Bioanal];SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electrobioanalytical Applications of Polyoxometalates;1/06/2015;31/05/2017;;The proposed work will exploit the expertise and know-how of the host institute and the fellow to develop a strategy for the detection and screening of genetic mutations in a highly parallelised fashion.The project has an overall objective to develop an electrochemical single nucleotide polymorphism (SNP) detection strategy by using polyoxometalate (POM) labeled DNA (including PCR primers, dNTPs and ddNTPs) for use in solid-phase melting curve analysis and sold-phase array based primer extension and solid phase ligase mediated detection. In order to achieve this, robust surface for anchoring of DNA probes capable of withstanding elevated temperature for enzymatic reactions either in solid phase melting curve analysis or single dideoxynucleotide incorporation will be developed. The proposed strategies will allow for highly cost-effective, rapid and user-friendly platforms for the screening of genetic mutations and single nucleotide polymorphisms.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;FR;;; 195825;659653;MaNET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Majorana Networks;1/04/2015;31/03/2017;;"The aim of the proposed research project is to establish a new environment for the generation, study and manipulation of Majorana fermions, namely two dimensional electron gases embedded in III-V semiconductors with strong spin-orbit interaction. With respect to the nowadays approach, based on nanowires, two-dimensional materials will allow completely new sample design, paving the way for precise control and complex manipulation of Majorana modes. The ultimate goal will be the realization of multi-terminal networks, where the braiding statistics of Majorana fermions will be investigated. The success of the proposed project will constitute a key advancement for the use of Majorana fermions as tools for quantum computing applications. We will make use of recently developed tools and materials to solve the nowadays technical difficulties in taking experiments on Majorana fermions to a new level.
For our research, we will adopt InAs\InGaAs quantum wells, characterized by strong spin-orbit interaction and large Land g-factor, coupled to superconducting electrodes. As shown by preliminary results, the quality of our InAs samples is unique in terms of mobility and gate stability. The researchers expertise in quantum transport is a good match to the wide experience of the host institution in terms of quantum computation and semiconductor/superconductor hybrid devices. The availability of the state of the art cryogenic equipment, including vector magnets, will allow to experimentally explore completely new regimes in condensed matter physics.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195746;659222;SPAFIL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structured photonics for advanced fibre lasers;6/07/2015;5/07/2017;;"The key goals of the project are: (1) the training of a talented, independent researcher, Dr Amos Martinez, to become a successful leading scientist in the fast growing field of science, technology and industrial applications of fibre lasers, (2) exploring new ways to exploit two-dimensional materials, such as graphene, in photonics through femtosecond laser nanostructuring and developing new classes of light sources for applications in optical communications, medical imaging, industrial manufacturing and metrology. This multidisciplinary project has great implications on laser science, nanotechnology, material science and graphene technologies such as graphene plasmonics, metamaterials, phononics and electronics, and will involve both fundamental and applied research.
The interdisciplinary training scheme is designed to enhance Amoss expertise in photonics, strengthening his skills and helping him establish a research career in Europe. It covers component design and implementation, theoretical analysis, mathematical modelling and nanomaterial characterization. To assist Amos in reaching professional maturity and increase his exposure to academic and industrial collaborations, he will receive training on intellectual property management, funding and proposal writing, commercialization, business and finance management, and supervision and teaching. Secondments in academic and industrial co-hosts, with Prof. James R. Taylor (Imperial College, UK), Prof. Zhipei Sun (Aalto University, Finland), Xtera Communications (UK), Chromacity Lasers (UK) and Optoscribe (UK), are arranged to pursue scientific objectives, maximize Amoss learning experience, expanding his network in Europe and maximising impact of research and training on EU industry.
Exploiting his editorial experience at Nature, Amos will give seminars on effective scientific writing and engage with the public through outreach activities of the Physics Factory and the International Year of Light 2015.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195772;659328;STAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An Extended Local Scattering Theory for Acoustic-radiation and Receptivity of Trailing-edge Flows;31/01/2016;30/01/2018;;"Trailing-edge flows arise in many technological applications, such as aircraft wings in aeronautics and mixing devices in chemical engineering. Two important and fundamental processes take place near the trailing edge, namely the acoustic radiation and receptivity, which refer to generation of sound by fluctuations within the flows and excitations of instability waves by ambient disturbances, respectively. This project will investigate (a) generation of instability waves in the wake as free-stream acoustic and vortical disturbances impinge on the trailing edge; (b) radiation of sound when Tollmien-Schlichting (T-S) waves in the upstream boundary layer propagate through and interact with the trailing-edge flow. Both processes will be analysed mathematically by developing a Local Scattering Theory, which we recently proposed as an appropriate framework for describing the coupling of distinct characteristic motions in a region of strong inhomogenuity. Furthermore, with radiation and receptivity being described properly, we will move on to investigate the so-called acoustic feedback loops, in which instability waves and acoustic waves are generated from each other, leading to self-sustained oscillations. First-principle theories will be developed to predict the intensities as well as the tones (frequencies) of the oscillations. As receptivity, acoustic radiation and acoustic feedback loops are fundamental processes closely related to drag on the wing, jet and airframe noise and mixing of reactants, the present project is of high practical relevance. From the methodology point of view, this project will combine sophisticated asymptotic methods with highly accurate numerical computations, enabling us to tackle a greater range of complex problems, for which numerical or analytical method alone would be inadequate.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195908;660200;S-OS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exosomes as microenvironmental cue for engaging mesenchymal stem cells in osteosarcoma progression;1/01/2016;31/12/2017;;"Osteosarcoma (OS) is a very aggressive malignant bone tumor that develops primarily during childhood and adolescence. It is characterized by rapid growth, a strong tendency for recurrence and an extremely high metastatic potential. In the last three decades OS survival in the presence of metastasis has stagnated at a dismal 30%, clinical trials proved unsuccessful and no major breakthrough in the treatment of OS has been reported. To stop OS mortality, alternative therapeutical approaches urgently need to be explored.
Studies into the molecular and cellular events underlying OS revealed complex and heterogeneous genetic alterations, which challenge the prospect of finding and exploiting an unique molecular driver underlying OS. Because OS onset occurs at sites of rapid bone growth during the adolescent growth spurt, microenvironmental factors and tumor stroma may have a defining role in OS development and progression. Surprisingly, the intercellular cross-talk between OS cells and components of the tumor stroma, in particular mesenchymal stem cells (MSCs), have been poorly investigated.
Here I intend to demonstrate that tumor secreted vesicles called exosomes function as a key microenvironmental factor in OS progression by controlling tumor-stromal cells interactions. Specifically, we aim to explore whether MSC become pro-tumorigenic and pro-metastatic upon interaction with OS exosomes in bioluminescent mouse xenograft models. To identify the molecular signals (i.e. proteins and regulatory RNAs) in OS exosomes responsible for altering MSC behavior, we will employ state-of-the-art proteomics and deep-sequencing techniques. Finally, by means of functional assays we wish to discover the mechanisms by which OS exosome educate MSCs.
The identification of and interference with this completely unexplored layer of communication will lay the groundwork for novel therapeutical approaches to stop OS high mortality rate.";165598,81;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VUMC;NL;STICHTING VU;NL; 195703;659012;NANOLASER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dynamics of semiconductor nanoscale lasers;1/04/2015;31/03/2017;;"Reducing the energy consumption and increasing the density of interconnects have been identified as one of the major challenges in the development of future computing and communication systems. Optics is the only solution for solving this interconnect bottleneck, and the development of miniaturized, efficient, and fast optical sources is therefore of paramount importance. This project addresses these challenges aiming at the theoretical and experimental investigation of the high-speed dynamics of semiconductor lasers at an unconventional scale with the goal of determining their performance and ultimate physical limits for applications in ultra-fast communications, information processing, and on-chip optical interconnects. We target a novel generation of low-threshold electrically-injected metallic cavity semiconductor nanoscale laser (NANOLASER) sources for energy efficient and ultra-fast operation at the 1.55 m fiber-optic communication window.

In these nanophotonic components photons and carriers are both confined in a sub-wavelength cavity and close to the quantum level, with dimensions ranging from hundreds to tens of nanometers and, presenting fascinating new physical phenomena, unique to electromagnetic cavities. Using advanced nanofabrication, characterisation and modelling methods, we aim at fully understanding the the dynamical properties of nanolasers and building predictive dynamical physical models. We will explore their potential for low current operation, ultra-fast modulation and large scale integration. Additionally, a number of optoelectronic and optical injection mechanisms will be investigated for applications in on-off switching and all-optical communications signal buffering. This will have a strong impact on a broad spectrum of scientific fields, namely materials science, laser science, optoelectronics, optical physics, nanophotonics, nonlinear dynamics, and computer science.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITEIT EINDHOVEN;NL;;; 195687;658926;BilMemBrain;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;When language meets memory: the role of language exposure in semantic- episodic memory interaction in bilinguals;1/10/2015;30/09/2017;;"Understanding the implications of the level a language use in how we remember our past is a challenging and relevant goal in our growing bilingual world. Research evidence on memory and bilingualism converges in the idea that the level of language use changes the ability to access semantic representations. At the same time, individuals capacity to access semantic representations facilitates to process semantic information in a relational manner, which subsequently enhances episodic memory. This research project is aimed at investigating interactions between semantic and episodic memory as a function of the language use by means of behavioural and neuroimaging techniques. Basque/Spanish early bilinguals with high proficiency in both languages will be divided in two groups based on their use of languages in their everyday life: balance bilinguals (BB), if they use at the same level both languages; and unbalance bilinguals (UB), if they use one language over the other. We will employ two memory paradigms that are sensitive to semantic-episodic memory interactions. On one hand, categorical memory paradigm will be used to examine beneficial influences of categorical processing on episodic memory; and on the other hand, Deese-Roediger-McDermott paradigm will provide a measure of false episodic memories that will be modulated by relational semantic processing. In both paradigms, no differences between languages would be expected for BB. In contrast, UB in less used language condition would show decreased level of categorical memory and fewer false memories comparing with more used language condition. Regarding neuroimaging procedures, fMRI will allow us to examine brain pattern activations, connectivity and pattern prediction related to semantic processing and memory and to look for neural differences associated with the level of active use of a language. All this will facilitate the understanding of the intricate relationship between bilingualism and memory.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE;ES;;; 195695;658988;PS-IRAQ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Performing a State: State-building in Iraq (2003-2006).;1/04/2016;31/03/2018;;"PS-IRAQs objectives: 1) study the relationship between knowledge production and political engineering in state and nation-building of occupied Iraq (2003-6); and 2) analyze how scientific knowledge of the state acted as a constituent element of political agency. This project also seeks to 3) develop detailed analysis of 2 sites of state and nation-building in Iraq (2003-6). The cases are the occupations and US efforts in: 1) restoring electrical supply and rebuilding the national electrical grid; and 2) the introduction of new Iraqi representative bodies. This project is interdisciplinary, drawing on comparative politics, the anthropology of state and economy, political geography, and social studies of science and technology. It examines how scholars from history, political science, political economy, anthropology and social theory have understood Iraq prior to and after the invasion, and how they engaged in the making and the transfer of ideas about the state. Data-collection relies on archival, library-based research, and interviews. The project generates conceptual and empirical insights relevant to European external action in Southern and Eastern Mediterranean Countries, especially crisis response and state-building. European excellence and innovation is promoted by developing a reflexive understanding of the relationship between social science knowledge and state-building practice and policy. Lessons from the US experience enhance the mutual understanding of US policy formation and social scientific knowledge formation processes. This will enhance potential for European international cooperation on state-building.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT GENT;BE;;; 195769;659316;CYBERNETS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cybernetic Communication Networks: Fundamental Limits and Engineering Challenges;1/06/2015;31/05/2017;;"This Reintegration Panel proposal, CYBERNETS, focuses on the study of Cybernetic Communication Networks (CCN). CCNs are wireless networks that are context-aware, possess learning capabilities and artificial intelligence to guarantee reliability, efficiency and resilience to changes, failures or attacks via autonomous, self-configuring and self-healing individual and network behavior. Typical examples of CCNs are beyond-5G cellular systems and critical communication systems, e.g., law enforcement, disaster relief, body- area, medical instruments, space, and indoor/outdoor commercial applications. A practical implementation of a CCN requires extending classical communication systems to embrace the dynamics of fully decentralized systems whose components might exhibit either cooperative, non-cooperative or even malicious behaviors to improve individual and/or global performance. In this context, CYBERNETS aims to develop a relevant understanding of the interactions between information theory, game theory and signal processing to tackle two particular problems from both theoretical and practical perspectives: (I) use of feedback and (II) behavior adaptation in fully decentralized CCNs. In the former, the main objectives are: (i) to determine the fundamental limits of data transmission rates in CCNs with feedback; and (ii) to develop and test in real-systems, transmit-receive configurations to provide a proof-of-concept of feedback in CCNs. For the achievement of these practical objectives, CYBERNETS relies on the world-class testbed infrastructure of INRIA at the CITI Lab for fully closing the gap between theoretical analysis and real-system implementation. In the latter, the main objectives are: (i) to identify and explore alternatives for allowing transmitter-receiver pairs to learn equilibrium strategies in CCNs with and without feedback; (ii) to study the impact of network-state knowledge on scenarios derived from the malicious behavior of network components.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;FR;;; 195873;660022;SkillUp;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Skill development and firm upgrading to sustain the competitiveness of the EU manufacturing sector;18/09/2015;17/09/2017;;"In the last decades, European manufacturing has been the object of an intense reorganisation driven crucially by multinational firms offshoring strategies that have led to the emergence of global production networks. European companies have mainly devoted their efforts to presiding over high value-added upstream and downstream activities whilst offshoring low value-added operations to low labour cost economies. The hollowing out of manufacturing activities is impacting on the EU labour market: it affects the demand of jobs in the EU, and the local and regional stock of competences, raising concerns over a mismatch between firms skill needs and persistent skill shortages. The aim of SkillUp is to explore routes that combine firms upgrading strategies with workforce skill development in order to enhance the competitiveness of EU manufacturing industries. SkillUp focuses on: 1) which skills are needed for the jobs of today and tomorrow: in which industries? in which regions? 2) are these skills available and where can they be found? and 3) how should such skills be created and what training/education needs to be put in place for this be achieved? Long term European socio-economic growth rests of maintaining a competitive manufacturing sector necessarily in high value added industries, and SkillUp will identify the appropriate sets of skills needed to meet firms demand and enhance EU manufacturing competitiveness. The study will use a mixed method research: 1) inferential statistics (t-test) on the EU labour participation using EU Labour Force Survey; 2) a multiple case-study approach by collecting primary through firm-based interviews and secondary data from company reports as well as industry and regional aggregate data from Eurostat and the Labour Force Survey; 3) Fuzzy-set Qualitative Comparative Analysis - Boolean algebra and set theory - will be applied to detect interaction effects amongst firms upgrading strategies and workforce skill development.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195766;659306;ORRmetIR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development and in situ Infrared study of Novel Strained Core-shell Electrocatalysts: Towards an Understanding of the Oxygen Reduction Mechanism;1/04/2015;31/03/2017;;"The oxygen reduction reaction (ORR) is critical in fuel cells (FC), batteries and corrosion. Sluggish kinetics of the ORR remains a key barrier to efficient electricity generation in FC operating on renewable fuels such as hydrogen or alcohols. Poor understanding of the ORR mechanism has hindered development of cost-effective and improved FC catalysts.
This project aims to bring about a step change in development and understanding of ORR catalysts by (i) synthesising metal nanoparticles with a strained surface structure, and (ii) developing and implementing new in situ and operando infrared (IR) spectroscopic techniques to understand how strain impacts the ORR mechanism. Novel strained core-shell Pt-based catalysts will be developed, featuring a core of inexpensive metals including Ni, Co or Cu. For the first time, insight into the ORR mechanism for supported electrocatalysts under realistic catalytic turnover will be gained by modifying an approach to combining IR spectroscopy and electrochemistry developed in the Vincent group.
The University of Oxford is uniquely suited for this ambitious project: the applicant will be hosted in a strong research culture in catalysis, have access to state-of-the-art research infrastructure and technical expertise in spectroscopy and materials characterisation and industrial collaborations. The fellow will receive broad-ranging training in the synthesis of catalysts and surface characterisation. The host team will benefit from her skills in in situ vibrational spectroscopy, especially spectral interpretation of ORR intermediates.
This highly interdisciplinary project combines nanomaterial synthesis, spectroscopy and electrocatalysis, and has strong potential for generation of intellectual property and commercialisation of new catalysts for FC, aiding knowledge transfer between academic and industrial sectors. This will increase Europes competitiveness in FC and electrocatalysis, supporting Horizon 2020s Energy Security goals.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195595;658358;SIDEW;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Seabed Imprint of Dense Shelf Water Cascading;1/04/2016;31/03/2018;;"Dense shelf water cascading (DSWC) is an atmosphere-driven seasonal phenomenon that occurs in marine regions off Europe and elsewhere. DSWC starts when surface waters over the continental shelf become denser than surrounding waters and sink, generating a near-bottom turbulent flow that moves downslope along the seabed. This process contributes to the deep ocean ventilation and in the global thermohaline circulation (and hence global climate), and involves the massive transfer of energy and matter from shallow to deep waters. While frequently cited as a possible control of the seafloor morphology, there is a lack of studies isolating the DSWC geomorphic effects from other processes known to shape continental margins.
This project aims to study the seafloor imprint of DSWC using high-resolution field data and interdisciplinary concepts. The primary focus will be on multibeam bathymetry data sets from 6 areas affected by DSWC. 8 leading research institutions committed to provide the data required. The main expected results are: 1) a better understanding of the physical processes involved in the propagation of DSWC flows, 2) a quantification of their capacity to erode and deposit sediment, and 3) a characterization of the sensitivity of DSWC formation and distribution to climate change in Polar Regions. The host institution expertise on the links between ice sheet dynamics, climate change and marine geological records will be crucial for the training of the applicant and for the success of the project. The planned secondment will add a numerical modelling component so that an in-depth knowledge of the physical processes involved in the propagation of DSWC is achieved. This pioneering work will extend European leadership in the study of DSWC, address EU challenges in the Horizon 2020 programme, and be of interest to industries exploring for natural resources. The project represents an extraordinary opportunity for the applicant to develop technically and professionally.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195759;659288;TADFORCE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Strengthening and survey beyond the knowledge of the TADF emitters as materials for superefficient OLED devices;1/05/2015;30/04/2017;;"The OLED worldwide market is growing rapidly and Europe needs experts possessing a comprehensive knowledge and practical experience in this technology. OLED technology is used in small devices such as smart phones and tablets but also in high-end TVs and lighting, as OLEDs are still relatively expensive compared to LCD. But with research progressing towards lower cost and longer lifetime, together with a growing trend to use flexible displays in smartphones etc., the OLED market is growing fast. Europe is a huge supplier of the materials for OLED displays, taking in to account that electronic market is changing very fast and companies are search for new cheaper materials the input of research in this area is needed. The flexible OLED display market is predicted to quadruple next year, with predicted global market revenue for flexible OLEDs to increase from $21.9 million in 2013 to $12 billion by 2020 and this project will help to maintain Europe place as a major supplier of OLED materials.
The high demand for flexible OLEDs will increase the need for very expensive and rare iridium. The TADFORCE project aims to explore exciplex emitters and thermally activated delayed fluorescence (TADF) in OLEDs i) to replace currently used Ir complexes, and ii) to show how to easily tune emitter, resulting in reduced production cost, especially blue, where Ir based emitters fails.
The main research goal of the multi-disciplinary TADFORCE project is to explore CT and exciplex emitters and their application in OLED devices by training Experienced Researcher through joint research in chemical, physical and material science in both academia and industry.
The ER will gain experience in conducting research in a multidisciplinary environment to produce important data in this new OLED field to enable the development, modeling and tailoring of TADF OLED devices, which are at the forefront of new OLED research and development.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Durham;UK;;; 195794;659453;DINO_DON;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Does vegetation derived organic nitrogen fuel algal blooms in coastal waters of the Baltic Sea?;1/01/2016;31/12/2017;;"Shallow coastal waters in the Baltic Sea, rich in organic matter, are threatened by toxic dinoflagellates blooms, which have deleterious effect on human health and aquatic life. The toxic Alexandrium ostenfeldii blooms in coastal waters where vegetation start to decompose in late summer and release dissolved organic nitrogen (DON). Dinoflagellates are potentially mixotrophic; they are photosynthetic and can use DON. However, the mixotrophic activity for Alexandrium in the Baltic Sea is unknown. The issue will be addressed using stable isotope 15N tracer experiments with enriched substrates from decaying vegetation and visualization of N incorporation pathway (direct uptake or via bacteria) in individual cells using NanoSIMS to determine the mixotrophic capacity of Alexandrium from different geographical sites in the Baltic Sea that differ in vegetation cover and type. A difference in adaptation to N sources may further support the genetic differentiation shown between Alexandrium populations in different areas of the Baltic Sea. The project will provide new understanding to nutritional physiological ecology of toxic dinoflagellates. Our aim is to understand if DON from decaying vegetation can be a source of N for toxic Alexandrium blooms in the Baltic Sea. By matching vegetation and habitat variables with Alexandrium bloom occurrence and mixotrophic activity we will develop a tool to identify potential bloom sites of Alexandrium in shallow coastal waters and to make recommendations for local management. If the application is accepted as IF the training in population genetics and spatial modelling using A. ostenfeldii as a model species, will be a key step for the development of the applicant in light of the research objectives towards modelling how metabolic activity differs with different populations.";191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SUOMEN YMPARISTOKESKUS;FI;;; 195726;659130;VesSenDrugDeliv;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A versatile platform for the design of targeting drug delivery vesicles;1/07/2015;30/06/2017;;In the project of Marie Sklodowska-Curie Fellowship, I will design a versatile molecular platform that is used to construct multifunctional amphiphiles, which co-assemble with amphiphilic gold nanoparticles (AuNPs) to form monodisperse and stable targeting drug delivery vesicles. By incorporating multiple targeting ligands and multiple hydrophilic and hydrophobic drugs, I aim to discover efficient vesicle formulation with increased targeting selectivity and potent cytotoxicity to tumor cells. The route of the targeted drug delivery will be followed spontaneously via transiting surface plasmon resonance of AuNPs, and the impact of the targeted drug delivery on the targeted tumor cells will be monitored in real time by live cell Raman micro-spectroscopy. Furthermore, any targeting ligand, hydrophilic and hydrophobic drug can be easily tuned for a variety of different targeted tumour cells.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195731;659152;GLDAFRICA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;GLOBAL BIODIVERSITY LEGUME ASSESSMENTS IN AFRICA: WEST CENTRAL AFRICA AS A CASE STUDY;15/10/2015;14/10/2017;;Despite being one of the most biologically diverse habitats on the planet, the description of tropical rain forests and the understanding of their evolutionary history are far from complete. Furthermore, there is an increasing need for assessing global biodiversity changes especially in tropical rainforests, due to their role as global biodiversity repositories. West Central Africa represents the area of greatest biodiversity richness within tropical Africa and with the highest percentage of untouched pristine forest for the whole of Africa and Madagascar. West Central African biodiversity not only faces the challenges of climate change, but also human pressure with the highest population growth rates in the world. This project will contribute to the ongoing Global Legume Diversity Assessment programme, that is being developed to improve our understanding of biodiversity loss using legumes, the third largest family of angiosperms, as a proxy. The project will focus on tribe Detarieae, which are the dominant component of West Central African forests, and thus an ideal exemplar clade for the proposed study. The project aims at reconstructing phylogenetic relationships within Detarieae and produce a temporal framework for the diversification of the group. The phylogenetic diversity patterns will be investigated to identify hotspots of recent speciation and evolutionary diversity and their correlation with land use changes, biodiversity loss, and extinction risks. The project also includes a full IUCN conservation assessment for all studied species, thus obtaining an indication of survivability for Detarieae in West Central Africa under climate change while considering different emission scenarios proposed by the Intergovernmental Panel on Climate Change (IPCC). Given that the legume family has been shown to be a good proxy for botanical diversity in general, the results obtained here will be invaluable for the preservation of biodiversity in this region of the world.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL BOTANIC GARDENS KEW;UK;;; 195810;659545;STEPDYN;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;H2 and CH4 Dissociation Dynamics on Stepped Metal Surfaces via First-Principles Simulations;1/09/2016;31/08/2018;;"With STEPDYN I propose to achieve for the first time an accurate theoretical and computational modelling of the reactive scattering of small molecules on stepped metal surfaces. The aim is to close the material gap in our fundamental understanding of heterogeneous catalytic processes at the gas/solid interface, since stepped surfaces are close models of the active sites of catalyst particles. Specifically, I will focus on two processes:
(i) dissociation of H2 on the stepped surface (211) of copper: H2/Cu(211)
(ii) dissociation of CH4 on the stepped surface (211) of nickel: CH4/Ni(211)
Both are activated dissociation processes of great importance for heterogeneous catalysis in the energy field (they are linked to methanol, methane and H2 processing). Using appropriate specific-reaction-parameter (SRP) density-functional theory for the systems of interest I will: (i) construct 6-dimensional potential energy surfaces and use them in quantum dynamics of H2/Cu(211), (ii) employ ab-initio Molecular Dynamics with a semi-classical description of nuclear motion for CH4/Ni(211). Possible methodological issues associated with structural degrees of freedom and anisotropy, localized electronic states, etc. will be systematically explored.
This will be achieved in a MC fellowship during which I will:
(i) work in an internationally recognized and scientifically stimulating group, leader in modeling molecular reactive scattering on metallic surfaces
(ii) further and deepen my knowledge in scattering approaches to heterogeneous catalysis, grounding on what I matured in a 9-months visit during my PhD.
(iii) combine it with my post-doc expertise in theoretical catalysis ,
(iv) face a challenging but important project requiring new methods, thus maturing my researchers skills
(v) advance my career and become one of the experts in this field
In tune with the objectives of the MC program both scientific achievements and personal advancement are aimed at within STEP";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT LEIDEN;NL;;; 195812;659553;SCIL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;The role of social cues for infant word learning;1/04/2016;31/03/2019;;Infants start knowing the meaning of some words by 6 months of age and by age two they know hundreds. The mechanisms behind the word learning processes subtending these feats are still poorly understood. Current accounts of infants word learning differ about the degree to which word learning is purely a product of increasingly sophisticated perceptual associations, versus a process in which associative learning is implicated, but the main engine of development is fundamentally social and timed by the infants grasp of the referential intentions of others when using language. The present project will explore the mechanisms behind word learning (1) by identifying the elements that lead to a word learning advantage in a social situation, (2) by assessing whether infants infer intention from social cues, or whether the latter merely refocus attention, and (3) by testing how long-term word learning is modulated by social cues in naturalistic situations. By assessing both infants (aged 6-10 months) and toddlers (aged 12-16 months), I will determine whether the mechanisms for word learning change with age. I will be able to characterize the role of social cues in young infants and toddlers' word learning for the first time by leveraging the cutting-edge technologies of gaze-contingent eye-tracking and infant-friendly automated toys.;246668,4;246668,4;H2020-MSCA-IF-2014;MSCA-IF-GF;ECOLE NORMALE SUPERIEURE;FR;;; 195893;660125;ORSETOSY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Organocatalysis at the service of total synthesis: Madangamine alkaloids;27/04/2015;26/04/2017;;This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the madangamine alkaloids B, C and E based on a novel organocatalytic desymmetrization reaction as a key step, which will allow the rapid and efficient construction of the BC rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different madangamines and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development via organocatalysis and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195680;658884;Eco-LWG;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Eco-lightweight granules for energy efficient applications;1/08/2015;31/07/2017;;"Buildings in Europe are responsible for more than 40% of total energy consumption and 25% of carbon emissions, mainly due to the high number of old housing stock with very poor insulation systems. This research will develop new energy efficient materials by engineering eco-lightweight granules (eco-LWG) to mitigate these problems. The eco-LWG will have high strength and high water absorption, ~100 wt.%, and be made from widely available waste materials: recycled mixed coloured glass, clay and limestone. The eco-LWG will be used to contain phase change materials (PCM), which use chemical bonds to store and release heat, allowing control of temperature fluctuations. The high level of porosity in the eco-LWG will allow them to absorb and retain much higher levels of PCM than has previously been possible using existing lightweight aggregates. Both the eco-LWG and the PCM loaded eco-LWG will be optimised by statistical design methodology and they will be used to develop new energy efficient construction products. Two impregnation methods will be compared to introduce the PCM into the eco-LWG: vacuum sorption to achieve maximum PCM uptake and short term immersion to partially fill the connected porosity. These will produce innovative lightweight and high heat-storage materials. Incorporating PCM loaded granules in mortars and other construction materials will result in reduced energy requirements to heat and cool buildings and improve indoor living conditions.
The eco-LWG developed in this research will also be used in green roofs to provide water retention capacity and slow nutrient release. Green roofs can reduce the energy requirements of buildings and urban pollution. This multidisciplinary innovative research will deliver new energy efficient construction materials that can contribute to achieving the 2020 target of nearly zero-energy and highly material efficient buildings, which is an essential target to achieve sustainable growth in the EU.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195711;659046;MACROIMAGING;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Specific Fluorogenic Peptides for Imaging Metastasis-associated Macrophages;1/10/2015;30/09/2017;;"MACROIMAGING is a highly interdisciplinary project encompassing the preparation and optimisation of innovative fluorogenic imaging tools with high selectivity for metastasis-associated macrophages.
The metastatic potential of tumours is defined by the tumour microenvironment (TM), where macrophages are the most abundant cells. However, the role of macrophages in the TM remains elusive mainly because of the lack of technologies to target these unique populations of cells in vivo. CD11b\ metastasis-associated macrophages are recruited by metastasing cancer cells. Their depletion reduces the number and size of metastasis, suggesting that their recruitment is essential for persistent growth of cancer cells. However, there is a need for imaging tools that report the localisation and cell fate of these macrophages to understand how they help tumour cells to progress in the TM.
By means of Dynamic Combinatorial Chemistry, libraries of cyclic peptides will be generated from individual tetrapeptides through reversible disulfide bonds. Governed by thermodynamics, DCC will amplify cyclic peptides showing high affinity for CD11b\ macrophage receptors, involved in the development of metastasis. This technique will supply specific cyclic peptides targeting CD11b. Click chemistry (i.e. CuAAC) will allow the conjugation of these peptides to macrophage-specific fluorophores to generate FLUOROMACS. FLUOROMACS will enable selective imaging of CD11b\ macrophages by means of receptor-mediated endocytosis. Selectivity will be confirmed in vitro using macrophages from normal cohorts and knockouts. Finally Fluoromacs will be optimised as in vivo imaging probes for metastasis-associated macrophages.
In a nutshell, MACROIMAGING will provide the first generation of chemical probes for imaging metastasis-associated macrophages in vivo. This methodology will also have enormous impact in other areas of chemical biology, such as protein recognition, drug discovery and theranostics.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195757;659232;MIM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Enhancing Motion Interaction through Music Performance;4/01/2016;3/01/2019;;The proposed project aims to enhance Human MotionComputer Interaction by leveraging on a multidisciplinary approach between experimental psychology, music technology and computational modelling. Firstly, the project looks at skilled activities, in particular music performance, in order to understand fundamental cognitive and psychological aspects of control and expression in human motion. The project involves computational models of motor control and expressive variations built from music performance data collected during psychophysical studies. Secondly, the project broaches the implementation of these models in Digital Musical Instruments (DMI), thus creating a new type of digital instrument based on sensorimotor learning mechanisms. The resulting DMI is then assessed through a user study in which elements of exploration and engagement will be tested over several sessions. Therefore, the project contributes to two main uncharted research areas. Firstly it contributes to the fundamental understanding of sensorimotor learning processes by considering complex human motion, specifically motion in music performance. Secondly, it represents an original application of computational modelling by modelling expressive musical gestures and transferring these models to interactive systems.;232160,4;232160,4;H2020-MSCA-IF-2014;MSCA-IF-GF;INSTITUT DE RECHERCHE ET DE COORDINATION ACOUSTIQUE MUSIQUE - IRCAM;FR;;; 195672;658853;HiPerMeGaFlowS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High-Performance Curved Meshing and Unstructured High-Order Galerkin Solvers for High-Fidelity Flow Simulation;1/04/2015;31/03/2017;;High-fidelity flow simulation is one of the main goals to pursue in the research towards exascale computing. This capability will allow a cheaper exploration of aeronautical and automotive designs that fulfill energy consumption and noise emissions policies of the European agencies. In this project, the integration of three high-performance tools will be studied as a promising alternative to perform high-fidelity flow simulations. Specifically, a parallel curved unstructured mesh generator will be integrated with two different parallel high-order stabilized Galerkin solvers. We expect that the novel research on the development and combination of these high-performance tools will provide the physical, numerical, and geometrical accuracy required to perform high-fidelity flow simulations on complex domains defined by industrial computer-aided design models. Furthermore, the project is of major interest in high-performance computing since we expect to improve the scalability of implicit flow solvers by increasing the accuracy for a given computational cost, favoring computation to data transfer, and increasing the ratio of operations that scale linearly with the number of mesh elements. The combined tools will be deployed in a large cluster to obtain flow simulations of practical interest for the aeronautical and automotive industries.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;ES;;; 195716;659082;AFIBROTIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Atrial Fibrillation, Fibrosis and Rotors: New Insights from Imaging and Computational Modeling;1/10/2015;30/09/2017;;"Atrial fibrillation (AF) is the most common type of arrhythmia and causes substantial morbidity and mortality. AF is principally treated with catheter ablation. Unfortunately, the mechanisms that initiate and sustain the arrhythmia are still incompletely understood and, as such, ablation remains a highly operator-dependent procedure with low success rates. Two recent studies promise to lead to better ablation outcomes, showing that a) the amount of atrial fibrosis directly correlates with the non-responsiveness to ablation and that b) AF is maintained by electrical rotors and targeting their suppression improves the success rates. Nonetheless, the lack of a rigorous mechanistic framework of AF pathophysiology deprives those studies of solid fundaments so that their effective value is still debated.

This project aims therefore to provide such a framework by exploiting advanced biomedical engineering concepts. The focus will be on explaining and connecting recent experimental findings about fibrosis and rotors. The relationship will be first analyzed in vivo from AF patient data acquired with state-of-the-art instrumentation in the field of interventional electrophysiology. Measured data will be then integrated within a multi-scale personalized computational model of the fibrillating atrium that will determine, on a patient-specific basis, the mechanistic connection between fibrosis and reentries. Furthermore, the tool will provide an in silico environment for personalized ablation planning. Key in the project will be the synergy between complementary state-of-the-art expertise in the fields of medical imaging and computational modeling provided by applicant and host institutions. All partners will strongly benefit from the implied two way knowledge transfer, in terms of career advancement (the applicant) and enlarged network/grant proposal opportunities. The study will foster more focused clinical research aiming at better treatment for the AF patients.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;IT;;; 195754;659233;Photovitamin Windows;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Microprocessing photovitamin D3 using photo-high-T intensification.;1/09/2015;31/08/2017;;"This project develops a continuous flow microprocess for the synthesis of pure vitamin D3 from 7-dehydrocholesterol. Such approach will be achieved by applying a massive and combined photo-high-T intensification. Such conditions are only possible by employing microreactors according to Novel Process Windows postulates: The aim is to boost the reaction kinetics both by providing a high photon number density and through thermal intensification. In addition, supercritical conditions will be tested as third intensification option. Besides the normal time-invariant, continuous photon exposure, a new photochemical approach based on intense LED-photo-pulses will be tested to enhance the selectivity. To have a full process scheme covered, a continuous micro-plug-flow crystallization operating at fast mixing, short residence time and supersaturated conditions will be developed.
Vitamin D3 is a very important nutrient needed to prevent all types of disease. As its deficiency is now recognized in the developed world, a significant increase demand in the market is expected. That is why it is envisaged a multiple impact of this project mainly in European society, but also for pharmaceutical companies and SMEs, representing for both a Window of Opportunity. Particularly photo-high-T could be also tested in other photochemical reactions; such as the synthesis of vitamin D2 or, by using other photocatalysts such as TiO2, in the N-ethylation of benzylamine.
This multidisciplinary proposal includes Life-Cycle-Assessment (LCA) to holistically evaluate in ex-ante fashion different process intensification scenarios. At the project end, LCA will benchmark the flow achievements to the current batch production, looking towards its industrial transfer. For the fellow, this proposal means an extension of his previous research, but with novel and challenging additional aspects,providing with a range of training options in research and transferable skills for building his independent career.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;TECHNISCHE UNIVERSITEIT EINDHOVEN;NL;;; 195779;659376;ssmscaifa;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Making of Modernist Resistance, 1880-1950;1/09/2015;31/08/2017;;The vibrant diversity of an increasingly global modernity owes much to the cross-cultural exchanges between British and Indian modernists during their collaborations in civil rights, anti-colonial, and anti-fascist activism from the 1880s to the 1950s. The proposed project examines the shifting nature of literary and political contributions to activist movements made by four such networks of British and Indian modernists to illuminate their integral role in creating what I contend is a distinctively modernist resistance. As early as the 1880s, theosophists from Britain partnered with renowned Indian spiritualists to bridge cultural gaps between colonizer and colonized through shared mystical experiences to emphasize an innate unity among human beings. By 1919, however, the disillusionment following World War I coupled with Indias outrage about the Amritsar Massacre in which General Dyer and his troops opened fire killing hundreds of innocent Indians, supplanted such yearnings for unity with efforts to protect democratic freedoms from threats by right-wing extremists through a secular socialist resistance. Mulk Raj Anand, initially drawn to the liberal humanism of the Bloomsbury Group eventually joined the radical socialists of Indias Progressive Writers Association in 1936. Women like Sarojini Naidu and Virginia Woolf fought for womens equality and opportunities to join in anti-right-wing resistance. Mahatma Gandhi and Jawaharlal Nehru, influenced by the socialist ideologies of the Fabian Society, incorporated them into Indian nationalism and governance. This study explores the relationship between the ideologies of these networks to establish what the shift from spiritualism to secular socialist nationalism reveals about the nature of modernist resistance and the conditions of modernity that inspired it. The world view underpinning this resistance was integral in defining the post-war identities of Britain and India as secular socialist-leaning democracies.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195696;658989;LeGaNa;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Leggett-Garg test of a vibrating carbon nanotube;1/03/2016;28/02/2018;;Despite the undeniable success of quantum mechanics, the boundary between quantum and classical mechanics remains unclear. Leggett and Garg devised a class of inequalities that provide the script for a quantitative test to determine whether a macroscopic object would indeed be at all times in one of its distinct states or whether quantum mechanics would prevail. I will perform the first Leggett-Garg test on a massive moving object: a carbon nanotube resonator. This ambitious experiment would be a key accomplishment in mapping the persistence of quantum features in systems of increasing macroscopicity.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195688;658932;TWISTER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ToWards the Identification of Sesquiterpene TransportERs;1/08/2015;31/07/2017;;"Plants synthesize a wide range of secondary metabolites, among them, terpenes. These molecules are notably produced in trichomes which are specialized structures present on the surface of aerial organs. Although the terpene biosynthetic pathways have been well deciphered, their transport across membranes remains poorly understood. This is for instance the case for sesquiterpenes such as artemisinin, an extremely potent anti-malaria drug. Despite the immense benefits of these compounds for plant defenses as well as for human health, no sesquiterpene transporters have yet been identified.
It was recently shown that Pleiotropic Drug Resistance (PDR) transporters, which belong to the large ATP-Binding Cassette family, are involved in diterpene transport in Nicotiana tabacum trichomes. Thus, other PDR transporters could transport other types of terpenes such as sesquiterpenes.
Recently, two PDR transporters of Artemisia annua, namely AaPDR1 and AaPDR2, have been shown to be specifically expressed in glandular and T-shaped trichomes, respectively. Interestingly, glandular trichomes are known to produce artemisinin while T-shaped trichomes have been shown to produce -caryophyllene. Thus, we can hypothesize that AaPDR1 and AaPDR2 transport dihydroartemisinic acid, the artemisinin precursor, and -caryophyllene, respectively.
In order to examine this hypothesis, this project aims to express these transporters in N. tabacum BY2 cells and characterize their activity using toxicity and transport assays in whole cells as well as direct transport in plasma membrane vesicles. In case our hypothesis concerning the substrates is incorrect, we will rely on a transportomics approach, which consists of running transport assays using metabolites extracted from isolated trichomes as putative substrates. In parallel, as a side project, isolated glandular and T-shaped trichomes will be submitted to quantitative proteomic comparison in order to identify their respective metabolisms.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CATHOLIQUE DE LOUVAIN;BE;;; 195797;659466;NEOMEDPOT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Technological change at the South-western limits of the Mediterranean basin during Neolithic and early Chalcolithic times: pottery production and consumption;1/10/2015;30/09/2017;;"This project examines the radical social changes which took place in the South-western Mediterranean basin during the Neolithic and the beginning of the Chalcolithic period, and specifically the interactions between North Africa and the southern coast of the Iberian Peninsula across the Straits of Gibraltar. It takes an explicit technological approach informed by Material Culture Studies which uses the reconstruction of the craft of pottery manufacture to inform our understanding of social transformation.It comprises the first research programme focused in pottery analysis across a wide area of study, including North African and European production, the first of which remains mostly unknown until now.
The methodology employed is an integrated approach based on instrumental analysis of pots (optical petrography and SEM), including morphological, ornamental and functional characterization of ceramic products; as well as the comparison of ceramic fabrics with potential raw materials in the study areas.
A number of key archaeological questions are addressed in this way. The time period considered sees changes in food production, along with increased sedentism and specialization in craft production of ornaments. While Neolithic cultures have often been defined according to their pottery and their stylistic groups, it is the technological traditions associated to them will allow us to explore mechanisms of knowledge transmission and innovation, labour organization and the construction of exchange networks. These are all key aspects which allow us to explore the links between technological change and the social change in the human communities in the area in study, at a time when semi-nomadic groups adapt to sedentary ways of life with the emergence of social asymmetry and labour specialization in the early Chalcolithic.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195656;658838;STOICHIOMET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Blending Stoichiometric and Metabolic Theories from Genes to Populations: Resource Stochiometry and Temperature Effects on Consumers with Contrasting Life-history Strategies;12/10/2015;11/10/2017;;"Human-induced global warming and increased nutrient bioavailability are impacting on species evolution and ecosystem functioning worldwide. Single effects of each global change factor on consumer life history have been well assessed by the metabolic theory of ecology, and ecological and biological stoichiometry, respectively, and for each biological level from genes to populations. However, their potential consequences when both interact remain elusive because of the non-additive nature of their effects. STOICHIOMET project proposes to (i) study the single and interactive effects of temperature and nutrients in food on consumer performance; and (ii) test simultaneously cornerstone concepts of both metabolic (Bergman rule) and stoichiometric theories (growth rate hypothesis; phosphorus-allocation hypothesis). To aim these, a field survey and coupled growth bioassays, following 4 (temperature) ? 4 (elemental dietary composition) experimental designs, will be conducted. Consumer growth response of selected model species (Chlamydomonas, Selenastrum, Brachionus, Diaptomus, Daphnia, Drosophila) will be measured at each level in terms of: ribosomal DNA genes and intergenic spacers; genome size; nucleic acid and protein content; cell size; body size and elemental composition; and growth rates. Additional data treatment will be performed to model growth rate and coupled variables as functions of body size, temperature and resource stoichiometry, and hence, theoretically integrate metabolic and stoichiometric conceptual frameworks. Multidisciplinarity of STOICHIOMET project, interrelating genetics, biochemistry, metabolism, ecology and evolution knowledge, will contribute to the scientific development of PhD Bullejos, and together with its training programme, will favour his future re-establishment. In addition, STOICHIOMET project represents an unique opportunity to create a network among researchers from different knowledge areas and excellent European institutions.";196400,4;196400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITETET I OSLO;NO;;; 195750;659213;LIVING LASERS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Living cell lasers: intracellular lasing induced by natural and polymeric microscopic resonators;1/08/2015;31/07/2017;;"Can a living cell be turned into a laser? By aiming to coalesce biological cells with laser light, the most versatile tool that modern photonics has developed, LIVING LASERS explores entirely new ways to develop fully biocompatible lasers.

The ability of vitamins, bacteria and even living cells to generate laser light has been recently demonstrated by the supervisor of the project, Prof Malte Gather. However, these and other experiments with active biological gain media are so far limited by the rigid and synthetic nature of the optical resonators, an essential part of any laser device. Introducing lasing in living cells independent of external resonators necessitates a conceptual change of the laser design. This is realized by internalization of microscopic resonators that will transfer the optical feedback directly into the cell. It is the main goal of this interdisciplinary project, located at the interface between material sciences, laser physics, photonics and biology, to demonstrate autonomous single cell lasing. Consequently, LIVING LASERS can be expected to start a whole new field in biophotonics and will help to overcome the boundaries between living nature and nowadays highly artificial and harmful laser technologies.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;;; 195795;659454;REAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Real-time diagnostics for Enabling Advanced laser-based roll to roll materials Processing;1/07/2015;30/06/2017;;An experienced researcher with laboratory expertise in real time monitoring of laser-matter-ambient-interactions will be diversified towards scalable production which is desperately needed to fully realise the potential of high repetition rate, multi-kiloWatt, femtosecond and picoseconds laser technologies. The fabrication of integrated multifunctional thin film devices by additive (inkjet, spray) and subtractive (laser) manufacturing on Roll to Roll (R2R) production platforms is also suddenly possible and desperately needed to transform the competitiveness of Europes SME manufacturing sector. The training programme will lead to scalable innovation by developing diagnostics for ultra-precision laser processes. The initial objective of the project is to identify which intersecting value chains for real time or in-line diagnostics can fully realise the potential of short pulse laser structuring. Three diagnostics based on gated (i) spectral analysis of laser generated plasma plumes, (ii) image analysis of laser material ambient interactions and (iii) laser induced breakdown spectroscopy will be developed. The Fellow will demonstrate two process diagnostics using the R2R pilot line at the industry site. The application of these on-line tools will create pathways for cost effective production based on new nano-inspired materials relevant to flexible large area electronics. The multi-partner training environment provides excellent facilities for the talented ambitious Fellow. Over 30\ researchers will be directly impacted by the project. An active programme of knowledge transfer and information dissemination is also proposed based on industrial workshop, active conference participation, journal publications, and science promotion.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;;; 195673;658855;OptiMADMix;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Optimized Mesophilic Anaerobic Digestion Mixing;5/01/2016;4/01/2018;;"The aim of this innovative Fellowship is to provide a robust numerical framework, based on novel developments in the fields of CFD and biokinetic modelling, to optimize mesophilic anaerobic digester (MAD) performance, by reducing energy consumption whilst maximising biogas production.
By 2030 the world will have to produce 50% more food and energy and 30% more water. Consequently, most countries are implementing programs to reduce carbon emissions and enhance renewable energy production.
MAD is the most widespread technology for the treatment of sewage sludge, the by-product of sewage treatment. This natural process uses bacteria to break down biodegradable material and produces a biogas rich in methane. The current drive to maximise energy recovery means that biogas from MAD is increasingly harnessed by combined heat and power technology. Thus, there exists the need to optimise digester performance to maximize energy recovery.
The benefits of improved performance go beyond CO2 reductions, as they will facilitate environmental improvements, reduce operating costs and improve the financial performance of the European and global wastewater industry. The challenge is to improve digester control to minimize excessive mixing, so eliminating additional, unnecessary environmental and financial costs whilst maximising biogas output.
We will simulate for the first time the complex relationships between hydrodynamic and microbiological processes in a MAD environment, whilst also recognising the potential for grit sedimentation within digesters. We will extend significantly previous work and use coupled CFD/MAD modelling as an innovative and robust technique to monitor and control the hydraulic and biochemical performance of MAD.
Meeting the project aim will deliver an appropriate methodology to improve MAD design and control, thereby offering tangible environmental and financial benefits and assisting the meeting of EU Directive requirements.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195782;659391;SELECT-A-PROTEIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mixed brushes of stimuli-responsive polymers for the selective adsorption of proteins;1/10/2015;30/09/2017;;"Advanced materials are at the heart of many scientific fields, particularly in the biomedical and biotechnological areas. Many devices (e.g., biosensors, implants, catheters, and systems for drug delivery) would benefit from an effective control over molecular and cellular interactions at material surfaces. Main challenges in this field include the control of biomolecules (e.g., proteins, DNA) adsorption on different surfaces. Designing surfaces that allow proteins to be adsorbed in a controlled manner is particularly important and challenging. Many strategies were recently developed to spatially or temporally control protein adsorption.
In this project, a novel strategy for selective protein adsorption from a mixture of proteins will be developed. This strategy will be based on the use of mixed polymer brushes sensitive to ionic strength and pH of the surrounding medium. The project rests on the following steps:
i. The design of mixed polymer brushes whose properties will be tuned by adjusting pH and ionic strength of the medium. The influence of polymer properties (molecular weight, and degree of dissociation and conformation through pH and ionic strength variations) on protein adsorption will be studied.
ii. The development of a procedure, based on time-of-flight secondary ion mass spectrometry (ToF-SIMS), to distinguish different proteins adsorbed together on model interfaces.
iii. The use of this ToF-SIMS-based procedure to investigate the potential of the created mixed brushes to selectively adsorb one protein, at first from a mixture of two or three proteins, and then from a more complex medium.
The results obtained in this work will be significant for material science and biomedical applications through the development of a robust procedure to prepare smart surfaces with novel properties to control protein adsorption.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CATHOLIQUE DE LOUVAIN;BE;;; 195739;659191;PHLOEMAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hydraulic functional traits as determinants of forest function and drought responses. Putting xylem and phloem attributes into the functional trait map.;15/01/2016;14/01/2018;;Forests provide key ecological services such as the regulation of energy, carbon and water balances from local to global scale. These are however under severe pressure due to climate and land use changes, especially in the Mediterranean basin where limited water availability is prominent. It is thus crucial to identify the forest species and areas that are likely to be more vulnerable to reduced water availability and establish how changes in forest composition and structure will impact key ecosystem services. In this project, we will use the functional trait concept to bridge between tree, population, species and forest level and as such enlarge our capacity to predict where and when dramatic changes in forest ecosystem services are likely to occur, especially focusing on the role of phloem and parenchyma tissue in tree and forest functioning in relation to drought. Our objectives are to (i) measure phloem and parenchyma traits of 104 populations of 7 dominant tree species in Catalonia and Portugal, study the relationships between these traits and other hydraulic and functional traits and quantify their variability along gradients in water availability, (ii) integrate phloem and parenchyma traits in the theoretical framework describing tree responses to drought, (iii) determine which combination of traits is the best predictor of drought resistance at intra- and interspecific level and (iv) test how and to which extent variability in phloem and parenchyma traits influences forest performance at different ecological scales and forest vulnerability under climate change scenarios. Classical wood anatomy and plant physiology methods will be used as well as novel 3D techniques and recently developed models will be combined and extended. Our results will contribute to the knowledge needed to design effective strategies to deal with climate change. Transferring it to managers and policy makers, as well as to the society at large, is thus a focus of the proposal.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRO DE INVESTIGACION ECOLOGICA YAPLICACIONES FORESTALES;ES;;; 195642;658705;NEW4NEW;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New methods for new materials;1/04/2015;31/03/2017;;"Computational modelling of molecules and materials has had a great impact on understanding experimental observations and suggesting new routes for development. A prominent example are chemical reactions where modelling allows one to follow the motion of atoms and to obtain a detailed insight into the process.
To model chemical reactions, quantum mechanics for electrons is needed and currently the most widely used method for this task is Kohn-Sham density functional theory (DFT). DFT is exact in principle, but in practice, different approximations are made. These approximations affect the accuracy of description of both strong intramolecular forces (chemical bonds) and weaker intermolecular interactions (e.g., van der Waals forces). If the errors are significant, one can obtain misleading results.

Systems where an accurate description of both strong and weak forces is crucial are molecules in porous materials, such as zeolites.
Zeolites are important industrial catalysts and also perspective materials for gas separation. During the catalytic process, molecules interact first weakly with the zeolite before chemical reaction takes place.
Therefore, if we want to further improve the function of porous materials or develop new ones with desired chemical activity, we need to be able to model reliably both strong and weak forces.

It is the goal of this project to develop new reliable methods that will enable the development of new materials. This goal will be accomplished by combining state-of-the-art DFT approximations for modelling strong and weak interactions and implementing promising schemes recently proposed.
Using the expertise of the host group, we will use data available for zeolites and molecules in zeolites to validate the methods and understand their accuracy.
The ability to model reliably processes in porous materials will have a large impact on the development of materials in a range of fields, including materials for solving future energy needs.";154720,8;154720,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;USTAV FYZIKALNI CHEMIE J. HEYROVSKEHO AV CR, v. v. i.;CZ;;; 195858;659910;PBIGP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Plant-Bacillus Interaction: Gain of Function Project;17/03/2016;16/03/2018;;"New and sustainable methods must be developed to meet societys ever-increasing demand for food, energy, and chemicals. Feeding tomorrows population requires increasing food production sustainably and developing novel approaches to invert the excessive consumption growth of fertilizers, pesticides, and irrigation-water by modern agriculture. Fortunately, symbiotic or non-symbiotic interactions between plant-hosts and specific microbes were shown to promote host-vigor, and improved product quality and yield and plant-growth-promoting bacilli have been commercialized as biofertilizers in recent years. However those benefits associated to the PGPRs are divided across a large diversity of bacteria; and host-plants demands, nutrient availability, and pathogen attacks vary constantly during the entire plant lifespan.
The proposed research project for the H2020-MSCA-IF-2014 will focus on identifying, validating, and stacking bacterial gene clusters responsible of those properties. The approach consists of establishing libraries of hybrid-bacillus and screening them for novel plant growth promoting properties. Because of the current importance of reducing inputs in agriculture while increasing crop yield; the screen will focus on identifying properties that allows decreasing use of chemical fertilizers such nitrogen and phosphorus and improve drought and salt tolerance. The proposed research intertwines fundamental and applied fields and is designed to seed larger projects toward a sustainable agriculture and feed tomorrows population. It is designed to increase our knowledge in plant-microbe interactions, result in discoveries, and generate innovative technologies.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195744;659226;GLASSIX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Improved metallic GLASses for Small Implants through X-ray and biological characterisation of corrosion products;2/11/2015;1/11/2017;;Small metal implants such as dental implants or bone-anchored hearing aids need very good mechanical properties and corrosion resistance to avoid local inflammation and remain integrated in bone. In GLASSIX, Ti-based metallic glasses will be developed specifically for small implants using a new approach to evaluate biocompatibility. This is usually tested on passive metal surfaces, but recent work has shown that mechanically-assisted crevice corrosion (MACC) can generate metal particles and corrosion products that damage the surrounding tissue. In situ characterisation of corrosion products with synchrotron X-rays will be used to design standard simulated corrosion products that will then be tested on human cells to evaluate which corrosion products are most damaging. The findings from this new approach will be fed back into the alloy development process together with information on feasibility of manufacture from Anthogyr, a leading manufacturer. The project combines the ERs expertise in metallic glasses, and the expertise of host researchers in corrosion, X-ray methods, clinical and biomedical research, and will equip the ER to carry out cutting edge research in an academic environment that can readily be translated into clinical and commercial success in the biomedical devices sector.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195878;660039;PHAGECOM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Complex parasite communities as drivers of bacterial immunity;1/01/2016;31/12/2017;;"CRISPR-Cas is one of several distinct bacterial defence mechanisms that provide immunity against viruses (phages) and other mobile genetic elements (MGEs; e.g. plasmids). My research aims at understanding how CRISPR-Cas-mediated immunity is affected by the complexity of MGE communities. Using evolution assays and deep sequencing techniques I aim to study (i) the evolution of CRISPR-Cas-mediated immunity in a complex MGE community (i.e. multiple phages and plasmids), and (ii) determine the associated co-evolutionary dynamics. The proposed research is highly multidisciplinary and will perfectly complement my background in biochemistry and molecular biology. It also allows me to establish collaborations with academic and industrial partners to realize applications in dairy industry and phage therapy. The project will be pivotal for my personal development to become an independent researcher and offers me the unique opportunity to work in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter. Biosciences is a leading institute in evolutionary biology, microbiology and ecology that provides excellent opportunities for academic training and personal career development. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my own background, offering exciting opportunities for knowledge exchange and will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures for the general public throughout 2015 (the Year of the Phage) to emphasize the importance of phage research for many aspects of our society, including industry and medicine.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EXETER;UK;;; 195736;659175;Magnetic HEART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Targeting the Human Myocardial Remodeling Process Using Novel Magnetic Force-Based Human Heart Tissue;1/09/2016;31/08/2018;;"Cardiovascular diseases are responsible for the greatest proportion of deaths in people under the age of 70 and cost the EU 110 billion each year. A major cause of heart dysfunction following myocardial infarction is the extensive remodeling of the extracellular matrix (ECM), which leads to the formation of fibrotic scar and death of cardiomyocytes - a collective process known as myocardial remodeling. Diagnosis and treatment of this progressive pathological remodeling process are a top priority in modern healthcare.
The project aims to develop novel 3-dimensional (3D) human Magnetic HEART tissue based on unique magnetic nanoparticles (MNPs), and includes two world firsts: (1) a model for long-term live monitoring of ECM remodeling and (2) a new generation of scaffold-free myocardial regeneration techniques. Innovative MNPs will be designed and synthesized to target and specifically label human cardiomyocytes and human cardiac fibroblasts. By applying an external magnetic field, the magnetically labeled heart cells will be accumulated to produce 3D human cardiac tissue, comprising its own biologically-produced ECM, which will offer a practical alternative to native human heart tissue. For the first time, live biochemical changes in cardiac ECM during physiological and pathological remodeling will be monitored using state-of-the-art Raman spectroscopy, which can reveal fundamental insights and improve the basic understanding of this process.
This platform, which has not previously been reported, can be translated to treat the remodeled area in the heart by restoring structure and function to the damaged heart tissue, and marks a major breakthrough in magnetic targeting therapy for lesions localized deeper in the body. The outcome of this research has the potential to impact health and society and become a vital component in therapeutic approaches to cardiovascular diseases.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195665;658843;ChiralCatLnCoils;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;De novo design of Lanthanide coiled coils for asymmetric catalysis;1/09/2015;31/08/2017;;Herein, we propose to design de novo (from scratch), a new class of lanthanide coiled coils (LCC) for chiral catalysis in water. The attractive features of Lnn\ complexes (strong and hard Lewis acidity, high coordination numbers and rapid ligand-exchange kinetics), will for the first time be coupled with de novo designed coiled coils, which offer the advantages of the protein ligand in metalloenzymes, for applications in catalysis.The resulting novel LCCs will exploit the peptide fold, chirality and second sphere residues, in order to perform exquisite chiral catalysis in water. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology. The complementary expertise of Dr Anbu (bioinorganic catalysis) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full catalytic potential of LCCs, and will, in conjunction with two planned short secondments, provide Dr Anbu with new and cutting-edge research training.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195764;659299;FREE_TEEN_DESIRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Contributing to identify causes of gender violence among teenagers;17/08/2015;16/08/2016;;"The frequency of gender violence today is extremely high; 35% of women worldwide experienced either physical and/or sexual intimate partner violence or non-partner sexual violence (World Health Organization, 2013). In 2009, Miguel Carcao, adolescent, confesses to have raped and killed his ex-girlfriend, Marta del Castillo. After entering prison, a platform started in support of the self-confessed murderer, through which his admirers declared their desire to meet and to start a relationship with him. While many studies are being conducted to understand and ameliorate this situation, further research is needed to better identify the causes and consequences and to analyze in-depth methods that can advance research on this topic. The applicant has worked for the last fourteen years on the fact that some adolescents have been socialized into a type of relationships that link attraction and violence. FREE_Teen_Desire will draw from this background and learn from host expertise and methodological approaches in order to: 1) explore the extent to which dialogue situations (based on a language of desire) can question adolescent girls desires that link attractiveness to violent behaviours, 2) assess whether this dialogic questioning of girls desire, if any, is true beyond cultures, thus breaking down cultural and racist stereotypes associated to violence against women, and 3) develop the evidence-based approaches needed to increase effectiveness in the prevention of gender violence among adolescents. The research will have a mixed methods approach, involving a quasi-experimental study with 240 adolescent girls from four different countries and a qualitative analysis of some of their stories. The project will also innovate in dissemination and outreach activities in order to achieve political and social impact, in prevention campaigns and programmes against gender based violence.";97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195659;658825;jamclay;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Chemical Tools to Probe the Role of Bromodomains in the Parasite Trypanosoma cruzi;24/03/2016;23/03/2018;;"Lysine acetylation is a key protein post-translational modification (PTM) found throughout the cellular environment and across the range of species. This PTM is dynamic, with histone acetyl transferases (HATs) acetylating lysine, and histone deacetlyases (HDACs) reversing the modification. In addition, proteins modules bromodomains, have been identified that bind to acetylated lysine (KAc) and mediate protein-protein interactions. In humans, bromodomains exist as part of larger proteins, many of which are involved in transcriptional regulation. Bromodomains contain a KAc-binding pocket for which small molecule ligands have been identified. These ligands prevent the interaction of bromodomains with KAc and have been invaluable in dissecting the fundamental biology mediated by bromodomain-containing proteins (BCPs). We and others have developed potent ligands for the human bromodomain and extra C-terminal domain (BET) bromodomains. These compounds have antiproliferative effects in cancer cells lines and modulate inflammation and atherosclerosis. This work led to an explosion of interest in developing BET bromodomain inhibitors, resulting in 5 compounds in clinical trials. Despite rapid progress in understanding the role of human bromodomains, their function in other species is poorly understood. Given the fundamental role played by bromodomains in humans, we hypothesise that BCPs will play equally important roles in other organisms.

To understand the role of non-human bromodomains we will develop small molecule probes to study the function of BCPs in the parasite Trypanosoma cruzi. We have selected T. cruzi for two reasons: 1. Four BCPs (TcBDF1-4) have been discovered in T. cruzi; our collaborator Prof. Serra has cloned these proteins and we have the plasmids; 2. T. cruzi is the parasite that causes Chagas Disease and hence bromodomain ligands might ultimately represent a novel method of treatment for this disease.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195580;658266;AraMyco;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Uncovering the molecular dialogue between the arbuscular mycorrhizal fungi and the non-host plant.;1/05/2015;30/04/2017;;The arbuscular mycorrhizal (AM) symbiosis is one of the most ancient, abundant, and ecologically important mutualisms on Earth. Yet, despite its crucial role in land ecosystems, molecular mechanisms leading to its formation are just beginning to be unraveled. However, approximately 18% of all land plants, including important crop species, do not form a symbiosis with AM fungi (AMF) and can even be antagonized by them. These non-mycorrhizal plants include several major crops as well as many important weeds. Until now, molecular interactions between AMF and non-host plants have been poorly understood, possibly due to the absence of a suitable model system. Recently, it has been demonstrated that the non-host model plant Arabidopsis thaliana becomes heavily infected by AMF when exposed to mycorrhizal networks that are established by neighboring host plants, resulting in a strong reduction of growth of the non-host plant. However, arbuscules, the most characteristic structure in the AM symbiosis, have not been found in this interaction. These results point to a different interaction between A. thaliana and AMF compared to a functional symbiosis AMF host plant. Here we propose to utilize the well-established Arabidopsis model system to investigate the molecular mechanisms that explain the biological basis of AM fungal incompatibility through a multidisciplinary approach. We will test whether growth suppression previously observed in AMF-infected Arabidopsis is caused by nutrient limitation or by a costly activation of plant defenses. In addition we aim to identify gene regulatory networks that are activated in the three (fully sequenced) partners of the mycorrhizal network Medicago truncatula-Rhizophagus irregularis-Arabidopsis. This will allow us to study in detail key AM fungal genes and molecular processes that are responsible for symbiosis in host plants and for incompatibility in non-host plants, thereby providing novel tools to design new crop protection strategies;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 195729;659148;Legal Culture;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Legal Culture under Stalinism in Poland;1/09/2016;31/08/2018;;"The objective of the project is to describe the legal culture in Poland under communism on the basis of cultural texts, especially films and literature. No scholarly research of that kind has been done to date.
The experience of communism caused Polish citizens to distance themselves from laws and legally binding regulations and to use the strategy of playing the law. This means that members of the democratic opposition, while they understood that authorities treated communist law instrumentally, acted as if their basic rights were binding both for them, and for the authorities. The strategy in the long run was of considerable importance for the evolutionary exit from communism.
Conducting comparative research on the basis of cultural texts and currently available works of historians and sociologists will allow me to investigate (1) how the contents of these texts reflected and reacted to the oppression from the communist regime; (2) to what extent the rule-of-law environment of Central-Eastern Europe (CEE) is different from that of Western Europe, and (3) to what extent the Polish example might help formulate more general conclusions about the further implementation of EU legal norms in Poland and CEE, and might help us understand the legal culture of new democracies, e.g. countries participating in the Arab Spring.
The project will be realized at the SAXO Institute, University of Copenhagen, in close cooperation with main supervisor, Prof. Helle Porsdam.
The project will result in at least 3 articles in peer-reviewed academic journals, at least 4 presentations to an international audience, as well as a range of more popular works. It will provide (A) opportunities to acquire and transfer knowledge between Poland to Western Europe; (B) enhancement of my own creative and innovative potential in an international scientific environment.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195565;658183;TOTIPOTENCY2014;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dissecting the epigenetic control of totipotency.;1/01/2016;31/12/2017;;"One of the most critical epigenetic and chromatin remodelling processes in mammalian development occurs shortly after fertilization restoring totipotency. Due to limited cell numbers and lack of experimentally tractable systems, the mechanisms and regulation of this developmental stage are poorly understood. This proposal will provide important mechanistic insights into the epigenetic control of early embryonic gene expression, and its relevance to somatic reprogramming.

Murine embryonic stem cells (ESCs) contain a rare sub-population of early embryonic like (EEL) cells expressing genes normally restricted to the pre-implantation embryo, with enhanced extra-embryonic differentiation capability. Firstly, using novel single-cell technologies, I will characterize the EEL cells in detail, validating them as an in vitro model of pre-implantation development. On-going research in the host lab that I am involved in has identified an epigenetic enhancer that expands this EEL sub-population. Through bioinformatic analysis of pre-implantation transcriptome data, I have shortlisted 34 epigenetic and chromatin-associated proteins, including the previously identified factor, which will be systematically screened to identify new enhancers of totipotency. Validated EEL regulators, including two additional newly confirmed factors, will be analysed mechanistically determining their interaction partners, interdependencies, and mode of action. Finally, the contribution of the totipotency regulators towards the efficiency and fidelity of somatic reprogramming will be determined, potentially improving the use of this technology for personalised gene therapy and regenerative medicine.

This state-of-the-art proposal uses innovative and novel cutting-edge technologies and combines the expertise of the researcher and the host. It has the potential for significant impact across several fields from epigenetics and stem cell biology to reprogramming and regenerative medicine.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE BABRAHAM INSTITUTE;UK;;; 195681;658897;GLOID;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genetic and Lifestyle Origins of Inflammation in Depression;1/05/2015;31/10/2016;;"Depression produces substantial societal costs. Its cause is unknown and treatments are suboptimal. Inflammation may be involved in depression. People with depression have elevated levels of inflammatory mediators in the blood, although it is unclear whether the source is genetic, environmental, or some interaction. A likely environmental source is unhealthy lifestyle behaviours. To progress the field, studies must more directly test the causal status of the inflammatory hypothesis of depression; specifically, whether inflammation-related genetic polymorphisms or whole polygenic risk scores interact with unhealthy lifestyle in depression and its remission.

I will address these unanswered questions in a Marie Sk?odowska-Curie European Fellowship with Professor Penninxs research group at VU University Amsterdam; world-leaders in the investigation of psychobiological causes of depression. I will collaborate with experts in genetic epidemiology and the inflammatory hypothesis of depression and complete sophisticated statistical analysis of data from the longitudinal Netherlands Study of Depression and Anxiety (NESDA; PI Professor Penninx). It will result in at least four peer-reviewed research articles, related conference presentations, and opportunities to more broadly disseminate the findings.

Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in the psychobiological causes of depression, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing societal challenges to improve lifelong health and wellbeing of all. Providing evidence for the contribution of genetics, inflammation and unhealthy lifestyle to depression will provide opportunities for identifying people at risk of depression, treating depression, and developing individual and public health prevention strategies.";133199,11;133199,1;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VUMC;NL;STICHTING VU;NL; 195780;659378;SPIN2D;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spintronics with Non-Conventional 2D Materials;18/05/2015;17/05/2017;;"Since the discovery of graphene in 2004, a member of the two-dimensional (2D) materials family, the amazing properties of these materials at the single layer level have attracted an enormous attention. Thanks to the plethora of available compounds, an extremely wide richness of properties covering the full range of electrical and magnetic behaviors is expected. For spintronics, the combination of 2D layers in designed multilayer stacks can be envisaged as a way to obtain highly optimized modules that, combined altogether, will allow the realization of fully 2D advanced spintronic devices (2D spinFETs, 2D spinOLEDs, 2D MTJs for 2D memories, etc..) leading towards their ultimate miniaturization and engineering.
The multi-sectorial and interdisciplinary SPIN2D project aims at investigating the potential of 2D materials for spintronics and set a first step towards the future development of a new generation of spintronic multifunctional devices based on 2D building blocks. For this purpose, in an original chemistry and physics approach, SPIN2D will investigate and tailor the potential of two 2D materials families, Transition Metal Dichalcogenides (TMDCs) and Layered Double Hydroxides (LDHs), with the scope to: develop chemically engineered fabrication and deposition protocols; unveil and build an extensive library of relevant and combinable properties; and finally, integrate, combine and tailor 2D materials in multilayer spintronics devices.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE VALENCIA;ES;;; 195749;659263;Spinal cord fMRI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Functional magnetic resonance imaging of the cervical spinal cord at 7 Tesla;1/09/2015;31/08/2017;;Functional magnetic resonance imaging (fMRI) has become an indispensable tool in neuroscience to study human brain function non-invasively. However, translation of fMRI to investigate function of the second major component of the central nervous system, the spinal cord, has been severely hampered by technical difficulties. Two major challenges for spinal fMRI relate to the anatomy: (i) severe static image distortion caused by vertebrae and the lungs and (ii) dynamic signal instability introduced by breathing. I propose to address these problems by leveraging my expertise with cutting-edge technology for magnetic field compensation, available only to a few sites world-wide including my host institute in Oxford. These advances will enable me to take advantage of the signal-to-noise ratio improvement of ultra-high field (7 Tesla) MRI scanners, which has been clearly demonstrated in the brain but has remained elusive for the spine. The final stage of this project will deploy these methods on a collaborative project investigating the neurobiological mechanisms of pain in the spine. This project will enable me to build strategically on my dual training in engineering and medicine to develop an inter-disciplinary research profile at the interface of neuroscience and methodology.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195742;659205;Pathologies;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pathologies of temporality. Abnormal experiences of time in mental disorders;1/09/2016;31/08/2017;;The goal of the proposed research project is to analyze temporal disturbances in mental disorders and, as a result, to create a map of pathological experiences of time. The map will be phenomenological in nature, i.e. cutting across existing classifications of mental disorders and avoiding untimely biological explanations. The project is highly interdisciplinary it is situated at the intersection of phenomenology of temporality, philosophy of history and phenomenology of mental illness. It continues the tradition of philosophical-psychiatric reflections on time in mental disorders that started a century ago and that concerned temporal disturbances in conditions such as: addictions, amnesia, anxiety, dementia, depression, mania and schizophrenia. At the same time it enriches the existing empirical, clinical knowledge with non-medical interpretative schemes. The norm against which particular abnormalities will be assessed is going to be a value-based model of the relationship between past, present and future, and not value-free, physicalist notion of temporality. The major contribution that the project is going to make is bridging the gap between studies in philosophical textual analysis concerning temporality, which are theoretically sophisticated yet lack clinical references, and clinical papers, which will not serve its usual practical, medical function but pragmatically oriented philosophy. As a result, the study will constitute a major step toward answering two highly relevant philosophical-medical questions. First, can pathologies of temporality be interpreted as disorders in themselves, and not as epiphenomena built upon primary mental illnesses, and therefore provide ground for uniting otherwise separated categories of mental disorders? Second, how and to what extent can philosophical notions of time be applied not only to understanding of psychopathological phenomena but also to their treatment?;97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195765;659301;SOUNDCONE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Scattering and Amplification of fundamental photonic-hydrodynamic excitations in Kerr non-linear media;2/11/2015;1/11/2017;;"'Intense light beams propagating in nonlinear defocusing media behave identically to fluids. This raises the fascinating perspective of studying fluid dynamics using light. These 'photon fluids' and have been shown to exhibit remarkable properties such as superfluidity and condensation (similar to Bose-Einstein condensation). Here, we wish to use photon fluids for the creation of artificial flowing spacetime geometries otherwise thought to be the object of more complex and less (experimentally) accessible theories such as event horizons and black holes. The advantage of photon fluids over real fluids in this context is related to the great precision with which the fluid flow is determined by controlling the spatial phase profile of the laser beam. This will allow us for example to also include angular momentum in our black holes, something that has never been done before. In essence, we will study photon fluids with vorticity and look for novel effects including super-radiance amplification at the expense of the rotational motion of the black hole.

My studies will develop these ideas and account for the full experimental complexity, paving the way for experiments. These complexities include nonlocal effects within the photon fluid and possible deviations of the standard dispersion relation. These studies will also bridge the gap between Bose-Einstein condensate physics (BEC) and photon fluid physics and will focus on the presence of superfluidity within the photon fluid and novel methods for detecting related effects such as frictionless flow.

We will develop a quantised model for the photon fluid fluctuations and thus pave the way for the study of true quantum effects in these artificial fluids. Examples of these effects would be the amplification from quantum fluctuations.

These studies will on the one the hand push the boundaries of general relativity applied to condensed matter systems and on the other pave the way for room-temperature superfluid physics.'";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HERIOT-WATT UNIVERSITY;UK;;; 195863;659933;MARSS-5G;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Modeling and Analysis of Random Spatial Systems for 5G Networks;7/09/2015;6/09/2017;;"The United Nations International Telecommunications Union (ITU) has recently reported that the number of mobile users is expected to surpass the world population. In fact, it is expected that by 2020 mobile users will exceed an astonishing 9 Billion subscribers. With this unprecedented market penetration and growth, many communication engineering challenges are anticipated. In particular, next generation 5G wireless systems must be designed using sophisticated and innovative strategies and techniques. While 5G applications are expected to be diverse, the network architectures and devices need to ensure and deliver reliable, pervasive, and high-speed interconnection for various data-intensive applications (e.g., interactive multimedia streaming). These requirements must be accomplished while necessitating limited resources for a continuously expanding consumer demographics. Thus, deploying such complex networks is a formidable engineering feat that requires novel ways of modeling, evaluating, and designing extremely dense radio systems.

This project aims, through the study of spatial geometry of randomly deployed mobile units, to develop several analytical tools to model, design, and analyze complex 5G networks, and validate them through experimental datasets. Ultimately, our broad goal is to conceptualize an engineering research idea, and then transitioning it into innovative applications that can be replicated for real-world cellular networks operated by established service providers and mobile manufacturers.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CHALMERS TEKNISKA HOEGSKOLA AB;SE;;; 195752;659251;SSPinROOTS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Small Signalling Peptides for Stimulating Root Growth - a Novel Approach to Improve Nutrient Use Efficiency;1/05/2015;30/04/2017;;"Plants in the legume (Fabaceae) family are able to fix atmospheric N2 under N-limiting conditions, thereby diminishing the need for N-fertilization. N2-fixation has a high requirement for photosynthates and ATP, and is thus tightly controlled by both the N-availability in the soil and P-level in the plant. Increasing the P-uptake through formation of branched root system and abundant root hairs will increase the N2-fixing capacity and thereby improve the overall nutrient use efficiency (NUE). Small signalling peptides are a largely un-characterized group of regulatory molecules in plants that induce signal transduction pathways upon binding to their complementary receptor signalling modules. Even in the most studied model plant Arabidopsis thaliana only a few of the more than one thousand putative SSPs have been characterized. Very recent work has revealed unique roles of SSPs in alteration of the root system architecture in response to nutrient availability, including the formation of root hairs under P-limiting conditions. Hence, a deeper understanding of the functional roles of SSPs appears to be of key importance for improving NUE.
This project aims at advancing our knowledge of SSPs involved in the adaptation to nutrient limiting conditions in legumes beyond current state-of-the-art. This will be achieved using a novel bottom-up bioinformatic approach and unique mutant populations. The scientific objectives are (i) to identify the receptor signalling module and the down-stream target genes in the signal transduction pathway of a newly discovered P-responsive SSP essential for root hair formation, and (ii) to discover unknown N- and P-responsive SSPs in the roots and nodules of the legume model species Medicago truncatula with the aim of (iii) investigating the effect of SSPs on improving NUE. The proposed work will substantially advance our understanding of the functions in which SSPs are involved and will open up for new solutions aimed at improving NUE.";192162,6;192162,6;H2020-MSCA-IF-2014;MSCA-IF-GF;KOBENHAVNS UNIVERSITET;DK;;; 195848;659778;SEEING FROM CONTEXT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The neural basis of visual interaction between scenes and objects;1/06/2016;31/05/2018;;We easily categorize places and objects in a single glance, a computationally complex task presenting a central challenge for vision neuroscience. Considerable evidence points to a division of scene and object processing into two distinct neural pathways, relying on different types of visual cues. However, scenes and objects are also known to strongly interact in visual perception, as seen in contextual effects of background on object perception. At present, the neural mechanisms by which scenes and objects interact remain unknown, leaving a critical gap in our understanding of these two major visual paths. The main goal of this multi-method proposal is to uncover the neural mechanisms of scene-object interactions. I therefore propose three competing theoretical models. A parallel model predicts only stimulus-driven representations of scenes and objects in the visual cortex. In contrast, interactive models predict that representations of scenes and objects in the visual cortex are influenced by one-another. However, whereas a visual-interactive model suggests direct interaction, a feedback model suggests that the interaction is mediated by frontal regions. To test this, I propose a novel psychophysical paradigm of seeing objects from scene context and scenes from object context. Thereby, I will examine how scene and object processing are affected by one-another and identify the potential neural sources of these modulations using fMRI (objective 1). Thereafter, I will use MEG to decode the timeline of these neural processes (objective 2). Establishing a clear neurocognitive model for scene-object interaction would not only advance our understanding of the two central paths of the ventral visual stream, but also significantly contribute to the definition of vision as an interactive system rather than a set of specialized parallel modules. Shifting from localized visual modules to interactive visual processes will broaden my expertise as a cognitive neuroscientist.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI TRENTO;IT;;; 195643;658706;AfterTheIce;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;After the Ice: using a hybrid zone as a window into the genes underlying species formation;1/07/2015;30/06/2017;;The process of species formation is responsible for the global distribution of biodiversity, from the generation of species in habitats as extreme as the arctic or deep-sea thermal vents, to the generations of crop varieties that are locally adapted to different water regimes. Yet, we still understand very little about which genes drive the formation of new species, and what the nature is of selection acting on these genes. Evolutionary genetic studies have traditionally used either experimental hybrids from species that rarely meet in nature, or hybrid zones in uncontrolled conditions, often leading to conflicting conclusions. Here, we integrate both approaches in a single biological system: two grasshopper subspecies that maintain ecomorphologic differentiation despite ongoing hybridization since the end of the last glaciation. First, we will use experimental hybrids to test which genes are associated with reproductive dysfunction. We then use a hybrid zone as a natural laboratory to test if those phenotypes and genes contribute for stable boundaries between the two species in nature. Finally, we use samples distributed over a time series, to test whether those genetic boundaries are stable over evolutionary time. Rooted sound in my background of field- and lab-based methods, this project brings together state of the art genomic methods championed by the Center for GeoGenetics (Denmark), and the multidisciplinary knowledge on this species accumulated by the Universidad Autnoma de Madrid (Spain). By moving from lab to nature and through time, this integrative framework will not only provide unique insights on the field of speciation, but will provide a transferable framework that is applicable to emergent challenges of the modern society, such as identifying genes associated with human diseases and genes underlying adaptation of crop to stringent environments.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195734;659171;NovLeuReg;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification and characterization of novel essential regulators of acute myeloid leukemia;1/04/2016;31/03/2018;;Acute myeloid leukemia is a hematopoietic malignancy characterized by the abnormal proliferation of immature myeloid cells. The implementation of high-throughput sequencing revealed that somatic mutations in various epigenetic regulators represent a frequent pathogenic phenomenon in leukemogenesis. This raised optimism for the development of new therapies in leukemia due to the reversible nature of epigenetic marks and amenability of chromatin-modifying enzymes to pharmacological inhibition. However, realization of this potential requires further research into epigenetic mechanisms governing the maintenance of leukemic cells. The overall goal of the proposed work is to characterize novel important epigenetic regulators in leukemic cells and to assess their potential as drug targets. Firstly, I plan to identify and study epigenetic regulators essential for leukemic cells deficient in TET2, an enzyme that hydroxylates methylated cytosines in DNA. This will be achieved by performing state-of-the-art shRNA screens in mouse Tet2-null leukemia models and by exploring the functions of the uncovered candidates using a range of cell biology, biochemistry, and functional genomics approaches. The second aim is to investigate the molecular functions of SETD5, a newly-uncovered epigenetic regulator of leukemic cells. This will be achieved by identifying its target genes and interacting partners in leukemic cells and by exploring the effects of its depletion on normal and cancer cells. The accomplishment of both research aims will provide new insights into epigenetic regulation of leukemic cells and highlight novel drug targets for future therapy development. The project will be supervised by Prof Kristian Helin, a world-leading expert in the field of epigenetics and cancer. Through this work, I aim to broaden my scientific expertise by acquiring numerous technical and transferable skills and to establish myself as an independent researcher in the field of cancer epigenetics.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195843;659764;TRANSFORMERS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Creating transformation-stable microstructures through shared crystallographic motifs;1/05/2015;30/04/2017;;"While we continue to develop alternative and renewable power sources, the capture and sequestration of CO2 from flue gas in fossil fuel power plants and other industrial processes is one viable solution to decrease our CO2 emissions. CO2 can be removed from flue gas by chemical looping, where a material chemically reacts with CO2 and is treated at a later stage to release pure CO2 and regenerate the starting material. Limestone, CaCO3, is the oldest material to be used for this purpose. However, although limestone is abundant and cheap, the CO2 absorption capacity rapidly decays with use because of undesirable changes to the microstructure.
The proposed work will prepare and investigate novel ternary metal oxide ceramics designed to be mechanically stable after repeated thermal and CO2 cycling. In particular, the proposed work will determine whether similarities in the crystal structures of materials (the atomic scale) before and after a transition will lead to robust microstructures (the micro scale) that will retain functionality in this case, high porosity and CO2 sorption capacity. The complex crystal structures, rich phase space, and strong bonding networks available in ternary phases to be studied will lead to materials that are less prone to degradation. This evolution will be studied at the atomic level using in situ spectroscopic techniques, and the microstructure evolution will be studied using novel in situ X-ray tomography methods, which allow the 3D visualization of the microstructure in real time as the chemical transformations take place. These new approaches to material design will be immediately relevant to many other scientific fields where chemical transformations and mechanical stability are important, such as battery electrodes, solid oxide fuel cells, solid ion conductors, and catalyst supports, all of which suffer from performance loss over time due to microstructure changes.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195767;659311;StentFEM;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Advanced Finite Element Modeling of Arterial Stent Placement Procedures;1/10/2015;;;Arterial stenting has become a very important and successful intervention in vascular surgery. One of the most common scenarios includes so-called stent grafts, which are usually composed of a special fabric and supported by a metal stent mesh. Such stent grafts are used in endovascular repair (EVAR) to support weak spots and localized bulges (aneurysms) in an artery being at risk of rupture, most commonly for abdominal aortic aneurysms (AAA). The stent graft strengthens the weakened region of the arterial wall and excludes the AAA from blood flow and blood pressure. Over the last decade, an enormous thrust of research with regard to computational analysis of biomedical engineering problems in general, and with regard to hemodynamics, vascular mechanics and stent placement in particular has taken place. While significant progress has been made in all mentioned fields, computational analysis of stent placement using finite element methods (FEM) is still not predictive enough to give specific advice to vascular surgeons on how to optimally place the stent graft during EVAR. Instead, this decision is mostly based on the experience of the vascular surgeon. Risks of stent placement include a movement of the stent away from the desired location (migration), leaking of blood around stent grafts (endoleakage) and damage of the arterial wall caused by the stent itself. The main objective of the proposed research project is the development, implementation and validation of advanced FEM tools for stent placement simulation. The long-term vision is to be able to provide vascular surgeons with unprecedented predictive capabilities regarding the optimal choice of a patient-specific stent design (size, geometry, etc.) and stent positioning in order to safeguard against the risks mentioned above.;276274,8;276274,8;H2020-MSCA-IF-2014;MSCA-IF-GF;TECHNISCHE UNIVERSITAET MUENCHEN;DE;;; 195735;659174;MIPZ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Functional characterization of the cell division inhibitor MipZ;3/08/2015;2/08/2017;;Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;PHILIPPS UNIVERSITAET MARBURG;DE;;; 195650;658785;DISC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Distributed storage based on sparse-graph codes;1/05/2015;30/04/2017;;"The recent years have witnessed the explosion of services and applications such as email, cloud computing, social and media networks, and video sharing. The grand challenge is to store, process and transfer this massive amount of data. According to recent estimates, the data to be stored grows at a rate of 45% per year, a factor of 40 by 2024. Data centers typically employ a collection of cheap devices/nodes, which are connected forming a so-called distributed storage (DS) system, where a central server keeps track of where each file is stored and performs all network operations. Every day, knowingly or unknowingly people connect to various private and public DS systems.
It is nowadays accepted that current DS systems cannot face the unabated growing of digital data volume. Nextgeneration storage systems desperately need new technologies to improve their robustness to node failures, storage efficiency, complexity, and cost efficiency, in order to sustain the information revolution of modern societies.
This project addresses the challenges above using modern coding theory and optimization theory. Our focus is on the application of sparse-graph erasure correcting codes to large DS networks. The proposed project falls into the category of fundamental research, but it is driven by practical concerns, and we expect our findings to give new and relevant insights for the design of practical coding schemes for next-generation DS systems.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CHALMERS TEKNISKA HOEGSKOLA AB;SE;;; 195721;659106;GROUPIND;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Collective personalities: from individuals to groups, and back;1/10/2015;30/09/2017;;Many organisms, including humans, group together and perform collective actions such as birds forming coordinated flocks to evade predators, forage or roost. Some, as social insects, have evolved complex societies in which the unit of selection is not the individual, as in most vertebrates, but the colony. Yet, in both there is evidence of consistent behavioural variability among both individuals and groups. The study of collective behaviour - coordinated actions resulting in emergent properties at the group level - and the study of animal personality - between individual differences that are consistent over time and contexts - have progressed tremendously in the last two decades and are converging in their search for the link between individuality and collectivity, a fundamental and timely issue in biology. The GROUPIND project aims to investigate the relationship between individual personality and group personality by using ants and starlings as study organisms, both of which showing distinct collective behaviour and marked individual behavioural variability. The project will use a comparative approach to address the following objectives: (1) To characterize, also upon experimental manipulation, the composition of personalities in the group and understand how this relates to personality at the group level. Are group personalities an average of individual personalities within the group? Do they result from different distributions of individual personalities? Are there keystone individuals that exert a disproportionate influence on the group personality? (2) To understand how diversity of individual personalities contributes to decision making and to the ecological success at the group level, and how this would feed back at the individual level. By bridging two major fields of study, this project will shed new light on the ability of groups to function effectively, unravelling the consequences that personality differences can exert on social life and its evolution.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITE PARIS 13;FR;;; 195627;658574;FastTh;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fast Thermalization of the Quark-Gluon Plasma;1/09/2015;31/08/2017;;"Understanding the properties of extreme phases of nuclear matter created in relativistic heavy ion collisions is one of the major challenges in theoretical physics. Matter under such extreme conditions was present in the very early universe and is nowadays produced in relativistic heavy ion collisions. In this proposal we address two questions that are central to the understanding of the very early stages of such collisions from the perspective of both strongly and weakly coupled field theory: What is the time-scale of the thermalization and why does it happen so fast?
We will study these questions in the strongly coupled setup via the gauge/gravity duality by utilizing numerical relativity techniques to describe black hole formation in the gravity side. This allows to access real-time dependent non-equilibrium dynamical quantities and will improve the understanding of pre-equilibrium flow in heavy ion collisions. In order to understand thermalization at intermediate couplings we will carry out a comparison between strong and weak coupling approaches.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE BARCELONA;ES;;; 195667;658812;HAHPEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;House and home: physical and emotional comfort in the country house, England and Sweden c.1680-1820;1/10/2015;30/09/2017;;"Physical comfort and emotional well-being are common expectations and aspirations across 21st-century Europe. This fellowship explores an important episode in the historical development of these cultural and social norms. The 18th century was a time when the wealthy, at least, had access to a growing range of goods, commodities and technologies, and were becoming increasingly aware of their individual identity. The research focuses on the changing relationship between physical and emotional comfort in the context of the country house, and explores a number of key questions about how the desire for comfort related to gender and life course, and to material objects and the growing specialisation of domestic spaces; how it was perceived through different senses and how it was juxtaposed with feelings of discomfort; and how it was conceived and experienced in two contrasting countries within Europe places with very different societies, economies and climates.

The research draws on a wide range of archival sources and material objects, and engages with a variety of social and cultural theories and research methodologies: textual, statistical and artefactual. It is characterised by strong engagement with the heritage sector, through the provision of new interpretive frameworks and materials for selected historic houses, and with the public, who are invited to become actively involved as project associates and contribute to the analysis of objects and archives. Successfully completing of the project will involve knowledge transfer between the researcher and host institution, and will significantly develop the researchers career. It will produce a range of tangible outcomes, including academic publications, open access publications on dedicated web-pages, and public workshops and exhibitions, and will build sustainable networks of academics and professionals, thus enriching and integrating the ERA.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE MANCHESTER METROPOLITAN UNIVERSITY;UK;;; 195714;659070;Cyanolichens;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genetic diversity of cyanobacterial symbionts of lichens and of free-living populations of Nostoc in biological soil crust communities of threatened alvar grasslands;15/06/2015;14/06/2017;;Contemporary nature conservation policy in Europe has identified the protection of alvars and other semi-natural grasslands to be important for halting biodiversity loss. Loss of biodiversity implies not only species and communities but also loss of genetic diversity. To design effective conservation strategies for threatened biodiversity, the basic biology of the target organisms needs to be understood. Lichens are symbiotic entities consisting of at least two components, a fungus (mycobiont) and algae and/or cyanobacteria (photobionts), living in intimate symbiotic association. The genetic diversity of cyanobacteria will be studied in cyanobacterial lichens (cyanolichens) and in free-living cyanobacteria that form biological soil crusts (BSC) in North European alvars. The main DNA markers used will be tRNALeu (UAA) intron and 16S sequences for cyanobacteria and ITS sequences for lichen mycobionts. Cyanobiont specificity of lichen mycobionts and possible overlap in the cyanobiont spectra of different lichens will be determined. Also free-living Nostoc genotypes from the same habitats will be screened in order to establish their potential role in the symbiont pool. The diversity of lichen cyanobionts and free-living cyanobacteria in alvars, restored alvars and alvar-like substitution habitats will be compared to determine the effects of disturbance history on genotype diversity patterns. This study targets the very poorly known relationships between lichen-symbiotic cyanobacteria and their free-living relatives and will be the first of its kind in any grassland environment. The results will significantly improve our understanding of lichen biology and community ecology, and especially of the role of symbiont specificity in generating and maintaining lichen diversity. The results will have wide practical application in the design of conservation measures to protect the highly specialized BSC communities of the remaining semi-natural grassland in North Europe.;191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 195833;659680;CL-3DE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Choice and learning in a 3-dimensional environment: an investigation of brain and behaviour;1/05/2015;30/04/2017;;Recent research has shown that both humans and animals respond differently to rewarding objects when they are near compared to when they are far. I have developed a proposal to examine how proximity to rewarding objects impacts the brain, the choices we make and how we learn. This proposal has been explicitly designed to address the three key objectives of Horizon 2020. 1) Excellent Science: as a reintegrated researcher, I will transfer my knowledge of delivering immersive 3D stimuli in a laboratory setting to Jean-Claude Dreher's research group. Here, I will learn state-of-the-art techniques from the field of neuroeconomics to test the notion that a dual system network consisting of the striatum and hippocampus are critical to near and far choice outcomes. I will also test the notion that the same network is critical to how we learn about relationships in near and far space. 2) Competitive Industries: excellent immersive 3D will be essential to research outcomes. In the first of a two-part secondment, I will work with industry experts in visual effects to develop the highest quality stereographic stimuli for my experiments. Second, I will return to engage industry experts with my findings about how the brain is impacted by 3D screen imagery. 3) Better Society: I will engage with the public, especially younger people, from the outset to raise awareness about how the everyday choices we make can be influenced by environmental factors that we are often unaware of. I believe that this innovative research can have a significant impact on European society and industry and my career as a researcher.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195651;658833;ChemoBOOM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy;1/02/2016;31/01/2018;;The heterogeneity and capacity to evolve in response to treatment of the most aggressive forms of cancer make the selective inhibition of molecular targets an insufficient strategy to reach complete neoplastic remission. In this context, the unspecificity of classic chemotherapeutic agents becomes an advantage for treatment. Nonetheless, due to dose-limiting adverse effects, chemotherapeutic drugs become ineffective against some late-stage primary tumours, which are typically responsible for the death of the patient. To tackle those difficult to treat cancers, improved chemotherapeutic strategies far beyond the one-pill paradigm are mandatory. To reduce systemic side effects while increasing the levels of drug in the disease area, a number of novel methods originated from the Chemical Biology field (rather than from conventional Medicinal Chemistry approaches) have emerged during the last year to explore the site-specific activation of cytotoxic drugs. One of those novel concepts, pioneered by the Unciti-Brocetas group in Edinburgh, is based on the use of palladium to activate drug precursors by heterogeneous bioorthogonal organometallic (BOOM) catalysis. Using an O-propargylation strategy to mask functional groups essential for the cytotoxic mode of action of clinically-used drugs, I will investigate the development of novel bioorthogonal palladium-labile prodrugs and their reactivation in cancer cell culture by heterogeneous palladium catalysis. With the support of a MSCA-IF, I intent to explore the full scope of this exciting experimental strategy, including the first ever approach designed to release two cytotoxic drugs with synergistic pharmacological activity from a single prodrug molecule.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195706;659025;BAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A dynamical view of binding affinity;1/10/2015;30/09/2017;;Almost all critical functions in the cell rely on specific protein-protein interactions (PPIs). Understanding interactions is therefore a crucial step in the investigation of biological systems and in drug design. Despite all the research efforts that have been devoted to unravel principles of PPIs in the past decades, we still lack a thorough understanding of the energetics of proteins association, which is limiting our ability to consistently predict protein complexes, engineer high-affinity interactions and design new drugs. An improved understanding of protein binding affinity holds the key for resolving some of the most important problems in molecular biology, with wide implications in related fields. In this project I propose a novel approach to reliably predict the binding affinity by adding the so-far neglected dynamical dimension to the problem. Unlike traditional methods like empirical energy-based scoring, I will assess the conservation of interface contacts in protein complexes during dynamics trajectories. By correlating such properties to experimental binding affinities, a new predictor will be developed. Preliminary results on limited set of complexes already indicate that this approach has a great potential, outperforming any predictor proposed to date. Moreover, I will expand this novel approach and assess its applicability to other critical research fields related to biomolecular interactions, such as docking and proteins and interactions engineering. This project will allow me to reinforce and further expand my skills and expertise, create new collaborations and reinforce my position as researcher in Europe, which will enable me to reach full independency in the future.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 195701;659003;FUNFIT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fungal resistance to antifungals is promoted by cell heterogeneity;1/06/2015;31/05/2017;;"The number of people who die from fungal infections is estimated to be equivalent to or greater than the numbers that die from either tuberculosis or malaria. There are only 3 classes of antifungal drugs available to treat these invasive diseases and resistance against these drugs is increasing. In this study I will investigate how antifungal resistance is impacted by cell heterogeneity in the pathogenic fungus Aspergillus fumigatus. The main hypothesis that I will test is that fungal cell heterogeneity provides subpopulations of cells with greater fitness to resist antifungal treatment. I will determine: (1) which features of three distinct fungal cell types contribute to cell heterogeneity; (2) which cell types and subpopulations of these cells show highest resistance or survival against antifungals; and (3) the roles of septal plugging and cell ploidy in the mechanistic basis of fungal cell heterogeneity. Cutting edge technologies that will be used in this study will include: (1) flow cytometry and fluorescence activated cell sorting (FACS) to identify and select cell subpopulations to test their antifungal resistance, (2) automated, high throughput, high content live cell imaging to analyse the resistance of single cells to antifungals, (3) advanced live-cell imaging techniques including GFP photoactivation and fluorescence recovery after photobleaching (FRAP) to identify septal pore plugging; and (4) laser microdissection to further analyse septal pore plugging. With these advanced techniques I will study the mechanistic basis of fungal resistance mediated by cell heterogeneity. My results will ultimately show how fungal cell heterogeneity impacts fitness against antifungal drugs and they will be the starting point for designing novel antifungal therapies that reduce this fitness.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195628;658581;CODIR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cortical Dynamics of Decision Irrationality;1/04/2016;31/03/2018;;"Imagine that you choose a large house with a long commute over a small flat with a short train ride. Will the appearance of an inferior, thus irrelevant, alternativea small flat with a longer train ridemake you revise your initial choice? Contrary to what theories in economics prescribe people typically reverse their original choice in the presence of an inferior option. Contextual preference reversals (CPRs) of this form are hallmarks of human irrationality. Such deviations from rationality have been described in numerous behavioural studies over the past decades. But what are the mechanisms that produce CPRs? And why do CPRs differ across individuals? I aim to answer these big open questions. Specifically, I plan to elucidate the brain mechanisms that mediate CPRs, from the level of neurotransmitters, to large-scale brain networks, to behaviour. To this end, I will combine, for the first time, three novel approaches: a model-based approach I developed for quantifying irrational decision-making in a physiologically tractable fashion; delineating the neural interactions underlying decisions with magnetoenecephalography (MEG); and pharmacological manipulation of these interactions. I will then use the MEG data to guide the development of a biophysically constrained mechanistic model of irrational decision-making. This model will be used to generate novel predictions about CPRs in the healthy brain as well as in several neurophysiological disorders. In sum, my research will tackle long-standing problems from the behavioural sciences with techniques from the life sciences, thus providing a deeper understanding of the limits of human behaviour. I will be thoroughly trained in advanced neurophysiological techniques in preparation for a career in the nascent field of computational psychiatry. Finally, this project will bring together leading scientists from the behavioural, neural, and physical sciences, establishing a new multi-disciplinary EU research network.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF;DE;UNIVERSITEIT VAN AMSTERDAM;NL; 195613;658483;HARPOCRATES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Smart phononic crystals for aircraft noise reduction;1/12/2015;30/11/2017;;"Nowadays air transport is a vital means of integration, cohesion and economic development amongst European members. However, due to the incessant growth of the global air traffic, aircraft noise pollution has gradually become a major public issue. Thus, European Union is strongly addressing its aviation industry towards a more competitive and sustainable system. HARPOCRATES perfectly shares this current international trend and aims to develop a new-generation sound insulation system to attenuate aircraft noise emissions, in accordance to the EU noise transport policy which over the coming years will require more and more quiet operating vehicles. HARPOCRATES proposes to achieve such a technological breakthrough manipulating sound waves via phononic crystals (PCs), i.e. artificial materials ideally suited for realizing efficient filters or insulators. In fact, the project intends to exploit PCs to proficiently control elastic waves via the so-called pass bands (PBs) and band gaps (BGs), which permit and inhibit, respectively, the waves to propagate within precise frequency ranges. Specifically, proposal objectives provide the design, optimization and experimental validation of the engineered innovative device, promoting theoretical and experimental evidences capable to move aircraft noise reduction expertise towards new horizons.
The fully accomplishment of the project objectives will speed up a technological breakthrough development in the framework of aircraft noise emissions, enhancing and maximizing its contribution to the European knowledge-based economy and society. In addition, HARPOCRATES allows the applicant to fully develop his potential thanks to an ad-hoc specialized and advanced training provided to the candidate in the course of the project. Proposal permits as well to strengthen contact networks of both the researcher and the beneficiary, offering unique opportunities to acquire and transfer new knowledge in an outstanding European working context.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195636;658651;GEODEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Geography of Demography: modelling plant population responses to global habitat patterns;1/06/2015;31/05/2017;;Mankind is profoundly altering the environments in which plant and animal populations live. An era of such massive habitat rearrangements requires ecologists to take new approaches to increase our understanding of species distribution and likelihood of persistence worldwide. Improved ecological models of range-wide persistence and response to the simultaneous threats of climate change, habitat destruction and landscape reconfiguration are required to inform management of biodiversity at large scales. GEODEM brings together global datasets of plant distribution and demography to gain insight into how the geographic configuration of habitats affects growth, survival and reproduction of more than 500 plant species worldwide. The project has two main objectives: 1. Geographic Range Pattern Analysis: Using species distribution models and global spatial statistics tools to quantify and compare spatial patterns of suitable environmental conditions across species biogeographic ranges. 2. Landscape Demography: Testing how the spatial arrangement of suitable habitat within the geographic space can inform population responses to environmental gradients. The fellow will be supervised by and collaborate with world leaders in spatial ecology in Ireland and other European countries to accomplish her goals. The prestigious Marie Sk?odowska-Curie fellowship will enable her to develop expertise in currently disparate areas of species distribution modelling and demography and place her in a unique position to make significant contributions to the urgent problem of population persistence at large scales during this era of global change. It will enable the fellow to build an independent research program in Europe after gaining research experience in top universities in Canada and Australia.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;IE;;; 195699;658999;Modeling ERPs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Combining electrophysiology and cognitive computational modeling in research on meaning in language;1/08/2015;31/07/2017;;"Language and meaning processing have been investigated with event-related brain potentials (ERPs), providing direct time-resolved measures of electrical brain activity, and with connectionist network models, providing mechanistic implementations of the assumed processes. However, there has been very little contact between these fields, even though a combination of both methods could be highly beneficial. Based on initial evidence from the applicant, the present project therefore aims to integrate ERPs and computational models in research on language and meaning.
Specifically, the N400 ERP component is widely used in research on language and meaning. As the computational mechanisms underlying this component are still unclear, we recently related the N400 to a model of word meaning and observed a close correspondence between N400 amplitudes and semantic network error. As network error is often conceptualized as implicit prediction error, we took these results to indicate that N400 amplitudes may reflect implicit prediction error in the semantic system.
However, because the most typical N400 effects are observed during sentence processing, I propose to extend connectionist N400 simulations to sentence processing (Objective 1). Furthermore, the development of syntactic and semantic knowledge in the model should be related to the development of syntactic and semantic ERP components, both in developmental time and when processing words in sentences over time (Objective 2). Next, we aim to test behavioral predictions derived from this model-based account of N400 amplitudes, namely that larger N400 amplitudes should enhance implicit memory formation (Objective 3). Finally, the model-based account of N400 amplitudes as reflecting implicit prediction error should be tested in a conceptually similar theoretical framework, namely the Bayesian brain hypothesis. Thus, we will model N400 amplitudes as Bayesian surprise in the semantic system (Objective 4).";159795,6;159795,6;H2020-MSCA-IF-2014;MSCA-IF-GF;FREIE UNIVERSITAET BERLIN;DE;;; 195751;659221;ReconsolidationDynamics;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;A Cross-Species Investigation of Memory Replay During Reconsolidation;1/06/2015;31/05/2018;;A primary treatment for anxiety disorders is exposure therapy, which is based on the principles of extinction, but has the drawback that fear can return. This risk of relapse highlights a need for treatments that persist. Research on reconsolidation has shown that upon reactivation old fear memories can be updated, preventing the return of fear. However, studies targeting reconsolidation to reduce fear have reported mixed results because its boundary conditions are poorly understood. To live up to its clinical potential it is necessary to understand how to most effectively utilize paradigms targeting reconsolidation. The proposed research attempts to address this issue by providing a neural measure of the reconsolidation process itself. This will be achieved by determining whether dynamic patterns of neural network activity that occur during initial learning re-occur during offline rest periods, and test whether this replay of memory is linked to reconsolidation. The first objective of this grant application is to identify and quantify a neural marker of reconsolidation that predicts the absence of fear recovery. During the outgoing phase these questions will be addressed employing an innovative cross-species (humans, rats) approach using similar behavioural tasks, complementary recording techniques (functional magnetic resonance imaging, multi-unit recordings) and state-of-the-art analyses methods. Acquired knowledge and experience will be applied during the return phase where the second objective is to use this neural marker to determine how context serves as one critical boundary condition to inducing reconsolidation. Findings will significantly advance fundamental understanding of reconsolidation and have important implication for applied and preclinical psychiatric research.;242929,8;242929,8;H2020-MSCA-IF-2014;MSCA-IF-GF;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 195621;658554;N-SHEAD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanoarrays: Self-assembled Hotspots for Enhanced Analyte Detection;8/04/2015;7/04/2017;;"I aim to transform the way disease is currently detected through innovations in the design of nanoparticle-based biosensors that can be used to detect a number of diseases with global implications. The three most significant challenges facing biosensing are inaccuracy, insensitivity, and low-throughput detection. One technique that is capable of facing these challenges is Surface Enhanced Raman Scattering (SERS) which has demonstrated potential for extreme sensitivity (single molecule detection) and rapid, multiple-analyte detection within complex mixtures. Early stage diagnosis of disease requires the detection of trace amounts of analyte in multi-component biological samples (blood, urine, saliva). It is therefore particularly important for sensors to reach the single-molecule detection limit. Further, the ability to analyse biological samples without separation or other treatment steps is a crucial advantage of SERS.
My approach involves the electrotuneable self-assembly of plasmonic nanoparticles at a liquid-liquid interface for SERS detection, overcoming the severe limitations of current sensors (sensitivity, specificity and speed). I will electrochemically control the positioning of the nanoparticles in a precise manner to maximise the Raman signal. Additionally I will utilise shaped nanoparticles, such as stars and ellipsoids, exploiting the enormous Raman enhancements observed at sharp metallic tips to push the sensitivity towards single-molecule detection limits. The ultrasensitive sensing capabilities will be extended to colorectal cancer diagnosis the third most prevalent cancer in the world which effects 1.4 million people per year. Due to the versatility of this system it can be adapted to any disease or virus where the related biomarker is known. This approach will allow me to build a new generation of sensors that will transform single-molecule SERS detection.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195737;659183;RECOLOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Regulation and consequences of LRRK2 phosphorylation,a path to Parkinsons disease therapy and diagnostics;1/06/2015;31/05/2017;;"Parkinsons disease (PD) is the most common neurodegenerative movement disorder, currently incurable. Studies in the PD field show that leucine-rich repeat kinase 2 (LRRK2) is both a major player in PD pathogenesis and a promising PD therapeutic target. LRRK2 functions in health and disease are not defined; however the applicant and others have shown that LRRK2 phosphorylation is the key to understanding LRRK2 biology. This projects goal is therefore to understand the role of LRRK2 phosphorylation in PD by pursuing 3 specific aims: 1) elucidate the regulation of LRRK2 phosphorylation by phosphatases, 2) determine LRRK2 phosphorylation downstream phenotypes in cellular models through transcriptome profiling, protein translation profiling and protein tau related phenotypes, and 3) verify these findings from experimental models in PD biosamples. The project builds on the applicants extensive expertise in the field of LRRK2 biology (24 papers in 8 years) required for aim 1 and will leverage expertise on PD biosample analysis of the host institution (training for aims 2 and 3). The research program will be performed at the JPA research center (a mixed Inserm-Lille 2 University-Lille University Hospital center for excellence research, Lille, France), with a network of strategically chosen collaborating research groups locally and internationally, coordinated by the applicant. The study of LRRK2 phosphorylation in experimental models and translation of experimental results to clinical samples will reveal the most relevant molecular mechanisms of LRRK2 in PD which can be exploited in follow up work as diagnostic biomarkers and targeted for disease-modifying therapy. Given the importance of PD and neurodegeneration in Europe, this project is fertile ground for a high visibility fellowship and will reposition the applicant in the international neurodegenerative diseases research community by adding a clinical translation dimension to his signalling neurobiologist profile.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE LILLE II - DROIT ET SANTE;FR;;; 195719;659102;GroupsComputability;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Algorithms in algebra and topology;1/10/2015;30/09/2017;;"Group theory is the study of symmetry in mathematical objects, such as rotations of geometric shapes.
Groups help us understand the underlying structure of mathematical objects by revealing their symmetries.
To understand groups we need an efficient way to describe them. Some groups admit a finite presentation; a finite set of building blocks, along with a finite collection of rules on when we can substitute one set of blocks for another. These descriptions are convenient. However, results in algebra and logic show that such descriptions are not always suitable to work with, as certain problems (e.g., the word problem, of deciding if two distinct collections of blocks represent the same group element) are incomputable; no computer can be built to always answer this. We can embed incomputable problems from groups into geometry, to show that the homeomorphism problem, of recognising if two geometric shapes are equivalent under smooth deformation, is incomputable in all dimensions above three. Thus we can't computationally classify geometric shapes in higher dimensions; we can't identify the unique distinguishing features of each shape. The study of generic computability (problems which can be computed most of the time) is a useful area in mathematics. Conversely, showing a problem can't be computed most of the time gives rise to applications in cryptography: generically incomputable problems are an excellent tool in the theory behind cryptosystems. This proposal will deal with incomputable and generically incomputable problems.
We will investigate certain problems in group theory to determine if they are computable, or generically computable, or neither. We will apply these results to particular classess of higher-dimensional geometric objects, identifying whether certain problems relating to them are computable or not. The project will be carried out at the University of Cambridge, under the supervision of Dr. Henry Wilton.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195722;659114;MULTISSOUND;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multisensory-Based Spatial Sound;1/11/2015;31/10/2017;;"The worlds of multisensory research and multimedia technologies have originated and, for the most part, still remain largely independent. The first exists mostly within the field of experimental psychology, or psychophysics, while the second one is mostly studied and developed by engineers. This project aims at implementing this perfect multidisciplinary marriage in the field of acoustics. A series of psychophysical experiments will be carried out at Aalto School of Engineering, in the Spatial Sound Group, aiming at obtaining detailed guidelines on how to reproduce sound for the best audiovisual experience. The results will be further applied to a new sound spatialization algorithm designed specifically to enhance human audiovisual experience, while reducing computational complexity where it is not needed. The ultimate goal is to reach every consumer, namely in television, cinema, gaming, computer streaming and teleconferencing applications. Direct actions to reach the general community, as well as the industry, will ensure maximum practical impact.
I am a young researcher, in psychoacoustics with strong background in multisensory interactions, as demonstrated by numerous publications and projects. My supervisor is a highly regarded scientist and developer of spatial sound algorithms that are implemented worldwide. I am from Portugal, the host is Finnish; I am a psychologist, and the research group is composed of engineers. This extremely innovative project, complementary at so many levels, will create a perfect combination for my personal scientific development and open great career opportunities, while bringing immediate institutional benefits. The topic is framed within one of the most profitable business areas in the world, Europe being no exception. This project will bring a very significant change to that field.";191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AALTO-KORKEAKOULUSAATIO;FI;;; 195704;659021;PHELLINI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Plasmonic Heaters Linked to Lanthanide-Based Nanothermometers for Photodynamic Therapy in the Near-Infrared;1/11/2015;31/10/2017;;"This project addresses the quest of new materials and approaches that nanotechnology requires to solve the current limitations of medicine. The potential to externally activate and control cellular processes inside the body by using light, or even to carry out treatments through drug delivery, photothermal and photodynamic therapies becomes a reality thanks to the use of especially tailored biocompatible nanoplatforms. However, the options are limited in terms of penetration depth, since most of the developed nanoplatforms work under visible light, which can only penetrate a few millimetres inside the body. Instead, the use of near-infrared wavelength allows light to travel distances in the centimetre range.
Temperature is a key parameter for the metabolism of cells and to control chemical reactions. Therefore, we propose a hybrid nanoplatform that, working within the biological transparency windows in the near-infrared, optically measures and controls temperature with the accuracy that is required for biomedical applications. The novelty of the approach is based on coupling two different types of nanoparticles with complementary functionalities: lanthanide-doped materials as remote optical sensor to measure temperature, and metal nanoparticles with plasmon resonances in the near-infrared to exploit their excellent heating properties. This approach involves the development of new materials with outstanding physical properties for thermometry in the infrared (hardly existing now), as well as tailoring the heating properties of plasmonic nanoparticles with different morphologies (rods, stars or cages) and finally, the creation of a heater/thermometer hybrid structure and the study of its performance for in vitro photothermal therapies.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE;ES;;; 195727;659135;HLQPT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Holographic lattices and quantum phase transitions;1/06/2015;31/05/2017;;The anti de-Sitter/conformal field theory (AdS/CFT) correspondence has provided a new inter-disciplinary way to the study of strongly coupled systems and has an impact in various areas in physics, including quantum field theory, hydrodynamics, QCD, condensed matter physics, quantum information, etc. In this proposal we focus on the application of AdS/CFT to condensed matter theory (AdS/CMT), which is an inter-disciplinary subject combining gravity, string theory and condensed matter physics. As a fast developing field AdS/CMT has had a lot of achievements and also attracted the interest of many condensed matter physicists. To apply AdS/CMT to the real world condensed matter systems, we need to encode translational symmetry breaking in holography, which makes it important to construct and understand holographic lattice systems. A lot of success has been obtained in this direction and people even found very similar behaviour of optical conductivity in holographic models to that of cuprates in experiments. However, the current study of holographic lattice systems is not adequate when we want to investigate deeper into the cuprate phase diagrams and describe the more complicated and realistic lattice structures with broken lattice symmetry. In this proposal we aim to find the holographic descriptions of incommensurate and commensurate phases and study the transport properties and phase diagrams, especially quantum phase transitions to gain more insight into the understanding of cuprates and the deep reason of why some holographic models are able to produce the same behaviour of optical conductivity as in strange metals.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195598;658368;NanoSyNNets;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanowires to study single synapses in patterned neuronal networks.;1/03/2015;28/02/2017;;"In neuronal networks of the brain, synapses are the connection points between neurons. The dynamics (or plasticity) of these synapses allow us to think, learn and memorize. A deeper understanding of these phenomena requires investigations of single synapses. Synapses have been intensively studied in vivo but in such studies the physiological complexity limits the investigations at the single synapses level.
Despite tremendous technical and conceptual advances of in vivo studies, we miss (1) a better understanding of the mechanics of synapses formation; (2) observing directly the chemical activity at single synapses; (3) investigating the role of neuronal network topology in synaptic plasticity. These classical limitations can now be overcome by alternative in vitro approaches, using recent technological advances in microfluidics and nano-technologies.
The aim of NANOSYNNETS is to use vertical arrays of NANOwires (aNWs) to study in vitro the formation and plasticity of single SYnapses in Neuronal NETworkS with controlled topologies.
With my expertise in growing controlled neuronal networks in microfluidic chips, I decided to join the one of the leading group in bio-nanotechnologies, lead by Karen Martinez (KM) and based at the NanoScience Center (NSC) of the University of Copenhagen (UCPH), to exploit novel technologies for the investigation of in vitro single synapse formation, activity and plasticity. This novel approach will give a complementary and cutting-edge point of view to classical in vivo studies of synapses and will thereby provide unmatched insights into neurobiology and will shed new lights on unanswered questions in learning mechanisms or neuronal communication.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195689;658933;HGSOC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A novel approach into modeling origin and development of ovarian cancer;1/08/2015;31/07/2017;;"High grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian tumors, and is the 5th leading cause of cancer related deaths among women in the western world. Recent studies have pointed at the fimbriae of the fallopian tube (FT) as one of HGSOCs main origins. The existence of FT stem cells (SCs) has been suggested, however, their isolation and characterization have been so far elusive. Given the potential of SCs to accumulate mutations, these cells may represent one of the cellular origins of HGSOC.
This project is aimed at identifying SCs of the FT, evaluating their tumorigenic capacity and establishing a novel in-vitro human model for HGSOC development.
Preliminary screening experiments of well-established SC markers have identified Lgr6 and Troy expression in the mouse oviduct. These putative SC populations will be further characterized and their capacity to maintain tissue homeostasis will be analyzed by lineage tracing experiments. Next, mouse and human organoid culture systems of FT and HGSOC will be generated. Mutating normal FT organoids in specific genes, using the CRISPR/Cas9 system, will enable following putative SCs tumorigenic capacity upon their injection to mice. Furthermore, it will generate an innovative in-vitro model of ovarian cancer development. Finally, HGSOC organoids will be used to model and follow chemotherapy resistance acquisition.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;NL;;; 195674;658863;SEDiLINK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sediment linkage between land, river and sea: evaluating impacts of historic mining on sediment quality in the coastal zone;1/07/2015;30/06/2017;;"Monitoring datasets available to evaluate past mining impacts on catchment and coastal environmental quality are severely limited in temporal extent presenting a major hindrance to effective decision making for management of legacy pollution to achieve the goals of the EU Water Framework Directive and Mining Waste Directive. The Sediment linkage between land, river and sea: evaluating impacts of historic mining on sediment quality in the coastal zone (SEDiLINK) research project will develop an innovative sedimentological approach to overcome these important challenges and close this substantial knowledge gap. The SEDiLINK approach will bring together established techniques (e.g. Pb-210 geochronology) with new approaches in evaluating riverine ecosystems (e.g. Pb isotope fingerprint) and deliver an integrated toolkit for evaluation of mine waste impacts. The extensive metal mining history of Tamar River Basin and coastal zone, southwest UK, offers an ideal test-bed in which to develop the novel and powerful SEDiLINK approach for wider application in other EU contaminated fluvial and coastal ecosystems requiring longer term remediation legacy pollution.
Through developing this tool, the candidate will gain new scientific and technical skills in cutting edge isotopic fingerprinting techniques working with multidisciplinary and multinational groups in UK and Spain, developing and complementing her previous knowledge in radiotracer applications. This period of advanced training and mobility will underpin maturation and independence as a leading EU researcher.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF PLYMOUTH;UK;;; 195686;658917;MANGANOXI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The development of manganese-based alkene epoxidation, cis-dihydroxylation and alkane C-H oxidation catalysts;1/09/2015;31/08/2017;;The catalytic oxidation of alkenes to give epoxides and syn-diols, as well as the hydroxylation of C-H bonds in alkanes using environmentally benign reagents and conditions remains an area of significant challenge in contemporary synthetic chemistry and highly effective catalytic systems remains elusive. In the MANGANOXI project a novel and ecologically friendly approach towards the development and application of manganese-based catalytic systems is proposed. The project first focuses on the use of a known manganese complex (MnTMTACN) together with Lewis Acids and hydrogen peroxide as a stoichiometric oxidant, generated using a co-catalyst from dioxygen, in the epoxidation of alkenes. The project will then develop analogues of other ligand systems to integrate click generated 1,2,3-triazoles as pyridine surrogates, which should result in modular ligand systems which can be readily tuned. In addition, in order to obtain easier isolation of products and enable catalyst recycling, the most effective ligand systems will be anchored onto selected support using click chemistry. The use of the copper-catalysed [3\2] click Huisgen cycloaddition of an alkyne and azide is indispensable, as it facilitates both the anchoring of the ligand on the support and the incorporation of the pyridine surrogate into the ligand architecture. The catalytic oxidation reactions using the immobilized metal-ligand complex will then be conducted in a flow reactor, which will result in enormous potential of application in industry, by virtue of estimated high reproducibility and unrestrained scale-up of reactions. The MANGANOXI project will not only contribute to European excellence and competiveness, but also reflects the principles of Green Chemistry and Technology for Sustainable Development.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195707;659029;KREDs in GSBs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Directed evolution of ketoreductases in gel-shell beads;1/06/2015;31/05/2017;;Optically pure secondary alcohols are required in the manufacture of many pharmaceutical products. Ketoreductases (KREDs) capable of reduction of ketones to the corresponding secondary alcohol have been improved through classical directed evolution campaigns but a limiting factor has always been the challenge of matching selection conditions to the final scaled-up reaction. Here we propose a solution to that problem. The Host group previously described the formation of gel-shell beads, agarose beads surrounded by a size-selective shell (Nature Chemistry 2014, 6:791). The beads allow screening of individual members of an enzyme library using flow cytometry. As small molecules can be readily exchanged, while enzymes are retained, the process not only affords precise control over selection conditions but also makes it ideal for continuous flow processes. To support this endeavour, sensitive assays for the high throughput detection of ketoreductase activity and enantioselectivity will be developed. Directed evolution will then be performed with selection for the efficient use of macromolecular derivatives of the NAD(P)H cofactor and improved tolerance to high substrate /solvent concentrations. Throughout the project, intensive contact will be maintained with Industrial Partner GlaxoSmithKline, leading up to flow bed reactor trials during a secondment. This project will provide the Beneficiary with an excellent training in biocatalysis, broadening his skill set and opening up new career opportunities in Europes growing Green Chemistry Sector. The Host laboratory is at the forefront of directed evolution of enzymes. Through the secondment at GSK, the Beneficiary will be able to transfer this technology to industry. Excellent training courses offered by the University of Cambridge will further aid his professional development. This project seeks to help Europe meet Part 12 of Horizon 2020, which is to be communicated through a well-planned series of Public Engagements.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195583;658285;FOREMOTIONS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Formal Frameworks for Modal Notions Conceived as Predicates;1/01/2016;31/12/2017;;Philosophy strives for a better understanding of modal notions such as necessity, possibility, truth, knowledge. Modal logic, however, the formal tool privileged by philosophers to shape their theories about intensional notions, displays severe drawbacks: its use determines an incoherent treatment of different kinds of modalities and it is expressively weak as important general claims are not fully formalizable in it. In the project I develop an alternative approach to modal notions. Instead of treating them as operators applying to formulas, I will consider them as predicates applying to terms naming formulas. The overarching aim of the proposal is to provide philosophy with an expressive and coherent framework that could represent a valid alternative to modal logic. More precisely, I will develop three research objectives corresponding to three fundamental research gaps traceable in the current literature on modal predicates: the formulation of a natural account of the bearers of modal notions, a consistent and mathematically powerful treatment of the interaction of modal predicates, a predicate approach to de re modal ascriptions that will open the way for a new approach to modal metaphysics in the predicate setting. The project will develop a unified effort to bridge mathematical logic, philosophy of mathematics and metaphysics. It will result in the establishment of leading research profile setting the agenda for a network of researchers in the flourishing area of mathematical philosophy.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195691;658967;TIME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Time of damage in classic galactosemia: is prenatal toxicity a determinant factor?;1/10/2015;30/09/2017;;"The TIME project aims to ascertain the time at which the toxicity observed in classic galactosemia begins, particularly if it begins prenatally. Recent advances in the molecular bases of classic galactosemia have taken research a step further towards therapy development. Therefore, it is of utmost importance to elucidate when the damage accurately begins, in order to define the time at which therapy should be initiated so that it can effectively prevent the development of long-term complications.
The Galactosemia Research Group (GRG) in Maastricht has recently developed a zebrafish model of classic galactosemia, which is particularly indicated for studying developmental processes. I will use transient embryological- and whole life-knockout galt-zebrafish to analyze damage in target-organs at different stages of pre- and post-natal development and compare them to the wild-type fish, which will allow determining the exact time of damage onset in classic galactosemia.
The GRG is a world-renowned multidisciplinary group that will strongly enhance my professional and personal qualifications as a researcher. In turn, I will contribute with my expertise in molecular bases of rare metabolic disorders.
This project constitutes a major milestone for this disorder, as it will allow the development of an effective treatment, which in turn will decrease galactosemic patients' requirement for medical assistance and by making them fit to work and to fully engage in the society.
Prof. Patrick Cunningham (Trinity College, Dublin) once said: To be a researcher is not just to be in the laboratory, you work for the world, you work for the society. This sentence illustrates what I have always felt to be my purpose as a researcher. Ever since I initiated my scientific career that I am fully committed in taking research in rare disorders towards the improvement of patients health and lives, and this fellowship constitutes an important step towards that commitment.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT MAASTRICHT;NL;;; 195712;659065;INNOVCITIES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Institutional Innovation for Adapting to Climate Change in Water Governance within Cities;19/10/2015;18/10/2017;;"This research will address the problem of the currently insufficient level of institutional innovation in water governance systems in the context of climate change. Climate change creates urgent need for adaptive water governance that can anticipate and respond to increasing pressures on water systems within human society. Cities are a key locus of attention. Institutional innovation is needed (e.g. policy change, new organisational setups, new inter-organisational arrangements). However, knowledge of the types of institutional innovation required and the mechanisms (e.g. political, institutional) by which it emerges is lacking. Therefore I will address the question: What types of institutional innovation are required for adapting to climate change in water governance within cities, and how can we better understand why and how they emerge? This will involve: (1) global assessment of institutional innovation in water governance in 30 cities across 6 continents to identify broad patterns and best practices across the world; (2) comparative case study analysis of 3 innovative cities across 3 continents in contrasting global contexts to attain deeper understanding of dynamics underpinning innovation; and (3) dissemination of results and policy recommendations to enable innovation in cities in Europe and globally. By addressing this urgent research and policy problem, the MCSA fellowship will enable me to develop new expertise, academic and policy networks, and research profile that will position me as a leading emerging scholar in the field of water governance and climate change adaptation. The research will contribute to the knowledge based economy of Europe by providing critical new academic and policy insights to safeguard against water-related vulnerabilities in cities under climate change, and contribute to addressing two of the European Commissions Grand Challenges (i.e. climate action; and innovative and reflective societies).";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VU;NL;;; 195671;658851;MaSCheNav;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mass Spectrometry-Based Chemoproteomic Profiling of Nav1.7, a Voltage-Gated Sodium Channel;1/11/2015;31/10/2017;;Chronic pain represents a major unmet medical need which has been linked to changes in voltage-gated sodium channels (VGSCs). These channels are transmembrane protein-complexes with a key-role in signal transmission in excitable cells, such as neurons, and allow the flux of Na\ ions through the cellular membrane in response to specific stimuli, thus controlling the generation and propagation of action potentials. Nine VGSC subtypes are known to be expressed in different cell types, and among them subtype Nav1.7 is of extreme interest since it is involved in nociceptive processing (pain-sensing) in the peripheral nervous system. Remarkably, patients suffering from congenital indifference to pain syndrome, which derives from loss-of-function mutations of the gene encoding for Nav1.7, have a dramatically reduced ability to perceive painful stimuli, but are otherwise perfectly healthy. Therefore, Nav1.7 has been recognized as an exciting target for pharmacological treatments of pain. However, detailed structural and functional information is lacking, and its attainment represents a fundamental step in the challenging task of finding Nav subtype-selective modulators. Thus, the main focus of my project is to study ligand-binding events with known modulators, thereby paving the way to the design of safe and selective inhibitors. I will develop, by solid phase peptide synthesis, a chemical probe specifically designed to isolate Nav1.7, using a tandem photoaffinity labeling-bioorthogonal conjugation approach. This probe will be applied in model cell lines expressing the channel, in order to study their binding interaction through mass spectrometry-based chemoproteomics. Once these chemical tools are established and validated in the model system, I will translate them to patient-derived cells, in order to study disease-relevant systems.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195676;658870;MigrWorkers;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Race, Class and Gender of Transnational Urban Labour: Romanian Workers in the Cities of London and NYC;1/09/2015;31/08/2017;;The workings of globalization depend on international labor migration, a phenomenon that is hardly recent but that is, instead, embedded in histories of colonialism, decolonization and neocolonization, divergent conditions of democracy, totalitarianism, militarism and exploitation, as well as in persistent structures of economic disparity among the formal colonial powers and the decolonized world. Contemporary labor migrationthe flows of people in search of labor crossing national boundaries, deeply impacts and transforms the social, economic, political, cognitive and affective landscapes of contemporary life. This project will consider these transformations by examining the transnational migrant labor of workers from Romania such as it unfolds at two central sites of global capitalism, London-U.K. and New York-U.S. The research will feature an historical analysis of the immigrant Romanian labor presence at these sites, while its time frame covers the interval starting in 1989 up to the present day. While labor migration has been a subject of interest for economists, political theorists, geographers, anthropologists and cultural theorists alike, its relevance to affective theory and neoliberal critiques have only recently been addressed. My project seeks to address an analytic gap that refers to the affective dimension of migrational labor by considering not only the economic, political, and historical contexts, but also the impact that immigrants transnational journeys in search for work and their landing in new spaces have on their intimate lives alongside co-nationals as well as alongside other dwellers in the global city. The research project will draw upon recent global changes, more precisely on the global economic crisis, the continued neoliberalization of economies and the pressures towards securitization that affect the cities of London and New York and thus implicitly impact on the lives of immigrant laborers.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF STRATHCLYDE;UK;LONDON SOUTH BANK UNIVERSITY LBG;UK; 195550;658088;NESSY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NEw Science from the phase space of old stellar SYstems;15/10/2015;14/10/2017;;In the last few years our traditional interpretative paradigm of the internal dynamics of globular star clusters (GCs) has been revolutionized by a series of discoveries about their chemical, structural, and kinematic properties. The existence of multiple stellar populations is now regarded as a ubiquitous phenomenon, while for decades GCs have been viewed as the epitome of a simple stellar population. Empirical scaling relations between super massive black holes masses and the velocity dispersion of their host galaxy encourage to consider GCs as host systems of intermediate mass black holes (IMBHs). Finally, little attention has been traditionally paid to the role played by angular momentum in the dynamical evolution of these systems, yet an increasing number of young and old star clusters are now being observed to have evidence of rotation. The astrometric mission Gaia, by allowing the acquisition of the proper motion of thousands of stars in Galactic GCs with exquisite detail, will soon unlock the full phase space of these stellar systems. Such a tremendous observational progress, coupled with recent improvements on the side of numerical simulations, calls for a renewed effort on dynamical modelling. The proposed research program is therefore exceptionally timely and, by means of a unique combination of analytical models, numerical simulations, and the exploitation of state-of-the-art observational data, aims at forming a more realistic dynamical paradigm for this class of stellar systems by providing answers to the following key questions: (1) Are there specific signatures in phase space characterizing the dynamical evolution of multiple stellar populations in GCs? (2) What is the role of the angular momentum in the early and long-term dynamical evolution of star clusters? (3) Is there a dynamical connection between internal rotation and the presence of IMBHs in GCs?;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE UNIVERSITY OF EDINBURGH;UK;;; 195612;658479;SpikeControl;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cerebellar Spiking Model For Real-time Closed-loop Sensorimotor Control;1/09/2015;31/08/2017;;"Understanding how the brain processes and represents information is at the core of experimental studies of the Central Nervous System (CNS). A network of brain subsystems mediates information processing through distributed neural computation and dynamic patterns of neural activity. Over the last decades, studying how these patterns are elicited in the CNS under specific behavioural tasks has become a break through research topic in integrative neuroscience. These specific tasks are related to the concept of embodied cognition, according to which the primary goal of the CNS is to solve and facilitate the body-environment interaction.
This project focuses on the cerebellum, a brain region that plays a crucial role in body-environment interaction, with a primary function related to adaptive motor control and coordination. The functional characteristics of the cerebellum make it a perfect candidate to start modelling and building an embodied nervous system. The cerebellar capability of performing adaptive information processing mediating sensorimotor control will be evaluated in specific tasks. Additionally, the emergence of cognitive-like representations will be studied by focusing on how models of the environment/tools can be acquired through a closed-loop sensorimotor interaction.
This project sets forth a multidisciplinary methodology combining neuromimetic models and embodied neurorobotics. Simulated neural models and robotic experiments will guarantee full access to the system properties, which will be assessed through both qualitative and quantitative performance indicators to facilitate a constructive cross-validation against neurophysiological data. This approach will also allow us to predict new functional roles of specific cell/network/topology properties.
The goal of this project lies on moving forward the knowledge frontiers in integrative neuroscience and biological control, thus boosting the candidate position at the cutting-edge of these fields.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;FR;;; 195692;658971;ACPNMR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural dynamics of acyl carrier protein complexes through combined solution and solid-state NMR;10/09/2015;9/09/2017;;'Antibiotics are a vital part of modern medicine. However, the available arsenal of antibiotics becomes less effective as microorganisms develop 'resistance' against them. The resulting crisis in medicine necessitates development of new drugs. Natural products inspired compounds are a potential solution to this challenge. For example, gladiolin biosythesized by a mulitenzyme polyketide synthase (PKS) was shown to be active against Mycobacterium tuberculosis, a multidrug resistant bacterium that one third of worlds population is infected with. The PKS producing gladiolinum is a good example of multienzymatic assembly lines that due to their modular nature are ideal for genetic manipulation paving the way for synthetic biology approach to produce new drugs (that are difficult to synthesize using chemical methods). However, for such approach to be successful it is crucial to understand molecular level structural and dynamical factors responsible for controlling directionality and specificity of biosynthesis. Neglecting such factors, when modifying PKSs often results in assembly lines that are inactive or dysfunctional. Here we propose to use a novel approach combining state-of-the-art solution and solid-state NMR methods to investigate structure, dynamics and interactions of proteins from module 12 of gladiolin PKS, particularly acyl carrier proteins (ACP12a and ACP12b) and special adapter ketosynthase (KS12), all of them highly required in industrial biosynthesis toolbox. We will use solution NMR to characterize isolated ACPs and solid-state NMR to study ACPs-KS12 complexes (direct structural information is difficult to obtain by solution NMR due to the large complex size). Combining solution and solid-state NMR relaxation methods will allow us to probe protein motions over 6 orders of magnitude providing a comprehensive picture of relevant dynamic changes in ACPs-KS12 complexes.';183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195697;658992;RISH;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Imaging of multiple mRNA targets using SERS nanoparticle labels and in situ hybridization in human cancer tissue sections;6/08/2015;5/08/2017;;Early cancer diagnosis greatly increases the chances for successful treatment and personalised therapy. RNA molecules have emerged as new candidate biomarkers for detecting a wide variety of cancers, due to their critical role in cell growth and development. In situ hybridization techniques for mRNA detection provide detailed spatial and temporal information on RNA expression with single-molecule sensitivity, however the traditional techniques that utilise fluorescence probes and quantum dots lack of high multiplexing capabilities. RISH seeks to develop a methodology that allows sensitive multiplex detection, quantification and distribution of cellular mRNA biomarkers utilising surface-enhanced Raman spectroscopy (SERS) nanoparticle (NP) labels. SERS NP-labels consist of metal nanoparticles modified with a self-assembled monolayer of Raman reporters and are sensitive and robust labels that offer great multiplexing capacity. Molecular beacon hybridization probes specific to mRNA targets will be conjugated to SERS NP-labels to allow optical detection utilising Raman microscopy in human cancer tissue sections. The mRNA expression levels will be correlated with those from fluorescence in situ hybridization and the respective protein expression levels after immunohistochemistry. The research proposal is highly multidisciplinary and includes aspects of spectroscopy, optics, biochemistry, nanotechnology and pathology. The research fellow plans to work closely with experts from both the hospital and the industry to apply this methodology in the diagnosis of initially breast cancer and of different types of cancer at a later stage.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET DUISBURG-ESSEN;DE;;; 195677;658875;GGG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gendered Geographies of Gentrification;1/03/2016;28/02/2018;;"This study aims to shed light on the gendered geographies of gentrification. It examines and compares the mutual reconstruction of space and gender in gentrifying neighborhoods in Amsterdam and Istanbul. It employs Henri Lefebvres theory of space to shed light on different dimensions (conceived, perceived and lived) of the reconstruction of space and gender during gentrification processes. The research uses a comparative qualitative methodology and combines different data collection methods (in- depth interviews, document analysis, participant observations).
With its innovative use of methods and theories across disciplines and its novel focus on production of gender inequalities during gentrification, this research will contribute to the state of the art of urban and gender studies. By doing so, it will not only contribute to the excellence in science but also help increase awareness for gender inequalities, two principles promoted by Horizon 2020 Program.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Leicester;UK;;; 195568;658195;BBFGEN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genetic analysis of rare and common variation in a large Brazilian bipolar family;1/05/2015;30/04/2017;;This proposal describes my aim to use a uniquely large multigenerational family to better understand the genetic underpinnings of mood disorders: the Brazilian Bipolar Family (BBF). The family has a high incidence of mood disorders, featuring diminishing age of onset over generations and assortative mating, whereby many of the marriages in the family are between individuals with a psychiatric disorder. Mood disorders are leading contributors to the global burden of disease. Bipolar disorder is characterized by periods of elevated mood and periods of depression. Major depressive disorder is characterized by pervasive and persistent low mood, low self-esteem and loss of interest or pleasure in normally enjoyable activities. Heritability estimates are 37% for MDD and up to 75% for BP. The current picture for complex disorders is of a genetic architecture consisting of both common and rare variants contributing risk. Genetic studies of mood disorders have not yet individual variants/genes accounting for a large increase in risk. The effect of common variants in the family context is unclear. I propose to utilize the BBF as a unique resource for studying both common and rare variation in mood disorders. Its size offers a powerful means for mapping genetic loci for mood disorders that are individually rare but common within the family. It also provides us with a unique model in which to analyse individual genetic risk profiles, utilizing the large sample size of and predictive ability of previous case-control association studies for each family member into a polygenic risk score. This will also allow me to assess assortative mating, which may act to increase polygenic risk to mood disorders over generations. I will develop an approach which will allow me to incorporate genome-wide case-control study results into family studies something with broad utility for the field. My study will shed light on the genetic pathology of mood disorders, aiding prevention and treatment.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195658;658761;Micropod;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;MICROPOrous Devices for next-generation therapeutic delivery;14/04/2015;13/04/2017;;Dr. Eoin OCearbhaill, a Biomedical Engineer, recently returned to Ireland to become a Lecturer in Bioengineering at University College Dublin. This fellowship will enable him to work with Prof. Michael Gilchrist to develop his career by implementing a research platform based on medical devices for therapeutic delivery, with a specific focus on microneedles. Microneedle transdermal patches are an important advance in the delivery of therapeutics, especially vaccines and biotech molecules. They offer advantages over the classic approaches of hypodermic drug delivery, (needle phobia, risk of needle stick injuries), oral delivery (degradation and poor intestinal permeability of biologics), and traditional skin patches (limited to passive delivery of small molecules). The traditional hollow needle design suffers from a scaling effect, limiting mechanical performance at the penetration depth required for efficient absorption and large molecule delivery. Current microneedle patches targeting transdermal delivery are often prohibitively expensive to manufacture and are prone to mechanical failure. Here, Dr. OCearbhaill proposes the development of microneedle patches with interconnected porosity, aimed at consistent, rapid delivery to dermal tissue, in close proximity to the capillary bed. This platform technology can also be applied to other minimally invasive devices designed to provide controlled therapeutic infusion to precise locations. The applicant will develop porous microdevices, using manufacturing techniques that are scalable and cost-effective, enhancing the commercial value and potential to rapidly translate this technology to patients. The reintegrating applicants proficiency in medical device concept development will synergise with the hosts expertise in computational modelling of penetration in soft tissue and micromanufacturing to aid in the applicants development as a leader in medical device design and innovation.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;IE;;; 195682;658900;EPIMAIZE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Understading the Maize Epigenome and its Role in Development;1/08/2015;31/07/2017;;"Phenotypes are largely determined by genetic factors. However, a given genotype can give rise to very distinct phenotypes, as exemplified by the diversity of cell types in multicellular organisms. This phenotypic plasticity results from epigenetic changes; that is, reversible modifications to the DNA molecule and its associated proteins that modulate gene expression patterns. Epigenetic changes are critical to the establishment of developmental programs, but also to adjust transcription in response to the environment. The latter is particularly important for plant adaptation: owing to a sessile (immobile) lifestyle, plants cannot run away from adversity, and thus adapt to their environment by tuning gene expression in response to changing conditions. Most epigenetic information is erased from one generation to the next, so that new organisms start their life cycle with a fresh potential. However, there are instances in nature of heritable epigenetic marks that can be transmitted to the next generation. Thus, owing to their role in shaping gene expression, and the potential for heritable changes, epigenetic factors are of great interest for plant breeders, in their quest for adaptable, high yielding phenotypes. Most of our current understanding of epigenetic processes in plants has been developed in Arabidopsis, a key model system. However, the Arabidopsis epigenome is rather idiosyncratic, and this knowledge might translate poorly to crops. Here, we will use an interdisciplinary approach combining original genetic materials and bioinformatics to analyze epigenetic regulatory pathways in maize, with a focus on reproductive development. Maize is an important model plant, with a large and dynamic epigenome much more typical of crops. It is also a crop of great economic importance. Better understanding the epigenome of maize will open the door to the manipulation of key agronomic traits, including reproductive development, which is under strong epigenetic influence.";178603,2;178603,2;H2020-MSCA-IF-2014;MSCA-IF-GF;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;FR;;; 195684;658912;Cosmo Plasmas;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Cosmological simulations of radio bright plasmas;1/09/2015;31/08/2018;;"Merging galaxy clusters are among the most energetic events in the Universe. Their interaction generates shocks and turbulence in the ionised cluster medium, driving the amplification of magnetic fields and the acceleration of relativistic particles. This leads to the formation of large diffuse radio sources in some clusters. The next generation of radio telescopes, including the European LOFAR observatory, will revolutionize the field, unveiling a complex picture of these non-thermal processes in clusters. However we still lack numerical simulations to match the capabilities of these instruments. This roots in the complexity of models for MHD-turbulence and cosmic-rays poses challenging demands to simulators. Only recent advances in implementations at the outgoing host and by the applicant make these simulations now feasible.
Hence this project aims to simulate non-thermal radio sources in galaxy clusters with unprecedented detail. The applicant will run the first Eulerian cosmological MHD simulation that resolves the MHD dynamo in clusters including a self-consistent treatment of cosmic-rays in the intra-cluster-medium.
During the outgoing-phase, he will interact with leading experts in the simulation of cosmic ray acceleration and magnetic field amplification at the University of Minnesota. He will be trained in the optimization of grid methods for MHD simulations and algorithms at Cray Inc, a leading vendor of super-computers.
Upon return, the applicant will work with leading theorists and observers at the host to fully exploit his simulations. The comparison with LOFAR data and complementary observations will allow a leap forward in the understanding of the complex mechannisms opeating in the cluster medium.
The project will establish the applicant as a leading numerical researcher in non-thermal cluster physics and a key figure in the interpretation of radio data. Moreover, the results will directly benefit the European radio astronomical community.";244269;244269;H2020-MSCA-IF-2014;MSCA-IF-GF;ISTITUTO NAZIONALE DI ASTROFISICA;IT;;; 195661;658844;Eco-PhyloGeo;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Linking phylogeography to ecology: extracting rules for butterfly biodiversity at large spatial scale;1/09/2015;31/08/2017;;Phylogeography is one of the most integrative disciplines within biology, involving genetics, ecology, geospatial analyses, climatology and computer science. Despite its potential to unravel the determinants that shape biodiversity and to predict the effects of global changes on organisms, phylogeography has not yet been projected onto a unified ecological and evolutionary framework, mainly because most studies rely only on restricted subsets of species without revealing patterns at community levels. The Eco-PhyloGeo project aims to fill this gap for the West Mediterranean butterflies by creating and correlating two datasets: i) a high-resolution assessment of the genetic diversity for the mitochondrial gene COI of all the butterfly species occurring in this area, and ii) a dataset for the main ecological traits of all European butterflies. A substantial amount of the data are already available to the ER and the supervisor, and the datasets will be completed by training-through-research. In addition, the creation of new phylogeographic indexes will allow the partitioning of species genetic structure over space in nestedness and turnover components. The project has two ambitious yet feasible objectives: 1) Complete and freely release the DNA and the species traits datasets together with a R package to allow a wide use of these resources in biogeography, ecology and taxonomy. 2) Provide for the first time a mathematical background to link species phylogeography with ecological traits for an entire and large animal taxon. Given the novelty of the analyses and the unprecedented geographic resolution and taxonomic completeness of the datasets (around 12,000 sequences and about 20 ecological traits for 450 butterfly species), the Eco-PhyloGeo is expected to have a great impact on the scientific community represent a key step towards drawing out general rules in phylogeography and ultimately determining biodiversity patterns.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195828;659667;LANDS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Large Area Nanoparticle Deposition System;12/08/2015;11/08/2017;;I intend to travel to the University of Oxford and the lab of Dr. Moritz Riede and build a second generation version of the Large Area Nanoparticle Deposition System (LANDS) that I have designed and built during my PhD studies at Stanford University in the USA. This will be a flexible, particle-agnostic system that will be capable of depositing uniform films of nano- and micro-particles from solution. It is designed to emphasize scalability, high throughput and large area film uniformity and will be compatible with low-temperature flexible plastic and foil substrates and the devices built on them. Once complete, I will initially use the LANDS to deposit nanostructured thin films of metal nanowires to form transparent conductive electrodes for photovoltaic applications. I will continue to develop and explore the use of such metal nanowire films as replacements for industry standard transparent conductive oxides such as indium tin oxide (ITO) and fluorine doped tin oxide (FTO) especially in flexible devices.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195657;658795;DOGMITE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The unique dioxygenases of phytophagous spider mites: new enzyme players in plant-herbivore interactions?;1/09/2015;31/08/2017;;Detoxification of poisonous xenobiotics in animals is typically performed by multi-gene enzyme families. Within arthropods, only insect genomes have been studied in detail where these families are well characterized. I recently uncovered a new enzyme family in the genome of a non-insect arthropod, the extremely polyphagous plant-feeding mite Tetranychus urticae and showed that this proliferated family was acquired via horizontal gene transfer from a fungal donor. The family codes for intradiol ring cleaving dioxygenases which cleave a particular set of aromatic structures, commonly found in pesticides and plant metabolites. Here, I propose to functionally characterize this exciting new gene family and to elucidate its role in xenobiotic detoxification, with a focus on plant secondary metabolites. First, to create a general picture, I will map the in situ expression of dioxygenases and time their responses to plant-derived secondary defense metabolites. Second, guided by preliminary results, I plan to study how these new herbivore enzymes counteract polyphenol oxidases, well-known plant defense enzymes that act against herbivores and target the same class of substrates. State-of-the-art plant transformation experiments will be performed in order to meticulously dissect their counterplay. Finally, by means of an unbiased multi-layered strategy, I will functionally characterize these new dioxygenases. Dioxygenases will be introduced into biological systems by functional expression in E. coli or insect cells, and by genetically transforming Drosophila. Cutting-edge differential metabolomics will identify the substrates and reaction products. By means of this project, I expect to unravel the selective advantage of this new family for phytophagous mites and open up avenues to exciting biotechnological applications which I expect to extend well beyond agriculture.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195724;659123;MOLMAG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New Spin for Molecular Magnets;31/08/2015;30/08/2017;;One of the next great challenges facing Europe is the development of new materials that reduce our dependence on critical metals such as rare earth elements (REEs). REEs have revolutionized both magnets and microelectronic industry, but the lack of economically exploitable deposits combined with geopolitical concerns have led to an impending resource problem. Molecular magnetic materials based on organic radicals represent one attractive alternative to REEs as the use of organic compounds would allow chemical processing rather than metallurgical. The challenge lies in developing radicals that are indefinitely stable under standard ambient conditions but still structurally tunable to attain the desired properties. This research project investigates two families of stable organic radicals and their metal complexes as new components for molecular magnetic materials. The radicals are based on the 1,2,4-triazinyl framework which, despite a long history and extreme stability, has only recently raised interest in materials oriented research. The potential of the investigated radicals will be exploited in two approaches. First, co-crystallization of the triazinyl radicals is studied as a novel design strategy to enhance intermolecular ferromagnetic interactions in organic radicals, and second, coordination of the radicals to paramagnetic metal centres is used as further means to control spin interactions through intramolecular spin coupling. The proposal combines the research ideas and synthetic skills of the experienced researcher with the knowledge and infrastructure of the supervisors and their hosting institutions, creating an interdisciplinary project that spans multiple fields from organic and organometallic synthesis to computational chemistry and condensed matter physics. Through the synthesis of new building blocks for real-world materials, the project will not only enhance the understanding of molecular magnetism but also the career development of the MSC fellow.;191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JYVASKYLAN YLIOPISTO;FI;;; 195597;658363;ARENAVIRUS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular mechanisms of arenavirus cell entry and antibody-mediated neutralization;1/05/2015;30/04/2017;;"Over the last decades, multiple arenaviruses have emerged as zoonotic human pathogens. They cross the species barrier from their natural rodent hosts to humans and cause severe human disease. A key determinant of viral zoonotic transmission is the ability to bind the receptor molecules displayed on the surface of the host cell. Despite the threat these viruses cause to public health, little is known of how they infect the host and how they are targeted by the immune response. Furthermore, the treatment and prevention options are currently extremely limited.
Using techniques in structural biology, virology, immunology and cell biology, the proposed work aims at demonstrating the molecular mechanisms by which arenaviruses attach to human cells and are neutralized by the humoral immune response. First, crystallographic analysis of viral attachment glycoproteins alone and in complex with functional cellular receptors will be performed. Second, recombinantly derived viral glycoproteins will be used as immunogens for generation of specific monoclonal antibody libraries. The co-crystal structures of viral glycoproteins with cross-reactive, neutralizing antibodies, carefully selected using cell-based assays, will reveal the structural basis of antibody-mediated arenavirus neutralization. Therefore, by analogy to the development of antibody-based therapy against Ebola virus, the outlined multidisciplinary investigation will enable the rational design of antiviral reagents and vaccines.
The cross-disciplinary expertise, training and infrastructure available in the host and partner organizations will allow the Researcher to establish herself as a highly-skilled expert in molecular and structural virology. As an independent, multifaceted scientist, she will be able to make a tangible contribution to the development of novel antiviral therapies, thus improving the public health and economy and adding to science base both in Europe and worldwide.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195635;658645;S4ILS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Solar Sailing for Space Situational Awareness In the Lunar System;8/08/2015;7/02/2018;;"Solar Sailing for Space Situational Awareness In the Lunar System (S4ILS) will deliver radically new orbits in space by exploiting the potential of solar sailing, an exciting new type of spacecraft propulsion. As a flight-proven technology, a solar sail spacecraft rides on sunlight the way that sailboats ride on the wind. Its renewable attribute makes solar sailing a truly mission enabling technology, which is exploited by S4ILS to further one of Europes key space priorities, Space Situational Awareness (SSA): the new orbits will improve our ability to keep ground and space assets safe from natural cosmic hazards (e.g. space weather) and man-made threats from space (debris).
S4ILS offers novelty of research and solutions to global challenges, as well as excellent training of the Experienced Researcher (ER) by a world-leading astrodynamics institute at the University of Colorado, USA, and by one of Europes top universities of technology, TU Delft, the Netherlands. The entire team of renowned experts in astrodynamics, low-thrust space mission design and SSA built around the ER enables a unique fusion of knowledge and a pool of resources, creating the best environment for the ER to fully develop her potential.
The fundamentally new orbital dynamics that S4ILS will deliver combined with the compelling application of SSA, that impacts industries far beyond the aerospace sector, will put solar sailing firmly on the European space agenda and will underpin the need for further European solar sail technology development. Influencing decision makers is ensured by collaborating with the American space agency (NASA) and through a secondment at the European Space Agency. These opportunities expose the ER to a vast international network, crucial for starting an independent research career. In summary, the Fellowship allows the ER to emerge as a leader in game-changing developments in space technology and applications and provides a platform for a successful academic career.";202897,2;202897,2;H2020-MSCA-IF-2014;MSCA-IF-GF;TECHNISCHE UNIVERSITEIT DELFT;NL;;; 195666;658813;Old and New;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;How Old and New Media Influenced Each Other and Society in Iceland during the 16th and 17th Centuries;1/06/2015;31/05/2017;;"The influence of a the new medium of print on the old, existing medium of handwriting has never been examined before. The printing press came already around 1530 to Iceland and the earliest printed books were strongly influenced by handwritten manuscripts, which is well documented. A phenomenon which has not yet been analysed is that, as time went on, books in return influenced manuscripts. Manuscript production did indeed not stop after 1530, but grew to new quantitative and qualitative heights, including features of printed books such as title pages. I therefore propose to conduct a study on the relationship between books and manuscripts of the 16th and 17th centuries. The focus will be on title pages, as they are a truly innovative feature of printed books that we also find in post-Gutenberg manuscripts.
The objectives of this project concern:
a) The influence of a new medium on an existing medium
b) The utilisation of features of the new medium to achieve specific aims and goals
c) The impact of this utilisation on society
Methods to conduct the study of title pages and their sociological impact include content analysis from literary studies, quantitative codicological analysis from book and manuscript studies, and iconographic/iconologic analysis from art history.
This project has ground-breaking potential. It will provide insight into the ways features of new media were incorporated into existing media and how they were utilised. It will be the first systematic survey of its kind in Iceland and, concerning the influence of printed books on post-Gutenberg manuscripts, internationally. It will also be one of the first systematic interdisciplinary studies.
It will be the forerunner of a larger project about Icelandic book and manuscript history and media changes with more researchers involved. The beneficiary has perfect conditions for interdisciplinary research and career development at the host institution and secondment and will complete the first step toward a full professorship.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN;AT;;; 195720;659104;LeSoDyMAS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Learning in the Space of Dynamical Models of Adrenal Steroidogenesis LeSoDyMAS;13/07/2015;12/07/2017;;"To date most successful machine learning techniques for the analysis of complex interdisciplinary data predominantly use significant amounts of vectorial measurements as input to a statistical system. The domain expert knowledge is often only used in data preprocessing and the subsequently trained technique appears as a black-box, which is difficult to interpret or judge and rarely allows insight into the underlying natural process. However, in many bio-medical applications the underlying biological process is complex and the amount of measurements is limited due to the costs and inconvenience for the patient. The main aim of this project is the formulation of a generalised framework for learning in the space of probabilistic models representing the complicated underlying natural processes with potentially very few measurements. This includes the development of a similarity measure for posterior distributions, task-driven model simplification and a new learning paradigm to combine those modules. The method will be developed for the prediction of steroid flow in the treatment of Congenital Adrenal Hyperplasia (CAH) incorporating dynamical models of Adrenal Steroidogenesis. With the successful execution of this project we expect not only better prediction performance for individual treatment success, but also deeper understanding of the pathophysiologic processes due to the incorporation of the pathway models. The project combines the expertise of the Fellow (Dr. Bunte) in task-driven similarity learning and dimensionality reduction with the expertise of the Host Coordinator (Prof. Tino, The University of Birmingham (UoB)) in probabilistic modelling, dynamical systems and model-based learning. The UoB and all participants (University of Sheffield,Warwick and the company Diurnal Ltd) provide further bio-medical
and modelling expertise, and have already successfully collaborated in previous projects, including the clinical data targeted in this proposal.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195818;659624;EDD Project;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;A new EDD detector will give a knowledge for crystallography with the objective to understand nanostructures and for the development of new materials;1/04/2015;30/09/2015;;"The year 2014 has been proclaimed, by UNESCO, the International Year of Crystallography. Irina Bokova Director-General of UNESCO said : Crystallography is essential to sustainable development, to tackling global challenges in food, in water, in the environment, in energy, in health. It is by understanding the basic forms of matter that we can transform it for the better, develop new materials, design new drugs against diseases, improve water quality. Development needs innovation, and in most cases, scientific innovation needs crystallography.
Crystallography underpins the development of practically all new materials, from everyday products like computer memory cards to fat television screens, cars and aeroplane components. Crystallographers not only study the structure of materials but can also use this knowledge to modify a structure to give it new properties or to make it behave differently. In fact, crystallography has many applications.
EBSD (Electron BackScatter Diffraction) is the technique by which an SEM (Scanning Electron Microscope) can be used to evaluate the micro and nanostructures of a specimen based on crystallographic analysis. EBSD provides absolute crystal orientation information and allows identification of phases and discrimination between phases in materials, texture measurements, boundary characterization and deformation measurements. Today, EBSD is applied across a wide variety of research fields: in the metals processing industry, the aerospace, nuclear, automotive and microelectronics industry, earth sciences etc.

The EDD technique is 10 years in advance compared to actual EBSD technique and this new technique will allow the SMEs and materials manufacturers to better understand their crystallography, to uptake of nanostructure modifications under strain, allow the observation of crystallography during the development of new materials and allow the calculation of prediction on the ageing of materials.";71429;50000;H2020-SMEINST-1-2014;SME-1;NEWTEC SCIENTIFIC;FR;;; 195813;659575;MicroFrac;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Visualization and modelling of fracture at the microscale;1/07/2015;30/06/2016;;"In recent years, large spills from oil pipelines and tankers, leaks from nuclear reactors and the constant need for lighter and stronger materials in the transportation industry illustrate the need for materials with improved fracture resistance. Recent reports also suggest that the costs of fracture in Europe reach 4% of Europes gross domestic product which mean about 500 billion Euros. These facts show how fracture of structural materials can have detrimental effects in terms of health and safety, the environment, and the economy. One key elements that prevents better fracture predictions is a lack of information on fracture at the microscale. Indeed, fracture takes place by the formation and growth of microvoids and how these voids grow is still unknown and prevents the development of accurate fracture models. This proposal aims at providing a significant contribution towards our understanding of fracture at the microscale through a combination of state-of-the-art experiments and models.

Microvoids will be introduced in metallic single crystals and their growth will be followed in-situ at high resolution. The effects of void size and crystal orientation will be investigated and the results will be used to validate dislocation dynamics and crystal plasticity models. The outcomes of the project will be new experimental evidence of fracture at the microscale and the creation of an improved crystal plasticity model that can take into account size effects to better predict metal fracture.";85060,8;85060,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACION IMDEA MATERIALES;ES;;; 195709;659033;MELANOPARK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating the LRRK2-melanin connection through phosphoproteomics of isogenic melanoma cells;1/07/2015;30/06/2017;;LRRK2 is a multi-domain protein, which uniquely possesses both protein kinase and GTPase catalytic activities. Autosomal dominant mutations of LRRK2 represent one of the principal genetic risk factors for Parkinsons Disease (PD), which results in preferential loss of neuromelanin containing, dopaminergic neurons from the substantia nigra. The (patho)physiological roles of LRRK2 are currently unclear. However, it has been linked to the regulation of endolysosmal membrane trafficking through complex formation with other PD-related gene-products (Rab7L and Vps35). LRRK2 is also highly expressed in skin pigment cells (melanocytes), which specifically produce melanin within the lysosome-related organelles known as melanosomes, in a process referred to as melanogenesis. Here we propose to examine the substrates and function of LRRK2 in pigmented melanoma cells. We will generate a MNT1 cell panel expressing PD-associated mutations of LRRK2 using CRISPR/Cas9 gene editing and characterise the respective (phospho)proteomes LRRK2 inhibitors from total lysates and from melanosome-enriched fractions using quantitative mass spectrometry. Melanosome biogenesis itself will be compared across the panel using electron microscopic procedures established by the experienced researcher as well as other organelle associated parameters (e.g. contacts with mitochondria) and trafficking pathways linked to Vps35 and Rab7L. The aim is to establish LRRK2 substrates or cellular consequences of activity, which may be specific to melanin-containing cells and link these to PD or to the increased incidence of melanoma observed in PD patients.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF LIVERPOOL;UK;;; 195535;658025;CRISIS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Coastal flood risk in Europe and the socio-economic impacts in a changing climate;1/03/2016;28/02/2018;;A large portion of the coastal population worldwide, including Europe, is already vulnerable to extreme high sea level events. In the future it is expected that climate change will increase coastal flood risk making costly adaptation inevitable. In order to help develop robust and flexible coastal management strategies, decision makers need to explore how, when, and where future changes in the physical environment will require immediate action. This is aggravated by the existence of large uncertainties in climate projections. Impact assessment models, such as the Dynamic Interactive Vulnerability Assessment (DIVA) model, have been used extensively to assess the socio-economic impacts associated with coastal flooding under climate change and to explore the benefits of mitigation, adaptation, and migration. However, because the DIVA model is applied at broad scales, it is based on a number of significant assumptions. Most notably, present-day return water levels (one of the key forcing parameters in the model) were derived using a simple global approach. Moreover, decadal variations in storminess and associated changes in future return water levels were ignored. Storm surges and river floods were assumed to be fully independent and vertical land movement rates were approximated with a global glacial isotactic adjustment model ignoring other potential contributors, such as land subsidence associated with ground water extraction. These shortcomings will be specifically addressed within the fellowship at the European level. The results will be used along with existing data bases and model infrastructure to develop a regional version of DIVA. The latter will be applied to perform the most comprehensive and realistic (in terms of temporal variations) mesoscale flood risk analysis of the European coastline to date, accounting, throughout the fellowship, for the full range of inherent model and scenario uncertainties.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SOUTHAMPTON;UK;;; 195582;658277;DCmucoHIV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;HIV/SIV exploits DCs in mucosal infection: mechanisms of transmission and modulation by semen associated factors;1/07/2015;30/06/2017;;"Worldwide a large proportion of all new cases of HIV-1 infection are due to anal sexual intercourse, being the anal/rectal as well as distal colonic mucosa a site of viral uptake and entry. I recently demonstrated that intestinal lamina propria resident DCs migrate towards and extend cellular processes between the tight junctions of columnar epithelium through a CCR5-dependent mechanism, take up R5 but not X4 HIV-1, and then transfer infection to susceptible T cells. Although in mice CX3CR1\DCs are deputed to shuttle microbial antigens, there is no clear idea on which subsets of DCs are located in the human GI tract, are involved in HIV infection and contribute to virus spread, its presentation or possibly to its reservoir. Moreover, the ability of DCs to shuttle the virus across the mucosa may be largely modulated by components of semen, the natural vehicle of HIV during sexual transmission.
To fill these gaps I propose a comparative study in macaques and humans using a multidisciplinary approach, which will unravel the mechanism associated with rectal transmission of HIV/SIV by DCs and their modulation by semen.
Specific objectives will be:
1. Define the subsets of DCs and the molecular mechanism(s) through which DCs directly sample HIV-1/SIV through the intestinal epithelium and facilitate the spread of the infection.
2. Define the impact of semen on HIV/SIV-induced DCs migration across the epithelium.
3. Determine the ability of lamina propria DCs subsets to migrate across the intestinal epithelium and to redistribute to draining lymph-nodes following in vivo exposure of Cynomolgus macaques to infectious pathogenic SIV.
We expect to characterize the early events of DC-mediated intestinal transmission of HIV/SIV and thus contribute to the knowledge base needed to identify, evaluate and develop novel agents or strategies to prevent mucosal HIV transmission";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;;; 195620;658536;VIVO_MECH_COLL_MIGRA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biomechanical analysis of in vivo directional collective migration;2/02/2016;1/02/2018;;"Directional cell migration is important in physiology and pathology. Molecular mechanisms regulating directional migration are largely studied; but the role of mechanical cues and their interplay with biochemical signals during directional migration is poorly understood. To address this we will use Neural Crest (NC) cells, a highly migratory embryonic cell population. Evidence about how chemical cues regulate NC migration has accumulated, but nothing is known about the biomechanics of NC migration. This proposal focuses on understanding how NC interacts with the mechanical cues from its environment during directional migration in vivo, as well as understanding the molecular nature of this interaction. Thus, our aims are: Aim 1) to study the role of mechanical cues in vivo and their interplay with chemical signals during in vivo NC migration. Aim 2) identify the molecular mechanism by which the mechanical properties of the substrate are sensed and translated as signals into the NC, and to test the role of Nedd9 as a key component of this process. (Nedd9 appears in a screening that I performed to identify potential NC mechanosensors).
These studies will provide new tools and information on the role of mechanical cues during directional migration in vivo, how these cues interact with chemical guidance, how are they integrated as cellular signalling within cells? These questions are poorly studied aspects of cell migration, thus our results will be a real contribution to the state-of-the-art in cell migration. This multidisciplinary proposal is will be mutually beneficial, providing the host and me with new collaborations. A research line will be created in ERA with NC as a model to study biophysics of migration in vivo. I will complement my current skills with new knowledge in biophysics of cell migration and managerial skills; this will have a countless impact in the career that I project as an independent researcher in the cell migration field.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195644;658712;GLYCODIS3;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genetic correction of glycogen debranching enzyme deficiency in Glycogen Storage disease III: a proof of concept study;1/01/2016;31/12/2017;;"Glycogen storage disease III (GSD III) is a rare (1:100,000) autosomal recessive disorder that results from the deficiency of the glycogen debranching enzyme (GDE). The major cause of morbidity is associated with the muscle accumulation of glycogen, which leads to progressive myopathy. A dietary treatment with frequent meals high in carbohydrates, slows the progression of the pathology that is however inevitable.
There is no cure for GSD III, the recent development of a mouse model lacking GDE activity, which recapitulates the human condition, represents a unique opportunity to develop and test novel therapies for the disease.
Here, we propose to perform a proof-of-concept study of an adeno-associated virus (AAV) vector-mediated gene therapy for the treatment of GSD III. AAV gene therapy has been successfully used for the correction of several genetic diseases in animal models and humans. One of the main limitations of AAV vectors is that they cannot package vector genomes significantly larger than 5kb. Due to the length of the sequence of the GDE enzyme (4596 bp), we engineered a dual-vector system with a recombinogenic sequence to drive reconstitution of the full-length GDE sequence. In alternative to this strategy, we engineered also a truncated GDE that can fit in a single AAV.
Because GSD III is both a liver and muscle diseases, and because the liver is involved in glycogen metabolism and, ultimately, in the supply of glucose to the muscle, we will test two main therapeutic strategies to treat GSD III, consisting of constitutive or liver-specific expression of the transgene. The rescue of the GDE enzyme deficiency will be carried out in vivo in a GDE KO mouse, and in vitro in human iPS cells-derived hepatocytes and myocites. We will generate fibroblast-derived iPS cells from GSD III patients and the pluripotent cells will be successively differentiated in hepatocytes and myocites.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASSOCIATION GENETHON;FR;;; 195641;658701;ImmunoFarm;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;IgA-based oral therapy for protection of piglets against infection with enterotoxigenic E. coli.;1/05/2015;30/04/2017;;Postweaning diarrhoea (PWD) in pigs is responsible for important economic losses in the global pig rearing industry. This illness is predominantly caused by enterotoxigenic E. coli strains carrying the F4 (ETEC-F4) and F18 (ETEC-F18) fimbriae. There is no treatment available to fight PWD except using antibiotics. However, the prophylactic use of antibiotics is forbidden in Europe and is expected to become forbidden in the rest of the world because of increasing abundance of resistance genes. Delivery of sIgA to mucosal surfaces as passive immunotherapy agent is a very promising strategy to prolong maternal lactogenic immunity against post-weaning infections. The aim of this project is to produce sIgA-like anti-ETEC antibodies in a cost-effective platform. Twenty different anti ETEC-F18 antibodies in a sIgA-like format will be engineered from phage display-selected variable domains (VHHs) currently available in the host institute. The synergistic or additive neutralisation effect of oligoclonal antibody cocktails will be evaluated using ETEC-F18 in vitro villus adhesion assays. The different antibodies will be produced first by transient expression in Nicotiana benthamiana and second in seeds of Arabidopsis thaliana transformants. An in vivo ETEC-F18 challenge will then be performed using two groups of piglets, one receiving the most effective seed-derived feed formulations and the other one receiving regular feed (negative control group). The sIgA antibodies of the elite oligoclonal formulation will then be transferred to biosafe soya seeds as production platform. These steps will lead towards the development of scalable procedures to obtain a cost effective bulk production of a feed based prophylaxis against ETEC.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;VIB;BE;;; 195520;657876;ABRUPT;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantifying Abrupt Biotic Responses to Palaeoclimate Change;11/04/2016;10/04/2018;;"Climate change in the 21st century is predicted to push ecosystems across ecological thresholds, potentially resulting in abrupt ecosystem change into new and irreversible states. Ecological theory proposes that non-linear biotic responses are the result of a complex interplay of feedbacks, thresholds and interactions that operate over decades to thousands of years. As a result, standard ecological research methods are generally unable to quantify key ecological dynamics that are relevant for forecasting abrupt ecological change and there is a critical need to integrate long-term ecological data with process-based models. This will result in improved forecasting of climate-change impacts on ecosystems at both local- to global-scales. Such studies will play a critical role in understanding the intrinsic factors (e.g. climate-vegetation feedbacks) that can result in non-linear biotic responses to climate change.
Sediments are natural data-loggers that preserve the remains of plants and animals over thousands of years. They provide a unique resource for answering current high priority questions related to predicting future ecosystem change because they are the only way to obtain empirical information relevant for understanding long-term ecological dynamics and functioning. In this project I will develop an interdisciplinary framework that integrates state-of-the-art process-based modelling with new high-quality palaeoecological information to quantify the factors that result in non-linear responses to climate change. I will apply the framework to a major vegetation transition in the past: the sclerophyll-rainforest transition in north-east Australia that occurred between 10 and 7 thousand years ago. I will develop this case study for proof-of-concept of a new interdisciplinary framework. This will result in a greater understanding of non-linear biotic responses to climate change.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SENCKENBERG GESELLSCHAFT FUR NATURFORSCHUNG;DE;;; 195606;658437;ENMMCL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Efficient Numerical Modeling of Moving Contact Lines under Non-isothermal Conditions;6/10/2015;5/10/2017;;"A moving contact line (MCL) is a moving line of intersection between a fluid/fluid interface and a solid wall. MCLs are central to a wide range of flows in nature and industry, however, their modeling has been a classical difficulty, especially under non-isothermal conditions. The project will tackle this challenge and we will develop a novel computational model enabling simulations of non-isothermal flows involving MCLs with unprecedented efficiency. The model borrows the idea from the large eddy simulation in turbulence modeling; it will resolve the macroscale flows only while model the effect of MCLs using non-isothermal hydrodynamic theories, which will also be developed in the present project. We expect that the model can lead to a reduction of computational effort by nine orders of magnitude for three-dimensional flows, compared with direct numerical simulations using a uniform grid, and it will therefore enable affordable simulations of practical flows in industry.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195591;658341;NBSC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neural basis of semantic control;1/02/2016;31/01/2018;;"Every form of semantically-driven human behavior is supported by semantic control, which refers to executive processes that regulate access to semantic knowledge. To understand everyday verbal and nonverbal activities (e.g., speaking, object use), as well as impairments after brain damage, it is crucial to establish how semantic control is implemented in the brain.
In general terms, semantic control is known to be supported by a network of frontal-parietal-temporal brain areas. However, the exact contribution of each area to semantic control and whether each is specific to semantic control or part of a general cognitive control function, remain to be determined. Besides advancing basic science these questions are clinically important as different parts of the network can be affected by brain damage.
The goal of this project is to answer these questions by carrying out two fMRI investigations and one TMS study, on the very same participants. This novel combined multimethod approach ensures that this project will provide convergent evidence on these key issues. To find specializations related to different types of semantic control, we will first run an fMRI study with a semantic association task comparing two different conditions that differ only for the type of semantic control processes required. To explore the extent to which these functional specializations are dedicated to semantic control, we will run a second fMRI study with a non-semantic association task and we will compare control effects across semantic and non-semantic tasks. To test whether the brain areas revealed by fMRI have a necessary role for different types of semantic control, we will run a TMS study during a semantic association task. Thus, additional innovative aspects of this project reside in measuring neural priming disruption effects with fMRI and in using online single-pulse TMS, to allow more precise evaluation of the contribution of each area and its time-course in semantic control.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195646;658718;MUCDIFF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Competition between the enteric pathogen Clostridium difficile and the commensal members of the gut microbiota for mucosal sugars;1/09/2015;31/08/2017;;Clostridium difficile is a Gram-positive, anaerobic bacterium that relies on the disturbance of the normal gut microbiota to colonize the human intestinal tract and cause infection and disease. In the last decade new strains of C. difficile have emerged to cause outbreaks of increased disease severity and higher recurrence and mortality rates. C. difficile infection (CDI) is becoming refractory to the conventional antibiotic treatments and probiotic-based approaches are viewed as promising alternative therapies to effectively treat CDI. The development of such bacterial-based treatments requires the identification of the mechanisms by which the commensal members of the gut microbiota are able to eradicate C. difficile, as well as of the identity of the members of the gut microbiota that orchestrate those mechanisms. Since nutrient competition is an important mechanism by which the colonic microbiota suppresses the growth of many enteric pathogens, I focus here on competition for limited nutrient sources, such as the gut mucosal sugars N-acetylglucosamine (GlcNAc) and sialic acid, as a mechanism by which the members of the gut microbiota can eradicate C. difficile. I will investigate in detail the importance of GlcNAc catabolism, both alone and in combination with the catabolism of sialic acid, for C. difficile expansion in the gut. Furthermore, by combining stable isotope probing (SIP) and fluorescence in situ hybridization (FISH) with high resolution secondary ion mass spectrometry (NanoSIMS) I propose to identify commensal members of the gut microbiota that can efficiently catabolize these mucosal carbohydrates in vivo and to evaluate the ability of the identified organisms to outcompete C. difficile. Thus, this work will contribute to elucidate the mechanisms by which the gut microbiota prevents C. difficile colonization and to identify members of the gut microbiota that can be the basis for an effective, safe and standardized treatment to cure CDI.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195705;659022;GENMETASTEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;GENOMIC AND METABOLIC REGULATION OF METASTATIC CANCER STEM CELLS;1/09/2016;31/08/2018;;The major causes of cancer deaths are relapse and resistance to current therapies associated with the presence of cancer stem cells (CSCs) and metastatic growth in distant organs. CSCs have the ability to self-renew and differentiate in non-CSCs. In breast cancer, acquisition of stemness properties has been closely related to epithelial-mesenchymal transition (EMT), a key process in cancer invasion and metastasis triggered via Rho-ROCK mediated actomyosin contractility. Interestingly, in melanoma, transition from elongated-mesenchymal to amoeboid mode of movement (MAT) driven by Rho-ROCK signalling has been associated with increased stemness. Furthermore, preliminary data from host lab shows that actomyosin cytoskeletal regulates glutamine metabolism in both melanoma and breast cancer cells. Metabolic cues participate in stem cell self-renewal regulation, suggesting that, in very contractile cells, the regulation of EMT, metastatic spread and tumour initiation might be functionally linked to stemness via metabolic clues. Nevertheless, how very contractile cells regulate genes involved in all these processes remains unexplored. As increasing contractility via EMT in carcinoma cells or via MAT in melanoma cells correlates with increasing stemness, we hypothesize a molecular link between the pathways regulating both migration and stemness abilities, which will be maintained across tumour types (from carcinoma to melanoma). The main goal of this proposal is to understand how tumour cells can acquire stem cell traits to successfully metastasize and how this can be regulated by the actomyosin cytoskeletal by using an interdisciplinary approach that combines state-of-the-art techniques in molecular and cellular biology, biochemistry, in vivo imaging and animal models. This will allow to identify key important genes regulating both stemness traits and metastatic spread with the ultimate goal of unravelling novel drug targets and prognostic markers of distant relapse.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195690;658953;MIP4CELL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular Imprinting mediated regulation of cell behavior and related biomedical applications;1/03/2016;28/02/2018;;"Tissue engineering or regenerative medicine, with its ultimate aim of developing true human replacement parts, has recently made enormous progress. The field refers to the use of human cells to replace or regenerate tissues or organs. Ideally, biomaterials for tissue engineering should efficiently mimic functionalities of the natural extracellular matrix (ECM). Hence surfaces of biomaterials should be engineered for dynamic control of cell behaviour. The objective of this proposal is to exploit molecular imprinting as a dynamic methodology for biofunctionalization and tissue engineering. Building on our previous proof of concept demonstration of systems for cell sheet harvesting, we expect to hereby obtain dynamic biofunctionalization of surfaces and overcome limitations of currently used methodologies (e.g. ligand leaching in non-covalent approach, loss of bioactivity in covalent approach, and lack of means for dynamic control of cells adhesion in both). The specific objectives of the proposal are as follows:
1) To establish bioimprinted hydrogels with thermo-responsive affinity to bioactive cell adhesive peptide as a generic platform for dynamically regulating cell adhesion and migration.
2) To develop thermo-responsive DNA aptamer imprinted hydrogels for dynamic recognition of specific cells via cell-aptamer interactions, and using as a platform for capture and release tumor cells.
Therefore, this proposal will mimic the in vivo dynamic characters of the ECM and allow to obtain controllable cell behaviours in artificial biomaterials, thus having potential applications in medical diagnostic and regenerative medicine.
Bringing together a highly talented and creative experienced researcher, who has already contributed decisively to the field, with a leading research group in the field of molecular imprinting and biomedicine will allow for the aforementioned objectives to be successfully accomplished.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MALMOE HOEGSKOLA (MALMOE UNIVERSITY);SE;;; 195629;658589;MWMI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mesoscopic characterization of human white-matter: a computational in-vivo MRI framework;1/12/2015;30/11/2017;;"The goal of this highly multi-disciplinary and inter-sectional proposal is to develop a novel computational in-vivo MRI technique, namely Mesoscopic White-Matter magnetic resonance Imaging (MWMI). MWMI will measure 5 specific micro-scale metrics at a mesoscopic spatial resolution of about 300 ?m: myelin, iron, water concentration, axonal density, and the ratio between inner and outer fiber diameter (g-ratio) - a surrogate measure for its conductance speed. Conventional quantitative MRI (qMRI), such as Diffusion Tensor Imaging, can detect but not determine the origin of microstructural changes, whereas MWMI will both detect microstructural changes and identify their origin (e.g. whether learning leads to axonal reorganization or myelination).
To facilitate MWMI, 3 major methodological innovations will be developed:
(a) Advanced biophysical models: Unlike existing biophysical models (e.g. axonal diameter model), which are ill posed due to the restriction to one qMRI mechanism, MWMI will combine 4 different qMRI mechanisms (relaxometry, diffusion MRI, magnetization transfer, and proton density imaging) to better condition its models.
(b) Spatial integration: Novel physically-informed artifact correction methods will allow spatial integration of high-quality maps from 4 different qMRI techniques with sub-voxel accuracy.
(c) Mesoscopic resolution: Unlike standard biophysical models and qMRI, the unprecedented resolution of MWMI will allow estimating micro-scale metrics within the white matter that are unbiased by partial volume effects.
The pain circuit, which is a fundamental and well-described sense, will be used to demonstrate the feasibility of MWMI. Longitudinal MWMI be performed to measure micro-scale correlated of nociceptive long-term habituation in the spinal cord, the first and crucial anatomical structure associated with pain.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF;DE;;; 195798;659468;Transnational Localism;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transnational Localism and Music after the two World Wars: the case of Francis Poulenc;1/09/2015;31/08/2017;;"This project looks at the role composers played in the construction of European culture in the aftermath of two World Wars. Taking Francis Poulenc as an example of a French composer who experienced war twice, it looks at his creative responses to the wars. It prioritises the musical and cultural significance of localised urban, suburban and rural places in shaping a distinctive musical and national identity, an identity that was recognised by his contemporaries as representing a generation; it also scrutinises his international activities in pursuit of cultural and artistic co-operation, collaboration and exchange. The project includes a study of Poulencs UK connections, using understudied archival materials to explore his collaborations with composers such as Britten and Lennox Berkeley, his presence in concert life and his clandestine WWII activities with the BBC. It also examines the significance of the European-American artistic exchanges from the post-WWI period as a form of cultural co-operation and propaganda. Transnational Localism shows the extent to which creative artists reflected the trauma of conflict, contributed to peace-building and to national and European identity on a cultural level and participated in politics without needing to be explicitly politically engaged.

Musicology was identified as an area of strategic priority by the European Science Foundation, Standing Committee for the Humanities in 2008. This project responds to this challenge by exploring the role of music in shaping identities on individual, generational, national and European levels. It also takes the inherent interdisciplinary nature of musicology a stage further by designing a training programme and research project that is multidisciplinary with the aim of establishing research cooperation that is of mutual benefit to European and Anglophone scholarly traditions in the Humanities and Social Sciences.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL NORTHERN COLLEGE OF MUSIC;UK;UNIVERSITY OF KEELE;UK; 195694;658982;CHAOS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nonlinear Compensation in Hybrid Raman/EDFA Amplified Optical Systems;1/04/2015;31/03/2017;;"Over the past 25 years, optical fiber communications have heralded a revolution in the high-speed transmission information of information accros the globe, in perfect synergy with the advent of world-changing concepts such as the world-wide-web, big data transmission and processing, video communication or high-definition on-demand entertainment. The capacity of fiber optic communication systems has experienced a steady growth over the years, adapting to society's requirements. In recent years, worries have arisen regarding the theoretical capacity limits for fiber-optic technology, and several methods have been proposed to overcome the barrier posed by the nonlinear Shannon limit. The ambition of this proposal is to combine several of the most promising (both in terms of potential cost and performance) solutions to this problem, developing new methods for nonlinear effect compensation in systems with advanced optical amplification relying on the most efficient transmission formats. This fellowship is to provide the early career, but experienced researcher Pawel Rosa with an opportunity to expand his experimental knowledge in the field of optical communication and combine techniques from digital signal processing and numerical modelling into the development of novel solutions and patentable methods for nonlinearity compensation in optically amplified optical transmission systems with amplification based on either Erbium-doped fibers (EDFA), advanced distributed Raman schemes or a combination of both (hybrid amplification).
The multidisciplinary aspects of the proposal will benefit the fellow in his way to reaching professional maturity in the field of optical communications and photonics. The project will blend the concepts of advanced optical amplification, coherent transmission, applied mathematics and novel computational methods, under the supervision of world-leading experts in the corresponding areas.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195626;658573;THESUNKIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Thessaly under the Kings: Religion, Society and the Politics of Multiculturalism in Mainland Greece;1/10/2015;30/09/2017;;My project titled 'Thessaly under the Kings: Religion, Society and the Politics of Multiculturalism in Mainland Greece examines the reorganization of sacred space, the cult practices and the religious beliefs attested in Thessaly from the mid-fourth century to the second century BC. The evidence will be discussed in terms of continuity and change, from the gradual modification of the Thessalian geopolitical and urban landscapes, which was exercised by the Macedonian rulers, to the annexation of the region into the Hellenistic Kingdom of Macedonia, down, finally, to the decline of the Macedonian power and the emergence of Roman control in the region.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195505;657751;NITEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NITEC: a Negative Ion Time Expansion Chamber for directional Dark Matter search;4/05/2015;3/05/2017;;The goal of this project is the construction of a Negative Ion Time Projection Chamber (NITPC) with triple Gas Electron Multiplier amplification and pixel readout (GEMPix) for directional Dark Matter (DM) searches. DM is 5 times as prevalent as normal matter in the Universe, but its identity remains unknown. Its mere existence implies that our inventory of the basic building blocks of nature is incomplete: deciphering its nature is one of the most compelling tasks for fundamental physics and astronomy. Weakly Interacting Massive Particles (WIMP) are well motivated DM candidates, independently predicted by Standard Model extensions and Big Bang cosmology. Direct detection experiments aim at observing very low energy (10-100 keV) nuclear recoil of WIMP scattering in the matter. While today leading experiments have managed to reach excellent rejection for electromagnetic components, other background sources (such as neutrinos and environmental radioactivity) will forbid to even think larger mass next-generation detectors without a drastic change in technology. We believe that the combination of the large volumes and improved position and energy resolution provided by the negative ion technique, together with the excellent performances of the GEMPix can offer a significant contribution to this research field. In a NITPC, negative ions drift rather than free electrons, drastically reducing diffusion thanks to their higher mass. This is why we want to combine for the first time this idea with one of the most advanced readout, the GEMPix: a triple GEM detector coupled to a Medipix ASIC board, able to provide excellent spatial, energy and time resolutions. Its sensitivity to single ionization cluster will allow this NITPC, together with the slow motion of the anions, to function effectively as a Time Expansion Chamber, hence NITEC. It's worth noticing how NITEC could work also as neutrinoless double beta decay detector, X-ray polarimeter and microdosimeter for hadrotherapy.;168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ISTITUTO NAZIONALE DI FISICA NUCLEARE;IT;;; 195679;658882;MARIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mixotrophy among small marine phytoflagellates prevalence and impact on prokaryotic communities;1/05/2015;30/04/2017;;"Mixotrophy, i.e. the use of photosynthesis and prey uptake for growth, is increasingly recognized as a major trophic strategy for small ( 20 m) phytoflagellates, which are responsible for a significant fraction of global primary production. In fact, marine primary production in many areas is now thought to be supported by organic P and Fe derived from prey. Despite this, a consistent picture of the overall relevance of bacterivory in open ocean and coastal mixotrophic small phytoflagellates (MSP) is lacking. Additionally, a strict dichotomy between `phytoplankton and `zooplankton is still overwhelmingly employed in models predicting the flow of matter and energy through marine systems, leading to potentially flawed and misleading predictions on ecosystem productivity and the health of global fisheries. This is especially significant when considering that anticipated environmental changes related to climate change are expected to shift the phototrophy/mixotrophy balance, with largely unknown consequences. The present study will combine culture and field work to 1) determine how shifts in environmental conditions related to e.g. season, influence coastal MSP abundance, identity and bacterivorous impact on the whole prokaryotic community, and on specific prokaryotic groups, such as unicellular cyanobacteria; and 2) analyze the importance and basic regulation of bacterial uptake for understudied coastal MSP. The proposed project excellently fuses the expertise areas of the experienced researcher, Dr. Anderson (bacterivory and predator-prey interactions), with the supervisor, Prof. Hansen (mixotrophic phytoflagellates) and the international collaborators, Prof. Jrgens (protist diversity and microbial food web interactions) and Prof. Scanlan (unicellular cyanobacteria), leading to an optimal exchange of knowledge for a successful project outcome. It will additionally restart and further the promising scientific career of Dr. Anderson after her maternity break.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;KOBENHAVNS UNIVERSITET;DK;;; 195553;658116;VesHemiSyn;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exo- endocytosis cycle of individual synaptic vesicles in synapses and hemi-synapses;1/09/2015;31/08/2017;;Neurotransmitters are released by exocytosis of synaptic vesicles at the presynaptic terminal. After exocytosis, vesicular components are retrieved by endocytosis for maintaining efficient synaptic transmission. The mechanism of vesicle fusion and retrieval has been subjected to intense interest but also fierce debate for the last 40 years. Several modes of synaptic vesicle cycling have been described that rely on distinct kinetics, associated proteins and spatial organisation of the exo- and endocytosis sites. Yet, the mechanisms underlying endocytosis initiation and coupling to exocytosis are still largely unknown because the detailed dissection of single vesicle recycling remains a major challenge. Using live imaging techniques and protocols to detect fusion pore opening directly, the fate of vesicle proteins at the plasma membrane will be monitored during synaptic vesicle cycling in synapses and hemi-synapses of cultured hippocampal neurons. I will test the relative contribution of each mode of exo-endocytosis during synaptic activity. Additionally, the favourable geometry of the new hemi-synapse model will allow high resolution mapping of the presynaptic exo- and endocytosis sites. Correlating the organization of exocytosis and endocytosis sites with the location of key proteins such as calcium channels and scaffold proteins will reveal the functional microarchitecture of the presynaptic nerve terminal. Overall, this project will provide new insights into the mechanisms of exo-endocytosis cycle of individual synaptic vesicles.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195576;658256;silvercatpharma;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;from gold to silver: streamlining metal-catalysed cross-coupling reactions;1/04/2015;31/03/2017;;Silvercatpharma project aims at developing C-C cross-coupling reactions catalysed by d11-blocks metals, particularly silver, for the synthesis of pharmaceuticals in Novartis. It strives to have an impact in terms of cost, environment and international visibility because of the use of silver as an alternative catalyst. The project offers me a great opportunity to obtain further training, such as clusters preparation, computational and flow chemistry, and to define my final career in academia or industry because of the possibility of working in these two different environments.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA;ES;;; 195668;658806;LUMIMAGNET-NANO;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multifunctional luminescent and magnetic nanoparticles for advanced biomedical applications;18/05/2015;17/05/2017;;"The key goals of the LUMIMAGNET-NANO project are: (a) the training of a talented young researcher, Dr. Rosa Martn-Rodrguez, in the fast growing field of science, technology and industrial applications of nanomedicine, where the host and partner institutions have a critical knowledge and expertise; and, (b) the design, development and optimisation of cost-efficient magnetic nanoparticles with multifunctional recovering for biomedical applications.

The aim of the research project is to take advantage of both magnetic and optical properties for magnetic hyperthermia applications. The interdisciplinary training program includes preparation of magnetic nanomaterials, surface modification to provide luminescent functionality, characterization, spectroscopic studies including X-ray absorption spectroscopy in synchrotron radiation facilities, in-vitro study, and implementation for hyperthermia applications.

The fellow is a talented researcher who has gained much expertise in synthesis and structural and spectroscopic characterization of luminescent nanomaterials and cell biology protocols during her undergraduate and postgraduate career. To further boost her career, she needs to gain expertise in preparation of biocompatible nanoparticles, magnetic characterization techniques, X-ray absorption spectroscopy and hyperthermia applications, fields in which the University of Basque Country has a world-recognised expertise. Additionally, through two three-month secondments at academic and industrial co-hosts, University of Rome Tre and Resonant Circuits Ltd. respectively, the fellow will gain additional high-level training in X-ray spectroscopy and industrial hyperthermia applications. This multidisciplinary project will also increase her supervision experience, project and intellectual property management expertise, and research funding and proposal writing skills.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA;ES;;; 195664;658764;TMGSiP;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;THz Muti-Gb/s System in Package;1/04/2015;31/03/2017;;"'The goal of 'THz Muti-Gb/s System in Package', i.e., 'TMGSiP' project is to develop a fully integrated 120GHz radio front-end for Multi-Gb/s radio links with state-of-the-art SiGe BiCMOS technology. This will be done with a completely new cross-cutting design methodology for silicon-MMIC, e.g. the development of wideband receiver and transmitter, including on-chip antenna and novel packaging concepts. This will enable a big improvement in the functionality (complexity of RF MMICs), performance (data rate), component size (fully-integrated compact MMIC with integrated antennas), low power, and cost over existing III/V communication systems.
The projects ambition is to realize a THz SiP analog front-end with integrated antennas for a line of sight communication link with data rates up to 40Gbps centered around 120GHz and bandwidth of 20GHz with range up to a few meters. Due to the huge available bandwidth only simple low-order modulation schemes like QPSK will be considered.'";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195803;659510;Experimental Microbiome;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;How mutualism evolves: Experimental microbiome evolution in gnotobiotic flies;1/05/2015;30/04/2017;;"All metazoans harbour considerable numbers of commensal microorganisms in the gut, named microbiota, that contribute to many aspects of normal host physiology. Scientific research has provided invaluable contributions to our understanding of the relationship between host and its microbiota; however, the molecular mechanisms through which the microbiota exerts its beneficial influence are still largely undefined. The metaomics revolution is promoting an explosion of interest in how the gut bacterial community impacts physiology and propensity to disease. In addition, gnotobiotic model organisms provide unique opportunities to study host-microbiota interplay with a level of experimental control that is not achievable in human studies. The coupling of those two approaches should allow to pinpoint key mechanisms underlying this mutually beneficial relationship. This research proposal aims to use those approaches to understand the bacterial genetic pathways mediating host benefits. To this end, we will apply in vivo experimental evolution to mutualistic bacteria, using gnotobiotic animal models. The work will investigate the association between the host model Drosophila melanogaster and one of its most abundant commensal bacteria, Lactobacillus plantarum, which was demonstrated to be beneficial to its host physiology by promoting juvenile growth and maturation.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195649;658846;Rotary Wing CLFC;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Closed-Loop Flow Control to Enhance Aerodynamic and Aeroacoustic Performance of Wind-Turbine Blades;1/05/2015;30/04/2017;;Aerodynamic loads and noise emitted from rotating blades are of interest in many industrial applications, such as wind-turbines, aircraft propellers, helicopter blades, and cooling fans. This research project aims to achieve, for the first time, a combined aerodynamic and aeroacoustic optimization of rotary wing by experiments conducted in a controlled environment of gusting flow and rotating motion. In the current work focus will be made on wind-turbine applications. Both passive and active flow control technologies will be utilized to enhance the amount of energy harvested from the wind, while improving the aeroacoustic properties. Leading- and trailing-edge serration have proven to be effective in reducing the noise emitted from wind-turbine blades. However, their effectiveness under realistic flow conditions in a controlled environment has not been investigated. These experiments will be used for further development and validation of new aerodynamic and aeroacoustic models. The ultimate and final goal is to apply closed-loop flow control by utilizing a physics based model. Alongside these experiments, innovative and stand-alone technology for data acquisition and control in rotating blade environments will be developed and implemented. This holistic interdisciplinary approach, bringing together the aerodynamic and aeroacoustic behaviour of wind-turbine blades under realistic flow conditions into one comprehensive study is unique and novel, and will lead to major advances in our understanding of rotating blades aerodynamics and aeroacoustics.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET BERLIN;DE;;; 195631;658602;COCLIMAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fusion of Alternative Climate Models By Dynamical Synchronization;1/05/2015;30/04/2017;;"Climate models of the sort used by the Intergovernmental Panel on Climate Change (IPCC) all predict global warming over the next century, but differ widely in their detailed predictions for any specific region of the globe. The state of the art is just to run the models separately and form a weighted average of their outputs.
A new approach put forward by the applicant is that of supermodeling: instead of just averaging the outputs of the models, the models are allowed to influence each other in run time. One must specify how much weight a given model gives to corresponding data in each other model. In a supermodel, the weights, or connection coefficients are given by a machine learning algorithm. That is one would use a collection of historical data to train the connections in the supermodel, so that the most reliable dynamical features of each model would be combined. Supermodeling is an instance of chaos synchronization, the phenomenon wherein chaotic systems can be made to follow corresponding trajectories by exchanging surprisingly little information.
In prior investigations with supermodels, it was determined that they are particularly useful for predicting variability, like that in the El Nino cycle in the Pacific. The proposed project would use a supermodel to predict variability in the Atlantic sector due to changes in the Atlantic Meridional Overturning Circulation (AMOC), which has a large effect on climate in the surrounding region on multi-decadal time scales. Existing climate models differ widely in their predictions for AMOC.
The proposed application will require changes in the way supermodels are formed and trained so as to focus on the positions and gross characteristics of coherent structures such as ocean currents. The models that will be used to build the supermodel will be a) a collection of European models, and b) a combination of U.S. and European models from which a supermodel is already being built.";196400,4;196400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITETET I BERGEN;NO;;; 195538;658035;OceanLiNES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ocean Limiting Nutrients Examination from Space;1/05/2015;30/04/2017;;"Marine phytoplankton are the conduit for the flow of energy and carbon into the ocean; consequently they are responsible for the distribution of global fish stocks and regulate climate. Fundamental insights into the productivity of marine phytoplankton can be gained from determining which nutrients are limiting phytoplankton and how these are being altered due to climate change. The approach to investigate nutrient limitation of phytoplankton thus far has been to conduct observations and experiments at sea; however, these activities require substantial investment of resources (ship-time and personnel) and only reveal a snapshot in space and time. A method for making synoptic, low-cost observations using remote sensing would be invaluable. Phytoplankton abundance can be monitored from space using satellite images of ocean colour and a major breakthrough would be to extract a diagnostic signal of phytoplankton stress to monitor patterns of nutrient limitation. Phytoplankton fluorescence signals detected by sensors on satellites carry significant potential for doing this, yet fundamental uncertainties underlying what exactly regulates the signal firstly need to be resolved. Here we propose to perform experiments in targeted regions of the global ocean to address these uncertainties and develop an algorithm to reveal global nutrient limitation patterns of marine phytoplankton using satellite-detected fluorescence. The overarching objectives of the project are to (i) conclusively assess the influence of nutrient limitation other environmental variables on phytoplankton fluorescence characteristics; (ii) implement a correction of the phytoplankton fluorescence signal detected by satellites to reveal global nutrient limitation patterns; and (iii) apply this new understanding of resource limitation patterns in global biogeochemical models to more realistically project the impact of future global environmental change on phytoplankton, fisheries and carbon cycling.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL;DE;;; 195614;658490;CARiPSCTcells;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Generation of safe and efficient, off-the-shelf, chimeric antigen receptor (CAR)-engineered T cells for broad application;1/07/2015;30/06/2017;;The feasibility and effectiveness of adoptive T cell therapies for cancer has now been proven in several clinical settings. Yet, the current approaches are still individual-tailored and thus, their progress and broader use is limited. Having rapid access to off-the-shelf, safe cellular products, which can be applied across histocompatibility limitations, would greatly benefit the broader applicability of adoptive T cell therapy. To this end, the applicant recently reported, in a proof-of-concept study, that genetic engineering of T-cell derived induced pluripotent stem cells (TiPSC) with Chimeric Antigen Receptors (CARs) can be an efficient strategy to concomitantly harness the unlimited availability of induced pluripotent stem cells and direct the specificity and functional potential of TiPSC-derived T cells in an HLA-independent manner. Based on this technology, this proposal aims to further investigate novel stem cell genetic engineering strategies in order to obtain in vitro, unlimited, safe and broadly applicable T cells targeting Multiple Myeloma (MM). We propose to target MM with a novel CD38-targeting CAR (CD38CAR). Since CD38 is not a MM-specific target, we aim to simultaneously tackle the on-target/off-tumor toxicity by introducing a drug-regulated expression of CD38CAR. In addition, we aim to use the CRISPR/Cas9 system to achieve targeted knockout of the endogenous T cell receptor (TCR) and the HLA antigens on the CAR-engineered TiPSCs (CARTiPSC) in order to extend the applicability of CARTiPSC-derived T cells across HLA-barriers. The success of this proposal will lay the foundation for further translational application of CARTiPSC-derived T cells cells and investigation of new strategies to enhance their effector function and persistence.;165598,81;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;STICHTING VUMC;NL;STICHTING VU;NL; 195654;658760;ATCK-HER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cross-cultural heritage. Understanding cultural heritage in a globalized world;1/09/2015;31/08/2017;;"ATCK-HER is a pioneering study of cross-cultural heritage in the context of New Heritage. Traditionally heritage has been defined through artefacts, traditions, and places belonging to one particular nation. In a globalised world, a cross-cultural heritage is emerging: the heritage that is meaningful to people who has been growing up in two or more cultural environments as a direct or indirect result of mobility. ATCK-HER aims a better understanding of the meaning and significance of cross-cultural heritage in today's increasing globalised societies, and to discuss these findings in the context of existing European practices and policies of heritage management. Methodologically, the project will develop a people-centred perspective on heritage, and an innovative empirical participatory methodology in the context of the EU's Faro Convention (2005). The project is innovative both by dealing heritage as a process relevant for citizens today on the uses of identity in the present, and by noticing the active participation of cultural heritage in the major changes that presently take place in the todays globalized societies.
The ATCK-HER project requires the capacity to conduct a completely new field of heritage research both in the academic and the management milieus. Dr Colomer previous experience provides her with the capacities and abilities to take on the project. Moreover, both the research topic and its training-through-research project will catalyze these previous capacities and abilities into an advanced level, allowing to re-establish her academic career into a leadership position in public archaeology in Sweden with an European oriented interest. The mobility proposed to the Linnaeus University will allow her to fulfill this plan since its School of Cultural Studies is an emerging department in the field of public archaeology and New Heritage, willing to welcome future research project leaders.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;LINNEUNIVERSITETET;SE;;; 195490;657681;PULVAD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pressure Unloading LVAD: An Explantable and Cost-Effective Bridge to Recovery in Heart Failure;31/10/2015;30/10/2017;;The ability of the failing human heart to recover after mechanical unloading with left ventricular assist devices (LVADs) has been insufficiently exploited. To fill this void, we engineered the Pressure Unloading LVAD (PULVAD) system, designed to promote myocardial recovery. The overall objective of the proposed translational investigation is to evaluate the feasibility, safety and efficacy of this innovative pressure unloading approach as a bridge to recovery from heart failure. We will first investigate the effects of short-term PULVAD support on systemic hemodynamics and left ventricular mechanoenergetics in a large animal model of acute heart failure. We will then perform a pivotal randomized controlled study to investigate the safety and efficacy of long-term PULVAD support in promoting sustained cardiac recovery in a large animal model of chronic heart failure. If validated, this new technology has the potential to improve quality of life and ease the socioeconomic burden of advanced heart failure. In addition, histological, cellular and molecular analysis of paired myocardial biopsies obtained pre/post-PULVAD unloading will provide insight into mechanisms underlying cardiac reverse remodeling and myocardial recovery.;164653,2;164653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;EL;;; 195789;659425;EMPIREHURIGHTS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Empire and Human Rights: Colonization and Sovereignty in a global Iberian Empire (1580-1640);1/08/2016;31/07/2018;;This project is about human rights in history. The concept and doctrine of human rights as such are a recent creation, only formulated and codified after World War II. The main purpose of this project is to seek early manifestations and perceptions of human rights, in the way they came into existence in the political and juridical culture of early modern Europe. The best way is to take as reference the process of construction of European overseas empires in the sixteenth and seventeenth centuries. Because of its very nature, several issues were inherent to this process that are today considered in the scope of human rights, such as indigenous rights, slavery, religious differences and violence. How did European nations, which were themselves involved in a turmoil of conflicts about their own cultural and religious identity, dealt with these problems? How did governments, decision-makers, theologians, jurists, military, merchants and common people who settled overseas, thought and acted in this regard? And how did the peoples and rulers who watched the arrival of Europeans and suffered the violence of imperial and colonizing processes thought and acted? This research project is mostly focused on the period 1580-1640, when Portugal and Spain became united under the Catholic Monarchy, thus creating an Iberian empire of an almost-global dimension. This allows the analysis of a variety of cultural and geopolitical contexts (Brazil, Mexico, Mina, Sri Lanka, the Persian Gulf, India and the Philippines). It also allows seeking the roots of human rights problems and conceptions outside the frame of reference (Northern and Protestant Europe) that has been mostly considered by this scholarship. On the other hand, by historicizing the concept of human right, we hope to bring some new and different insights to the interdisciplinary approach to this topic, in addition to the perspectives currently offered by international relations, political science and international law.;148635,6;148635,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDADE DE EVORA;PT;;; 195567;658190;ASSEMZYME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Continuous self-assembly using enzyme mediated supramolecular switching;24/03/2015;23/03/2017;;Supramolecular chemistry has resulted in truly sophisticated architectures, many of which are able to exert specific functions, as well as to change and adapt in response to external stimuli. So far, however, artificial structures with a similar functional complexity as living self-assembled systems are lacking. This is because nearly all current supramolecular systems are in thermodynamic equilibrium or kinetically trapped states. Living systems, on the other hand, operate far from equilibrium in so-called dissipative steady states, and continuously consume energy to keep their structure and function. Mimicking nature, here we propose to prepare dissipative self-assembled steady states of synthetic discotic molecules, controlled by competitive enzymatic pathways (phosphorylation / dephosphorylation), in which the supramolecular assemblies are kept far from equilibrium by a continuous perturbation i.e. the influx of a chemical fuel. We expect to get fundamentally new insights into non-equilibrium self-assembly, opening the door to truly adaptive, self-healing, life-like complex artificial systems. The candidate will be trained in a promising new research area in one of the hotspots for supramolecular chemistry in Europe, which would be a great stepping stone for his future independent research career.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE STRASBOURG;FR;;; 195634;658632;ROR2BONE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating Ror2-dependent non-canonical Wnt signaling in bone remodeling;1/05/2015;30/04/2017;;Wnt signaling is composed of the canonical and non-canonical pathways. Canonical Wnt signaling is dependent on ?-catenin activation and has become a major focus for targeting osteoblast-mediated bone formation in the context of treating the debilitating disease osteoporosis. However, much less is known about the role of the non-canonical pathway in bone formation. Unpublished data of the host laboratory demonstrates that targeted deletion of the non-canonical Wnt signaling Receptor tyrosine kinase-like orphan receptor 2 (Ror2) in osteoblasts in mice causes a high bone turnover with increased bone formation and enhanced osteoclast-mediated bone resorption. I thus hypothesize that Ror2 regulates bone remodeling by altering signaling in osteoblasts and their interaction with osteoclasts. In Aim I, I will determine cell autonomous effects of Ror2 on osteoblasts by analyzing cell differentiation, proliferation, survival, and by performing functional studies both in vitro and in vivo. Additionally, since osteoblasts provide pro- and anti-differentiation signals to osteoclasts, Aim I will further explore if Ror2 alters the activity of these signals and investigate the resulting phenotypic changes in osteoclast function. In Aim II, I will undertake an in-depth experimental approach combined with an innovative bioinformatics analysis to investigate the osteoblast-specific non-canonical Wnt signaling cascade downstream of Ror2 after reconstituting Ror2-deficient cells with wild type or Ror2 mutants. Lastly, in Aim III I will directly address the therapeutic potential of Ror2 in several in vivo bone turnover models utilizing a chimeric Ror2-Fc soluble receptor. In summary, I will use state of the art in vivo and in vitro approaches to delineate the downstream Ror2 signaling cascade in osteoblasts and its functional effect on bone remodeling. This fellowship is instrumental in catalyzing career opportunities for me as it provides an ideal environment to reach my full potential.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF;DE;;; 195599;658375;EFTA DEVELOPMENT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The other Europe: the formation and development of the European Free Trade Association (EFTA), 195892;1/01/2016;31/12/2017;;Debates over the type and degree of integration pursued by European states currently dominate the European Union (EU). As the gulf between proponents and critics of the Community method grows more acute, as the EU environment increasingly revolves around interstate relations, and as scenarios of EU disintegration are entertained at various levels, attention has focused on historical precedents of intergovernmental models of cooperation in the hope of foreseeing the EUs future development. Such debates have aroused notable interest in the European Free Trade Association (EFTA), the principal other in postwar European politics. Yet very little is known about how and why EFTA developed in the way it did, its institutional and policy-making structure or the implications of these aspects for the present-day EU. The current state-of-the-art suffers two particular limitations: (i) it concentrates on very short time periods and (ii) it presents a highly state-centric realist account of EFTAs history. This project fills this gap by undertaking a detailed historical study of EFTAs development. It aims to (i) examine EFTAs growth over a sustained period (195892) and (ii) account for this evolution as a product of interplay between actors at the national, transnational and institutional levels. Methodologically, the project deploys an innovative interdisciplinary approach that embeds historical research in the multi-level governance concept borrowed from political science. Empirically, the project draws on EFTAs hitherto underexplored archives in Geneva and the national collections of its various member states. Historiographically, it promises new insights into EFTA history and reconnects the organisations and its members historical narrative to studies of European integration that generally focus more on the denser pre-history of the EU. In so doing, the project adds significantly to both research in the European Research Area and the priorities of Horizon 2020.;179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TURUN YLIOPISTO;FI;;; 195675;658868;MUSIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;How the brain creates Mutual Understanding during Social InteraCtion;31/12/2016;30/12/2019;;How can we understand one another? Our everyday conversations appear to revolve around our linguistic abilities. But creating mutual understanding involves more than formulating grammatically correct sentences. Recently, cognitive science has shown that mutual understanding relies on shared knowledge and beliefs, conceptual knowledge that is continuously adjusted as we interact. Yet, social neuroscience has mainly focused on how individuals respond to social stimuli without a social context. Consequently, the neural mechanism that underlies our ability to create mutual understanding with another person remains largely elusive. The proposed project addresses this interdisciplinary gap, testing the hypothesis that creating mutual understanding requires a neural mechanism that supports a continuous adjustment of conceptual knowledge. That hypothesis will be tested by sampling and interfering with neuronal activity in humans during live social interaction, at the University of California. First, I will investigate the neuronal implementation of mutual understanding through intracranial recordings from the human brain. The exquisite spatiotemporal precision of these recordings offers the unprecedented possibility to characterize how conceptual knowledge is mechanistically adjusted during social interaction. Second, I will investigate frontotemporal dementia, a neurological disorder known to disrupt access to conceptual knowledge. This unfortunate experiment of nature offers the unique opportunity to understand how progressive alteration in brain tissue and connectivity affects the ability to create mutual understanding. These studies will offer a neural- and system-level mechanism of human mutual understanding, which I will translate into testable accounts of communicative alterations in a range of neurological and psychiatric disorders, during the return phase at the Donders Institute and Kings College London.;260929,8;260929,8;H2020-MSCA-IF-2014;MSCA-IF-GF;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 195523;657898;CHLAMYS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Chlamys: The cultural biography of a garment in Hellenistic Egypt;1/05/2015;30/04/2017;;"Hellenistic Egyptian history has been described as a 'tale of two cultures'. This duality is manifest in the differences between the textile cultures of the two ethic groups that came into contact during the time of the Ptolemies. The fundamental differences concern: a/ the traditional fibre used (linen in Egyptwool in Greece); b/ the colour preference for garments (white for Egypt-a variety of vivid colours in Greece; c/ the loom used for weaving (horizontal in Egypt-vertical in Greece). When Alexander the Great first came to Egypt, he decided to leave his mark on the territory, and founded the first city that would bear his name: Alexandria. Descriptions of the city detailed by such later ancient authors as Diodorus Siculus, Strabo, Pliny the Elder and Plutarch report that the city had the shape of a chlamys, the typical woollen cloak of Alexander and his cavalry. The first chlamys-shaped wold map was also produced in Alexandria by Eratosthenes, head librarian at the famous library under the third Ptolemy. The founding of Alexandria inaugurates systematic cross-cultural interactions between Greeks and Egyptians, two ethnic groups with distinct languages, cultures, ways of life, and, naturally, dress. The garment chlamys becomes the garment of Ptolemaic royals, while it continues to be the garment of the army. The make-up of this largely mercenary army, though, had since become ethnically diverse, and included local Egyptians. A host of sources (e.g. papyri, iconography on temples, tombs, ostraca, coinage) testify to the fact that the chlamys becomes widespread in both Alexandria and the rest of the Egyptian territory. This project investigates the garment chlamys both as a material object and as a cultural symbol, thus capturing multiple glimpses of everyday life in Hellenistic Egypt, while providing a reassessment of the ongoing discource on dress, ethnicity and identity in cross-cultural cont";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;KOBENHAVNS UNIVERSITET;DK;;; 195773;659337;NANOFI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanofiber-Trapped Cold Atoms and Applications;1/04/2015;31/03/2017;;An important challenge for quantum information networks is the development of efficient quantum memories and sources of single-photons. A promising category of such devices is based on ensembles of neutral atoms. The motivation comes from the fact that collective effects related to large number of atoms make it much easier in principle to achieve a strong and controllable coupling between the medium and the light. The present project aims at performing such experiments based on an ensemble of cold atoms trapped in the vicinity of a nanofiber, which will enable to obtain a larger optical thickness, a better coupling between collective excitations and light modes and thus a larger efficiency than previous ensemble-based implementations.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;FR;;; 195616;658499;PolAME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Polarimetry of Anomalous Microwave Emission: Implication for B-mode Polarization Detection and Galactic Science;1/01/2016;31/12/2017;;Anomalous Microwave Emission (AME) is potentially polarized in the frequency range [1-100] GHz. The polarization properties of this astrophysical signal have to be characterized and understood completely for one willing to remove Galactic foregrounds in order to detect B-mode polarization for cosmology. The characterization of AME polarization properties is also fundamental in term of Galactic Astrophysics to understand the mechanisms producing the AME. The PolAME project aims to use the QUIJOTE-CMB experiment and its two instruments (the MFI and the TGI) for measuring the degree of polarization of the AME in the domain range [10-30] GHz on a sample of selected sources. This new data, in addition to new C-BASS data and the WMAP and PLANCK maps and ancillary data will be compared to theory and state-of-the-art modelling results. The Galactic science community will greatly benefit the new advances that will be provided by the PolAME project. The main outcome of this project will lead to a stronger characterization of the Galactic Polarized Foregrounds which is fundamental for cosmology. Knew knowledge will be produced about our understanding of the nature of the AME and dust grain evolution processes in our Galaxy.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTO DE ASTROFISICA DE CANARIAS;ES;;; 195652;658769;MYO-DESMOPLASIA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia;1/06/2015;31/05/2017;;In many tumors a desmoplastic reaction takes place during progression, which results in extensive production of collagen by stromal cells of the tumor, mainly fibroblasts and myofibroblasts. Tumor desmoplasia determines in large part the patho-physiology of solid tumors and poses a major barrier to effective drug delivery, affecting the overall survival of cancer patients. Here, the applicant proposes to test the hypothesis that the increase in extracellular matrix (ECM) stiffness and transforming growth factor-beta (TGF?) activation often observed during tumor progression have additive effects on tumor desmoplasia. Therefore, targeting any of these parameters alone or in combination can reduce the desmoplastic response of the stromal cells. To explore this hypothesis, a combination of cutting-edge techniques will be employed. Specifically, a collagen ECM model, with pre-determined topography and tunable stiffness will be developed. Subsequently, fibroblasts and myofibroblasts will be cultured in the ECM models. Cells nano-mechanical behavior and their morphodynamic alterations will be investigated with Atomic Force Microscopy and light/fluorescence microscopy under the presence or absence of TGF? or anti-TGF? agents. Finally, the effects of matrix stiffness along with different TGF? concentrations in the expression pattern of genes encoding ECM components will be investigated using real-time PCR. The research results will elucidate the mechanisms of the interplay between matrix stiffness and TGF? production in modulating the ability of fibroblasts and myofibroblasts to form tumor desmoplasia. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, international and inter-sectoral mobility will reach a position of professional maturity in research.;163648,8;163648,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF CYPRUS;CY;;; 195660;658849;Mycena;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unraveling the ecology of a widespread fungal group by genomic, isotopic and physiological analyses;1/08/2015;31/07/2017;;This proposal aims to shed light on the life strategy of Mycena (or bonnet mushrooms), a widespread group of macrofungi and with important functions in forests and other terrestrial ecosystems. While its members have traditionally been uniformly assumed to be degraders of litter, wood and other dead biological matter, very recent research has suggested that several members could in fact be parasitically or mutualistically biotrophic with plants. In numerous studies, environmental sequences with affinity to Mycena have been observed associated with plant roots. To solve this puzzle, we will use a multifaceted, interdisciplinary approach where we combine traditional knowledge about fungal cultivation with advanced DNA sequencing technology and isotope analyses techniques. The rapidly developing high throughput DNA sequencing technology (HTS) produces millions of DNA strands within hours, and by applying this to plant roots, we will quickly obtain an overview of the presence of Mycena in or on plant roots (indicating a possible biotrophic relationship). We will create a database of Mycena sequences from our own sequencing as well as sequences already publicly available. By sequencing the entire genome of five carefully selected species of Mycena, we will be able to analyse the genomic content associated with different life strategies. As molecular identification of Mycena associated with plant roots does not indicate an ecological interaction per se, we will employ innovative research techniques designed to quantify potential interactions. Isotopic fractionation of carbon/nitrogen of Mycenas and plants at field sites can reveal the mushrooms source of carbon, and co-culturing of biotrophic Mycenas together with plants will provide direct evidence for the nature of their relationship(s). This research will clarify the ecology of a prominent and widespread genus of fungi, thereby illuminating its role in forest and general plant ecology.;208400,4;208400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITETET I OSLO;NO;;; 195552;658110;NORNS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Northern Narratives: The Poetics of Cultural Contact between Germany and Scandinavia in the Middle Ages;1/09/2015;31/08/2017;;"With the conversion to Christianity, literary production in medieval Scandinavia became intertwined with the textual culture of continental Europe. This set in motion a process of interaction that continues to shape and be shaped by the evolution of European identities today. Intellectual responses to the relationship between northern Germany and Scandinavia, in particular, have been defined by rival national perspectives that turn to the medieval period to assert their legitimacy. My project questions this practice by advocating an integrative literary history of the region in the Middle Ages. By applying narrative theory to representative works of romance and historiography in the vernacular from the thirteenth to the fifteenth century, I will reveal the role played by narrative poetics in defining the cultural space around the Baltic. The project will examine the texts as a group for the first time, and thus contribute significantly to changing views of European literary history, in which intertwined regional narratives are replacing the spent force of national ones. Contemporary as it may be, I will show that the origins of this conceptual shift are to be found in a far more distant past.

The project will be hosted by the Centre for Medieval Literature (CML) at the University of Southern Denmark (SDU) in Odense. My motivation is to add a new European relevance to my specialism in Medieval German Studies. This would not be possible to the same degree anywhere else. The Centres location, its rethinking of medieval European literature outside the national philologies, and the expertise of its members are all perfectly suited to enabling a dialogue between German and Scandinavian Studies. I will be supervised by the Centres leader, have direct access to its resources, and be trained in essential skills for my career in academia and engaging with audiences outside it as at the exhibition in the Royal Library in Copenhagen in which the project will culminate.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SYDDANSK UNIVERSITET;DK;;; 195637;658666;REZONABLE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Regeneration and zonation by ZEB2 of Liver Endothelium;1/01/2016;31/12/2017;;"The liver is a crucial organ in metabolism and removal of waste products from the body. Hereto, the liver parenchyma receives a mix of nutrient-rich blood from the portal vein and oxygen-rich blood from the hepatic artery. Blood flows through the sinusoids and leaves the liver via the central and hepatic veins. Hepatic sinusoids are highly specialised channels in which hepatocytes are organised in zones according to their position relative to the portal and central veins. They are lined with a specified, fenestrated, discontinuous endothelium. Many drugs (e.g., chemotherapeutics) and toxins cause damage to the sinusoids that may lead to liver fibrosis and cirrhosis. Formation of new sinusoids is an indispensible step for liver regeneration. Furthermore, liver sinusoidal endothelial cells (LSECs) produce agents that stimulate hepatocyte proliferation. Time-dependent expression of different proteins in the developing liver is important for sinusoid formation. The host lab found that the transcription factor Zeb2 (also known as Sip1) is highly expressed in LSECs in the developing and adult liver. Furthermore, its expression in adult LSECs is mainly in those from the pericentral zone. We hypothesize that Zeb2 is a transcriptional determinant of LSEC specification, zonation, maintenance and regeneration. Here, we aim to: (i) evaluate whether/how Zeb2 contributes to LSEC specification and zonation; (ii) establish a role for Zeb2 in LSECs in adult mice; (iii) assess its role in sinusoidal regeneration during liver disease; and (iv) estimate the therapeutic potential of Zeb2-treated endothelial progenitors in recovery from liver injury. To address these aims, we will use a multidisciplinary approach based on lentiviral overexpression in cultured ECs, transgenic mice lacking or overexpressing Zeb2 in ECs and transplantation of ECs pre-specified towards LSECs. These studies will allow us to evaluate the potential of Zeb2 as a novel target to stimulate liver regeneration.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 195639;658677;MediVAC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bio-sustainable production of natural medicines from Vitex;1/05/2015;30/04/2017;;Vitex agnus-castus (VAC) is a medicinal plant clinically shown to be an effective treatment for premenstrual syndrome. The bioactive constituents are diterpenoids that can interact with G-protein-coupled receptors such as the dopamine D2 and D3 receptors. This specific activity also opens up the possibility of other therapeutic applications where dopaminergic drugs are required, such as for the treatment of Parkinsons disease and other movement disorders. The major barrier to the development of VAC diterpenoid drugs, and the further exploration of pharmacological activity of VAC diterpenoids, is the lack of a source of pure compounds. MediVAC is a 24 month research project that will discover the genes involved in the biosynthesis of pharmacologically active diterpenoids in VAC, and to express these genes in a biotechnological platform for the sustainable production of pure bioactive diterpenoids. State-of-the-art imaging mass spectrometry tools will be used to identify diterpenoid rich tissues which will be targeted for transcriptomics. Then, through the integration of bioinformatic, molecular biology and analytical chemistry techniques, the diterpene synthases and cytochrome P450 enzymes involved in VAC diterpenoid biosynthesis will be identified and functionally characterised. The resulting molecular toolbox of diterpenoid genes will be stably integrated into yeast for the production of bioactive diterpenoids. The engineered host strains hold potential for the future development of an industrial scale production platform able to produce high-purity, bioactive diterpenoids for the pharmaceutical industry. Implementation of this proposal will provide the research fellow with essential training in the field of molecular biology and further her plant metabolic profiling expertise, leaving her with a unique and highly sought after skill set.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195584;658297;POLITICALLIFEWRITING;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;MASS POLITICAL LIFE WRITING;1/09/2015;31/08/2017;;"'Self-narration is extraordinarily common in contemporary culture. The practice constitutes an extremely popular literary genre, is widespread on the internet in the form of diaries updated daily by huge numbers of web users, and is used in organisational training and as a tool in personal therapy education. Employing an interdisciplinary approach drawing on social history, sociology, semiotics and textual analysis my research project will examine one of the 'archaeological' elements underpinning this success: the mass political use of the autobiographical form, first by communism and subsequently by feminism after the Second World War, with a focus on the Italian experience. The Italian Communist Party (PCI) was the largest communist party in the Western world, and Italys experience of feminism is one of the most significant on the European continent. Both movements made intense political use of the autobiographical form. The Italian communists inherited the activist autobiographical framework characteristic of the Bolshevik experience. Self-narration was a prerequisite to joining the PCI until the second half of the fifties; however, this organisational practice became obsolete over the course of the sixties. The link between autobiographical accounts and political activism was subsequently revived by feminism in the seventies, in the context of consciousness raising groups. The main objectives of the project are the following: A) to analyse the mass political use of the autobiographical account in Italy since the Second World War; B) to use this analysis to produce an innovative interpretation of the actual success of self-narration. They will be fulfilled through research in the archives of the PCI and the Italian feminist movement. I will use Italian historical events as a case study to highlight the obscure political origins of a specific activity self-narration that unites various contemporary national cultures of Europe in a transnational manner.'";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195508;657766;BURK-6;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Investigation of the Type VI secretion system-associated toxins of Burkholderia thailandensis;1/09/2015;31/08/2018;;Secretion systems are evolved machineries enabling bacteria to deliver toxins and virulence factors, called effectors, into target cells to enable the onset of infectious diseases. Uncovering these effectors is essential for the understanding of bacterial pathogenesis and the establishment of appropriate therapeutic strategies to tackle infectious diseases. The recently identified Type Six Secretion System (T6SS) is conserved in environmental and pathogenic Gram-negative bacteria. The T6SS is an organelle structurally akin to an intracellular and membrane-bound contractile phage tail used for the delivery of toxins into prokaryotic and eukaryotic target cells. The importance of this system in the context of infection is highlighted by its ability to not only target eukaryotic cells during bacterial infection, but additionally to target other bacteria co-infecting mammalian and plant hosts. Despite the recent advances made in understanding the mechanisms underlying the T6SS dynamic, very little is known about the T6SS effectors repertoire used by life-threatening pathogens, such as Burkholderia pseudomallei, and for which, vaccine strategies are currently unavailable. In the proposed research, a combination of high-throughput and cross-disciplinary technologies will be used to uncover and characterise novel T6SS effectors in B. thailandensis, a surrogate organism closely related to B. pseudomallei. This will 1) identify new T6SS effectors targeting eukaryotic cells, using a reporter-based transposon screening and 2) identify novel T6SS toxins targeting prokaryotic cells, using a genome-wide saturation mutagenesis strategy. The outcomes of the proposed research will identify the key cellular stages hijacked by the T6SS during the infection of a host, while exposing potential new bacterial targets exploitable for the development of novel antimicrobial strategies.;276107,4;276107,4;H2020-MSCA-IF-2014;MSCA-IF-GF;London School of Hygiene and Tropical Medicine;UK;;; 195758;659247;SN-STM_FM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Shot noise scanning probe microscopy: probing the dynamics at the atomic scale;1/04/2015;31/03/2017;;The dynamics of exotic systems such as high-temperature superconductors and heavy fermion materials is gaining ever increasing interest as it contains important clues to the mechanism driving the often unanticipated and technologically very relevant properties. Shot noise spectroscopy is a very powerful technique to study the dynamics of electronic correlations in such quantum electron systems, but to date has been limited to mesoscopic systems. We propose to set up, test and use an experimental probe that can perform shot noise measurements on the atomic scale, thereby gaining access to crucial information on the scale where all the action occurs: the atoms, the electrons, and in combination with spin resolved tunneling spectroscopy the spins. We will achieve this by developing a low temperature, high frequency compatible scanning tunneling microscope. This project will combine expertise on shot noise spectroscopy at CNRS in Paris and low temperature scanning tunneling spectroscopy expertise of the experienced researcher, and will bring important new insights into the time domain properties of correlated electron systems.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195619;658521;EVOREL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolution of Regulatory Landscapes in Chordates;1/01/2016;31/12/2017;;Evolution of animal forms largely depends on changes in developmental gene expression patterns. These genes are controlled by a large number of cis-regulatory elements (CREs) distributed in extended genomic regions organized in 3D chromatin structures known as regulatory landscapes (RLs). However, it is currently unknown how these RLs originate and evolve and how changes in RL architecture and associated CREs have impacted the evolution of gene expression and animal body plans. The aim of this proposal is to understand the evolution and origin of vertebrate regulatory genomic architecture. For that, I will generate an extensive epigenetic and topological profiling of the European amphioxus genome, a slow-evolving basal invertebrate chordate. I will study RLs 3D chromatin architecture, enhancers, promoters, open chromatin and nucleosome positioning through amphioxus embryogenesis using 4C-seq, ChIP-seq, ATAC-seq and RNA-seq and compare these datasets with equivalent results from vertebrates. This will allow me to identify the core RLs organizations that we and other vertebrates share and that underlie the novel and conserved features that characterize our body plan. These results will make ground breaking advances in our understanding of how the regulatory architecture of our genome was assembled during evolution, providing new insights on how RLs organization has impacted gene expression and, ultimately, evolution of animal morphology. By the execution of EVOREL innovative techniques and multi-disciplinary approaches to unveil the deep roots of the human regulatory architecture, I will start a promising research program that will secure my future career as an independent group leader.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195604;658418;PromoTeRapy;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Haploinsufficiency and Intractable Epilepsy Rescue Increasing Endogenous Gene PromoterEfficiency;1/02/2016;31/01/2018;;"This proposal will develop a new tool to rescue haploinsufficiency, which underlies many genetic disorders of neuronal excitability, and provide a new approach to treatment of intractable epilepsy. This new tool is based on the CRISPR-On technology which can regulate the expression of endogenous genes by directly targeting their promoters, which allows expression of the full panoply of splice variants and untranslated regulatory sequences. Importantly, the method does not require integrating exogenous genes into the genome, which has potential risks of insertional mutagenesis. Haploinsufficency of SCN1A, which encodes the sodium channel Nav1.1, leads to Dravet Syndrome, a severe epilepsy. My first aim is to increase SCN1A gene expression in interneurons derived by reprogramming fibroblasts obtained from Dravet Syndrome patients. I will then determine whether this strategy can be effective in non-genetic epilepsies by applying CRISPR-On technology to increase KNCA1(Kv1.1) expression in excitatory neurons in a mouse model of focal epilepsy. This project will combine my previous experience with functional analysis of neurons in different epileptic models; an unparalleled resource of genetically-characterized patients, a well characterized model of intractable epilepsy, and gene therapy techniques at the UCL Institute of Neurology; and expertise on the CRISPR-On method and fibroblast reprogramming of international collaborators.
Epilepsy is one of the most important health burdens within the clinical neurosciences, and finding tools that open new mechanistic and therapeutic insights is a high priority. My proposal exploits an opportunity to establish a new tool to treat epileptic disorders and to create an international multidisciplinary network including neurophysiology, clinical neurology, molecular biology, biophysics and genetics.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195605;658425;Social Jet Lag;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Social Jet Lag: Avian Solutions to Misalignment between Circadian Clocks and Social Cues;1/09/2016;31/08/2018;;"Organisms and their cells exhibit alternating phases of activity and inactivity that are regulated by internal ~24h (circadian) clocks. These clocks synchronize to natural fluctuations in day-light, but also likely respond to other factors including the activity of the social group.

Here, we propose to investigate how individuals cope with misalignment between their circadian clock and social time (social jet lag) a phenomenon studied in only few species (mainly humans and other mammals) and rarely tested in groups of more than two individuals. Specifically, we will investigate how groups achieve collective synchrony when their members have circadian clocks with different periods or entrained to different environmental cues. Multidisciplinary investigations (physiological, behavioural, and ecological) will be conducted on groups of Red Knots (Calidris canutus islandica) - the hosts well established avian model. The project will combine the applicants expertise in collecting and analysing extensive circadian datasets, the hosts experimental set up in the worlds only tidal aviaries, and the partners expertise on an array of circadian clock measurement tools, including a novel molecular method never experimentally applied in birds before.

This unique investigation of social jet lag in a non-human social animal will have three main implications. First, it will test the applicability of a new method to quantify circadian clocks for avian research in general. Second, it will reveal how individuals cope with social jet lag and synchronize to the timing of their group an important topic in the field of time research which, according to the recent foresight study, is one of six fields of key importance for scientific and technological development. Third, it will help us understand whether and how individuals, in a particular social setting, cope with fast environmental changes of the kind increasingly generated by human modification of habitat.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE;NL;;; 195589;658332;WFL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Morphology beyond inflection. Building a wordformation based dictionary for Latin;1/11/2015;31/10/2017;;"The proposed project aims at the compilation of a derivational morphological dictionary of the Latin language, which connects lexical elements on the basis of wordformation rules, through the use of computational linguistic methods.
The final resource will be both a standalone tool accessible through its own website, and interconnected with the Index Thomisticus Treebank (IT-TB), a syntactically annotated corpus of texts of Thomas Aquinas, currently based at the Centro Interdisciplinare di Ricerche per la Computerizzazione dei Segni dellEspressione (CIRCSE), at the Universita Cattolica del Sacro Cuore in Milan.
The integration with the IT-TB will be operated through the embedding of the dictionary data within the morphological layer of annotation of the treebank, using TEI (Text Encoding Initiative) P5 conformant XML encoding which will ensure easy sharing and linking of the data across a variety of potentially related projects, and will make sure, through the use of an internationally recognised standard for the encoding of textual data, such data will be re-usable and expandable in the future.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit Cattolica del Sacro Cuore;IT;;; 195590;658334;OsteoNano;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spatial nanoscale control of growth and adhesion factors to enhance the osteogenic differentiation of mesenchymal stem cells;1/05/2015;30/04/2017;;"In OsteoNano project the training-through-research is targeted at the developing of biomimetic surfaces to study and control the osteogenic differentiation of human Mesenchymal Stem Cells (hMSCs). Osteogenic differentiation of hMSCs can be guided by growth factors, such as bone morphogenetic protein 2 (BMP-2). Currently, recombinantly expressed BMP-2 is applied clinically to enhance the healing of fractured sites. However, the absence of a control over the growth factor surface density and adhesion of cells induce side effects such as ectopic bone formation. The first aim of this project is to present BMP-2 to hMSCs in a spatially controlled manner by applying surface sensitive and high-resolution techniques. The growth factors will be linked to the surface using glycosamminoglycans (GAGs) such as heparan sulphate (HS), and combined with adhesives molecules such as cyclic RGD sequences, which are known to increase the osteogenic effects of BMP-2 by activation of Integrin alphaV-beta3 and alpha5beta1. Our approach will be to design biomimetic surfaces with stepwise increasing complexity, by binding each component in a controlled manner, in terms of orientation, surface density and spatial arrangement. By using these functionalized substrates for hMSCs osteogenic differentiation we will answer several fundamental questions regarding the role of BMP-2 and its interaction with HS and RGD sequences on the osteogenic commitment of hMSCs.
The biomimetic surfaces proposed here, present several fundamental studies, advantages and breakthroughs (i) reduced use of BMP-2 bound on the surface: indeed (i) the binding prevents the cellular internalization of the growth factors; (ii) possibility to enhance the osteogenic differentiation by surface co-presentation of BMPs or/and of RGDs; (iii) surface versatility with respect to stiffness which could positively impact osteogenic differentiation.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195624;658563;FlexCHIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Flexible Complementary Hybrid Integrated Circuits;7/09/2015;6/09/2017;;"The research and development in the field of flexible electronics in recent years has shown that this technology could be a promising key enabler for future consumer applications due to several advantageous characteristics that are absent from any incumbent technology. These include; unique form factor that allows realisation of unconventional electronics such as bendable displays, as well as the inexpensive/high throughput processing that enables realisation of large-area devices such as sensor systems and/or low-cost disposable electronics e.g. medical diagnostics, identification systems. However, the realization of high-performance integrated circuits on flexible substrates for a low-cost/high-volume market still remains very challenging, primarily due to material and process related limitations. The proposed work program follows a unique approach in order to overcome these limitations through the use of solution-processable organic and inorganic semiconductors in combination with optical sintering methods for rapid material processing. The latter will allow the fabrication of hybrid complementary integrated circuits with performance characteristics beyond the current state of the art on arbitrary substrate materials including flexible temperature-sensitive substrates (e.g. plastic) within a fraction of time compared to conventionally used curing methods (e.g. thermal annealing). This multidisciplinary research work opens new insight into hybrid low-temperature additive transistor technologies and promises very valuable original results merging the broad understanding of the novel organic transistor technologies with novel solution-processable inorganic semiconductors in a complementary hybrid transistor integration process which will be beneficial for the further development of low-cost and large-area electronic systems of the future.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195561;658172;PTALLENEST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Platinum-Catalysed Reaction of Bis-Allenes with Nucleophiles: Mechanistic Insights and Future Applications;13/04/2015;12/04/2016;;"For some time allenes were considered simple curiosities because of their apparent unstable nature. However, in the last few years the chemistry of allenes has been extensively developed since they have shown an interesting reactivity and selectivity affording complex structures in an atom economic manner. Bis-allenes have recently appeared as useful building blocks for the synthesis of carbo- and heterocycles. However, their reaction with nucleophiles has barely been studied.
The main objective of this project deals with a recently discovered Pt-catalysed reaction of bis-allenes with oxygen nucleophiles leading to seven membered cycles with a molecule of the nucleophile incorporated in the final skeleton. This new reaction could involve a double coordination of the Pt atom to both allenes, but the mechanism remains unclear. Recent studies in Dr Muozs group suggest that the Pt, in addition to the more common ?2-coordination with the allene, can also appear as a ?1-structure, with the Pt atom coordinated to the central carbon of the allene. The discoveries in this field highlight the importance of acquiring knowledge in the bis-allene coordination, since this information could lead to the preparation of more selective catalyst as well as the isolation of reactive intermediates that can be milestones for the construction of new interesting scaffolds. The present project attempts to shed light into the Pt-bis-allene interaction, to exploit the implications of the coordination modes in the reaction mechanisms, and to apply the gained knowledge to the synthesis of new natural-product like structures with potential biological activity.";91727,4;91727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF EAST ANGLIA;UK;;; 195574;658252;BIOCLIMA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Microbial BIOdiversity CLIMAte feedbacks during environmental crises in semi-enclosed basins: lessons from the Late Miocene (Messinian);1/01/2016;31/12/2017;;"The BIOCLIMA project will explore the impact of climate change on microbial biodiversity in semi-enclosed basins in order to decipher ecosystem response to environmental crises, at a temporal scale much longer than that of human life. The Late Miocene Messinian Salinity Crisis (MSC) will serve as case study. This dramatic paleoceanographic event resulted in the establishment of harsh conditions (eutrophication, hypersalinity and anoxia) at the scale of a whole marine basin, which was lethal for most eukaryotes but allowed some extremophile prokaryotes to flourish.
The BIOCLIMA project will address two main aspects:
1) Tempo and modes of climate variability recorded by MSC sediments. The project will investigate the sedimentary cyclicity recorded by Messinian deposits (carbonates, sulfates, and shales), which was related to climate oscillations at various time scales.
2) The microbial community structures and the modes of adaptation of the microorganisms that inhabited the paleo-Mediterranean at the advent of and during the MSC, allowing to identify the response of microbial life to climate-controlled environmental change.
The project will be based on a multidisciplinary approach, applying cutting-edge sedimentological, geochemical, and geomicrobiological methods. The wider impacts of BIOCLIMA are: i) a contribution to our understanding of the biological adaptation to environmental crises; ii) establishing a catalogue of biosignatures in evaporites that will help to recognize and classify past life in ancient extreme environments on Earth and Mars.
The Fellow will greatly benefit from the training in state-of-the-art methods of Organic Geochemistry and Geomicrobiology in Vienna, and increase his analytical skills in the Petrology and Geochemistry of evaporites during a secondment at the University of Barcelona.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET HAMBURG;DE;UNIVERSITAT WIEN;AT; 195575;658253;QuantuM-nano;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Quantum Measurements with Bose-Einstein condensates strongly coupled to nanophotonic structures;14/08/2015;13/08/2018;;Most of the technologies at the heart of our information society, including the semiconductor and the laser, are based on the laws of quantum mechanics. Yet, there is still a lot to gain in harnessing quantum physics at the elementary level, for example to overcome the sensitivity limits in various kinds of measurements in the quantum regime. In this project, we plan to explore an emerging field of quantum technologies at the boundary between atomic physics and nanoscience, by studying the properties of Bose-Einstein condensates coupled to the evanescent field of nanophotonic structures. We will use this new light-matter interface to build a hybrid quantum gyroscope where the optical Sagnac effect in a photonic integrated circuit is enhanced by slow light in a Bose-Einstein condensate strongly coupled to it. The optical structures will be integrated on atom chips, for improved stability and scalability. Beyond the gyroscope itself, this work will create new prospects for combining the technological opportunities of nanophotonics with the very fruitful field of atomic physics, opening new avenues in quantum technologies, which are expected to become in the near future a key driver for the European competitiveness in information technology.;264668,4;264668,4;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195662;658784;MARCS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A Markedness Account of Romance Clitic Systems;1/01/2016;31/12/2017;;"This project deals with Romance clitic pronouns, i.e. pronominal elements that i) cannot bear primary stress and ii) may have a strong counterpart occurring in a different syntactic position.
The project aims to combine evidence from different empirical domains (historical linguistics, synchronic comparison of present day vernaculars, L1/L2 acquisition, pathology) to elaborate a markedness model accounting for the organization of Romance clitic systems.
First of all, I will try to single out the factors that shape clitic inventories and constrain clitic syntax. These factors can be reduced to abstract parameters, i.e. binary choices with two possible values (positive/negative) dealing with the degree of markedness of syntactic, phonological and morphological structures.
Parameters having a negative value act as filters preventing the occurrence of certain configurations across languages. Languages, however, tend to avoid such configurations by means of different repair strategies (Calabrese 2005), which in turn can be ranked according to a scale of markedness. This hypothesis (namely, a parametric account based on a markedness model with repairs) may provide a better account of the number of variants displayed by grammatical systems w.r.t. cliticization.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;DE;;; 195491;657690;ORC-PLUS;SIGNED;"H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-03-2014;H2020;Organic Rankine Cycle - Prototype Link to Unit Storage;1/05/2015;30/04/2019;;"In line with the call H2020- LCE-03-2014, ORC-PLUS focuses on increasing the technological performance of renewable energy systems, reducing costs and improving dispatchability. The aim is to develop an optimized combination of innovative Thermal Energy Storage-TES (specialized for CSP scale 1-5 MWe) and engineering solutions to improve the number of production hours of an existing small CSP plant, located in a desert area and coupled with an ORC system. With an optimized TES solution, it is possible to extend periods of energy production of a CSP plant (also during non-solar radiation), eliminating or minimizing the need to burn fossil or renewable fuels in hybrid or back-up systems. Nowadays, efforts are being devoted to R&D on TES for large-scale plants, though large potential for small/medium-scale CSP installations exists.
ORC-PLUS is in the spectrum of large scale prototype to pre-commercial scale demonstration. The technology proposed is based on a solar field, using a thermal oil as Heat Transfer Fluid and ORC power unit coupled with an innovative TES. Experimental demonstration of two different industrial prototypes of TES systems will be performed in relevant environment (TRL 6). For each prototype, a simulation model of the pilot processes will be developed, with prototypes of TES systems. The models will be optimized on the basis of the characteristics of the site and power load, to determine conditions and relevant parameters of the real scenarios for each application and to select the TES technology best fitting the needs of the targeted sector. Final result will be an industrial pilot plant used to validate the technology in a real operational environment and to demonstrate its feasibility (TLR7). Validation includes an analysis of the techno-economic viability and environmental impact, and of the replicability of the pilot plant final design. This proposal is supported by three support letters of ESTELA, ANEST and Green Energy Park (Morocco).";7297148,75;6249316,25;H2020-LCE-2014-2;IA;AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE;IT;"EURONOVIA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;ENERRAY SPA;CENTRO DE INVESTIGACION COOPERATIVADE ENERGIAS ALTERNATIVAS FUNDACION;LATERIZI GAMBETTOLA SRL;INSTITUT DE RECHERCHES EN ENERGIE SOLAIRE ET ENERGIES NOUVELLES";"FR;DE;IT;ES;MA"; 195601;658386;AstroSignals;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spatiotemporal dynamics of subcellular energy metabolism in astrocytes;1/04/2015;31/03/2017;;"The functional significance of subcellular compartmentalization in signal transduction has emerged in recent years, a development that is gaining momentum due to significant advances in optical microscopy and genetically encoded biosensors. However, much less attention has been given to the spatial architecture of the metabolic networks that provide energetic support for intracellular processes. This project will investigate spatiotemporal organization of energy metabolism in astrocytes, focusing on two hypotheses:
I propose that within astrocytes, signalling microdomains are energetically supported by local delivery of ATP. I will employ confocal and total internal reflection fluorescence (TIRF) microscopy, using biosensors for ATP, glucose and Ca2\ that can be targeted to subcellular locations. My initial focus is on cultured human astrocytes and the provision of ATP for Ca2\ signalling. Do the five cellular sources of astrocytic ATP support different ATP pools? Which pools are needed for the many ATP-requiring steps that link cell-surface receptors to Ca2\ signals?
I suggest that the ER lumen may provide a glucose reservoir that allows rapid intracellular transfer of glucose to meet local energy needs. The ER of astrocytes contains luminal glucose-6-phosphatase-? (G-6-Pase-?) and a glucose-6-phosphate transporter, which together can generate an ER luminal pool of glucose. The source of glucose-6-phosphate transported into the ER and the function of luminal glucose are unknown. Using cytosolic and ER-targeted glucose sensors, immunocytochemistry and siRNA knockdown of glucose G-6-Pase-?, I will determine the source of the glucose pool and whether it contributes to metabolic support of Ca2\ signals.
Combining state-of-the-art techniques and expertise in the fields of cell signalling and metabolism, this project will enhance our understanding of metabolic regulation of signal transduction, opening new possibilities for targeted treatments of brain diseases.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195622;658556;NanoBragg;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nanofiber-based atomic Bragg structures;1/09/2015;31/08/2017;;In this proposal, we want to create an atomic Bragg structure by carefully adjusting the inter-atomic spacing between nanofiber-trapped atoms to approach a Bragg resonance. The structure allows to engineer the atom-nanofiber coupling for quantum-information applications. We hence build on the recent rapid progress of a novel light-matter interface based on an atomic ensemble trapped in an optical lattice created by the evanescent field of nanofiber-guided light. The small effective area of the evanescently guided light field results in a large optical depth per atom on the few-percent level. The number of atoms can easily reach several thousands for nanofibers with a length of few millimeres. In combination with the proven coherence properties, it is an ideal candidate for the implementation of fundamental building blocks for quantum information processing (QIP), such as efficient fiber-integrated quantum memories for light and optical nonlinearities on the few-photon level. However, in view of recent discoveries related to the coupling between polarization and propagation direction of the nanofiber modes, we believe that the true potential of the nanofiber system can only be unleashed by developing specialized protocols. Those protocols need to take the extraordinary polarization properties of the nanofiber-guided modes and the multilevel structure of the atoms into account. Specialized protocols will benefit from the enhanced coupling of the atoms to the nanofiber provided by the Bragg structure. We will characterize the transmission and reflection properties of the nanofiber-coupled atomic Bragg structure, with special attention to polarization effects. Subsequently we will demonstrate how the Bragg resonance can be used to enhance the spontaneous emission of the atomic array into nanofiber-guides modes with a desired propagation direction and how this significantly improves the success rate of the DLCZ quantum memory protocol.;178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET WIEN;AT;;; 195586;658311;SIBG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Strongly Interacting Bose Gases;20/07/2015;19/07/2017;;"This project addresses questions of emergent phenomena: How do remarkable properties of matter emerge from complex correlations between the atomic constituents? This is one of the current grand challenges in the physical sciences. Specifically, the research will focus on Strongly Interacting Bose Gases (SIBG). The Bose gas is of fundamental significance as a quintessential example of a quantum fluid. SIBG occur when interactions are maximized by a large scattering-length (of a similar magnitude to the interparticle spacing). In the unitary limit (divergent scattering length) all physical properties are expected to scale with the density. Recent experiments with ultra-cold quantum gases have observed that such a state can be created, and its properties accurately measured. Such experiments provide us with access to a remarkably clean and tunable realisation of a strongly interacting quantum many-body system. This is ideal for building up our understanding of many-body physics, which harbours some of the most difficult and relevant questions in the physical sciences. Currently, our theoretical understanding of SIBG is relatively undeveloped, and questions relating to their most basic properties lack consensus. In this project we will theoretically determine the thermodynamics and stability of SIBG. Within this proposal, we outline a set of highly innovative approaches designed to achieve these goals. Our theoretical models are based on an amalgamation of few-body and many-body approaches, for which the combination of; Experienced Researcher Dr Sykes, and LPTMS supervisor Dr Petrov, form a uniquely capable team. This research lies at the cutting-edge of strongly-correlated quantum many-body physics. The results will fundamentally advance our understanding of quantum fluids, and provide us with new theoretical methods/innovations that can be utilised and tested in other areas of condensed-matter and material-science.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195607;658442;MINOTAUR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Metabolic interactions in oceanic photosymbioses;1/01/2016;31/12/2017;;Symbiosis between heterotrophic hosts and microalgae (photosymbiosis) is a widespread and ecologically important phenomenon in the oceanic plankton. Symbiotic organisms like radiolarians (unicellular eukaryotes) are key players in marine biogeochemical cycles by contributing to predation and primary production. While knowledge of the diversity of symbiotic partners has improved in recent years, metabolic interactions remain poorly understood. This project will explore the metabolic basis of planktonic photosymbiosis, with radiolarians as an ecologically relevant model, to understand the functioning of the partnership and its contribution to elemental cycling in the pelagic ecosystem. An original and cutting-edge single-cell approach involving stable isotopes and high-resolution chemical imaging techniques (e.g. ToF-SIMS and nanoSIMS) will be used to visualize the elemental and isotopic composition of intact radiolarian symbioses at the subcellular level, and to quantify the assimilation and transfer of nutrients between partners in different experimental conditions. The same approach will be applied on cultured free-living symbionts to determine the degree of host control over symbiont metabolism. In order to develop a holistic view of metabolic interactions, bioinformatic analyses will identify key metabolic genes and pathways from available transcriptomes of radiolarians. The exceptional microscopy facility and expertise in isotope biogeochemistry at the host institution is unique in Europe. Given the interdisciplinary nature of the project consortium, the potential for exchanging new knowledge and skills is very high. This project pushes back the boundaries of marine biological research and represents a significant step in my personal development towards my long-term research ambition to merge knowledge on biodiversity and physiology into ecological studies to better understand the functioning of aquatic ecosystems and their responses to anthropogenic pressures.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Helmholtz Zentrum fr Umweltforschung GmbH - UFZ;DE;;; 195743;659270;Micro-SOLUTION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Micro-Solid Oxide Fuel Cells based on highly catalytic ceramic oxide thin films nanostructures;1/07/2015;30/06/2017;;Solid Oxide Fuel Cells (SOFCs) are one of the most efficient and fuel flexible power generators. However, a great limitation on their applicability in portable devices arises from long start up times involving high energy consumption. A recent revolution based on the integration of SOFCs in mainstream silicon technology allows overcoming these drawbacks while opening new avenues for the use of fuel cells as uninterrupted power generators in mobile applications such as consumer electronics. Starting from the most recent breakthroughs of the hosting group, the Micro-SOLUTION project will be focused on improving the performance of SOFCs at high temperatures (700 C) by developing thin film full-ceramic electrode materials with high catalytic activity. To achieve this goal, surface decoration of highly stable thin film nanostructured electrodes will be carried out. Further integration of the optimized electrodes in ?SOFC cells will bring power densities above 500mW/cm2. The inter/multidisciplinary approach proposed in the Micro-SOLUTION project will allow the researcher acquiring new skills in Key Enabling Technologies such as nano- and micro-technology. Moreover, two different secondments in the Institute of Microelectronics of Barcelona and the company FAE will complement the researchers training giving him a multisectoral point of view and a clear idea of transfer knowledge activities in the field of Solid Oxide Fuel Cells. Therefore, planned research and training activities in the Micro-SOLUTION project will re-enforce a position of professional maturity in research and will provide the researcher new career perspectives.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE RECERCA DE L'ENERGIA DE CATALUNYA;ES;;; 195645;658714;PALECOEVOL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Paleo-ecogenomics in Daphnia: developing a model for studying evolutionary impacts of climate and environmental change;1/06/2015;31/05/2017;;PALECOEVOL is a highly multidisciplinary study combining population genomics with paleoecology, and is firmly embedded in the theoretical framework of evolutionary ecology. This transformative research is based on the direct observation of evolution in the past 2000 years in the highly endangered Arctic environment. By recording population genomic parameters before and after environmental shifts, a pioneering dataset unprecedented in genomic detail will be supplied and rigorously combined with historic environmental data. The overarching goal is to study, across millennia, the genomic responses of the ecological and genomic model organism Daphnia, an aquatic keystone herbivore, to repeated shifts in temperature and related environmental parameters, and to lay the foundation for establishing a novel model system to study the effects of environmental change at the population level. This and future work will transform our current understanding of the magnitude and the constraints of population adaptation to the rapid environmental changes our planet is now facing. The overall impact of this fellowship results from cross-fertilizing the gained ecological and genomic expertise with training the prospective fellow in its application towards environmental regulation and policymaking that will qualify her to provide leadership for academics and legislators alike.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195571;658227;SOCUPols;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Supported organocatalysts and their applications in the upgrade of bioderived polyols: desymmetrisation of glycerol to obtain building blocks for fine and pharmaceutical chemicals prod;1/02/2016;31/01/2018;;"Cooperative nucleophilic-electrophilic catalysis by ionic liquids (IL) has been recognised as a powerful tool for sustainable chemical transformations. Some of these transformations proved to be suitable for biomass derived chemicals upgrade. The SOCUPols project aims at preparing novel organo-catalysts based on supported IL-like fragments for the upgrading of biomass derived polyols such as diols and glycerol. Unlike ionic liquids and other organic salts, these heterogeneous catalytic systems will be fully recyclable and suitable for continuous flow operation. Project development will focus on the overall process sustainability: (a) by developing new polymer supported catalysts for environmentally friendly transformations; (b) by using these catalysts for the selective chemical upgrading of diols and glycerol (transesterification/acetalisation reactions) using green solvents and reactants; (c) by using carbonate formation as a CO2 fixation strategy; (d) by modifying the catalytically active sites to carry out asymmetric transformations, thus achieving the desymmetrisation of glycerol towards chiral synthons for fine and pharmaceutical chemistry; (e) implementing the most promising transformations in continuous flow (CF).
This approach will be used for the design of simple and feasible strategies for the exploitation of renewable biogenic resources by retaining molecular complexity of biomass-derived material to prepare added value molecules and materials. This will represent a better alternative to low oxygen containing petroleum-derived feedstocks.
Through SOCUPols, Dr. Marco No, Experienced Researcher (ER) interested in sustainable chemistry and fine and pharmaceutical chemical synthesis, will pursue academic career development through a specific technical training and project managing expertise, integrated with complementary added-value non-scientific skills.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA;ES;;; 195783;659398;ACE_GFAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of retrieval techniques for aerosol microphysical characterization from multi-wavelength space-borne lidar and radiometric measurements;1/02/2016;31/01/2018;;This work focuses in establishing a collaboration between NASA and the Atmospheric Physics Group of the University of Granada (GFAT) in the framework of the upcoming Aerosol-Cloud-Ecosystems (ACE) mission. Such collaboration will create a good environment for the progress in the atmospheric sciences and advance our knowledge of the Earth-Atmosphere radiative system. The research activity focuses on performing lidar ACE simulations studies that includes defining the optimum capabilities of such system in order to obtain aerosol microphysical properties under the accuracy and errors claimed in ACE white paper. The techniques to be used are regularization and Linear Estimation (LE), and special emphasis will be paid to the retrieval of coarse particles predominance. In this context GFAT offers a unique environment thanks to the possibility of evaluating these techniques by MW ground-based lidar and to its large set of in-situ and radiometric instrumentation. The advances in LE will be used to perform high temporal-resolution of fine and coarse mode of columnar aerosol properties using measurements of aerosol optical depth (AOD) by AERONET sun-photometers. This will be done combined with the Spectral Deconvolution Algorithm (SDA\). Finally, as GFAT operates one of the few star-photometers in the world, we will evaluate the potentiality of improving lidar retrievals using AOD from star-photometry. In this context, a secondment with the Laboratory of Atmospheric Optics at the University of Lille (LOA) is planned to extend night-time retrievals of the GARRLiC algorithm, and thus obtain vertical profiles of particle volume through an easy deployment of backscatter elastic lidar and star-photometry.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSIDAD DE GRANADA;ES;;; 195630;658596;Constructions;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Construction Grammar meets Typology: From Theory to Teaching;1/09/2016;31/08/2018;;The worlds languages differ in how they conceptualize events central to the human experience, such as motion and change of state, by means of constructions. This project investigates the expression of these meanings in four major European languages, English, German, Polish and Spanish. The aim is (i) to identify, through a fine-grained study of corpus data, the language-internal factors (semantic, morpho-syntactic, etc.) underlying cross-linguistic variation, including differences that can be observed in languages considered to be typologically related and (ii) to implement the findings in foreign language acquisition by developing a comprehensive pedagogical grammar of constructions. Consistently, this proposal involves three main phases. The first one consists of data collection and description. The second one is dedicated to data interpretation in the light of the theories concerned with verbal constructions and typological variation, namely Construction Grammar (Goldberg 1995) and Talmys (2000) typology of macro-events. In particular, it will be claimed that the typology of languages, as proposed by Talmy (2000), is in fact an epiphenomenon of a typology of constructions whose distribution in the worlds languages is constrained, among others, by the availability of grammatical devices, such as verb prefixes, verb particles, prepositions, etc. The third phase proceeds with translating the theoretical results into a user-friendly multi-lingual grammar of constructions, which permits to elucidate certain high-level morpho-syntactic generalizations, invisible in the prevailing verb-centred teaching materials. Therefore, the findings of this investigation would be an innovative contribution both to the theoretical debate on linguistic diversity and to the cross-linguistic communication in a broad sense, which seems to be especially relevant in the modern world characterized by close relationships between languages and cultures.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195728;659144;SCEL-TA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Surfactant controlled Cation Exchange Lithography - Towards Application;1/09/2015;31/08/2017;;"A novel lithography technique, the Surfactant-controlled Cation Exchange Lithography (SCEL) will be explored. The underlying mechanism, the Cation Exchange (CE), stems from the colloidal synthesis of nanocrystals (NCs). It allows for the transformation of the chemical composition of readily prepared NCs by exchanging their cation sublattice without changing their morphology.

The SCEL relies on the selective inhibition of the CE in NCs that have been exposed to a high-energy radiation, e.g. in an e-beam lithography step or by UV-light. It has been shown that the radiation induces a cross-linking of the surfactants, which then, when exposed to a solution of suitable cations, form an impermeable shell for the cations and thus inhibit the reaction.
In the proposed SCEL the cation exchange will be carried out on thin films of NCs (mostly CdS or CdSe), which are then partially transformed into CuXS or CuXSe, respectively.

We will investigate on the limits of the SCEL as a competitive lithography method in terms for the production of devices with colloidal nanocrystals as functional elements. Ideally, we will be able to controllably address a small number of NCs by transforming their neighbours into conductive material. The research comprises a study on the mechanism of inhibition of the cation exchange after irradiation and a study on the dynamics of the CE in individual nanocrystals.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;IT;;; 195559;658162;HORIP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Higher-Order Rewriting for Intensional Properties of Programs and Circuits;1/10/2015;30/09/2017;;"'The HORIP project will employ higher-order term rewriting to characterise intensional program properties: properties concerned with 'how' rather than 'what' a program computes, such as complexity, compressibility and safety.

Term rewriting is a formal system which can be used to specify algorithms. Unlike common programming languages, term rewriting has a simple, formal definition which admits non-determinism. Higher-order term rewriting is an extension therof, which shares these advantages but has greater expressivity.

To analyse program properties, we may either use dedicated techniques, or translate queries into different fields, with term rewriting as a powerful option. In doing so, methods from widely different areas can be applied.

HORIP aims to analyse intensional properties using higher-order term rewriting. The first phase will attack two lines of research ripe for success: implicit complexity and compiler correctness. For the former, the supervisor is an expert in complexity and the fellow in higher-order term rewriting. For the latter, we will work together with industry collaborator Dr. Rose, who develops the CRSX framework which seeks to describe compilers using a special form of higher-order term rewriting. Leveraging the expertise of all three parties and potential local collaborators, strong results are expected, especially since the higher-order setting avoids many intrinsic limitations of previous work. In the second phase, we extend these ideas to complexity and compressibility of logical circuits. This builds on the first year's experience with implicit complexity, and the expertise of the scientist-in-charge.

HORIP is basic research, building on very recent advances from several international research groups. There are potential future business applications, as well as also purely theoretical goals. All results and related code will be published open source, so as to aid both basic and applied followup research.
'";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195713;659067;MAPS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Millimeter Wave Massive Arrays enabling RFID/Radar Applications on 5G Smartphones;20/07/2015;19/01/2017;;"Nowadays, a rising interest is moving towards the fifth generation (5G) of wireless mobile communication, as numerous devices and different heterogeneous networks will be interconnected, guaranteeing zero-distance connectivity between people, devices and objects. To deal with the ever increasing data traffic demand and the low power consumption requirements in the perspective of a sustainable growth, smart solutions have to provide energy- and cost-efficient services. In this context, the massive antenna arrays deployment in base stations, access points or smartphones, appears like a viable solution to meet these new challenges. Besides communication, the availability of such a technology can also allow other interesting applications such as accurate simultaneous localization and mapping (SLAM) performed by a personal radar integrated in smartphones, enabling new services in the device-to-device communication. In addition, the interrogation of tagged objects placed in the environment through radiofrequency identification (RFID) technology will allow a mapping of the real world into the internet space, enabling environment-related applications and constitute the so called smart space within the Internet of Things concept. Moreover, the reduced wavelength at millimeter-waves (mmW) paves the way for packing a large number of antenna elements into a small area, overcoming the difficult integration of laser-based or mechanical steering devices into mobiles.
In this context, the project addresses in a unified framework the problem of achieving environment 3D mapping and objects identification by means of massive antenna arrays embedded on smartphones, which have the capability to learn from the environment and consequently continuously improving their performance. An offline-demo, exploiting real measured data performed during the project, will be realized in order to show the main achievements and performance guaranteed by the proposed system.";129807;129807;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;;; 195615;658494;ENEFOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Forecasting oil prices, oil price volatility and economic policy uncertainty;6/04/2015;5/04/2017;;Oil price and oil price volatility forecasts are of major importance, given the oil market is well crowded by participants who proceed to decisions based on these forecasts (e.g. oil traders, monetary policy authorities, etc). The current state-of-the-art forecasting techniques, though, (i) involve a trade-off among internal consistency, forecasting accuracy and easiness to communicate aspects and (ii) do not use ultra high frequency data. Thus, this exciting and innovative project aims to develop new econometric model frameworks to forecast oil price and oil price volatility, which will be successful in enhancing internal consistency, forecasting accuracy and easiness to communicate extracting added-value (in terms of predictability) information from the ultra high sampling frequency. In addition, this project aims to use the forecasted oil price volatility to predict the economic policy uncertainty in Europe, given that oil price shocks exert significant impact on the effectiveness of economic policy. This project will allow the researcher to advance his existing scientific and transferable skills through the cutting-edge training in the state-of-the-art forecasting techniques, as well as, in programming, consultancy and policy formulation skills. The outcome of this training (i) will provide the fellow with an invaluable opportunity for the development of a pioneering research agenda and (ii) will position him as an internationally recognised scholar that contributes to research excellence in Europe. The established capacity of the fellow as an independent researcher in the area of energy economics, the expertise of the scientist-in-charge in state-of-the-art forecasting techniques and the infrastructure of the host organisation offer great complementarities, which will allow these highly innovative model frameworks to be realised. This project will have a great impact not only to the researcher, but also to the host organisation and to the European Research Area;164653,2;164653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;PANTEIO PANEPISTIMIO KOINONIKON KAIPOLITIKON EPISTIMON;EL;;; 195611;658478;MSMART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Margination of Microcapsules in Small Arteries;3/09/2015;2/09/2017;;Intravascular delivery of microcapsules is emerging as a novel and effective approach in targeted therapeutic and diagnostic procedures in cancer and cardiovascular diseases. It encapsulates drugs or imaging-contrast agents and functionalizes the surface of the capsule to target specific diseased sites. However, a major challenge in its applications is to improve the adhesion efficiency of capsules to the endothelium (a monolayer of cells that lines the luminal surface of blood vessels) under complex blood flow conditions. While extensive research has focused on identifying disease-associated biomolecules on the endothelium, or suitable antibody/peptides targeting these molecules, much less attention has been given to the margination of the drug carriers from the blood stream to the vascular wall, especially in arteries where many diseases develop. Margination represents the crucial first step before adhesion. The aim of this project is therefore to investigate the cross-sectional migration of microcapsules in arterial blood flows and to develop scientific understanding of how the size, shape and deformability of capsules, as well as system parameters such as the blood haematocrit, blood flow inertia and pulsatility, and vessel geometry affect the margination of the microcapsules. The project will unit the state-of-the-art in-vitro, ex-vivo experimentation and numerical modeling resolving blood flow at a cellular level. A second aim of the project is to develop practical principles for designing microcapsules with optimum margination property in arteries. The project will pave the way for novel designs of injectable medicines or imaging-contrast agents with enhanced vascular targeting efficiency.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195560;658170;breast cancer dormancy;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular characterisation of a clinical model of estrogen receptor-positive breast cancer dormancy;1/09/2015;31/08/2017;;'Endocrine therapy has clearly improved outcomes for estrogen receptor alpha positive (ER\) breast cancer patients, however the cumulative incidence of recurrence and death continues at a steady rate. The majority of ER\ breast tumours treated with neoadjuvant letrozole in respond quickly and are generally excised after three months. A minority of tumours maintain a stable size by becoming dormant, these tumours continue to receive extended letrozole treatment and therefore represent the best currently available clinical model to investigate dormancy. We have previously performed a number of dynamic molecular studies of cancer treatment by taking pre- and post-treatment tumour biopsies utilising the 'window of opportunity'. In this study, for the first time, the dormant cancer cells from breast tumour biopsies that have received extended (1-3 years) neoadjuvant endocrine therapy will be studied. This study aims to characterise the ER\ breast cancer dormancy and letrozole resistance using expression profiling technologies of this unique series of breast tumour biopsies. The genome- and proteome-wide expression data will be analysed and compared with data for the same patients at diagnosis, at two weeks and at three months following treatment and with the clinical outcomes. Our study will be the first to characterise extended growth suppression in letrozole-treated dormant-state breast cancer. This knowledge will be very valuable to extend ER\ breast cancer patients' survival and quality of life by preventing metastasis and also contribute to the economy and society by introducing a individualized therapy that is tailored in accordance with cancer patients expression profiles. This multidisciplinary project combines both clinical and academic aspects along with exposure to the non-academic sector, in order to provide the fellow with great competence in cancer genomics through training in advanced integrative bioinformatics analysis of high-throughput data.';195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195478;657615;NanoLight;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Photophysics and photochemistry of light harvesting complexes in the vicinity of optical antennas;1/09/2015;31/08/2017;;"The general objective of the project is to understand the photophysical processes in light harvesting complexes in the vicinity of optical antennas and particularly, the impact of quantum coherence on efficiency and directionality of ultrafast energy transport in photosynthesis.
Purple bacteria is an organism that most effectively transforms solar energy into chemical one. Light harvesting complex 2 (LH2), plays key role in this process: collects solar energy and transfer it to the reaction centre. The photophysics of light harvesting complexes is still not fully understood. In recent years long-lived coherences were observed, which was unexpected for such complicated systems. Many crucial questions appeared: Are the coherences purely induced by excitation schemes? Do they have a biological function? Is the nature of the coherences electronic or vibrational? So far, the experimental approach concentrated on ensembles, but the complexity of the system cause that registered coherences are temporarily and spatially averaged, which makes it difficult to answer the questions. One can lift the ensemble by observation of one-by-one individual LH2 complex with single molecule (SM) spectroscopy methods.
The observation of SM fluorescence requires chromophores with high quantum efficiency. Unfortunately, LH2 QE is very low. To enhance the fluorescence signal I propose to use optical antennas. These nanoscale structures, can focus electromagnetic energy to a spot of nanometric size. If the molecule is placed on such spot, the strong interaction between antenna and molecule allows the registration of enhanced SM fluorescence and even Raman spectra. With that tool, the study of LH2 complex at the SM level is possible. Hence we propose the investigation of single LH2 complex coupled to the optical antenna with ultrafast fluorescence and Raman spectroscopy, two complementary methods providing information about both, ground and excited state evolution.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 195475;657599;HOTSPOT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Accessing hot-spots in plasmonic nanoantennas;1/05/2015;30/04/2017;;Guiding molecules/nanomaterials to the right place in plasmonic nanoantennas is a key problem to be solved in order to benefit from the high electromagnetic field localization offered by these materials. Accessing these nanoscale-regions remains a significant challenge in plasmonics and is the main goal of this project. The novel approach introduced here is based on the field-enhancement properties of the nanoantennas, thus spatially selective to the hot-spots. This easy, fast and cheap strategy can allow selective and large-scale positioning of any kind of molecules and/or nanomaterials in a variety of plasmonic-nanoantenna hot-spots, independently of their shape and resonance position. This strategy can solve the big challenge of hot-spot modification in plasmonic nanoantennas thus opening new doors to many real applications ranging from biosensing to energy conversion.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195592;658349;PINC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards p-type conductivity in In0.5Ga0.5N nanocolumns on a Si (100) substrate with GaN buffer layers;15/06/2015;14/06/2017;;We propose a 24-months-project, working on the growth and characterization of Mg doped InxGa1-xN Nanocolumns (NCs) on a Si (100) substrate with a GaN buffer layer, aiming to achieve the p-type conductivity in In0.5Ga0.5N NCs. In the previous study, selective area growth (SAG) of In(Ga)N NCs on top of a GaN buffered Si substrate by using plasma-assisted molecular beam epitaxy (PAMBE) has been achieved. Subsequently, the major challenges for fabricating p-In0.5Ga0.5N/n-In0.5Ga0.5N/p-Si/n-Si stacking solar cells deal with the achievement of controllable p-type conductivity in In0.5Ga0.5N NCs and its reliable assessment. Ordered Mg-doped InxGa1-xN NCs will be grown on a Si (100) substrate with a GaN buffer layer by using PAMBE. The growth will start with Mg-doped In0.3Ga0.7N/GaN NCs. Then Indium mole fraction in subsequent samples will be increased gradually, approaching 0.5. During the process, different characterization measurements will be performed in order to optimize the growth conditions.The proposed project will provide high quality p-type InxGa1-xN, 0.3x0.5, NCs on a Si (100) substrate with a GaN buffer layer for further processing. The electronic and structural properties of Mg-doped InxGa1-xN, 0.3x0.5, can be abstracted from the characterization results in the project. The information will fill the research gap in the Mg-doped InxGa1-xN, 0.3x0.5.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD POLITECNICA DE MADRID;ES;;; 195556;658133;FUTURESYRIA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mapping an uncertain future: Social and spatial change in conflicting Syria;1/09/2015;31/08/2017;;"This research project in Human Geography aims at understanding the spatial and social dynamics of the Syrian conflict (from 2011 onwards). It focuses particularly on the local dimension of both the dynamics of the uprising, the political mobilisations, and the militarisation of the conflict, as well as on the different types of local networks and local organisations and forms of governance that developed since. Looking at the dynamics of the current crisis from the ground helps indeed our understanding of the current spatial and social reorganisations.
The territorial fragmentation experienced nowadays in Syria, which is in part an effect of the logics of the repression and warfare tactics of the Asad regime, bears profound and long-term effects on the Syrian society. In addition, in 2014, nearly half of the Syrian population is displaced, having either taking shelter outside Syria (refugees, registered or not) or in Syria (Internally Displaced Persons). The scope of destruction is high, questioning the ways in which people can return, if ever, one day. Therefore, Syria faces massive changes both in its social and its territorial fabrics, in the short-term as well as in the foreseen future. Structural changes and challenges may affect its the neighbouring countries too.
The objective of this research programme is to explore the territorial and social changes that occurred in Syria since 2011, based on local contexts and focusing on local situations: the interrelated movements of people (IDPs and refugees), logics and impacts of destructions, and local dynamics of warfare. This research, based on the collection of local data (through interviews with people inside Syria (through skype) and refugees outside, information collected through social networks, or open data newspaper, reports from NGOs, International agencies, satellite images), will also lead to the production of original maps, at different scales.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195600;658376;ERIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Europe's Reception of the Irish Melodies and National Airs: Thomas Moore in Europe;1/09/2015;31/08/2017;;"'ERIN offers a network analysis, investigating the cultural articulation of national identity in 19th-century Europe as found in the musical works of Irish poet-songwriter Thomas Moore. He created two European song series, the Irish Melodies and National Airs, of global circulation; these inspired arrangements by European composers. His epic poem Lalla Rookh inspired operas and ballets. ERIN is the first systematic study of this cultural network, and innovative in considering the temporal and spatial aspects of networking. ERIN contributes to the knowledge-based economy and society through accessible research outputs designed to engage the European public: an online forum, a podcast, a radio show, an interactive online exhibit, a database, an edited book. ERIN's research foundation is the substantial Moore collection at host Queen's; a database of its and other's Moore holdings becomes a dataset to be mined for the remaining outputs. The researcher will establish a network between herself, Queen's and selected European libraries in the process of preparing the database and the online exhibition. The researcher acquires skills that enhance her intersectoral mobility within Europe by observing a carefully-chosen training programme at Queen's that will also benefit ERIN's project outcomes. This training will also prepare her for an intended media secondment. By leading ERIN, the researcher will gain project management skills and gain valuable intersectoral contacts. Through leadership, networking, and training, the researcher will be involved in knowledge transfer. She will build on her existing experience as a contributor to several significant bibliographical and historiographical projects; the MSC fellowship will enable her to assume a position of leadership in the scholarly community (or in the media) while enhancing her creativity. Queen's enjoys 'HR Excellence in Research Status' and offers the researcher a stimulating interdisciplinary research environment.'";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE QUEEN'S UNIVERSITY OF BELFAST;UK;;; 195463;657522;NEW URBAN UNIVERSITY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Situating the New Urban University: Higher Education in an Era of Global Urbanization;1/10/2015;30/09/2017;;"The global impact of urbanization presents unprecedented opportunities and profound challenges for universities. It significantly impacts the expectations placed on universities and where in the world and the city they need to adapt their institutional infrastructures, pedagogical practices and ways of operating. The multiscalar networks of global urbanization mean urban universities must be understood as being more than simply located in the city. The new urban university is regionalizing and globalizing in dramatic, chaotic ways. What capacities do universities have as urban leaders in a globalizing world? How can universities better mobilize in, and for, extended city-regions? How can marginalized urban communities inform universities spatial and strategic actions? Situating the New Urban University responds to the challenges of global urbanization by illustrating how higher education providers can better serve people in places, versus drawing people to a place. By taking stock of the influence major sociospatial changes in urban regions have on universities (e.g. globalization, neoliberalization), the project: (1) provides an international assessment of universities engagement practices and impacts; and (2) presents a major comparative examination of higher education systems at the city-regional scale. In-depth studies of universities spatial strategies in the London and New York global city-regions will speak directly to best practices in creating and sustaining reflexive, resilient university-society networks for diverse communities in urban contexts. Stakeholder involvement from the initial phases of the research allows the project to integrate direct input from in the research design and outputs. Situating the New Urban University deepens academic and policy understandings of how knowledge transfer takes place in global city-regions, enabling higher education and urban policymakers to optimize universities contributions and societal impact.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195596;658360;NANOSPHERE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NANOStructure Photochemistry via Hot Electron driven REactions;15/03/2015;14/03/2017;;"The current research proposal aims utilise the unique macrocyclic host guest chemistry of cucurbiturils in conjunction with metal nanoparticles to demonstrate a novel and malleable approach to nanoparticle self-assembly, resulting in structures that will be used in light driven chemical reactions and advanced molecular sensing. This represents an important area of research, for whilst nanoparticles and assembled nanostructures show promise in a wide variety of applications, their uptake into current technologies has stalled due to the difficulty of their production, post-assembly manipulation and chemical loading. This project will demonstrate a new paradigm of functionality and versatility in nanoarchitectures. This will be achieved by assembling nanoparticle structures with a unique group of rigid macrocycle assembly agents, cucurbiturils. Cucurbiturils, with their versatile host-guest complexation chemistry, will allow for post assembly control of nanostructures via multiple external stimuli, while also giving flexibility in terms of application, with many kinds of molecules able to be loaded into the inner cavity of the cucurbiturils, yielding chemical sensing and reactor constructs on the nanoscale.
Fundamental insights will be gained into the assembly and manipulation of nanoparticle superstructures, with an eye for application. To this end, Dr. Steven Barrow, the applicant, will work with Dr. Oren Scherman, in collaboration with Prof. Jeremy Baumberg. This linkage represents a unique opportunity to explore nanoscale systems at the University of Cambridge. This project will be highly supported in both the Chemistry department with Dr. Scherman, as well as the Physics department with Prof. Baumberg, at the University of Cambridge. The University of Cambridge is world renowned for its high impact research in the fields of chemistry and physics and this project represents a unique opportunity for collaboration between the two departments.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195581;658270;WO for solar fuels;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Integrating molecular water oxidation catalysts with semiconductors for solar fuels generation;1/05/2015;30/04/2017;;One of the biggest challenges of our society is the need to find a renewable, clean, easily storable and transportable energy source. Hydrogen and other solar fuels (e.g. methanol or formaldehyde) have been appointed as one of the future energy vectors. Having natural photosynthesis as inspiration, we can develop a device capable to split water using sunlight, obtaining oxygen and hydrogen. Although rapid progress is being made in the preparation of nanostructured electrodes that use visible light for fuel synthesis (including H2 evolution and CO2 reduction), their efficiency still remains modest due to slow catalytic function, the multi-electron requirements and the loss in efficiency due to electron (e-)/hole (h\) recombination. We aim to address these limitations by functionalising semiconductors with molecular catalysts for water oxidation, designed to achieve unidirectional charge separation and capable of accumulating multiple oxidations. This project involves the complete characterisation of the electron processes taking place within the photoanode using time resolved spectroscopic and electrochemical techniques. Through iterative design-evaluation-feedback we aim to identify the key limiting factors and model general rules to enhance the performance of photoanodes. Ultimately, the photoanodes will be assembled with a functional cathode to build a complete photoelectrochemical cell for solar fuel generation.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195460;657512;ECECWorkforce;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Knowledge, Skills and Attitudinal Competences for Quality Early childhood Education and Care;1/09/2015;28/02/2017;;The education and training of the Early Childhood Education and Care (ECEC) workforce is of prime importance as it equips practitioners with the knowledge, skills and attitudinal competences needed to work with children. Training supports them in creating quality environments for children to enhance the quality of provision and subsequent child outcomes. The research is timely with the increased interest in the benefits of quality ECEC for supporting the holistic development of children, but with a need to understand more about the role of the workforce in this. Whilst qualifications have been established as important for the quality of ECEC, little is known about the nature of the qualifications and the role that they play in developing the knowledge, skills and attitudinal competences needed to best enhance the quality of ECEC provision. The research will focus on ECEC qualification requirements, structure, content and characteristics across Europe. The project will analyse (via secondary data) the qualification requirements across Europe, the composition of the qualifications and their relationship to child outcomes. This macro level analysis will be supported by a detailed investigation (via empirical research) into the delivery of qualifications and the role they play in developing the knowledge, skills and attitudinal competences appropriate to the context. The detailed investigation of qualifications will consider the formulation, delivery, experiences and application of ECEC higher education training in the hosts institution, selected for its expertise in training kindergarten pedagogues in Hungary. ECEC in Hungary is under explored, whilst also offering an interesting case to study due to how its history, market composition and quantity of provision contrast with those experienced by the Fellow in the UK. Pertinent for this research is emerging evidence on the divergent views of the knowledge, skills and attitudinal competences needed to work in ECEC.;109679,4;109679,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DEBRECENI EGYETEM;HU;;; 195545;658070;2DNano;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Beyond Graphene: Fundamental properties of 2D materials at the atomic scale;1/08/2015;31/07/2017;;"The aim of the 2DNano project is to further the development of a high potential European researcher, Dr. Garnica, in the field of nanotechnology through an ambitious research programme that straddles the interface of physics, chemistry and engineering. The project is taking place for two years at the Chair E20 at Technische Universitt Mnchen, a leading institution for nanoscience and nanotechnology. The main goal of the proposal is the synthesis and atomic level understanding of novel two-dimensional (2D) structures on metallic substrates.
The success of graphene has spurred tremendous expectations and research efforts in the development of novel 2D materials with outstanding structural and electronic properties. In graphene, the superlative electronic properties are a consequence of its characteristic band structure, linear near the Fermi level, which convert it in a semimetal. Nevertheless, a large variety of electronic properties, including band gaps and electron mobilities, can be found in the direct analogues of graphene such as the insulator hexagonal boron nitride (h-BN) and the theoretically predicted semiconductor silicon carbide (SiC) honeycomb sheets. With the 2DNano project, we will dedicate considerable efforts in designing new synthetic methods for the production of these 2D materials on metallic substrates, in particular SiC on a silver substrate. The fully characterization of these layers at atomic scale by complementary spectroscopy and microscopy techniques will provide us a wealth of information on their chemical, electronic and geometric structure. This crucial information will be important for the further functionalization of such heterostructures with the final objective of adding new functionalities.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET MUENCHEN;DE;;; 195537;658034;AspSync;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unravelling mechanisms controlling asperities synchronization and triggering mega-earthquakes: insights from analog experiments and subduction zone earthquake statistics;1/01/2016;31/12/2017;;"Subduction mega-earthquakes are among the most destructive events on Earth. When affecting very densely populated areas these earthquakes may cause extensive human losses and severe damages, as for the 2011 M9.0 Tohoku-Oki event (Japan). According to the asperity model, a mega-earthquake may occur when regions of the fault that are potentially seismic (i.e., asperities) interact and synchronize failing together. But understanding the physical conditions that are responsible for such synchronization still remains enigmatic. AspSync proposes to tackle this problem using a multidisciplinary approach that combines analog modelling with geodynamics and statistics.
AspSync proposes to develop a 3D mechanical prototype that reproduces the convergent margin features, including interplate earthquakes. This model will feature laterally (i.e., in trench parallel direction) heterogeneous frictional behavior mimicking the asperities that characterize the plate interface. Tuning the physical and frictional properties of asperities, AspSync will systematically test the role of their dimensions, distance, geometry and strength in the synchronization process, unlocking the possibility to infer the physical conditions that lead to the triggering of mega-earthquakes.
AspSync will then link the experimental results with real Earth conditions, studying the feedbacks between geodynamical properties of convergent margins and interplate seismicity aiming to identify the physical conditions that promote mega-earthquakes triggering. AspSync will update and analyze the existing database of global physical properties of subduction zones and interplate seismicity developed at UM2 applying robust statistics (e.g., multi-parametric pattern recognition analysis; analysis of temporal series) to quantitatively estimate cause-effect relationships between geodynamical and seismic parameters.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit de Montpellier;FR;;; 195546;658072;FISHARC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;FISHing Ancient Reasons to address current Concerns;1/10/2015;30/09/2017;;"Europes pristine marine fisheries probably originated in estuarine biotopes rather than on the open shore, while many of what we now consider offshore species were also originally denizens of much shallower waters. These new data do not emerge from traditional historical data, such as landing records, but from a less conventional source: zooarchaeolo-gy. This archaeological data also suggests that estuarine fish were particularly vulnerable to fishing pressure. Through the analysis of pre-historic, historic and modern fish remains from the Iberian Peninsula, FISHARC will explore (1) the origin and evolution of fishing activities in the Northeast Atlantic, and (2) their impacts on fish biodiversity, behaviour and ecology through time and space, with a particular focus on the commercially import species of cod and hake. The project will pair the zooarchaeological expertise of Laura Llorente-Rodrguez, with the state-of-the art biomolecular facil-ities of the BioArCh at the University of York, to 1) develop new molecular methods for accurate fish species identifica-tion; and 2) apply new stable isotope approaches to examine human impacts on the biogeography, trophic level and pop-ulation structure of North Atlantic cod and hake through time. This project will explore a unique source of cultural, ecological and environmental data preserved in archaeological record to generate invaluable baseline data on pre-industrial fish population levels immediately applicable to marine conservation and management issues.

KEYWORDS: fishing origin, fishing evolution, Norhteast Atlantic, ichtyoarchaeology, ecological baselines";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of York;UK;;; 195530;657990;EM-Pillars;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Controlled cryo-EM sample preparation through DNA-Origami pillars;1/08/2015;31/07/2017;;"Electron cryomicroscopy (cryo-EM) is rapidly emerging as a powerful technique for high-resolution structure determination of protein complexes. Despite recent advances, there is still ample room for improvement of this method, in particular regarding sample preparation. Outstanding challenges are reproducibility of freezing conditions to obtain an optimal ice thickness; to prevent unfolding or preferential orientation of proteins against the hydrophobic air-water interface; and a limited accuracy of beam-induced motion correction for relatively small particles. Here, we propose to study how DNA origami objects that are added in with the sample may affect cryo-EM grid preparation. In addition, by examining a variety of DNA origami structures in the electron microscope, we also aim to identify and improve on structural weaknesses in their design. We will test new design strategies, analyse those, and use them for application in cryo-EM. Thereby, this proposal will facilitate both cryo-EM structure determination and the design of nano-tools that are made from DNA.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 195541;658047;Savage Warfare;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Savage Warfare: A Cultural History of British and American Colonial Campaigns 1885-1914;1/10/2015;30/09/2018;;This innovative project will provide a comparative cultural history of British and American colonial campaigns in Africa, South Asia and South East Asia, between 1885 and 1914. The project will provide a comprehensive study of what was known as savage warfare that goes beyond the conventional military histories by examining the cultural assumptions and colonial knowledge that underwrote military practice. The project aims at making a substantial contribution beyond academia, and the historical exploration of colonial warfare cuts to the very heart of contemporary debates on the war on terror and the continuing legacies of imperialism. The Experienced Researcher will expand his area of expertise on British imperial history to include American imperial and military history, as well as undertaking extensive archival research in Britain, the United States, India and the Philippines. The ER will spend 24 months during the outgoing phase at the History Department at George Washington University to receive training and gain new knowledge within the area of American imperial history. Following this, during the 12 months of the return phase, he will be hosted at Queen Mary, University of London, to transfer back the acquired knowledge and further consolidate his knowledge in the field. The deliverables of the project consist of two articles in per-reviewed journals and the completion of one book manuscript. The ER will furthermore organize two workshops in the United States and one major international conference at QMUL upon his re-integration into the ERA. The undertaking of this multidisciplinary project, that ties together European and American imperial history in a highly original manner, will significantly enhance the career opportunities of the ER and allow him to establish himself as a world-leading historian of imperialism and conflict.;269857,8;269857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195585;658303;East-West;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploring the Eastern and the Western Debate: the Case of Mathematics Teachers Professional Knowledge and Students Achievement - A Comparative Study between Germany and China;15/02/2016;14/02/2018;;"International comparative studies (e.g., TIMSS or PISA) found that East Asian students outperformed their Western counterparts, which raised the interest in comparative studies between Eastern and Western cultures significantly. Educational policies in many countries have been revised referring to the results. However, the question how to explain students achievement differences referring to the professional competence of the teachers and the teaching-and-learning processes provided by them has not been in the focus of studies.
In view of this, the proposed project aims to investigate differences and similarities of mathematics teachers professional competence and the relation to students learning outcomes in Eastern and Western cultures with Germany being the Western protagonist and China serving as protagonist for Eastern cultures. Approximately 300 mathematics teachers and their students (about 8,500) in China and in Germany will participate in the study. Mathematics teachers professional competence will be evaluated using adapted instruments in a previous international comparative project on teachers knowledge (TEDS-M) and a follow-up study (TEDS-FU) through the means of web-based and video-based testing. Students mathematics achievements and their achievement progress over one year will be evaluated using regular achievement tests at national level in China and at Federal level in Germany. Similarities and differences of Chinese and German mathematics teachers professional competence and its connections to students mathematics achievements will be analyzed. Social and cultural influences will be further explored for a mutual understanding of the differences and similarities. Based on these results recommendations for the change of German and Chinese teacher education and teacher-in-service-training will be formulated and concrete suggestions will be disseminated broadly. Long-term collaboration with China is in planned following the fellowship";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET HAMBURG;DE;;; 195577;658258;EPICA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploring Photon-photon Interactions with Cold Rydberg Atoms;1/09/2015;31/08/2017;;"'The requirements for the basic building blocks of Quantum Information Processing (QIP) are sometimes contradictory: one must seek components that are immune to interactions to preserve their fragile quantum properties, and, at the same time, to have strong, controllable interactions to perform operations on the quantum information they carry.

Different implementations using atomic, solid state or photonic systems have different strengths and weaknesses, so there has been a growing interest in the study of hybrid systems, that combine different technologies to implement those basic building blocks.

Photons are the best system to transfer quantum information, because they travel very fast (as fast as it is possible) and are virtually immune to losing their quantum properties; however, photon-photon interactions are very weak, and most materials only show nonlinearities at high photon numbers.

Recently, it has been shown that Rydberg atoms can mediate strong, controllable interactions between individual photons, thus being an ideal system for QIP tasks. 'Exploring Photon-photon Interactions using Cold Rydberg Atoms' (EPICA) is a project aimed at exploring the effective photon-photon interactions mediated by Rydberg atoms. The aims of this project are three:
To combine Rydberg atoms with externally generated single-photons.
To describe in a fundamental way dipole-dipole interactions in the context of multiple stored photons in a highly interacting medium (Rydberg atoms).
To apply this fundamental knowledge to implement basic building blocks for Quantum Information Processing, such as two-photon gates, that could eventually work with single-photons that can be entangled; or others such as a Fock state discriminator or a Fock state emitter.'";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 195544;658061;iRhom2 in AD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;iRhom2 in neuroinflammation and pathogenesis of Alzheimers Disease;1/12/2015;30/11/2017;;"Alzheimers disease (AD) is the most common form of dementia in the elderly, a syndrome characterized by loss of memory and cognitive decline. AD has a dramatic socio-economical impact that is foreseen to worsen in the near future unless a cure is found. The pathology is triggered by the accumulation of A? oligomers that begins a cascade culminating with the formation of neurofibrillary tangles within the neuron and cell death. Neuroinflammation is emerging to play a key role in this process and it has been associated with the progression of the disease.
The rhomboid-like protein iRhom2 has been recently identified as a genetic risk factor for AD, even though the underlying mechanism remains to be characterized. iRhom2 recently emerged as a novel pro-inflammatory protein required to traffic TACE (tumor necrosis factor-? converting enzyme) towards the plasma membrane and guide its maturation, thereby regulating the release of TNF?, a cytokine implicated in several inflammatory diseases. Consequently, iRhom2-/- mice are protected from sepsis and rheumatoid arthritis, which involve TNF?-dependent inflammation. In addition, the concept is emerging that iRhom2 may regulate trafficking of additional clients other than TACE, thus controlling other signalling events in neuroinflammation. The main objective of this proposal is to characterize the role of iRhom2 in neuroinflammation and in the progression of AD. I plan to cross an AD mouse model with iRhom2-/- mice and evaluate role of iRhom2 in the progression of the disease. In addition, I will use avant-garde proteomic approaches to identify novel iRhom2 clients in primary macrophages. Candidates relevant in neuroinflammation and AD will be further validated using an array of biochemical and functional assays. From this research I aim to identify new targets to develop therapies for treatment of AD, in line with the objectives of H2020 Work Programme to promote healthy ageing of the EU citizens.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Klinikum rechts der Isar - Technische Universitaet Muenchen;DE;;; 195445;657439;TOP-DOL;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Topological physics in tunable optical lattices;1/06/2015;31/05/2017;;"The project Topological physics with disorder in tunable optical lattices aims at developing a new experimental setup to explore topological material properties and topological quantum phase transitions using cold atoms in optical lattices.
The project will be carried out during 24 months in the Ultracold Quantum Gases group at ICFO (Barcelona) under the supervision of Dr. Leticia Tarruell.
As envisioned by Feynman in 1982, and realized in recent years, cold atoms system can be used to simulate complex condensed-matter quantum problems. Using ultracold quantum gases, one can build topological systems with geometries and in regimes that go beyond what can be currently realized in solid-state systems with the additional advantage of an unmatched control over interparticle interactions and disorder.
In my project, I will develop the study of topological materials and the interplay between topology and disorder using bosons and fermions in tunable graphene-like lattices. The use of disorder will here be essential to directly characterize the topological robustness which is a key property of topological materials. Furthermore, I will study the manifestations of topology both on the bulk and the edge of the system whose properties are related through the celebrated bulk-boundary correspondence, which shows that the edge states stem from global topological properties of the system and do not depend of the specific shape of the edge.
After a successful Ph.D in Toulouse and a postdoctoral experience in Cambridge, I came to ICFO where I have been working for 10 months, building from scratch the experimental setup. Although already well advanced, this project will thus contain a construction phase to implement the tools that will allow me to perform the proposed experiments and shed a new light on key concepts of topological materials.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 195566;658186;FRAMING_EFFECTS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Experimental Analysis of Framing Effects via Observation of Decision-Making Processes to Improve the Real-World Applicability of Decision Research in Economics;1/10/2015;30/09/2017;;"Fellowship objective is to explain influences of descriptive context on individual decisions, i.e. framing effects, by observing processes of making-sense (of representation/interpretation/rationalization). Experimental Economics ignores effects of framing on this black-box of decision-making processes, and instead theorizes framing by observing only choices & using fixed preference structures. This not only limits our understanding of these effects but weakens real-world applicability of experimental results & leads to inefficient use of public funds; e.g., it is well-established that descriptions used in policy tools, e.g. contingent valuation (CV) & nudging, significantly affect results, yet it is unknown why or how. To unpack this box, fellowship at U. of Nottinghams Centre for Decision Research & Experimental Economics (CeDEx) will combine Dr.Islers background in methodology research with training/research on framing to develop 2 new experiment designs. Secondment at Leeds U. Centre for Decision Research will enable training on Process Tracing Methods (PTMs) & Mouselab software to provide capacity for process observations. Using PTMs/Mouselab in experiments at CeDEx, 1st design will isolate framing effects that choice/preference-based conventional theories cannot explain; 2nd design will analyse these effects in CV-like public good setting to develop probabilistic/structural model to forecast & PTM-based nonconventional theory to explain the effects. To allow sector/policy applications of lab results (e.g., to CV), designs will be used in field experiments at health/fundraising SME secondments, where training on patient/donor interaction & gender/ethics issues will prepare proper implementation. Fellowships training-through-research will thus launch a career in PTM-based framing research leading to innovations in Horizon 2020 health/efficiency/gender priorities that save public/private funds via appropriate reframing of customer relations & policy tools.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF NOTTINGHAM;UK;;; 195569;658197;HiCapWDM;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High Capacity WDM System;1/09/2015;;;"The ever-increasing capacity demand in optical fiber communications is currently being addressed in three ways: a) Increasing the data rate carried by each wavelength channel in wavelength-division multiplexed (WDM) systems by using advanced optical modulation formats which offer improved spectral efficiency compared to legacy On-Off Keyed formats, b) reducing the unused bandwidth between channels by precisely controlling the transmitter wavelength and channel spacing, and c) using flexible transmission techniques to tailor the optical channels to the traffic demands in real time.
A key component that enables all three of these techniques to be addressed is a low-linewidth optical comb source. The low-linewidth allows the high-order modulation formats to be used. The comb line spacing is precisely controlled so that adjacent channels will not wander independently and interfere with each other. The spacing between the lines can also be controlled to change the channel separation in order to allow different modulation formats and especially different symbol rates for the individual sub-channels. This allows the system to adapt to optimize the bit rate and/or modulation format depending on the available bandwidth and properties (dispersion, noise, loss, etc.) of the transmission link. For this adaptation, enhanced digital signal processing (DSP) algorithms are used. The goal of this project is to investigate high-capacity, cost effective, flexible WDM transmission systems, employing optical frequency combs and enhanced DSP technologies.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;;; 195698;658997;ExMeCy;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cyclone processes leading to extreme rainfall in the Mediterranean region;1/05/2016;30/04/2018;;"Mediterranean cyclones are among the most important natural hazards in the region, affecting more than 135 million people. The physical mechanisms that make Mediterranean cyclones evolve into severe storms are not yet fully understood due to many uncertainties in the underlying atmospheric processes. These processes are mainly associated with deep convection and air-sea interactions at meso-scales, as well as with large-scale atmospheric systems that affect the region. The scientific objective of the project is to show how these processes lead to extreme rainfall in the Mediterranean and contribute to the better forecasting of cyclones induced extreme rainfall.
Analysis within ExMeCy is based on a multi-methodological approach that includes fundamental atmospheric dynamical analysis, analysis of lightning and satellite observational datasets, and modelling adapted to the project needs. First the Researcher will detect the cyclones causing extreme rainfall. Then, he will classify these cyclones according to the contribution of the main processes associated with extreme rainfall, namely the deep convection and the airstreams of warm conveyor belts. Different cyclone groups will be thus formed, which will be analyzed separately using new modelling and diagnostic techniques, applied for the first time to Mediterranean cyclones. The decomposition of the complex interactions of atmospheric processes that lead to cyclones intensification and extreme rainfall will constitute ExMeCys original results. These results will be eventually used to assess European services models to predict cyclones-related high impact weather in the Mediterranean. The project will be hosted at the Institute for Environmental Research & Sustainable Development (IERSD) of the National Observatory of Athens (NOA).";152653,2;152653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATIONAL OBSERVATORY OF ATHENS;EL;;; 195609;658467;THz Photochemistry;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;THz Photochemistry: Biased Proton Transfer by Ultrafast Electric Fields;1/04/2015;31/03/2017;;"Ultraviolet or visible light induces chemical transformations via electronic excitation. Infrared radiation, corresponding to low-frequency molecular vibrations, can also bring about photochemical reactions by multi-photon absorption. Then, how low photon energies can we reach in photochemistry? In this proposed research, I will realize a novel concept of terahertz photochemistry: activating chemical reactions with intense terahertz (THz) light of extremely low photon energy (1 THz = 4.1 meV).
Based on this novel approach, I will study aqueous proton transfer in external electric fields, the process underlying key bioenergetic phenomena as well as renewable energy technologies. Despite its obvious relevance, it has remained elusive how E-fields affect the known proton transfer mechanism in aqueous systems. Ultrashort THz pulses, on the one hand, will allow monitoring the THz photochemical proton transfer reactions in real time on the femtosecond time scale. On the other hand, THz light pulses will also serve as external E-fields, which bias the proton transfer reactions.
Due to recent technological development, sub-picosecond strong field THz pulses on the order of hundreds of kV/cm with near single-cycle duration can be generated in the host laboratory, and the short pulses allow for ultrafast time resolution of ca 300 fs. Systematic studies varying field strengths and solvents will provide important insights into the local and external E-field effects on the proton transfer and the non-equilibrium solvation dynamics. The possibility of THz control over proton transport processes will also be examined by applying THz pulses at different delay time after photo-initiation.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195515;657853;GCP-GEOTARCTIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Geochemical-physical coupled study of the modern Arctic Ocean: GEOTRACES-ARCTIC;1/07/2015;30/06/2018;;"Climate-driven alterations of the Arctic Ocean (sea ice cover, hydrography, circulation) strongly influence biological productivity and ecosystem structure. At present, our ability to evaluate the full impact of these changes and predict their future trajectory is limited by a poor understanding of the interacting chemical, physical and biological processes which shape the functional characteristics and resiliency of Arctic waters. To bridge this critical knowledge gap, a pan-Arctic field study (Arctic-GEOTRACES) is being coordinated between Canada (2015), US, Germany and France to generate a quasi-synoptic database of biogeochemical tracers in relation to circulation and ecosystem structure and productivity. The Canadian program involves 28 investigators including biological, chemical and physical oceanographers, experimentalists and modelers.
Fully integrated in this program, the proposed research focuses on tracers of ocean circulation and land/ocean chemical exchanges (Rare Earth Elements, ENd, 230Th, 231Pa), both impacted by climate change in the Arctic. It will be conducted on the Canadian section, from the Canada Basin to the Labrador Sea, and consists of a three-step approach:
1) Modelling study of Arctic Ocean dynamics, including off-line Lagrangian analyses to refine the sampling strategy for the tracers above-mentioned;
2) Measurements of these tracers on the Canadian section to specifically investigate land-ocean exchanges and circulation;
3) Integration of these data into a fine resolution model coupling circulation, sea ice dynamics and biogeochemical processes to refine our understanding of circulation and to quantify land-ocean margin chemical exchanges of bioactive or water mass fingerprinting chemical elements.
Besides enriching international databases, results from this program will provide foundational information critical for sustainable development in the Arctic.
Secondment/return phases: UBC (Vancouver, CA)/LEGOS (Toulouse, FR).";250160,4;250160,4;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195768;659315;OVOC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Leveraging the antioxidant role of volatile isoprenoids for improving grapevine resistance to ozone and temperature stress;1/08/2015;31/07/2018;;The first aim of the project is to prove a general mechanism for plant protection from abiotic stresses (such as temperature and ozone stress) exerted by volatile isoprenoids (VIPs). Recent studies advanced the hypothesis that VIPs may function as effective antioxidants in plants by directly reacting with reactive oxygen species (ROS) that accumulate upon abiotic stress, producing oxidized VIPs. However, this mechanism is yet to be confirmed. During the outgoing phase (Harvard University, Cambridge MA, USA) the objective described above will be addressed via a comprehensive experimental approach that will be carried out on the model plant Arabidopsis (wild-type and isoprene-emitting transgenic Arabidopsis), on a plant species (Quercus rubra) that emits very large quantities of VIPs and on grapevine, a crop of outmost importance in the European economy. During the return phase (FEM, Trento, Italy) the multidisciplinary expertise gained in the outgoing period will be fully employed to study the grapevine germplasm owned by the return institution and new grapevine varieties selected or genetically modified for the emission of specific VIPs, which have recently been developed by a partner research group, in collaboration with the applicant. The final objectives of the project are 1) to prove that VIPs act as effective antioxidant on grapevine leading to an improved ozone stress resistance and 2) to integrate screening for VIP emission in the host institution grapevine breeding program in order to improve stress resistance of new grapevine varieties.;244269;244269;H2020-MSCA-IF-2014;MSCA-IF-GF;FONDAZIONE EDMUND MACH;IT;;; 195562;658173;NAP-QDYS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nitroaromatics photophysics and photochemistry: a quantum dynamics study;1/02/2016;31/01/2018;;Nitroaromatics are a vast group of molecules of interest in different fields of research and applications: for example urban atmospheric contamination, energy materials and to the drug delivery sector. The simplest nitroaromatics compounds are nitrobenzene, 1-nitronaphthalene, and 2-nitronaphthalene. The study of such systems will then constitute the most natural starting point in order to investigate the properties of the nitroaromatics group of compounds. Moreover these three particular molecules are characterized by important and in some case unique photophysical and photochemical properties. For example, 1NN is the organic compound with the fastest multiplicity change ever measured. Recently, an increasing interest in NB has occurred in relation to the so-called roaming radical reactions, which are a new type of reactions that follow a mechanism not contemplated in transition-state theory. With the present project, we aim to characterize the photophysics and photochemistry of the related systems NB, 1NN and 2NN under UVA/UVB exposure through the computation of ab initio quantum chemical dynamics simulations. In particular we will study: their main decay paths, the intersystem-crossing process toward the triplet manifold, the mechanisms leading to the photoisomerization of the nitro into a nitrite group, including the possibility of roaming radical photoisomerization, and the competition among all the mentioned processes.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195500;657732;EvoNovo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genetic architecture of an evolutionary novelty: the development of the male-specific turban-shaped eyes of Cloeon dipterum;1/01/2016;31/12/2017;;Evolutionary innovations are biological revolutions: new organs are critically associated with the emergence of new species and their exploitation of new niches. Despite their importance in the history of life, how morphological novelty arises and evolves is a long-standing question in Evolutionary Biology. In this proposal, I will address the genetic basis of the emergence of one of the most striking examples of a sexually dimorphic novel structure. Males of the mayfly species Cloeon dipterum develop, in addition to the compound eyes (shared by males and females), an extra pair of extremely large dorsal, turban-shaped eyes. To unveil the genetic forces that control the specification and development of this new visual system, I will combine a number of experimental approaches, including non-invasive imaging using X-Ray microtomography, gene expression analyses, genomics, transcriptomics, epigenomics and genome editing to knit a gene regulatory network. This network will be mapped in time and space onto the developing structures and it will help finding which genetic changes trigger the development of the turbanate eye and how these changes operate. This research will represent one of the most detailed studies to understand what are the genetic causes underlying morphological novelties. In addition, establishing C. dipterum as a model will serve as a foundation for further investigations in an organism placed in a key position in the phylogeny of insects, creating a new scientific line for my future establishment as an independent researcher.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195647;658724;FertilityPolicies;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fertility, Public Policies, and Women in Turkey in Comparative Perspective;15/01/2016;14/01/2018;;This project aims to analyse the development and nature of the fertility policy in Turkey in the last decade under the rule by the AKP (Adalet ve Kalkinma Partisi Justice and Development Party). Some of the policy measures were first introduced as a part of legislative harmonization for the countrys EU accession process, while the decline in fertility rates has not been a pressing issue for Turkey as it is for EU countries. However, the policy programme, now famous with the slogan of minimum three children, was gradually developed by the AKP government against the background of its broader political agenda of cultural conservatism and economic liberalism. Accordingly, the fertility policy, the project claims, rests on two major goals: to counteract the changing position of women in society and to increase the countrys competitiveness as an emerging market economy. The project will examine the origins of the policy, the nature of policy measures and institutional change, and their gender implications. Drawing on the perspective of historical institutionalism, the project is designed as a qualitative case study, employing the methods of process tracing and comparative and interpretive analysis, and a variety of data collection strategies such as archival research, semi-structured interviews, and secondary sources. It will make significant contributions to the fields of comparative fertility policy studies, EU policy transfer, and historical institutionalism, with a unique case study of a context of late industrialization and political Islam. It will also contribute to public debates and women-friendly policy advocacy initiatives in Turkey.;145845,6;145845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOC UNIVERSITY;TR;;; 195570;658224;hetero-MOF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rational design of novel heterometallic MOFs for their use in heterogeneous catalysis for cascade reactions;1/05/2015;30/04/2017;;"'The field of metal-organic frameworks (MOFs) is currently among the most extensively studied topics in chemistry given the large number of fascinating applications associated with the chemical versatility of MOFs. In particular, the use of MOFs as heterogeneous catalysts is an area that has attracted considerable attention since, in principle, the ideally suited architectures of MOFs can present catalytically active sites spatially arranged. With the expansion of this area, a new emergent class of heterometallic metal-organic frameworks (hetero-MOFs) has recently been considered for the study of an important type of reactions from an industrial point of view in which two or more individual reactions are carried out in a single step ('tandem' or 'cascade' reactions). However, the synthetic approach for the preparation of these hetero-MOFs has been mainly conducted by post-synthetic replacement of ions with the same oxidation state, with lack of control over the final composition.
The project herein described focus on the design and preparation of novel hetero-MOFs with enhanced stability to perform as superior heterogeneous catalysts. With this purpose, a reasonable straightforward method is proposed, consisting in the low temperature synthesis of hetero-MOFs using pre-designed heterometallic secondary building units (SBUs) as starting materials. The main challenge lies in the control of the metal stoichiometry based on cations with different oxidation states and therefore very different chemical reactivities. The catalytic performance of the novel hetero-MOF materials will be tested during a secondment of excellence already established in the hetero-MOF project.'";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195529;657956;IASS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Immigrant Activity-Space Segregation: Spatio-Temporal Patterns of Assimilation and Separation in Barcelona;1/01/2016;31/12/2017;;This project will deepen societys understanding of immigration while enabling a young, experienced researcher to acquire new skills by collaborating with a well-established European research group with a long record of high quality academic output. The project will help illuminate the lives of immigrants in Barcelona, focusing on their use of space and time as a way to understand the process of assimilation and barriers to social and economic inclusion. Drawing on the expertise of UPFs Interdisciplinary Research Group on Immigration (GRITIM-UPF), the researcher (John Palmer) will interview and observe a panel of immigrants over time to learn about their routines and about the places and people with which they come into contact as they go about their daily activities. The researcher will use newly-developed mobile phone geolocation methods to quantify systematic differences in the spatio-temporal distributions of immigrants and natives, while using traditional qualitative approaches to analyse the social significance of these segregation patterns.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitat Pompeu Fabra;ES;;; 195514;657852;YAKUT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genomics, epigenomics and transcriptomics of Yakutian horses, a unique domestic breed adapted to life in the Arctic;15/09/2015;14/09/2017;;Yakutia (Sakha Republic, Russian Federation) is the coldest country in the Northern hemisphere with winter record temperatures as low as -70C. Despite such extreme conditions, the Yakut people succeeded in developing an economy based on extensive horse and cattle breeding. In contrast to cattle, that are parked in stables at winter, horses do not receive much human care, living all the year in the open air and grazing on vegetation that is under deep snow cover for 7-8 months. Unsurprisingly, Yakutian horses developed amazing adaptations to life in the cold Arctic, including exceptional hair densities for domestic horses and spectacular capacities for regulating their metabolism. The origin of Yakutian horses is controversial. In the YAKUT project, we will use cutting-edge genomic tools including genomics, transcriptomics and epigenomics, together with state-of-the-art methods in ancient DNA research, to reconstruct the evolutionary history of Yakutian horses from its mysterious origins to its adaptation to life in the Arctic. Our extensive genomic dataset will provide essential information to foster efforts for developing sound management strategies to preserve this unique genetic heritage. Following seasonal gene expression levels and associated epigenetic modifications at the whole genome scale, we will reveal for the first time the mechanisms responsible for the exceptional metabolic adaptations found in Yakutian horses. Overall, the YAKUT project aims at understanding the process of natural selection underlying the adaptation of a domestic breed to life in an extreme environment.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195551;658091;Nano Structured Emulsion Foods;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;AYURVEDIC BIOACTIVE COMPOUNDS STABILIZED PICKERING DOUBLE EMULSIONS- FABRICATION AND IN VITRO EVALUATION;1/07/2015;30/06/2017;;"Ayurveda is ~5000 years old healing science which was originated from India with the concept of use of natural ingredients for health purposes such as curcumin, quercetin etc. Ayurvedic bioactive compounds (ABC) can potentially be used to control chronic health problems such as obesity by the targeted and controlled release of bioactives. The use of these bioactives in complex food products is limited as they are sensitive to various factors such as pH, temperature etc.
Recent advancement in application of nanotechnology to food product development offers an opportunity to allow enriching food products with bioactive molecules isolated from ayurveda or any other medicine system by applying the learnings developed for pharmaceutical nano drug delivery technology, in particular nanocrystals technology. The project has two interrelated objectives: (1) fabrication of nanocrystals of ABC to modulate solubility, wettability etc.; (2) use of these nanocrystals as edible Pickering particles to control emulsion functionality (stability, rhelogy, and digestibility). As the particles will be used for stabilization, and also as bioactive (i.e. dual functionality) this system will be unique. The interfacial layer of ABC will allow the control of the emulsion functionality without using high concentration of emulsifiers which are generally used to stabilize emulsions. Fatty acids in emulsion will help improve the bioavailability of ABC. Success in this project will seed and lead the development of innovative formulation strategy for healthy food product development by reducing the use of synthetic emulsifiers (PGPR) thus impacting on consumers and industry.
This will be possible by combining the pharmaceutical drug delivery technology expertise of the experienced researcher with the food delivery expertise and more engineering oriented approach of the supervisor with the intersectoral collaboration between University of Birmingham & Unilever, Netherlands.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195554;658120;SEADOG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sea ice across Dansgaard-Oeschger events in Greenland;1/10/2015;30/09/2017;;"The Last Glacial climate of the Northern Hemisphere was punctuated by abrupt millennial scale changes called Dansgaard-Oeschger (DO) events, clearly recorded by Greenland ice core temperature proxies. The underlying mechanism responsible for the recurring cycles of ~10C rapid increase, followed by gradual cooling, remains uncertain. Many studies suggest that large changes in sea ice extent played a major role in their causation. Sea ice is closely linked to climate; changes in sea ice extent feedback positively on Arctic temperaturea phenomenon of great relevance to the future of Arctic sea ice in our changing climate. This project combines Greenland ice core chemistry records with atmospheric chemistry transport modeling in order to constrain Arctic sea ice variability across DO events. Records of sea salt (Na\), and methane sulphonic acid (MSA), from four ice cores will be analysed for spatial and temporal variability across DO events. The controls on marine aerosol deposition over the Greenland Ice Sheet will be investigated using a atmospheric chemistry transport model, Cambridge p-TOMCAT, which has been successfully deployed for the Antarctic. The relative influence of sea ice and other factors e.g., meteorology, on ice core chemistry variability will be assessed using sensitivity tests that will also provide an indication of the gross sea ice changes in required to reproduce the significant sea salt changes recorded in ice cores. Furthermore, an atmospheric chemistry transport model, that can be interfaced with fully coupled ocean-atmosphere climate model output, will be optimised according to our findings. This model will be run with palaeoclimatic boundary conditions to obtain scenarios of sea ice change consistent with the ice core chemistry data. Separate tests will constrain the magnitude of sea ice retreat at the onset of DO events and the temporal evolution of sea ice conditions as climate cools from warm interstadial to cool stadial conditions.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195632;658614;MoStMusic;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Models of Structure in Music;1/09/2016;31/08/2018;;"Music is an art form with a very long history, and continues to engage millions of people today. Music Information Retrieval (MIR), the exciting interdisciplinary science that brings together music and computer science, is a growing field of research with the potential to enrich computer science knowledge while creating real-world applications that everyone can benefit from. While the marriage of art and science is often troublesome, MIR has the benefit that many aspects of music are highly structural and have been subject to formalisation for a long time. Formalisation and computers go hand in hand, and MIR researchers have therefore been developing models of musical structure for many years, and putting them to use in several applications. However, such models, so far, have had limited impact; they're commonly restricted to one specific aspect of music, can be hard to implement computationally, and are often too technical to be used directly by musicologists who are not familiar with programming details.

However, models are valuable. Unlike machine learning approaches, model-based MIR provides a real insight about the underlying structure, and can benefit from the input of musicologist experts. Furthermore, a single model can be applied to multiple important MIR tasks. The research goal of this project is thus to give musical models the impact they deserve, advancing the practical embodiment of hierarchical musical structure-in its various forms-in computer science through the development of new, functional Models of Structure in Music (MoStMusic). Specifically, I intend to develop functional models of musical form, melody, and harmony that enable an easy, fast, and flexible way of creating model-enhanced MIR applications. As a showcase of such an application, I will create an online music analyser that automatically computes the structure present in a user-submitted piece, and displays it in an interactive interface that highlights the structural shape of music.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 195499;657726;AsymHalogenation;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Intermolecular Asymmetric Halogenations of Olefins;1/05/2015;30/04/2017;;The main goal of this project is the development and optimization of the first general methodology for intermolecular asymmetric halogenation of olefins and the application of NMR spectroscopy to understand and control this process. The carefully controlled application of nucleophiles in intermolecular asymmetric halogenation would be extremely desirable because it could be used as a powerful tool to generate a wide array of structural motifs of exceptional impact for the society. In this project, the asymmetric catalysis is proposed by stabilizing a bispyridine halonium complex in a chiral environment during both reaction with the olefin and subsequent attack of the nucleophile, i.e. a stoichiometric amount of stabilized complex will react with the double bond and then be exposed to the incoming nucleophile, all under the regime of the generated chiral environment. Thus, the project will encompass the synthesis of structurally diverse bispyridine ligands and their halonium complexes and then, the elucidation of the influencing factors on the kinetics of the halogenation reaction by UV and NMR spectroscopy. Ultimately, the knowledge gained in this part of the project will be transferred to the design of bispyridine ligands containing asymmetric centers to induce chirality in the halogenation reaction. One or several series of ligands will be produced and screened for chiral induction via chiral HPLC of the product mixture. The applicability of the approach on several different model reactions will be proven. The chiral products should be obtained with a high degree of regio- and enantioselectivity. The bispyridine ligand used to form the stabilized complex can be recovered by extraction or precipitation and therefore its use is expected to be feasible in large scale reactions. Chiral haloalkanes, the products of asymmetric halogenation, are crucial building blocks and intermediates for the synthesis of pharmaceuticals and functional materials, for example.;185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 195522;657883;SUSAMIDE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sustainable Synthesis of Amides;1/04/2015;31/03/2017;;Despite the ubiquity of the amide group, its synthesis is not always straightforward and the existing methods for amide formation score badly from the perspectives of economy and sustainability. This proposal aims to develop unprecedented methodology for amide synthesis, allowing one to access challenging representatives. Two routes are proposed to mitigate risk and to provide complementarity. The objective of the proposal is twofold: 1) to expand the available chemical space (allowing one to synthesize challenging amides previously considered inaccessible via library synthesis with existing methods) and 2) to substitute existing syntheses with better ones (delivering higher yields without using toxic reagents and minimizing waste). Achieving these two objectives will have an impact on the discovery of new molecular entities and the improvement of production processes in the fine chemicals sector. The power of the new methodology will be demonstrated on the synthesis of selected real-life examples, APIs (Active Pharmaceutical Ingredients).;172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT ANTWERPEN;BE;;; 195531;657988;RNA-SHAPE;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structure and function of repeat-derived non-coding RNAs in epigenetic regulation of mammalian pericentric heterochromatin;1/05/2015;30/04/2017;;"A significant fraction of mammalian genomes is composed of repetitive elements, such as pericentric major satellite repeats. Repetitive elements present a critical challenge to genome stability because these regions are prone to recombination. To safeguard genome integrity, these repetitive sequences are maintained in an epigenetically silent heterochromatic state to prevent mutagenic recombination. A confounding enigma revealed by recent transcriptome-wide studies is that repetitive elements are actively transcribed into noncoding RNAs (ncRNAs). Furthermore, these repeat-derived transcripts are themselves important to maintain the heterochromatic structure at repetitive elements. Nevertheless, it appears that a certain balance must be achieved since overexpression of repeat-derived ncRNAs is a hallmark of the most common types of cancer. How repeat-derived ncRNAs function in epigenetic regulation of heterochromatin is poorly understood. In this proposed study, ncRNAs transcribed from mouse pericentric major satellite repeats will be investigated as a paradigm to understand the precise mechanism of how these ncRNAs regulate heterochromatin formation. The key element of the proposed study is characterizing the function of major satellite RNAs from a structural perspective. This is a novel and promising approach because the functions of RNA molecules are intimately linked with their ability to fold into complex structures. A possible scenario is that accurate folding of major satellite RNA directs the local recruitment of chromatin complexes to pericentric loci. To address this hypothesis, the proposed research programme aims to achieve the following: (i) determine the structure of major satellite RNAs; (ii) determine if major satellite RNAs are divided into functional domains and how this relates to the structure; and (iii) determine how the structure of major satellite RNAs influence their interaction with pericentric DNA and chromatin-associated proteins.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195555;658126;MarkEfficiency;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Digestive and nutritional indicators of feed efficiency in cattle fed forage-based diets;1/09/2015;31/08/2017;;As the human population approaches 9.5 billion in 2050, and societies as a whole become more affluent, the demand for meat and milk is projected to nearly double. The current challenge facing humanity is to achieve food security in a sustainable manner. As such, sustainable livestock production must be targeted towards the efficient use of feeds not suitable for human consumption. As a result of their symbiotic rumen microbial population, ruminants are strong targets for manipulation as they can convert fibrous forages and low quality nitrogen sources into high protein meat and milk. Evaluation of the feed efficiency of ruminants fed non-competitive feed resources is an important avenue to increase the profitability and sustainability of European ruminant farming systems. Feed efficiency is a complex trait that is lengthy and costly to phenotype. Additionally, in order to provide a comprehensive evaluation of the sustainable phenotype, newer sustainability parameters, such as methane emissions and nitrogen losses need to be incorporated. Metabolism and digestion have been described as the two most important physiological drivers of variation of feed efficiency in ruminants. Thus, the objective of this proposal is to explore potential biomarkers and microbial indicators of feed efficiency in growing cattle fed forage-based diets to improve our understanding of the physiological basis of efficient animals. Using feed conversion efficiency and residual feed intake as benchmark indexes of efficiency, we will test and improve the use of modern isotopic N fractionation and rumen microbial phylotyping techniques as practical tools to evaluate feed efficiency in ruminants and to better understand and correlate the rumen microbial community signature to an efficiency phenotype. These biomarkers could be used as an early evaluation tool in young animals and in commercial settings for selection and assessment of nutritional management problems.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;;; 195536;658031;GenSPI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genomic Selection for Potato Improvement;21/09/2015;20/09/2017;;Ireland produces potatoes locally to satisfy its indigenous crisping industry. However, over 50,000 tonnes of potatoes still need to be imported each year due to problems with the long term storage of locally produced product. Potatoes destined for crisping are normally stored at 8 degrees, below this glucose accumulates leading to very dark fry colours and potential acrylamide build up. Unfortunately, sprouting occurs above 8 degrees and impacts product quality. This necessitates the use of sprout suppressant chemicals such as chlorpropham. The EU is moving to phase out the use of such chemicals due to health concerns, and it is therefore necessary to develop potatoes that can be stored below 8 degrees without suffering from low temperature sweetening (LTS). LTS is under polygenic control and therefore challenging for traditional breeding programmes, particularly when it needs to be combined with other traits such as yield and disease resistance. This is where new breeding methodologies such as genomic selection (GS) can assist traditional programmes. GS is a form of marker assisted selection that simultaneously estimates all loci, haplotype, or marker effects across the entire genome to calculate Genomic Estimated Breeding Values (GEBVs). GEBVs are then used to select individuals for advancement in the breeding cycle without direct phenotyping. GEBVs for characteristics such as resistance to LTS would radically enhance potato breeding and lead to the development of more suitable processing varieties. This proposal involves directly aligning a pilot GS programme to a traditional breeding programme to evaluate the potential for GS in potato breeding. We envisage that GS will enable the screening of an extremely large number of individuals at a seedling stage, ensuring that only the most valuable material is advanced for extensive and expensive phenotyping. This will enable a dramatic increase in the genetic progress for the development of improved potato varieties.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY;IE;;; 195753;659227;STOMMAC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Stochastic Multi-Scale Modelling for the Analysis of Closed-Loop Interactions among Brain Networks;1/07/2015;30/06/2017;;Brain functions likely emerge from the concerted, context-dependent operations of its microscopic and macroscopic networks. Therefore, the organization and operational principles of such complex systems may be best investigated by using multi-modal approaches, including concurrent measurements of neural activity on multiple spatiotemporal scales. Performing and interpreting such multi-scale measures, though, presents enormous challenges for both experimental and mathematical neuroscientists. Existing analysis methods, however, make limited use of newly acquired concurrent multi-scale information. To dramatically advance analysis methods for these data, I propose a novel multi-scale model that bridges the gap between single cell statistics and neural mass signals. The model describes mixed discrete statistics, covering single cell and small population spike trains, as well as continuous statistics, such as those describing mesoscopic and macroscopic measures of mass neural activity in neuroimaging experiments. These elements are combined by means of copulas, describing multivariate interactions within and between scales of activity. I will extend this method to the level of efficient applicability and, in the course of a secondment with Prof. Logothetis at the Max Planck Institute in Tbingen, exploit the technique to solve current problems of multi-scale analysis of interactions between cortical and subcortical brain areas. The new mathematical approach will lead to a set of new tools that I will disseminate in an Open Source format for maximal impact, and will be widely applicable to multi-modal recordings in animals and humans, in both research and clinical settings. My own application of this method to multi-modal datasets will establish a deeper general understanding of the mechanisms of large-scale communication among brain areas, with particular emphasis on the principles of communication among networks involved in the formation of declarative memory.;168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;IT;;; 195547;658073;seQureNet;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Secure information processing in quantum networks;15/04/2015;14/04/2017;;"The promise of future quantum computers to substantially speed up computations has been advertised widely since the early days of the field. But there is a novel and fundamental aspect of devices based on quantum-mechanical principles that has just started to be explored: Quantum computers can preserve the privacy of computations. This aspect is a distinct new advantage of quantum computers over their classical counterparts. An entire class of unprecedented computations becomes feasible, in which the user data and the whole computation remain perfectly private a feature impossible to achieve with classical computers. The main focus of this project is to exploit this feature and to implement secure photonic quantum information processing in distributed quantum networks. These networks consist of clients and small-scale quantum computers connected by communication channels. Photons are chosen as they are the ideal carriers for sending information over long distances. The clients can securely delegate computations to the quantum computers, such that neither the data nor the computation is revealed to the computers or any potential eavesdropper. The project will, first, elucidate how quantum resources boost the security of classical computations; second, demonstrate secure quantum computations over long distances and study their verification; and third, examine practical security aspects of implementations. The research will leverage the experimental state-of-the-art by adapting new photonic quantum technologies such as integrated photon sources and waveguide quantum circuits. Moreover, highly-efficient superconducting detectors will be applied to achieve excellent quantum control of the photons. This research is highly innovative and will be pivotal in the researchers career development and for becoming an independent research group leader, as it enables acquiring both key scientific knowledge and developing complementary skills.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195485;657672;NATCONSUMERS;SIGNED;H2020-EU.3.3.6.;LCE-20-2014;H2020;NATural Language Energy for Promoting CONSUMER Sustainable Behaviour;1/05/2015;30/06/2017;;"Residential energy consumption represents the 28% of all EU consumption and if commercial buildings are also considered this percentage increases to 40% (36% of EU CO2 emissions). In this context, is clear that the reduction of consumption in the residential sector should play an important role in energy efficiency programmes and policies as is stated in the recent Energy Efficiency Directive 2012/27/EU.
Most energy efficiency measures implemented in Europe involved technological interventions. In contrast, everyday energy-consuming behaviours are largely habitual and therefore the potential of energy savings at home with actions focused in consumer behaviour is really promising. In this context the provision of feedback to consumers has resulted in really promising results, achieving savings in the range of 5-20%. But some limitations exists. The aim of this project is to fill the gaps and advanced in this context, being an essential preparatory activity for the future large scale demonstration of feedback methodologies.
The key aim of this project is to develop an advanced and integral user-centred framework for the implementation of efficient energy feedback programmes in the domestic area. Our approach relies in the complete characterisation of the EU energy consumer, and the design of specific personalised actions tailored to each consumer pattern detected based on the use of natural language and emotional contents. NATCONSUMERS will set the scenario to allow strengthening the dialogue between the EU energy system stakeholders in order to define robustness methodologies exploiting to the maximum the potential of energy feedback approaches, filling the existing gaps not still covered by previous pilots and experiments.
NATCONSUMERS consortium brings together representatives of all stakeholders and areas involved in the project. A concise dissemination and awareness programme is proposed to reach the target communities and increase the impact of the project.";2048278,75;2032528,75;H2020-LCE-2014-2;CSA;ARIOSZ SZOLGALTATO INFORMATIKAI ESTANACSADO KORLATOLT FELELOSSEGU TARSASAG;HU;"STATENS INSTITUTT FOR FORBRUKSFORSKNING;VAASAETT LTD AB OY;STRATEGIC DESIGN SCENARIOS SPRL;VALOR DESARROLLO E INNOVACION SL;FUNDACION PARA EL PROGRESO DEL SOFT COMPUTING;HOGSKOLEN I OSLO OG AKERSHUS;THE ENERGY SAVING TRUST LIMITED;DRAXIS ENVIRONMENTAL S.A.;RICERCA SUL SISTEMA ENERGETICO - RSE SPA;IZERTIS SOCIEDAD LIMITADA;ASSOCIAZIONE ITALIANA DIFESA CONSUMATORI ED AMBIENTE";"NO;FI;BE;ES;UK;EL;IT"; 195448;657452;ACTIVE_MARS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Active Surface Processes On Mars: A Laboratory, Field And Remote Sensing Study;1/03/2016;28/02/2018;;"This study will identify and analyse ongoing geological activity across the whole of Mars in the form of the changing morphology of kilometre-scale classical gullies (Fig. 1). From this, we aim to determine whether these changes are caused by the action of liquid water, or dry frost (water or carbon dioxide). Such a study addresses key questions of ongoing martian habitability, planetary protection (i.e. limiting access for future missions to possible wet environments) and current climate. Jan Raack, the Experienced Researcher (ER), has just published a study of one such gully: this can be used as a methodological template for a more ambitious project.

The core of the project is a global search for change in martian gullies using 25cm/pixel HiRISE images. Thermal and spectral data will be used to determine the types of volatiles that are present as changes occur, thus constraining the triggering mechanism for flow. The core task is supported by Earth-based field work and laboratory experiments using a Mars simulation chamber. This multidisciplinary approach, combining remote sensing, field, and laboratory work is a powerful methodology, and also provides great skills development for the ER.

Significant outreach and communication activities are a vital part of the project. We will use a variety of media (blogs, Twitter, conference presentations, press-releases of papers etc.), and also apply to the UK Royal Society to be part of the annual Summer Science Exhibition. Preparing for the proposal and the exhibition will provide a key learning experience for the ER, and develop proposal writing, public communication and project management skills.

The three key outcomes of the project will be two peer-reviewed papers describing the distribution and triggering mechanism of martian gullies based on a synthesis of field, remote sensing and laboratory studies, and the Exhibition at the Royal Society, where the project results will be communicated to thousands people.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE OPEN UNIVERSITY;UK;;; 195433;657332;PEERS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Peer effects and endogenous network formation;1/06/2015;31/05/2017;;The aim of this project is to develop a theoretical and empirical framework to simultaneously study network formation and peer effects in education. The problem is important from a methodological perspective, as there do not exist general purpose estimatable models of social dynamics in Economics which treat the network formation process as endogenous and simultaneously contemplate network effects on behaviour and its feedback on the network formation process. The possibility of understanding the formation of social networks in terms of the characteristics of the agents forming links is severely limited in most applications by the presence of peer effects that alter these characteristics. Conversely one of the main difficulties in measuring peer effects in any context is that peer groups are endogenous. This project will have two main components (1) a theoretical component and (2) an empirical/experimental component. The theoretical component aims to construct and study in detail the properties of some models of peer effects treating network formation endogenously. In the empirical/experimental component I will estimate and test the models by (a) Relying on two datasets, one of which already exists and one of which is under construction, and which I am currently using on two related projects and (b) Building a detailed longitudinal dataset including information on social network structure and various kinds of behaviours and attitudes using surveys and economic experiments.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACI MARKETS, ORGANIZATIONS AND VOTES IN ECONOMICS;ES;;; 195516;657861;MIGWAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating the interactions between civil wars and migration.;1/10/2015;30/09/2017;;"Poor countries are often plagued by civil wars. They are also, in many cases, emigration countries. Anybody interested in the development of such countries must understand to what extent these phenomena are interrelated, and how they interplay with each other. If it is pretty clear that civil wars push people to leave the country, it remains understudied how diasporas play a role in the emergence and evolution of violent conflicts.

Indeed, the interactions between diasporas and conflict have roughly been overlooked by the economic literature to date, in spite of the very suggestive pieces of evidence provided by related research fields and of the very important policy questions that it raises in particular, how to optimize the contribution of diasporas to peaceful development. Based on case studies such as those of Erytrea or of Sri Lanka, the literature in history and political science underlines diverse mechanisms through which diasporas have intervened in the evolution of violence in their home country, either as peace-builders or as peace-wreckers. On the other hand, in these case studies, the evolution of civil wars also appears to have been determinant of emigration and return migration patterns and, eventually, of the nature of diasporas involvement in the political situation in the homeland.

This project will investigate the joint dynamics of civil conflicts and migration in developing countries. It will first build a theoretical framework to characterize how diasporas and civil wars interact together, accounting for the endogeneity of both migration and violence. The theoretical predictions derived from this framework will then be empirically tested, relying on recent and original data. Through a multi-disciplinary perspective, nourished by the findings of the qualitative research and relying on economic tools both theoretical and empirical this project will allow to build the first comprehensive investigation of the diasporas conflict nexus.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CATHOLIQUE DE LOUVAIN;BE;;; 195507;657765;BAIPFeOTC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bis(alkyl-imidazolyl)propionate (BAIP) based bio-inspired mono-nuclear non-heme iron(II) complexes that catalyze challenging oxidative transformations of organic compounds;1/09/2015;31/08/2017;;"Here we propose the development of a new class of facial triad N,N,O ligands based on the bis(alkyl-imidazolyl)propionate (BAIP) architecture for the synthesis of bio-inspired mono-nuclear non-heme iron(II) complexes that have the ability to selective catalyze challenging oxidative transformations of organic compounds using oxidants like H2O2 or O2. Our specific aims will be:
(i) To develop new sterically encumbered BAIP-ligands for the generation of highly reactive 1:1 Fe/ligand complexes,
(ii) To develop inverted amide versions of these ligands to generate Fe-amido complexes with low oxidation potentials for O2 activation,
(iii) To study the reactivity towards oxidants (H2O2, O2) and the catalytic properties in challenging oxidation transformations (alkane hydroxylation, alkene cis-dihydroxylation) of the corresponding iron complexes.
(iv) To carry out detailed mechanistic investigations on isolated and/or spectroscopically well-characterized iron complexes and intermediates that are involved in the reactivity of the new Fe-N,N,O complexes.
The project will follow the so-called synthetic analogue approach, where small model compounds are developed to mimic the structural and functional features of metallo-enzyme active sites. In doing so, the model compounds may aid in the further understanding of metallo-enzyme reactivity and mechanism. At the same time the model compounds may be further developed into new synthetic catalysts. Carrying out this project within the Organic Chemistry and Catalysis (OCC) group at Utrecht University will place the candidate in the middle of the research activities of the Catalysis Centre Utrecht (CCU). This will allow the candidate to develop his knowledge and skills in the fields of bioinorganic chemistry and homogeneous catalysis, to further shape him for a future research career in the broader fields of molecular inorganic chemistry and molecular catalysis.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 195594;658352;MitoTAGs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Developing next-generation tools for mitochondrial dissection with cell-specific resolution.;1/05/2015;30/04/2017;;Mitochondria generate most of the energy cells require to function. Deficits in the mitochondrial energy-generating machinery affect 1:5,000 children and cause progressive, debilitating, and usually fatal pathologies collectively known as primary mitochondrial disease. To date, there is no cure for mitochondrial disease and existing treatments are highly ineffective and mostly palliative. High-energy-requiring cells, such as neurons, are especially affected in mitochondrial disease. However, not all neuronal populations are equally affected. Furthermore, the molecular determinants of neuronal vulnerability to mitochondrial disease have not been adequately elucidated, representing a challenge for the development of efficient treatments for these pathologies. To improve on current knowledge on mitochondrial disease and to provide better therapeutic targets, this proposal focuses on developing ground-breaking molecular biology tools that will allow the identification and dissection of the molecular determinants of neuronal vulnerability in mitochondrial disease with unprecedented definition. I will develop novel techniques to isolate the mitochondrial translatome by using ribosomal tagging, as well as to assess intact mitochondrial function, with cell-type specificity. These novel approaches will have a high impact in mitochondrial disease research, with the overall aim of identifying novel therapeutic targets that will lead to effective treatments for mitochondrial disease. Furthermore, the high applicability of the tools generated will allow significant breakthroughs in the research of other pathologies with mitochondrial affectation such as diabetes or neurodegenerative processes.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT AUTONOMA DE BARCELONA;ES;;; 195430;657309;GLOBALGLASS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Global Glass Adornments Event Horizon in the Late Iron Age and Roman Period Frontiers (100 BC - AD 250);5/10/2015;4/10/2017;;The project is multidisciplinary comparative research on the cross-cultural consumption of personal adornments, known as glass annulars, i.e. rigid, ring-shaped objects composed of coloured glass, used by the inhabitants of the European northwest borderland regions during the transition from the Late Iron Age to Roman period, c. 100 B.C. A.D. 250. This project introduces the pan-European glass adornments event horizon, which signals the existence of an active multicultural community with its own forms of decorative identification in the borderland regions. It will assess the evidence for this phenomenon, firstly, in four north-western European countries: Germany, the Netherlands, Belgium, and United Kingdom, and, secondly, explore its regional ramifications, by concentrating on one area, United Kingdom, in order to understand the manifestation of this inter-cultural event in a local setting. The project combines thorough literary and museum research with scientific and hands-on experiments, and pays particular attention to engaging and disseminating the results to the wider public. It challenges long-standing perceptions related to the function and gender nature of glass adornments. It investigates the mobility of materials, artefacts and craftspeople, and reconstructs the networks of interethnic craft interaction in borderland zones. It analyses the transformative role these annulars played in the formation of inter-European and regional identities in a transitional period when new cultural forms and practices emerged in the European Northwest.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 195540;658045;MED-FARWEST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Urban Centres and Landscapes in Transition. The Mediterranean FarWest in Late Antiquity;1/11/2015;31/10/2017;;MED-FARWEST is a strongly innovative project that, focussing on the territory located in the far west of the Roman Empire, namely the Iberian Peninsula, will analyse two of the most interesting yet poorly understood phenomena of the crucial period of Late Antiquity (AD 300-700): 1. the complete abandonment of some cities and 2. the dismantling of the Roman rural world. Both phenomena have long seen consideration by a variety of independent researchers, but without satisfactory depth and explanation to the issue. This proposed project will be the first to apply a comprehensive multidisciplinary approach, exploiting techniques developed especially in the sub-discipline of Landscape Archaeology, in which the rural and urban worlds are analysed as a single unit, and thus as part of a single reality in transformation. Hispania provides an ideal test-bed for the study given the results of new fieldwork, an availability of relevant sites (urban/rural), and recent published outputs. The applicant and the proposed Host (University of Leicester) and Partner Organizations (the CSIC-National Research Council of Spain and CINECA of Italy) can draw upon a rich vein of expertise, specialists, research, publications, equipment and infrastructure to generate data, models and results for this project. The approach to be developed will be of major value for addressing other aspects of Roman-late antique transformation in Hispania (urban, rural, social, demographic, economic), but, crucially, will also provide guidelines for analyses elsewhere in the Empire, thus enabling much closer dialogue in approaches and debates both for Late Antiquity and for other periods.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Leicester;UK;;; 195738;659189;WALKEr;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Robot-induced Error Augmentation for improving pre-gait and gait rehabilitation in stroke survivors;1/10/2015;30/09/2017;;Robotic assisted gait training (RAGT) for stroke rehabilitation is promising but it has not met the expectations of the clinical community yet. Several studies have demonstrated the effectiveness of this approach, but, as now, RAGT has not been demonstrated to be superior to standard gait training. The research community is thus focusing on developing novel training methodologies for RAGT in order to fully exploit its potential. Emphasis has been given to training methodologies that promote and maximize the active participation of the patients. The Error Augmentation (EA) paradigm has been successfully developed and proved effective for the upper limbs. In the EA paradigm, perturbations are used to amplify the movement error of the patient in a way that induces a compensatory motor plan that rejects the augmented error. This approach has been applied to the lower limbs by means of split-belt treadmill training, where the speeds of the belt are set in order to amplify gait asymmetries and promote an adaptation toward a less asymmetric gait pattern. However, EA has not been applied in RAGT. Its implementation in RAGT can extend the target of this therapy to several other gait parameters. In WALKEr we plan to develop the EA paradigm on both a robotic ankle device and a six degrees of freedom (DoFs) exoskeleton for gait rehabilitation. Both developments will then be tested on healthy subjects and chronic stroke survivors to assess the potential of this technique in improving motor adaptations, motor learning and rehabilitation.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS;DE;;; 195532;657995;embryonic rosettes;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating embryonic development at the time of implantation using embryos and ES cells;1/02/2016;31/01/2018;;The mouse embryo is an excellent model for human development. Its preimplantation stages of development in vitro have been extensively studied. Now similar approaches can be applied to implantation stages, previously hidden from view in the uterus. It was recently revealed that formation of a rosette structure by pluripotent epiblast cells can be recapitulated by ES cells cultured in extracellular matrix proteins. I will determine the extent to which such rosettes can undertake autonomous development or if they require flanking extraembryonic tissues. I will characterise the patterns of the normal development of these tissues from the point of implantation to the time of gastrulation. I will determine the extent to which explants of extraembryonic tissues can influence the development of rosettes of epiblast cells. Altogether, these experiments will expand our knowledge of embryonic development and how to manipulate the developmental potential of pluripotent cells.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195579;658265;CHRISLAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Christian Diversity in Late Antique Sirmium (ca 350 ca 450): A Historical, Literary and Theological Study;1/09/2016;31/08/2018;;This research follows a Christian community situated on the edge of Central Europe and the Balkans during an intense period of struggles towards its self-definition amongst religious dissent, socio-cultural diversity and political and military hardships. All these resulted in a regionally coloured Christianity, the main characteristics of which are visible in the material as well as literary heritage of this community. The setting is the 4th - 5th century A.D. Sirmium modern Sremska Mitrovica (Serbia). At the time, Sirmium was one of the capitals of the Roman province Pannonia, an area which now comprises parts of modern Austria, Hungary, Croatia and Serbia. It is vital to understand the history of religious diversity and identity in that region, which continues to puzzle Europe with its rich cultural heritage, but also with its controversial political, ethnical and religious past. This research will contribute to the better understanding of European culture, and its religious and cultural memory, reinforcing the idea that the concrete realization of Christian identity varies according to context and that there is a complex relationship between religious diversity and identity in a particular place. Once verified with regard to Sirmium, this type of research can be extended to other places / regions in the late antique Mediterranean world. In particular, the applicant envisages a long-term research project on Christian identity in Roman Pannonia and a network of late antique Middle Danube studies. All these will lead to the pursuit of a tenure-track academic position that will enable the applicant to implement this larger Pannonian research. The University of Exeter is the ideal location: it is a growing centre of Late Antique studies, with a cluster of research projects on Identities and beliefs in the ancient world. The fellow will extend her skills by being in Exeter, and will contribute her linguistic and historical expertise to their on-going research.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EXETER;UK;;; 195539;658041;PEATmod;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;PEATland modelling for global carbon cycle and climate models;1/03/2016;28/02/2018;;Prediction of future climate change can only be achieved through models of the global climate system and its interactions with earth system processes. The reliability of the predictions depends on building the best understanding of these processes. Changes in the global carbon cycle are a source of major uncertainty in models and terrestrial carbon stored in peatlands is a critical element of this. The action proposed here will bring state-of-the-art process modelling into global vegetation models that are used in projections of future climate change. An improved understanding of peatland dynamics and functions will also have implications for management and climate mitigation strategies for wetlands, agriculture, land-use, and energy. I have worked extensively in North America on one of the most sophisticated peatland process models. I will work with Dan Charman and Angela Gallego-Sala at Exeter to build this model in to one of the most widely used dynamic global vegetation models so that peatlands and their carbon balance are better represented within global climate models. The work will thus allow quantification of the impact of peatlands on the global carbon cycle in the past and in the future. The action will bring top level expertise in peatland modelling back to Europe and build a bridge between the North American peatland modelling community and those in Europe. It will expose me to training and development in the necessary skills, people and laboratories to take this work forward independently in a European institution in the future. The supervisors at Exeter will develop their already strong record in carbon cycle and climate modelling and further develop links with other European workers and key groups in North America. Overall the action will provide a secure launch pad for my career, bring cutting edge skills to Europe and build stronger and long lasting linkages between European and North American science.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE UNIVERSITY OF EXETER;UK;;; 195418;657251;ASTROMULTISCALE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multiscale dynamics of astrophysical plasmas: pressure-anisotropy-driven instabilities and large-scale dynamical processes;1/06/2015;31/05/2017;;"The primary purpose of the proposed project is a deeper understanding of instabilities in plasmas and their influence on transport phenomena and large-scale dynamical processes. The studies will be focused on nonlinear regime of development of the firehose and mirror instabilities triggered by pressure anisotropy spontaneously generated in stellar-wind environments by large-scale expansion/compression effects and plasma turbulence. Recent studies of microphysics of the instabilities have provided systematic knowledge on saturation effects in nonlinear regime and related wave-particle interactions. This opens a possibility of investigation of a feedback between the microphysics and large-scale dynamics. The project is anticipated to provide answers to the questions: what is the effective collisionality of a pressure-anisotropic plasma that is unstable or marginally stable to the firehose and mirror instabilities and how does it change the effective pressure tensor (viscous stress) used in fluid description of plasmas?

Results of the project are expected to be important for general plasma physics as related to the problem of multiscale phenomena in plasmas and coupling between microphysics and macrophysical processes. In particular, the results can help in better understanding of the dynamics of galaxy cluster plasmas, dynamical processes in stellar winds and planetary magnetospheres.

The studies will be done by numerical simulations using state-of-the-art kinetic and fluid models of plasma dynamics. A numerical setup will be developed analogous to experimental setups used for classical viscosity measurements in fluids. This virtual setup will be used to measure stresses caused by development of instabilities in plasmas. A related problem of thermalization of microinstabilities into kinetic waves cascade will be also investigated. The entire modeling framework will be validated by comparison of simulation results with spacecraft measurements in turbulent solar wind.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195415;657240;ICONOPHILIA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Religion, Politics and the Arts in Early Medieval Italy Against the Background of the Image Struggle (680-850);1/08/2015;31/07/2017;;This project will specifically focus firstly on the development and dissemination of the theological matters that affected the policies of the Roman Catholic Church between the late seventh-mid ninth century, and secondly on the translation of these theological matters into a literary and visual imagery. In the period 680-850 a great debate about the cult of sacred images the Byzantine image struggle or iconoclasm engaged monks, emperors, popes. Sacred images have for different reasons ispired devotion or spurred iconoclastic reactions and cultural opposition world-wide and often in human history unfortunately also in the last fifteen years. The place of sacred image in the actual Christian religious mentality i.e. the way in which cult images stimulate reactions, are perceived, venerated, chosen as personal talismans and intercessors with the divine in contemporary culture was radically shaped by the intense period of the Byzantine image struggle. The political, cultural, and artistic interactions and the developments of Christian mentality between the West and the East during this phase are actually still a grey area in Medieval and Byzantine studies, having been dealt with only occasionally and compartimentally. By using literary as well as visual evidence, 'ICONOPHILIA' will explore this grey area and prove to be significant to a range of scholarly disciplines, while being appealing also to a wider global audience interested in religious mentality, Church history, history of monasticism, cultural policies, visual thinking, art production and consumption as socio-political statements. The Centre for Byzantine, Ottoman and Modern Greek Studies in Birmingham will provide the ideal intellectual environment for the development of this interdisciplinary project.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195683;658902;OSS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spatio-temporal control of the Src kinase activation through Optogenetics in Cell invasion;1/03/2016;28/02/2018;;Cell signaling is a complex system that coordinates cell actions in response to environmental inputs. Signaling pathways are often seen and investigated as on/off networks, but the reality of the intensities and spatio-temporal organization of these networks has been poorly integrated with the dynamics of cellular outputs in response to specific environmental inputs. In the OSS project we aim to approach this general problem by focusing on a specific cellular function, cell invasion (the hosts area of expertise). We propose to 1) use the formation of invadosomes, characteristic acto-adhesive structures important for cell invasion as a specific cellular function, to address these fundamental questions 2) and target the pleiotropic tyrosine kinase Src that has the ability to induce cell invasion globally by acting on cell adhesion, migration, contractility and invadosome dynamics independently of any environmental regulation, to investigate how a biological signal can be dynamically encoded into specific multifarious cellular outputs. Our hypothesis is that specific spatio-temporal patterns of Src activation could be the basis of its pleiotropicity. Thus, the first step of the OSS project will be to use Src biosensors to observe different patterns of Src activation and correlate them with the dynamics of Src-dependent cellular outputs (such as induction of invadosomes). Secondly, we will directly control spatio-temporal Src activity in live cells using optogenetics, a powerful and innovative approach that will allow us to mimic the observed patterns of Src activation and to create new patterns in order to explore dynamic equilibrium between Src signaling and its specific cellular outputs. This project is at the cross-road of signaling theory in biology, cell biology of acto-adhesive structures and biotechnology fields. The goal of the OSS project is to actively manipulate signals in space and time with the ultimate aim to control dynamic process of cell invasion.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195617;658512;HumanitarianPassions;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Humanitarian Passions. The Survival of Christian Iconography in Contemporary Representations of Pain: a Visual Studies Approach;15/06/2015;14/06/2017;;"My research project aims at contributing to understanding the role played by mass communications in contemporary humanitarian crises, through a comparative study of representations of pain in the history of Western iconography.
The main objective is to analyse a corpus of humanitarian communications and identify their models in the history of the iconography of past centuries. Specifically, I intend to study the relationship between the images of contemporary humanitarianism and representations of the Passion in the history of Western visual arts. My hypothesis is that Christian iconography constitutes a database of images on which the media rely implicitly to create situations charged with pathos and suffering and to suggest a moral attitude to the audience.
The qualifying methodology of my work is to compare images from different historical periods. Using the approach of Visual Studies I will be able to increase the knowledge of Christian iconography in the light of humanitarian communications, and to understand the effectiveness of the latter in a direct comparison with the repertoire of the Passion in Western art.
The research will focus on a set of multimedia documents (NGOs campaigns, films, paintings...). The general hypothesis will be developed according to four sub-objectives: 1) To analyse the narrative, passional and axiological organisation of Christian iconography as expressed in exemplary works. 2) To analyse humanitarian communications of European catastrophes. 3) To analyse humanitarian communications concerning Africa. 4) To study Humanitarian communications as re-interpreted by contemporary artists.
This research project is a significant opportunity to advance the European scientific tradition in Visual Studies. Through the achievement of the sub-objectives, I will study the cultural roots of humanitarianism, improving the understanding of communications in traumatic situations and contributing to the implementation of EU polices and practices.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES;FR;;; 195484;657661;Space-Time from Info;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Space-Time from Information Flow;1/12/2015;30/11/2017;;"The aim of this proposal is to develop a novel multidisciplinary approach to space-time physics which combines core features of quantum theory and general relativity by using modern tools of information theory. Recent results manifest a deep relation between space-time structure and the possibility of certain abstract quantum communication tasks. We shall build upon these results to identify precise operational conditions on abstract quantum communication which permit observers to describe their environment as a classical space-time. This procedure will be expanded to spatiotemporal structures in a semiclassical regime with an emphasis on how the feasibility of communication tasks is influenced. Exploiting these insights, we shall devise a novel framework for (quantum) gravitational physics to generating spatiotemporal structure from the internal information flow of an operationally defined network. This research programme may foster new perspectives on space-time physics by providing it with information theoretic foundations and is intended to complement, rather than compete with, already existing approaches to (quantum) gravity.

The fellowship will reintegrate the researcher from Canada into the EU and, at the same time, support the cross-community move of a (quantum) gravity expert into a quantum foundations group. The proposed programme requires expertise from various disciplines in theoretical physics and will thereby diversify the competences of both the researcher and the host group, as well as expand their respective networks of collaborators. This action supports European excellence in science and prepares the fellow for a more permanent position by endowing him with crucial opportunities to train his mentoring, communication and networking skills and, ultimately, by allowing him to develop his own research programme.";178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN;AT;;; 195521;657877;FACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Francophone African and Caribbean Theaters;1/06/2015;31/05/2017;;The cultural and artistic expressions of Black minorities are still unknown, devalued, and understudied in France today where exclusion and discrimination keep growing. Therefore it is urgent to analyze and recognize the work of African and Caribbean dramatists who embody the diversity and multiculturalism of our global contemporary world. The goal of FACT (Francophone African & Caribbean Theaters) is to revisit the history of Francophone Black theaters born out of the brutal encounter of Europe, Africa and the Americas, and to evaluate the effects of colonialism and postcolonialism on contemporary France. This colonial legacy is still denied today although being an integral part of the French national history. As a specialist of Caribbean theater, I will join the Theater studies Department at the University Sorbonne Nouvelle to collaborate with Professor Chalaye, specialist of African drama, to examine plays written by dramatists from Africa and the Caribbean from the 1960s to date. We intend to show that migrations that followed decolonization have transformed, nourished and enriched the French nation. We also want to challenge not only stereotypes and prejudices against Black minorities, but also the conception of a homogeneous unique French identity. FACT will contribute to make Francophone African and Caribbean drama more visible in the field by creating a database of texts and audio/videorecordings and by developing a postcolonial analysis of the materials. The outcome of FACT will create awareness among the general public of the reality of a multi-racial and multi-cultural nation born of a shared colonial history with the ultimate goal to encourage French and European citizens to lose their fears of the Other, to be opened to the difference, and to welcome and celebrate the diversity of Europe.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PARIS III SORBONNE NOUVELLE;FR;;; 195501;657733;ISSVS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Immune system involvement in sex-specific vulnerability to prenatal stress;1/07/2015;30/06/2017;;Prenatal stress (PS) is more detrimental to males than to females. Evidence is accumulating that PS may play an important etiological role in the incidence of neurodevelopmental disorders, which often show a male bias in incidence. The mechanisms underlying the sex-specific effects of PS are still unknown, but recent evidence implicates a crucial role for microglia, the resident immune cells of the central nervous system. Although in the adult brain microglia are activated only after infection or injury, in the developing neonate microglia show a structurally activated pattern, especially in males, which coincides with the critical period for hormonal action that cause sexual differentiation of the brain. Very recently the immune system, with a central role for microglia cells, was found to play a pivotal role in the masculinizing pathway. I hypothesize that the sex-specific behavioral vulnerability to PS is caused by sex-specific activation of neonatal microglia, leading to deficits in synaptic pruning, through epigenetic alterations in microglia, most notable in the COX2 promoter. COX2 is pivotal in the feed-forward mechanism of microglia activation and implicated in neurodevelopmental disorders. I will induce or block neonatal microglia activation to study whether PGE2 is both necessary and sufficient to induce the sex-specific vulnerability to PS and its mechanisms. These experiments may give important novel insights into the sex-specific sensitivity to the prenatal environment, and help understand the male predominance in many neurodevelopmental disorders. Coming from a world-leading lab with the main focus on sex differences in the brain I will bring important new knowledge and techniques to the host institute, while I will be thoroughly trained in state-of-the-art techniques at the interface of neuroscience and immunology at the countrys best research university, creating a novel niche in the field and preparing me for a professorship position in the EU.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITAIR MEDISCH CENTRUM UTRECHT;NL;;; 195470;657566;CONFINES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Controlling Cell Fate through Smart Nanoheaters;9/09/2015;8/09/2017;;Achieving the control of cellular processes is one of the most intriguing challenges in cell biology and medicine. Forefront approaches based on bioengineered nanoparticles might have the potential to target specific cell pathways, thus controlling downstream cell activities in a space and time selective fashion. The present project aims to develop and to validate a smart nanovectorable to activate a specific cell signalling and, on demand, to induce heat mediated cell death of nanovector targeted cells. As proof of concept, CONFINES is conceived to target the Wnt canonical pathway, one of the most studied and fascinating cell signalling, which orchestrates central mechanisms that govern cell proliferation, polarity and stem cell fate. To achieve the proposed objectives, a controlled synthetic approach will tailor Wnt ligands on magnetic nanoparticles, combining targeting and magnetic properties in a uniquenanovector. Owing to its chemico-physical features, NanoWnt will enable complete control of the cell signalling, and it will operate in vitro (human cell cultures) and in vivo (the aquatic invertebrateHydra vulgaris), in a dual mode: i) as an activator of the canonical Wnt pathway in those contexts where it is inactive ii) or upon exposure to a magnetic field, as a nanoheater, enabling specific cell ablation by hyperthermia. From a technological point of view, the project will advance basic knowledge on thermal ablation (via magnetic hyperthermia) and holds promises for translational medicine, providing a breakthrough tool to shape cell fate of nanovector receiving cells. Furthermore, combining diverse expertise, CONFINES will offer the applicant advanced and multidisciplinarytraining in the field of nanomaterial synthesis, characterization and functionalisation as well as in hyperthermia technology, which will complement his current skills based on nanobiotechnology and cellular/molecular biology.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE ZARAGOZA;ES;;; 195517;657865;MAXWELL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Maximising wellbeing and minimising emissions: backcasting social visions for a low-carbon Europe.;14/09/2015;13/09/2017;;The science of climate change demands radical long-term reduction in greenhouse gas (GHG) emissions. In supporting this, EU policy is committed to develop a low-carbon future by 2050 . Key to meeting this target is the contribution of energy and both analysis and policy development have been prioritised. The central planks of mitigation practices globally include technological change and efficiency. It is widely acknowledged that the challenge of mitigation fundamentally requires more , as emissions are dependent on the wider development path and underlying driving forces. Within these concepts exists not only the challenge of more complex analysis, but the opportunity of new ways to reduce energy consumption. A neglected but promising option is to look at the social structures underlying material consumption. The perception of mitigation policy is of cost and loss, but there is potential to deliver mitigation while improving peoples lives, to maximise wellbeing and minimise emissions. This study will backcast scenarios of social wellbeing in a low-carbon Europe of 2050 and how to achieve transition. It begins with the contested links between wellbeing and material consumption. The study is a first, adopting interdisciplinary alternative perspectives rather than a unifying theory. These perspectives will be used to develop an original contribution, different visions of desired social wellbeing in the EU of 2050. The energy implications of social scenarios entailing lower material consumption are unknown, this study is original in quantifying their contribution. An innovation follows by backcasting transition through European policy towards scenarios of future wellbeing and reduced emissions. The proposed study is novel and highly innovative addressing priority gaps in knowledge. It dovetails important contributions to energy research and European society and policy with development of the researchers career and shared benefits for the host institution.;179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TURUN YLIOPISTO;FI;;; 195469;657546;PneumoCompetence;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unravelling the mechanisms of competence induction by antibiotic stress in Streptococcus pneumoniae;1/05/2015;30/04/2017;;"Despite the introduction of several vaccines, the human pathogen Streptococcus pneumoniae remains one of the leading bacterial causes of mortality worldwide, killing 1 million of children each year. In developed countries, the rise of multi-drug resistance in S. pneumoniae during last decade is a serious cause of concern, since the patient is more likely to require hospitalization consuming high health resources, and increasing the risk of death.
The main mechanism by which S. pneumoniae acquire and spread antibiotic resistance is by activation of the competence state that allows the uptake of exogenous DNA. Strikingly, competence is induced by several antibiotics, but the molecular mechanisms driving competence development are poorly understood.
Our approach integrates the use of promoter-luciferase fusions to competence genes, transposon-mutagenesis and -sequencing, total RNA sequencing, knockout strains constructions and time-lapse fluorescence microscopy, to identify clinical antimicrobials that induce competence and unravel its underlying molecular mechanisms. Data generated in this project will provide a better understanding of the mode of action of these antibiotics and give valuable molecular insights into the evolution of antibiotic resistance in S. pneumoniae.
Finally, we will test thousands of pairwise drug combinations in a novel high-throughput screen to identify inhibitors of the competence process. This highly relevant project will provide new pre-clinical data for future novel treatment strategies against bacterial infections and the mitigation of the spread of antibiotic resistance.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;RIJKSUNIVERSITEIT GRONINGEN;NL;;; 195526;657937;Hadza communication;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Communication Development in Infants: the Case of the Hadza Hunter-Gatherers of Tanzania;1/11/2015;31/10/2017;;"The way children learn to communicate verbally and non-verbally depends to a great extent to the culture in which they are raised. Much is known about the social environment of children living in Western societies, but much less is known about how children are socialized in hunter-gatherer societies. The proposed project aims at gaining insights into the development of communication in hunter-gatherer children. The projects aims are
to develop a minimally intrusive assessment method that gives access to the learning process by including physiological measures.
to analyze physiological responses to infants verbal and non-verbal interactions with their social environment focusing on the Hadza, as a particularly interesting cultural community.
extract patterns in data from diverse sources (audio, video, observation, electrophysiological measures) with automated data mining methods.
The approach is interdisciplinary, integrating methods from anthropology and ethology with modern physiological assessment methods, innovative wearable technology and data mining techniques. It is important to know more about the development of communication in Hadza infants as communication in hunter-gatherers has not been comprehensively studied and the Hadza are a community living in conditions that resemble our ancestors living conditions. This helps to shed light on the evolution of language in our species. As hunter-gatherer societies are increasingly threatened due to ecological, economic and political changes in their environment, it is crucial to conduct this research as soon as possible.
My personal training targets are to apply my previous field work experience to a new and interesting cultural community and relate this to theories about the evolution of language, to fruitfully combine methods from different disciplines and learn how to use data mining techniques in order to analyze large amounts of data from various sources.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING KATHOLIEKE UNIVERSITEIT BRABANT;NL;;; 195525;657918;CAPITULA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Variation on a theme: evolutionary-developmental insights into the Asteraceae flower head;1/09/2015;31/08/2017;;Plant reproduction relies on flowers and their arrangement into inflorescence two interrelated traits that exhibit impressive variation between plant lineages and constrain crop yields and horticultural forms. A key aim in evolutionary biology is to unravel how the modification of genetic networks has led to the diversification of reproductive plant architecture and floral form. This project addresses this aim by seeking to understand how two fundamental biological processes, floral architecture and symmetry, have evolved in the daisy family Asteraceae, with unique combinations of these traits. Much of the research on Asteraceae has concentrated on model plant systems with simple heterogamous capitula (e.g. gerbera, sunflower). We propose an original and novel evolutionary-developmental (evo-devo) approach to floral evolution, by bringing to this field the species of Asteraceae with secondary heads (=syncephalia). This unique capitulum architecture has arisen from two rounds of capitulescence (i.e. inflorescence condensation followed by simplification) during their evolution. Syncephalous species which comprise ca. 70 genera from 11 tribes provide an invaluable source of material for deciphering the genetic basis of capitulum evolution since their genomes bear the signature of two inflorescence shifts toward capitulescence. Our approach, integrating the most recent experimental and theoretical developments in evo-devo and genomics fields, provides a unique opportunity to ask fundamental questions relating to coordinated trait evolution, and to increase our understanding of how genetic pathways have been altered or co-opted during the evolutionary diversification of flowers. The knowledge gained has the potential to open up novel molecular breeding strategies for developing improved varieties of horticultural and crop plants in this family of great economical importance (e.g. artichoke, chrysanthemum, gerbera, knapweeds, lettuce, sunflower).;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL BOTANIC GARDENS KEW;UK;;; 195524;657904;PREF LEARNHEUR;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Learning heuristics in preference elicitation tasks: insights from behavioural, computational and neurobiological investigations;1/05/2015;30/04/2017;;Although decision theory assumes that when making a choice, individuals attribute values to available options, compare those values and select the option with the highest, the succession of choices faced during classical preference elicitation tasks might trigger the emergence of additional heuristics, implemented to perform those tasks in a fast, yet adaptive manner. This project aim at pioneering the isolation of such heuristic development, in a dynamical framework where both the task features and the agents own preferences are learned from previous trials, and influence subsequent behavior. This framework suggests that agents preferences will depend on the choice sequence, thus vary according to predictable patterns through different instantiations of the same task. Thereby, it captures a new component of individual preferences, which we refer to as task-related preferences. Combining behavioral experiments, computational modelling and functional brain imaging, we propose to reveal and measure the behavioral variance accounted by the task-related preferences, to model their emergence during the task, and to incorporate them in a coherent neuro-cognitive model of decision-making. Overall, this project will contribute to 1) refine current neurocognitive and economic models of decision-making, 2) train a promising cognitive neuroscientist to tackle human decision issues relevant to social sciences, with advanced quantitative economic/computational tools, and 3) foster fruitful cross-talks between scholars from economics, psychology, and neuroscience at the host institution. The scientific contribution seems particularly important given that preferences are one of the current conceptual cornerstones used to understand our society at the micro- and macroeconomic level, to guide and assess public policies aiming to maximize peoples well-being, to characterize normal and pathological behaviors, and to unravel the neurobiological mechanisms underlying decision-making.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195506;657755;ArtOxiZymes;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Artificial Oxidation Enzymes for Highly Selective Waste Free Hydroxylation of Alkanes;1/10/2015;30/09/2017;;One of the major challenges facing the chemical industries is the sustainable production of chemicals from natural resources. The challenge includes making sure that chemical processes are as green and economical as possible, and that sustainable and abundant resources are used where possible. One type of reaction that lends itself to sustainable processes is the direct functionalization of C-H to C-X (X = O, N, C) bonds, as it generates far less chemical waste and leads to tremendous reduction of energy use than methods relying on prefunctionalized materials. The objective of this project is to achieve the C1-selective hydroxylation of n-alkanes to give n-alcohols e.g. octane to octan-1-ol, using mild reaction conditions and green oxidants such as oxygen or hydrogen peroxide, which is currently an unsolved problem. Linear alcohols are of interest as they form some of the major building blocks used in the chemical industries, for example C8-C10 alcohols for the synthesis of plasticisers and detergents. We will achieve this aim by combining traditional homogenous catalysis and biocatalysis for the development of artificial metalloenzymes as catalysts, which utilise the molecular recognition concepts of nature to bind substrates selectively in protein pockets. The target substrate will thus be bound in the correct orientation enabling selective oxidation at the target position, in contrast to traditional chemocatalysts which give a highly unfavourable product distribution. This will lead to more efficient use of valuable feedstocks and large reductions in chemical waste production and energy consumption, compared to the traditional methods for forming C1-alcohols, all contributing to a green and sustainable society. The researcher will diversify her competence, build new collaborations and gain interdisciplinary mobility through this creative and highly innovative project allowing her to maximise her contribution to the knowledge-based economy and society.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;;; 195493;657682;OPTIMAL NMR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Optimal control methods for biological solid state nuclear magnetic resonance;1/09/2015;31/08/2017;;This project aims at changing the impact of optimal control methodology on solid state nuclear magnetic resonance (NMR). This way, routine structure determination of biological solids like amyloid fibrils and membrane proteins will be facilitated. Multi-dimensional experiments of these samples often suffer from low resolution and sensitivity. Optimal control theory provides efficient means for automated design of pulse experiments with improved efficiency, lower deposited radiofrequency power, and robustness with respect to experimental imperfections. The methodology has already been successfully applied to liquid state as well as solid state NMR. However, and especially for solids, the optimized pulse sequences are not used within the NMR community, probably due to barriers imposed by individual RF hardware characteristics of the employed probes and consoles. In order to change this we propose, in cooperation with the market leading manufacturer of NMR spectrometers, to study the interplay of the hardware with numerically predicted optimal experiments, including relaxation and reformulation of the optimization problem in a new theoretical framework. Such comprehensive optimizations should provide us with easy-to-use building blocks of multidimensional solid state NMR experiments with superior performance, boosting thus the sensitivity and the accessibility of structural information from the acquired spectra. To promote dissemination of the developed protocols a workshop on implementation of optimal control methods in magnetic resonance will be organized. The potential impact of the project is enormous, revolutionizing hardware development with new quality measures that combine its properties with fundamental laws of spin dynamics.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET MUENCHEN;DE;;; 195486;657663;AROSYN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Reflexive Clitics in Aromanian;1/09/2015;31/08/2017;;Reflexive clitics and their role in the argument structure of verbal predicates have posed significant questions for Romance and other languages. This project aims to further investigate the morpho-syntax of reflexive/SE-clitics in Romance and its consequences for argument structure, by studying SE-structures in a cluster of Aromanian varieties spoken in North-Western Greece. Aromanian is a highly endangered and heavily understudied Eastern Romance variety which is closely related to Romanian, Megleno-Romanian, and Istro-Romanian, but which has also been in close contact with Greek. Aromanian has SE-clitics which behave differently from SE-clitics in other Romance languages (including Romanian) in significant ways. One of the aims of this project is to compare the Aromanian SE-structures to those reported for Eastern Romance (with an emphasis on Daco-Romance), and Romance more generally, and to identify the grammatical features responsible for such variation. This project involves extensive fieldwork on a fairly uncharted dialect, based on solid theoretical assumptions, and it differs from previous research in that it follows a micro-parametric approach to dialectal syntax within a small set of closely related varieties.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195455;657492;SpliceosomeStructure;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural role of protein splicing factors in promoting an active configuration of the spliceosome's RNA catalytic core;1/03/2016;28/02/2018;;The spliceosome is a ribonucleoprotein machine that excises introns from pre-messenger RNAs. During my phD, I identified RNA ligands for the magnesium ions that catalyze these splicing reactions and showed that the spliceosomal U6 and U2 small nuclear RNAs form a structure resembling group II self-splicing intron RNAs. Although the spliceosome's catalytic core is RNA-based, numerous spliceosomal proteins promote the proper catalytic fold of this RNA core, juxtapose the reactive pre-mRNA elements with the U6 metal sites, and regulate spliceosome dynamics during the splicing cycle. Indeed, the Prp8 protein cross-links with the critical nucleotides of the catalytic RNA core and its crystal structure, reported recently by the host laboratory, revealed a cavity that accommodates the catalytic RNA core. Moreover, several helicases, such as Brr2 and Prp16, promote an active configuration of the U2/U6 RNA core and associated proteins and regulate their dynamics. The arrangement of such proteins in the assembled spliceosome and their interactions with the RNA core is presently unknown due to the lack of high-resolution structures of any spliceosomal complexes. I will study biochemically in vitro the interactions between the U2/U6 core and key proteins necessary for an active fold of the RNA core, with the goal of reconstituting and solving the high-resolution structure of a minimal active U2/U6 RNA core in complex with the reactive pre-mRNA sites and surrounding proteins including Prp8. In parallel, I will employ recent advances in cryo-electron microscopy sample preparation, imaging, and data processing, which were pioneered at the host institute, to obtain high-resolution (at least 7 Angstroms) three-dimensional reconstructions of endogenous fully assembled spliceosomes stalled at specific splicing stages. These studies promise to provide unprecedented structural insihgt into the configuration and dynamics of key RNA and protein elements of the spliceosome.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 195511;657796;CREST UNDER TENSION;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechano-regulation of neural crest cell differentiation.;1/05/2015;;;"Neural crest cells (NCC) are a unique vertebrate-specific population of multipotent cells that contribute to the development and evolution of the vertebrate head. During embryonic development, cranial NCC give rise to a variety of hard and soft tissue cells including osteoblasts, chondrocytes, odontoblasts, glia and neuronal cells. Whilst we understand a great deal about how growth factors and soluble chemicals determine the generation, migration, proliferation, survival and differentiation of the neural crest, nothing is known about how mechano-regulatory factors influence NCC fate. Recent evidence has shown that mesenchymal stem cell fate and cell behaviours are controlled by mechano-regulatory signals via the actinomyosin skeleton, and the co-transcriptional effectors, Yap and Taz. Given that NCC are similarly exposed to different mechanoregulatory influences from stiff and soft matrices and tensions generated by the differential growth and morphogenesis of adjacent epithelial and mesenchymal structures, it is hypothesized that NCC differentiation is also mechano-regulated. This proposal will use in vitro and in vivo approaches to test this hypothesis and determine if NCC fate is governed by mechano-regulatory signals, the differential regulation of the actinomyosin skeleton and Yap/Taz. The proposal will provide novel insight into the mechanisms of embryonic cell differentiation and craniofacial birth defects. Additionally, as neural crest stem cells have been identified in the adult, it will provide an understanding of how these may be manipulated to generate specific cell populations for tissue repair.
The proposal will test a novel hypothesis and provide research training in a unique interdisciplinary skill set encompassing biology and engineering at the forefront of research field in addition to transferable skills. The Fellow will be mentored by two internationally recognised supervisors, who are experts in developmental biology and engineering.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195502;657739;miRTurnOver;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identifying genes involved in microRNA turnover in Arabidopsis;1/06/2015;31/05/2017;;MicroRNAs (miRNAs) are small non-coding RNA molecules regulating the expression of protein coding genes by targeting mRNAs. Since they play key roles in development and in responses to both biotic and abiotic stresses, it is important that miRNAs are expressed at the right time and place. Therefore there must be a mechanism to degrade miRNAs (miRNA turnover) and that mechanism itself must be carefully regulated to ensure that miRNAs are not present when their function is not required. However, we know very little about this mechanism and its regulation. I propose carry out a mutant screen and identify genes involved in miRNA turnover. The screen builds on previous work of the host laboratory where miR395, a sulfur starvation-induced miRNA, was characterised. The screening assay relies on a sensor, which is a phloem-expressed GFP transgene containing a miR395 target site, to monitor the level of miR395. Expression of miR395 will be induced by low level of sulfur to down-regulate GFP expression. After replenishing the media with sulfur, miR395 transcription is switched off and the existing miR395 molecules will be degraded, leading to green fluorescence recovery in the seedlings. The speed of this recovery is about three days in wild type plants and I will screen for lines exhibiting faster or slower recovery. After validation of the mutant phenotype I will identify the mutatnt genes by either next generation sequencing or classical map-based cloning. Identifying genes involved in miRNA turnover will open up a new fiekd in the RNA silencing area. Understanding the function of those genes and how miRNA turnover is regulated will impact on all aspect of plant biology but also on biomedicine as siRNAs are potential theraputics.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF EAST ANGLIA;UK;;; 195454;657486;NANOCARB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Self-selection of a multivalent nanosystem for carbohydrate recognition;15/04/2015;14/04/2017;;"The main objective of the NANOCARB project is to prepare the experienced researcher (ER) for an independent career through the implementation of a frontier research project and a training programme covering all aspects that are required for running a research group. The NANOCARB project has the scientific objective to build up an original method for the development of an innovative class of carbohydrate receptors using dynamic combinatorial chemistry (DCC) on the surface of a gold nanoparticle. Molecular receptors capable of carbohydrate recognition have a great potential in diagnostics and therapeutics. However, this prospective is still remote as it has turned out that designing synthetic receptor molecules able to selectively bind carbohydrates in water is very difficult. The distinguishing feature of this project is that the recognition site for the carbohydrate target is spontaneously formed, driven by the carbohydrate target itself. The self-selected recognition units will then be immobilized covalently on the gold nanoparticle, yielding a multivalent nanosystem able to recognize its target also in vivo.
The project is on the interphase between chemistry, biology and nanotechnology providing an excellent opportunity for the experienced researcher (ER) to develop skills in these areas. Training excellence within the context of becoming independent researcher will involve manuscript and research proposal preparation, public engagement, IPR issues, networking, and conference organization. The project also benefits from external input and a secondment from other groups (Prof. Lay, University of Milan and Prof. Lombardi, University of Piemonte Orientale) in order to fill lacunes not available at the host institution. The combined package of scientific and training objectives will make the NANOCARB project an excellent platform for kick-starting the independent career of the ER and generating a strong visibility to the host institution.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI PADOVA;IT;;; 195564;658180;LORENZLIDAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Classification of Forest Structural Types with LiDAR Remote Sensing Applied to Study Tree Size-Density Scaling Theories;1/09/2016;31/08/2018;;The main goal of this research is to develop an objective methodology for monitoring forest structural complexity by airborne laser scanning (ALS) remote sensing. Most European countries are currently acquiring low-density national ALS data, by scanning with LiDAR sensors onboard airborne platforms, in the process to obtain full-country coverage and making it publicly available. These datasets are taken in relatively homogeneous conditions, therefore providing with a chance to develop Pan-European indicators and automated unsupervised methods not requiring field data. With the intention of producing a methodology that could be replicated in practice by any forest practitioner, publicly available ALS data from national land surveys of Member States will be used, and unsupervised methods not requiring field data will be developed. The laser partly penetrates the forest canopy, therefore providing an opportunity to study the establishment of natural regeneration in the understory layers. The analysis will be based on the study of the Lorenz curve, a method for which the applicant has obtained promising preliminary results and which the present proposal plans to generalize for more forest ecosystem types and low-density National laser datasets. The diameter distributions will be evaluated with regard to their agreement to metabolic ecology and demographic equilibrium theories. The development of a mathematical framework linking Lorenz ordering to diameter-density scaling relationships will provide with a method for authomated ecological evaluation of forests by means of ALS remote sensing. In practice this means that competition and forest disturbance conditions are different at different forest areas, and we suggest that the Lorenz method for ALS can provide indicators for these conditions. The application will be on a replicable method for forest stratification into structural types from ALS data acquired in national programmes.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195477;657607;FOREST 3D - ECOCARB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Integration of innovative remote sensing techniques for optimum modelling of tropical forest primate habitat and carbon storage;1/10/2015;30/09/2017;;"Tropical forests are being destroyed at a rate of 1.5 acres every second due to human activities, thereby accelerating climate change through impacts on the carbon cycle and causing the extinction of species dependent on these habitats. Over the past 20 years the EU has been the largest net importer of 'embodied deforestation', significantly ahead of trading powers like China or North America. This trend is at odds with EU commitments to halt forest loss and mitigate climate change over the next 20 years.
In the face of such immediate and globally significant issues, there is a lack of robust scientific knowledge on how tropical deforestation and degradation affects ecosystem stability and carbon pools. There is a need to develop systems that can rapidly assess tropical forest structure and relate this to carbon stocks stored in tree biomass and to habitat quality for keystone species, like primates. Remote sensing systems, such as those available from Earth observation satellites or aircraft, can deliver data on forest structure and composition. This project will utilise innovative new methods of acquiring detailed 3-dimensional data of tropical forests at a landscape-scale, using remote sensing systems on aircraft and unmanned aerial vehicles (UAVs), in order to model primate habitat and measure forest carbon stocks. The project will, for the first time, link forest structure in 3-D directly to primate behaviour and forest use, and will develop cost-effective remote sensing methods using UAVs for monitoring changes in habitats and forest carbon stocks.
This innovative project brings together a researcher with expertise in the processing and analysis of data from airborne remote sensing systems, with an internationally recognised group with expertise in remote sensing, geospatial analysis, ecological modelling and primate ecology to evaluate and develop new methods to support a managed and appropriate balance of conservation and economic aims for tropical forests.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BOURNEMOUTH UNIVERSITY;UK;;; 195510;657784;ACTUS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;ACcelerating Transition in Peri-Urban areaS in East Africa;1/01/2016;31/12/2018;;"Behind statements and statistics about newly urbanized populations in Africa, behind maps of rapid and unregulated growth and numerous disaster/risk assessments there are real people with compelling tales of coping and adapting capacities to urban challenges brought by the rapid transformation of cities. Their stories often contain more hope, ambition and imagination as portrayed in reports and scientific publications. Their ability to bounce back despite disadvantageous ecological, economic and political settings implies a new form of normality framed outside traditional city development models.
ACTUS is concerned with people's everyday experiences of solid waste and sanitation in peri-urban areas to discern the interdependences between urban infrastructure, pro-poor growth and climate hazards. In ACTUS I place a particular focus on local processes of adaptation and self-organization to cope with increasing flooding impacts in East Africa. The lens of everyday experiences of waste management and sanitation offers an innovative approach to expend our understanding on multiple spheres of livelihoods considering how local processes and technologies may act as a benefit for the poor and may trigger sustainable technical infrastructure.
ACTUS is not a 'stand alone research project. It is designed to run complementary to a PhD program on 'Urban Infrastructure in transition: The case of African cities from the Graduate School of urban Studies at TU Darmstadt. The benefit of such close collaboration lies in the breath of knowledge I will gain not only within my specific research project but also through regular exchanges with a multidisciplinary group of scholars focusing on urban infrastructure regimes in Africa.";219693,6;219693,6;H2020-MSCA-IF-2014;MSCA-IF-GF;TECHNISCHE UNIVERSITAT DARMSTADT;DE;;; 195471;657569;TRAIT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Exploring the biogeography of thermal acclimation in heterotrophic microbes;1/07/2015;30/06/2017;;Understanding the biological mechanisms governing carbon (C) exchanges between terrestrial and atmospheric C pools, and how these exchanges will respond, and feed back, to climate warming, are among the most urgent challenges for climate and ecosystem scientists. Heterotrophic microbes are dominant biochemical engineers in terrestrial ecosystems, governing the flux of C between terrestrial and atmospheric pools. Despite concerns that rising atmospheric temperatures will stimulate the respiratory release of C by heterotrophic microbes, recent work highlights the potential for thermal acclimation to partially ameliorate this positive feedback. The magnitude and efficiency of this physiological response is, however, highly variable, suggesting that the strength of climate-ecosystem C feedbacks will vary across landscapes. The proposed study uses a combination of trait-based and community-scale approaches to explore the relative importance of microbial community composition and climate conditions in governing patterns of acclimation potential across landscapes. Incorporating this microbial physiological information into Earth System Models (ESMs) is essential if we are to predict global patterns in biogeochemical cycling under current, and future climate scenarios. The proposed work incorporates aspects of microbial physiological biology, community ecology and ecosystem ecology to address a critical uncertainty in current climate models. This interdisciplinary project will allow me the opportunity to exchange knowledge with experts in the fields of microbial community ecology and terrestrial ecosystem ecology at NIOO-KNAW. I will also foster an international collaborative network, which will benefit my host organisation and myself. The proposed fellowship will allow me re-enter the European academic system and develop the skills required to initiate my own effective research group following the project.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;NL;;; 195403;657188;GAMMALAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards gamma-ray lasers via super-radiance in a Bose-Einstein condensate of 135mCs isomers;1/12/2015;30/11/2017;;We propose to realise the first experimental demonstration of gamma-ray coherent emission by means of super-radiance in a Bose-Einstein condensate of 135mCs isomers. The isomers will be produced by proton bombardment and will be then laser cooled and trapped in a magneto-optical trap. The cold atomic sample will be transferred to an optical dipole trap, where, by means of forced evaporative cooling, a Bose-Einstein Condensate will be realised. The 135mCs condensate will satisfy the requirements for gamma-ray coherent emission at 787 keV. The project will lead to several milestones in fundamental physics, thus triggering further novel researches, and will demonstrate the practical feasibility of gamma-ray lasers, that would have numerous potential applications ranging from energy industry to medicine.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195723;659121;AND;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Antibacterial (Nano)medicines Development;1/04/2015;31/03/2017;;Despite the investment of billions of euros, there has been an inexorable decline in the discovery of new antibiotics over the last decades. In this individual fellowship (IF) application we propose a strategy to develop bacterial histidine-kinase (HK) inhibitors targeted at the catalytic and ATP-biding domain (CA) as novel broad-spectrum antibacterial (nano)medicines. Furthermore, putative mechanism of resistance to HK inhibitors and known antibiotics will be studied and novel antibacterial drug targets will be identified by using transposon insertion mutant libraries (Tn-libraries) to identify mutations involved in intrinsic resistance to antibiotics and/or leading to increased sensitivity to existing antibiotics in multi-drug resistant (MDR) strains.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195400;657176;ASB;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Amplitudes, String and Branes;1/10/2015;;;My research focuses on the interrelated areas of scattering amplitudes, string theory, and M-theory. Following Wittens development of twistor string theory, many powerful methods have been developed for computing amplitudes in both gauge and gravity theories. I plan to further develop these methods in order to obtain new insights into the mathematical structure of quantum field theory and string theory. For example, I will extend recent 1-loop calculations using the twistor Wilson loop of N=4 super-Yang-Mills (SYM) to higher loops in order to search for new mathematical structures like cluster polylogarithms. I also plan to make contact with integrability by analyzing the multi-Regge limit of the twistor Wilson loop and searching for integrable deformations which allow one to compute amplitudes using Bethe Ansatz techniques. It may be possible to extend these ideas beyond N=4 SYM using ambitwistor string theory, which was recently shown to give rise to tree-level formulae for 4d gauge and gravity amplitudes with any amount of supersymmetry (including the case of no supersymmetry), and provide new insight into the relation between BMS symmetry and soft limits. I plan to generalize ambitwistor string calculations to loop level, curved backgrounds, and massive particles. Finally, another important direction is to understand the basic objects of M-theory, known as M2-branes and M5-branes. Although a great deal of progress has been made for M2-branes, formulating the M5-brane theory remains very challenging. Progress has recently been made in formulating non-abelian 2-form gauge fields on a Euclidean spacetime lattice. I plan to incorporate supersymmetry and self-duality into this construction, and compare it with supergravity in AdS4 x S7.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET HAMBURG;DE;;; 195669;658789;BIDAMARK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;BIg DAta-driven MARKeting for better competitiveness;1/06/2015;31/05/2017;;Big data analysis has become a source of competitive advantage for businesses and even whole economies. Big data is indeed a critical issue for the digital economy, innovation and services that are expected to drive growth and job creation in the EU. Compared to the USA, however, the EU has been slow in the adoption of big data analysis. Fortunately, big data opportunities still exist in many business sectors to improve the competitiveness of European firms. In particular, performance may be improved by making use of big customer data to offer goods and services that better meet customer needs, i.e., big data-driven marketing (BDM). However, adopting BDM has a steep learning curve due to organizations lack of understanding regarding the diverse factors required to succeed. The BIDAMARK project aims to assess the impact of different success factors on BDM, and consequently on firms ability to achieve superior customer performance. To answer this question, a comparative analysis between France- and US-based firms, and between industry sectors, will be implemented. A quantitative survey methodology will be applied with structural equation modelling (PLS) as the primary analysis method. This project is a perfect springboard for the Principal Investigator (PI) through the opportunity to build durable research networks, and acquire new skills that are complementary with his current expertise. New skills include research skills (theoretical and methodological), technical skills (use of new software tools), project management skills (lead of interdisciplinary project), language skills (French), and training skills (course teaching). Moreover, the publication of conference papers (later developed into high-impact journal articles) and recommendations for decision-makers will contribute to the improvement of the visibility of the PIs research, and positively influence his academic career. Finally, this project builds a foundation for future collaborations.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE TOULOUSE 1 CAPITOLE;FR;;; 195602;658391;NeutronOPV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New neutron techniques to probe bulk heterojunction solar cells with graded morphologies understanding the link between processing, nanostructure and device performance;1/07/2015;30/06/2017;;"This projects aim is to contribute to a better understanding of the relationship between processing conditions, active layer morphology and device performance in polymer solar cells (PSC), providing the understanding needed to guide the search for practical processing routes. The secondary aim is to develop new and more powerful characterisation techniques, to study PSCs, using neutrons in particular, and exploiting the potential of powerful and innovative new instruments at the neutron source ISIS, which is a partner on this proposal. These innovative new variants of neutron reflectivity, off-specular scattering and small angle scattering (SERGIS and SESANS), use spin-echo encoding to probe length-scales previously inaccessible by neutron techniques.
This work will focus on some of the most recently introduced and highest-efficiency polymers, such as PBDTTT-EFT, PTB7 and PCDTBT, creating thin films for devices both by the laboratory-based spin-coating method and also the industrially-scalable method of spray-coating. The methodology to be used will consist in processing the active layers from mixed solvents with step graded variations in composition, with the main purpose of generating a series of devices with graded variations in morphology. The as-produced active layers will be systematically investigated and compared in terms of morphology, charge mobility and photovoltaic performance; the neutron techniques available at the ISIS Neutron Spallation Source (Didcot, UK) will be complemented with a large suite of conventional laboratory-based techniques available at Sheffield University, and by x-ray scattering, both laboratory based and at synchrotron sources. This mixed solvent approach will be also valuable for scale up, especially by removing the need for halogenated solvents.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195509;657768;PEARS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Predicting the Evolution of Antibiotic Resistance in Streptococcus pneumoniae;1/06/2015;31/05/2017;;Streptococcus pneumoniae (the pneumococcus) is a bacterial species generally commensal to humans, but which occasionally causes infections responsible for the death of 800, 000 infants each year worldwide. Multiple genotypes exhibiting resistance to antibiotics have emerged in past years. Intriguingly, despite extensive antibiotic consumption operating strong selection for resistance, the latter remains at a stable frequency, 15% on average over the last 20 years in Europe. This is paradoxical, as robust coexistence of resistant and sensitive strains is unexpected under the simplest epidemiological models. In this project, I will investigate the possibility that coexistence is instead maintained by a more complex mechanism, relying on local adaptation to several niches characterized by different rates of antibiotic administration. I will develop a series of novel models with increasing realism and relevance to the context of S. pneumoniae, drawing from the often separate fields of population genetics and epidemiology. Starting with simple but general two- and multiple-niches models that allow for analytical solutions to provide initial insights, I will then build a more complex simulation model parameterized with biologically realistic contact and treatment structures. Output of this model will be confronted to large-scale patterns of spatial variation in resistance observed in epidemiological datasets. The analysis of these models will help us understand what factors facilitate the maintenance of coexistence in S. pneumoniae. This work may lead to better treatment policies to manage antibiotic resistance in this major pathogen.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195487;657685;CoordinGrowthDev;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of the mechanism of inter-organ communication coordinating tissue growth and developmental timing;1/03/2016;28/02/2018;;"Over the recent years, research in developmental biology has stumbled upon the problem of how development ensures that organisms achieve appropriate body and organ size. The coordination of organ growth with the developmental program is essential for the emergence of adults with proper body size and proportions. These species-specific features condition many traits of adult life such as fitness and survival. Studies on fruit flies have allowed setting up the conceptual frame for this research. Our current understanding is that tissue growth and the developmental program are synchronized by feedback control mechanisms that block the transition to the next developmental period until all tissues have completed growth.

Recent work in Drosophila has started unraveling the nature of the signals that couple tissue growth with developmental progression. A newly discovered Drosophila insulin-like peptide called Dilp8 is key in this coupling, raising the possibility that peptides with similar roles may exist in vertebrates. The current project aims at characterizing the molecular mechanisms by which Dilp8 coordinates development of the different body parts. First, I will conduct a biased genetic screen to identify the receptor for Dilp8. This will allow a better characterization of the biological functions of Dilp8. On one hand, I will unravel the target tissues of Dilp8 mediating regulation of steroid hormone and developmental transitions. On the other hand, I will investigate the role of Dilp8 signaling in coordinating growth among developing organs.

The project will shed light on the mechanisms of inter-organ communication that ensure the coordination of growth between tissues and with the developmental timing. The expertise of the host laboratory, combined the conceptual frame and experimental approaches of the project, will allow me to gain new skills and scientific knowledge, and to develop a successful research career in the field of growth control.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195492;657679;ZERO-TRAIN-BCI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Combining constrained based learning and transfer learning to facilitate Zero-training Brain-Computer Interfacing;1/04/2015;31/03/2017;;"Brain-Computer Interfaces (BCI) enable the user to control a computer or external device directly through his or her brain signals. This interface can be used for restoring communication for completely paralysed patients, to restore motor function through prostheses but also for non-medical applications such as gaming.
The initial BCI prototypes relied on voluntary modulation of the brain signals to control the computer. Nowadays, it is the computer that is taught via machine learning algorithms how to interpret the brain signals and this reduced the training times to 15-30 minutes for a calibration session. During such a calibration session, the user is instructed to perform specific mental tasks, such that the recorded brain signals can be labelled with the users intention. This labelled data-set is then used to train the machine learning algorithm. Unfortunately, due to non-stationarity in the observed brain signals, re-calibration is often required to ensure the accuracy of the interface. Obviously, frequent (re-)calibration is not desired. Especially for patients with a limited attention span, it must be reduced to a minimum.
The BCI community has invested much effort in reducing the need for calibration data. However, despite this effort, true zero-training BCIs that do not require calibration are rather rare. For the Event Related Potential (ERP) based BCI, we were able to develop such a true zero-training BCI based on the concepts of constraint based learning and transfer learning. That decoder was designed specifically for the ERP based BCI and cannot be ported directly to other paradigms. Hence, the goal in this project is to expand on this idea and to develop a true-zero training Motor Imagery (MI) based BCI by investigating novel machine learning methods based on constraint based learning and transfer learning.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET BERLIN;DE;;; 195549;658085;DAMAGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An avian model for understanding and preventing the negative effects of poor developmental conditions on subsequent health state, fertility and ageing rate;1/02/2016;31/01/2018;;"Poor developmental conditions have been shown to impact subsequent health, fertility and lifespan, both in human and animal models. However, the molecular, developmental and physiological mechanisms underlying these adverse effects on health later in life are still poorly understood. Since mammalian models do not allow manipulations of embryo development independently of maternal influence and nutritional state (i.e. without the mother potentially compensating for any manipulation), I will pioneer a new avian model using experimental controls of embryo growth and development through modulation of incubation temperature.

The key goals of this postdoctoral project are:

(i) To determine the extent to which developmental conditions (i.e. slow vs. fast embryo growth rate, developmental instability) induce deleterious effects on health, fertility and rate of ageing in later life.
(ii) To identify the molecular and/or physiological mediators of such adverse effects, by targeting parameters related to the ageing process (mitochondrial functioning, oxidative stress, telomere erosion and cellular stress resistance) and investigating the sparing of vital organs hypothesis.
(iii) To test both pre- and post-natal antioxidant therapies as preventive strategies to limit the deleterious impact of poor growth conditions on subsequent health, fertility and rate of ageing.

This project will use a novel approach to reveal completely new insights into the importance of developmental conditions for subsequent life-history trajectories and rates of ageing. It will also provide important insights for the poultry industry about the impact of developmental conditions and in ovo antioxidant supplementation on subsequent productivity and fertility.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 195440;657370;PATH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pathways to Heritage: Community heritage and the archaeology of movement in the Adelphi Forest, Cyprus;1/09/2016;31/08/2018;;"PATH is an exploration of heritage, viewed as an active process where the past is remade in the present. Even in the 21st century, archaeological projects impose research questions and methods onto rural landscapes while offering little to those communities who inhabit them. These communities, however, have their own interests, histories and needs, particularly when they face economic and social pressures like depopulation and a changing resource base. As in many such rural communities, the voices of the inhabitants of Nikitari, on the edge of the Adelphi State Forest in Cyprus, are absent from the national heritage, in spite of a nearby World Heritage site and a recent major archaeological project in the area. Why? PATH seeks to answer this question through focusing on the archaeology and heritage of Nikitaris pathways.
PATH builds on the Fellows research with indigenous communities in British Columbia, Canada, that used community-based participatory research (CBPR) methods to document the heritage value of a 19th century wagon road. This was part of a larger community initiative to reconnect people to their land and identity. PATHs innovation lies in its ability to transfer and adapt these methods to a new Mediterranean context to ask: what are the dynamics of heritage formation in Cyprus? Can giving voice to local heritage empower community members? PATHs legacy will extend to other rural settlements in Cyprus and Europe facing challenges of depopulation and under-development.
The Fellow will bring to the host organization a unique combination of extensive archaeological fieldwork experience in Cyprus and community-based research with a First Nations group in Canada. One of the greatest benefits of this fellowship will be mobilizing this expertise to develop a world-class knowledge base and advanced techniques for designing and facilitating CBPR projects on local heritage that can be applied across Europe.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 195439;657366;SPECIFIC fMRI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;From surrogate hemodynamics-based fMRI towards direct functional imaging of neural activity via sensing activity-induced cell swellings and neurotransmitter releases in vivo;1/04/2015;31/03/2017;;"Functional-Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function due to its ability to noninvasively tag active brain regions. Nevertheless, fMRI only detects neural activity indirectly, by relying on slow hemodynamic couplings whose relationships with underlying neural activity are not fully known.

We have recently pioneered two unique MR approaches: Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI and Relaxation Enhanced MR Spectroscopy (RE MRS). NOGSE-MRI is an exquisite microstructural probe, sensing cell sizes (l) with an unprecedented l^6 sensitivity (compared to l^2 in conventional approaches); RE MRS is a new spectral technique capable of recording metabolic signals with extraordinary fidelity at ultrahigh fields.

This proposal aims to harness these novel concepts for mapping neural activity directly, without relying on hemodynamics.

The specific objectives of this proposal are:
(1) Mapping neural activity via sensing cell swellings upon activity: we hypothesize that NOGSE-fMRI can robustly sense subtle changes in cellular microstructure upon neural firings and hence convey neural activity directly.
(2) Probing the nature of elicited activity via detection of neurotransmitter release: we posit that RE MRS is sufficiently sensitive to robustly detect changes in Glutamate and GABA signals upon activation.
(3) Investigating widespread neural circuits in vivo via stroboscopic optogenetics: we propose to couple NOGSE-fMRI with optogenetics to resolve casual dynamics in global neural circuitry.

Simulations for NOGSE-fMRI predict >4% signal changes upon subtle cell swellings; further, our in vivo RE MRS experiments have detected metabolites with SNR>50 in only 6 seconds. Hence, these two complementary and importantly, hemodynamics-independent approaches will represent a true paradigm shift: from indirect detection of neurovasculature couplings towards direct and noninvasive mapping of neural activity in vivo.";160635,6;160635,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD;PT;;; 195456;657497;SuSiPOD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Broadband Superconducting Nanowire Single Photon Detectors;1/07/2015;30/06/2017;;"Single-photon detection is an emerging technology, with applications ranging from medical imaging and LIDAR systems to space communication and fundamental quantum optics. Moreover, single-photon detectors are considered an enabling technology for the development of quantum information science, paving the way for the realization of one of the main challenges of the 21st century: the quantum computer. Currently, single-photon detection is carried out using semiconductor-based avalanche photodiodes; however, this technology is limited by large timing jitter, unavoidable dark counts, after pulsing, and limited detection efficiency. A recently proposed alternative relies on a superconducting nanowire biased just below its critical current, so that an impinging photon triggers a transition from the superconducting to the normal state, resulting in a voltage spike at the nanowire leads. The detection efficiency can be boosted close to unity by coupling the superconducting nanowire to the evanescent field propagating in a waveguide. However, the fabrication of high quality, ultra-thin superconducting layers is challenging, and the operation wavelength of such devices is limited by the waveguide band gap. We have identified GaN/AlN as the best suited waveguide material system, approximately lattice matched with NbN, and with a transparent band from 400 to 6000 nm. The target of the SuSiPOD project is the establishment of a technology platform for the fabrication of a new generation of broadband superconducting nanowire single-photon detectors built on III-nitride waveguides, in which photons are coupled laterally with the help of a tapered optical fibre. This new geometry should allow near-unity absorption probability in a wide spectral range, since the substrate is transparent to visible and infrared light. The project success will be proven by the realization of a working prototype which will greatly outperform state-of-the-art single-photon detectors.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;;; 195496;657712;BETAPEV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Beyond Empathy: Toward a phenomenological Ethics of Vulnerability;1/04/2015;31/03/2017;;According to a report, titled Violence against Women: an EU-wide survey and published by the European Union Agency for Fundamental Rights in March 2014, 'one in three women (33 %) has experienced physical and/or sexual violence since she was 15 years old, and, slightly more than half of all women in the EU (53 %) avoid certain situations or places, at least sometimes, for fear of being physically or sexually assaulted'. The report stresses that the feeling of vulnerability is prevalent among these women. Vulnerability is commonly defined as the ability to be harmed, and often associated with weakness or passivity. But the prevalence of the feeling of vulnerability among women in the European Union puts into question this framework and calls for a conceptual revaluation of this notion in order to address its ethical and social significance. This proposal aims to reconsider the moral and philosophical definition of vulnerability based on weakness and harm in order to elaborate a phenomenological ethics of vulnerability that goes beyond traditional accounts of empathy. To do so, the ontological framework of philosophical and psychological theories of empathy will be assessed. Political theories and development policies will be analyzed in order to offer solutions to prevent vulnerability from turning into violence and victimization. This proposal will rely on the phenomenological tradition to introduce the notion of vulnerable bodily self as a new paradigm to describe the individual. This research mixes theoretical analysis (phenomenology) and interdisciplinary empirical work (psychology, cognitive sciences, feminist theories). It bears significant consequences for contemporary philosophical discussions on the nature of the self. Its timeliness echoes a need for new theoretical paradigms to address political and social issues related to self-identity and peoples vulnerability in European societies.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195388;657087;NextGen RiBiomics;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Next Generation Proteomic Analysis of Pre-Ribosomal Proteome Dynamics Coupled to Glucose Metabolism in Caner Cells;1/04/2016;31/03/2018;;"The research field of proteomics proceeds rapidly thanks to recent technological advances of instrumentation, methodology, and software development. Next Generation Proteomics (NGP) refers to the integration of these three areas to provide a systematic approach for measuring proteome dynamics in both time and space during various cellular responses. In this proposal, I will analyze pre-ribosomal proteome dynamics in response to intracellular energy status using a NGP approach.
Specifically, I will determine how cancer cells regulate Ribosome Biogenesis (RiBi) to aid their survival under conditions of energy deprivation, which frequently occurs in connection with solid tumour development. The host laboratory is well known for developing and applying NGP strategies and will provide me with training and access to all of the equipment and resources required. To carry out this project I will first optimise methods for purification of human pre-ribosomal particles, combining my existing knowledge of RiBi with expertise from the Lamond group in nucleolar isolation. I will then use a quantitative proteomics approach to analyze pre-ribosomes isolated from cells grown under conditions of varied glucose deprivation. I will compare the components of pre-40S, pre-60S and pre-90S particles, respectively, using SILAC and the PepTracker software developed in the Lamond group. This project is based on my recent data showing that 47S pre-rRNA processing, which occurs in pre-90S particles, is suppressed by glucose deprivation in human adenocarcinoma HeLa and MCF7 cell lines. As the proteins contained in human pre-ribosomes are less well characterised than the corresponding yeast proteins, I will incorporate these results in a searchable database of human RiBi factors that will be freely available to the community. As RiBi is the most energy-consuming process in eukaryotic cell the results of this project may lead to novel cancer treatment strategies which target deregulation of RiBi.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Dundee;UK;;; 195462;657517;COLPHAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Collective Phenomena in dense Active Matter: phase transitions and non-equilibrium dynamics.;15/07/2015;14/07/2017;;The overall aim of the research activities presented in this proposal is to elucidate the general principles governing the physics of many-body systems of active particles when excluded-volume interactions compete with internal driving forces. We aim to reach a general understanding of this novel class of active materials and give an answer to the following question: How are the structure of the liquid and solid phases, and their mechanical response to an applied deformation, affected by self-propulsion? Statistical mechanics can efficiently deal with a broad class of soft matter systems at thermal equilibrium. However, active matter evolves in a non-equilibrium manner, as it is made of elements which have their own source of motion, which demands a new conceptual framework to describe it. By combining numerical simulations and theoretical analysis of model systems, we intend to get new quantitative predictions that can be tested experimentally in suspensions of self-propelled colloids, active emulsions or dense assemblies of cells, and exploit our results to design and characterise novel materials through collaboration with experimental groups. The completion of this programme will represent a major contribution into this fast-growing field with direct applications in materials science and biophysics: the engineering of synthetic materials that mimic the behaviour of living matter is a major challenge of current science and technology.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE BARCELONA;ES;;; 195495;657702;NEUROMITO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mitochondrial Dynamics and Local Protein Synthesis in Dendrites;1/01/2016;31/12/2017;;"Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schumans lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Research and Biophysics for mitochondrial proteomics and the advanced RNA sequencing techniques employed in the Schuman group for mitochondrial transcriptomics.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195708;659030;HEALTHYSYNAPSES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular mechanisms underlying synaptic maintenance and rejuvenation;1/03/2016;28/02/2018;;The deterioration of brain function and prevalence of dementias are some of the most striking and unfortunate consequences of ageing. Proper neuronal function relies on accurate signal transmission via synapses. While the basic cell biology of synaptic transmission is well studied, how precise activity is maintained over time remains poorly understood. Several age-dependent neurodegenerative conditions, characterized by the build-up of protein aggregates, affect synaptic function. These observations are consistent with a model where defects in the repair mechanisms that clear away defective proteins may constitute the basis for synaptic dysfunction and neurodegeneration. However, the processes that control protein rejuvenation at the synapse remain elusive. Autophagy is a process that is well suited for this purpose as it has emerged as a major means by which the cell can degrade dysfunctional components but a specific role for autophagy at the synapse has not been established. Levels in autophagy have been strongly linked to longevity and neuronal health. I hypothesize that autophagy plays an important role in synapse maintenance and that synaptic autophagy is disrupted during ageing and in neurodegenerative diseases. I will utilize a diverse set of approaches to elucidate the link between autophagy and changes in synaptic function during ageing in Drosophila. By generating novel optogenetic tools, I propose to test how the precise modulation of autophagy can influence synaptic function and whether boosting synaptic autophagy is beneficial in ageing and disease conditions. Furthermore, I will conduct a large-scale genetic screen for identifying genes regulating synaptic autophagy. Finally, I will explore the intriguing connections between synaptic proteins implicated in Parkinsons disease and autophagy. Revealing the mechanisms underlying synaptic maintenance and health will help guide strategies for alleviating the undesirable effects of ageing.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;VIB;BE;;; 195385;657054;NITRIDE-SRH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Energy losses in nitride light-emitting diodes;1/05/2015;31/01/2017;;"Light-emitting diodes (LEDs) are the future of lighting for general-purpose and industrial applications because of their potentially superior efficiencies. Group-III nitrides are the principal materials used to manufacture blue and green LEDs. However, they are still rather inefficient, despite a lot of research efforts. Increasing the efficiency and reducing the cost of LEDs is currently the question of paramount importance.

Nonradiative recombination at lattice defects is one of the main causes of reduced efficiencies. Direct experiments to determine the cause of nonradiative recombination are nearly impossible. This clearly calls for accurate theoretical modelling of nonradiative recombination in group-III nitride devices. A first-principles model will not only yield new knowledge about energy losses in nitride LEDs, but will also provide new insights into ways to improve device efficiencies. This is the main goal of the current Marie Sk?odowska-Curie project.

The researcher, dr. Audrius Alkauskas, will be returning to Europe after 3.5 years in the USA. He will be employed in the Centre for Physical Sciences and Technology (FTMC), under the supervision of prof. Gintaras Valu?is. During the project the researcher will become an independent group leader, and grow as a specialist in semiconductor physics via a close collaboration with his colleagues in Lithuania and abroad.";114432,15;114432,15;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS FIZINIU IR TECHNOLOGIJOS MOKSLU CENTRAS;LT;;; 195653;658793;CABBALA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;THE NAMES OF GOD AND OF CHRIST IN THE SYNCRETIC RENAISSANCE: MYSTICAL, MAGICAL AND VISUAL WORDS IN CHRISTIAN KABBALAH.;1/07/2016;30/06/2018;;The present research project aims at examining fresh material about the syncretistic tradition in the 15th and 16th centuries: it includes a wide range of theories by the so-called Christian Kabbalists about the different names of God and of Jesus in the context of Renaissance thought. The study will focus especially on the Christian Kabbalistic reading of the Tetragrammaton, the Pentagrammaton, and the Trigrammaton, i.e. the various names of God as expressions of new Christological interpretations to Jewish Kabbalistic doctrines. More specifically, this project intends to devote greater attention to the analysis of Renaissance syncretism in two ways: as a linguistic instrument and as a performative power. The analysis will be examined through the writings of Giovanni Pico della Mirandola, Johannes Reuchlin, Giles of Viterbo, Niccol Camerario, Francesco Zorzi and Arcangelo da Borgonovo. This research will also consider some unknown Jewish sources that influenced, either explicitly or implicitly, the Christian Kabbalistic theory of the divine names. Our purpose is therefore to answer the question of facing theological otherness in the Renaissance through a new type of cultural synthesis. In some way, combining Abrahamic faith with Kabbalah, Hermeticism and Trinitarian creeds, results in overcoming the conflicts of dogmas in order to converge towards a unified plurality of traditions. Starting with the hypothesis of a Kabbalistic metamorphosis of humanistic theology in the Renaissance, we hope that the proposed research will demonstrate that the Christian theories on Jewish divine names, against the background of Kabbalah and barbarous wisdom, was impossible without transgressing sacred boundaries and creating new values. Accordingly the work of many Christian Kabbalists should be reintegrated into the european heritage as the first stage of a cultural change, where a comparative frame of mind is essential for the sake of interreligious dialogue.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195587;658327;2D Hetero-architecture;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Engineered two-dimensional hetero-architectures for nanoelectronics;24/03/2016;23/03/2018;;Graphene a single layer of carbon atoms exhibits a unique combination of superior properties, which makes it a credible starting point for new disruptive technologies in a wide range of fields. However, the absence of an energy gap in its electronic band structure prevents at present its integration in digital logic devices. This research project will tackle the challenge by incorporating nanometer-size boron nitride or boron carbon nitride barriers in graphene domains. These lateral hetero-structures will be used as channel elements in field-effect transistors, whose electron transport properties will be evaluated by a combination of high- and low-temperature electrical measurements. The synthesis of the hetero-structures will be extensively investigated through optical, electronic, probe microscopy and spectroscopy analyses. This approach is designed to take a holistic view of the synthesis process, not only hunting for the highest apparent quality of the grown nano-structures, but also gaining an understanding of the underlying atomistic growth mechanism, so as to enble engineering of these structures.The project will advance European scientific competitiveness in the field of synthesis of 2D hetero-structures, currently a prerogative of a select few US groups, and will provide new platforms which might represent a viable option to obtain graphene-based transistors suitable for digital logic.The multidisciplinary aspect of the project will allow me as experienced researcher to gather knowledge in topics as different as synthesis of nanomaterials, electronic device manufacturing, and low-temperature electrical characterization. It will also allow me to re-integrate the European scientific network, after my postdoc experience in the US, forming a perfect basis of my goal of establishing an independent research group in a European university.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DANMARKS TEKNISKE UNIVERSITET;DK;;; 195494;657701;LiVirIn;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;3D Liver Organoids: Modelling Host Hepatitis B Virus Interaction;1/03/2015;28/02/2017;;"An estimated ~400 million people are chronically infected with hepatitis B virus (HBV) infection worldwide, resulting in an estimated $658 million in medical costs and lost wages annually. Although HBV disease can be prevented by vaccination, many people still become infected. Potent and safe drugs are available to eradicate HBV viral particles and clinically cure HBV infection. However, during replication HBV delivers a very stable form of viral DNA (covalently closed circular DNA, cccDNA) in the nucleus of the hepatocyte, causing life-long risk of reactivation of HBV infection in case of suppression of the immune system (e.g. chemotherapy). Therefore the pharmaceutical industry is now aiming to develop strategies to eradicate the virus from the infected liver completely. Such studies are hampered by the lack of appropriate in vitro or animal models due to the narrow tropism of HBV for human hepatocytes. The hypothesis of the project is that creation of 3D culture systems encompassing hepatocytes, hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) derived from an inexhaustible source of cells (human pluripotent stem cells (PSCs)) in a matrix that mimics the biophysical and biochemical features of the liver, will be a superior model for the study of HBV infection and evaluation of the efficacy of antiviral drugs. We also hypothesize that such 3D organoids will improve maturation and function of hepatocytes, HSCs and LSECs.
The proposed studies are highly interdisciplinary, merging expertise from biology, to biophysics and engineering, with inter-sector mobility, networking, collaboration and knowledge transfer between academia and industries. The knowledge developed will be disseminated by presentations at consortium meetings, international conferences and in peer publications. All these aspects will train the researcher as independent thinker, more knowledgeable in scientific research which will provide an enormous boost to his carrier.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 195472;657592;SECOMAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sexual Commitment of Malaria Parasites: Investigation Into the Epigenetic Control of Plasmodium Gametocytogenesis;1/08/2015;31/07/2017;;"Malaria is one of the major threats for human health worldwide and caused by unicellular organisms of the Plasmodium genus. Within their mosquito vector and human host malaria parasites replicate almost exclusively asexually. In order to be transmitted to mosquitoes formerly asexual parasites instead develop into gametocytes, which are the only forms that can infect mosquitoes. Understanding the switch of asexual to sexual replication could offer new routes towards therapeutic intervention in sexual development and transmission. However, the molecular details of commitment to gametocytogenesis remain largely unknown, and only recently the AP2-G transcription factor was identified as master regulator of gametocytogenesis.
Gametocyte formation is a dead end for enduring infection and therefore sexual commitment has to be suitably regulated to ensure prolonged infection and transmission at the same time. The proposed research project aims to elucidate the epigenetic mechanisms which controls gametocytogenesis in malaria parasites infectious to rodents and humans, and intends to identify key molecular factors which regulate repression and activation of the ap2-g locus. The project will shed new light on the molecular mechanisms controlling sexual commitment and general gene expression in Plasmodium, with implications for therapeutic intervention in transmission and development of malaria parasites.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 195476;657605;Intentions in Action;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Intentions in Action: Establishing the neural causes of intentional action;1/08/2015;31/07/2017;;"The neuroscientific study of intentional action has produced puzzling and contradictory results: intentions show up at a variety of brain locations, and up to ten seconds before a decision has been made. Recently, it has been argued that intentions do not underlie voluntary action at all. At the same time neural states have been found that could be correlated with future actions, suggesting a role for intentions after all. The proposed project suggests that the cause of these seemingly contrasting results lies in the heterogeneous composition of everyday actions, consisting of both immediate and future-directed components. The proposed research promises to go to the bottom of this controversy by investigation what types of actions can be accomplished without discrete states like intentions, and for what types of actions intentions are needed. It will do so by looking for common factors in brain states underlying actions using functional Magnetic Resonance Imaging. Particularly, it will be investigated whether similarity in motor acts, actions, or contexts are crucial for finding commonalities in brain states.
Next, it will be investigated whether immediate actions and future actions differ with respect to the neural control processes, thereby directly testing the applicability of a philosophical distinction to neuroscientific research.

Finally, it will be assessed whether these processes are unique for self-chosen actions, or also apply to cued actions as well. This will relate the study of intentional action directly to adjacent scientific fields studying prospective memory and task sets.

By solving these issues the proposed research sets out to create a novel and detailed account of intentional action which will function as a framework for future research in philosophy, psychology, and neuroscience.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Charit Universittsmedizin Berlin;DE;;; 195424;657272;COFFEE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Condensed-phase Optical-Femtosecond-Fringe-Encoded EUV Diffraction;1/04/2015;31/03/2017;;"As can be seen in the history of science, new techniques and methods open new research fields. In this project, the authors propose to use a new methodology approach to study thin layers of condensed matter and surfaces. We aim to perform Attosecond Transient Absorption Spectroscopy combined with femtosecond Transient Grating to study ultrafast time evolution of a model sample solid krypton.

We identify our major objectives as work packages:
WP1: Attosecond XUV Transient Absorption Spectroscopy of gaseous krypton.
WP2: Attosecond XUV Transient Absorption Spectroscopy in the condensed phase, the example of solid krypton.
WP3: Condensed phase Transient Grating spectroscopy in the XUV spectral range with attosecond resolution.

All experiments will be performed by O. Hort PhD within the Ultrafast Laser Group led by Prof. A. Baltu?ka (Photonics Institute, the Vienna University of Technology, Austria).";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET WIEN;AT;;; 195441;657374;DROUGHTROOT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Plants in search of water: physiological and molecular interplay between root hydraulics and architecture during drought stress;15/03/2016;14/03/2018;;Plants have to constantly adjust their water status during development and in response to very changing environmental conditions, recently increased by climate change. By exploring the soil and taking up water, plant roots play a crucial role in these processes. Drought exerts deep effects on root functions by altering root cell water permeability (hydraulics) and modulating the growth and architecture of the root system. Water channel proteins named aquaporins adjust root hydraulics in response to many stimuli, including drought stress. Auxin plays, together with abscisic acid (ABA), a pivotal role in root growth and development and regulates aquaporins during lateral root formation (LRF). The present project proposes a frame for integrating these effects by exploring functional links between root architecture, aquaporins and hydraulics, phytohormones, and modelling. Responses to water stress will be studied from the elementary level of LRF up to the whole root level to identify complex interactions and signalling pathways. The Arabidopsis root was chosen as a model for accelerated discovery, as it allows a unique combination of developmental biology, genomics, biophysics and mathematical modelling, with the purpose to transfer this knowledge to crops. This novel and multidisciplinary project will be carried out by a researcher with a strong scientific expertise on agriculture and plant molecular physiology which perfectly matches the proposed project. The latter will be implemented within a consolidated group and an internationally recognized institution (Aquaporin team, BPMP, CNRS/INRA/SupAgro/UM2 Montpellier, France). This combination provides a unique scientific platform for the research training of the applicant and the development of frontline research in plant science. The overall project will be strongly beneficial for the development of the applicants independent research career and will definitely strengthen his scientific profile.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195533;657982;Cheap-GSHPs;SIGNED;"H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-03-2014;H2020;CHEAP AND EFFICIENT APPLICATION OF RELIABLE GROUND SOURCE HEAT EXCHANGERS AND PUMPS;1/06/2015;31/05/2019;;To reduce the total cost of low enthalpy geothermal systems by 20-30 % the project will improve actual drilling/installation technologies and designs of Ground Source Heat Exchangers (GSHEs). This will be combined with an holistic approach for optimum selection, design and implementation of complete systems across different underground and climate conditions. The proposal will focus on one hand on the development of more efficient and safe shallow geothermal systems and the reduction of the installation costs. This will be realized by improving drastically an existing, innovative vertical borehole installation technology of coaxial steel GSHE and by developing a helix type GSHE with a new, innovative installation methodology. These GSHEs will be installed to a depth of 40 50 meters ensuring improved safety and faster permitting. On the other hand, the proposal will develop a decision support (DSS) and other design tools covering the geological aspects, feasibility and economic evaluations based on different plant set-up options, selection, design, installation, commissioning and operation of low enthalpy geothermal systems . These tools will be made publicly available on the web to users, including comprehensive training to lower the market entry threshold. Given that drilling and GSHE technologies are mature but costly, this holistic approach is included in the proposal to bring the overall cost of the total project down, i.e. not just the cost of the GSHE itself but the avoidance of ground response tests, the engineering costs for the design of the GSHE and the integration of heat pumps with building heating and cooling systems. Also the use of novel the heat pumps for higher temperatures developed within the project will reduce the costs in the market for retrofitting buildings. The developments will be demonstrated in six sites with different undergrounds in different climates whilst the tools will be applied to several virtual demo cases.;5804847,5;4844652;H2020-LCE-2014-2;IA;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;"SOCIETATEA ROMANA GEOEXCHANGE;Friedrich-Alexander University (FAU) Erlangen-Nrnberg;GEO GREEN;CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;GALLETTI BELGIUM;REHAU AG+CO;FUNDACION TECNALIA RESEARCH & INNOVATION;UNIVERSITA DEGLI STUDI DI PADOVA;ENERGESIS GROUP SL;ANER SISTEMAS INFORMATICOS SL;PIETRE EDIL SRL;HYDRA SRL;SLR ENVIRONMENTAL CONSULTING(IRELAND)LIMITED;SCUOLA UNIVERSITARIA PROFESSIONALE DELLA SVIZZERA ITALIANA (SUPSI);UNITED NATIONS EDUCATIONAL, SCIENTIFIC AND CULTURAL ORGANIZATION -UNESCO;R.E.D. SRL";"RO;DE;BE;EL;ES;IT;IE;CH;FR"; 195481;657637;FOODWASTE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Food Waste In Denmark and Sweden - Understanding Household Consumption Practices to develop Sustainable Food Care;1/04/2016;31/03/2018;;"Globally, a startling amount of food is being wasted. This is costly in financial and environmental terms. Much of this wasting occurs in the trajectory from farm to shelf. However consumers, especially those living in wealthier regions of the world, also throw away considerable amounts of food. Based on the alarming numbers reported in statistical research on food waste, campaigns and public policy is being developed to change consumer behaviour. However, much of current food waste research, campaigning and policy is not based on any actual knowledge of what consumers do. How do ordinary consumers actually go about buying and then using and/or wasting food? Which daily life tinkering techniques have they invented? And how do societal and technological infrastructures enable or disable food waste avoidance?
The present research project will study how consumers handle their food. Mixed methods will be used to comparatively study online anti-wasting campaigns/communities and household practices in two Danish and two Swedish cities. In the process current understandings of food waste will be challenged by: (1) combining a focus on wasting practices and 2) understanding the perishable nature of food; (3) highlighting the techniques that consumers use to avoid wasting by caring for it; and (4) exploring how people balance sustainable food care with other hopes and daily life demands.
By fleshing out the concepts of timing, caring and negotiating the project will develop an original theoretical repertoire for understanding food wasting. The results of the action will allow me to contribute to further strengthening already existing food research at the SAXO Institute, University of Copenhagen (UCPH). It will also enrich our knowledge and be valuable for (a) further development of sustainable policies and actions directed against food wasting within the EU; (b) retailers, consumers and others who handle foof;and (c) other academics researching food and/or wasting.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195447;657441;EcoDA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Experimental co-Design Approaches: Investigating possibilities for creating networks of resilient citizens and civic actions of urban resilience through hybrid platforms;1/10/2015;30/09/2017;;"EcoDA investigates methods for co-designing platforms that can stimulate collective civic actions of urban resilience and enhance the capacities of urban residents to become resilient. The project focuses on food practices as case studies of resilient actions and tests a hybrid platform in three European cities London, Paris and Bucharest. The research has three main objectives: 1) to examine the social, cultural, political and technological contexts for urban resilience, and map existing civic initiatives around resilient food practices in the three selected cities; 2) to co-design, prototype, test and refine open source digital platforms that could enable such civic initiatives to take place and/or expand, and enhance resilience capacities for citizens; and 3) to evaluate the capacity of these co-designed platforms to generate forms of public participation and urban governance that can stimulate actions of urban resilience. To address these objectives, the research will be carried out through design practice, through secondments within three professional practices working in the area of urban resilience, in the three elected cities. The methodology includes traditional qualitative methods (e.g., interviews), participatory action research, co-design experiments and collaborative workshops. The innovative and original aspects of EcoDA offer significant value in the context of the Horizon 2020 EU Programme, by addressing areas of special focus (e.g., sustainable food security and waste management) and key objectives (e.g. boosting industry engagement and supporting innovation). Moreover, the practice-based research approach, the open-source nature of the platform and the provision of the metadata needed to enable the platform, will facilitate the up-scaling and up-taking of EcoDAs outcomes in various cities across Europe and possibly further away, thus enabling collaborations beyond the term of the project.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195373;656998;REE Value Chain;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rare Earth Supply Chain and Industrial Ecosystem: A Material Flow Assessment of European Union;1/10/2015;30/09/2017;;"Europe is the leading importer and consumer of rare earth minerals both in mineral and applied forms. Europe is almost dependent on others for imports of these mineral resources, despite the fact that engineering and manufacturing are backbone of many European economies. The criticality of these minerals were highlighted in European Commissions Report of the Ad hoc Working Group on defining critical raw materials published in 2010 as well as 2014.
E.Us primary end use application of REEs includes polishing, metal alloys, magnets, and catalysts. Highest demand growth is foreseen in high tech-electric/hybrid vehicle motors, magnets, phosphors and ceramics end-markets. Though these raw materials are fundamental to Europes economy, growth and jobs, the importance of these minerals to European economy has never been studied thoroughly. However, responses have been initiated in different nations, economic areas and companies, with the European Commission launching the Raw Materials Initiative (RMI).
European Commission has identified criticality of raw materials to boost the innovation capacity of the EU along with addressing entire raw materials value chain in the Raw materials part of the Societal Challenge 5 of Horizon 2020. Therefore an empirical study on rare metals including rare earth elements and its importance to European economy in terms total demand, the issue of stable supply, recycling capacity of European companies, value addition and value chain management become important aspects to study and applying an input-output matrix and network diagram, the study will trace the entire value chain of the identified minerals from mining to intermediate products to final products and calculate the value addition in each stage";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT LEIDEN;NL;;; 195457;657501;InVivo_DDR_ADPR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Decoding the DNA damage signalling in C. elegans by proteomic analyses of ADP-ribosylation;1/04/2016;31/03/2018;;Preservation of genome integrity and stability is critical for survival and propagation of individuals and species. Organisms have thus evolved rapid and efficient mechanisms -collectively termed the DNA damage response (DDR)- to combat threats posed by DNA damage. Among these, the post-translational modification (PTM) ADP-ribosylation (ADPR) plays a decisive role in effective DDR. Although much is known about the relevance of ADPR upon DNA injury, the underlying molecular mechanisms are still poorly understood and no systematic, unbiased proteome-wide study to determine ADPR targets in vivo has been conducted to date. The most challenging and innovative goal of this proposal is to profile in vivo ADP-ribosylated peptides during DDR in the well-established model system Caenorhabditis elegans by the combined application of advanced proteomic approaches. I will develop novel enrichment strategies that will allow me to confidently map for the first time all the sites of ADPR throughout the C. elegans proteome. I will take advantage of SILAN technology, which allows stable isotope labelling in C. elegans, to determine the quantitative profiles of thousands of ADPR sites during DDR. By bioinformatic analysis, I will select candidate proteins for further investigation of the biological role of DNA damage-induced ADPR. I will then test the biological impact of ADPR of these candidates through site-specific mutation of their identified modification sites. Finally, I will perform biochemical, molecular and functional experiments to study how ADPR alters the activity of these proteins and thereby characterize the mode of ADPR action. Understanding the regulatory networks that underlie such a complex biological process at the organism level will provide new insights for improved treatment of DNA damage-related diseases including cancer. This is an ambitious, innovative, cross-disciplinary project at the forefront of two exciting fields, biology and proteomics.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195461;657514;DECOS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unrestricted Divide-Expand-Consolidate Coupled Cluster Methods for Large Open-Shell Molecules;1/04/2015;31/03/2017;;"Computational chemistry is a modern and multidisciplinary subject, which underpins many areas of chemistry, physics, biology and material science. Due to recent advances in both theory and computational facilities, it is now quite clear that computational chemistry has reached the point where it should be considered as an equal partner to experiment and that in some cases it may even guide and unite the experimental efforts across multiple scientific disciplines.
The proposed DECOS project (Unrestricted Divide-Expand-Consolidate Coupled Cluster Methods for Large Open-Shell Molecules), addresses one of the most challenging problems of contemporary computational chemistry: the ability of theoretical modeling to describe accurately large open-shell systems (molecules with one or more unpaired electrons) at affordable computational costs. To this end the Divide-Expand-Consolidate (DEC) scheme must be extended to unrestricted formalism. The new method constitutes crucial breakthrough because it combines linear scaling and rigorous error control of the established DEC scheme with the ability of treating large open-shell systems for biological and industrial use. Indeed, magnetic and catalytic properties, reactivity and spectroscopy often must be entirely attributed to special electronic structure of the open-shell systems. Additionally, through collaboration with Oak Ridge National Laboratory, the new methods will be implemented, tested and run on TITAN one of the largest super computers in the world.
Besides cutting edge science proposed in the project, it will also become a crucial step towards reaching professional maturity and independence in the applicants career. The project has potential for creating broad scientific impact and to establish long-term collaborations. Also, it assures the new knowledge will be secured, transferred and applied fully. The proposed developments will likewise be used and maintained for many years beyond the lifetime of the grant.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 195425;657283;MASIEGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multilateral adverse selection in industrial economics and general equilibrium;1/09/2015;28/02/2017;;"It is aimed to understand the economic consequences of multilateral private information, and to obtain corresponding policy implications. The focus will be on two types of contexts: (i) oligopolistic firms seeking to constitute a collusive agreement, having private information about their costs and/or the quality of their products; (ii) agents trading in an otherwise perfectly competitive environment, having private information about their preferences and/or the quality of the products that they bring to the market. In the presence of multilateral adverse selection, a small number of firms may not be able to reach a cooperative agreement to divide the market if a firm's willingness to cooperate is interpreted as a sign of weakness by the other firms. Knowing that the other firms are willing to cooperate and, therefore, are relatively weak, if a firm is still willing to cooperate, this reveals its weakness to an even greater extent. As a result of such a cascade, firms may never be able to establish a cooperative agreement. In an otherwise perfectly competitive environment plagued by adverse selection, if an agent purchases a good that he/she cannot distinguish from other goods, the agent should receive the good that is the cheapest among those that he/she cannot distinguish from the purchased good. General equilibrium analysis of such economic contexts can be made possible by using an analytical trick of distinguishing goods not only by their physical characteristics but also by the agent that brings them to the market. The novel insights generated from these investigations, and the understanding of their scope of validity, matter to competition policy in oligopolistic and approximately competitive industries. They can also be used as building blocks for further research. In particular, general equilibrium results should be amenable of application to macroeconomic modelling and policy design.";138807;138807;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDATION JEAN-JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES;FR;;; 195638;658676;VECTORIGAMI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;DNA Origami for drug delivery;1/06/2015;31/05/2017;;"The main objective of this project is to produce innovative DNA self-assembled nanostructures with the goal of evolving new approaches for drug delivery. The properties of the DNA nanostructures will be tuned by introducing new elements into the nanostructures improving their versatility and structural integrity. This project will aim to:
build and characterise DNA nanostructures using long oligonucleotides of biological production;
add different elements to the nanostructures, such as gold nanoparticles and proteins to the nanostructures to tune the respective intrinsic and structural properties;
develop new strategies to simplify the assessment of the integrity of nanostructures using fluorophores;
apply the newly developed nanostructures to assemble a delivery system for doxorubicin.

This project will result in a synergy between the applicants particular profile and the high quality of the host institution. The applicant has experience in different sets of scientific areas such as fluorescence and nanotechnology as well as a background in molecular and cell biology. Complementarily, the host institution, the Department of Neuroscience at Karolinska Institutet, and Bjrn Hgbergs laboratory in particular, will provide the necessary knowledge on DNA nanotechnology. Hgbergs group has recently established itself as one of the leading DNA-nanotechnology labs in Europe with high-impact publications in the field.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KAROLINSKA INSTITUTET;SE;;; 195479;657630;TDL2Ho;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Thin-disk lasers for the 2-micron spectral range based on Ho-doped monoclinic double-tungstate epitaxial structures;1/06/2015;31/05/2017;;The research activities planned will be devoted to development, test and characterization of novel thin-disk structures based on epitaxially grown monoclinic double tungstate crystals for use in high average /peak power all-solid-state laser systems operating in the important 2-m spectral range. Laser gain will rely on the Holmium (Ho) trivalent ion which is potentially very suitable for high energy due to its advantageous spectroscopic features. The latter allow one to excite it directly into the upper laser level, producing less heat and enabling power scaling with diode pumping. Moreover, wavelengths slightly above 2 m, emitted from such tunable Ho-lasers, are attractive for various applications.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FORSCHUNGSVERBUND BERLIN E.V.;DE;;; 195480;657633;DecipherBILU;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding functional mechanisms leading to the BILU syndrome;1/05/2015;30/04/2017;;The BILU syndrome is an autosomal dominant primary immunodeficiency that combines B cells Immunodeficiency, Limb abnormalities and Urogenital malformations. Recently, we discovered the genetic basis of this disorder using whole exome sequencing. The causative mutation affects the protein that is involved in mediating transcriptional responses after activation of nuclear receptors (e.g. sex hormone receptors). Altered signalling via nuclear receptors is likely to impact a wide range of genes implicated in development, homeostasis and metabolism leading to the BILU syndrome. In this proposal, we develop a strategy to characterize the impact of the newly discovered mutation on nuclear receptor signalling. We will use analysis of patients primary fibroblasts, induced pluripotent stem (iPS) cells and CRISPR-Cas9 edited cell lines to investigate how the mutation impacts transcriptional responses after hormonal stimulations. This project will give insights in the function of the newly identified protein that is involved in the BILU syndrome and will help to understand its broader role in regulation of gene transcription.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195370;656994;nanoCAVa;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Formation of nano-scale clusters from atmospheric vapors;1/08/2015;31/07/2018;;This research concentrates on advancing the understanding of the border between the gas and condensed phase by studying the formation of nanoscale clusters from atmospheric vapours (NanoCAVa). Cluster formation and growth is a crucial step in forming new aerosol particles in the atmosphere. We aim to resolve the role of molecular clusters in aerosol formation by targeted field measurements at various locations and precisely controlled chamber experiments. Using and further developing the latest measurement technology, and combining physical and chemical information, enables us to get a full characterization of neutral clusters, which is so far lacking. We utilize the results to create a better description of the dynamics of 1 5 nm nano-particles, which often cannot be treated with traditional theories, and to implement the concept of a cluster mode into the general view on the atmospheric aerosol size distribution. Understanding the factors controlling the growth of newly formed clusters into climatically relevant particles and cloud condensation nuclei (CCN) enables estimating their importance in the climate system more accurately. This project will facilitate the ER to pursue a successful research career in atmospheric science and establish her position as an expert of nano-particle measurement technology. It will also strengthen the role of the beneficiary and the partner organization as the leading groups in atmospheric nucleation research and their mutual collaboration.;265082,4;265082,4;H2020-MSCA-IF-2014;MSCA-IF-GF;HELSINGIN YLIOPISTO;FI;;; 195572;658244;PEMETH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Planning and Evaluation Methodologies for Mental Healthcare Buildings;1/06/2015;31/05/2017;;The study of psychiatric facilities is major for the care of vulnerable people. It is central to the study of therapeutic environment for mental health, great value for understanding mental illness and the psychosocial impact of the built environment and formulating interdisciplinary relations between architecture and health. In Europe, about 20% of the burden of disease relates to mental illness. With low diagnostic and low medical treatment accuracy factor, environment is key for quality of care and patients social re-integration. The key questions of this proposal are: (i) how the mechanisms of the environment influence the personal and social milieu of psychiatric space, and (ii) how the environmental needs of the mentally ill are met by wards. Work in other healthcare settings has shed some light on the first, yet little is known about the second. For these, the researcher aims to exploit the scientific tools of architectural morphology (Space Syntax) and juxtapose them with a patient-focused, model for the evaluation of psychiatric environment (the SCP model), to investigate environment in an integrated way. The research will be comparative of two methodologies and will involve facilities in the community as case studies for its physical locus. Those will be examined for their spatial qualities. The findings could set the framework for a model for evidence-based healthcare architecture to serve as design and evaluation tool, immediately accessible to architects and stakeholders. The final product will be design methods and guidelines for healthcare architecture and in particular for community psychiatric facilities immediately accessible to architects. The research is expandable, when environment is important in prevention and care strengthening the area between healthcare from one side and architecture on the other. However, the largest contribution is in architecture, a sector of great potential, yet in need of more interdisciplinary connections.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195409;657215;OUTstandINg;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies;1/09/2015;31/08/2017;;"The MSC OUTstandINg project will use bioorthogonal click chemistry as tool to covalently attach magnetic nanoparticles (MNPs) to living cell surfaces with the aim to address two fundamental questions in the field of magnetic hyperthermia therapy using MNPs: 1) how the subcellular localization (on the plasma membrane or inside the cells) of MNPs affects their heating behaviour when compared to MNPs in solution 2) how MNPs immobilization and sub-lethal magnetic hyperthermia impact different subcellular signalling pathways and the biophysics of cell membranes.
OUTstandINg is a multidisciplinary two-years research project built upon the expertise of the Fellow (Dr. Raluca M. Fratila) in bioorganic chemistry (including click chemistry, bioconjugates and functionalization of surfaces and (nano)materials) and the experience of the supervisor (Dr. Jess Martnez de la Fuente) and of the host group (GN2 - Nanotherapy and Nanobiosensors, University of Zaragoza, Spain) in nanotechnology and nanomedicine. This MSC action will offer the Fellow the possibility to work in one of the top European institutions in nanoscience, where she will further develop her skills and will acquire new skills and knowledge necessary for the progress of her scientific career towards an independent position. The secondment period at University College London Institute for Biomedical Engineering (supervisor Prof. Quentin Pankhurst) will reinforce and complete the multidisciplinary training-through-research. The project will generate important knowledge and collaborations in the European Research Area (ERA) and will contribute to enhance the excellence of ERA through cutting-edge research at the frontier of chemistry, physics, materials science, cell biology and nanotechnology.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE ZARAGOZA;ES;;; 195519;657875;SCARtool;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Scattered radiation reduction tool to improve computer-aided diagnosis performance in digital breast tomosynthesis;1/09/2015;31/08/2017;;"Breast cancer is the most common cancer diagnosed in women worldwide. This has motivated the establishment of breast screening (BSPs). X-ray mammography is the current gold standard technique in BSPs for early breast cancer detection. However, this technique suffers from performance limitations due to tissue superposition which can either mimic or obscure malignant pathology. For this reason digital breast tomosynthesis (DBT) is currently being investigated.
DBT consists of a series of projected images of the breast with potential to overcome the aforementioned limitations. However, DBT shows high levels of scattered radiation within the image receptor which can reduce significantly the visibility of breast lesions and the lesion detection performance of computer-aided diagnosis (CAD) systems. CAD systems are frequently used in BSPs to provide useful information to radiologist regarding breast lesion location and characterisation, thus CADs performance is critical to achieve acceptable breast cancer diagnosis rates.
The aim of this fellowship is to develop a novel tool to reduce scattered radiation directly from clinically acquired DBT projections. These scatter-reduced images will be incorporated, for the first time, into a new DBT CAD system to significantly improve the detection of subtle lesions as microcalcification clusters (MCC). The scatter reduction will be achieved after adapting an existing convolution-based algorithm for synthetic DTB images to work with clinically acquired DBT images. The CAD experience of ViCOROB and the DBT experts support from UDIAT guarantee the success of this project as well as the correct transfer of knowledge from the lab to the clinical site. The proposed tool will enable radiologists to detect more accurately breast lesions and therefore reduce the mortality in breast cancer patients. It is also planned to commercialise the output CAD tool to clinical sites through existing medical imaging companies or via a spin-off.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE GIRONA;ES;;; 195466;657536;SNBinaries;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Close binary progenitors and ejected donor remnants of supernovae type Ia;1/11/2015;31/10/2017;;"The properties of dark energy are basically unknown, despite the fact that it largely dominates the energy budget of the Universe. Deriving those properties is therefore one of the key unsolved problems in modern astronomy. The analysis of supernovae type Ia (SN Ia), which are regarded as cosmological standard candles, is widely used as a tool to achieve that goal. Large surveys are and will be conducted to reduce statistical errors and help to understand systematic uncertainties. However, the progenitors of SN Ia explosions are still unknown and this introduces systematic uncertainties in the use of SN Ia as standard candles. To correct for this crucial systematic effect it is not only necessary to unambiguously identify the progenitor population, but also to characterize its fundamental properties as detailed as possible.
Recently, close, eclipsing binaries consisting of white dwarfs and compact helium stars have been identified as important progenitor candidates. The helium star companions are ejected after the SN Ia explosion with the most extreme velocities known in our Galaxy. This so-called helium double-detonation scenario therefore provides the unique opportunity to study both the progenitor sample and the sample of the ejected companions in detail. During this Marie Curie fellowship we want to use public data of time-domain surveys (e.g. GALEX gPhoton, SuperWASP, PanSTARRS) to identify the progenitors and ejected companions. Based on photometric and spectroscopic analyses, we want to characterise representative samples of them. These fundamental samples can be used in the future to reconstruct the formation and evolution of the progenitor systems. Modelling this formation and evolution for the early Universe and comparing it to the local sample will uncover the intrinsic differences between SN Ia for different ages of the Universe, which cause the systematic effects when using SN Ia as cosmic distance indicators.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195358;656918;MEPOL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of plant primary and secondary metabolism in pollination;9/06/2015;8/06/2017;;Pollination contributes to more than $200 billion of revenue, about 10% of the global agricultural production. In addition to higher yields and better quality of fruits and vegetables, pollination has evolutionary implications. Understanding the cues that attract and sustain pollinators will positively impact agriculture and our knowledge on how to preserve biodiversity. This project aims to unravel the role of plant metabolism in pollination by exploiting the genotypic variation existing among natural accessions of Arabidopsis and in combination with metabolomics and transcriptomics to identify genes that regulate the traits that plants use to attract and reward pollinators. These are fragrance, colour and nectar. Volatiles emitted from flowers of a collection of 360 Arabidopsis ecotypes will be analysed via GC-MS, and sugars, amino acids and secondary metabolites measured via HPLC and LC-MS. Genome-wide association studies will be used to correlate metabolic phenotypes and single nucleotide polymorphisms to loci that regulate pollination traits, which will be further studied to establish gene functions. Metabolites and RNA extracted at time points during flower development will be used to identify the regulatory elements of pollination-related metabolite formation. To assess the contribution of pollination traits to flower attractiveness, behavioural experiments with hoverflies will be performed. Finally, the knowledge acquired from the model plant Arabidopsis will be transferred to the oilseed crop Camelina, in which pollination efficiency will be measured as seed production. The project combines multidisciplinary approaches to expand the skills of the fellow. In turn, the fellow will bring expertise about Camelina and CRISPR to the host. At its completion, the project will provide the host institution with a large dataset of metabolic signatures for the generation and validation of new hypotheses with regard to scent, colour and nectar formation.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195693;658974;Helping in Cyanopica;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Why helping others? The role of direct fitness benefits within the social-networks in cooperatively breeding azure-winged magpies;1/05/2015;30/04/2017;;"'Current literature on the evolution of cooperation agrees that kin selection cannot explain the benefits accrued by cooperators in many systems. One main gap is the type of direct benefits that helpers obtain in cooperative breeding systems and how they are ESS provided that natural selection favours defectors over cooperators in unstructured populations. Recent advances show that 'social viscosity' can maintain benefits for cooperators. Thus, the study of social-network structure can potentially explain why cooperation persists. This type of approach can only be tackled after a long-term study at individual level. I have monitored a population of cooperative breeding Azure-winged magpie (Cyanopica cooki) for more than 20 years. I have pedigree data, their reproductive behaviour in helper and breeder roles, and lifetime reproductive success for many birds. Yet, the reason why helpers contribute to rearing other birds' offspring has remained elusive. Here I will use network approach to previous data plus new monitoring of breeding groups to study: the role of kinship, by using pedigree and genetic analyses; the structure of social networks based on cooperative relationships, to see whether interactions can explain the maintenance of cooperative behaviour from the point of view of reciprocity and generalized reciprocity predictions; potential paternity sharing between breeders and helpers; and the relative roles of different benefits in lifetime inclusive fitness. I will implement the project within the team of Dr. Rita Covas, who has solid experience in the study of cooperative breeding. I present an innovative but realistic workplan to test original questions with new methodologies that are expected to lead to strong publications. The collaboration proposed means the reinforcement of the contribution of Mediterranean biology into ERA, the re-integration of a woman to scientific activity, and the collaboration between women heading research lines in Europe.'";160635,6;160635,6;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;ICETA INSTITUTO DE CIENCIAS, TECNOLOGIAS E AGROAMBIENTE DA UNIVERSIDADE DO PORTO;PT;;; 195432;657331;CaMILLET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Application of crop genetics to improve Calcium content in millets and other crops for promoting health benefits in the prevention and treatment of osteoporosis;1/09/2015;31/08/2017;;"With osteoporosis becoming an increasing threat to human health, this project is directed towards finding an inexpensive solution to this problem using crop genetics. Biofortification of human diet with food that are naturally rich in Calcium (Ca) is proposed. Among all cultivated cereals, finger millet (Eleusine coracana), an annual small millet of Africa and Asia, has been found to have the highest concentration of Ca (350mg/100g) in its grains. This proposal aims to investigate the genetic variations of Ca accumulation in finger millet germplasm using chemical phenotyping and genomics, and to use this knowledge in further improving the concentration of this micronutrient in finger millet and other staple crops. Specific objectives of the study are: (1) to explore the extent of genetic diversity for Ca content present in world collection of finger millet germplasms; (2) to identify genomic regions associated with Ca accumulation in finger millet grains using next generation sequencing, chemical phenotyping and GWAS analysis; (3) to identify and validate candidate genes underlying genomic regions found to be associated with Ca accumulation in finger millet; and (4) use comparative genomics to identify similar genes and processes in staple cereals like wheat, rice, barley or oats grown in Europe. The project will identify genes involved in Ca accumulation in crops and the prospects of their breeding into new varieties through plant breeding. Such crop varieties will benefit the smallholder farmers who will grow them (by adding value to their food products) and also provide valuable, superior raw material to industries for developing functional food rich in Calcium. Availabilities of such food and food products will increase Ca consumption and reduce the health and economic impacts of osteoporosis.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ABERYSTWYTH UNIVERSITY;UK;;; 195426;657286;ICSIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The interaction and clearance of senescent vascular cells by the innate immune system;1/06/2015;31/05/2017;;"Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease. Therefore, the aim of this research is to understand why senescent cells accumulate later in life for the purpose of identifying potential therapeutic strategies for eliminating senescent cells. This project, founded in an emerging field of ageing research, will determine the interaction and clearance of senescent cells by ageing innate immune cells.
Using in vitro, ex vivo and in vivo approaches the fellow will delineate the mechanisms of interaction between senescent vascular cells and the innate immune system and how they are impacted by age. This will significantly advance knowledge and lead to novel molecular targets to explore for eliminating age-associated vascular senescent cells. Since the field of cellular senescence is predominantly centred within molecular cell biology and cancer, this coordinated cross-disciplinary and cross-sectorial approach will provide novel insight into vascular senescence. Through an ambitious research training programme, the fellow will develop scientific, complementary and transferable skills in metabolism, innate immunity and vascular function in age-related disease from Aston, UK with intersectorial training to develop small molecule drugs from Redoxis SB, SWE; evaluate drug efficacy in models of ageing (Erasmus, NL); in the context of clinical cardiology (Aston/City Hospital, UK). It will deepen collaborations for partners, provide new techniques to the hosts and enhance the skills of exceptionally talented research fellow, with over ten years experience in the field of cellular senescence, forward as a research leader with experience of working effectively across sectors.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195442;657424;QuantumLaP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum Effects in Multicolor Ultrafast Laser Processing: Broadening Boundaries of Classical Descriptions;1/09/2015;31/08/2017;;"In this project the interaction of ultrashort laser pulses with semiconductor materials will be investigated on a principally new level by taking into account quantum effects that can emerge in highly-excited non-equilibrium matter. The central goal is to study bi-chromatic irradiation regimes which have been found to be extremely effective, compared to monochromatic laser beams, for various applications from micro-/nanostructuring of surfaces to nanoparticle generation and film deposition. This topic will be addressed through the development of a new powerful large-scale 3D model of laser-matter interaction. For the first time two modeling approaches will be combined, electronic structure theory and classical electrodynamics. Necessary steps to achieve these goals are:
Making an existing classical FDTD model to be self-consistent via introducing feedback to the laser field from the swiftly evolving free electron population;
Extending the model to the large scale 3D domain to account for realistic response of materials to polarized laser light;
Modelling of the action of bi-chromatic laser light on semiconductors at the quantum level based on the time-dependent density functional theory (TDDFT); developing a theory of photo-ionization of materials by mixed laser wavelengths;
Bridging classical large-scale simulations of ultrashort pulse excitation of semiconductors with quantum peculiarities of photo-ionization.
The key goal of the project is to demonstrate the power of the developed model in predicting the morphology of functionalized surfaces for materials of various properties under new irradiation conditions in collaboration with experimentalists at HiLASE. By providing in-depth understanding of underlying physics, this work will open the way to achieve the control over functionalization of semiconductor surfaces, thus, pushing this field away from empirical methods to a smart computer-predicted technique.";142720,8;142720,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FYZIKALNI USTAV AV CR V.V.I;CZ;;; 195464;657527;MelonMixVir;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mixed viral infections in melon: disease, vector transmission, RNA silencing suppression and plant defense;16/06/2015;15/06/2017;;"MelonMixVir deals with mixed viral infections in melon plants. Pathogenic viruses are collectively responsible of relevant economic losses worldwide, but most plant virology studies are done with a few individual viruses, while the frequent cases of mixed infections are clearly underrepresented. In contrast, severe synergistic effects can occur in mixed infections, even between viruses causing mild or no symptoms when alone. Consequently, the lack of knowledge about multiple infections difficult the risk evaluation in numerous crops. For instance, in cucurbits only a few studies are addressing this situation, despite that recent surveys are showing the frequent occurrence of mixed infections. The main purpose of MelonMixVir is to fill this gap, providing new knowledge and scientific advice to minimize the damage caused by viruses in melon, and thus improving production and quality, and raising the economic benefits to Europe.

To do so, we intend to explore the potential similitudes of melon plants co-infected by potyvirus (WMV) \ crinivirus (CYSDV) with the better-known similar pathosystem that results in sweet potato virus disease (SPVD). The comparative analysis will focus on several steps, including transmission by insect vectors (aphids and whiteflies), plant defense mechanisms (based on RNA silencing), and the pathogen responses (by action of RNA silencing suppressors). Virology, entomology and molecular biology approaches will be used to better understand the different processes.

This ambitious project is tailored to complement the expertise of the candidate, allowing her to progress in a career as plant pathologist. Outcomes include the design of new management strategies and recommendations for reducing damages caused by viruses. The work will be done in straight collaboration with a partner organization, the seed private company Semillas Fit, to fulfil the purpose of providing a clear practical application to the knowledge generated.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB;ES;;; 195446;657440;InSIght;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Information from Symbols and Illustrations: how to get it without vision;1/09/2015;31/08/2017;;"In everyday life individuals are bombarded with symbols and illustrations: poisonous, flammable, fire evacuation route etc.; however this life-saving information is not accessible to all of us.

One in 30 Europeans experiences sight loss, including one in three individuals over 65 years of age. These individuals cannot recognise a face, or read a symbol or an illustration: they rely on their sense of touch.

Those who use touch mix up angles and curves over 50% of the time which makes interpreting tactile symbols and illustrations problematic: the Euro symbol () may be mistaken for the capital E; the Pythagorean triangle may have no right angle. This mix-up has serious consequences:
Lack of awareness of important, sometimes life-saving information. This is a particular problem for individuals with low tactile sensibility (often caused by age, diabetes or stroke). Marie Sklodowska-Curie herself experienced this double disability (blindness and low tactile sensibility);
Shortcomings in school, e.g. in science, where teaching relies on symbols and illustrations

The objective of the InSIght project is to investigate in what configuration(s) of shape features angles are perceived as angles, curves as curves and straight lines as straight lines and if misperceived, why. These results will be the basis for a visionary project to develop a checklist and teaching guide on tactile symbols and illustrations. Through this strategy InSIght will improve awareness of important, potentially life-saving, information and reduce shortcomings in school, e.g., in science; thus the environments costs for special needs education. Finally, InSIght will reduce the environments costs by leading to development of universal design standards for tactile symbols and illustrations.

InSIght will produce four academic and non-academic articles, and develop a non-academic booklet with the checklist and teaching guide. It will set up a European conference and an interactive webpage.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195394;657123;PHYSIO-POP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Physiological and environmental controls of water and ozone fluxes in a short rotation poplar plantation: from leaf to tree to ecosystem scale.;1/09/2015;31/08/2017;;"One of the consequences of global climate changes is the altered global water availability. Among the greenhouse gases (GHGs) causing global climate changes, carbon dioxide (CO2) has received most attention. Over the last decennia the impact of rising CO2 concentrations on crops has been widely studied. The study of tropospheric ozone (O3) and its consequences on crops has not been as extensive, although O3 is a widespread and damaging air pollutant in industrialized countries. The PHYSIO-POP project fits within the search for renewable (bio-)energies, in particular the production of woody biomass energy. The project will examine the water consumption and the sensitivity to O3 pollution of a short rotation poplar plantation with fast-growing poplars (Populus spp.) for biomass production.
The multidisciplinary and interdisciplinary approach followed by this PHYSIO-POP proposal aims to improve our knowledge of the impact of global climate change by studying the physiological and environmental controls of water and O3 fluxes in different short rotation poplar genotypes at all relevant biological (leaf, tree, ecosystem) and time (daily, seasonal) scales. To achieve this objective the project makes the unusual combination of plant (eco-)physiological studies at the leaf and the tree levels with model simulations at tree and ecosystem levels to improve our understanding of what happens at the whole plantation, from the leaf to the ecosystem scale over the individual tree level.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT ANTWERPEN;BE;;; 195355;656900;DualNRSQNM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fundamentals of Holographic Dualities via Non-relativistic Systems and Quasinormal Modes;1/09/2015;31/08/2017;;"'Since their advent, holographic dualities have been a major focus of theoretical physics research. These dualities are maps between field theories in d dimensions, and gravities in d\1 dimensions. In these maps, any physical quantity in the field theory has a dual in the gravitational theory, and vice versa. 'Dual' means that a calculation in the field theory will always give the same answer as a calculation in the gravitational theory (and vice versa). These dualities thus provide powerful access to new physical descriptions. They have been applied far beyond their original high-energy theoretical physics regimes, to subjects ranging from superconductors to heavy-ion collisions.
This project will study the underpinnings of holographic dualities for applications to non-relativistic systems like superconductors. In order to put these conjectured applications on stronger footing, this project will also examine the role played by 'quasinormal modes' in dualities.
During her graduate work at UC Berkeley, and her postdoctoral positions at Harvard and University of Michigan, the proposed fellow has acquired ample research experience in the areas covered in this proposal, and will be able to expand on collaborations with some of the world experts in the field.
The proposed host institution, the Niels Bohr Institute (NBI), provides an ideal fertile environment for developing research at the forefront of physical understanding, and particularly so for this project due to local expertise among its faculty, postdocs, students, and thriving international visitor program.
During this project, the fellow will acquire further skill in the cross-disciplinary areas of the proposal, including condensed matter physics as well as mathematics. The host, fellow, and the EU as a whole will benefit from the international exchange of ideas results from the mixing of the fellow's US backbackground with the strong EU-wide connections of the host institution.'";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195411;657227;DoRoThy;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Donating Robots a Theory of Mind;7/09/2015;6/09/2017;;"'This project aims to advance the science and technology of meta-cognition in social robotics. During social interactions, humans use powerful cognitive mechanisms to represent and interpret what others know or intend. Doing so helps us respond appropriately in social interactions: we use a combination of sensory perception together with internal models of what others are (and will be) doing and thinking. We believe these capabilities to be equally important for social robots, a type of robot which is intended to interact with people. Endowing robot with skills to read the minds of others is not only key to build next-generation assistive and industrial robots, but also presents a considerable research challenge. A challenge with tremendous benefits but few successes to date.

Relying both on a novel formal approach based on modal logics, and on a strong experimental component in real-world conditions, this proposal suggests an ambitious interdisciplinary approach to better comprehend and formalize higher-order artificial cognition. The aim of which is to advance the design and practical implementation of socially interactive robots, in line with the Horizon 2020 Future and Emerging Technologies priority of moving 'cognition beyond problem solving'.'";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF PLYMOUTH;UK;;; 195504;657749;NeuroUTR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Systematic investigation of the functional coupling between transcriptional and post-transcriptional regulatory interactions underlying tissue-specific 3'UTRs variability.;1/06/2015;31/05/2017;;3' untranslated regions (3' UTRs) serve as a key platform in the RNA regulatory network that controls mRNA translational efficiency, localisation and stability. Of all human cell-types, brain-specific isoforms have the longest 3' UTRs and therefore their regulation is likely to be most complex. Moreover, mutations perturbing the mRNA secondary structure and sites of mRNA-miRNA interactions can lead to diseases such as neurodegeneration. Isoforms of variable 3' UTRs are engendered by alternative cleavage and polyadenylation (polyA) site selection. Of the many factors contributing to this process, both transcriptional and RNA regulatory interactions have been extensively studied. Yet the regulatory mechanisms responsible for the systematic tissue-specific polyA site selection remain largely unknown. Here I hypothesise that changes in transcription factors, RNA binding proteins, and polyA factors activities together regulate the condition-specificity of this process. Furthermore I hypothesise that the resulting 3' UTR sequence variation contributes to increased protein aggregation in neurodegenerative disorders such as motor neurone disease (MND), a common but incurable disorder in which mRNA metabolism and protein homeostasis are disrupted. Here using bioinformatic approaches I will integrate a variety of genomic measurements, and systematically identify tissue-specific transcriptional and post-transcriptional regulatory interactions underlying polyA site selection. I will develop linear models to characterise the genome-wide functional coupling between these regulatory interactions and study how these associate with MND in regulating alternative 3' UTRs. In doing this project I will not only advance our current knowledge about RNA regulation but I will enable a better understanding of the regulatory mechanisms underlying MND, and in the long term, the future development of new therapies that ameliorate the regulation of 3' UTRs in neurodegenerative diseases.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE FRANCIS CRICK INSTITUTE LIMITED;UK;CANCER RESEARCH UK;UK; 195410;657223;EWTEK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Empowering Women with Traditional Ecological Knowledge;1/07/2015;31/05/2018;;"In rural Morocco, women are the gatekeepers of Traditional Ecological Knowledge (TEK) linked to natural resource management.Women have been underestimated for their important contribution to producing and securing food, managing natural resources, and their ability to earn an income through these activities. Even though massive aid budgets from the major donors, including the European Union, are allocated to expand Moroccos programmes to combat poverty, social exclusion and gender inequality, rural women are still poorly integrated in Moroccan society. Using an original interdisciplinary approach of ethnobiology, development studies and geography, this study will explore whether women are able to gain social status and economic development through applying their traditional ecological knowledge in the context of the Green Morocco Plan in two rural communes of Rhamna Province. The study will cover the two main issues: 1) an analysis of the socio-historical, political context of the country, to assess the interests and motives of the Moroccan government to address gender issues; 2), an ethnographic investigation into womens traditional knowledge activities looking in particular at the transfer of womens traditional knowledge and environmental practices to new income generating activities. The policy relevance of the study lies in its aim to ensure that a gender aware rural traditional dimension is included in programme policies with concrete proposals on how to overcome rural womens socio-economic stagnation, and improve the working conditions of rural women in Morocco. It will contribute to the current debate of gender analysis, environmental practices and womens integration in development programmes. The Fellowship is expected to deliver a curriculum to expand this new field of enquiry to resolve issues of social exclusion. It will open up perspectives of employment for the researcher in a European academic institution or a policy research institute.";236257,7;236257,7;H2020-MSCA-IF-2014;MSCA-IF-GF;ERASMUS UNIVERSITEIT ROTTERDAM;NL;;; 195557;658145;3D-ADAPT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Analysis of tridimensional changes caused by type 2 Diabetes-Associated varianTs;1/06/2015;31/05/2017;;Despite the worldwide growing incidence of type-two diabetes (T2D), the molecular mechanisms are largely unknown. Genome Wide Association Studies (GWAS) have identified dozens of loci harbouring common SNPs that affect T2D susceptibility. The host lab recently showed that many associated SNPs lie in clusters of islet-specific regulatory elements that form tridimensional chromatin structures in the nucleus. This project aims to evaluate how common genetic variation could impact the tridimensional chromatin structure and transcriptional activity at the level of broad regulatory domains, and ultimately assess its influence on T2D risk. To this end, allele-specific chromosome conformation capture maps will be developed and analysed together with existing reference regulatory datasets of expression profiles, histone modification marks and transcription factor occupancy in human islets. To further define the function of allele-specific interactions, genetic modification experiments will be carried out on selected disease-relevant regulatory elements. These studies can shed novel insights on how common sequence variation contributes to T2D susceptibility and can lead to the identification of novel non-coding functional variants.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER;ES;;; 195678;658876;Forests and CO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Co-Benefits and Conflicts between CO2 sequestration and biodiversity conservation in European Forests;1/10/2015;30/09/2017;;Intact forests harbor large amounts of carbon and unique biodiversity, suggesting that protecting forests may benefit climate change mitigation and biodiversity conservation alike. Yet, forests also provide other essential services, from timber to energy to recreation. Balancing these multiple, sometimes conflicting objectives requires understanding trade-offs and synergies among them. A key question in this context is whether schemes to maintain or increase carbon stocks through forest management actually co-benefit biodiversity. Although frequently promoted, assumptions about such co-benefits have not been rigorously assessed. Forest and CO will test whether policies designed to protect either biodiversity or carbon in Europes temperate forests are synergistic or conflicting. Three work packages (WP) will focus on both unmanaged, old-growth forests, representing a baseline for key ecosystem functions, and managed forest, constituting the majority of Europes forests. WP1 will build a network of forest researchers to gather existing data on old-growth forests in Europe, and create the first map of their distribution. WP2 will use plot-level data to model the relationship between forest biodiversity and carbon storage, and assess whether this relationship differs between old-growth and managed forests. WP3 will test whether carbon/biodiversity co-benefits vary, when scaled up to broader extents, using satellite products and vegetation-plot databases. This action will provide new insight into the synergies and trade-offs between carbon and biodiversity in temperate forests and develop methods to map these trade-offs. Scientifically, this will contribute substantially to the fields of forest ecology, conservation science, and sustainability science. From a policy perspective, Forest and CO will help to tailor forest management options to jointly foster carbon and biodiversity, thereby contributing to key policy goals on curbing climate change and biodiversity loss.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HUMBOLDT-UNIVERSITAT ZU BERLIN;DE;;; 195451;657473;BioFrost;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Life at its Extremes: Biodiversity and Activity of Microorganisms in deep Permafrost;1/04/2015;31/03/2017;;"BioFrost will offer the unique opportunity to descend to the frozen depths of Earth, into permafrost, and study the microbial life as it carries on in an unhospitable, (almost-)inhabitable, environment where temperatures are far below zero and no oxygen is available. Supported by a highly sensitive experimental approach based on the use of stable isotope probing combined with Next Generation Sequencing, Fourier transform ion cyclotron resonance mass spectrometry and nanoSIMS, this research will trace active microorganisms in deep permafrost and will reveal their abundances and taxonomic identities together with the biologically-induced chemical processes that modify the surrounding environment and make it more habitable. This study will also address one of the most significant new concepts of modern microbiology, the heterogeneity of single microbial cells, and will assess the role of it in the context of the ecosystems overall functioning.
This project is for microbiologists and environmental scientists, who want to expand their knowledge on microbial biodiversity and activity in the coldest regions of Earth. It is also for space and planetary scientists, who are preparing for upcoming missions to Mars permafrost in search of signatures of life. It is for environmental policy makers to promote consciousness of a hidden subsurface ecosystem that can impact critically on us at the surface. Most of all, I hope this Marie Sk?odowska-Curie (MSC) project will meet anyone curious about life at its extremes.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELMHOLTZ ZENTRUM POTSDAM DEUTSCHESGEOFORSCHUNGSZENTRUM GFZ;DE;;; 195465;657533;EMoGrIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ecological Modelling of the Greenland Ice Sheet Surface Ecosystem;1/01/2016;31/12/2017;;Glaciers and ice sheets contain distinct ecosystems and are very vulnerable to the ongoing climate change, with potentially significant impacts. However, predictions of future glacier ecosystem change are virtually impossible due to the lack of a theoretical framework of glacier and ice sheet ecosystems that would enable their mathematical modelling. The principal aims of the proposed fellowship are to provide a theoretical framework of the microbe-dominated supraglacial (glacier surface) ecosystem of the Greenland Ice Sheet and to develop a tool for prediction of the future change of the ecosystem, and to establish the Greenland Ice Sheet as a model ecosystem for studying microbial biogeography and diversity patterns. This will be achieved through developing a conceptual model of the system, its mathematical formulation, verification and validation, and subsequent simulations of future climatic scenarios. Furthermore, a sampling strategy will be developed allowing direct testing of relevant ecological hypotheses such as the diversity-productivity relationship. A two-way knowledge transfer is a key feature of this project: The Fellow will take advantage of the expertise of the Supervisor and the Department in ecological theory and modelling, while transferring his knowledge of glaciers as microbe-dominated ecosystems to the Department.;142720,8;142720,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERZITA KARLOVA;CZ;;; 195623;658560;DYS_FUNCTION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Novel use of exon skipping technology to study structure-function relationship of dystrophin;1/01/2016;31/12/2017;;"Duchenne muscular dystrophy (DMD) stems from loss of dystrophin in skeletal and cardiac muscles, which leads to loss of ambulation and cardio-respiratory failure. The most promising treatment that could be applicable to 83% of DMD patients is exon skipping, a technology where the EU is a world leader. Antisense oligonucleotide mediated exon skipping targets DMD pre-mRNA to induce skipping of specific exons and restore the open reading frame. This allows expression of shorter dystrophin proteins that lack domains encoded by the skipped exon(s). A crucial question is how to predict which short dystrophins will be stable and functional. This knowledge is fundamental to select DMD patients that would most benefit from this treatment and identify exons worth targeting via exon skipping.
The goal of this proposal is to develop a new use of exon skipping technology to rapidly generate mouse models to screen short dystrophins for in vivo stability and functionality in both skeletal and cardiac muscles. This is made possible by a new exon skipping chemistry developed in the UK with unparalleled skipping efficiency in vivo and capable of targeting the heart. I will use this technology to create mouse models for two short dystrophins generated in DMD patients undergoing exon 51 skipping in the current UK clinical trial. I will then biochemically assess their stability and functionality in limb, cardiac and respiratory muscles. Parallel histological studies will assess the presence of muscle pathology with a focus on heart and diaphragm that cannot be sampled in DMD patients. This project will serve as a trampoline for future studies to identify dystrophin exons that when skipped will produce functional proteins with clinical benefits. In addition, this research will generate new fundamental knowledge on dystrophin domains critical for muscle function and may help in the prognosis of DMD patients currently undergoing exon 51 skipping.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITY COLLEGE LONDON;UK;;; 195427;657292;RAPID-KDM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Application of peptide screening technology for identification of substrates of the Jumonji-C histone demethylases;1/10/2015;30/09/2018;;In recent years it has become evident that the functional human proteome is vastly expanded by post-translational modifications (PTMs) that modify protein function and gene expression in a time- and context-dependent manner. Misregulation of these modifications leads to developmental disorders and often contributes to disease biogenesis. However, with the possible exception of protein phosphorylation, the full roles and regulation of these modifications remain poorly understood. Currently, in particular, arginine methylation is proposed to be largely stable and irreversible. Building on my exciting preliminary data that demonstrate that Jumonji C histone demethylases (JmjC KDMs) can catalyse removal of arginine methylation, this proposal aims to identify biologically relevant methylarginine substrates of the JmjC KDM. Cutting-edge mRNA display-based peptide screening technology will be adapted for use as a substrate identification assay in collaboration with Prof Hiroaki Suga at the University of Tokyo. Consensus sequences identified using this novel methodology will be used to identify biologically relevant peptide sequences by bioinformatic searches. On the return to the UK, results with isolated proteins will be correlated with in-cell studies and the functional consequences of these reactions assessed. Given the high level of interest in the post-translational modification field, the results of this study will be of interest to a very wide-range of scientists including other academic researchers in the field of epigenetics and beyond, and major biotechnology and pharmaceutical companies studying JmjC KDMs as drug targets. The fellowship will provide training in state-of-the-art techniques. The collaboration between the University of Oxford and the University of Tokyo will enhance the research capabilities of the European Union, promote cross-fertilisation of knowledge and strengthen research ties with Japan.;270271,8;270271,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195449;657465;AuNP-PhotoBioDrug;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Functionalized AuNPs and their use for biological applications;13/05/2015;12/05/2017;;"The development of gold nanostructures is a topic of high interest due to their extensive use in biomedical applications, biosensing and bioimaging because of their specific properties: high stability, ease of detection, facile synthesis and functionalization, etc. It would be of potential interest to predict the photobehaviour of AuNPs before introducing them in a biological environment. In this respect, when NPs interact in a living milieu, proteins will adsorb onto its surface generating a protein corona; this may provoke changes in the biological function of the protein and in the photophysical properties of the AuNP; thus, the photophysical behaviour of AuNPs in solution cannot be directly extrapolated to the biological media. These effects have been barely investigated up to now. The design of new gold nanoparticles whose photophysical behaviour can be extrapolated in a greater degree to a biological environment is of potential interest for in vivo applications due to the fact that their photobehaviour would be predictable within cells. Functionalization of AuNPs with nonsteroidal anti-inflammatory 2-arylpropionic drugs is proposed. These drugs are widely prescribed and are able to generate cytotoxic singlet oxygen, which induces cell tumour death. Their photophysical properties have been well characterised in solution. However, to the best of our knowledge, functionalization of AuNPs with drugs of this family has never been performed. The photophysical properties of the new nanomaterials will be studied in different microenvironments that tend to mimic cellular milieus, such as micellar or microemulsion media. Investigation of their photobehaviour in the presence of proteins is also planned. Finally, studies in an intracellular environment and in vivo will also be performed in order to check the potential application of the new conjugates as biosensors or photodynamic therapy agents.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF EAST ANGLIA;UK;;; 195417;657247;MOLCLICK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Molecular 'Click-tronics': Surface-based synthesis of single-molecule electronic components;1/10/2015;30/09/2018;;"How can single-molecules be best utilized in electronics? Feature sizes of integrated circuits will reach this scale in 10-20 years (Moores Law). Typical molecular studies involve surface self-assembled components first synthesised elsewhere (ex situ). Yet surface-based (in situ) preparations offer several distinct synthetic advantages also simplifying the construction of otherwise difficult to prepare asymmetrical surface-bound motifs.

In this project I will (i) explore unconventional in situ syntheses of single-molecule electronic components, and (ii) develop scanning tunnelling microscopy (STM) techniques to assess the success of chemical reactions at the single-molecule scale. High yielding and versatile (e.g. Click ) reactions will prove invaluable in this context. My largely unexplored approach will be used to rapidly screen novel single-molecule diodes and wires, improving rectification ratios and conductance. It will also be applied to produce complex molecular test-beds, allowing electron transport to be probed through single-molecules orientated parallel to the surface (enabling studies of mechanically weak analytes). This research has broad application and far-reaching impact in data storage and computation (wiring-up molecules in circuits), and will open up exciting possibilities in sensing and catalysis.

Project results, and nano-science in general, will be actively promoted through a series of Outreach workshops, lectures (implemented in Europe) and a new internet blog, Nanotechnology, Translated (contributing to the growing international science blogosphere). A planned secondment to the microelectronics industry will provide commercial and technical insights useful for securing funding and developing future technologies over the next two decades. The new collaborations and enhanced international profile, networks and training provided by this Fellowship will ultimately prove pivotal in helping me establish my independent academic career.";246668,4;246668,4;H2020-MSCA-IF-2014;MSCA-IF-GF;Universit de Rennes 1;FR;;; 195343;656853;Symbiosis;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bacterial leaf symbiosis: what environmental factors influence it and does it drive host plant speciation;1/01/2016;31/12/2017;;Virtually all plants interact with endosymbiotic microorganisms that inhabit various plant organs. The biotechnological applications of endosymbiotic bacteria can be numerous (e.g. sustainable agriculture through biocontrol and biofertilization). Accordingly, current research efforts have focused on the molecular mechanisms involved in microbial endosymbiosis. Although these interactions can be beneficial, neutral or detrimental to the host and may play a larger role on host fitness and survival, the long-term effects of endosymbiosis on diversification patterns are still unknown. In this project, the ecological conditions for the establishment of leaf endosymbiosis and the long-term effect on the host plant speciation will be studied for the first time through a unique combination of plant diversity, endophytes, ecology and time. The key scientific objectives are (1) to identify the significant environmental factors influencing the presence of bacterial leaf symbionts and (2) to test if bacterial leaf symbiosis acts as a driver for speciation. This will enable us to answer under which circumstances endosymbiotic plant-bacteria interactions are established in nature, what is the stimulus of these interactions, and what are the consequences for the evolutionary history of both endosymbiont and host. This knowledge will provide a better understanding of the impact of long-term endosymbiosis on plant diversification processes. A central aspect of this proposal is the synergy between the applicant and the beneficiary. The pioneering PhD work of the applicant in the field of bacterial leaf symbiosis will now be taken to a new and predictive level by adding an evolutionary perspective with the help of the expertise of leading scientists studying the impact of biological interactions on biodiversity, state-of-the-art facilities including next generation sequencing and a vibrant and internationally renowned research community at the Natural History Museum of Denmark.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195431;657314;MBLIs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New Approaches to Metallo-?-Lactamase Inhibitors;1/07/2015;30/06/2017;;The increasing problem of antibiotic resistance is a major global public health concern. In the EU 25,000 patients die each year due to infections caused by multi-resistant bacterial pathogens, and the EU spends at least 1.5 billion euro per year on healthcare costs. The ?-lactam antibiotics are the most important antibiotics representing >60% of small molecules in clinical use. BLAs contain a ?-lactam ring which is critical for penicillin-binding protein inhibition. However, BLA efficacy is declining due to resistance mechanisms including the widespread occurrence of ?-lactamases, which catalyse ?-lactam hydrolysis. Metallo-?-lactamases, long-considered as of little clinical relevance, now present a serious global threat to almost all BLAs, rendering the development of approaches to MBL inhibitors important. Unlike the serine ?-lactamases, the MBLs are structurally and mechanistically unrelated to PBPs, and are not inhibited by current mechanism-based SBL inhibitors. Due to variations in MBL structures, a major challenge in MBL inhibition is the development of compounds with the breadth of selectivity necessary for clinical utility. Society is now in an alarming situation and there is a clear need for the development of an MBLI:?-lactam-based combination therapies. The aim of my proposed work is to pioneer, enable and inspire the generation of broad-spectrum MBLIs active against a panel of clinically representative MBLs, but inactive against human enzymes with related active sites. To obtain the desired objective, novel approaches are proposed and include the use of phosphonates and phosphinic acids for: (a) MBL-directed DCC coupled to analysis by non-denaturing ESI-MS and 31P-NMR, (b) 31P-NMR reporter screening method, (c) pre-equilibrated DCLs for MBL-directed DCC, and (d) the synthesis of modified inhibitors. The study will be interdisciplinary and encompass organic synthesis, biological MS/NMR, structural biology, and medicinal chemistry.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195340;656843;EDPAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Regulation of early embryo development and pluripotency through alternative splicing;1/07/2015;30/06/2017;;Understanding how the differentiation potential of the mammalian embryo gets restricted during development is a key question in the embryology and stem cell fields. Alternative splicing (AS) is the process by which different exons are selected in precursor mRNAs to generate multiple protein products. Recent studies have shown that 95% of human multiexonic genes undergo AS, however little is known regarding its role in modulating pluripotency and differentiation. The aim of this project is to study the role that AS plays in these processes. For this we will first use ultra-deep coverage RNA-sequencing data from three mammalian species to identify alternative exons that show conserved dynamic usage during early developmental stages. Second, we will functionally test in ESCs the role of a number of these isoforms in pluripotency maintenance. Finally, we will take advantage of the CRISPR-Cas9 technology to generate exon specific knockouts in mouse embryos in order to assess their role during early embryo development. The results obtained from the proposed research will add to our knowledge of the regulatory networks that control early embryo development and will improve our understanding of the biology of stem cells, which is essential for their effective use for therapeutic applications. In addition, the use of state-of-the-art technology and a multi-disciplinary approach to analyze mammalian pluripotency regulation will improve my expertise in this field, helping me to gain independence in the near future.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO CENTRE DE REGULACIO GENOMICA;ES;;; 195379;657027;CoEvolFramework;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unified Framework for the Analysis of Co-evolutionary Systems;1/02/2016;31/01/2018;;Today's challenges are marked by more frequent and wide-spread episodes of social, economic, political and environmental crisis. Co-evolutionary systems offer a natural perspective and powerful tools to help us understand conditions that affect populations of agents whose behavior changes in response to their interaction outcomes in situations of strategic decision-making. Studying these complex co-evolutionary systems remains an open challenge as rich structures in the models are not taken into account. The overarching aim of this project is to fill this major research gap with a unified, principled framework to analyze complex co-evolutionary systems. At the core of our approach is the graph representation of interacting agent behaviors where problem structures are fully captured by complete orientations in the graph and associated co-evolutionary dynamics by sampling processes on the graph. This project combines complementary expertise of the Experienced Researcher (Dr. Chong) in large co-evolutionary systems and the Supervisor (Professor Tino, University of Birmingham) in complex, adaptive and dynamical systems. Its vision is that the framework provides foundation for new modelling tools benefiting policy-makers, regulators, and academics through better understanding and predictive quality of real-world strategic decision-making systems.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195396;657128;LEXICON POETICUM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Lexicon Poeticum: A lexical resource for Old-Norse Icelandic skaldic poetry and its relevant social fields;1/08/2016;31/07/2018;;The proposed project will establish me as the leader of the next generation of researchers in key fields of Old Norse studies. I will gain a major new disciplinary base in my broader field and experience in leading a major project which will help to train and engage a new generation of scholars. The project analyses the language of Old Norse skaldic poetry, one of the main sources for the history, culture and religion of early Scandinavia. It is a highly valuable corpus for many fields: much of it dates from the Viking Age and was the principle source for medieval historians for that period. Its language and form is extremely complex, which has made it inaccessible to non-specialist scholars and the general public. Since the poetry was first rediscovered it has been recognised that it contains a large vocabulary distinct from that of prose: some 10,000 different Old Norse words occur only in poetry. The project Skaldic Poetry of the Scandinavian Middle Ages has made this difficult material accessible to a broad audience. The present project builds on that work, documenting and mapping the words of this poetry. The main output will be an electronic dictionary linked to the text corpus and translation. I will address a long-standing and well-recognised gap in the lexicography of Old Norse, superseding the problematic Lexicon Poeticum of 1931. My approach is built on the state-of-the art textual philology and digitisation methodologies of the Skaldic Project. At the Department of Nordic Research I will develop lexicographic methodologies to produce the new dictionary, which will for the first time link the words of the corpus to their material evidence, realised in digital technologies. The resulting resource will provide the foundation for further linguistic and literary analysis of skaldic poetry. It will thus help to answer questions about the religion, culture, society and history of Scandinavia and its deep and long-standing connections with the rest of Europe.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195489;657621;EI-USAXS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Imaging ultra-small angle x-ray scattering with edge-illumination: exploiting sub-pixel information in medical diagnostics, materials science and security screening;1/06/2015;31/05/2017;;"The capability to image the microscopic features of a sample with an imaging system with much coarser resolution opens tantalizing opportunities to all applications of x-ray imaging. First and foremost, it can reveal features that are currently inaccessible: coupled with e.g. a widely available x-ray microscope with a resolution of a few microns, it can reveal information on nanoscale details. However, one can also envisage a use of the same capability to maintain a given, required level of resolution while using much larger pixels, which could allow lower dose in medical imaging, faster scans in industrial or security inspections, cheaper imaging system or any combination of the above.
The method to image the Ultra-Small Angle X-ray Scattering (USAXS) distribution developed by the Experienced Researcher (ER) of this application enables exactly this tantalizing feature. It was developed as an additional, advanced feature of phase-based dark field imaging methods enabled by e.g. grating interferometry (GI), and was the subject of two recent Phys. Rev. Letters.
GI is a phenomenal new phase imaging approach but has limitations in terms of transferability to systems that could be used clinically or by industry. Since real-world implementations of his method are the ERs key objective, he has identified in edge illumination (EI) phase contrast imaging, developed by the supervisor of this project, the tool that would enable the development of a prototype making the ERs USAXS imaging method widely available.
This project will develop this prototype and test it on significant samples in medicine, material science and industrial and security scanning in direct collaboration with the end users. It will complement the ERs skills on the development of benchtop imaging systems and significantly enlarge the range of his interdisciplinary skills and collaborations. At the same time, it will enrich the host group by providing access to a new imaging method with huge potential.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195436;657357;WINTERC-3D;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Thermochemical imaging of the Earths mantle: Global inversion of seismic waveforms, satellite gravity data and surface elevation;1/03/2015;28/02/2017;;The thermochemical structure of the Earths lithosphere and underlying mantle controls fundamental dynamic processes including volcanism, seismic activity and surface topography variations. The growth of very large terrestrial and satellite geophysical data sets over the last few years, together with the advancement of petrological and geophysical modelling techniques, now present an opportunity for global, thermochemical 3D imaging of the lithosphere and upper mantle with unprecedented resolution. Established methods of seismic tomography and gravity data analysis constrain distributions of seismic velocity and density at depth, both depending on temperature and composition of the rocks within the Earth. However, independent modelling and inversion or a simple combination of models based on gravity and seismic data alone suffer from the intrinsic non-uniqueness of each type of models. Thermodynamic links between seismic velocities, density, temperature, pressure and composition within the Earth can now be modelled accurately using new methods of computational petrology. This project combines state-of-the-art seismic waveform tomography (using both surface and body waves), newly available global gravity satellite data (geoid and gravity anomalies and new gradiometric measurements from GOCE mission) and surface elevation within a self-consistent thermodynamic framework. A new method for global thermodynamic tomography will be developed and applied to obtain a robust and, at the same time, detailed thermochemical model of the Earths lithosphere and upper mantle.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DUBLIN INSTITUTE FOR ADVANCED STUDIES;IE;;; 195395;657125;TARGEPILIVER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of Key Epigenetic Targets in Hepatic Fibrosis and Hepatocellular Carcinoma Development. Generation of New Antifibrotic and Antitumoral Drugs.;1/12/2015;30/11/2017;;"Liver fibrosis represents a common pathogenic pathway in most chronic liver diseases (CLDs) and cirrhosis, its end stage, is a huge healthcare burden. The main causes of CLD are chronic viral hepatitis B or C infection, alcohol abuse and obesity-linked steatohepatitis, conditions with increasing global incidence. Hepatocellular carcinoma (HCC) develops on this background of CLD as a multistep process in the context of chronic inflammation and cirrhosis. Among all non-hematological malignancies, HCC has the fastest rising incidence of any neoplasm in USA and Europe. Despite all the progress in understanding the cellular and molecular mechanisms of liver fibrosis and hepatocarcinogenesis, there are no effective therapies to halt fibrosis or quell liver cancer. Exposure to environmental factors triggers adaptative epigenetic mechanisms, including alterations in DNA methylation or post-translational modification of histones, which control gene expression and ultimately cellular behaviour in ways critical for the development of CLD and HCC. From the literature and our preliminary observations it is known that many of the enzymes carrying out these epigenetic events, such as DNA and histone methyltransferases, present altered expression and activity in CLD and HCC. The deposition of methyl marks in histones and DNA are very dynamic enzymatic processes, amenable to pharmacological intervention and therefore constitute attractive therapeutic targets. Our proposal has two main objectives: first the analysis of the expression, activity and pathological significance of DNA and histone-methyltransferases in models of CLD and hepatocarcinogenesis; and second the development of new efficacious DNA and histone-methyltransferase specific inhibitors with a good safety profile, which is critical when treating patients with compromised liver function. These new epigenetic therapies could be used to prevent CLD progression, and to treat HCC alone or in combination with existing drugs.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA;ES;;; 195608;658464;DEGASS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An experimental approach to understand inDuced sEismicity in GAS Shales;1/01/2016;31/12/2017;;Natural gas recovered from shales is becoming an increasingly important energy source worldwide. The hydrofracturing technique used to obtain shale gas can cause unstable fault slip, giving rise to induced seismicity, but has recently been shown to also lead to stable, slow-slip fault behaviour. Successful, safe and publically accepted global implementation of shale gas recovery critically depends on understanding the conditions leading to the different types of fault slip. The principal objective of the proposed research is to determine the conditions and the microscale deformation mechanisms that lead to stable versus unstable fault slip of reactivated faults in clay- and quartz-rich gas shales. This objective will be achieved by a combination of experiments, microstructural analyses and microphysical modelling work, to be conducted primarily at the University of Liverpool (ULIV), UK, complemented by a secondment in the non-academic sector. This work builds upon my PhD and postdoctoral work that focussed on the slip-stability of similar clay-quartz materials, but from subduction zone megathrust settings. New techniques available at ULIV, together with the novel links with industry to be established in the research, will bring about a major advancement of my academic career. This fellowship will thus contribute to the achievement of the goals of the Horizon 2020 Work Programme. The main end-products of this study the physical properties of gas shale, either measured or predicted with a microphysical model for gas shale deformation, can be implemented by shale gas companies to plan and monitor their hydrofracturing activities better. These results will also serve as a sound basis for public education. The outcomes of the study, i.e. a more fundamental understanding of, and microphysical basis for, phyllosilicate-quartz friction, will also be of importance for the broader community concerned with fault friction notably subduction megathrust friction.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF LIVERPOOL;UK;;; 195542;658056;OSCAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Operando study of the catalytic activity of gold nanoparticles by Surface Differential Reflectivity Spectroscopy (SDRS): from plasmonic response to morphology;31/03/2016;30/03/2018;;The outstanding catalytic activity of gold nanoparticles (NPs) on metal-oxide supports has attracted enormous interest not only for fundamental understanding but also for the design and synthesis of a new generation of efficient catalysts. At the current time, one of the main technical challenges for gold catalyst applications is the stability in terms of sintering during use. As for many heterogeneous catalysts, the characterization of the gold NPs morphology in operating conditions is essential for progress towards practical use. The issue is currently treated by X-ray diffraction at synchrotron radiation facilities. The present project (OSCAR) foresees a breakthrough. It aims to develop an optical method, namely Surface Differential Reflectivity Spectroscopy (SDRS), to determine operando at the laboratory the shape and size of NPs on the basis of their plasmonic response. The challenge is to combine non-invasive SDRS measurements for determining NP morphology to reactivity measurements in realistic conditions. The case study is the archetypal case of CO oxidation on supported gold NPs, for which the relationship between NPs size/shape and reactivity is vividly debated. The catalytic activity of gold NPs will be examined both on a reducible substrate, rutile TiO2(110), and on an irreducible substrate, MgO(100) films on Ag(100), to determine the crucial role played by the supporting metal-oxide substrate.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;FR;;; 195412;657233;Safe and Sound Drive;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Design of a serious game for cars to help increase driver skills and lower fuel consumption;1/09/2015;31/08/2016;;New in-vehicle information systems and advanced driver assistance systems are currently being introduced in cars in order to help driving safely and energy efficiently. These systems help the driver to pay attention to critical events (e.g. collision warnings and blind spot information systems) or deliver important information (e.g. speed limits and navigation instructions). However, safety and environmental impact are most of all dependent on the behaviour and attitude of the driver. This proposal concerns the design of a serious game for cars that will help drivers to increase eco-driving skills, lower fuel consumption and encourage safe and environmentally friendly approaches to driving. Through his research, Dr Arne Nyknen has developed successful methods and procedures for efficient product sound design, already implemented at Volvo Cars and Scania. Anglia Ruskin University has leading expertise on creative and user-centred design, serious gaming, mobile applications and sound design for theatre and film. Combining this expertise enables the introduction of sound based serious gaming in cars. This provides a successful way to increase driving safety and decrease environmental impact of cars, by not only informing and warning the driver, but also changing attitudes and behaviour. The major outcomes of the project will be a demonstrator of a serious game implemented in a car, a mobile app publicly available for download, demonstrations at science centres in the UK and Sweden, 3 journal papers, participation in 4 conferences, and a new European expert network with partners from academia as well as car, game and audio engineering industry.;97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ANGLIA RUSKIN UNIVERSITY HIGHER EDUCATION CORPORATION;UK;;; 195434;657347;LBSKQ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Location Based Suggestion of Keyword Queries;1/04/2015;31/03/2017;;"Query suggestion is a recent and important add-on feature of Web search engines (e.g., Google), which helps users to express their information needs precisely. Specifically, given the fact that the user may not be able to find appropriate keywords for her search, the system recommends to her a small set of keyword queries that are likely to match her original intention. As an example, when a user searches for convertible car, she may miss all the documents indexed under cabriolet. Therefore, the engine suggests cabriolet as a follow-up query to the user. There has been extensive research in the past decade on effective query suggestion. However, none of the existing keyword query suggestion methods consider the users location. We argue that the queries suggested to a user not only should be semantically relevant to her original query, but also should give results near the users location, especially when these queries are expressed by a mobile user; otherwise, the suggested queries might not be of interest to the user. Therefore, there is a need for effective location-based keyword query suggestion (LBKQS) models. The objectives of this project are (1) the development of LBKQS models, (2) the evaluation of the proposed models, (3) the development of efficient and scalable LBKQS techniques based on the most effective models. In the end, we expect our system to provide appropriate query suggestions to mobile users in real-time.

The subject of this project is timely and of great interest to the research community and IT industries, therefore the research publications that will arise from it will improve the visibility of European research internationally. The Experienced Researcher (ER) has a notable publications record and extensive experience in subjects related to the proposal (spatial, textual, spatio-textual data management and mining). The project will help him to (i) enhance his skills in the areas of recommender systems, distributed/mobile data managem";164653,2;164653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;PANEPISTIMIO IOANNINON;EL;;; 195402;657187;REVEAL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Peering through the East Antarctic Ice Sheet to reveal geology, crustal architecture and tectonic influences on ice sheet dynamics;18/05/2015;17/05/2017;;Although East Antarctica is regarded as a keystone in the Rodinia and Gondwana supercontinents and is a pivotal component of the global climatic system it remains the least known continent on Earth. With REVEAL we aim to unveil the crustal structure, tectonic architecture and evolution of several major frontier regions in East Antarctica. The project will also address large-scale geological controls on bedrock topography, subglacial hydrology and ice sheet dynamics. Our models and interpretations of potential field data will enable us test several hypotheses regarding the effects of collision, accretion and rifting on East Antarctica. This has significant implications for comprehending the impact of supercontinental assembly and break up on the structure and evolution of East Antarctica. Using state of the art three dimensional modelling, we will obtain an enhanced understanding of intraplate mountain building in the enigmatic Gamburtsev Subglacial Mountains region. This is highly significant, as these mountains were critical for East Antarctic Ice Sheet development. The enhanced knowledge of subglacial geology that will derive from our analyses of the Recovery Frontier and Wilkes Land will facilitate new assessments of the influence of geological boundary conditions on the dynamics and the stability of these potentially more vulnerable marine-based parts of the East Antarctic Ice Sheet. The REVEAL project has a strong international dimension and will deliver several high-profile publications and dissemination activities. It will provide unique and timely training and career development opportunities for the experienced researcher.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATURAL ENVIRONMENT RESEARCH COUNCIL;UK;;; 195328;656810;DENDRONUTRIENT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Disentangling the effects of CO2 fertilization, nutrient limitation and water availability on forest ecosystem processes: Estimating their long-term consequences on SW European forests;1/03/2016;28/02/2018;;"European forestry is fast evolving as forests could experience in the near future important changes in climate and also in management, which is moving from timber production to values such as bioenergy, carbon sequestration, biodiversity and others. These factors could change the idoneity of traditional forestry in Scots pine forests (which cover important areas in Europe). The projects objectives are: 1) To characterize past and estimate future effects of forest management and climate change on carbon and nutrient budgets in Pinus sylvestris stands in SW Europe, to support sustainable forestry that maximizes nutrient and carbon use efficiency and therefore tree growth; 2) To develop, evaluate and apply reliable ecologically-based mathematical models that can be applied in forest management, to study interactions among elevated atmospheric CO2, tree growth and limiting nutrients and moisture. To achieve these objectives the project will be implemented in three stages: 1) Field and archival samples form experimental plots in Scot pine stands in the Pyrenees will be used to analyze connections between soil, leaf and stem nutrient status in the last 16 years. The magnitude of ecosystem biomass and nutrient pools will be estimated to calculate the historical change of nutrient use efficiency by the pines. Historical leaf NUE will be estimated through leaf area scanning combined with chemical analysis. Stem water and nutrient status will be estimated by wood scanning combined with techniques discriminating isotopes of carbon and nitrogen. 2) The ecosystem model FORECAST-Climate will be calibrated, validated, and used as a virtual lab to test the relative importance of nutrient, water, and CO2 availability on tree growth. 3) A battery of climate change (temperature, precipitation and CO2 concentration) and forest management scenarios will be simulated to assess their long-term consequences and provide guidelines on the potential consequences of each management option.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD PUBLICA DE NAVARRA;ES;;; 195663;658742;CONTESTED URBANISM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Contested Cities Revisited: a multidisciplinary, multi-scale analysis of urban space;1/04/2015;31/03/2017;;"'The proposed projects meta-objectives are twofold, first; from a theoretical perspective the starting point of the project is the suggestion that rather than limiting the 'extreme divided city label to a selected number of contested places, there is an increasing need to broaden the category itself in order to deepen the understanding of contested urbanism across the spectrum. Secondly, to construct an innovative interdisciplinary research method connecting the long overdue qualitative and quantitative divide within urban segregation research (Vertovec 2006). Within this discussion, there is a still significant lacuna as to how researchers and policymakers themselves conceptualize and prioritize the socially and politically contentious issues of urban segregation in different cities and the impact of urban space on social outcomes (Vaughan 2007). This research project suggests there is a need to re-think labels and concepts attributed to cities and neighborhoods, to better adapt planning policy and practice to ethnic minorities and migrants in an ever more fractured urban reality.

Following a broad assessment of 'urban segregation' the research will focus on two nations with diverse forms of contested urbanism with the aim of 'learning through differences, rather than seeking out similarities' (Robinson 2011); namely Sweden (known for its comprehensive welfare system) and Israel (known for its ethnically based policies); selecting four case study cities (two from each country) with high levels of ethnic minorities for further in-depth analysis. With the aim of establishing a multi-level multidisciplinary comparative framework (engaging spatial and qualitative analysis); the project will integrate three main scales of investigation: (1) the nation state role in planning for urban segregation, (2) urban segregation at the city scale, and (3) the role of local community and civil society in, and their perception of, these urban processes.'";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195325;656782;PETITE GUERRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Experiences and Memories of French and Algerian Veterans. Remembering the 'petite guerre' in the Aurs-Nememcha;1/09/2015;31/08/2017;;The present study aims to investigate the Algerian War of Independence (195462) from a new perspective. It proposes to frame a transnational history of the war, going beyond both the (opposing) French and Algerian (national) narratives, to resituate the war in its Mediterranean, European, and eventually its global contexts. This general research objective, however, will be achieved by using a microhistorical approach: instead of looking at the conflict as a generic whole and examining its reverberations in an elusive collective memory, the project focuses on a specific region, the Aurs-Nememcha in the Algerian south-east. At the core of this project are the specific experiences and memories of French and Algerian veterans who fought each other for eight years, in this mountainous, Berberophone area. Who were they? What kind of war were they fighting, and why? And fifty years after the ceasefire, how do the citizens of each country cope with their combat memories? The project will mobilise a wide range of sources, mostly but not exclusively French and Algerian. Aiming to analyse both past events and their present memories, this study will rely on both qualitative and quantitative analytical methods, in a truly interdisciplinary framework. Indeed, this global microhistory approachbeyond being an original contribution to historical researchaims to offer new knowledge of and insights into the Franco-Algerian War, in order to help the two countries to go beyond the narrow national narratives that continue to fuel an unexhausted memory war that is ongoing both between and within Algeria and France. If the efforts of the EU and the Union for the Mediterranean (2008) may help to set a new tone in the near future, today it is less at the state level that it is possible to act than at the level of the people, by focusing on their particular and familial stories.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195364;656954;KimberliteNewApproach;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A new approach to revealing the composition of kimberlite melts and their deep mantle source;1/04/2016;31/03/2018;;"The overarching aim of this project is to provide novel constraints on the composition of the Earths deep mantle, particularly its volatile content, by undertaking an innovative geochemical and isotopic study of the deepest formed melts on Earth: kimberlites. Kimberlite melts are derived from depths in excess of 150-200 km. They are important as the major host of diamonds and because entrain xenoliths (i.e. fragments) of upper mantle and deep crustal rocks during ascent to the surface, providing a major source of information about the geochemistry of the deep Earth. Despite their importance, the composition of primary kimberlite melts and their exact mantle source are hotly debated issues. This is due to contamination of kimberlite melts by mantle and crustal rocks during magma emplacement and near surface alteration of primary kimberlite mineralogy.
To determine the composition of primary kimberlite melts, I will employ a novel approach that combines radiogenic (Sr-Nd-Pb) and stable (C-O) isotope fingerprinting of melt inclusions in kimberlitic magmatic minerals (i.e. olivine and spinel), using innovative ultra-sensitive techniques. This approach will constrain if the carbonate-dominated melt inclusions truly represent examples of pristine kimberlite magma by quantifying processes like crustal contamination and degassing that may have altered the melt composition. I will investigate kimberlites from targeted localities from different parts of the world (South Africa, Canada, Greenland, Russia) and of variable age (Proterozoic to Cretaceous) to assess if there are spatial and/or temporal controls to kimberlite composition. The melt inclusions C-O isotope data, coupled with O isotope analyses of kimberlitic olivine, spinel and perovskite, are designed to test if recycled crustal material occurs in the deep mantle source of kimberlites, which would provide important new constraints on the global cycle of volatiles through geological time.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VU;NL;;; 195474;657596;NICOS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nonlinear optical coatings at high intensities;1/10/2015;30/09/2017;;"Optical interference coatings have become a key enabling technology for many laser systems. Modern oscillators and amplifiers are capable of generating ultrashort pulses with energies of several tens of J at repetition rates of more than 10 MHz, resulting in several hundreds of watts of average output power. Under the illumination of optical coatings by such intense optical fields, the nonlinear effects manifest themselves. These effects can be exploited for development of novel types of nonlinear optical (NLO) laser components: dielectric multilayer coatings with specified nonlinear properties. In order to use the potential of dielectric coatings as NLO devices, the nonlinear behaviour of dielectric multilayers at intensities which are, from one side, high enough to activate nonlinearities and lower, from other side, than laser damage threshold, has to be carefully explored. As structures of films differ from the ones of bulk materials, then characterization of nonlinear effects in dielectric coatings is to be carried out and numerical values of coatings nonlinear parameters are be estimated.

NICOS project is aimed at accurate and reliable characterization of nonlinear effects in dielectric coatings and development of new types of NLO dielectric multilayers for laser applications. In order to resolve project tasks, a combination of four main elements is required: (1) laser systems to generate high intensity pulses inducing nonlinear effects in multilayers, (2) deposition plants to produce the coatings, (3) measurement tools to characterize the effects and (4) background in modelling and optical technology. Unique research facilities of the Host Institution together with Applicants expertise in optical coatings provide a basis for successful implementation of the project. The results of NICOS will be a valuable contribution to nonlinear optics, laser physics and thin film technology. NICOS will assist in pushing frontiers in promising laser components.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195381;657039;Repower Democracy;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Repower Democracy: How grassroots energy initiatives are changing the face of democracy in Europe;4/05/2015;3/05/2017;;When in 2013, a multinational energy corporation started to set up a drilling site in ?urawlw a village in eastern Poland residents sprang into action to protest the plans to use fracking (an unconventional method of shale gas extraction). Like social movements in the recent global wave of protest (such as Occupy, Indignados), they engaged in egalitarian organising. Finally, the corporation abandoned the village but the residents' activism did not end. Like the citizens in ?urawlw, similar anti-fracking groups in Europe are working on initiatives to build democratically-run renewable energy solutions. This project investigates the potential of such groups for a repowering of democracy, i.e. a reformulation of democratic models and a reorganisation of energy production along more egalitarian lines. The main objectives of the research are: (1) to investigate the forms of politicisation and imaginaries of egalitarianism in Polish and British communities and (2) to build interdisciplinary, inter-sectoral collaborations and draw up research-led strategies for local and systemic social innovation in the field of democratic self-organisation of energy initiatives. I will employ ethnographic research, local historical and rural sociological investigation to identify best democratic practice models of the communities. Through participatory action research and together with research participants we will develop and implement a framework for the assessment of community's energy potential. The projects' interdisciplinary nature contributes to critical enquiry into the possibilities of more democratic futures and their interrelationship with transitions of energy systems. The core focus is on the local dynamics of grassroots organising and its intersections with (inter)national structures. The overarching aim is to repower democracy in Europe to help its citizens to be actively engaged in democratic processes by taking responsibility for tackling major societal challenges.;196400,4;196400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITETET I BERGEN;NO;;; 195416;657244;SilentFACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Functional networks and cancer roles of the essential histone chaperone FACT;1/06/2015;31/05/2017;;"Our knowledge of the mechanisms underlying cancer rapidly evolves. Diagnosis and treatment are improving, but cancer remains an urgent health burden. Whole-genome sequencing of cancers by the International Cancer Genome Consortium reveals that a key driving force in the etiology of cancer is the abnormal expression of chromatin regulators. The SilentFACT project focuses on an essential regulator of chromatin structure, the histone chaperone FACT. Recently identified small molecules disrupt normal FACT functions, and cancer cells stop growing when FACT levels are reduced. This reveals FACT as an anti-cancer target. We will apply potent cutting-edge genomics, quantitative proteomics and biochemical approaches to systematically dissect and validate the functional networks, novel interactors and chromatin targeting mechanisms of FACT. We will then subject the identified major interactors to a small molecule screen targeting FACT in human cancer cells. This will occur during secondments to the chemical biology platform of the Curie Institute in Paris and at an industrial partner.

The SilentFACT project supports a Polish chromatin researcher for two years research and training at Munich University. Our timely research, training and communication aims, as well as exchanges with the international research community, will markedly advance the chromatin field, determine how this essential protein complex is involved in cancer and advance the therapeutic potential of FACT- targeted small molecules. SilentFACT will establish a solid basis for drug development, and advance the researchers leadership, networking and employability, helping to establish an independent research program at this exciting interface between basic chromatin science and translational medicine.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195450;657466;INPATH-TES;SIGNED;H2020-EU.3.3.6.;LCE-20-2014;H2020;PhD on Innovation Pathways for TES;1/05/2015;30/04/2018;;"Following the EC SET-Plan Education and Training Roadmap, the concept of this proposal is to develop a joint PhD programme between universities and research centres, on the topic of Thermal Energy Storage (TES). The goal of INPATH-TES is to create a network of universities and research institutes to implement a joint PhD programme on TES technologies. The final result of such a network is to educate professionals on these technologies for the European research and industry institutions. The consortium includes 14 universities that will implement the joint PhD programme, two research institutions (AIT and PROMES-CNRS), three companies and two SME (Arcelik, Abengoa Solar NT, KIC InnoEnergy, UFP and LAIF), that will cooperate in defining the programme and in its implementation and deployment. The specific objectives of the project will lead to the qualification of professionals for the European research and industry institutions, bringing Europe to continue being leaders in these technologies. The partners in the proposal will be the core of a future larger network of excellent R&D institutions, and industries for co-funding and industrial placement, sharing infrastructure capacities, and enhancing mobility of students. The overall approach of the project involves a work plan divided in six work packages, being either coordination or support activities. Coordination activities: WP1 Management and coordination; WP3 Developing, maintaining and updating a PhD programme in TES; and WP4 Implementation of the PhD programme in TES. Support activities: WP2 External communication and dissemination; WP5 Stakeholder involvement and extension of partnerships; and WP6 Framework for monitoring and evaluation of INPATH-TES as well as IPR and regulatory issues.";4301072,66;4301072,66;H2020-LCE-2014-2;CSA;UNIVERSIDAD DE LLEIDA;ES;"UNIVERSITY OF CUKUROVA;DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;UNIVERSIDADE DO MINHO;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;UNIVERSITEIT GENT;POLITECHNIKA WARSZAWSKA;USER FEEDBACK PROGRAM SL;CONSORZIO PER IL LAVORO E LE ATTIVITA' INNOVATIVE E FORMATIVE;BEN-GURION UNIVERSITY OF THE NEGEV;INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;RIGAS TEHNISKA UNIVERSITATE;UNIVERSITAT DE BARCELONA;KIC INNOENERGY SE;UNIVERSITA DELLA CALABRIA;ABENGOA SOLAR NEW TECHNOLOGIES SA;TECHNISCHE UNIVERSITEIT EINDHOVEN;UNIVERSITA DEGLI STUDI DI PERUGIA;ARCELIK A.S.;UNIVERSITY OF ULSTER";"TR;DE;PT;AT;IE;BE;PL;ES;IT;IL;FR;LV;NL;UK"; 195421;657263;GATEWAY;SIGNED;H2020-EU.3.3.2.;LCE-19-2014;H2020;Developing a Pilot Case aimed at establishing a European infrastructure project for CO2 transport;1/05/2015;30/04/2017;;"The OBJECTIVES of this proposal are as follows
a) to define a subsequent initiative, referred to as the Pilot Case, providing a model for establishing a European CO2 infrastructure project, targeting a gateway transferring CO2 from source to sink. The gateway will form the first leg of a cross-border network, allowing multiple sources and multiple sinks.
b) to make profound assessments of the substantial funding needs and available resources.
c) to solicit strong actions by the partners involved (member states of the EU and other countries) with a three-step approach (Berlin model).

The objectives will be ACHIEVED by acquiring commercial and legal input from various sources, such as industries, research alliances and institutes, investors and funding agencies, and engage industries capable of providing the knowledge of how to initiate the first gateway(s) of a future European CO2 transport system. This will include
- knowledge gathering, involving structured intelligence processes,
- outline strategies,
- assessment of lead times,
- scenario building,
- consideration of funding synchronization issues.
- assessing the economic potential(s), timing, and organisation towards the deployment of CCS within Europe, and gradually increase the deployment so that it applies to Europe as a whole, thus providing a Pan-European infrastructure for CO2 transport,
- the initiation of a strict planning of the infrastructure, including the handling of specific policy issues and regulatory requirements.

These objectives demonstrate a clear RELEVANCE to the H2020 Work Programme, calling for proposals for a pilot case addressing areas and challenges targeted in the competitive low-carbon energy call. This proposal pursues activities that support 'the use of research outcomes by industry of a project resulting from synchronised funding processes by at least three Member States', as addressed in the LCE-19 call.";787700;787700;H2020-LCE-2014-2;CSA;SINTEF ENERGI AS;NO;"FORSCHUNGSZENTRUM JULICH GMBH;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;PROGRESSIVE ENERGY LIMITED;UNIVERSITY OF LEEDS;ECOFYS NETHERLANDS BV;QUEEN MARY UNIVERSITY OF LONDON";"DE;NL;UK"; 195527;657949;LOBFRAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Lobbying and framing in foreign policy. EU and member states foreign policies towards Israel and Palestine;1/09/2015;31/08/2017;;"LOBFRAM aims to advance our understanding of lobbying and framing in foreign policy in the European Unions (EU) system of multi-level governance. While lobbying in the EU has received a lot of attention in recent years, lobbying in foreign policy remains a largely under-researched topic. Therefore, this project will explore the activities of non-state actors (NSAs), such as business groups, NGOs and solidarity movements, in EU foreign policy, investigating the networks that are established at different levels (EU and member states) and framing processes. The main contribution of LOBFRAM will be to investigate networks as transmitters of ideas. In turn, this will help us to analyse how frames are created, get codified and become collective frames influencing foreign policy at both the EU and member state levels, as well as what mechanisms of mutual interaction exist between EU and national foreign policy positions.

LOBFRAM will be based on an interdisciplinary approach building on international relations, EU studies, sociology and organizational studies and will rely on a mixed-methods approach. It will focus on the case study of the Israeli-Palestinian conflict, which is one of the most important policy issues on the EU and member states agenda, also in light of the strong commercial links with Israel, the crucial role as donors for the Palestinians and historical legacies. The project will zoom-in on three big member states, namely the United Kingdom, Germany and France, and identify similarities and differences among these member states as well as between them and the EU level when it comes to lobbying and framing activities.

The findings of this project will be published in a monograph and two journal articles and widely publicized to a non-specialised audience via outreach activities (e.g. a dedicated website, one policy brief and activities for students).";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FONDATION NATIONALE DES SCIENCES POLITIQUES;FR;;; 195380;657033;TEACHPOL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Freedom of Teaching and Political Control:The Case of Thomas Aquinas Assimilation in William of Peter Godins Lectura Thomasina (14th C.);15/05/2015;14/05/2017;;"The project intends to explore the speculative, historical, and political functions assumed by William of Peter Godins Lectura thomasina in the assimilation and teaching of Thomas Aquinas doctrines after the series of condemnations, censures, and corrections promulgated by some political authorities between the end of the 13th and the beginning of the 14th century. The text, still unpublished and preserved in fifteen manuscripts, does not represent a mere collection of Thomas dicta, but rather a sort of authorized handbook for students, which frequently replaced the direct lecture of Aquinas texts. In line with the educational policies, but true to Thomas intentions, the Lectura thomasina is an outstanding multidisciplinary document: it harmonizes speculative contents from Thomas Aquinas texts with political pressures and religious convinctions.
Through a comprehensive analysis of the work, a transcription of some selected passages, in which Williams reworking of censured Thomistic doctrines emerges, and, for the first time, the critical edition of a significant section of the text (Book II distinctions I-XXII), the research will focus on the Lectura thomasina as a case study that typifies the process of assimilation and transmission of groundbreaking ideas in a specific intellectual context, when it is subjected to political or religious restrictions. Then, the text will be a gateway to access a wider investigation on the contrasts between freedom of teaching and educational policy, recurring in many other cases in European intellectual history, and it will convert a specialists discussion on a medieval problem into a far-reaching intellectual challenge.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET ZU KOELN;DE;;; 195593;658351;MHAtriCell;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hyaluronan-rich matrices crosslinked with collagen-like peptides for 3D culture of ovarian cancer cells;15/06/2015;14/06/2017;;In recent years creation of artificial matrices from relatively simple biomaterials that can support tumour growth in 3D is becoming an increasingly popular platform for recreating the tumour microenvironment (TME) in vitro since 3D cell culture models can more realistically reflect the in vivo TME compared with 2D monolayer cultures. In this project, we will design and fabricate novel hydrogel matrices comprising of hyaluronan crosslinked with collagen-like triple helical peptide amphiphiles (PAs). The novel HA-PA matrix will contain built-in cell adhesion sequence, HA-binding motif and matrix metalloproteinase (MMP) cleavable sequences. We will characterise these 3D hydrogel matrices to support the encapsulation and culture of ovarian cancer cells. The MMP-assisted hydrogel degradation, migration and invasion of ovarian cancer will be studied on these models using advanced electron microscopic techniques and enzyme assays. In the final phase of our study we will characterise the inhibitory potency of a highly potent and selector inhibitor of MMP-2 and MMP-9 on this system. The findings from this study will have direct implications in understanding the mechanisms associated with ovarian cancer dissemination and the newly developed hydrogel matrix can find further use as a novel biomaterial in tissue engineering and as a 3D cell culture model in cancer drug discovery and delivery.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195419;657255;NeWMaBIL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neural correlates of working memory control in aged bilinguals;1/01/2016;31/12/2017;;Identification of factors that slow down cognitive depletion in ageing is today one of the main objectives of the aged society. Within the concept of cognitive reserve (CR), bilingualism has evidenced to shape cognition by enhancing the capacity of cognitive control (CgCnt). CgCnt and working memory (WM) capacities are strongly interrelated systems which are depleted by ageing. However, the exploration of how bilingualism shapes cognition in old populations is scarce and recently subjected to debate. Under this framework, sensitive approaches (such as the exploration of the neural oscillatory activity) that enable objective investigation of the effects of bilingualism on cognitive ageing are necessary. Neural oscillations represent the mechanisms responsible for cognition. Furthermore, they offer a direct measure of the cognitive architecture and of any reorganizational process accounting in the brain by factors as bilingualism. Nevertheless, the neural code of WM control in old bilinguals has not been explored yet. The current project aims to investigate, with magnetoencephalography (MEG), the neural correlates of WM control in young and old adult bilingual individuals. Resulting data will open a window into the role of bilingualism on the neural architecture of the working brain.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 195387;657076;HJMIGRA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Single-molecule analysis of Holliday-junction (HJ) migration by the human double-HJ dissolvasome;1/05/2015;30/04/2017;;The project outlined here investigates the molecular mechanisms of the critical final steps of homologous recombination (HR) based DNA repair, a pathway that supports the error-free repair of double-stranded DNA breaks (DSBs). In HR, the broken DNA ends are processed and homologous DNA provides a template for repair. Engagement of both processed ends leads to the formation of a double Holliday-junction (DHJ) structure. DHJ can be resolved by enzymatic cleavage or dissolved by the concerted action of a specialized group of helicases (RecQ-family helicases including Blooms syndrome helicase (BLM)) and Type I topoisomerases (e.g. TOP3A). In humans the dissolvasome complex consists of BLM, TOP3A and regulatory proteins (RMI1, RMI2), called the BTR complex. The BTR complex dissolves DHJ by 1. convergent branch migration of the two independent HJs and 2. decatenation of the final hemicatenate structure. Thus, dissolution solely results non-crossover products, which is necessary to avoid chromosomal rearrangements. What is the mechanism of HJ migration? What are the exact roles of the subunits of the BTR complex? How long can a HJ migrate (i.e. how processive is the dissolvasome)? How specific is the DHJ migration to the BTR complex compared to other human RecQ helicases? Here we aim to address these questions by using state-of-the-art single-molecule and solution biophysical and biochemical techniques. We will generate a previously inaccessible mobile HJ substrate integrated into ?-bacteriophage DNA. We will follow the processes underlying HJ migration by fluorescently labeling the BTR complex, HJ position and DNA end in total internal reflection fluorescence (TIRF) microscopy combined with microfluidics. Elucidation of the detailed roles of the BTR components in HJ branch migration will help us to understand their roles in genome maintenance.;146239,2;146239,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;ETVS LORND TUDOMNYEGYETEM;HU;;; 195648;658726;TIGER;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transposable element Impacts on Gene Expression and Regulation;19/10/2015;18/10/2017;;Transposable elements (TEs) are DNA sequences that are able to spread within and between genomes. While transposition may lead to evident harmful effects, TEs can also positively impact the host genome by, for instance, donating intrinsic regulatory elements such as promoters. The main goal of this research project is to understand the regulatory changes that TEs engage within host genomes. While in mammals TE-derived promoters are often observed, only recently Drosophila TEs were described as potential platforms of gene regulatory networks, opening a new field for important discoveries. Since TEs are extremely active in fruit flies and Drosophila is found worldwide, TE copies that are population-specific are observed. Drosophila constitutes therefore a perfect model to study the impact of TEs in the host transcriptome. We hypothesize that Drosophila TEs are able to act as gene promoters and cause differential gene expression between wild-derived strains. Our first aim is to discover strain-specific TE-derived promoters involved in differential gene expression between Drosophila melanogaster populations by using a genome-wide high throughput sequencing method named RAMPAGE. In our second aim we will determine how histone modifications regulate TE-derived promoters by producing chromatin maps for each strain studied. The comparison of full sites (sites containing the insertion of a TE in one population) with empty sites (sites devoid of a TE insertion in another population) allow us to clearly demonstrate the impact and regulation of TE promoters.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CLAUDE BERNARD LYON 1;FR;;; 195312;656730;GLIODIABESITY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ROLE OF THE TANYCYTIC BARRIER AT THE BLOOD-HYPOTHALAMUS INTERFACE DURING METABOLIC DISORDER DEVELOPMENT;1/07/2015;30/06/2017;;Metabolic disorders such as obesity and diabetes are age-related diseases, and lead cause of death in Europe. Adiposity signals such as leptin and insulin, whose circulating levels are in proportion to body fat, convey metabolic information to neural networks that regulate energy homeostasis in the hypothalamus. In leptin-deficient humans and mice, leptin administration effectively reduces hyperphagia and obesity. Paradoxically, most cases of obesity display high circulating leptin levels that fail to reduce appetite or increase energy expenditure. This raises the possibility that leptin transport across the blood-brain barrier to the cerebrospinal fluid (CSF) or to its sites of action within the hypothalamus is a limiting step defective in obese patients. The host laboratory recently demonstrated that tanycytes, a hypothalamic glia lining the floor of the third ventricle, were responsible for shuttling leptin from the periphery to the CSF and that such conduit was blunted in mice with diet-induced obesity. Leptin transport by tanycytes could thus play a critical role in the pathophysiology of leptin resistance. The overall objective of this project is to further elucidate whether the alteration of the adiposity signals transport into the metabolic brain across hypothalamic barriers is the main cause of the onset of obesity. To this end, a combination of in vitro and in vivo approaches, using genetically modified mice and pre-clinical models of obesity, will be implemented in order to elucidate the molecular mechanisms for the transport of blood-borne leptin into the CSF by tanycytes. It is anticipated that implementation of this project will expand our knowledge of the mechanism underlying human obesity and hold therapeutic potential for treating it. Besides, the proposed project is endowed of solid formative contents that will strengthen the experience of the applicant, boosting her future scientific career and paving the way for closer scientific collaborations.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE LILLE II - DROIT ET SANTE;FR;;; 195397;657135;MIDGESYM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Symbiotic bacteria in midges: understanding their role in determining vector competence and transmission of viruses;1/08/2015;31/07/2017;;The health of livestock is commonly impacted by viruses acquired from midge vectors. The viruses transferred following a midge bite cause considerable economic losses across the EU, making control of midges/midge vector competence a pressing concern. Recent research has indicated some inherited symbionts may alter the vector competence of their insect host, and thus represent viable means of interrupting pathogen transmission in natural populations. However, reduction of vector competence has only been considered for Wolbachia symbiont infections, and for viruses of importance to human health. Midges, in contrast, are commonly infected with a Cardinium heritable symbiont with unknown properties. This project seeks to establish tools for understanding this symbiont, and investigate whether it affects host immune system activity and vector competence following exposure to an infected blood meal. This proposal will thus provide both fundamental understanding of a poorly studied symbiont in an important host group, and, more practically, evaluate whether alteration of symbiont presence is a viable means of interrupting viral transmission.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF LIVERPOOL;UK;;; 195459;657510;BHLOC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Quantum Entropy of Extremal Black Holes;1/11/2015;31/10/2017;;The research proposed here is principally aimed at computing the full quantum entropy of black holes in string theory, especially in scenarios with reduced supersymmetry, by using localisation to evaluate supersymmetric path integrals. As an additional feature, we shall also explicate how more refined information about quantum black holes, rather than just the total number of microstates, may be extracted by these means. We shall further explicate the recently noticed appearance of mock modular forms in computations of black hole entropy in string theory.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195349;656882;REGMat;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rotational effects on strongly gravitating systems with matter;1/10/2015;30/09/2017;;"Black holes (BHs), where gravity is strongest in the universe, are the objects where we must confront the most extreme phenomena predicted by general relativity (GR) and extensions thereof. As for the majority of astrophysical bodies, BHs are typically spinning. However, addressing rotation in GR is notoriously difficult. Moreover, BHs are dirty: they are accompanied by clouds of gas or accretion disks, which introduce deviations from the known vacuum solutions. The complexity of the Einstein equations, taking into account the presence of matter and the rotation of spacetime, hampers attempts to model realistic BHs.

The prime goal of this research proposal is to deepen our understanding of BH dynamics in the presence of matter, and in particular the interplay between matter and the rotation of spacetime. This line of research will significantly advance our knowledge regarding the stability of more realistic (non-vacuum, non-spherically symmetric) BHs, as well as on outstanding issues, such as cosmic censorship.

Moreover, BHs nowadays are central to many areas of physics through the application of GR to fields other than the traditional ones of astrophysics and cosmology, namely to the more modern ones such as quantum gravity, high-energy physics (HEP) and strongly coupled quantum systems. Higher-dimensional gravity and the gauge/gravity duality provide a strong motivation to investigate BHs in contexts formerly regarded as removed from physical applications, in particular asymptotically anti-de Sitter (AdS) spacetimes of more than four dimensions. This proposal investigates, as a natural extension of the above-mentioned problems, the dynamics of rotating AdS BHs with implications for our understanding of thermalization in strongly coupled quantum theories.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE BARCELONA;ES;;; 195366;656971;EU and SSR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;LOCAL OWNERSHIP IN SECURITY SECTOR REFORM ACTIVITIES WITHIN CSDP OPERATIONS OF THE EU;7/10/2015;6/10/2017;;Between 2002 and 2014, the EU has deployed 30 civilian and military operations in Europe, Africa and Asia, under its Common Security and Defense Policy (CSDP). For most of these operations, the EU has a mandate to do activities related to the Security Sector Reform (SSR), aimed at the provision of national and human security within a framework of democratic governance. One of the core assumptions underpinning the EUs operations has been that SSR has to be locally owned in order to be successful, meaning that local agents should internalize principles and objectives of externally driven reforms. Local ownership, however, remains a neglected concept not only theoretically speaking, but it is also very difficult to be implemented in practice. The theoretical and policy gap informs three principal aims of this project. First, the project will adopt a fresh theoretical framework for the study of local ownership. Drawing on the work of Michel Foucault, the project will conceptualize local ownership as a technology of international security governmentality wherein external actors employ set of techniques with the aim of turning local agents into subjects responsible for externally-driven security sector reform agenda. Such an approach will situate local ownership of CSDP operations within a wider context of emerging liberal security governance and explain why it continuously face implementation difficulties in semi-liberal or illiberal settings. Second, the project will obtain new empirical insights into how local ownership is being practised on the ground within three ongoing CSDP operations (EULEX Kosovo, EUPOL COPPS and EUTM Mali) and into why these projects continue to face implementation problems. The third objective of the project is to develop a set of policy recommendations that will assist future policy planners in conceiving more reflexive, context-sensitive and cost-effective local ownership strategies to be applied in current or future CSDP operations.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195313;656725;StarlightWinds;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mass loss in the lives and deaths of massive stars;1/07/2015;30/06/2017;;"Across our Universe, the dynamics and chemical evolution of spiral galaxies like the Milky Way are primarily controlled by the lives and deaths of stars with masses many times that of the Sun. But the evolution of these massive stars is, in turn, highly regulated by the huge amounts of mass lost from their surfaces, by means of powerful starlight-driven winds. These stellar winds critically determine how such massive stars evolve through their lives, and how they finally die in giant supernova explosions. However, due to the very large quantitative uncertainties associated with this mass loss, present-day predictions for such massive-star evolution are seriously flawed.

The overarching goal of this ambitious project is to fundamentally improve this situation by using novel methods to develop new models of radiation-driven winds from hot, massive stars. Combining state-of-the art numerical NLTE radiative transfer and hydrodynamics with innovative analytic techniques and theory development, the applying researcher proposes to 1) develop new, drastically improved wind models from main-sequence massive stars, and 2) simulate the winds of the most massive stars known in the Universe as well as design the very first general predictive theoretical framework for the wind driving and mass loss from evolved Wolf-Rayet stars.

By furthermore examining the effects of the new mass-loss rates on models of stellar evolution, and carefully comparing the new simulation results with observations, this project will fundamentally improve our knowledge of the basic wind-physics of massive stars, as well as significantly contribute to our understanding of the evolution and ultimate fates of these stars. Indeed, the results expected during the fellowship will undoubtedly form the building blocks of many future scientific projects, allowing then for further progress also in the large number of research fields relying on a firm understanding of the lives and deaths of massive stars.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195401;657178;RESCBONE;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The influence of mechanical loading on the decline in bone mass with ageing;1/04/2015;31/03/2017;;"Osteoporosis is an age and gender-related condition characterised by reduced bone mass, impaired micro-architecture and increased risk of low-trauma fractures. Osteoporosis-related fractures are a major health concern and impose a huge economic burden on European health care systems. In the young, bone adapts its mass and architecture in response to strains engendered by mechanical loading. However, this response in blunted in the aged. We have shown that the anabolic response to load is similarly impaired in an age and gender-related manner in mice. Counter-intuitively, this response can be rescued in aged female mice if short periods of loading are imposed against a background of disuse rather than activity. We hypothesise that this rescue involves increased recruitment of bone forming osteoblasts.

The primary objective of this proposal is, to establish whether the age and gender-related decline in bones adaptive response to mechanical loading in mice can be attributed to insufficient recruitment of osteoblasts necessary to form new bone and, if so, whether this deficiency can be rescued by appropriate manipulation of bones loading environment.

To achieve the objectives in this proposal, we will investigate bones from aged male and female mice, which have been subjected to mechanical loading with or without prior disuse. These will be compared with similarly treated bones of young mice. Our studies should further elucidate the mechanisms underlying the age-related decline in bones adaptive response to mechanical loading. We hope that these studies could identify novel therapeutic targets to augment bones natural anabolic response to physical activity/loading. This could be of particular relevance in maintaining bone mass in situations of aging, paralysis or even space flight. The proposal will strengthen the CV of the applicant and further collaboration between European laboratories.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195435;657355;tRRACES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Resistance and Resilience of Ancient Agricultural Soils;17/08/2015;16/08/2017;;'The sustainability of an agricultural system relies largely on the resistance of soils -their capacity to perform its five environmental functions under disturbance- and in their resilience, meaning the capacity of the soils of restoring its functions after impact. The tRRACES project aims to get insights into how past or indigenous strategies for agricultural management drove pedogenetic pathways with a focus on the sustainability of the agroecosystem. New data on pedogenetic evolution of four ancient agricultural systems in Chile, Ethiopia Spain and Tanzania, spanning a wide range of environmental conditions, are to be put together with archaeological, ethnographical and paleoenvironmental knowledge, in order to show up the effects of ancient soil management strategies on the maintenance of soil environmental functions and therefore on soil resistance and resilience. The results will be used to predict the evolution of these systems when facing impending climatic and socioeconomic changes. tRRACES will provide a sound scientific basis for the so called 'indigenous knowledge' and will contribute highly valuable information for the studies on sustainable land-use, meaning that it is possible to state with confidence that the proposed project will undoubtedly produce useful data for modern developmental and conservationist narratives.';195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of York;UK;;; 195512;657788;MEHYB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Many-body effects in hybrid quantum systems;1/04/2015;31/03/2017;;"The interdisciplinary field of hybrid quantum systems pursues the integration of different quantum systems from AMO and solid-state physics to harness their combined functionalities in an optimal way. Prominent examples are long-lived spin ensemble quantum memories for superconducting qubits or (opto-)mechanical quantum transducers, which are currently experimentally implemented for future quantum information processing applications.

The general aim of this project is to identify and analyze a new and range of applications for hybrid quantum systems for the study of non-equilibrium quantum many-body effects and phase transitions in open quantum systems. For that purpose the hybrid system approach offers many, still unexplored advantages for combining dissipative and coherent elements in a controllable and scalable way. The focus of this project is two-fold: i) We will analyze the implementation of collective spin models in hybrid quantum system arrays consisting of spin ensembles coupled to microwave cavities and show that this system can serve as prototype model for identifying universal features of non-equilibrium phase transitions in open quantum systems. ii) We will study superconducting qubit arrays with integrated nanomechanical resonators for the implementation of spin models coupled to engineered local reservoirs. This will provide a first realistic approach for simulating open many-body quantum systems coupled to unconventional reservoirs, exhibiting, for example, strong site-dependent temperature variations, or mixed positive and negative temperatures. Analyzing these specific models will open a path for hybrid quantum system arrays as a new quantum simulation platform for non-equilibrium and open quantum many-body systems.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET WIEN;AT;;; 195365;656967;PYROCHEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biopolymers 13C tracking during fast pyrolysis of biomass-A 2-level mechanistic investigation;1/10/2015;30/09/2017;;The Marie Sk?odowska-Curie Actions (MCSA) proposal is the opportunity for Dr. Marion Carrier to reach a new level of understanding of fast pyrolysis mechanisms and improve the process and design of reactors by acquiring the necessary knowledge at a molecular-level and training using fractionation and isotopic characterization techniques, practical experience on micro-reactors and on larger scale laboratory reactors. It is proposed to use an integrated experimental and computational approach to provide molecular-level insights into pyrolysis chemistry by following the fate of 13C labelled lignocellulosic biopolymers, and subsequently to elucidate the main chemical events during the conversion of biomass. Empirical and mechanistic models will be combined to suggest a new kinetic model of fast pyrolysis. The thermal behaviour of individual unlabelled and labelled biopolymer carefully extracted will be investigated under controlled kinetic regime. The delineation and quantification of primary and secondary reactions will be achieved via the development of new devices for the collection of organic volatiles and via the implementation of spectrophotometric and spectrometric methods. For this, a combination of strong interdisciplinary expertise in several fields such as biopolymer chemistry, thermochemistry, aerosols trapping device fabrication, characterization of gas, liquid and solid products using spectrophotometric and spectrometry techniques is required. This multidisciplinary project will facilitate the commercialization of emergent renewable energy technologies such as fast pyrolysis via the optimization of bio-oil yields and quality, which is expected to offer alternative solutions in the co-production of fuels, high-value-added chemicals and energy, the main research activities of European countries members of the International Energy Agency.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195406;657194;Nu14Mig;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Generation and Application of Nucleophilic Allylmetal Species by Catalytic 1,4-Metal Migration;11/06/2015;10/06/2017;;"This proposed Fellowship brings together an Experienced Researcher from India with expertise in click chemistry, transition metal catalysis, and topochemical synthesis, with an internationally recognized Host Laboratory in the UK with expertise in the development of new catalytic reactions for organic synthesis. This project will:
Provide high-quality, tailored training for an outstanding scientist (possessing an excellent publication record) who is primed for an independent research career by complementing and enhancing his competencies.
Enhance European excellence in organic synthesis and catalysis, which are fundamentally important branches of chemistry that greatly impact upon many fields, such as the fine chemicals, pharmaceutical, agrochemical, materials, and biochemical industries.
The proposed research is based upon a completely new synthetic method recently discovered in the Host Laboratory that enables the generation of nucleophilic allylmetal species, which are widely employed in organic synthesis to prepare diverse compounds of interest. This method involves the catalytic carbometallation of the alkyne of a 1,3-enyne, followed by 1,4-migration of the resulting alkenylmetal species to the cis-allylic position of the enyne, which constitutes a special type of CH functionalization reaction. The resulting allylmetal species may then be trapped by an electrophile stereoselectively. It is our strong conviction that the possibilities of this chemistry are enormous, and the end result will be a generally useful synthetic method for the preparation of valuable building blocks as single enantiomers. This fellowship will therefore help Europe to remain globally competitive in the chemical sciences.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF NOTTINGHAM;UK;;; 195404;657189;DC cancer;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development and immunological control of dendritic cell cancer;1/05/2015;30/04/2017;;Dendritic cells (DC) are powerful antigen-presenting cells that can induce antigen-specific adaptive immunity to pathogens but also protective immunity against transformed self, i.e. cancer. This crucial role of DC makes them an attractive target in cancer vaccination. However, DC can also negatively regulate immunity by inducing antigen-specific tolerance and are a target in immunomodulatory approaches aimed at dampening autoimmunity or allergy. Given this dual role in immunity and tolerance it is hard to predict what would happen if DC were to become neoplastically transformed. Their immunogenic potential could make transformed DC highly susceptible to control by the immune system, which might explain why DC cancers are rarely observed in humans. In contrast, their tolerogenic potential could make transformed DC especially adept at escaping immunological control. So far, the aetiology of DC cancer and its immunological consequences remain elusive due to the lack of appropriate models to study the disease. In order to investigate the feasibility of DC tumour formation and the immune control of DC tumours, a novel genetically-engineered mouse model of DC cancer has been generated. We will use this model to characterise DC tumour development in vivo and establish which DC subsets contribute to DC cancer. Furthermore, we will adapt this model so that we can control the location and onset of neoplastic transformation of DC in vivo. Both models will then be employed to investigate to which extent DC cancer is recognised and modulated by cells of the immune system. Furthermore, we will assess whether transformed DC exploit tolerogenic mechanisms to progress into tumours. Our proposal will give novel insights into the biology of cancer development and its control by the immune system. We anticipate that understanding these processes will provide important insights into immune surveillance and the role of DC in anti-cancer immunity, helping to improve cancer immunotherapy.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE FRANCIS CRICK INSTITUTE LIMITED;UK;CANCER RESEARCH UK;UK; 195578;658261;RULE-THERM;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Real-time up-conversion luminescence thermometry based on lanthanide doped nanodiamonds in a living cell;1/01/2016;;;"This project will develop a novel thermometer based for intracellular temperature sensing application. Success will bring real-time high-resolution probing and imaging of temperature within living cells to the research community; this can promote novel insight about the pathology and, in turn, help establish a powerful tool in terms of its potential to support early diagnoses and therapies in a broad range of disease areas. In this respect the RULE-THERM project aims to contribute a foundational development of a technology with potentially wide applicability. The project brings together a talented young Fellow with a strong nano-science background and an internationally growing group of researchers at Aston University with expertise in diamond-based materials, which offer excellent biocompatibility and thus have a great potential for cellular interface.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195298;656697;ASF_SwineResistance;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;African Swine Fever, the Sus scrofa evolutionary genomic response;1/05/2015;30/04/2017;;African Swine Fever is a notifiable devastating hemorrhagic fever with high mortality rates in pigs. It affects all members of the Suidae family and is one of the most important pig diseases due to its severe socio-economic consequences for affected countries, the difficulty of preventing spread across country boundaries, and the lack of vaccine and therapeutic control measures. We will use genome-wide DNA technologies to understand the Sus scrofa genomic response to the infection. Specifically, we will compare data on both healthy and infected individuals to (1) identify the possible presence of regions under selection. We will also assess (2) the hybridization rate and (3) the interaction strategies between the domestic pig and the wild boar to (4) identify the possible transmission routes in pig diseases.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AALBORG UNIVERSITET;DK;;; 195633;658625;HAT-MOZ-sphere;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification of genes and pathways regulated by the HAT activity of MOZ;1/09/2015;31/08/2017;;The research programme will comprise the study of the Histone acetyl transferase (HAT) MOZ (Monocytic leukaemia Zinc finger) a critical player in the development and maintenance of the haematopoietic system. In addition, translocations of MOZ are associated with Acute Myeloblastic Leukaemia. Given the importance of this protein in haematopoiesis and leukaemogenesis, it would be essential to further understand the function of MOZ and in particular to identify the genes regulated by its HAT activity of MOZ. A mouse line specifically mutated to abrogate the HAT enzymatic activity of MOZ has been developed in the host laboratory, and represents a powerful and unique tool for the study of MOZ HAT activity. Using Chromatin ImmunoPrecipitation followed by sequencing (ChIP-seq), genome wide targets of MOZ will be determined and the consequences of the deletion of its HAT activity on the epigenetic landscape will be investigated through the survey of several histone modifications and RNA polymerase II recruitment. The non-histone targets of MOZ will be identified through the SILAC technique. Finally a MOZ murine leukaemic model has been developed, based on the transduction of bone marrow cells with a retrovirus encoding MOZ-TIF2, one of the fusion proteins involving MOZ. ChIP-seq will be performed in these leukaemic cells to identify genes targeted by MOZ-TIF2 and changes in epigenetic marks at these loci. Overall, this project will provide a better understanding of MOZ HAT activity in haematopoiesis and leukaemogenesis. Crucially, this project will enable Dr Anne Largeot to obtain and develop a wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195372;656997;Exo-C;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Insights into cloudy exoplanet atmospheres;1/01/2016;31/12/2017;;"Exoplanet science is a young and rapidly growing field of Astrophysics. One element crucial to advancing progress in the field is the analysis of exoplanet atmospheres, which carry unique information about the composition, birth and evolution of the planets. Exoplanets host clouds and haze that can mask the information imprinted in the planets atmospheres. Just as on Solar System planets, therefore, in order to successfully characterize exoplanets, understanding how clouds and haze form and their impact on atmospheric observables is essential. Motivated by these ideas, Exo-C will break new ground on three related aspects, namely: [1] the formation of upper-atmospheric haze through both neutral but also ion photochemistry; [2] the dispersion of haze through the atmosphere as transported by planet-wise winds; [3] the impact of cloud patterns on the net brightness of exoplanets. The Host Group is currently leading international efforts in exoplanet General Circulation Models (GCMs), as well as in atmospheric characterization; both aspects are key to the project and represent new expertise that will be gained by the Experienced Researcher (ER). The ER himself is well trained in the photochemical and radiative transport modelling of exo- and Solar System planet atmospheres, traits that complement those already existing in the Host Group. The multi-faceted expertise from the involved participants will provide the ideal framework to explore both the inter-disciplinary ideas set out above as well as new ones leading to long-lasting collaborations. The project is particularly timely because GCMs are becoming mature enough to enable comparison between model outputs and measurements in a way that will provide fundamental knowledge about exoplanet atmospheres and modelling capacities. Additionally, clouds and haze provide a critical yet currently missing link between GCMs and observations that the current project will help establish.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EXETER;UK;;; 195444;657434;PhoLED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Photonic nanostructures for Light-Emitting Devices.;1/09/2015;31/08/2017;;The PhoLED project seeks to largely surpass the optical performance of state-of-the-art light emitters devised for illumination applications and contribute to solve some of the main technical limitations that the current technology presents. This project aims at integrating novel optical nanostructures and emitters, such as colloidal quantum dots or nanophosphors, to yield the next generation of light-emitting devices in which full spectral and angular control over the emission properties will be possible. The approach focuses on the development of: i) new synthetic routes to achieve efficient nanophosphors, and ii) preparation and processing strategies, based on surface textures and colloidal scatterers, to attain large area optical nanostructures possessing photonic properties that will allow a precise control on the intensity, angular distribution and color quality of light emission. Results achieved within this project will provide significant advance both in the comprehension of fundamental phenomena as well as in the development of versatile solid-state lighting devices of optimized efficiency, aiming to overcome technical barriers and maximize performance. The projects outcome is twofold: a substantial expansion of the preparation of optical nanostructures to control light-mater interaction, and the practical realization of nanostructured light-emitting devices with unprecedented properties.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195386;657070;GRAFLEX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Graphene curvature, flexibility and reactivity control by means of external fields: theory and computer simulations;8/09/2015;7/09/2017;;"Graphene is a unique material with high potential for applications from high-tech to bio-tech. These capabilities are directly connected to graphene flexibility and electronic properties, as well as to the possibility of controlling them by chemical functionalization. Curvature related reactivity enhancement was shown, and curvature control has found several possible applications from H-storage and energy harvesting to biomed engineering. Thus, the control of graphene curvature is of high relevance.
The aim of GRAFLEX is to investigate the process of curvature control by means of external electric- and electromagnetic fields (EMF), and the consequent curvature-dependent interaction with H, specifically focusing on the physis- to chemi-sorption reversible conversion. EMF in the range of THz will be chosen, since coherent graphene vibrations at those frequencies correspond to the traveling nano-sized ripples producing a local dynamical modulation of the curvature.
To achieve this, we propose to use a state-of-the-art density functional (DF), DF perturbation, and trajectory based time dependent DF theories in combination with ab initio investigation of the kinetics and calculation of flexoelectricity response to the strain gradient in curved graphene.
Conducting the proposed research after carrier break will help the proponent to resume research activities and to train in 1)using the most advanced theoretical methods to investigate properties in graphene/hydrogen system; 2)observe time-resolved information to exploit curvature control process. The complementarity expertise of researchers at NANO@NEST group of multi-scale simulations and proponents extensive experience trajectory based chemical dynamics, kinetics and quantum chemistry, together with attractive working conditions, guarantee the feasibility of this challenging project. The experience gained by the proponent within GRAFLEX will change her carrier path to attain an independent position in academia in Europe";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195497;657716;RejuvenateBone;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Enhancing the regeneration of bone defects in elderly: Rejuvenation of bone microenvironment;10/04/2015;9/04/2017;;"Bone defects resulting from trauma, tumor resection and bone diseases represent one of the most pressing health problems in the aging European population. Current treatments of bone defects depend on a functional population of bone-forming (osteogenic cells) to mediate the process of bone regeneration. However during aging, the bone formation capacity decreases as a result of multiple interacting cell-intrinsic and cell-extrinsic mechanisms and the success of treatments in aged patients is in most cases limited. The aim of our project is to develop a new multidisciplinary approach to enhance the regeneration of bone defects in elderly, based on recent advances in cellular reprogramming and tissue engineering. We propose to investigate the extrinsic microenvironment components synthesized by young, embryonic-like osteogenic cells derived from human induced pluripotent stem cells, and test their potential to enhance the function of endogenous bone and vascular cells. We will focus our studies on the patients unable to benefit from the current therapies, due to advanced age and/or systemic conditions limiting their bone formation capacity. We will develop allogeneic, off-the-shelf bone tissue substitutes with the capacity to enhance the function of endogenous cell populations, and evaluate their safety and bone healing potential in preclinical models of bone repair. We hypothesize that ostegenic cells derived from reprogrammed adult/aged somatic cells can synthesize a rejuvenated, embryonic-like bone microenvironment with high regenerative capacity and enhance the bone healing processes mediated by aged endogenous cell populations.
Our studies will provide new understanding of extrinsic mechanisms governing bone cell biology during aging and open new therapeutic possibilities for the aged patients currently lacking successful outcomes. The developed bone substitutes will also provide a valuable new model for basic biology studies and translational research.";178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG;AT;;; 195563;658174;CREAM;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Control of Energy by Advanced Artificial Materials;1/04/2015;;;"The objective of the present project is to control the energy carried out by mechanical and electromagnetic waves by means of a new type of advanced artificial structures. To achieve this control resonant cavities for the simultaneous localization of elastic and electromagnetic waves will bedeveloped. The mentioned structures will be based on artificial anisotropic and inhomogeneous materials, designed by properly engineered periodic arrangements of scattering units.
The project aims to exploit the unusual properties of these complex structures for the localization of the energy carried out by mechanical and electromagnetic waves, offering in this way a new insight to the field of artificial materials (metamaterials), where less attention has been given to the problem of localization of waves, since it has focused efforts in the extraordinary propagation characteristics of waves along them (negative refraction, cloaking, transformation acoustics and electromagnetics, etc.).
The objectives of the project will be accomplished by the deep understanding of a new type of structures: Radial Wave Crystals (RWC), a special type of sonic and photonic crystals which present cylindrical or spherical symmetries.
It is well known that cylindrical shells of RWC present extraordinary resonant properties. However, their study has been slow given the difficulties found in their physical realization. In this proposal this feasibility will be explored, and also less restrictive versions of RWC will be seek, but trying to keep their extraordinary properties.
Finally, based on RWC a new type of optomechanical cavities will be investigated, by studying the electromagnetic and mechanical properties of these structures embedded in finite substrates. An iterative discussion with experimentalists at the IEMN (the host institution) will lead to a realistic proposal for the fabrication of an efficient optomechanical cavity based on inhomogeneous and anisotropic structures.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE I;FR;;; 195350;656886;SmartMammaCAD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Intelligent Automated System for detecting Diagnostically Challenging Breast Cancers;1/09/2015;31/08/2018;;"In this project, Dr. Ignacio Alvarez Illan proposes to develop a novel automated diagnosis system that supports the radiologist in the breast cancer diagnosis in Dynamic Contrast Enhance-Magnetic Resonance Imaging (DCE-MRI) by including critical components of the radiological work-flow such as motion compensation, segmentation and diagnosis of breast tumours. The expected results of this interdisciplinary project will definitely have applications and impact in the European society and its health and the overarching goals of the '2020 Vision for the European Research Area. Specifically, improving diagnosis of major diseases such as breast cancer is a research priority in the European Union.

The main goal and overall objective of this project is to develop computer aided diagnosis (CAD) methods, and image processing techniques to improve diagnostic accuracy and efficiency of cancerrelated breast lesions. Non-mass-enhancing lesions exhibit a heterogeneous appearance in breast MRI with high variations in kinetic characteristics and typical morphological parameters, and have a specificity and sensitivity much lower than mass-enhancing lesions. For this reason, new segmentation algorithms and kinetic parameters can be potentially used as an alternative to the methods for mass-enhanced lesions.

To develop and implement CAD methods and image processing techniques, three different research objectives are presented in this project. They include basic research, strategic research, applied research and transfer of knowledge: i) Develop non-rigid registration and segmentation techniques to incorporate spatial variations in temporal enhancement. ii) Develop kinetic feature descriptors to quantify significant differences between the benign and malignant lesions. iii) Develop and validate algorithms, interfaces and software implementation for real applications of CAD of breast cancer.";257191,2;257191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSIDAD DE GRANADA;ES;;; 195420;657261;TRICE QFT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;TRapped Ion Coherent Execution of Quantum Fourier Transform;1/04/2015;31/03/2017;;Quantum computers hold the promise to efficiently solve certain computational problems that would be intractable using conventional computers. The latter are not able to efficiently incorporate quantum phenomena arising with superposition of states or entanglement. In order to realize a large-scale quantum computer, it is imperative to have superior control over the efficiency and reliability of already available quantum operations. Trapped ions, being a scalable quantum system, envisage the experimental realization of a large-scale universal quantum computer. The proposed project will demonstrate a novel route to implement a Quantum Fourier Transform (QFT), a crucial component of many quantum algorithms, in a small-scale quantum information processor based on a string of singly charged ytterbium ions confined in a linear Paul trap. In presence of a magnetic field gradient-induced coupling, simultaneous interaction between all pairs of qubits will be exploited for efficient execution of quantum algorithms. Thus, instead of decomposing a given quantum algorithm into its smallest possible elementary constituents (1- and 2-qubit gates), multi-qubit conditional quantum dynamics will be used to implement a QFT. Experiment and theory will collaborate at all stages to streamline the project. New collaborations will be established allowing to combine the tremendous knowledge and expertise already existing in the field. The breakthroughs envisioned in the project are, to explore and implement simultaneous couplings between N 4 qubits allowing for efficient execution of quantum algorithms, and to implement a Quantum Fourier Transform with N 4 qubits pointing into the future capability of realizing a large number factorization using a quantum factoring algorithm. In addition, career development plans are proposed to assist the fellow acquire new skills enabling a high level of professional maturity and independence to lead a successful career in academia.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET SIEGEN;DE;;; 195334;656821;SEAGAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Multi-disciplinary Comparison of Fluid Venting from Gas Hydrate Systems on the Mediterranean and Brazilian Continental Margins over Glacial-Interglacial Timescales;30/04/2016;29/04/2019;;Gas hydrates are ice-like compounds that form within near-seabed sediments on continental margins, concentrating greenhouse gases (mainly methane) within what is estimated to be the largest reserve of hydrocarbons on Earth. The stability of this frozen sub-oceanic reservoir is sensitive to changes in sea-level and temperature over time, but also to the poorly understood dynamics of chimney-like structures observed to vent gas to the oceans. An understanding of gas venting from hydrates over time is of scientific and social relevance, due to potential impacts on global carbon budgets, regional geohazard assessments and future energy resources. SEAGAS is the first project to propose a comparative analysis of gas hydrate systems on continental margins that have experienced differing forms of glacial-interglacial climate forcing: an open ocean (the South Atlantic) and a semi-enclosed sea (the Mediterranean). The project will perform numerical modeling of changes in gas hydrate stability on both margins, to guide analyses of marine geophysical, geological and geochemical datasets held by the outgoing and return hosts, as well as of data to be obtained during a joint acquisition campaign to the Nile fan. SEAGAS leverages ongoing high-level research programmes by the outgoing and return hosts, which offer multi-disciplinary expertise and datasets, as well as access to ship-time. The key training objective is for the researcher to acquire new skills in marine geochemical concepts and methods with the Brazilian host, in order to broaden his existing competencies (and those of the French host) in marine geophysics and geology. SEAGAS has the strategic objective of consolidating a nascent collaboration between the outgoing and return hosts, with strong potential for further collaborations. SEAGAS will thus make an impact on European research excellence and competitiveness while resulting in a diversification of competencies in a field of strategic interest for the ERA.;238410;238410;H2020-MSCA-IF-2014;MSCA-IF-GF;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195382;657042;PINQUAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Polaritons IN the QUAntum Regime (PINQUAR);1/05/2015;30/04/2017;;Semiconductor optical microcavities host hybrid light-matter quasi-particles known as polaritons, formed by strong coupling between cavity photons and quantum well excitons. Polaritons are interacting bosons, which above a critical density may condense into a single quantum state. Polariton condensates have enabled fascinating discoveries, yet state of the art experiments remain within the mean-field limit. This means that the physics is governed by a large number of polaritons per mode. We propose to develop polariton systems operating in the quantum regime, where the physics is governed by single or few polaritons. Enhancing the polariton non-linearity is a pre-requisite for accessing the quantum regime. Therefore, our proposal begins with studies of extreme non-linear optical phenomena still within the mean-field limit. In particular, we will study bifurcations, exceptional points, and spin-squeezing. Next, we will enter the quantum regime by exploiting interference effects between coupled polariton modes to generate non-classical light via an effect known as unconventional photon blockade. Our final objective is to demonstrate the conventional photon blockade, wherein a single photon in a highly nonlinear cavity blocks the entrance of a second one. Polaritons IN the QUAntum Regime (PINQUAR) will enable previously inaccessible fundamental studies and applications where photons can be emitted one-by-one, non-classical photon statistics can be engineered in time and energy, and quantum simulations can be performed in a controlled solid-state platform suitable for all-optical integrated circuits.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195391;657111;CompositeSPTphases;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Composite-particle approach to Symmetry Protected Topological Phases;1/04/2015;31/03/2017;;The sum being greater than its parts is a common theme in condensed matter physics. Materials made of large numbers of simple constituents often exhibit intriguing and markedly distinct phases of matter with properties very different from any of the individual constituents. Understanding the possible phases of matter and identifying them in real materials is the central focus of this branch of physics. Roughly speaking, two categories of phases of matter exist--- conventional phases which show a geometrical pattern of order, and topological phases, where the order is more elusive and related to topological concepts. In the past three decades, topological phases have attracted a large amount of interest due to their tendency to exhibit highly robust quantum phenomena which has various applications in quantum engineering and metrology. The current frontier in the field aims at understanding the variety of novel topological phases which arise when some extra symmetries, such as time reversal, are not allowed to be broken. In this project we explore this new type of phase using the concept of composite particles --- an idea which has been extremely useful in previous studies of topological matter, but has not been applied in the symmetry-protected context previously. The fundamental idea behind our approach is to view symmetry protected topological (SPT) phases of spin/electron systems as conventional ferromagnets/superconductors/metals of composite objects. Besides its conceptual importance, such an approach will allow us to utilize our knowledge of conventional phases in the context of SPT phases and also derive microscopic models which realize these states of matter. It will thus increase the chance of discovering new SPT phases in nature.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195389;657088;MRTGS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechanical regulation of tissue growth and signalling;1/01/2016;31/12/2017;;"The control of tissue size and morphology is a fundamental problem that is remarkably ill understood. Although extensive research has focussed on the genetic and biochemical control of tissue growth, significantly less attention has been paid to the mechanical aspect of growth regulation, even though ample evidence indicates that any deformation or shape change is, to some degree, a result of force acting on a mass. Unravelling the basis of the mechanical-biochemical co-regulation in tissue growth control will not only increase our understanding of organismal development but also potentially represent a novel therapeutic target in growth-related diseases such as cancer. With this in mind, I aim to address two central questions:
1) How do mechanical stresses generated by growing tissues impact signalling networks to modulate tissue growth and morphology?
2) What is the function of in situ mechanical force on normal tissue growth and 3D architecture?
Using the Drosophila wing disc as the model tissue, I will employ a combinatorial biophysical, molecular, genetic and computational modelling approach to address the proposed questions. With a novel tissue stretching and compression device, I will initially identify key signalling events mediating the growth responses downstream of mechanical force. In parallel, by individually altering the genetic or the mechanical properties of the system, I will address co-regulation between mechanics and tissue growth. My research will lay the foundations for our understanding of tissue growth control by mechanical forces - a finding that may ultimately help to design novel treatment strategies for cancer. The classical approach to restrain cell growth involves targeting of the underlying genetic defect; however it might be more advantageous to apply physical therapy instead in situations where biochemical treatments do not suffice.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195295;656625;CHOCOLATE;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;CHanges Of CO2 Levels during pAst and fuTure intErglacials;15/10/2015;14/10/2017;;"The concentration of carbon dioxide (CO2) in the atmosphere depends on carbon cycle processes, i.e. sources and sinks of carbon. The future evolution of the carbon sinks is not well known, which inhibits robust quantification of future atmospheric CO2 concentration and the resulting climate change. Understanding warm past periods is essential to constrain climate models and accurately predict future changes. During the last million years, warmer periods, called interglacials, happened every ~100,000 years. CO2 levels measured in interglacials before the mid-Bruhnes event (MBE), a large climate shift taking place ~430,000 years ago, are lower than the CO2 in interglacials after the MBE. The cause for this drastic evolution is still unexplained, resulting in uncertainty in the carbon cycle response to global warming.
To resolve that issue, we propose to combine data and model simulations including new key processes. We suggest that a major mechanism was a slower circulation during interglacials before the MBE, resulting in more ocean carbon storage and lower atmospheric CO2. We also hypothesize that sea-level changes played a considerable role by altering carbon sinks from land vegetation and shallowing ocean carbonate sedimentation. We will include these mechanisms in a state-of-the-art climate model applicable to long timescales, and compare its modified behaviour with paleoclimate data and more complex models used for projections. This will provide a step change in our understanding of the impact of ocean circulation and sea-level changes on the carbon cycle. It will benefit the European and international scientific community by shedding new light on these processes, and by setting the basis to include these new mechanisms in climate models used for projections. The excellence of the experienced researcher in carbon cycle modelling combined with the expertise in ocean modelling and paleoclimate data from the host institution will ensure the success of this project.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit de Bordeaux;FR;;; 195283;656522;EARLYSTART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Short and long-term consequences of the early environment;1/10/2015;30/09/2017;;The early developmental period is very sensitive to disturbances. Parents are known to shape the early environment of their offspring through physiological and behavioural modifications. In this project, I am going to investigate what are the short- and long-term consequences of different family scenarios in development and fitness. For that, I will consider female promiscuity as a modifier of the early environment because (a) promiscuous females are more exploratory, more active, and thus, less nest-attending, and (b) males paired with promiscuous females decrease their paternal input. Therefore, offspring raised under such conditions might reach independence with a compromised body condition, decreasing their chances to survive until reproductive age. Moreover, I will explore whether females are able to compensate for the losses of paternal effort by increasing their own breeding effort, or whether chicks can compensate for the reductions in parental support. For that I will use two approaches: an empirical study with spotless starlings where I will focus on both the short- and long-term effects of promiscuity for fitness of mothers and offspring (survival and reproduction), and a comparative analysis where I will investigate the short-term effects of different breeding systems on the fitness of females and offspring. Both approaches will be integrated following a causal framework.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit Paris-Sud;FR;;; 195618;658520;PATOX;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of pyrrolizidine alkaloid detection methods for the assessment of food contamination and impact on human and animal health;18/01/2016;17/01/2018;;Pyrrolizidine alkaloids are more than 600 individual compounds that are hazardous for animals and humans if ingested. The 3% of the flowering plants produce these type of molecules and grow as weeds in agricultural production systems throughout the world where they can contaminate commonly consumed foods (eg. grain, milk, meat, eggs, honey, pollen). Chronic exposure to low concentrations of these alkaloids can be the cause of progressive, chronic disease (hepatic damage, vascular obstructive disease, and cancer) that may be difficult to attribute to their presence in food. The 2007 statement from the European Food Safety Authority calls to generate more quantitative data sets on pyrrolizidine alkaloids levels in milk and honey, and to determine which PA plants and/or marker PA need to be considered relevant in animal feed. In the same direction, this Authority pointed in 2011 that toxicological data for pyrrolizidine alkaloids commonly found in honey was needed. Even though some countries have regulated the concentration of pyrrolizidine alkaloids in herbs used in traditional medicines, a general European legislation regulating the concentrations of these alkaloids in food is still pending. The present project propose the use of state of the art technology (UPLC-Qtof-MS, antibody microarrays) to better understand the distribution of pyrrolizidine alkaloids producing plants in relation to food content, and determine the incidence of exposure to these molecules in humans and animals. The results will impact several levels of society, the scientific results will provide science legal advisors with solid data to better inform law makers in the regulation of pyrrolizidine alkaloids in food, society will gain knowledge on the exposure to this type of molecules and on hazardous dietary habits, and food industry will benefit through the introduction of practices to avoid pyrrolizidine alkaloids containing components in food.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE QUEEN'S UNIVERSITY OF BELFAST;UK;;; 195357;656917;River-HMV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;River hydraulics, morphology, and vegetation: A case for improved knowledge and numerical model capabilities;1/10/2015;30/09/2017;;The interdisciplinary knowledge and ability for river managers to effectively predict flood risks, restore rivers, and assess future alterations are currently restricted to the limited understanding of how river hydraulics, morphology, and vegetation alter a rivers planform, effect sediment mobility, and control the surrounding habitats. To improve this knowledge and capabilities, this research seeks to i) use physical model flume experiments to quantify the hydraulic, morphologic, and vegetation interactions of a braided channel as well as investigate the use of manipulated channel avulsion as an innovative method to increase a rivers floodplain conveyance, ii) to quantify the accuracy of a cutting-edge numerical models simulations, and iii) to improve the numerical models functionality. Through increased knowledge, improved model capabilities, and potentially identifying a new technique to increase a degraded rivers floodplain dynamics, this research can improve the efficacy of river managers around the world. In particular, Europe could utilize the contributions of this research to help meet the ecological-morphological aspects of the Water Framework Directives and Flood Directives and to restore many of the heavily altered rivers of the European Alps.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI TRENTO;IT;;; 195351;656889;GEOTeCH;SIGNED;"H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-03-2014;H2020;Geothermal Technology for conomic Cooling and Heating;1/05/2015;30/04/2019;;"The Drilling technology that is currently used for installation of vertical borehole heat exchangers requires capital-intensive equipment that is expensive to mobilize, leads to deteriorated working conditions and requires experienced teams of specialist operatives. Drilling operations also often require significant quantities of drinking quality water and dispose of dirty water and mud. GEOTCH will employ a different drilling concept that is based on dry auger methods that requires less capital-intensive equipment, enhances safety and avoids the environmental risks, complexity and costs of dealing with water supplies and contaminated waste.
Another key concept of GEOTCH will be a better integration between heat exchange elements during installation by developing an innovative heat exchanger allowing to achieve high levels of thermal performance with low pressure loss. This device employs a co-axial configuration and spiral fluid flow pathways to achieve low thermal resistance compared to conventional U-tube devices.
Furthermore, GEOTCH aims to implement cost-effective geothermal systems by alleviating the costs associated with drilling boreholes in large size buildings. The GEOTCHs approach seeks the maximum use of the foundation structures that are otherwise required, exclusively, for structural and geotechnical purposes in tertiary buildings. Foundation structures such as piles, screen walls and basement slabs will become effective geothermal heat exchangers in GEOTCH.
GEOTCH will develop optimized hybrid solutions that will integrate the different geothermal systems in small and large buildings market. The optimization of geothermal system operation will be achieved with the Energy Management System and the development of a dual source heat pump capable of making optimal use of ground and/or air environmental heat sources. The GEOTCHs geothermal heating and cooling standard will be more attractive to design professionals and construction companies.";9025458,75;7136662,88;H2020-LCE-2014-2;IA;SOLINTEL M&P SL;ES;"DE MONTFORT UNIVERSITY;ARMENGOL & ROS CONSULTORS I ASSOCIATS;FUNDACION TECNALIA RESEARCH & INNOVATION;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;D'APPOLONIA SPA;UNIVERSITA DEGLI STUDI DI PADOVA;CONRAD STANEN BV;UNIVERSITY OF LEEDS;GROENHOLLAND GEO ENERGIESYSTEMEN BV;COMSA INSTALACIONES Y SISTEMAS INDUSTRIALES SL;STUWA KONRAD STUKERJURGEN GMBH;UNIVERSITAT POLITECNICA DE VALENCIA;GEOTHEX B.V.;KATHOLIEKE UNIVERSITEIT LEUVEN;HIREF SPA";"UK;ES;IT;NL;DE;BE"; 195429;657304;GlidArc;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards a fundamental understanding of a gliding arc discharge for the purpose of greenhouse gas conversion into value-added chemicals;22/06/2015;21/06/2017;;Global climate change due to anthropogenic greenhouse gas emissions is a growing concern. The conversion of greenhouse gases (mainly CO2, CH4) to value-added chemicals or renewable fuels is an effective strategy to reduce these emissions and an interesting process both from economic and ecological point of view. A gliding arc (GlidArc) plasma offers unique perspectives for activating inert molecules at mild conditions and allows the greenhouse gas conversion with limited energy cost. A GlidArc is, however, very complex and poorly understood. Therefore, this project intends to obtain more fundamental insight in the plasma-mechanisms of the GlidArc for greenhouse gas conversion, by means of extensive modeling, validated by experimental diagnostics. First, the chemical kinetics in the GlidArc for greenhouse gas conversion will be studied. Second, this plasma chemistry will be incorporated in a coupled magnetohydrodynamics (MHD) - kinetics model to study the spatial and temporal plasma properties. The model will be validated by experiments, to be carried out during the secondment. Furthermore, the effects of various operating parameters, such as the CH4/CO2 ratio, the discharge power and the gas flow rates, on the gas conversion, the yields of the formed products and on the energy efficiency will be analyzed, in order to predict which conditions give rise to the highest and most energy-efficient conversion. This project is very interdisciplinary, including chemistry, physics, chemical engineering, mathematics and computer modeling, with application in environmental science and sustainable chemistry. Definitely it will extend the applicants skills in plasma modeling to a much broader field, with new applications, and enhance his creative and innovative potential by advanced training in an international research environment.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT ANTWERPEN;BE;;; 195371;656995;RESILIENCE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;RESILIENT2: A novel thermosensory module at the interface of temperature and defense signaling;1/09/2015;31/08/2017;;The proposed project aims to define the molecular framework at the interface of plant immunity and temperature signaling pathways. To sense and respond to external environmental cues is critical for adaptation of plants to local environments. Temperature is a key seasonal variable controlling plant processes like developmental decisions as well as outcomes of plant-pathogen interactions. Elevated temperatures cause reduced resistance to pathogens resulting in enhanced susceptibility. Climate change, most importantly increasing global temperatures, poses a severe threat to agriculture and biodiversity. Though known for long, the phenomenon of temperature induced disease susceptibility is not sufficiently well understood at the molecular level. A unique Arabidopsis mutant resilient2 (res2) with temperature resilient defense response has been identified through a novel forward genetic screen. The res2 mutant also displays defective temperature sensing phenotypes suggesting that RES2 encodes a novel thermosensory molecule that modulate plant defense. I will systematically characterize the res2 mutant to define the molecular mechanism by which RES2 regulates temperature sensing and plant immunity. Findings of this study will answer the longstanding fundamental biology question of how environmental signals are integrated, especially the molecular basis for temperature induced defense breakdown. This will contribute to developing climate resilient crops in the wake of unprecedented increase in temperature as a result of global climate change.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JOHN INNES CENTRE;UK;;; 195482;657639;WORMTUMORS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Worm power: Can helminths modify the development of colorectal cancer?;1/08/2015;31/07/2018;;The incidence of cancer is significantly lower in developing areas such as Africa, than in the Western world. These developing regions have a high incidence of helminth infection, which can protect against immune-mediated diseases and are currently being successfully used within clinical trials as novel therapeutics to treat inflammatory bowel disease. As Africa develops, lifestyle and dietary changes will collide with the presence of chronic infectious disease, such as gastrointestinal helminths, increasing the risk of colorectal cancer. The intrinsic immune-suppressive nature of helminth infections is known to be detrimental to the generation of immune responses to other infections and vaccination, and may also impair anti-tumor responses in vivo. We have recently found that local exposure to helminth products can result in increased tumor cell growth and metastasis. Currently, it is unknown how helminth modulation of immunity influences colorectal cancer incidence and progression. This fellowship proposal will make use of an inflammation-associated and spontaneous model of colorectal cancer to test the impact of live helminth infection and exposure to helminth excretory/secretory products on tumor development. It will further dissect the impact of helminth exposure on the innate and adaptive anti-tumor immune response, using multi-colour flow cytometry and cell-specific knockout mice. Furthermore, rescue of an impact of helminth exposure on anti-tumor immunity will be attempted by in vivo cell transfer. This fellowship aims to increase our understanding of how helminth infection contributes to tumor development and may lead to the design of novel therapeutics to improve tumor immunity.;203200,2;203200,2;H2020-MSCA-IF-2014;MSCA-IF-GF;CARDIFF UNIVERSITY;UK;;; 195335;656822;ChloroQuality;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dissecting chloroplast protein quality control specificity for rational plant reprogramming;1/01/2016;31/12/2017;;Improving food quality, crop productivity and plant resistance to stresses are major demands of Europes society and economy. Plants are sessile organisms that have developed very flexible strategies to cope with adverse environmental conditions as heat, cold, drought and salt stress. These stresses cause protein misfolding and aggregation resulting in plant damage/death and productivity losses. Recycling of damaged proteins is achieved by the action of molecular chaperones. But when recycling is not possible, toxic aggregated proteins have to be degraded by the action of proteases to avoid cellular damage. Chaperones and proteases act coordinately and constitute the protein quality control system that is essential for plant survival. In plant chloroplasts, the chaperone Hsp70 is known to posttranslationally regulate important processes like photosynthesis. It is known that the specificity of Hsp70 is determined by its J-protein partners, adaptors that recognize unfolded substrates and transfer them to the chaperone for refolding. However, little is known about the target proteins of Hsp70, such that there is a large lack of information about how chloroplastic enzymes are regulated at protein levels. This knowledge is crucial for rational engineering of specific molecular pathways and plant fitness improvement. The ability to specifically alter plant metabolism without undesirable effects is a fundamental demand of European society and addresses current concerns about transgenic plants. This proposal aims to cover this gap by discovering and validating interactors of chloroplastic J-proteins. The strong background of the applicant in protein quality control and the expertise in chloroplast biology of the receiving group will synergistically contribute to shed light on the chloroplast signaling network. In addition, this project aims to develop the candidate into an independent scientist and open his own line of investigation.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195319;656763;GTHREG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Differential regulation of gonadotropins;1/09/2015;31/08/2017;;As wild fish stocks are dwindling, aquaculture is increasingly relied upon to supply the growing world demand for fish. However aquaculture operations are largely impeded by our limited understanding of the mechanisms that control reproduction in farmed fish. The gonadotropins LH, FSH and their main stimulator GnRH are key regulators of the reproductive axis in vertebrates. We propose to utilize the unique anatomical traits and rich toolbox of the zebrafish model to dissect the mechanisms driving the differential regulation of LH and FSH. We will adopt a transgenic approach combined with state-of-the-art live imaging techniques to investigate the intricate interplay between GnRH and gonadotropes in the teleost pituitary. Taking advantage of the unique anatomy of the zebrafish, in which LH and FSH are discreet cell types, and the unique expertise of Mollards lab in cellular in vivo imaging of the hypothalamus-pituitary tract, we will investigate the functional role of both the circulation and direct contacts (GnRH terminals which directly abut onto gonadotropes) in delivering GnRH signals to target cells and reveal how these signals are interpreted by the gonadotropes to differentially activate LH or FSH cells. The results of the project are expected to provide new insights into the evolution and function of gonadotropin regulation in vertebrates and yield new approaches to control and manipulate the reproductive axis of commercially important species.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195405;657192;HotPaNTS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hot-spots of Phosphorus and Nitrogen delivery in Time and Space in agricultural catchments;1/01/2016;31/12/2017;;Growing food demand exacerbates negative impacts of agriculture on the environment including diffuse nutrient losses from agricultural land to surface and groundwaters causing their eutrophication. The research will evaluate a robust monitoring method of detecting diffuse pollution in space and time in agricultural catchments based on in situ fluorescence sensors. Tangible advantages of the fluorescence sensors: in situ deployment, low cost, real-time measurements, mobility within the catchment, sensitivity and reliability, will be evaluated against potential limitations from quenching effects. This comprehensive evaluation is possible thanks to the hosts unique expertise and role as a coordinator of the Swedish monitoring programme with access to the monitoring catchments, covering a range of agronomic and environmental conditions. Once tested over hot-spots and hot-moments of nutrient delivery, the method could offer an alternative and/or complementary monitoring approach to the existing methodologies of low-frequency and fixed-location nutrient sampling. The tool will improve targeting nutrient sources and mitigation measures to the locations in which they will bring the largest economical, societal and environmental benefits and in turn will help to achieve the aims of the EU Water Framework Directive.;173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SVERIGES LANTBRUKSUNIVERSITET;SE;;; 195548;658079;EMMA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;European Multimodal Metaphor in Advertising;5/10/2015;4/10/2017;;Metaphor and metonymy are key tools in communication, particularly when abstract ideas or emotions are discussed. While extant literature addresses metaphor in language and images, little has dealt with the combination of metaphor and metonymy in the multimodal context of advertising, where they play a key role. The EMMA fellowship aims to redress this by testing figurative complexity and emotions, the impact of these on comprehension, accuracy of interpretation and advertising effectiveness. It involves an interdisciplinary study that combines cognitive and physiological psychology with linguistic and marketing interpretations. A mixed-methods approach of lab experiments and qualitative inquiry will assess the speed and depth of comprehension, the perceived appeal, and the physiological effect of static and video advertisements on participants from three linguistic and cultural backgrounds (English, Spanish, and Chinese). If advertisers, charities and NGOs target, and are sensitive to, linguistic and cultural differences in metaphors, local and international communities can benefit from specific, appropriate and ethical advertising. The fellow will benefit from involvement in a cutting-edge study and secondments both at a leading research institute in The Netherlands an two advertising companies in Spain.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195376;657016;FEEC discretizations;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structure-preserving discretization of hierarchically-structured rotating covariant shallow-water equations using finite element exterior calculus;1/04/2016;31/03/2018;;"Accurate and reliable simulations of weather, ocean and climate require computational models that result from structure-preserving e.g. mass or energy conserving discretizations of the equations of geophysical fluid dynamics (GFD). This research project aims to derive, implement and evaluate various structure-preserving discretizations (of different order of accuracy) of the nonlinear shallow-water equations, which are suitable for weather/ocean/climate applications. The derivations will rely on a novel form of covariant equations of GFD that I have formulated using Differential Geometry, in which the equations are split into metric-free (topological) and metric-dependent parts. Based on the systematic discretization I have introduced for the split linear shallow-water equations, this project intends to extend this approach also to the split nonlinear case and to derive structure-preserving discretizations that preserve in the discrete case, too, the splitting into topological and metric terms. As the topological terms require less mathematical structure, we expect an advantage in terms of easiness of discretization and efficiency of implementation.
To derive corresponding discrete equations, we apply finite element exterior calculus (FEEC) as recently Cotter and Thuburn, whose resulting discretizations of conventional covariant nonlinear shallow-water equations fulfil many desirable properties for geophysical applications. Moreover, compared to the split form I proposed, their discrete equations show a similar, however not identical, structure. We study the differences and use their derivations as guideline for ours. To implement and test the various models, we use the software libraries Firedrake and FEniCS. Besides a general discretization recipe to derive structure-preserving models, this project will provide open-source software which will be of practical use for the geophysical model community.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195280;656511;KSHV QTV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Identification of novel KSHV immune evasion mechanisms using a quantitative temporal viromics analysis;15/06/2015;14/06/2017;;Kaposis Sarcoma-associated herpesvirus, or human herpesvirus 8, is an important cause of morbidity and mortality, causing tumors in immunosuppressed patients, in particular those with AIDS. Like other herpesviruses, KSHV has evolved numerous mechanisms of escape from both the innate and adaptive host immune response. These immune evasion strategies facilitate the viruss oncogenic potential and contribute to its pathogenesis. Beyond immune modulation, many viral proteins interact with components of the cellular proteome to enable viral replication. However, the complete array of such proteins, their kinetics and fate in both latent and lytic phase of viral infection has never been determined. Here, I propose an unbiased proteomic approach to analyze the expression kinetics of the KSHV proteome in the context of cellular infection, and explore how host cell surface and cytoplasmic proteins are regulated by this virus throughout its infection cycle. To achieve this goal I will resolve both the host cell and the viral proteome in primary endothelial cells and B cells using the recently developed technique, quantitative temporal viromics. This novel approach is interdisciplinary, incorporating virology, immunology, cell biology, state-of-the-art proteomics and has been successfully applied to identify novel markers of latent HCMV infection as well as novel immunomodulation strategies. The proposed study will allow a temporal analysis of how the host and viral proteome change upon latent as well as lytic KSHV infection. Newly discovered viral targets, such as ligands for Natural killer (NK) or cytotoxic T cells will be validated and investigated using biochemical and virological methods available in the host (Lehner) lab. The results of this study will therefore provide unique insight into the virus-host interactions and uncover novel viral strategies of the host immune system. The identified proteins may ultimately serve as novel targets for therapeutic interventions.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195342;656848;NETIA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neolithic textiles and clothing industries in the Aegean;1/09/2015;31/08/2017;;"The NETIA research project explores the textile arts and crafts of the early agricultural communities in the Aegean (6500-3300 BCE). The scope of this interdisciplinary project is to examine the origins and the first stages of textile crafts and other related technologies for coverage, protection and decoration of the human body. It focuses on raw materials, tools, technologies and textile design but aims towards an understanding of spatial organization of crafts and its impact on the economy, social structure of ancient societies and their natural environment.
The main data collection will be carried out primarily within the borders of the modern Greek state, while comparisons will be made with Neolithic evidence from the Balkan countries and Anatolia. Since industrial activities in the Neolithic societies are closely related to the earliest systematic exploitation of natural resources and the domestication of wild species (plants and animals) first attested in the Near East, this synthesis, combined with other archaeological data, will contribute to an overall understanding of innovations, cultural exchange and population mobility in contemporary Neolithic Europe.
The project is hosted by the University of Copenhagens Centre for Textile Research (CTR), a highly specialized center for textile studies with rich activity and international collaborations providing optimal training for the project's purposes, and by the TOPOI Excellence cluster Textile Revolution in FU Berlin. The results will be presented in a series of academic and popular outreach activities and will supply material for educational and industrial applications.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;KOBENHAVNS UNIVERSITET;DK;;; 195603;658405;HYPOXFLU;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;[18F]Fluorination of alkylCF3 and alkylCF2CF3 chains-Application to hypoxia biomarkers for PET imaging.;16/03/2015;15/03/2017;;The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195367;656984;MINDFLY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mid-IR ultrabroadbaNd thulium-doped Fiber Laser sYstems;1/03/2016;28/02/2018;;"The aim of the proposed project is to develop novel configurations of the stable ultra-fast high power thulium-doped fibre laser systems mode-locked with carbon nanomaterials operating at ~2?m offering unique tool for micromachining. The Tm-doped fibre laser, with remarkable output parameters, will be used to obtain the ultra-broad supercontinuum generation in Mid-IR wavelength band extending beyond 3-9 ?m. The MINDFLY project outputs will be relevant to the EU photonics industry through offering new cost-efficient technologies for stable, low-noise, ultra-high-speed, high-power ultrabroadband sources of light at Mid-IR with lower power consumption (~50%). The products transformed from the MINDFLY outputs will contribute to the enhancement of EU scientific excellence. In particular, the success of the project will lead to a number of disruptive innovations in photonics with potential application in medicine (including cancer diagnostics and optical coherence tomography), environmental sensing, optical frequency standards, and laser location services.
The Fellow Dr. Maria Chernysheva will be trained in the fast growing field of science, technology and industrial applications of fibre lasers and nonlinear optics, receiving access to a unique training experience at the host and secondment organizations to become a rare asset to European research.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195374;657004;OATP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Operator algebraic approach to topological phases;1/09/2015;31/08/2018;;"Topologically ordered phases are a new state of matter, discovered only around the late '80s. In recent years interest in such states has sparked, one of the reasons being applications to topological quantum computing: the topological properties make the state robust against perturbations, making them ideal components in an environment where (thermal or other) noise is one's biggest enemy. By now there is a plethora of examples of topologically ordered states, whose only unifying feature seems to be that they do not fall into the Landau theory of phases. Although there are many examples, the mathematical framework to rigorously study such systems is less clear, in particular if one wants to consider both so-called long range entangled phases and symmetry protected phases. The goal of this project is to tackle this problem.

The approach that is proposed is to use operator algebraic methods to focus on the algebraic properties of the observables in such systems. This approach has proved successful in algebraic quantum field theory. Using this attack the aim is to find tools to classify the different topological phases, and in particular find methods that are applicable a wide class of models, despite looking very different at first sight. These ideas will be tested on the wide range of topological systems that is available. The focus in this project is on stability properties on the one hand, in particular for invariants of topological phases, and the study of boundary theories on the other hand.";257860,8;257860,8;H2020-MSCA-IF-2014;MSCA-IF-GF;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;DE;;; 195336;656824;Molmechindividuality;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular mechanisms of neuronal connectivity - the synaptic code for variability and stereotypy;1/09/2016;31/08/2018;;Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape specificity in connectivity and it is highly elusive what promotes variability in synaptic connectivity and whether this is behaviourally relevant. To work on these questions I have chosen the Drosophila olfactory system, which is well-defined both on the levels of circuitry and behaviour and as such well-suited to answer these question. Furthermore, from the perspective of circuitry, it is particularly appropriate as it is comprised of both deterministic and non-deterministic synaptic connectivity. In a first step to tackle the question, I will perform a screen to identify genes shaping deterministic and non-deterministic neural connectivity. In parallel, I will investigate olfactory behavioural variability in the fly and correlate this to circuitry variations on the morphological, synaptic and electrophysiological level. After identifying genes that are important for connectivity and correlating circuit to behavioural variability, I aim to modify circuit variability to alter behaviour.;171684;171684;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FREIE UNIVERSITAET BERLIN;DE;VIB;BE; 195414;657239;Neurostella;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolutionary and developmental origin of the nervous system;1/03/2016;;;Little is known about the genetic and developmental mechanisms that led to the evolution of the nervous system in the ancestors of eumetazoans. We plan to address the issue by studying a basal metazoan - the cnidarian Nematostella vectensis. The cnidarians are a sister group to bilaterians and possess a surprising complexity of genetic network, yet a relatively simple overall morphology including a diffuse nervous system. By studying the neural progenitors, we aim to address the problem from a developmental point of view. We propose to employ the state-of-the-art technology (transcriptome sequencing, in vivo imaging, transgenesis) in order to gain insight into the molecular characteristics of neural progenitors of Nematostella and to understand how the different populations of neural progenitors relate to neuronal diversity present in Nematostella. We will also analyse the function of a neural progenitor marker SoxB2, among others, in order to determine the role in the genetic hierarchy of the formation of the first nervous systems. Last, we will perform a comparative analysis of Nematostella neural progenitor make up with other cnidarians and bilaterians. This will elucidate the common and distinct features of cnidarian and bilateral nervous systems, which in turn will enable us to reconstruct the common ancestor.;178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195320;656767;TEMPEA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Temporality of permanence material and socio-spatial practices in African urbanism;14/09/2015;13/05/2018;;"The constructed materiality of African urbanism can be seen in buildings and the urban layout, especially when they aspire to permanence by building in stone. These built environments have mostly been analysed through the rather static lens of individual periods and social forces, resulting in uniformly interpreted organic growth (for pre-colonial periods), or as in stages of progress towards the fulfilment of a grand master plan (predominantly in the colonial and post-colonial era). This project seeks to explore the social temporality of African urbanism against the context of its material complements from the perspectives of a range of social and human sciences, in order to obtain a dynamic picture from before to after the colonial era. I aim to provide analyses relevant to the ever more pressing issues of urban ethnic/social coexistence and the implications of urban development.
I would like to extend my research on material expression and change in urban Swahili archaeology, and incorporate aspects of sociology (living in neighbourhoods in densely populated environments), history (representations and accounts of past experience) and social anthropology (the meanings of space). I will study the spatial materiality of African cities, as it is demonstrated in their layout and in the organisation of buildings, looking at how these urban patterns are produced, used and continually altered, and how a 'building heritage' emerges from these. My aim is to derive how this influences the social life of inhabitants and visitors, and how it in turn induces ongoing processes of change in material representations. First phase of the project is to be undertaken at the Centre of African Studies, University of Basel, Switzerland, which can provide me with excellent support in African social studies. In the 2nd phase at Uppsala University, Sweden, under the supervision of Professor Paul Lane, I will focus on the implications for the Swahili coast and African archaeology.";233111,6;233111,6;H2020-MSCA-IF-2014;MSCA-IF-GF;Uppsala universitet;SE;;; 195467;657539;STARMAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structured Training and Advanced Research in Marine Active Structures;1/05/2016;30/04/2018;;In the last 25 years the total amount of marine trade has nearly doubled. In the same period the container trade has undergone a tenfold increase, making the container fleet the fastest growing fleet at present. With 80% of total EU trade being transported by sea, the maritime transport is of the greatest importance to the EU. The increasing demand in container transportation is met by use of more containerships. Such ships with large bow and stern flares and fine underwater hull are severely hit by an effect known as parametric rolling. Accidents including container loss and vessel structural damage are reported from all around the world. Capsizing could be regarded as a rare event, but the consequences of such event are fatal (loss of the ship and the crew). Agencies, classification societies and the public are showing more and more interests in increasing the safety of large container ships. STARMAS is a highly interdisciplinary integrated research and training programme focused on the application of novel active control methods to increase safety, energy efficiency and quality of life at sea of the 21st century maritime transport. The problem of ship roll on rough seas will be tackled using novel active roll control methodologies. Bi-directional transfer of knowledge and cross-fertilisation between traditionally detached engineering disciplines will be unlocked, utilising a unique research approach to enduring engineering problems related to sea keeping, survival rate, and energy efficiency of marine vessels. The programme will boost the career prospects, increase employability and widen the set of skills of the experienced researcher. The training and research will predominately take place within the academic sector, at the Faculty of Mechanical Engineering and Naval Architecture (FAMENA). The researcher will also benefit from secondments to the non-academic partner Bureau Veritas, Paris, (BV) facilitating an inter-sectoral transfer of knowledge.;158010;158010;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SVEUCILISTE U ZAGREBU, FAKULTET STROJARSTVA I BRODOGRADNJE;HR;;; 195267;656437;STEELANOL;SIGNED;"H2020-EU.3.3.3.1.;H2020-EU.3.;H2020-EU.3.3.;H2020-EU.3.3.3.";LCE-12-2014;H2020;Production of sustainable, advanced bio-ethANOL through an innovative gas-fermentation process using exhaust gases emitted in the STEEL industry;1/05/2015;31/10/2018;;"The proposed STEELANOL project is based on producing bioethanol via an innovative gas fermentation process using exhaust gases emitted by the steel industry. The proposal addresses the specific topic Demonstrating advanced biofuel technologies (LCE-12 2014), under the call for competitive low-carbon energy in Horizon2020.

The BF/BOF gaseous emissions are an unavoidable residue from the steelmaking process and are currently used for electricity production or being flared. Nevertheless, they can be advantageously used to produce bioethanol, thereby reducing the usage of fossil fuel molecules and thus significantly reducing GHG emissions. The bio-ethanol production would have a GHG impact that is over 65% lower compared to oil derived fuels STEELANOLs main objective is to demonstrate the cost-effective production of sustainable bioethanol, with the purpose of assessing the valorisation of this ethanol biofuel as a fuel derivative for the transport sector. A demonstration plant of approximately 25,000 tons/ethanol per year will be built; the first of its kind in Europe, and the largest facility built to date utilizing this technology globally. ArcelorMittal is the lead partner of this project and proposal. The gas fermentation technology will be supplied by LanzaTech, the engineering work will be performed by Primetals, and E4Tech will develop the Life Cycle Assessment of the produced fuels. Several key players in the transport sector, Boeing, Virgin Atlantic, Mitsui, have expressed their strong interest and support for the project.";14560736,75;10192515,73;H2020-LCE-2014-2;IA;ARCELORMITTAL BELGIUM NV;BE;"ARCELORMITTAL MAIZIERES RESEARCH SA;LANZATECH UK LTD;PRIMETALS TECHNOLOGIES AUSTRIA GMBH;E4TECH (UK) LTD";"FR;UK;AT"; 195356;656908;NIMBLIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Laser Induced Synthesis of Biocompatible Multifunctional Inorganic Nanoparticles: A Novel Route to Produce Multifunctional Contrast Agents for Early Diagnosis of Breast Cancer;1/02/2016;31/01/2018;;The main goal of this IF research proposal is to produce novel nanoparticle-based multimodal contrast agents for their use in breast cancer diagnosis by combining Magnetic Resonance Imaging, Digital Mammography, X-ray Computed Tomography and Ultrasonography. In doing so, we will develop a new high-productivity strategy to synthesize multimodal hybrid nanoparticles, which consists in femtosecond-laser-induced-ablation of a metal plate immersed into a solvent containing chemicals, in combination with direct nanosecond-laser photolysis in solution of these chemicals. This research will be coupled to an in situ study of the high-productivity laser fabrication process and the analysis of the underlying mechanisms which allows the nucleation and growth of these hybrid nanoparticles. Moreover, we will analyze the structure, composition, physical and colloidal properties of the as-synthesized hybrid nanoparticles, as well as the in vitro performance of these nanoparticles as contrast agents in Magnetic Resonance Imaging, Ultrasonography and X-ray imaging techniques. We will also evaluate the citotoxicity of the as synthesized hybrid nanoparticles in normal cells and tumor breast cells lines. Finally, we will target these nanoparticles toward the human epidermal growth factor receptor 2 (HER2) which is overexpressed in breast cancers with a poor prognosis and higher disease recurrence, and we will evaluated in vitro the targeting ability of the obtained anti-HER2-nanoparticles conjugates for HER2\ breast cancer cells.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195588;658330;DEEPER;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deep Earth Elastic Properties and Effective Rheology;30/07/2015;29/07/2017;;"The interface between the Earths rocky mantle and molten outer core, located 2900 km below the surface, is marked by a patchwork of enigmatic structures. These structures, revealed by anomalous reductions in the speed of traveling seismic waves, are characterized by high density, partial melting, and low topographic heights (10-40 km above the core-mantle boundary). Due to the low seismic wave speeds, they are called UltraLow Velocity Zones (ULVZs). Since their rst discovery in the 90s, our understanding of the ULVZs has been based on seismic observations. The inuence of microscale distribution of melt and minerals on the seismic signature and the internal structure of the ULVZs remain a challenging question in geophysics. To address this question, this project will use a cross-scale approach to quantify the inuence of partial melting and solid composition on the elastic properties and rheology of the UL-VZs based on a microstructural model. Using the microscale constraints on the physical properties, the km-scale internal structure of the ULVZs will be simulated using a nite elements model.

The interdisciplinary approach of this project relies on using state-of-the-art high performance computational uid mechanics models to answer fundamental questions in Earth Sciences. The uniqueness of this approach arises from the special consideration of microstructures, a crucial, but difcult to quantify aspect in Earth sciences. The multidisciplinary aspect of this work will train the researcher in new modeling skills. Upon his return to India, where research in deep Earth is still in its infancy, the researcher will be able to establish his own research agenda leading the countrys effort in that area. Continued inter-national collaboration between the host institution and the researchers future group will be of enduring value to the EU.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE;UK;;; 195390;657096;MULTICELL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Division of labour and the origin of multicellularity;1/07/2015;30/06/2017;;"Understanding the evolution of multicellularity and cellular differentiation/ complexity is one of the greatest challenges in biology. Of particular interest is to determine the evolutionary processes (selective causes) and mechanisms underlying the evolutionary transition from single cells to multicellular organisms.

This project will use cyanobacteria as a model system to determine whether cellular differentiation is a cause or consequence of multicellularity. A novel theory will be tested, which predicts that the division of labour/ differentiation among cells drives the transition to a multicellular state. This will be contrasted with the classical view, where cellular specialization originates only at a much later state during the transition. The proposed project will adopt an interdisciplinary approach by combining experimental evolution (WP1) with phylogenomics (WP2). More specifically, populations of unicellular cyanobacteria will be subjected to long-term experimental evolution under two different regimes that favour either the specialization of cells into performing different physiologically incompatible processes, or the formation of non-differentiated aggregates (WP1). By linking the phenotype to the underlying genotype and to gene expression patterns, the critical steps for the transition to multicellularity will be established at the genome level. This evolutionary sequence will be directly compared to the one inferred from the cyanobacterial phylogeny (WP2). Here, whole genomes will be used to reconstruct the gain and loss events for the main multicellular traits, such as filament formation and cellular differentiation.

The findings will not only provide insight into the key events during the transition to multicellularity but will also be the first study that directly relates a transition that was achieved under artificial conditions in the laboratory to one that actually happened more than 3 billion years ago in this phylum.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL;DE;;; 195265;656422;MODFIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Model theory of finite and pseudofinite structures;1/06/2016;31/05/2018;;"The project is in model theory (mathematical logic), which concerns the expressibility in logical languages of properties of mathematical structures (e.g. graphs, groups, rings). Model theory aims to identify borders between `tame' and `wild' objects in mathematics, and to pin down abstract notions of independence and dimension and understand the geometry of `definable sets' in a structure, often with wide-ranging applications. This project focusses on classes of finite structures (e.g. the class of all finite fields), and on the `ultraproduct' construction which converts a class of finite structures to an infinite `pseudofinite' structure' which inherits properties of the class and is amenable to model-theoretic methods, with applications for the finite structures. Key objectives include:
(i) proving a trichotomy for pseudofinite geometries -- they should be `trivial', `group-like', or `field-like';
(ii) developing current concepts from abstract model theory for pseudofinite structures;
(iii) identifying first order properties of pseudofinite groups, and constraints on their possible quotients;
(iv) finding links between the model-theoretic `independence theorem', Gowers' notion of `quasi-random groups', and the Szemeredi regularity theorem in graph theory.
(v) model theory of finite ordered structures, and links to finite model theory.

To support his future academic research career, the Fellow, Garcia, will receive training through research in the model theory groups in Leeds and (through a secondment) Lyon. There will be knowledge transfer to Garcia of expertise in model-theoretic algebra of Leeds and Lyon, and Garcia will also build knowledge of finite model theory and its computer science applications. He will receive complementary training in many research skills (including outreach), and will transfer to Leeds expertise he has gained in the excellent model theory groups in Berkeley and Bogota, while deepening EU-Colombia mathematics links.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF LEEDS;UK;;; 195327;656794;DEFT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dark energy, non-linearites and effective theories;1/10/2015;30/09/2017;;The objective of this project is improving substantially our understanding of the acceleration of the Universe by developing novel effective techniques and semi-analytical methods for non-linear cosmological perturbation theory that will be applied to the data of upcoming high precision surveys. The accelerated expansion of the Universe was first detected in 1998 with Type Ia supernova data, and today there is ample evidence for it from various other observations such as the cosmic microwave background radiation (CMB) and the distribution of galaxies at large scales. We call dark energy the mysterious force that drives the acceleration of the Universe and understanding its origin is one of the major problems in cosmology of our time. The high precision of the near-future probes designed for elucidating the nature of dark energy needs to be matched with very accurate theoretical predictions, in particular concerning non-linear effects in cosmological perturbation theory. Developing efficient methods to compute these effects is a crucial requirement for the interpretation of the future dark energy data. I will apply the methods of effective field theories, that have been widely successful in many areas of physics, to develop new tools for describing dark matter and dark energy perturbations in the linear and non-linear regimes. I will combine these tools with state-of-the-art forecasting techniques to determine the prospects for the detection of dark energy parameters from future large scale structure data (specifically from Euclid) in combination with CMB data from Planck.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;;; 195361;656940;FUDACT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;FUll Duplex Active Cancellation for wireless communication and co-exisTence;1/07/2015;30/06/2018;;"'The development of fifth-generation (5G) wireless networks is expected to provide technologies to support 1000x increase in data rates. To support the vision of hundreds of billions of connected devices after year 2020, many of the new technologies need to be developed. 5G is expected to utilize many more spectral bands, several of them at millimeter-wave frequencies, and much denser deployment of wireless infrastructure. As a result, co-existence between systems will be the key problem to be addressed at the physical level. In 'Full Duplex Active Cancellation for wireless communication and co-exisTence' (FUDACT) we explore a set of new co-existence technologies culminating in a new radio transmission paradigm to improve spectrum efficiency. The FUDACT goal is to support two Europe 2020 flagship initiatives: Digital agenda for Europe by addressing some of the H2020 Future Internet challenges and Innovation Union by paving the way to innovation-friendly environment.
FUDACT aims at a fundamental understanding of limitations of active self-cancellation techniques under conditions of simultaneous transmission and reception in close or overlapping frequency bands. The project's primary goal is to deliver a solution for a shared antenna system capable of cancelling at least a 1W transmitter (densely deployed small cells in wireless infrastructure) in the receive band, a great research challenge advancing the state of the art by at least 2 orders of magnitude. To accomplish these ambitious goals we will be pursuing the following closely related objectives: (1) Determine the technology limits of active cancellation of self-interference in wireless transceivers (2) Demonstrate an architecture capable of cancelling a \23dBm transmitter and a 0dBm of narrowband blocker (3) Investigate mixer-first receiver architectures capable of tolerating higher blocker signal levels (4) Apply the techniques (1-3) in the design of a full duplex future-oriented wireless communication network.'";240172,2;240172,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERZITET U NOVOM SADU FAKULTET TEHNICKIH NAUKA;RS;;; 195352;656891;COUPCAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Coupling dimerisation and metathesis reactions to produce propene from ethanol using heterogeneous catalysts and microreactor systems;1/04/2015;31/03/2018;;"Biomass-derived molecules contain excess oxygen that must be removed to render as fuel or chemicals. Due to feedstock fluctuations, ethanol and ethene are becoming key components to overcome these challenges. Given the current bioethanol (fermentation) and ethene (crackers) excess, and the propene shortage in Europe, alternative routes are required. During the outgoing phase under the supervision of Prof. Iglesia at UC Berkeley (USA), the researcher Dr. Iker Agirrezabal-Telleria will address the fundamental mechanistic aspects of dimerisation and metathesis reactions from ethanol to propene operating at low-temperature and studying the individual parameters using multidisciplinary approaches. This will include spectroscopic (in-situ UV-VIS and FTIR ) and isotopic techniques to elucidate the contribution and role of active metals for dimerisation (Ni), isomerisation (H\) and metathesis (Re, Mo).
The optimised catalysts will be tested during the return phase under the supervision of Prof. Arias at the University of the Basque Country (Spain) using engineering approaches. Catalyst slurry and formulations will be prepared to test them on microreactor systems. The microreactors will be coated during a secondment period under the supervision of Prof. Kolb at Fraunhofer ICT-IMM (Germany). This phase aims to achieve process intensification and reduce heat-transfer issues occurring in packed-bed reactors. The comparison between fixed-bed and microreactors will enable to obtain interdisciplinary inputs to produce propene from ethanol.
This Fellowship aims to carry out cutting-edge scientific training and transferable skill training such as project management, relevant for the re-integration period and to become an independent research leader in Europe. Moreover, this projects aims to have a positive impact on European society and competitiveness. These actions will involve outreach activities, results dissemination and IPR management.";257191,2;257191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA;ES;;; 195534;658005;HYPERLIGHT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Combining hyperspectral luminescence imaging and mineralogical identification to date mixed-component samples from volcanic eruptions;1/09/2015;31/08/2017;;Volcanic hazards directly affect more than 10% of the worlds population, and have caused globally significant economic losses as recently as 2010. Accurate eruption frequencies are fundamental to risk management, and well-dated volcanic events can temporally link archaeological sites and palaeoclimatic records across hundreds of kilometres. Yet there are significant, known gaps in records of prehistoric volcanic cycles, and accurate luminescence ages for volcanic features would be of great value in future studies. However, volcanic products are mineralogically complex with some crystals producing inaccurate ages. We propose exploring and developing an innovative luminescence technique (spatially resolved luminescence, SRL) to date volcanic events. SRL uses an ultra-sensitive camera to image luminescence, so that signals can be easily compared with accompanying experimental data (e.g. mineral type or signal stability measurements). This project utilizes luminescence imaging at multiple wavelengths (hyperspectral) and mineralogical analyses to accurately date volcanic ejecta with mixed mineralogy. It builds on the expertise of the supervisor and experienced researcher (ER) in luminescence dating and imaging as well as statistical data analysis, and enhances the ERs skill set via training in volcanology, the development of analytical software, and the German language and culture. The ER will draw together an international network of leading scientists in industry (Freiberg Instruments) and academia (Universities of Freiburg, Bern, Oxford), allowing her to substantially enhance her leadership skills. As a subsidiary outcome, this project will also increase the European capacity in multiple connected fields, including composite strain analysis (aerospace) and detection of irradiated foods (food standards authorities).;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ALBERT-LUDWIGS-UNIVERSITAET FREIBURG;DE;;; 195304;656712;FE-RUS-Blast;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Finite Element Resonant Ultrasound Spectroscopy to Characterize Maturation of Cortical Bone Elastic Properties;1/04/2015;31/03/2017;;Osteoporosis has become a major public threat with high costs to the health system. As an important issue of research on osteoporosis, tissue elasticity, i.e. the whole set of the anisotropic stiffness constants on millimeter scale, that directly decides the bone resistance and fracture risk, is still poorly assessed by prevailing biomechanical methods. The state-of-art approach to determine bone elasticity is the ultrasonic pulse method by measuring acoustic velocities along various directions of a specimen with a major drawback of sample size limitation, typically larger than 5 mm. However, studies on bone metabolism greatly relies on small animals, e.g. rabbit, rat, and mouse, with cortical thicknesses close or smaller than 1 mm. Resonant ultrasound spectroscopy (RUS) has been well established to measure the anisotropic elasticity of small metallic samples. However, it was known to be not suited to high-damping materials like bone, due to complicated extraction of resonant frequencies from overlapping resonant peaks. We aim to develop a new RUS method for the accurate elasticity determination of small animal bones (femora and tibiae). New strategies of a non-linear optimization and Bayesian formulation of the inverse problem, recently proposed by the host lab, will be used to overcome the material limitation of bone attenuation. Moreover, the novel combination of the finite element (FE) method and RUS will be used to relax the regularly-shaped sample restriction for the practical application. The applicant will perform an extensive methodology development, including theoretical analysis, numerical simulation, signal processing, and inversion scheme. The new technology will be validated by measuring elastic maturation of cortical bone in rabbit model. The originality comes from the multidisciplinary combination of innovative technologies towards the bone elasticity determination in response to current technical deficiency of small animal bone quality evaluation.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;FR;;; 195359;656923;IRON_DEPOSITS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of volatiles in the formation of magmatic iron oxide deposits;1/06/2015;31/05/2017;;The formation of magmatic iron oxide deposit is closely related to the role of volatiles in magmas, especially in low-Ti magmatic systems (Kiruna-type). Volatiles have strong effect on phase equilibria, saturation of Fe-Ti oxides, and liquid immiscibility. They also control the magmatic-hydrothermal transition with implications for the remobilization of some strategic elements (P, Au, Cu, REE) by fluids. Volatiles are thus key components for the relation between Kiruna-type ores and Iron Oxides Copper Gold deposits. This project is an attempt to constrain experimentally the role of volatiles in magmas related to the formation of Kiruna-type iron deposits. We will study the development of liquid and fluid immiscibility, major and trace element partitioning between melts and fluids, and iron isotopes fractionation between minerals, silicate melts and fluids. The study will benefit from unique high pressure experimental and UV-femtosecond laser ablation-ICP-MS analytical facilities developed in Hannover. The objective is to constrain the conditions and the processes responsible for the concentration of iron in low-Ti volatile-rich magmatic systems and to identify the key-factors responsible for the enrichment of elements of economic interest.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER;DE;;; 195399;657141;F-Pole;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Significant or trivial: Fungi in Polar Ecosystems;1/09/2016;31/08/2018;;Fungi are major components of the Earth's biosphere, playing a pivotal role as decomposers and recyclers of nutrients across different environments. However, fungal diversity and function in marine environments has been poorly studied, leading to a biased picture of fungal distribution. Latest studies indicated a distinct marine fungal diversity, including chytrids which can affect algae and zooplankton communities because of their parasitic lifestyle or function as food source. The project intends to investigate the importance of marine fungi in polar-regions, environments that promote the occurrence of endemism and thus the detection of novel species. WP1 aims to study marine fungal diversity and distribution and to provide novel and unique information on the influence of environmental variables on the biodiversity of fungi in these important and changing environments. Two hypotheses will be tested in this work package: firstly, are the fungi identified representative of 'bona-fide' marine lineages and not land-derived origin? Secondly, do fungi represent a higher diversity in marine polar waters compared to temperate and tropical waters? WP2 aims to elucidate the genes transcribed by polar fungi in these atypical and cold environments. This work will allow me to understand the biological characteristics of these fungi that underpin their diversity and distribution profiles by using comparative meta-transcriptomic analysis of environments rich in polar chytrid lineages. Once both work packages are brought together they will help to fill the gap in our understanding of the marine environment, providing important information on ecology of marine communities. Polar environments are undergoing unprecedented changes, it is therefore crucial to understand important components of the microbial community, specifically fungi. The combination of diversity analysis and reconstruction of biological function will uniquely allow for such progress.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EXETER;UK;;; 195305;656737;IPSIBiM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Improved Patient Safety through Intensive Biosignal Monitoring;1/09/2015;31/08/2017;;"Hospitals can experience difficulty in detecting and responding to early signs of patient deterioration, leading to late intensive care referrals, excess mortality and morbidity, and increased costs. Joint replacement is a very common orthopaedic operation that raises additional clinical and safety questions. Caring for the orthopaedic patient requires a multidisciplinary team and treatment that includes: acute pain control, monitoring for post-operative complications venous thromboembolic prophylaxis, early ambulation, and rehabilitation. The major limitation of early warning systems is that they are based on manual checks performed by nursing staff, and that the observations, and therefore detection, only occur intermittently. Additionally, the false-alarm rate of such monitors is generally so high that the alarms are usually ignored. Despite recent developments in automated wireless systems that continuously record vital signals, a method for detecting patterns of deterioration that are specific to unique patient populations has not yet been studied. IPSIBiM targets the development of a system dedicated to post-operative orthopaedic patients monitoring based on wireless recording of real-time vital signs and analytical algorithms capable of providing guidance to clinicians of early signs of deterioration. The innovation in the project consists of four main elements: measurement of new vital signs in a wireless system; novel methods for deriving features and building models to measure recovery; automated pain measurement in post-operative patients; principled methods for novelty detection. The proposed concept will be implemented in a clinical feasibility study, where technical aims related to setting up the system, reliability and failures will be studied along with outcome measures for clinical evaluation. The research programme is highly multi-disciplinary as it will require expertise in sensor design, machine learning algorithms and medical applications.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195321;656774;Behaviour-Connect;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Behaviour-Connect: Testing hypotheses on the behavioural drivers of connectivity in the marine environment through novel Bayesian models;16/03/2016;15/03/2018;;"Connectivity is broadly defined as the exchange of individuals between populations. Assessment of connectivity is a key goal in ecology, evolution and conservation biology. At the ecological level, connectivity is key in the persistence and resilience of populations. At the evolutionary level, connectivity influences local adaptation.
In the marine environment, ecologists have primarily focused on biophysical models of larval exchange when investigating connectivity, because of the importance of such processes on exploited or commercial species. This has diverted attention from the potentially important role of behaviour as a driver of connectivity in the marine environment. Aspects of a species' behaviour, such as migratory fidelity, social structure and feeding specialisations, can play a strong role in shaping connectivity and gene flow that has been largely been ignored in connectivity studies to date.
I propose to address this knowledge gap by simultaneously harnessing leading empirical methods, micro-chemical markers and genomics, and integrating these into a novel Bayesian framework for testing hypothesis on the behavioural drivers of connectivity. I will apply this method to a globally distributed species, the southern right whale. This large, long-lived species is highly mobile, migrating between coastal winter calving grounds and high latitude offshore feeding grounds in summer. Southern right whales show maternally transmitted preferences for migratory destinations that could influence connectivity. The combination of well-described life-history traits and lack of barriers to dispersal makes the southern right whale an ideal species in which to investigate the importance of behaviour on connectivity. While providing insights into drivers of connectivity in the southern right whale, the project will generate broader hypotheses about drivers of connectivity and provide a model for combining different data types to rigorously test such hypotheses.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;;; 195452;657474;BIOMARK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biomarkers of disordered language in autism;14/03/2016;13/03/2018;;We know talk of the autisms. Evidence shows us that autism refers to a heterogeneous group of neurodevelopmental disorders. This heterogeneity has greatly hindered our understanding of autism. This proposal will attempt to disentangle this heterogeneity by focusing on one piece of the autism phenotype: disordered language. More specifically, we will focus on impairments involving phonology, the sounds of language. Infants acquire phonological skills in the first year of life. A disruption in the development of these skills can compromise or even preclude language acquisition. Behavioral studies have provided evidence for an autism subgroup defined by phonological deficits. This subgroup is hypothesized to overlap with specific language impairment (SLI), a developmental language disorder clinically marked by phonological deficits. Given that the presence of speech before age five is the strongest predictor of a better outcome for a child with autism, understanding language deficits that can be present at a very early age is critical. This study will be the first to utilize EEG to examine neural activity relevant to phonological processing in children with autism with and without SLI as well as children with SLI. Our primary goal is to identify biomarkers indexing impaired phonology that can inform earlier diagnoses and treatments for children with disordered language. In addition to this goal, undertaking this research at the BCBL and the University of Seville, which will provide access to both mono- and bilingual children, will enable us to address a critical gap in both autism and SLI research. Developing bilinguals are the rule in the world. Despite this, little is known about bilingualism in autism or SLI. Scientific evidence suggests that there is a bilingual advantage that sharpens the mind of bilingual speakers. Could there also be a bilingual advantage for children with disordered language? Or is bilingualism simply an extra burden for these children?;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE;ES;;; 195253;656347;GUTWORM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unravelling host intestine-parasite interactions that define immune responses to whipworms;1/10/2015;30/09/2017;;"Whipworms (Trichuris trichuira) are soil-transmitted helminths that infect about 700 million people in the tropics and sub-tropics and cause the human disease, trichuriasis. Whipworms live preferentially in the cecum of their hosts where they tunnel through epithelial cells and cause inflammation potentially resulting in colitis. Despite extensive research, the role of whipworm interactions with epithelial and immune cells in triggering parasite expulsion remains unclear, hindering the development of anti-parasite therapies. The ultimate goal of my research proposal is to investigate and understand this interaction in detail. To achieve this, I will use T. muris, a mouse
model of T. trichuira infection in humans. This research proposal has three key aims. First, to identify new parasite and host genes that could interplay and modulate immunological outcomes. Second, to characterize the role of host genes in whipworm infection and immunity. Here, novel and known candidate mutations conferring susceptibility to colitis identified through the Wellcome Trust Sanger Institute - Mouse Genetics Project will be targeted. Thus, I will challenge mutant mouse lines with T. muris and evaluate the influence of these mutations on anti-parasite immunity and expulsion. Finally, upon identification of key genes regulating the immune response to whipworms, I will explore the mechanism of action of selected genes and their effect on the parasite. For this, I will take advantage of the vast range of omic technologies and facilities available at the WTSI. This project will generate novel fundamental data on host-whipworms interactions and also support future efforts to control these parasites by the identification of potential new therapeutic targets. Moreover, resulting knowledge of the parasiteimmunological interplay could be exploited to understand other intestinal inflammatory diseases such as ulcerative colitis that have many similarities with trichuriasis.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Genome Research Limited;UK;;; 195344;656869;COSMIC SHEAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cosmic Shear Analysis of the Kilo Degree Survey: Cosmological Constraints;20/01/2016;19/01/2018;;"Weak gravitational lensing is one of the most promising techniques for probing and mapping the dark matter distribution within our Universe. Using lensing, we can simultaneously measure the total mass, the number of neutrino species and the global acceleration of the cosmic expansion, offering a direct handle on the mysterious dark energy. This Marie Sklodowska-Curie action will carry out one of the most competitive cosmological analyses to date by measuring cosmic shear from the weak lensing data acquired by the state-of-the-art European Southern Observatory Kilo Degree Survey (KiDS). We will place tight constraints on the theoretical parameters that describe the dark Universe. In addition, this analysis has the potential to reveal which galactic baryonic processes, between active galactic nuclei, sustained stellar winds or supernovae bursts, effectively feedback on the total matter density field.

This scientific programme is central to an international collaboration that brings together the Fellow's expertise in theoretical and numerical modelling with world class experts on image processing, galaxy shape and distance estimation, weak lensing calibration and interpretation. The Fellow will analyze the KiDS data to its full potential by employing new methodology and including key ingredients to the analysis, for which his numerical simulations and mock galaxy catalogues are critical. Combined with innovative approaches in the treatment of the astrophysical and systematic uncertainties in weak lensing analyses, the project will guarantee a high level of precision and robustness in the resulting cosmological parameter constraints.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195290;656572;MobileLinks;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mobile links in fragmented landscapes: implications for biodiversity conservation;1/12/2015;30/11/2017;;"Dispersal through anthropogenic habitats (i.e. the matrix) is necessary for the inter-population connectivity and the colonization of vacant habitats after disturbance, thereby for the long-term persistence of species in fragmented regions. A critical question for conservation is whether differences among species in dispersal translate into biodiversity loss through biotic homogenization. The ability of fleshy-fruited plants for dispersal though the matrix relies on their capacity to interact with those frugivore species that move across its habitats providing key seed dispersal services. Organisms that connect habitats in the landscape are termed mobile links and are considered essential for ecosystem resilience. However, there is a lack of knowledge about the mobile-link function in seed dispersal networks and its role on biotic homogenization. This proposal aims at filling this gap by providing a large-scale and integrative assessment of seed dispersal by avian frugivores through fragmented landscapes of Europe. Specifically, it aims at assessing empirically (1) whether interaction constraints between plant species and those frugivore species that act as mobile links are a driver of long-term biotic homogenization in fragmented regions; and (2) whether certain phenotypic plant traits that favour interactions with mobile-link frugivores could be used to predict good dispersers and poor dispersers of target plant communities. This proposal includes several study sites scattered through Europe, assuring generalization of the results. It combines field sampling and ground-breaking DNA-barcoding techniques for resolving seed dispersal networks, which will provide unprecedented information about the functional value of specific frugivore species in fragmented landscapes. Resulting knowledge can be incorporated into management and policy-making decisions for preserving woodland biodiversity in fragmented regions.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195573;658248;SHDS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Seismic-resistant Highly Deformable Structures;1/05/2015;30/04/2017;;"The recent earthquakes that have struck Europe the last decade, LAquila (2009) and Lorca (2011) have shown that even for a moderate seismic hazard level the seismic action can cause huge personal and economic losses. Therefore there is a need for new structural designs based on the performance of the structures during earthquakes rather than their strength. This project will focus on the development and verification of a novel seismic-resistant highly deformable reinforced concrete structure. This innovative design takes advantage of the superior deformability of reinforced High Deformability Concrete (HDC) elements to develop a structure with controlled performance, in which the structural damage is concentrated in especially designed elements.
The new structural system combines ductile shear walls with flexible coupling beams designed with reinforced HDC. HDC is currently being developed by the host Institution as part of Anagennisi, a FP7 EU funded project, and utilises recycled rubber particles as replacement of both fines and coarse aggregates. A preliminary experimental investigation is being undertaken to characterise the mechanical properties of HDC, and complimentary testing is planned to be carried out as part of this fellowship. This initial multi-scale testing phase will be followed by the development of a material model and its implementation in a finite element software for the analysis and assessment of representative prototypes of seismic resistant highly deformable structures. The new structure will be more sustainable as it will be easily repairable after an earthquake and will have a better seismic performance avoiding non-structural damages. This project will contribute to the development of new technology in Europe, and will provide an important stepping stone for the fellows career.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195341;656847;RIDEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rwenzori Ice Dynamics and Environmental Changes;7/09/2015;6/09/2017;;"At the border between Uganda and the D.R. of Congo, the Rwenzoris form a remote and high-altitude mountain range stretching through the East African Rift System. With heights of 4-5 km, they include Africa's third highest peak (Mt. Stanley, 5109 m) as well as some of the last African glaciers. The combined area of the Rwenzori glaciers declined by more than 75% during the 20th century, and halved between 1987 and 2006. This extreme mass loss may have strong implications for the local hydrology, ecosystems and communities, and recent estimates suggest that the glaciers will disappear in the next decade(s). This trend correlates well with similarly dramatic glacier retreats on Mt Kilimandjaro (Tanzania) and Mt Kenya (Kenya) during the same period, and is attributed to increased air temperature or reduced humidity/cloud cover. Despite recent work on the evolution of glacier extent in the last decades, the measured glacier retreat, as well as the interpretation of the driving climatic factors responsible since the 1980s, remain controversial and are limited to available data.
In order to better understand the dynamics of this recession, we will survey the current state of the two largest Rwenzori glaciers, Stanley and Speke glaciers, using a panel of remote sensing, geophysical and geochemical methods. These include, first, surveying of glacier extents over the last decades using satellite imagery, mapping of the current glacier extent and main features using differential GPS, and assessing the glacier thicknesses using ice-penetrating radar. These three steps will allow for further ice flow modeling. Second, the use of weather station data in the glacier vicinity as well as ice/water sampling for geochemical analysis will allow investigating the glacier sensitivity to the changing climate and its (palaeo-)environmental potential. These results will be compiled with a view to provide a first estimate of modern, past and future ice budgets in the area of interest.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;MUSEE ROYAL DE L'AFRIQUE CENTRALE;BE;;; 195437;657359;PVFIFTY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;TOWARDS A 50% EFFICIENT CONCENTRATOR SOLAR CELL AND A 40% EFFICIENT SPACE SOLAR CELL;1/05/2015;30/04/2017;;"Concentrator photovoltaic solar collectors have the potential to generate electricity at costs as low as 6/kWh, a price where they compete favourably with wholesale electricity prices. To achieve this, a solar cell with an efficiency in excess of 50% is required and will require considerable development over the present state of the art. In particular, a new semiconductor absorber layer with a 1eV band-gap will be required in addition to solar concentrations in excess of 1000X. The proposed research addresses both of these areas.

Preliminary work has identified the use of bismide semiconductors to achieve the required 1eV semiconductor junction. A 1eV GaAsBi0.062 layer can be grown that has only 0.6% mismatch to GaAs, as compared to conventional In0.3GaAs that introduces >2% mismatch. We will develop high-performance photovoltaic devices based on this material. We will characterise the optical and electronic structure of these new materials using spectroscopic ellipsometry and photo/electroreflectance. The nature and concentration of defects will be determined using time-resolved optical spectroscopy and correlated with solar cell performance data by extending existing computer models.

To achieve high efficiencies at high concentrations, it is necessary to reduce the resistive loss. Here, we propose to exploit lateral emission in tensile quantum well (QW) layers to provide a parallel radiative transport pathway that delivers photogenerated charges to the electrical contacts. A series of InGaP/InGaAsP QW test structures in compressive, tensile and unstrained configurations will be grown to control the directionality of emission, which will be confirmed using spectroscopic measurements. Concentrator solar cell device structures will be processed and the effective sheet resistivity evaluated using electroluminescent imaging. Front grid structures we be redesigned to account for radiative transport.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195250;656333;PEACEFUL MIND;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Effectiveness evaluation of traditional and third wave Emotion Regulation strategies in clinical and non-clinical youth population;1/04/2016;31/03/2018;;Mental-Health problems in youth such as disruptive behavioural disorders, substances abuse, aggressive behaviors, depression, anxiety, etc. is an expanding and global concern. Numerous Mental-Health problems in youth are significantly related with poor capacity of Emotion Regulation (ER). Adaptive ER strategies influence the intensity, duration, and expression of emotions, modifying emotional reactions in a socially tolerable and sufficiently flexible way. Thus, learning adaptive ER strategies has strong potential in promoting physical and psychological well-being in youth. However, the promise of an easy access and implementation of ER programs remains disappointedly unrealised for the following reasons. (1) Learning of ER competencies is almost invisible in European school curricula. (2) There is a lack of studies in youth that compare ER strategies to provide sufficient evidence-based criteria and guidelines. (3) The needs of the digital natives generation have not been taken into consideration in ER programs, often lacking the engaging and motivational aspects and a high quality assessment. (4) There is an issue of adaptability of ER interventions to the school context. Thus, the main objective of PEACEFUL MIND is to develop an attractive program, using Information and Communication Technologies, as well as ecological and objective measures, to teach youths adaptive ER strategies. By doing so, we will directly influence social, emotional, and cognitive development of youths that will have an impact during their entire lives. Finally, the multidisciplinary training objective will provide an extensive clinical training in third wave therapies, training in research methodology, gaining experience in teaching, tutoring, and additional research competencies, which will open up the opportunity to become an expert in both the academic and private sectors, and will greatly contribute to my objective of becoming a scientific leader in third wave therapies and e-health.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195384;657050;RES.CO.PART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Research Consultation and Participation:developing a tool for managing cultural heritage and landscape;1/09/2015;31/08/2017;;"This project aims to devise and implement a new tool for the sustainable management of cultural heritage. The RES.CO.PART tool will promote the efficient involvement of communities as stakeholders in decision-making processes for the management of cultural heritage in landscape. It will combine interdisciplinary methods of spatial analysis (especially Geographic Information System (GIS) based Historic Landscape Characterisation (HLC)) in a new way with research practices from cultural anthropology. The tool will help bridge the gap between theoretical appreciations of cultural heritage and the management practices that are actually applied on site. The tool will be developed through practical case-studies in two contrasting communities, Naxos in the Aegean Sea (Greece) and part of the East Devon Area of Outstanding Natural Beauty (AONB) (UK).

To implement this project, Dr Stelios Lekakis will move from Greece to Newcastle University in the UK, undertaking systematic training in GIS-related methodologies and especially the HLC tool, along with related skills in the visualisation of results for the public. The project results will be disseminated through a specifically designed open platform. To create this, he will also be trained in the process of building a digital, open-access tool for the collection and communication of relevant data by interested stakeholders.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 195311;656731;ECAMMETT;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Early Cenozoic Asian Monsoons: Mechanisms and Evolution Through Time;1/09/2015;31/08/2017;;"The Asian Monsoon is primarily driven by continent-ocean thermal contrasts, and frequent hydro-meteorological extreme events emphasize that it is affected by recent global climate change in response to increasing atmospheric level of carbon dioxide (pCO2). The medium and longer-timescale effects of circulation changes in the monsoon system control precipitation in continental Asia and, in the past, shaped Eurasian paleoenvironments and biotic evolution. The Asian monsoons have long been thought to have originated ~23 Million years ago, driven by regional uplift. However, recent studies have shown that the monsoons are millions of years more ancient than previously thought and were regionally similar to today during the high pCO2 Eocene Greenhouse episode. These studies open a vast array of new questions: (1) How did these early monsoons evolve through the Eocene? (2) How did they react to the numerous, short-term hyperthermal and hypothermal pCO2 events that ruled this period? This research project proposes to address these issues by focusing on three key sedimentary records in the Eocene monsoonal realm: in China, Myanmar, and Turkey. After refining the local stratigraphy through U/Pb geochronology of volcanic deposits, the three records will be investigated with respect to different geochemical and mineralogical paleoclimatic proxies. Elemental geochemistry and clay mineralogy will help to understand the evolution of seasonality and precipitation; stable and clumped isotope analyses on pedogenic carbonates and soil organic matter will document past rainfall amount, temperature and pCO2 variations; U/Pb dating on aeolian dust deposits will allow the reconstruction of past wind patterns. The resulting findings will document the short- and long-term variations of the monsoons during the Eocene, and in light of modern global climate change, will furnish the basis for a substantial advance in our understanding of monsoonal forcing factors in a warmer, high-pCO2 world.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET POTSDAM;DE;;; 195306;656655;BATTLE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The molecular basis of NleB-mediated bacterial virulence;4/01/2016;3/01/2018;;Bacterial pathogens have evolved distinct ways of colonizing host cells and promote infection. Many human intestinal bacterial pathogens such as Salmonella, Shigella and enteropathogenic/ enterohemorrhagic Escherichia coli utilize type III secretion systems to deliver virulence effector proteins into the host to promote colonization and interfere with antimicrobial host response. Among the type III effectors, the NleB protein has been shown to be essential for virulence of enteric pathogens. NleB is a glycosyltransferase that has been shown to interact with host cell death-domain-containing proteins, GlcNAcylate a specific arginine on these and thereby inhibiting death receptor signalling and preventing host cell apoptosis. This proposal will 1) investigate how NleB specifically recognises the host death domains, 2) uncover the molecular mechanisms of arginine GlcNAcylation, 3) explain how death domain GlcNAcylation prevents the death domain from binding to its receptor, and 4) exploit this molecular information to generate bisubstrate inhibitors to interfere with this process.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Dundee;UK;;; 195238;656264;LAGRANGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;LAte Glacial RANGe Expansion;1/04/2016;31/03/2018;;"From around 25 to 20 thousand years ago, most of northern Europe was covered by ice and humans retreated into refuges in the warmer southern territories. The archaeological record of the Western European Late Pleistocene clearly indicates a refuge encompassing the areas of Cantabria, in northern Spain, and Aquitaine, in southern France. Both archaeological and genetics evidence agrees that it was from this Franco-Cantabrian refuge that Western Europe was repopulated in several phases starting at around nineteen thousand years ago. As pioneer groups expanded their ranges into previously uninhabited northern territories, Late Glacial hunter-gatherers had a unique opportunity to engineer their evolving ecosystem or niche. According to the Niche Construction paradigm such practices deeply change the selective pressures of that niche on its populations, both human and non-human, thus affecting not only cultural transmission, but also biological/genetical transmission: a triple inheritance model.
The LaGRangE project proposes to study the Late Glacial hunter-gatherer range expansions, and the role of Niche Construction in these. This will be achieved by an interdisciplinary approach to the problem applying established Computer Science methods to archaeological data. Firstly Niche Construction triple-inheritance models will be modelled to understand how niche construction affects the dispersal dynamics of a given population. This new understanding will then be used to model the Late Glacial dispersal of humans out of the Franco-Cantabrian refuge, on a biogeographically realistic domain. This approach will help identify routes, preferred habitats and other dispersal choices taken by the expanding groups.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO PRIVADA INSTITUT CATALA DE PALEOECOLOGIA HUMANA I EVOLUCIO SOCIAL;ES;;; 195518;657867;2G BIOPIC;SIGNED;"H2020-EU.3.3.3.1.;H2020-EU.3.;H2020-EU.3.3.;H2020-EU.3.3.3.";LCE-12-2014;H2020;Second Generation BIoethanol sustainable production based on Organosolv Process at atmospherIc Conditions;1/05/2015;1/05/2018;;"The purpose of the 2G BIOPIC project is to demonstrate the performance, the reliability and the sustainability, of the whole value chain of production of bioethanol from agricultural residues and wood. 2G BIOPIC aims to design, construct and optimize a second generation (2G) demonstration plant with a capacity of 1 T of biomass/h. This 2G plant is based on the scale-up and optimization of bioethanol production from an already validated pilot plan scale (50Kg/h) achieved in a previous project (FP7 BIOCORE).
The innovative patented concept proposed by 2G BIOPIC consists of cleanly deconstruct lignocellulosic biomass before converting its components into high value products. Thanks to optimized process conditions, the polysaccharides fractions are free from degradation products and inhibitors, allowing a very high ethanol yield using a low amount of enzymes and yeasts. By combining this technology with advanced strains for enzymes and a production of yeast able to ferment more than 90% of C5 and C6 sugars of the biomass, the 2G BIOPIC technology will result in i) higher bioethanol yield per ton of biomass process (20% more compared to competing technologies), ii) multi-feedstocks interoperability, iii) higher profitability of the process through the production of a high value bio-based co-product: the BioligninTM .
All critical steps of the value chain will be integrated to optimize bioethanol production (yield and production costs) and the high commercial value of the co-product (BioligninTM) will be demonstrated in the business case. Risk management will cover the all project, identifying potential risk and implementing mitigation plans. The data and experience generated during the project will demonstrate the technical viability, environmental, social and economical sustainability of the 2G BIOPIC technology and produce the knowledge necessary for the future scale-up to a flagship plant.";35195225;19999544;H2020-LCE-2014-2;IA;COMPAGNIE INDUSTRIELLE DE LA MATIERE VEGETAL CIM V;FR;"BIO BASE EUROPE PILOT PLANT VZW;DYADIC NEDERLAND BV;taurus energy ab;ROLKEM;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE INSAT";"BE;NL;SE;FR"; 195375;657007;FRAMAB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Flood Risk Assessment and mitigation for Masonry Arch Bridges;1/10/2015;30/09/2017;;The FRAMAB project aims to develop novel modelling strategies for masonry arch bridges and a comprehensive framework for the flood risk evaluation for these heritage structures. Although masonry arch bridges are very vulnerable to flood effects, no accurate procedures have been proposed thus far to systematically assess the risk of their damage and failure due to flood hazard. The procedures to be implemented into a flood risk assessment framework should combine a realistic description of the hazard (probability of exceeding a given flood discharge) with an accurate assessment of the structural vulnerability (probability of exceeding a given damage level in the bridge components for a flood with a given intensity). The development of such a risk assessment framework, which is the main objective of this research, requires a strong multi-disciplinary approach and will entail i) the advancement of computational tools for the response prediction of masonry bridges subjected to flood-induced actions and ii) the accurate propagation of uncertainties inherent in the loading, the problem parameters and the simulation models. In particular with reference to the first point, innovative nonlinear analysis capabilities for masonry arch bridges under flood effects will be implemented within the computational framework already available at Imperial College. This will allow an accurate yet computationally efficient prediction of the most critical flood-induced actions (e.g. flow pressure, floating debris impact, scouring). With reference to the second point, advanced probabilistic techniques will be developed to enable the prediction of the effects of the relevant sources of uncertainty on the bridge vulnerability. The project outcomes will contribute to the preservation of cultural heritage and to the development of innovative solutions for reducing the flood risk of infrastructural systems by promoting the unbiased allocation of the economic resources for flood risk mitigation.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195329;656811;USES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding Social-Ecological Systems: Coupling population and satellite remotely sensed environmental data to improve the evidence base for sustainable development;1/11/2015;31/10/2017;;"In developing countries the majority of rural communities rely on natural resources and environmental products for food, fuel, building materials and medicines. Rapidly changing socioeconomic conditions can have important consequences for environmental resources and ecosystem services. Consequently, the pressure that natural resources experience from population growth is a significant barrier to sustainable human development. This research project will broaden the approach to sustainable development research by studying population-environment relationships using data with unrivalled spatial and temporal resolutions. The objectives of the research are to identify: (1) How satellite data can be used to estimate aspects of environmental resources and ecosystem services important for livelihoods; (2) the relationships between household poverty and remotely sensed environmental conditions? And are these relationships consistent at different time periods? and; (3) how changes in poverty relate to changes in environmental conditions and vice versa? To study these relationships household panel survey data and remotely sensed environmental data will be coupled using GIS and non-parametric Classification and Regression Trees (CART) and random forests models which can handle and represent meaningfully the complex, nonlinear relationships between poverty and environment. The project will contribute to the Horizon 2020 aim of furthering sustainability science by exploring how changes in society and the environment are linked and contribute to society beginning to think about interventions to managing environmental resources which could contribute to development and to understand the changes likely in environmental resources when development occurs. It will contribute to the Work Programme as the fellow will gain new skills and training in geospatial and computational ecology and become an EU leading specialist in a research field with a lot of growth potential.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 195337;656830;DRC-ECSA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hierarchical surface patterns from dissolution-reaction-crystallisation mediated evaporation controlled self-assembly (DRC-ECA) and its antimicrobial coating application;4/09/2015;3/09/2017;;"A preliminary study by the applicant (Dr. Hua Wu (HW)) has proposed a novel dissolution-reaction-crystallisation mediated evaporation controlled self-assembly (DRC-ECSA) mechanism, from surprising and unprecedented observations of complex residual surface patterns with hierarchical architecture self-assembled upon evaporative drying of a ZnO nanofluid droplet. This mechanism is very di?erent from that previously established for the co?ee ring e?ect and other ECSA processes, and the morphological and nanostructural details of the obtained surface patterns also depend intricately on thus are tuneable by a range of physical parameters. Much of the complexity due to these corroborating factors remains to be fully explored. The aim of the project is threefold: 1) to fully understand the DRC-ECSA mechanism by comprehensively investigating the effects of physical parameters such as the solvent mixtures, evaporation rate, ZnO nanofluid concentration, shape and size of ZnO particles, addition of surfactants and polymers, substrate chemistry, droplet volume, temperature and humidity; 2) to apply and extend the DRC-ECSA mechanism (e.g. in a confined geometry and using binary particle mixtures) to obtain sophisticated surface patterns with tailored morphologies and hierarchical structures; 3) to evaluate the efficacy of the surface patterns for potential applications in antimicrobial coatings. By leading and engaging in the proposed project, Dr. HW will acquire new skills and knowledge in a range of interdisciplinary and multidisciplinary scientific and technical areas, including non-equilibrium ECSA, nucleation and crystal growth, morphological and structural characterization, nanoparticle synthesis, and microbiology of nanostructured surfaces. A broad range of transferrable skills acquired through the enriching experience of this interdisciplinary project will be very beneficial to Dr. HWs longer term career plans to become an independent research leader.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195346;656873;VCSD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Visualising Chromatin Structure and Dynamics at the Nanometre Scale with Super-Resolution Fluorescence Microscopy;1/04/2016;31/03/2018;;"Recently, it has become evident that the spatial organization of chromatin within nuclei is a key factor that can regulate gene silencing and expression. This organization is particularly important in pluripotent stem cells that differentiate into all cell types of the body through chromatin remodelling coupled to altered gene expression. Therapeutic use of these cells demands precise control over chromatin structure to direct differentiation. However, chromatin structure remains poorly resolved due to the nanometre length scales involved and limitations of low spatial resolution, poor signal-to-noise and ensemble averaging in existing methods. VCSD utilizes cutting-edge super-resolution fluorescence microscopy (SRFM) that overcomes these limitations. VCSD will, for the first time: 1) visualize global, 3D chromatin nanoscale structure in individual cells during differentiation; and 2) correlate the dynamics of local chromatin restructuring with the silencing of a central pluripotency gene. The proposed Marie Curie Fellow, Jason Otterstrom, PhD Harvard Biophysics, has extensive experience in fluorescence microscopy applied to biological systems. The host lab supervisor, Dr. Lakadamyali, is an expert in SRFM, at the Institute for Photonic Sciences, Barcelona. A secondment is planned in the lab of Dr. Cosma, an expert in the genetic mechanisms controlling pluripotency, at the Barcelona Center for Genomic Regulation. The combined expertise of the fellow and host labs is uniquely suited to establish VCSD as a novel framework for characterizing chromatin structure. The methodology developed is anticipated to be adopted by researchers in stem cell and chromatin biology fields, thereby reinforcing Europes global reputation in scientific innovation. The Fellowship will enable Jason to pursue applications of the chromatin structural metrics determined here as an independent biophysical researcher, with the long-term goal of commercializing a stem cell classification system.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 195289;656566;LQTS-HORSES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Platform for diagnosing long QT syndrome in horses - Step II: Identification of long QT syndrome;1/10/2015;30/09/2017;;"The Equine Cardiac Group at the University of Copenhagen has established a platform for diagnosing long QT syndrome (LQTS) in horses. In men, this condition is a cause of severe ventricular arrhythmias leading to death in some cases. The pathophysiological mechanism behind this disturbance of the cardiac rhythm is a delayed repolarisation often associated with reduced function of voltage gated potassium (K-) channels. LQTS is one of the cardiac causes of sudden death in athletes. Sudden deaths occurring during public events have a highly negative impact on the public perception about high performance sports, both in men and in horses, and raise concerns about animal welfare especially in the racing industry.
With the new tools developed by the Equine Cardiac Group the presence of LQTS will be investigated in horses by screening ECGs from a large pool of horses with different genetic backgrounds. Genetic sequencing will be performed on blood samples from this population and from horses with sudden death to describe genetic polymorphisms or mutations in the K-channels. The identified equine sequences will be compared to those described for men and the function of the identified mutations will be characterized electrophysiologically using voltage-clamp techniques, generating then new insights into the pathophysiology of LQTS in horses.
The benefit of the proposed project will be triple: 1) It will allow for identification of LQTS in horses and will aim at developing a reliable diagnostic test to screen horses for LQTS; 2) It will enable us to exclude them form racing and to reduce sudden deaths during sport events and therefore it will increase safety and animal welfare in racing industry, an important economic factor for many European areas; 3) Similitudes between men and horses in regard to the pathophysiology of LQTS might establish horses as a valuable model for investigating disturbances of repolarisation, especially those occurring in highly trained athletes.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195558;658155;CHLOROIRIDOIDS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Elusive enzymes with biocatalytic potential: chlorinases in the plant kingdom;1/12/2015;30/11/2017;;A plethora of halogenated natural products documents the existence of halogenases in plants but the responsible enzymes remain elusive. Chlorinated iridoid glycosides, for instance, occur in Phlomis, a genus in the mint family. Based on knowledge of iridoid biosynthesis and a mechanistic hypothesis for the chlorination reaction, we aim to discover the underlying enzymes. We will sequence transcriptomes of Phlomis tissues in different metabolic states, identify homologs of enzymes involved in iridoid biosynthesis, and search for candidate genes showing similar expression patterns. Among these candidates, the chlorinase will be identified by assaying the reactivity of heterologously expressed protein in vitro. Biochemical and structural characterization of the chlorinase will clarify whether chlorine incorporation proceeds via a rare epoxide opening mechanism. The level of chloroiridoid production will be assessed in plants after silencing the chlorinase, in order to confirm the metabolic role of the newly discovered enzyme. Furthermore, transient expression in plants providing structurally diverse precursors will reveal whether chlorinated natural products can be made that are new to nature. The discovery of a chlorinase in higher plants will fill an important gap in our understanding of plant secondary metabolism. Given the potential of chlorine for enhancing protein-ligand interactions, such enzymes would become useful tools for biocatalysis and the engineered biosynthesis of natural products with fine-tuned medicinal properties.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JOHN INNES CENTRE;UK;;; 195326;656787;Ethics and Ageing;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ethics and Ageing;1/10/2015;30/09/2017;;"Population aging will raise formidable ethical challenges for the European Union in the coming decades. Declining fertility rates and increased longevity are gradually increasing the dependency ratio the ratio of persons aged over 65, to persons of working age. In 2010, the EU-wide dependency ratio stood at 26%; by 2050, it will rise to 50% (Eurostat projections). As the balance in numbers shifts from citizens who work to those who are retired, the question of how to sustain the key programmes of the welfare state becomes ever more pressing. How can EU public policymakers best maintain their commitment to social solidarity under conditions of population ageing?
This research project proposes a comprehensive analysis of the ethical challenge posed by population aging. It is based on the following guiding observation: while European Union policy-makers (especially in the European Commission) are conscious of the fact that the EU needs an overall strategic approach to this challenge, they do not have at their disposal scholarship that provides an ethical analysis of this challenge at the appropriate level of generality.
The project will be based in the Department of Philosophy of Law at Universitat Pompeu Fabra (UPF). It will be supervised by Professor Andrew Williams, one of the worlds leading political philosophers, under the auspices of the UPF research group, the Philosophy of Law. Additionally, the project will be developed in dialogue with one of the worlds leading social scientists on the welfare state and population aging, Professor Gsta Esping-Andersen, who runs the DEMOSOC research group at UPF. The project will thus have an interdisciplinary character, moving back and forth between ethics and social science, and more specifically, between these two research groups at UPF, with the aim of producing comprehensive and grounded guidance on a key challenge facing the European Union.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitat Pompeu Fabra;ES;;; 195422;657264;BIOeSPUN scaffolds;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bioactive glass in electrospun matrices: functionalised smart scaffolds for interface tissue engineering applications;1/06/2015;31/05/2017;;The project aims to fabricate and characterise novel type of multilayered scaffolds suitable for interface tissue engineering applications, in particular for osteochondral segment regeneration. Osteochondral defects imply injury in cartilage, bone and bone-cartilage interface tissues, characteristic of all the joints of human body, its causes could be both traumatic and due to aging-related pathologies. The project will be focused on the integration of several scaffold fabrication techniques for the development of novel electrospun multilayered scaffolds. In particular, considering the well-known effects of bioactive glass on osteogenesis, angiogenesis and its antibacterial activity, electrospun bioactive glass mats will be fabricated. Moreover, bioactive glass particles will be dispersed in a polymeric solution before the electrospinning for the fabrication of bioactive glass-doped mats. These two kind of scaffold will be used for the fabrication of the multilayered structures. Innovative solutions will be adopted for the obtainment of the stratified samples, integrating different technologies as the electrospinning, freeze-drying and foam replica method. The training of the researcher in the host Institution will be focus on the development of skills related to cell culture management and in particular on cell culture for tissue engineering. The training will start with cell viability tests and cell seeding on several kind of scaffolds. Several cell lines will be used and it will be also investigated stem cells differentiation. The use of co-culture systems and dynamic cell culture will also be evaluated and eventually applied to the multilayered scaffolds. An innovative approach will be used in the investigation of scaffold mechanical properties, in fact mechanical tests will be performed on the multilayered samples and on each single layer to evaluate the deposition of ECM on the seeded scaffolds and how it affects scaffold mechanical properties.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Friedrich-Alexander University (FAU) Erlangen-Nrnberg;DE;;; 195235;656249;CADORS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Computer-Aided Design Of Revolutionary Superalloys;1/09/2015;31/08/2016;;"Metallic alloys are used in many industrial applications, needing the constant development of new materials with tailored properties. However, the relations between composition, processing and properties are so complex that alloy development cannot be made anymore by a traditional trial-and-test procedure, and there is a growing need for models able to predict the behaviour of alloys as a function of composition, and for computer-aided optimisation tools for alloy design. The aim of the project is to develop new predictive models, and to include them in computing tools for the design of new nickel-base superalloys for aeronautical, energy and chemical engineering applications, through an automatic optimisation of composition by multi-objective genetic algorithms. Alloy design tools already exist and rely on a number of predictive models; we intend to extend the range of predictive tools by developing, in the case of multi-phase Ni alloys, on the one hand a model for dynamic recrystallisation (DRX) and on the other hand a model for the resistance to hydrogen embrittlement (RHE). First, computational thermodynamics will allow calculating the compositional dependence of microstructure, through the prediction of the nature and fractions of secondary phases, as well as of the driving force for nucleation, which will be used to evaluate the precipitate size and density. Then, the new models will describe the roles of precipitates on DRX (by acting as nucleation sites for the formation of new grains, or at the opposite by acting as pinning centres for grain boundaries, limiting their mobility and hence retarding or inhibiting DRX), and on RHE (by influencing, among others, the distribution of hydrogen between the matrix, the precipitates, the grain boundaries and the precipitate-matrix interfaces). Once developed and assessed, these models will be integrated as new criteria in an automatic optimisation tool for superalloy design, using multi-objective genetic algorithms.";97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195297;656676;FEAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of Fluid pressure in EArthquake Triggering;1/12/2015;30/11/2017;;"Fluid overpressure has been proposed as one of the primary mechanisms that facilitate earthquake slip along tectonic faults. However, elastic dislocation theory combined with friction laws suggests that fluid overpressure may inhibit the dynamic instabilities that result in earthquakes. This controversy poses a serious problem in our understanding of earthquake physics, with severe implications for both natural and human-induced seismic hazard. Nevertheless, currently, there are only a few systematic studies of the role of fluid pressure under controlled, laboratory conditions for which the evolution of friction parameters and slip stability can be deduced. Here I propose a comprehensive experimental study of The role of Fluid pressure in EArthquake Triggering (FEAT). The proposed work will document the evolution of fault friction parameters as a function of fluid overpressure using a world-class rock deformation apparatus. The laboratory experiments will build on the characterization of fault zone structure, fluid flow, and deformation processes, which I intend to reconstruct from careful field evaluations of ancient faults that represent exhumed analogues of seismically active structures. An important part of my work will be the interaction with the energy industry to investigate the role of fluids in induced seismicity.
The experimental work will strengthen my expertise in frictional and fluid flow characterisation of fault rocks. Additionally, I will develop new skills in electronic and mechanical engineering aspects of experiments. Field and microstructural work will widen my background in the field of structural geology, microstructural analysis and model construction using energy-industry software. These training-through-research activities will allow for the creation of unprecedented insight into the role of fluid pressure in earthquake triggering while broadening my competences via interdisciplinary studies and inter-sectorial experience.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA;IT;;; 195314;656738;INHABIT Cities;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating Natural, Historical, And Institutional Transformations - Cities;14/09/2015;13/09/2017;;"The overall aim of INHAbIT is to improve understandings of the dynamics of water service provision in urban environments in the global South. In particular, INHAbIT will explore historical processes and transformations that have shaped water service configurations, the politics of socio-technical urban water supply systems and the socio-ecological processes shaping the urban waterscape. INHAbIT is innovative in that it takes an interdisciplinary approach and aims at developing new methodologies and conceptual approaches. To this aim, INHAbIT has identified three objectives, which combine theoretical, methodological and empirical elements: undertake a theoretical synthesis that brings urban political ecology perspectives into engagement with institutional bricolage; explore and test innovative methodologies for tracking informality and investigating socio-natural processes; undertake empirical work and building up a robust body of rigorously researched historical and qualitative data on natural, historical and institutional transformations that have shaped and continuously re-shape water service realities in Lilongwe (Malawi) and Maputo (Mozambique). While taking a critical approach, INHAbIT is also cognizant of the needs of policy makers and practitioners for solutions that work for serving with adequate water a growing population. The researcher, Maria Rusca, will explore the implications of INHAbITs research findings for policy and practice and disseminate accordingly. INHAbIT, thus, will be both scientifically innovative and policy relevant.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195274;656479;SiCWIRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Silicon Carbide Nanowires for Electronic and biosensing applications;1/04/2016;30/09/2017;;"SiC nanowires (NWs) combine the properties of 1D materials with that of SiC and devices based on SiC NWs would present concrete advantages. The main objective of the project is to develop the technology of SiC nanowire field effect transistors (NWFETs) and demonstrate devices suitable for two areas of application:
1) More Moore: Logic applications. SiC NWFETs have the potential of high temperature operation and eventually of efficient power dissipation and thus they can address main issues in semiconductor device scaling.
2) More than Moore: Biosensor applications. SiC exhibits superior to Si chemical stability and biocompatibility and SiC NWFET-based biosensors can thus, exhibit challenging performances.
Top-down technology approach (lithography and plasma etching) will employed to obtain, suitable material quality (residual doping lower than 1E17 cm-3, same carrier mobility as bulk material and if possible, in-situ doping for channel and contact regions).
The targeted performance of the SiC NWFETs is 200C operation, an Ion/Ioff ratio above 1E6, a subthreshold swing less than 200mV/decade and an electron channel mobility above 200 cm2V-1s-1. These electrical characteristics address the needs of logic applications while for biosensor applications are largely enough and can be relaxed.
The biosensing operation of SiC NWFETs will be shown by detecting different substances (DNA, heavy ions, phenyl groups). Towards this aim, a large part of the work will be devoted to the study of the relevant functionalization ways for SiC NW surfaces and stability of these surfaces to various aqueous solutions.
The main research work will be conducted in INPG while industrialization issues will be investigated in partner organization (CEA-LETI).
The fellowship will enhance the professional maturity of Dr. Zekentes with a consequent effect in his career by reaching a higher researcher-grade (Research Director, the highest one for Greek researcher) and higher academic positions.";138807;138807;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT POLYTECHNIQUE DE GRENOBLE;FR;;; 195331;656816;Oncoworm;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ONCOWORM: Using functional genomics in highly regenerative flatworms to find novel cancer genes;5/04/2016;4/04/2018;;This project will take direct action in exploiting the powerful planarian model system to achieve novel insights into the molecular processes underpinning oncogenesis and cancer. Based on the principle that biochemical and physiological functions of many genes are conserved across phyla we will identify planarian genes that control the migration, proliferation and differentiation of the highly proliferative pluripotent adult stem cells (pASCs). We will combine a bespoke specially designed partial irradiation assay, bioinformatic and expression based candidate gene identification and the capacity to perform RNAi based screens of gene function to identify novel genes controlling pASCs that are conserved in humans. Those novel genes of greatest promise will then be studied in mammalian cancer cell lines using the insight gleaned from planarians. This project brings together, for the first time, a world-class planarian laboratory with an eminent cancer cell biologist, Dr Kosaka, who will acquire all the expertise required to exploit the planarian system and at the same time transfer his extensive knowledge of cancer biology to the Aboobaker laboratory.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195360;656937;QuantMR7;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantitative MRI of the brain using magnetic resonance fingerprinting;1/09/2016;31/08/2018;;"Alterations in the intrinsic physical tissue parameters measured with magnetic resonance imaging (MRI), such as of longitudinal (T1) and transverse (T2) relaxation times, have been implicated in major neurological conditions. Although these differences have been noted as useful signs in image contrasts, parameter quantification has not been exploited as a marker for disease stage or for monitoring treatment efficacy.

Previous attempts to perform quantitative MRI protocols have suffered from sensitivity to system imperfections as well as infeasible, long acquisition times. Recently, a new approach called MR fingerprinting (MRF) has been developed for the estimation of multiple parameters at once, featuring a new dedicated acquisition strategy. The method has shown great promise as data can be acquired in clinically acceptable time, is relatively insensitive to system imperfections and has high accuracy. To date, only two dimensional datasets using a single acquisition strategy (balanced steady state free precession bSSFP) have been explored. Further, this was using a rather slow reconstruction algorithm at 1.5T. In addition, the technique has not been yet applied outside healthy volunteer groups.

In this project we aim to develop a 3D MRF acquisition for imaging the whole brain with optimized acquisition trajectories. We will compare different acquisition strategies, including strategies sensitive to magnetic susceptibility in the brain, previously unexplored. The sequence parameters will be optimized using a dedicated novel genetic algorithm. An accelerated reconstruction software using a novel algorithm will be developed using graphics processing units. Initial data will be acquired with new protocols at 7T and at 1.5T. Statistical parametric maps will be used to investigate group differences. The close interaction with clinical facilities will facilitate the prompt application to patient groups, including neurological, psychiatric and pediatric patients.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMAGO 7 FONDAZIONE DI RICERCA ONLUS;IT;;; 195310;656723;NPL;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Synthesis of Natural Product Like Compounds for Drug Discovery;1/03/2016;;;This proposal deals with the application of Dr. Francisco Cardona for a fellowship to work on the design and synthesis of new macrocyclic natural product like compounds (NPLs) which have potential in chemical biology or drug discovery at NUI Galway. A training programme has been designed for Dr. Cardona to enable him to broaden and deepen his professional knowledge and develop complementary skills that will mature him as a researcher. The project involves the innovative synthesis of new NPLs based on novel macrocycles. The main objective from the scientific point of view is to prepare new scaffolds that have not been explored to date and to generate compounds for screening in a wide variety of bioassays. This will determine if the scaffolds are relevant for developing therapies to cancer or infection, for example. There is a need for this research in that industry and academia have focused for a long time on a limited number of scaffolds and drugs have been based on a limited number of frameworks. In this research the applicant aims to increase the number of frameworks available and to also develop routes that are concise. Compounds will be evaluated for their biological properties within the project and managed for shipping to collaborating researchers for screening. Dr. Cardona will broaden and deepen his professional expertise, gain knowledge of screening and interpretation of biological results and of approaches in medicinal chemistry. This professional knowledge will increase the researchers capacity to contribute to related projects in industry or academic or research organisations later in is career. They will undertake a programme of complementary skills training to enhance relevance to future employers. The host is committed to ensuring that the relationship with the researcher will be conducive to successful performance in generating, transferring, sharing and disseminating knowledge and technological development.;175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;;; 195223;656082;DISAGROUP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Role of Groups in Complex Disagreement;1/04/2016;31/03/2018;;The research project DISAGROUP The Role of Groups in Complex Disagreement will investigate the phenomenon of complex disagreement in society from a philosophical perspective. Social epistemology has been mainly devoted to the study of peer disagreement (the kind of disagreement among individuals who share the same evidence and intellectual capacities). However, real-life disagreements such as long-standing religious, political or economic disagreements have a much more complex structure: the involved parties are not normally individual epistemic peers but groups that do not possess the same evidence or intellectual resources, they involve a lot of claims and are usually sustained not for the sake of knowledge but by elements such as faith, hate, intolerance or distrust. DISAGROUP aims to fill a gap in the philosophical literature by giving a general account of the structural elements that make most real-life disagreements so complex and difficult to understand, with a particular focus on the role played by groups in sustaining complex disagreements. In particular, DISAGROUP will address four main research questions: (1) Are the beliefs and other attitudes that ground complex disagreements beliefs and attitudes of groups with their own distinctive agency or by contrast of individuals that merely happen to believe the same thing? (2) Is complex disagreement better characterized in terms of belief or alternatively in terms of acceptance? (3) Can complex disagreement be characterized (at least partially) in terms of a difference in epistemic virtues among the disagreeing parties (groups) and, if so, what kind of virtues are they? (4) What is the rational response to complex disagreement? More specifically, does complex disagreement rationally compel groups to revise their beliefs or joint acceptances or does it also compel them to become more intellectual virtuous?;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195543;658057;HS-GLASSion;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Highly stable glasses applied for lithium ion battery electrolytes;1/08/2015;31/07/2017;;Lithium ion batteries (LIB) with a solid-state electrolyte component is one of the much desired goals for rechargeable energy sources since they provide with high safety, high reliability and high energy density. Inorganic glass-based electrolytes are very promising materials due to their higher ionic conductivity when compared to crystalline alternatives. Nevertheless, important concerns still have to be resolved and optimized. For instance, ionic conductivity in glass-based electrolytes continues to be poor compared to liquid electrolytes and their stability still lacks of long lifetime capability. In general, necessary innovative scenarios are needed as the next step forward in current thin film battery research. In order to improve performance and solve these issues in LIB's we propose, as the main purpose within HS-GLASS\ion, the addition of a new class of materials, the so called highly stable glasses (HSG). These glasses can achieve remarkable properties when prepared through vacuum deposition processes when tuning several parameters during film growth. This new discovery is well considered as an important development in glasses and supercooled liquids but still unknown in the area of energy storage. HSGs have higher densities which can help to easily create large homogeneous areas without any performance threatening artefacts. They are more resistant to temperature and vapor uptake which will increase chemical and structural stability of electrolytes. The lack of grain boundaries but the coinciding existence of short-range order will modify Li\ ion mobility achieving properties that have not yet been explored in battery research. The ability of tuning stability on HSGs will help boost interface engineering through gradient compositions between the electrodes and electrolyte. The outstanding properties of HSG's will help fulfill thin film technology needs and battery research current requirements.;172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;;; 195407;657195;MEROXRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding the fate of Arctic atmospheric mercury (Hg) deposition A Hg stable isotope investigation of redox processes and Hg re-emissions;1/04/2015;31/03/2017;;"Mercury (Hg) is a pollutant of global concern for human and ecosystem health. This is particularly true in the Arctic where indigenous populations are excessively exposed to dietary Hg from fish and marine mammal consumption. The deposition of Hg from the atmosphere to Earth surfaces and its re-emission via biogeochemical reduction processes determine Hg concentrations in Earth surface reservoirs, such as soils, snow, and runoff into Arctic lakes and surface Ocean. In order to predict the impact of anthropogenic Hg emissions on net atmospheric Hg deposition and ultimately Hg concentrations in biota, it is important to understand these deposition and re-emission processes. The reduction of deposited Hg2\ to volatile gaseous Hg0 and the oxidation of gaseous Hg0 to reactive Hg2\, which is rapidly deposited from the atmosphere, control the global fate of Hg. Major knowledge gaps concerning the mechanisms of these redox processes exist.
Different photochemical and non-photochemical Hg2\ reduction mechanisms were found to fractionate Hg stable isotopes in distinct, identifiable ways. Also, different atmospheric Hg0 and Hg2\ pools have been shown to have distinguishable Hg isotope signatures. Hg isotopes can thus provide new insights in the sources of Hg and redox transformation processes at the Earth-atmosphere interface, which are inaccessible by means of concentration and flux measurements alone. In the MEROXRE project proposed here we will combine the latest innovations in gaseous Hg measurements in porous media (soils, snow) with state-of-the-art Hg isotope techniques to investigate:
(i) Hg isotope fractionation of Hg2\ reduction and gaseous Hg0 oxidation in interstitial snow air and soil pores.
(ii) Hg isotope fractionation factors associated with net gaseous Hg0 re-emission fluxes from soil and snow.
(iii) the importance of gaseous Hg0 oxidation and Hg2\ reduction and re-emission for the global Hg cycle by incorporating the results in a global Hg isotope model.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195503;657741;socialog;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Social Capital, Institutional Accessibility and Local Governance;4/01/2016;3/01/2018;;The research proposal focuses on the study of the interaction between individuals' accessibility in contemporary institutions and their Social Capital (SC). The main premise of the proposal is that alienation from formal institutions creates a form of SC that works in a substitutive rather than a complementary way with the institutions and does not necessarily have positive societal externalities. In the first phase of the fellowship, a multi-disciplinary and innovative methodology will be applied in order to determine the exact conditions under which this form of SC is being developed and to measure the externalities it yields in a societal level. The second phase of the fellowship is devoted in exploring the implications of the results for local governance policy-making. In particular, it involves disseminating the findings and insights of the study to a Think Tank whose objective is advising local government councils.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF READING;UK;;; 195282;656519;ELSWIFLUOPRO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electrochemically Switchable Fluorescent Probes for Biological Applications;1/09/2015;31/08/2017;;In current drug development, the visualization of therapeutic-agent translocation to the cell interior represents one of the essential problems. The transport across cellular membranes is frequently executed by cell-penetrating peptides (CPPs), and the process is routinely studied with fluorescence microscopy when the CPP is attached to a fluorescent marker. Nevertheless, the use of existing labelled CPPs is connected with several drawbacks. Especially, bonding of CPPs to the external face of the cell membrane make interpretation of the translocation difficult and can result in false positive results. Therefore, the development of novel electrochemically switchable fluorescent probe for the detection of CPP translocation is suggested. In this project, a fluorescent organic dye will be coupled with an electro-controlled fluorescent quencher, which could be activated/deactivated in response to applied electric potential. As the electron transfer cannot occur through the cell membrane, labelled external CPPs would be switched off through photoinduced electron transfer, and fluorescence only of internalized CPPs could be studied. Reversibility of the system represents a remarkable advantage as it would allow repetitive on/off switching of the fluorescent probe.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ECOLE NORMALE SUPERIEURE;FR;;; 195220;656161;AutismRigidPercept;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigation and modification of atypical dynamic brain activity underlying perceptual inflexibility of autism spectrum disorders;1/05/2015;30/04/2017;;Perceptual and cognitive inflexibility is considered to underlie the repetitive and restricted behaviours of autism spectrum disorder (ASD). However, despite its severe effects on daily life of autistic individuals, the biological basis of these ASD core symptoms remain little known. In this project, I will investigate the neural mechanisms behind this fundamental mental inflexibility of ASD by examining neural activity during bistable perception, which is thought to be suitable for evaluation of such mental and perceptual rigidity. To detect neural responses from the brains of autistic individuals during such fluctuating perceptual experience, I will empirically calculate the energy landscape of brain activity from non-invasive measurements of brain activity and numerically simulate activity transition on the energy surface. Given the explanatory power of this method demonstrated by my preliminary data, this project is expected to provide the first empirical evidence for autistic impairments in dynamic brain activity that underlies the mental inflexibility of ASD. Furthermore, successful completion of this main project will provide insight for a novel non-invasive intervention protocol to mitigate such autistic cognitive rigidity, which will be subsequently tested within this research project. I believe that this project has the potential to provide a novel integrative perspective to understand autistic cognitive inflexibility and presents a promising approach to modify these relatively overlooked symptoms.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195291;656582;SAFE LIB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electro-thermal modelling of lithium-ion battery packs from the safety perspective;16/11/2015;15/11/2017;;"Lithium-ion batteries (LIB) are found in many applications such as consumer electronics, electric vehicles and airplanes. However, LIBs can be dangerous under some conditions and can pose a safety hazard since they contain a flammable electrolyte and are also kept pressurized. Despite the high safety standards being imposed and the embedded safety features, there have been many reported accidents as well as recalls done by some companies. Most accidents can be sourced to run away reactions, which could happen if the LIBs are overheated or overcharged. This is often accompanied by cell rupture and in extreme cases can lead to fire and explosions.

The Fellow has conducted her PhD on LIB run away reactions and investigated the effect different anode and cathode materials to enhance LIB safety through modelling, experiments and theoretical study of LIB cell. She will transfer such knowledge to the European host and combine with their extensive expertise in fire and explosion modelling to develop a thermal model to simulate the heat generation and dissipation within the battery pack. The research intends to bridge some important knowledge gaps concerning LIB safety and deliver a predictive tool, which can be used to enhance LIB thermal management from the safety perspective. Such a tool can aid the development of safer LIB cells and the optimisation of LIB packs balancing performance and safety requirement.

The specific objectives include:
- Develop and validate a thermal model that will predict the onset of runaway reactions (WP1);
- Extend the above model to predict potential ignition (WP2);
- Further extend the model to predict possible escalation from a single cell ignition to potential fire and explosion hazards (WP3);
- Validate the predictions with full scale test data giving particular emphasis to cell rupture and the propensity from ignition of a single cell to battery packs (WP4); and
- Conduct cases studies to formulate recommendations on LIB safety.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195369;656990;REDOxHEART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Role of Adipose-Tissue Derived wnt-ligands in the Regulation of Myocardial Redox Signalling;1/07/2015;30/06/2017;;Myocardial redox signalling is a critical regulator of myocardial physiology and a therapeutic target in cardiovascular science, while obesity seems to trigger myocardial oxidative stress. The non-canonical wnt signalling pathways (Ca2\-dependent (CDP) and planar cell polarity pathway (PCP)) are important in cardiac development and they are also involved in obesity (wnt ligands are involved in adipose tissue expansion), although their role in the adult myocardium is unknown. We propose to define the role of CDP and PCP in the regulation of myocardial redox state in the human adult heart. We will perform a) Clinical association studies using tissue from patients undergoing cardiac surgery to test for paracrine effects of adipose tissue on myocardial PCP/CDP regulation b) Studies using ex vivo models of human myocardium (trabeculae) to test the role of CDP/PCP in myocardial redox state regulation c) Cell culture studies using primary human cardiomyocytes to explore the mechanisms of these effects d) Animal studies using a novel transgenic mouse model to test causality of the associations. In this translational study we will explore for the first time the role of CDP/PCP in the regulation of myocardial redox signalling and evaluate its role in cardiac physiology. This work may identify novel disease biomarkers and therapeutic targets for the treatment of myocardial diseases.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195299;656657;TANYFEEDNEURONS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes;1/10/2015;30/09/2017;;Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and will identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and lead cause of death in Europe.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 195275;656480;AWWO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A world without objects: the metaphysics of indeterminacy in ancient philosophy, from Democritus to Aenesidemus.;1/06/2015;31/05/2017;;"The proposed project aims at investigating the metaphysics of indeterminacy in ancient philosophy. By relying on the aid of contemporary metaphysics (in particular, Van Inwagen's materialism and Merricks', and Stage-theory of material objects), the project will show that the metaphysics of indeterminacy was an important, yet neglected, part of ancient metaphysics, from the time of Democritus to that of Aenesidemus.
The project will deal with a variety of Greek philosophers, traditionally understood as subjectivists (this very general label as meant to include relativists, sceptics, infallibilists and nihilists). These are the following ones: Democritus, Protagoras and Gorgias, Heraclitus, the Socratic schools of the Cyrenaics (including later exponents of the school, such as Theodorus the Godless) and the Megarians (Euclides, Eubulides, Diodorus Cronus, Stilpo), Pyrrho and neo-pyrrhonism (Aenesidemus).
The project will demonstrate that, although in different ways, all the philosophers just mentioned adhered to a view of the world according to which either 1) objects of perception are indeterminate with regard to their properties or 2) objects in themselves are best understood as indeterminate items (in particular, on this latter view, objects as stable and unitary items are denied to be existing).
The project is both historical and philosophical, in so far as not only does it attempt to reconstruct the details of ancient conceptions of metaphysical indeterminacy, but it will also try to demonstrate the philosophical viability of those conceptions by drawing close parallelisms with current theories of metaphysical indeterminacy.
To appreciate the pervasiveness of metaphysical indeterminacy in ancient Greek philosophy is tantamount to providing a revolutionary insight in the history of ancient metaphysics (and of metaphysics tout court) by challenging the standard view that sees it dominated by Platos and Aristotles different, yet cognate, essentialisms.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Durham;UK;;; 195488;657627;PERMTHAW;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Permafrost thaw decadal responses to climate change;1/05/2016;30/04/2018;;"Permafrost soils contain approximately 1672 Petagram carbon (C), twice the amount of the current atmosphere, and constitute 50% of the worlds belowground C pool. Along with the current change in climate these high latitudinal soils experience increased temperatures, more than any other region, with permafrost degradation as a result. Such thaw of permafrost releases ancient organic matter that has been stored in the frozen soils for centuries. Following microbial degradation, this organic matter can be released to the atmosphere as carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), further influencing the climate systems. Thus, a changed climate leads to server alterations of the carbon (C) and nitrogen (N) balance in Arctic and high altitude ecosystems. However, research up to today has mostly focused on the impact of permafrost thaw and the time horizon immediately following this degradation.
The proposed project aims for understanding the future that lies ahead, following thaw and establishment of new non-permafrost ecosystems, and how the predicted climate variability will influence these soils on a decadal timescale. By using a natural occurring permafrost degradation transects, this project investigates how the C and N cycling changes following thaw. Moreover, by using laboratory incubation the project will provide unique insights of how these cycles will respond to the changing climate long after the formation of the new ecosystems, giving a decadal perspective on permafrost thaw.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Goeteborgs Universitet;SE;;; 195316;656748;KEME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Knitting early modern Europe: materials, manufacture and meaning;1/08/2015;31/07/2017;;The development of knitting was a key technological innovation for which there is little published scientific evidence. There are more than 100 knitted caps from the early modern era in museum collections worldwide - an astonishing number given the paucity of extant garments from the period. Despite their diverse locations, they have remarkable similarities in their materials and manufacture which illustrate trade in knitted caps as consumer goods in the emerging early modern European marketplace, demonstrate how knitting created new fashions for men indicative of rank and status, and facilitate theory on the cultural significance of the hat as an essential male accessory. My preliminary study of the caps tracks clear patterns in the data: five typologies are identifiable and when contextualised with pictorial and documentary sources, their cultural significance as functional and fashionable mens wear is clear. I believe the caps potential as indicators of the development and growth of knitting technology is valuable yet vulnerable. The caps are fragile and deteriorating, a process accelerated by each viewing, for which there is pressing and unsatisfied demand. I propose immediate rigorous scientific study (radiocarbon dating, microscopic examination, x-radiography, fibre and dye identification, and degradation analysis) and interdisciplinary research into contemporary sources to chart an economic map of early knitting, to define terminology for further scholarly work, and to develop theory about mens headwear in the 16th century. An online database will make the data accessible to scholars, museum pedagogues and craftspeople, who demand access to the caps. Journal articles, practical workshops and social media will disseminate my conclusions and my development of theory. I will give voice to an eloquent body of evidence about early modern knitting technology, which threatens to be silenced forever if scientific analysis is delayed.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;KOBENHAVNS UNIVERSITET;DK;;; 195268;656428;FIRSTBHs;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The formation of supermassive black holes in the early universe;1/10/2015;30/09/2017;;"Supermassive black holes (BHs) of more than a billion solar masses have been observed at z > 6 when the Universe was less than a billion years old. Forming such objects is highly challenging, as high accretion rates need to be maintained over very long time scales. Seed BHs with masses of 10^4 -10^6 solar masses, as predicted by the direct collapse scenario, provide a promising pathway to explain their presence. During this project, I will derive the mass distribution of the BHs to provide constraints on their masses and growth mechanisms which can tested with upcoming missions such as JWST and ATHENA. To achieve this goal, I will build up a statistical sample of high-resolution adaptive mesh refinement (AMR) simulations of massive primordial halos, following the dynamics of the gas from cosmological scales down to scales comparable to the solar system. The gravitational collapse initially forms a rapidly accreting protostar, which subsequently moves to the main sequence providing ultra-violet (UV) feedback and finally collapses to a massive BH. In the first part of the project, I will compute the impact of stellar feedback from the supermassive star and follow the time evolution of the mass accretion rates. Subsequently, the simulations will be extended by incorporating the X-ray feedback from the BH itself. Finally, scaling relations between the properties of the host halos and BH masses will be derived. This work will provide the first detailed assessment of the mass distribution of seed BHs, and their observational properties. This
is a substantial step forward to understand the origin of high-redshift BHs.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195528;657951;RareFunctions;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;RAREFUNCTIONS: The causes and consequences of spatial and temporal variation in rare traits.;1/06/2016;31/05/2018;;Rare species have long been the focus of conservation attention, but the commonness or rarity of particular characteristics or phenotypes is generally ignored. However, traits can also be rare, and evidence suggests that while rare traits tend to occur in rare species (and so are at greater risk of extinction), not all rare species have rare traits. Further, the diversity of traits present in a community (functional diversity) is closely tied to its function, and so rare traits may make essential contributions to ecosystem function and health. For example, predators may be rare in a system, but act as keystone species with effects across the food web. Given the possibility that rare traits make important contributions to ecosystem products and services and given their greater risk of extinction, it is imperative to explore this question of functional rarity. This project will help overcome the lack of a clear definition for functional rarity, the absence of geographical information on its distribution through space and time, and the need for experimental evidence tying the loss of rare traits to effects on ecosystems. This project aims to apply a system of classification to distinguish between different forms of functional rarity to a comprehensive database of plant diversity and trait values in French permanent grasslands. This will produce one of the most comprehensive inventories showing how functional rarity varies through space and time. In addition, RAREFUNCTIONS will use microbial microcosms to test how the loss of rare traits from a community alters ecosystem function. This proposal will establish baseline knowledge on the distribution of functional rarity in French permanent grasslands, a local hotspot of biodiversity and in decline, while also answering general questions about the causes and consequences of rare traits.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195208;656099;fetISC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterizing drivers of intestinal tissue maturation in vitro and in vivo;1/02/2016;31/01/2018;;One of the challenges in regenerative medicine is to generate adult intestinal stem cells (ISCs) from human induced pluripotent stem cells (hiPSC) in vitro in defined conditions. This will be important in order to establish intestinal cell transplantation therapies and a platform for neonatal disease modelling. These issues constitute the main goal of the proposal. The current protocols to direct intestinal differentiation from hiPSC impede their suitability for human transplantation purposes either because they require mice as tissue culture incubators (teratoma formation), long exposure to calf serum, or generate cells with fetal properties. The immature fetal intestine is distinct from its mature counterpart most notably by its absence of differentiated secretory lineages. Moreover the precise location and developmental stage from which ISCs are specified in fetal intestine as well as the mechanisms that govern the progression towards an adult epithelium remain to be elucidated. In order to generate adult ISCs from pluripotent sources it is instrumental to decipher the molecular mechanisms driving ISC maturation under physiological conditions. The project will be initiated with the fine mapping of ISC origin in the fetal epithelium using cell tracing techniques. Then I will characterize how fetal ISCs acquire adult properties at the molecular level. In the host laboratory we hypothesize that differentially expressed transcription factors are responsible for the unique characteristics of fetal and adult ISCs. Recently, using gene expression profiling comparing fetal and adult intestinal cells I have identified specific endodermal transcription factors overexpressed in the immature structures. I expect through the modulation of such factors to trigger the intestinal maturation. To ensure the transferability of the results into clinics I will combine studies with murine models and cells from human fetal and adult intestines.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195260;656377;Transnat_farright;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transnational nationalism. Far-Right Nationalist Groups in East Central Europe in the 20th and 21st centuries;1/10/2015;30/09/2017;;"The project will study networks of youth far-right nationalist organizations in East Central Europe, paying particular attention to the developments in Austria, Croatia, Hungary, and Poland. Using historical and anthropological methods, the study explores the transnational dimension of nationalist organizations: the networking of ideologies and tactics. It entails a combination of archival research, interviews, and participant observation during nationalist gatherings. In proposing a historical-ethnographic study of youth far-right nationalist groups, the project aims to fill the gap in existing scholarship, resulting from the lack of interdisciplinary dialogue, negligence of a historical dimension, and macro-perspective predominance. Inspired by the transnational history approach, it foregrounds the complex synchronic and diachronic - interactions between European nationalisms and studies agents of those exchanges, examining nationalist activists motivations and experiences. A combination of anthropological in-depth analysis and historical approach offers an original perspective by drawing parallels between nationalist activities against a multinational federative system, the Austro-Hungarian Empire, and the EU. It provides a critical tool for challenging unidirectional models of modernity and nationalism and for reflecting on the challenges to the European integration.
The project will be undertaken at the Institute for East European History, University of Vienna, under the supervision of Prof. Philipp Ther, a leading specialist in the field of transnational history. During the secondment at the Department of Gender Studies, Central European University in Budapest, I will explore the gender dimension of nationalist activism. The fellowship will constitute a fundamental step in my academic career, enabling me to develop a new field of research and expertise and to gain skills necessary to become an independent researcher and to lead my own research group.";178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195205;656044;ClauSeInTEL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Clausal Selection: Integrating Theoretical with Experimental Linguistics;1/09/2015;31/08/2017;;The nature of the relationship between a verb and its grammatical dependents is an ancient question in linguistics, tracing back to Aristotelian notions of the subject-predicate relation. A major debate in current theoretical linguistics is how to model this, and the standard view (that the relevant information is stored as part of the grammatical specification of the verb) has been challenged by the development of a new idea: that both the verb and its noun-dependents are embedded inside syntactic hierarchies of fundamentally grammatical elements (socalled functional categories encoding notions such as tense, aspect, definiteness and numerosity) and that it is the interaction between the functional category structures that embed the verb and the noun that is responsible for establishing the dependency. This viewpoint has allowed a new and empirically successful understanding of the relationship between a verb and its dependents, capturing how definiteness and grammatical number interact with aspectual categories across different languages. However, this new approach has never been applied to the other major grammatical dependency that verbs set up: clausal complementation. That is, the parallel relation between a verb and its clausal, as opposed to nominal, dependents. This project investigates, using interdisciplinary methods, whether these new theoretical ideas can be applied to this empirical domain, comparing two languages (Greek and English) whose clausal syntax is quite different. The objective is to both test the theoretical model in a new empirical area, leading to new findings about how clausal embedding works syntactically, and to determine how best to develop and extend the model to domains that it was not designed for. The action requires extended training in experimental methods and design (both behavioural and neurolinguistic), statistical analysis, development of systematic theoretical models, as well as interaction with a non-academic partner.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195276;656485;SPIN3;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spin triplet pairings in ferromagnet Josephson junctions;1/04/2015;31/03/2017;;"For a long time, the coexistence of conventional superconductivity and ferromagnetism was believed to be impossible. Cooper pairs in normal superconductors are formed by two electrons with antiparallel spins in a singlet configuration while ferromagnets favour parallel alignment of electron spins. In 2001 it was theoretically predicted that under certain conditions both phases could coexist in hybrid structures, giving rise to a race for the discovery of an entirely new kind of superconducting electron pairing state in which the electrons are in the triplet state. The novel hypothesis of this Action relies on the fact that triplet pairs can be formed combining ferromagnets, normal metals and superconductors into hybrid Josephson junctions, and are stable enough to be used to carry spin information in addition to dissipationless charge transfer, which will represent an enormous improvement in comparison to the presently established spin-singlet-based devices.
This Action consists of two supplementary stages starting from the maximization of spin-triplet current densities in hybrid ferromagnet junctions (materials science) to the understanding of the basic mechanisms of the spin triplet pairs and the nanofabrication of hybrid Josephson junctions in which the spin triplet supercurrent will be controlled (condensed matter physics). Once the objectives of this Action will be achieved, besides its inherent immediate impact on spintronics and condensed matter, the generation of a radically new technology will emerge. This new technological paradigm, the superconducting spintronics , will take advantage of the unique properties of the two macroscopic phases that were believed to be incompatible and has the potential to overcome significant limitations of logic circuits based separately on superconductivity and spintronics. This experimental action has been built around a multidisciplinary research and innovation project which will be hold at the University of Cambridge.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195302;656690;GOMB-TBI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Causes and consequences of alterations in cerebral glucose metabolism in Traumatic Brain Injury;1/11/2015;31/10/2016;;Traumatic Brain Injury (TBI) is the leading cause of death and disability in young adults. Hours or days after the primary injury, secondary injury will develop. This secondary injury is responsible for most in-hospital deaths after TBI. Early interventions to prevent secondary injury are currently targeted at reducing intracerebral pressure and promoting cerebral blood flow (CBF), aiming to improve brain oxygenation and reduce ischaemia. However, there is increasing evidence that other mechanisms besides ischaemia are important in the development of secondary damage. Because our brain depends on glucose for functioning, alterations in cerebral glucose metabolism provide insight into the causes of secondary brain damage. The influence of plasma glucose has been studied, but the relation between body and brain glucose metabolism after TBI is unclear. In addition, there are indications that local neuroinflammation influences local glucose metabolism. New techniques, such as positron emission tomography (PET) with 18-Fluorodeoxyglucose (18FDG) and cerebral microdialsyis, allow detailed study of brain metabolism after TBI. During this project we aim to study the causes and consequences of alterations in brain glucose metabolism using 18FDG PET and microdialysis. We will study the influence of alterations in oxygen supply, neuroinflammation and body glucose on alterations in glucose metabolism. Thereafter, the consequences of alterations in glucose metabolism on brain tissue will be studied, using structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). This will provide novel insights into the underlying mechanisms of secondary injury following TBI and its long term consequences. These data should provide a basis for the design and assessment of future neuroprotective therapies.;97727,4;97727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195284;656528;CortexVisionBehavior;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neocortical circuits underlying visually-guided behaviors in mice.;17/03/2016;16/03/2018;;"Many of our most common behaviors, such as reaching out to grasp an object or turning towards something of interest, require that we transform visual information into a representation that guides action. In humans and other mammals, key steps in this transformation take place in the cerebral cortex, by the cooperative action of multiple cortical areas. How does this cooperation occur? The classical hypothesis holds that cortical areas act in series, each performing a unique step of the transformation and passing on the result, like workers on an assembly line. In an alternative hypothesis the transformation occurs in a distributed fashion, with multiple cortical areas participating jointly in each step. In this hypothesis each area may function more like people lifting a table together by its sides.

To test these competing hypotheses, I propose to record simultaneously from populations of neurons in six key cortical areas in mice performing a visual discrimination task. The task is designed to separate and quantify the contributions of each area to visual perception, decision-making, and action. The results will distinguish between the two competing hypotheses and reveal the distinct or shared roles of each cortical area. Then, I will put these conclusions to the test by silencing neurons in each of three areas and comparing the effects of inactivation on behavior. Together these experiments will reveal the fundamental mechanisms of how cortical circuits cooperate to produce visually-guided behaviors.

I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Kenneth Harris and Matteo Carandini.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195252;656338;MITONUC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The evolutionary and ecological implications of mito-nuclear epistasis;1/10/2015;30/09/2017;;The main hypothesis of the proposed research is that, contrary to common and long-standing belief, mitochondrial genetic variation is functional and plays a key role in evolutionary adaptation. I suggest that a novel understanding of selection on mtDNA can derive from simultaneously considering sex-specific selection and genetic interactions between mtDNA and nDNA. Because males are a genetic dead-end for mtDNA, mtDNA mutations that are detrimental for males but beneficial for females will spread. This will generate a male-specific genetic load (the mothers curse). Further, the main energy producing pathway in eukaryotes (the OXPHOS pathway) is built collectively by products of the mitochondrial and the nuclear genome. Thus, mtDNA and nDNA are potentially entangled in an intricate web of epistatic interactions that dictates organismal metabolism. The proposed research is built upon a series of interrelated parts, and will use a very amenable insect model organism and employ a range of different research methodologies. Specific aims of the proposed research is (1) to assess the effects of mito-nuclear genotype on key life history traits such as metabolic rate and test whether these effects are sex-specific in line with the mothers curse and (2) to test the hypothesis that mito-nuclear interactions promotes the maintenance of polymorphism in mitochondrial genome through negative frequency dependent selection. This research will have a range of biological implications, ranging from applied medical genetics over our use of mitochondrial genetic markers in population genetics/biology to speciation and our understanding of thermal adaptation to climate change.;185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Uppsala universitet;SE;;; 195259;656370;SF-magnetic-stars;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The impact of superfluidity and superconductivity on the magneto-thermal evolution and X-ray observations of neutron stars.;1/06/2015;31/05/2017;;"In the last decades, X-ray astronomy provided a wealth of information on the neutron star thermal history, surface temperature distribution, surface magnetic field strength, outburst and flaring activity. It has been recently shown, that many of these different observational properties are deeply influenced by the evolution of the magnetic field and temperature in the neutron star interior. Our understanding of the magnetic field evolution is however still incomplete, as these 2D numerical simulations completely neglect the field evolution in the core.
This project will study the magneto-thermal evolution of neutron stars with magnetic fields treading both the core and the crust, incorporating in a consistent way the effects of ambipolar diffusion and superfluidity/superconductivity. This research will explore also models where superconductivity is limited in shells, which are confined in the outer core. They are expected when the core's magnetic field is so strong, above 10^{16} Gauss, to destroy superconductivity. The magneto-thermal evolution will be studied by using 2D numerical simulations, which solve simultaneously the induction equation and the heat transfer equation.
The complex magnetic field which results from the magneto-thermal evolution may describe the configuration expected in a flaring magnetar, where quasi-periodic oscillations (QPOs) have been observed. This project will study the QPOs of these complex magnetic field configurations, by using perturbation methods. We will develop a computational framework to determine the properties of seismic vibrations on magnetar's models with any magnetic field topology.
The results of this research project and the combined information available from thermal history and magnetar QPOs will be used to determine, by using independent astrophysical observations and dynamical processes, the physical properties of highly magnetized neutron stars as well as to shed light into the equation of state of dense matter.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE ALICANTE;ES;;; 195513;657835;SugarOsmoSignalling;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Analysis of sugar- and osmo-signalling mechanisms in cell wall integrity maintenance;16/03/2016;15/03/2018;;"Cell walls provide plant cells with structural support during growth and differentiation as well as with protection against environmental stress. Cell wall composition and structure is adapted to these functional requirements by a dedicated mechanism to maintain cell wall integrity (CWI). The available evidence suggests that the CWI mechanism is an important regulator of cell wall and carbohydrate metabolism and that signalling of sugar levels and osmotic conditions is vital for its function. Furthermore, interdependencies between pathogen defence and the CWI mechanism are becoming apparent.
By performing a forward genetic screen in Arabidopsis, I will identify novel components involved in sugar-signalling in the context of CWI maintenance and pathogen defence. Using a combination of genetic mapping and next-generation sequencing, I will determine the identity of the components, whose specific activities will be identified through targeted functional analyses. In the second part of my project I will determine functions of the signalling metabolites trehalose-6-phosphate and glycerol-3-phophate in CWI maintenance and analyse the osmo-sensitive regulation of these functions. After characterizing time-dependent quantitative changes in metabolite levels and related enzyme activities upon impaired CWI and in combination with osmotic support, I will examine specific functions of metabolites / enzymes by analysing developmental, hormonal and structural responses in Arabidopsis overexpression and knockout lines.
This project takes advantage of CWI maintenance involvement in a variety of biological processes to identify signalling components and osmo-sensitive mechanisms for the coordination of carbohydrate metabolism with cell wall metabolism and pathogen defence. The knowledge generated in this project will provide novel functional insights into metabolic processes relevant for facilitating bioenergy production and increasing the yield of food crops.";208400,4;208400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU;NO;;; 195286;656540;EARMEDCASTILE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The formation of the state in Early Medieval Castile: craft production and social complexity;8/07/2015;7/07/2017;;"The main goal of the project is to analyse the emergency and the collapse of states in the Early Middle Ages through the study of production and distribution systems, which are consider a marker of social and political complexity. The project is based on two main axes: first at all, an interdisciplinary approach to the analysis of pottery would have the capability of revealing the political background of economic exchange. And even if this approach has been successfully applied to the study of process such as the end of the Roman Empire, at the same time our knowledge about the formation of state in South of Europe is very limited. Secondly, the North of Iberia represents an excellent case study for investigating the transformation of political structure in Early Medieval Europe, taking into account that in this scenario five different states rose and collapsed within only five centuries.
Production, distribution and consumption systems would be analysed, in order to highlights evidence for social and political complexity related with the emergence of states. In practical terms, early medieval pottery from 14 sites located in the Old Castile would be studied by Dr. Francesca Grassi, PhD on Medieval Archaeology. The main steps of the project would be (a) the identification of the main workshops located in the upper Ebro valley in early medieval times; (b) the analyses of consumption patterns, by combining pottery studies with bioarchaeological and palaeodiet evidence; (c) the definition of political trends at a local scale and the change of scale that determined the structuration of central powers taking into consideration the distribution systems.
The results of the Spanish case studies will be discussed with reference to previous studies carried out in Italy by the candidate, with the aim of inserting the project in a European dimension; this would be achieved by enhancing the existing dialogue between two research groups, GIPyPAC (UPV/EHU) and University of Siena.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA;ES;;; 195473;657595;OPEDGP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Omics Phenotyping of Endocrine Disease in the General Population;1/08/2015;31/07/2017;;Metabolomics is a relatively new technology that provides information about levels of human metabolites, the low molecule products at the end (downstream) of the metabolic pathways of human physiology. In theory, metabolite profiles may more closely reflect the clinical phenotype and thus potentially improve risk prediction. Another advantage is that that they can be performed on non-invasive biofluids like urine. Several metabolomics studies have suggested that the metabolite profile of an individual can be used as a predictor of type 2 diabetes. However, evidence from large-scale population-based studies with comprehensive phenotypes of diabetes and thyroid disease is limited. The aim of the project is to identify urine metabolite profiles associated with risk of diabetes and thyroid disease and to investigate pathogenetic pathways by identifying genetic determinants of these metabolites. The project takes advantage of the long tradition of population-based and registry-based epidemiological research in Denmark. The experienced researcher will complete a training program supervised by two recognised Danish research institutions with complementary expertise in the fields of epidemiology and genetics, respectively. Hereby the experienced researcher will achieve competences in the field of statistical modelling of epidemiological data with repeated measures and use of the unique Danish registries for research. Furthermore, during the secondment at the partner institution the experienced researcher will receive training in genetic epidemiology. In return, knowledge of metabolomics will be translated to the beneficiary and partner organizations. It is expected that the results will provide novel insights into the pathophysiology of diabetes and thyroid disease and identify novel biomarkers to improve risk prediction in individuals.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;REGION HOVEDSTADEN;DK;;; 195377;657017;LOGIVIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The logics of information visualisation;1/10/2015;30/09/2017;;"Information visualisation is an essential tool in data-science, but the lack of a theoretical foundation currently prevents visualisation science to make substantial progress and develop solutions for the epistemological challenges posed by Big Data.
Starting from the current state of the art in formal logic and the philosophy of information, the prospects of a new foundation for information visualisation are explored. This should lead to a model of the information-lifecycle in visualisation that sheds light on trade-offs in design decisions, gives a unified account for reasoning and communication with visualisations, and explains why and how information-visualisation allows us to climb the Data-Information-Knowledge hierarchy.
Given the epistemic challenges in science and in policy-decisions, substantial attention is also devoted to what can go wrong with the use of information-visualisation, which requires the development of an account of mis- and disinformation, and of fallacious reasoning based on computer-generated representations of data.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195190;655914;MICROCHANGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Emergence of pathogenicity in the sea: altered host-microbe interactions in the face of environmental change;1/08/2015;31/07/2017;;"Marine ecosystems are centrally important to the biology of the planet but they are at risk. The number of disease outbreaks in marine organisms is increasing, most likely caused by climate change and eutrophication. It is also established that these anthropogenic effects alter the interactions between hosts and their microbiome, specifically leading to a breakdown of host-symbiont relationships and to shifts in the diversity of host-associated microbes.
It is not clear however, how this is causally connected to the increased emergence of pathogens under environmental stress. This research project will establish this link by directly testing whether pathogens evolve from resident bacteria within the host-associated microbial community or whether shifts in the original microbial community facilitate the invasion by pathogens. This will be studied in a model system consisting of the sea anemone Nematostella vectensis as host, and its associated microbes, with a focus on vibrios. After the host-specific Vibrio population structure in the wild has been determined, WP1, experiments will be conducted in the laboratory testing the stability of the host-microbiome relationship under a range of environmental stressors. The role of the microbiome in protecting against the invasion of pathogens will directly be tested, WP2. In WP3, pathogen evolution will be followed in real time. Effects of the microbiome on interactions with (non-)pathogens will be separated from host effects. Particular attention will be given to the changes in the genome of vibrios, which can be connected to an increase in virulence, and to changes in gene-expression of both, hosts and the microbiome.
This multidisciplinary approach, combining the strength of microbial ecology, experimental evolution, and genomic studies, will significantly contribute to our understanding of host-microbe interactions, particularly focusing on the selective forces and ecological conditions that promote pathogen emergence.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL;DE;;; 195322;656775;GLUCOTOX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Does reducing ?-cell glucotoxicity increase the hyperglycaemia-lowering effect of physical exercise in type 2 diabetes?;1/07/2015;30/06/2017;;"Hyperglycaemia in type 2 diabetes (T2D) doubles mortality and arises due to failure of pancreatic ?-cell insulin secretory function to overcome insulin resistance. Exercise reduces hyperglycaemia by improving insulin sensitivity and ?-cell function; however, the variability of this beneficial effect is huge and is associated with high blood glucose and poor insulin secretion. Hyperglycaemia increases interleukin-(IL)1? levels causing ?-cell death and insulin secretory dysfunction (glucotoxicity), and these phenomena are all elevated in T2D and are also augmented by IL-6, which alone is not toxic to ?-cells. Interestingly, blood IL-6 levels are not only increased in T2D but are also increased following exercise due to secretion from muscle. Therefore the huge variability in the adaptation to exercise may be due to muscle IL-6-induced enhancement of IL-1?-induced ?-cell dysfunction. Thus, exercise may be detrimental to T2D patients with ?-cell glucotoxicity. Our objective is to determine the independent and interactive roles of IL-6 and IL-1? in the adaptations to exercise in T2D. We will achieve this by integrating the human physiology expertise of the Experienced Researcher with the transgenic mouse model expertise of the Supervisor to create a bench-to-bedside approach from which both the host institution and the experienced researcher will gain from in the future. Innovative muscle-specific IL-6 knockout mouse models and clinical anti-IL-1? drug treatment approaches will be used to ultimately increase the knowledge of how IL-6 and IL-1? interact, making it possible to optimise exercise therapy for all T2D patients, including those who would otherwise be classified as a non-responder.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195193;655938;ZEPHYROS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The dawn of writing in Western Mediterranean: a comparative approach to the Iberian epigraphic corpus;15/09/2015;14/09/2017;;"This project proposes a study of all known Iberian inscriptions (about 2.000 documents dating from the 5th century BC to the 1st century AD) in a comparative and interdisciplinary perspective. The study of the Iberian corpus will be set in a broad cultural context, including the rise of the first Western written traditions and their linguistic and cultural contacts. I will focus on issues such as the relationship between text and object, the Iberian adoption of exogenous epigraphic models (mainly Phoenician/Punic, Greek and Latin), and the level of literacy within the male and female spheres of this society.

Although the Iberian language in not yet fully deciphered, its epigraphic texts represent a cornerstone of the ethnological and cultural understanding of the protohistoric peninsular peoples and their insertion within the Mediterranean world. For the time being, however, there is no comprehensive study of the Iberian corpus, which has grown considerably over the past decades. On the other hand, there has been a tendency to study the Iberian world and its written culture in an overly isolated way, without sufficiently considering the panorama of neighbouring territories, which provide significant parallels.

The specific objectives of this project can be synthetized as follows: publication of the entire corpus of Iberian inscriptions according to current academic criteria, including a digital open access version; linguistic analysis of these texts with a special attention to the cultural context in which they were produced; study of the Iberian written culture in a broad cultural context, including neighbouring territories such as Northern Africa. This project will therefore contribute to the understanding of the Iberian language as well as the circulation of cultural models within the Western Mediterranean. It will ultimately represent an innovative step toward the comprehension of the birth of European identities.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE PARIS-SORBONNE (PARIS IV);FR;;; 195296;656607;DC FlexMIL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Development and Control of Flexible Mode-locked Integrated Laser;1/01/2016;31/12/2018;;This proposal aims at the development, characterization and control of a novel class of high repetition rate ultra-short pulse lasers featured by stable, flexibly shapeable emission properties combined in an integrated format (i.e. on chip). The associated benefits in terms of cost, size, and power consumption paired with the intrinsic flexibility are unquestionably significant characteristics to fulfil the dynamic needs of numerous sophisticated applications in the broad areas of metrology, telecommunications, microchip-computing etc., and will in turn enable to finally bring these innovative integrated lasers to the public market. By exploiting a high-Q microring resonator, a novel mode-locking approach named filter driven four-wave mixing (FD-FWM) will be used to achieve stable high-quality spectral emission. Enabled by this scheme, we will investigate and exploit the interesting effect of higher-order modulation instability dynamics (a higher-order characteristic of the mechanism responsible for laser mode-locking, not yet explored), to control and shape the emission as well as the noise properties of the proposed integrated laser device. In particular this will be achieved by dynamically controlling the main cavity dispersion of the system via incorporated specially designed Bragg grating waveguides. In parallel with the investigations on the controllability of the laser emission, the integration of the whole device will be pushed forward by designing and fabricating microring resonators based on silicon (oxy)nitrite technology as well as by developing a novel miniaturized laser scheme based on semiconductor optical amplifiers. The external optical control possibilities of the laser scheme proposed here will be exploited with a view to synchronize two lasers, a highly important achievement for next generation multi-source telecommunication networks.;255349,8;255349,8;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY OF GLASGOW;UK;;; 195269;656441;Carnap and the Limits of Metaphysics;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Carnap and the Limits of Metaphysics;31/08/2015;30/08/2017;;"This projects overall objective is to use state of the art research in the formal theory of knowledge to advance our understanding of the scope and limits of metaphysics. Specifically, the project will argue that the most important threat to the value of metaphysics comes from epistemic arguments given by Carnap, and that responding to these arguments requires drawing on considerations from formal epistemology.
The master argument that will focus this project draws on Carnap's (1928) epistemic critique of metaphysics:

1. No possible evidence can justify a metaphysical statement.
2. If no possible evidence can justify a metaphysical statement then we can have no justification to believe a metaphysical statement.
Conclusion: We can have no justification to believe a metaphysical statement.

The deliverables will be six papers published in leading journals. The first will argue that critiques of metaphysics based on semantics do not succeed. The second will argue that epistemic criticisms of metaphysics are effective, specifically Carnap's. The third will defend premise 1, arguing that the rationalist renaissance of recent years has done little to undermine the relevant empiricist thesis. The fourth defends premise 2 as applied to the question of ontology (what exists?), arguing that the non-empirical considerations used by objective Bayesians can be applied to metaphysics. The fifth criticizes premise 2 as applied to the question of modality (what it necessary?), arguing that non-empirical considerations cannot help us determine the gap between the necessary and the contingent. The sixth develops the anti-realist theory of modality that follows, arguing that it makes best sense of the core intuitions of both sides of the argument.
These deliverables will expand the ER's core strengths into metaphysics, re-integrate him into Europe and establish him as one of the leading European experts in formal epistemology and the methodology of metaphysics.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITY OF LEEDS;UK;;; 195261;656378;INTERFACIAL REACTIONS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Atomic-scale investigation of structure, diffusions, and kinetics of Al2O3/MgO reaction interfaces during spinel growth;1/05/2015;30/04/2017;;Much of our understanding of the evolution of the earth and other planets comes from analysis of minerals and rocks. In order to read the abundant information about the formation of these planets contained within them, the structure and composition of the minerals and rocks must be determined. Furthermore, the relationship between the mineral structure and the formation conditions needs to be corroborated via laboratory experiments. A typical case of mineral formation is reaction rim growth in which a new phase forms at the interface between two types of minerals. The phase resulting from the reaction of the minerals reflects the initial formation conditions. In the proposed research, MgO (periclase) will be deposited on Al2O3 (corundum) using pulsed laser deposition (PLD), and annealed at different temperatures. With this approach, the different growth stages of MgAl2O4 (spinel) phase formed at the reaction interfaces will be assessed. A combination of electron backscatter diffraction (EBSD), focused ion beam (FIB) and low kV argon-milling will be used to prepare site- and orientation- specific specimens for examination in an electron microscope. A state-of-the-art aberration-corrected scanning transmission electron microscope (STEM) with sub- resolution will be employed to directly resolve the actual atomic structure of reaction interfaces for the first time. Electron energy loss spectroscopy (EELS) in the STEM will be used, also for the first time, to directly reveal the elemental distributions and bonding states across the interfaces, resolving the actual atomic scale sequence of phase changes. Furthermore, electron beam excitation allows the investigation of the dynamic processes at the reaction interface. Finally the interface structure in different growth stages will be compared, therefore the relationship between the interfacial reactions and the growth conditions will be fully understood.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195345;656872;INAME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Imaging nucleic acid metabolism in cells;4/01/2016;3/01/2018;;In this project I, Pawan Kumar, a Nucleic Acid Chemist seek to team up with a pioneer in Nucleic Acid Chemistry and Biology (Professor Tom Brown) to carry out a highly interdisciplinary study at the University of Oxford to obtain deeper insights into DNA and RNA synthesis and metabolism in living cells and its application to cancer research. I propose to detect and quantify nucleic acid synthesis in proliferating cells by fluorescence without the requirement for toxic metal ions or antibodies. Earlier known methods such as [3H]thymidine and 5-bromo-2'-deoxyuridine labelling are either slow and labour intensive or require the use of harsh conditions. Incorporation of 5-ethynyl-2'-deoxyuridine into newly synthesized DNA and its subsequent detection with an azide derivative of a fluorescent dye under copper catalyzed alkyne azide cycloaddition (CuAAC) reaction conditions presents a better alternative. However, cytotoxicity of copper salts restricts its use for living cells. I will use the strain promoted alkyne azide cycloaddition reaction, Diels-Alder reaction, and inverse electron demand Diels-Alder reaction to study cellular DNA and RNA. None of these reactions require the use of toxic metal salts. I will develop the conditions under which both DNA and RNA will be stable, so that it will be possible to isolate intact fluorescent nucleic acids from cells for detailed analysis. I will prepare the modified nucleosides and use them to label newly synthesized DNA and RNA in cells enabling their detection by reaction with fluorophores by using metal free click ligation reactions. The study will provide a better understanding of the mechanisms regulating DNA replication and the interplay between transcription and DNA replication. In the project I will develop techniques to provide information on the toxic effect of antimetabolites used commonly in anti-cancer therapies, and for identifying the mechanisms of viral replication and understanding the viral life cycle.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195237;656262;QTMODEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantitative Motor Control for Decision Making;1/07/2016;30/06/2018;;The overall goal of this project is to provide a theoretical context encompassing motivation, motor control theory and motor decision-making. How does the brain relate incentive motivation to motor behaviour? How are these principles altered under Parkinsons disease (PD)? The fact that three of PDs major motor symptoms: bradykinesia, akinesia and hypokinesia are consistent with a lesser than normal motor invigoration, emphasizes the relationship between motivation and movement, strongly suggesting that PD may be reviewed as a disorder of motivation. This project is concerned with the two major quandaries impending to systematically test this hypothesis: the absence of a normative context relating motivation to motor control theory and the lack of an independent scale of incentive motivation. Therefore, we propose a novel unifying model called Quantitative Motor Control for Decision-Making (QTMODEM) to characterize motor processes as a function of incentive motivation for different kinds of movements. In other words, the QTMODEM intends to formalise the relationship between the selection of motor parameters and an independent metric of motivation derived from electro-encephalography. We will first quantify this relationship with a series of psychophysics experiments with healthy participants by varying two factors: the nature of their movements and the participants level of incentive motivation. Second, we will perform experiments with PD patients to gain a quantitative insight into their dysfunctional relationship between motivation and movement statistics. Third, we will build the QTMODEM based on the dynamics of a trade-off between motivation and motor costs, and optimal feedback control theory. Unlike previous models, we predict that the incorporation of motivation into the QTMODEM, will provide the proper normative context for the characterization of the dynamics between motivation and the selection of motor parameters, both under normal and PD conditions.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitat Pompeu Fabra;ES;;; 195354;656898;INVLOCCY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Invariants of local Calabi-Yau 3-folds;1/06/2015;31/05/2017;;"The study of Gromov-Witten (GW), Donaldson-Thomas, and stable pair invariants of Calabi-Yau 3-folds X forms an active area of research for geometers and physicists. These invariants play a central role in string theory and have relations with many branches of mathematics including number theory and representation theory.
I am interested in questions of enumerative geometry on algebraic surfaces S. Invariants of the total space X of the canonical bundle over S can be used to answer classical enumerative questions on S. Two recent developments in stable pair theory are: (1) A better understanding of stable pairs on X not contained in the zero-section S. (2) Refinements of stable pair invariants.
The first theme of my project is the study of stable pairs on X not contained in S in relation to enumerative questions. For Fano surfaces, GW invariants with sufficiently many point insertions are enumerative. By the GW/stable pairs correspondence these are equal to certain stable pair invariants of X. When the curve class is not sufficiently ample, the stable pair count may include stable pairs on X not contained in S. I propose to compute such contributions in order to obtain curve counts on S outside the ample regime.
The second theme of my project is the study of refined stable pair invariants. I intend to relate the refined topological vertex appearing in the physics literature to refined invariants in the mathematics literature.
Since stable pair invariants are often easiest to calculate of all the invariants of Calabi-Yau 3-folds, I expect this leads to new curve counting formulae and new calculations of refined invariants.
Utrecht University, housing one of the leading schools in geometry in Europe, and Prof. Faber, one of the world's leading experts on moduli of curves, provide the perfect location and supervisor for this project. The diverse expertise of the members of the Mathematics (and Physics) Department at UU allow me to explore links with other areas.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT UTRECHT;NL;;; 195244;656300;PERS-RELICT-CLIM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The persistence of relict populations under climate change;1/02/2016;31/01/2018;;"The rapid change in the Earths climate is predicted to disrupt the conditions which determine the distribution of tree species, with the most dramatic impacts at species range edges. At the trailing-range edge, empirical knowledge of the structure and performance of populations is very limited despite its essential importance for accurate prediction of species distribution and conservation of species diversity. Here, I hypothesize that the trailing-range edge is partly comprised of a relict structure of populations that can stabilize the range-edge of tree species. Through trait-based ecology and combining field, experimental and molecular approaches I aim to disentangle (1) the habitat, functional, genetic and demographic structure of trailing-range edge populations; (2) the mechanisms of local adaptation in early life stages; and (3) the associations between functional traits, demographic performance, habitat conditions and the relict status of populations. PERS-RELICT-CLIM is the first project designed to gain a complete understanding of trailing-range edge structure and functioning and potential of populations for persistence under global climate change.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF STIRLING;UK;;; 195245;656306;MecaMorphEME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Four-dimensional physical modeling and numerical simulation of the early mouse embryo morphogenesis.;1/09/2015;31/08/2017;;"The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine. Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown. Early mouse embryos self-organize by a succession of cell divisions, deformations and rearrangements, leading ultimately to the specification of two distinct cell lineages, segregated in inside and outside layers. Mechanical forces are therefore as important as biochemical activity in this process and precise 4-dimensional imaging of cells within the embryo reveals intense surface dynamics, regulated by contractile and adhesion proteins. However, our understanding of early embryos development still lacks a precise physical model integrating a dynamic description of the mechanical forces controlling cell shape and cell-cell adhesion.

I will design a 4D physical model of the early mouse embryo providing accurate cell dynamics predictions. Cell shapes are primarily controlled by the actomyosin cortex and they will be described using recently developed cortical active shell theories. To represent accurately cell-cell adhesion dynamics, I will consider the crosstalk between cortical and adhesion proteins activities. Importantly, this model will be designed in close collaboration with an experimental group expert in the biophysical characterization of the mouse embryo, to incorporate measured mechanical parameters and molecular regulation mechanisms. Our model will be refined through cycles of theoretical predictions and experimental validations to uncover the principles of early mammalian embryos development and, more specifically, the mechanism of cell internalization at the 8 to 16 cells transition. This interdisciplinary project, at the interface between physical modeling and developmental biology will provide a unique and accurate biophysical framework for understanding the morphogenesis of early mammalian embryos.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;;; 195309;656632;ECONOMY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Plant Ecology for Nitrous Oxide Mitigation and Sustainable Productivity;1/02/2016;31/01/2018;;Agricultural soils are the dominant source of nitrous oxide (N2O), a potent greenhouse gas as well as a major cause of ozone layer depletion. Recent findings show that combinations of plants with complementary root traits can increase nitrogen (N) uptake leading to lower N2O emissions. Based on the microbiology behind soil N2O emissions and on plant-trait based ecology, this project aims to build on this finding and develop a novel N2O mitigation strategy. We aim to reveal how plants and plant interactions via their traits and trait combinations can be used to reduce N2O emissions in a context of climate change related disturbances (drought and intense rainfall). Starting with microcosm incubations using monocultures of different plant species, we will quantify the relative importance of specific plant traits as means to regulate N2O emissions. An ensemble of inter- and multi-disciplinary techniques will be applied to analyse the ecological and agronomical plant characteristics of potential relevance as well as the plant-specific microbiological communities of importance for the N-cycle. Subsequently, greenhouse mesocosm experiments will be used to expand the acquired knowledge to cover interactions between plants and stresses induced by climate change factors. A meta-analysis of published and unpublished datasets will allow further elucidation of specific and interactive mechanisms, differentiated by environmental and management factors and to include studies over longer time frames. Finally, the generated results will be used to calibrate and validate a process-based model in order to extrapolate our findings to regional levels. Deliverables will be peer-reviewed papers, new experimental data on a new N2O mitigation strategy, improved model tools to simulate mitigation and reports to policy makers and stake holders on a N2O mitigation strategy that concurrently maintains / increases agricultural production. Overall, ECONOMY will guide future N2O mitigation policy.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195458;657505;MTT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;How does future thinking work? Uncovering its evolutionary and developmental origins;1/09/2015;31/08/2017;;"Time is always moving forward. However, humans can remember past events (e.g., our last holiday), and imagine and plan for events that have not happened (e.g., our next job interview); that is, we can mentally travel back into our past (i.e., episodic memory) and our future (i.e., future thinking). Having a comprehensive picture of this capacity involves not only studying Mental Time Travel (MTT) in humans but also in non-human animals. Due to conceptual and methodological
limitations, the field of MTT is still in its infancy. Comparative and interdisciplinary studiesinvolving more than one animal species are needed to understand the evolution and development of this capacity. I aim to address this issue by developing two novel empirical approaches to test how non-human primates (chimpanzees), corvids (rooks) and human children use information about past events to think and imagine future events. The results of this research will provide crucial insights for theories of cognitive development (e.g., the relation between theory of mind, executive functioning and mental time travel) and human evolution (e.g., the role of mental time travel in humanitys ability to build upon knowledge or skills generation after generation). In this sense, broadening my theoretical background and acquiring new methodological skills (e.g., testing new animal species)as I plan to do during this fellowshipwill be of crucial importance for me to further develop my career.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 195271;656455;METENZ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;To develop a novel class of metalloenzymes for application in novel asymmetric C-H activation chemistry.;1/04/2015;31/03/2018;;Chemical synthesis through the activation of inert C-H bonds allows scientist to efficiently assemble complex organic molecules which have specific function. We aim to develop a novel class of metalloenzymes, where a transition metal catalyst is embedded into a genetically engineered protein, for rhodium catalysed asymmetric C-H activation reactions. We believe that the approach of incorporating a transition metal into a protein will allow for precise control of the chemical environment around the transition metal, allowing us to control many key outcomes of the chemical reaction such as enantioselectivity, regioselectivity and reaction rates. This technology will allow for the development of C-H activation reactions that have previously been inaccessible to the synthetic chemistry community.;251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195362;656943;AluminiumScrapDbase;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Aluminium Scrap: Open access database for impurity levels-microstructure-property and methods to recover properties in high impurity scrap;1/09/2015;31/08/2017;;"Aluminium (Al) alloys are extensively used in transport (28%), construction (35%) and engineering (27%) sectors. The total Al in use is expected to increase from 600 million tonnes in 2013 to one billion tonnes by 2020, thus creating a large metal bank for future recycling use. Currently primary Al production from bauxite ore is the primary source of Al metal supply to industry. Since primary aluminium production is an energy intensive process and the world's bauxite deposits are limited, the use of Al scrap accumulated from packaging, building, automotive and engineering sectors offers a sustainable solution to secure metal supply. However, the scrap from these sectors has higher levels impurities in particular with iron (Fe). Higher concentration of Fe is detrimental to the mechanical properties due to formation of harmful platelet structures of Fe-based intermetallics.

The overall aim for the fellowship is to develop solidification science based methods which enables the use of aluminium scrap alloys to produce high value aluminium products to support the rapid growth of Al. The objectives are (i) To develop methods to tolerate higher iron impurity concentrations in Al scrap alloys using model alloys containing impurities, through enhanced heterogeneous nucleation, intermetallic morphology control and restricting their growth (ii) to understand the solidification behaviour of scrap alloys by attempting to tackle the problem from thermodynamic analysis, engineering the microstructure through various approaches and an in-depth understanding of the behaviour of intermetallics using advanced tools, examine the effect of impurities on properties and to determine micro-mechanical properties of various synthetic iron based intermetallic phases, (iii) to build an open access database for impurity levels in scrap alloys-property-process dependence and to provide guidelines for Al component manufacturers on critical levels of impurities in specific alloys.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BRUNEL UNIVERSITY LONDON;UK;;; 195330;656812;Amine-FUNC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Amine-Directed Diverse C(sp3)-H Functionalization;1/04/2015;31/03/2017;;The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Although some progress have been achieved in this emerging area, the selective transformation of aliphatic C-H bonds is still a challenge. This proposal aims to develop a new platform for the direct activation of unactivated sp3 C-H bonds of aliphatic amines and to apply this novel C(sp3)-H functionalization technology to synthesize diverse amine compounds. A key novel concept of this project is to use an unprotected aliphatic secondary amine as a native directing group, through a remarkable 4-membered-ring cyclometallation pathway. The goals of this proposal include: (I) developing unprecedented diverse C(sp3)-H functionalization of amine technology, accessing diverse functionalized amine compounds, (II) developing novel Pd-catalyzed enantioselective C-H functionalization methods to make enantioenriched chiral molecules, (III) application of this novel C(sp3)-H functionalization technology to make a library of diverse functionalized Salbutamol and Bupropion analogues, and screen them for biological and medicinal activities.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195498;657725;APCINTERACTIONS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular basis for securin and cyclin ubiquitylation by the anaphase-promoting complex (APC/C);1/03/2016;28/02/2018;;"This research proposal describes an ambitious effort to characterize structurally and biochemically ubiquitin chain initiation and elongation by the anaphase-promoting complex or cyclosome (APC/C) in complex with two well-characterized substrates. The APC/C is a multi-subunit cullin-RING E3 ubiquitin ligase that controls progression through the cell cycle by a temporal regulation of its activity and substrate specificity. Regulation and specificity of this E3 ligase is achieved through mutually exclusive binding of two structurally related co-activator subunits termed Cdc20 and Cdh1, as well as through APC/C inhibitors, varying substrate affinities and auto-ubiquitylation of its cognate E2s, namely UbcH10 and Ube2S. In order to understand ubiquitin chain initiation and elongation of the two well-known APC/C substrates cyclin B and securin, I am aiming to use a combined approach of cryo-electron microscopy, X-ray crystallography and a variety of biochemical methods. Within this project I will use cryo-electron microscopy studies to uncover the molecular mechanisms of substrate recognition and ubiquitin chain initiation and elongation by analyzing the APC/CCdh1 co-activator complex bound to its transiently associated E2 enzymes Ube2S or UbcH10 and one of the aforementioned high affinity substrates.
Crystallization of selected sub-complexes, namely the catalytic core of the APC/C (composed of Apc2 and Apc11) is intended. If obtained, this high-resolution information will then assist the interpretation of the resulting density maps derived from cryo-electron microscopy.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 195178;655844;DEMONH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;DEsign of Multifunctional 2D-OrgaNic Hybrids;1/01/2016;31/12/2017;;"Because of their reduced dimensionality and symmetry, two-dimensional (2D) materials withstand physical phenomena that are very different from their 3D bulk counterparts. Beside graphene, other members of the same family of materials include metal dichalcogenides (MX2) and hexagonal boron nitride (h-BN). Remarkably, while single-layer graphene is a semimetal, 2D h-BN is an insulator and 2D MoS2 is a direct bandgap semiconductor. A new paradigm in materials science consists in piling up into vertical stacks single sheets of 2D materials with complementary electro-optical characteristics, thereby paving the way to the fabrication of ultrathin and flexible multilayer heterostructure devices. DEMONH aims at designing multilayer architectures based on 2D material building blocks with tunable electronic structure and optical properties that can be prepared by solution processing techniques. Among many others, this approach offers the unique advantage that the electrical and optical characteristics of the elementary 2D units can be tuned over a broad range by functionalization of their surface with properly designed conjugated organic molecules, which: (i) assist in the exfoliation process and stabilize single or multiple layers as suspensions in the liquid phase; and (ii) convey to the resulting hybrid organic-2D materials new or improved functionalities. In particular, the use of light-responsive molecules opens up the possibility to remotely switch on and off charge injection and extraction at interfaces. In DEMONH, we will combine state of the art modeling tools to design multifunctional electro-active conjugated molecules yielding optimized (light-triggered) energy level alignment at interfaces and charge transport properties in stacked 2D layer architectures. Such design strategies require the development of appropriate theoretical models and their coding in efficient software programs, which will be implemented in a multiscale modeling platform.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE MONS;BE;;; 195222;656208;NEXTNANOCELLS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Next generation nanowire solar cells;1/08/2015;31/07/2017;;"Nanowire solar cells are an innovative and promising way to further reduce the cost of photovoltaic electricity for terrestrial applications. Accordingly, the ultimately goal of this project is to develop a multi-junction solar cell composed of an array of III-V nanowire subcells, electrically connected to a state-of-the-art Si solar cell. In order to do so, two different epitaxial techniques will be used to accomplish the epitaxial growth of the nanowires: standard MOVPE growth and the ground-breaking technology of Aerotaxy. Then, the nanowires will be embedded in a polymer and transferred to a Si substrate.

The project will be undertaken at Lund University, a world renowned and leading research center in nanoscience and nanotechnology. The project includes not only the development of cutting-edge nanotechnology applied to photovoltaics, but also a comprehensive training program in transferable skills. A secondment in Sol Voltaics AB is also scheduled to assure the inter-sectoral transfer of knowledge, which in turn contributes to the establishment of a knowledge-based European economy. Therefore, the project represents in several ways a valuable opportunity to the researcher and to Lund University.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LUNDS UNIVERSITET;SE;;; 195281;656514;GENEVABREED;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Cloning and functional characterization of a complex resistance locus from Geneva to breed apple cultivars with durable scab resistance;1/11/2016;31/10/2019;;"Apple scab caused by Venturia inaequalis is the major constraint to apple production worldwide, causing severe economic losses. As current commercial cultivars are highly susceptible to scab, introduction of new scab-resistant cultivars will reduce the intensive use of pesticides now required to control this disease. Although the Geneva apple is an important source of resistance for breeding, its complex scab resistance has not been properly characterized. In preliminary studies, we mapped to chromosome 4 of Geneva a 5 cM region containing three genes conferring both dominant and recessive scab resistance, which corresponds to a 2 Mbp region containing nine candidate NBS-LRR resistance genes on the physical map of Golden Delicious (GD). This provided the first evidence of recessive genetic control of apple scab resistance. In this project proposal, we will further characterize this complex locus, employing next generation sequencing, together with bioinformatics and functional analysis of disease candidate resistance genes (CRGs): (1) we will sequence the resistance locus in Geneva and identify CRGs that are polymorphic (presence/absence, or sequence polymorphism) between the resistant Geneva and the susceptible GD; (2) we will clone each CRG with its native promoter, terminator and introns; and (3) transform susceptible lines with the individual CRGs to evaluate their effect on the level of disease resistance and its race-specific spectrum. This will not only build a better understanding of the genetic basis of apple scab resistance and the gene-for-gene relationships between the pathogen and the host, but it will enable the development of molecular markers for breeding new sprayfree cultivars with durable scab resistance.";238354,2;238354,2;H2020-MSCA-IF-2014;MSCA-IF-GF;FONDAZIONE EDMUND MACH;IT;;; 195230;656122;CLIMAPROX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hunter-Gatherer adaptations in northern Iberian Refugia from the Last Glacial Maximum to the Mesolithic: a multi-proxy climatic investigation.;1/04/2015;31/03/2017;;CLIMPROX uses a ground breaking multi-proxy methodology integrating isotopic analysis of ungulates and archaeozooological reappraisal with a additional climatic proxies (pollen, sediments, anthracology, and microfauna) to understand human responses to palaeoenvironmental change over 21 to 7 uncal. ka BP, a crucial period in human evolution. CLIMAPROX explores the role of the environment and climate in the migration of people into the refugia of the Cantabrian region, the flourishing of Upper Palaeolithic societies, and in the subsequent dietary diversification at the end of the Last Glacial period that lay the foundation for the origins of farming in Europe. The multiple scientific datasets, regional and temporal scale of the analysis make CLIMAPROX highly innovative, acting as a case method for future research investigating human-environment interactions across the globe. This project will therefore have a high scientific impact not only in Iberian archaeology, but within the field of European Palaeolithic research, and bioarchaeological, contributing to pertinent discourse into human-environment interactions.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE CANTABRIA;ES;;; 195339;656842;HspAdhesion;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role of cell membrane associated Hsp70 in cancer cell adhesion and metastasis;1/05/2015;30/04/2017;;We propose an interdisciplinary project at the interface of biophysics, biochemistry, and medical research. Our objective is to investigate the specific role of cell membrane associated heat shock protein 70 (Hsp70) in the context of invasive cancer. In particular we address the question how cell membrane localization of Hsp70 affects differential adhesion of cancer cells and the formation of metastasis. In general, heat shock proteins (HSP) assist in folding of nascent proteins, prevent protein aggregation, and assist transport of proteins. Upon a variety of stresses HSP production is rapidly upregulated. Hsp70 is the major stress-inducible member of the HSP70 family. In normal cells it copes with harmful unfolded and denatured protein conferring protection to the cell. Tumor cells frequently present Hsp70 on their outer surface where it exhibits additional activities. For a number of different tumors a high level of membrane Hsp70 has been found to indicate drastically decreased survival chances in patients. Moreover it has been implicated in formation of metastasis where it might support spread and anchoring into distant tissues. These findings highlight the clinical significance of cell membrane associated Hsp70 and the need for a better understanding of its role in differential cell adhesion and progression of cancer. We will employ atomic force microscopy (AFM) in order to elucidate the function of membrane Hsp70 as a possible adhesion molecule or mediator of cellular adhesion. (1) Using single-cell force spectroscopy we will characterize and quantify adhesion forces of Hsp70 positive and negative cells to different substrates mimicking their interaction with extracellular matrix and host tissue. (2) With the help of a specialized AFM technique that enables topography imaging with a simultaneous recognition of specific surface molecules we will determine the localization and arrangement of Hsp70 molecules on the cell surface with nanometer resolution.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT LINZ;AT;;; 195246;656318;MoTOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Analysis of the moonlighting proteins in the mTOR-signalling pathway;1/02/2016;31/01/2018;;The mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase in eukaryotic organisms. mTOR is the catalytic subunit of two different complexes (mTORC1 and mTORC2), which differ by their subcellular localization and function. The mTORCs integrate the environmental and cellular signal and regulate a broad range of downstream growth events. Impaired regulation of mTOR was often observed in tumors, Alzheimers disease, several metabolic disorders, and is known to accelerate aging. Thus, the study of the mTOR pathway is of paramount importance for both fundamental biology and medicine. A tremendous amount of studies have been carried out to elucidate the regulatory role of mTOR in metabolism and diseases. Yet the detailed mechanism of the mTOR regulatory pathway remains to be completed. Recently, using the novel method mRNA interactome capture, the host laboratory identified proteins involved in the mTOR-signalling pathway that acts as RNA-binding proteins (RBPs) in yeast, mouse embryonic stem cells (mESC) and HeLa cells. This finding revealed a conserved and previously unrecognized function of the mTOR pathway with RNA being an important component of it. Here I propose a project aiming to unravel the biological function of RNAs and RBPs in the mTOR pathway. In this project, I will use the budding yeast Saccharomyces cerevisiae as a model system, and will identify the novel RNA binding domains (RBDs) of the RBPs. I will further investigate the network of the interacting RBPs and RNAs. This will elucidate the biological impact of the RNA-protein interactions in the mTOR pathway. I will carry out this interdisciplinary study using biochemical and genetic methods, as well as large-scale analysis. The datasets created in this study will open new perspectives on the mTOR regulatory pathway.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;;; 195254;656349;IPBMNES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Integrated Pedestrian Behavior Modeling under Normal and Evacuation Situations;1/01/2017;31/12/2018;;In order to understand the nature of complex and collective dynamics of pedestrians during normal and evacuation situations, mathematical models and simulation tools are essential. Compared to vehicular flows, pedestrian movements show a more complex behavior, mainly because they are essentially two-dimensional and not limited to specific lanes. Moreover, in pedestrian dynamics, collective dynamics will be formed from individual human nonlinear interactions. Specifically, pedestrian behavior is the result of a series of interdependent decisions which are based on a specific plan. The plan is a latent (unobserved) variable resulting in a series of (observed) actions. However, in state-of-the-art pedestrian flow models, the latent plans and some observed actions are ignored. When it is implemented in simulation software, this leads to an unrealistic representation of individual pedestrian movements and collective crowd dynamics. In order to overcome this issue, a framework for integrated pedestrian behavior modeling based on the concepts of a short-term plan and action, is proposed. This framework integrates the following sub-models: Target Destination Choice Model, Pedestrian Route Choice Model, Pedestrian Pace State Model, and a Pedestrian Movement Model. It captures pedestrians' planning capabilities and interdependent decisions. The parameters of all the components of the framework are estimated jointly by observed pedestrian trajectories using maximum-likelihood theory. Finally, the above behavioral models will be incorporated in the traffic simulator, MovSim (Multi-model open-source vehicular-traffic Simulator developed by Technical University Dresden -TUD) to simulate the normal and evacuation pedestrian environment. This tool will be useful to develop guidelines for local authorities and organizers of mass events in larger cities of Europe and for designing the pedestrian facilities.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET DRESDEN;DE;;; 195229;656195;ION-QNET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cavity-QED Ion Quantum Network;1/05/2015;30/04/2017;;"Trapped ions are promising candidates as qubits. However, their scalability for quantum information processing (QIP) remains challenging. A route to address this issue relies on quantum networks (QN), in which material qubits held at separate locations (nodes) exchange quantum information via photons. The QN architecture can also be used to transfer quantum information over long distances, and as the basis for a quantum simulator.
We propose to realize a two-node QN based on ions and cavity quantum electrodynamics. At each node, photons and ions interact via a high finesse cavity, allowing coherent transfer of information. Our QN will consist of two nodes separated by 8 meters and connected by a 15 meter long optical fiber. A first node is already built and working, based on a cavity operating in the intermediate coupling regime. The second node is under development and should reach the strong coupling regime, which has not yet been observed with a single ion. Our approach relies on a high-finesse cavity with a small mode volume, defined by the shaped and coated facets of two optical fibers. This fiber cavity is integrated with a miniaturized linear ion trap.
The fellow will first develop and optimize the fiber-cavity setup to demonstrate the strong coupling regime. Then he will implement at this node a toolbox of quantum communication protocols. Finally he will interconnect both nodes and test the resulting QN with fundamental protocols: entanglement of two distant ions heralded by the detection of photons, and transfer of a quantum state from one ion to the other. Such a proof-of-principle ion-based QN represents a building block for more complex architectures, reinforcing and securing the European Unions leadership in strategic research areas like QIP, quantum communication, quantum simulation and metrology.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET INNSBRUCK;AT;;; 195175;655817;Cdc42Adhere;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role of Cdc42 in cancer cell adhesion to endothelial cells and platelets;11/05/2015;10/05/2017;;"Metastasis accounts for 90% of cancer deaths, and it is therefore important and timely to identify new therapeutic targets aimed specifically at metastasis. Cdc42 has recently been implicated in a key step of the metastatic cascade: the extravasation of circulating tumour cells, also termed transendothelial migration (TEM) . This project aims to study how Cdc42 contributes to breast cancer cell TEM in vitro and in vivo. Cdc42 regulates ?1?integrin expression via the transcription factor serum response factor (SRF) and thereby stimulates cancer cell adhesion to endothelial cells (ECs) and TEM. To analyse the molecular basis for this regulation, downstream targets of Cdc42 will be depleted by RNAi in a panel of breast cancer cells to determine which target/s are responsible for altering ?1?integrin expression, adhesion to ECs or TEM.
Cancer cells interact with platelets as soon as they enter the bloodstream, and this enhances cancer cell TEM in vivo. It is therefore possible that Cdc42 regulates attachment to platelets as well as ECs. The role of Cdc42 in the interaction between platelets and cancer cells will be tested by adding purified platelets to control or Cdc42?depleted breast cancer cells in vitro and analysing platelet aggregation around cancer cells by confocal microscopy. The role of Cdc42 in platelet attachment to cancer cells during early lung colonization in vivo will be studied by intravenous injection of fluorescently tagged breast cancer cells in mice.
This project will increase our understanding of metastasis. The identification of molecular targets involved in cancer cell extravasation will provide a starting point for the development of new drugs, thus contributing to reduce the mortality of patients with metastasis.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195256;656357;RAGES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular determination of Rif1-Associated Genomic Elements and their function in regulating genome activity and integrity;31/03/2016;30/03/2018;;DNA double-strand breaks (DSBs) are highly toxic and must usually be accurately repaired to prevent oncogenic mutations. However, DSBs also represent necessary intermediates of recombination events required to create genetic diversity in immune repertoires and the germline. These distinct cellular contexts require that DSBs are differentially metabolised to achieve the required genetic outcome. Thus a complex system has evolved to regulate DSB repair. Rif1 was recently identified as a critical regulator of DSB repair, recruited to chromatin at DSBs by the 53BP1 chromatin reader. However, little is known about how these proteins cooperate to alter the chromatin landscape at DNA damage sites, and how this influences DNA repair decisions. Understanding the molecular basis of these proteins function is paramount, as misregulation at the level of Rif1/53BP1 is known to drive disease: loss of either protein results in primary immunodeficiency, while an inability to counteract Rif1/53BP1-dependent activities during DNA repair is associated with genomic instability that drives carcinogenesis. Interestingly, recent evidence suggests that Rif1 may also mediate gene-repression in certain chromatin contexts. This raises the possibility that the manner by which Rif1 regulates transcriptional control may be similar to its role in DNA repair. In this proposal, I seek to test my hypothesis that Rif1 mediates repressive chromatin states to regulate both transcription and DNA repair outcomes. My preliminary work and an array of unique cell lines and molecular reagents developed by my host laboratory, provide me with a unique and timely opportunity to examine this fascinating protein, and develop a better understanding of potentially common regulatory mechanisms that govern transcription and DNA repair.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195292;656596;SilhouetteOfSeaweed;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Overcoming barriers in estimating toxicity of arsenic species in seaweed;1/04/2015;31/03/2017;;SilhouetteOfSeaweed will contribute to consumers safety by overcoming barriers in estimating toxicity of arsenic species in seaweed. The ocean covers 71% of the planet and for future sustainability the need for looking at using the ocean for food, e.g. seaweed, is increasing. Seaweed contains high amounts of arsenic, including arsenolipids (AsLp). Recently the first data on AsLp toxicity have elucidated that they are as toxic as the most toxic arsenic, the inorganic arsenic (iAs). There is a lack of data on AsLps in seaweed products for human consumption. Safety of seaweed must be addressed and more studies and information on AsLps are urgently needed. Currently, only few research groups worldwide work on AsLps, partly due to difficulties associated with the measurements of these compounds. SilhouetteOfSeaweed will expand this expertise in Europe by establishing necessary facilities at the host Mats to accommodate AsLp measurements. Mats has the capacity to reach this goal together with the experienced researcher and in co-operation with a European partner organisation with expertise in AsLp measurements. SilhouetteOfSeaweed will have two main scientific impacts. Firstly, it will produce AsLp seaweed profiles in 4 different species of brown algae in 3 locations during 3 seasons in Iceland. This information will contribute to the necessary risk assessment needed for algae used for human consumption. Secondly, statistical evaluation and comparison of environmental conditions will make it possible to identify whether the seaweed could be harvested at specific conditions where the amount of toxic arsenic is at its lowest. These data are essential for SMEs entering the European market with their seaweed products. Moreover the project will impact the career development of the experienced researcher who will gain a wide range of scientific and transferable skills that are relevant to establish a long-term independent leading career in the field of science.;191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MATIS OHF;IS;;; 195483;657650;DLCHHB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Artificial Tissue Actuators by the 3D Printing of Responsive Hydrogels;1/07/2015;31/12/2017;;"This proposal describes the 3D printing of hydrogel droplet networks to prepare artificial tissue-like materials that demonstrate stimulus-responsive chemo-mechanical actuation. A recent breakthrough by Prof. Bayleys research group has enabled the 3D printing of self-supporting droplet networks which can be functionalised to allow rapid electrical and molecular communication along a specific path. As a result of this, an opportunity now exists to prepare tissue-like materials that can perform mechanical work in response to external stimuli. By printing biocompatible and responsive polymer hydrogels into droplet networks, artificial muscles will be prepared that display specific and well-defined motion. The resulting technology will be of great importance for a variety of biomaterial applications, with future European Union (EU) industrial growth as well as the public ultimately benefiting from progress in this area.

This proposal is inherently multi- and interdisciplinary, involving aspects of synthetic chemistry, polymer chemistry, materials science, chemical biology and biophysics. The different expertise of Prof. Hawker, University of California, Santa Barbara (hydrogels, responsive polymers and biocompatible materials), and Prof. Bayley, University of Oxford (3D printing of artificial tissue, lipid bilayers and membrane proteins), are ideally suited for the successful completion of the proposed research objectives. Due to his prior experience and track record, the experienced researcher, Dr. Lunn, will be able to effectively drive the progression and dissemination of the proposed research. Ultimately, this project will allow one of the United Kingdom's top young researchers to spend time at one of the highest ranked materials research institutes in the world, and transfer the knowledge back to the EU via the University of Oxford. After the fellowship, Dr. Lunn will use the knowledge and skills acquired to obtain an independent academic position within the EU.";226825,2;226825,2;H2020-MSCA-IF-2014;MSCA-IF-GF;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195443;657425;TRANSFORMER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transformation of emerging contaminants in the aquatic environment. Fate of transformation products under multiple stress conditions;11/05/2015;10/08/2016;;"Pharmaceutically active compounds (PhACs) are a special class of contaminants because they can undergo transformations through metabolism before their entrance into aquatic and terrestrial environments. Once they reach the environment they are further transformed by abiotic and/or biotic transformation processes and understanding of transformation pathways and identification of transformation products (TP) is a prerequisite for a thorough assessment of their environmental risk. This project proposes the use of Experimental Stream Facility (artificial rivers), a unique facility available at ICRA that will permit simultaneous study of biodegradation, photolysis, and adsorption /desorption processes under different situations, such as intermittent flow (drought), temperature or light fluctuations, among others. State of the art hybrid and high resolution mass spectrometric instrumentation will be used to study transformation pathways and provide a comprehensive and detailed profile of TPs formed. By using an integrated approach and simultaneous study of biotic and abiotic transformation processes TRANSFORMERs main expected results are: (i) elucidation of transformation pathways (biological and photo induced) and identification of main TPs from a number of relevant pharmaceuticals (including some understudied and, for the first time, a new class pharmaceuticals such as peptidomimetics and peptide therapeutics); (ii) determination of partition coefficients (water-sediment and water-biofilm) of the studied pharmaceuticals and TPs and (iii) identification of potential controlling factors and mechanisms behind in-stream attenuation of pharmaceuticals (biodegradation vs photodegradation vs sorption). Accordingly, we expect that the results produced by this innovative research plan will have substantial impact on the field of inland water research, one of the Europes Societal Challenges.";106326;106326;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT CATALA DE RECERCA DE L'AIGUA;ES;;; 195266;656439;ESAIRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Engaging Citizens in Science: Promoting the Viability of Participatory Sensing for Monitoring Air and Environmental Quality;1/04/2015;31/03/2017;;"Participatory sensing initiatives for monitoring air and environmental quality are flourishing as a result of the citizens growing concern about pollution. Scientific teams and Do it Yourself communities are developing personal sensor kits and data aggregation platforms, leveraging smartphones to gather environmental data. However, the human and social aspects that have the power to sustain these citizen science projects do not receive enough attention.
ESAIRE aims at addressing the citizen engagement challenges that affect the viability and impact of citizen science and participatory sensing projects. In collaboration with the Air Pollution program of CREAL and the UCLs Extreme Citizen Science research group, the researcher will apply a novel human-centered approach to participatory sensing, based on a case study in Barcelona. ESAIRE is a multidisciplinary project lying at the intersection of Society and technological systems, with applications in public health and environmental research and potential to impact policy decisions.
First, ESAIRE will develop a public engagement strategy and media dissemination plan to involve citizens and local authorities in a participatory sensing project from the early stages of design. Secondly, ESAIRE will explore innovative methodologies to incorporate citizens contributions into the design of participatory sensing: from novel visualization solutions to community building strategies, and the creation of communication channels with the authorities. Finally, ESAIRE will contribute to advancing the state-of-the-art in participatory sensing with a conceptual framework of citizen science, human-centered methodological guidelines, and evaluation measures to assess impact.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA;ES;;; 195315;656741;ALGOVIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Algorithmic Approaches to Spatially-Informed Information Visualization;1/09/2015;31/10/2016;;"We propose a fellowship that will propel an outstanding young researcher and provide him with the skills, experiences and contacts that will enable him to develop into a key contributor to international and interdisciplinary research in an important emerging field that has wide application in commerce, government and industry.
Computational Geometry is largely theoretical whilst Information Visualization is broadly applied. The proposal focuses on a talented computational geometer, who has already begun working with colleagues and commercial organizations across the world to develop his research in an applied context with some success. It embeds him in a renowned Information Visualization group at CITY University Londonan institution that is uniquely positioned both academically and geographically, with its portfolio of professional education and proximity to one of the worlds leading centres of technology-fuelled creative industry. The fellowship will provide access to academic expertise in a complimentary discipline, experience and training in research and entrepreneurship, and close collaboration with partners in industry and government.
This interdisciplinary research and training will equip an experienced researcher with the skills, experience and contacts to move an important applied discipline forward in the future. With a programme that draws upon formal provisions within CITY and takes advantage of existing contacts with partners in London from the commercial sector, the fellowship will: (1) add algorithmic rigour to Information Visualization design; (2) inform algorithmic design through access to other disciplines and practitioners; (3) provide the researcher with experience of new fields and practices; (4) bring two complimentary fields together and change disciplinary mindsets; (5) develop the researcher through experience and training in research, teaching and entrepreneurship and by developing his international network across disciplines and sectors.";107015,3;107015,3;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CITY UNIVERSITY OF LONDON;UK;;; 195347;656878;SO-CMA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Improving the safety of oral immunotherapy for cow's milk allergy in children;7/03/2016;6/03/2018;;"Background: Food allergy affects 6% of children in the EU, and has a major impact on quality of life, nutrition, health-economics and the food production industry. Cows milk (CM) is a common cause, and can be particularly problematic due to the ubiquitous nature of CM in foods. Strict dietary avoidance is difficult to achieve, and unpredictable life-threatening accidental reactions are common, leading to anxiety and social restrictions for patients and families. Oral immunotherapy (OIT) has been shown to be efficacious but is not widely accepted as routine treatment, due to significant safety concerns allergic reactions are common, and can be particularly severe in CM-OIT.
Objective: To improve the safety of OIT for CM allergy.
Proposed methods: WP1 - Systematic review of the literature to identify features of published OIT protocols that are associated with improved safety. WP2 - Assessment of human immune responses to candidate modified CM proteins (proven to be both non-allergenic and tolerising in murine models) as potential tools for immunotherapy. WP3. Phase 2/3 clinical trial to assess whether a sublingual pre-treatment phase can improve the safety of OIT in CM allergic children.
Deliverables: 1) Systematic review to identify features of CM-OIT associated with improved safety. 2) Evidence on the immunogenicity of candidate modified CM proteins in humans, which will reflect their suitability as immunotherapy agents in the future. 3) Data relating to whether an initial sublingual phase can improve the safety of CM-OIT. 4) Pilot data on mechanisms underlying the immune-modulation induced by OIT. 5) Skills transference to the applicant to become a highly qualified independent researcher, with expertise in OIT for food allergy at an International level. 6) Consolidation of the host institution as a centre of excellence in food immunotherapy, including the potential for tolerising modified proteins to improve OIT safety and efficacy.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195324;656779;MOPIGRASFIT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Motion Picture Grammatical Rating System for Infants and Toddlers;1/07/2015;31/05/2017;;"'The use of infant-directed media has increased substantially, from 17% in the 1990s to now over 50% in the first year of life although this use is highly controversial. Current motion picture rating systems in Europe only target viewers above 3 years, and only in terms of content. Infant-directed videos include a wide range of cinematic techniques which require film literacy to understand. It is therefore crucial to investigate comprehensively the role of such techniques on infant attention so as to ascertain the impact videos may have on the developing brain. The overall objective of the proposed research is to assess systematically the role of: (a) cinematic techniques, (b) viewing experience and (c) cognitive development on the comprehension of moving images and, on the basis of the findings, (d) to suggest an 'age-appropriateness' rating scheme for infants and toddlers (e.g. 12m\, 24m\) for audiovisual material. Six-, 12-, 18-, 24- and 36-month-old young children will be categorized into two groups according to the extent of their viewing experience and tested in a cross-sectional study, the findings of which will have important implications for childrens mental development by identifying the age-appropriate cinematic techniques for comprehension of moving images, which may be suitable educational media for infants. This proposal falls squarely within the topics emphasized in the EU 7th Framework socio-economic sciences and humanities themes; it is multidisciplinary, combining film studies, vision sciences, cognitive psychology, developmental psychology, and developmental neuroscience, and will yield significant contributions to the film, TV and educational technology fields within the European Research Area.'";187310,85;187310,85;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BIRKBECK COLLEGE - UNIVERSITY OF LONDON;UK;;; 195216;656144;RADIOGENFF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;RADIOGENOMICS: Finding Genetic Functional Variants Through Fine Mapping;1/04/2016;31/03/2018;;"Radiogenomics is the study of the genetics of toxicity following radiotherapy. Unintended damage to normal tissues can severely affect up to 5% of patients for years after completion of curative cancer radiotherapy. To date three Genome Wide Association Studies on radiation toxicity in prostate cancer patients have been performed. These studies have identified genetic loci associated with development of radiation-induced toxicity phenotypes in local tissues. To increase the very limited power of each independent study, the three groups are collaborating on a meta-analysis of harmonised toxicity phenotypes (nocturia, urinary frequency, decreased stream and proctitis) and have identified several promising new loci. The proposed activity at the Centre for Cancer Genetic Epidemiology will be fine-scale mapping of these loci identified with the aim of identifying the genetic variants directly responsible for these toxicity phenotypes. The objectives of the proposed research are: 1. For the Researcher to learn advanced genetic epidemiological and fine-mapping skills by participating in team-based analysis of incoming massive, OncoArray datasets which will be analysed at the host institution; 2. Identify and validate additional novel genetic radiation toxicity loci through analysis of specific radiotoxicity SNP-sets on the Oncoarray and through additional GWAS meta-analysis; 3. Apply high-level skills, gained in objective 1, to the fine scale mapping of radiation toxicity loci with the aim of to identifying the top genetic causal candidate variants for radiation toxicity; 4. Carry out bioinformatic functional analysis of the top causal candidates to both narrow the candidate list further, and gain understanding of the molecular patho-physiology and genetic mechanisms that mediate the development of radiation-induced toxicity. Knowledge of these will constitute a further step in identifying genetically at-risk groups likely to benefit from personalized radiotherapy.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195160;655723;OHPF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Optimizing for Happiness in Personal Finance;30/09/2015;29/09/2017;;"In this project, we will (1) investigate the ability to use the log of emotional states captured with wearable trackers for improving affective forecasting abilities of people, (2) build a tool for managing personal finance that integrates prediction analytics, and (3) evaluate if accurate expectations about purchases increase happiness of individuals.

Happiness and wealth are important metrics in our society with no simple relationship between them. One explanation for why money does not buy happiness is that individuals often have imprecise expectations about things they buy: imprecise forecasting of the nature, intensity and duration of an affective response derived from a purchase. Current technology enables people to track how money is spent to help take control of ones personal finance, balancing income and expenses, and achieving financial goals. A similar trend is present in tracking of emotional well-being of people through novel wearable sensors emerging from the Quantified Self movement. This project harnesses these unique and timely developments in improving the positive impact wealth can have on happiness. We will improve the accuracy of affective forecasts about future purchases by keeping history of emotional states and associated spending, performing prediction analytics based on the collected data, and providing feedback about anticipated affective value of the purchases. Such a feedback is expected to remedy the biases in affective forecasting that people are prone to and can be integrated into the tools for managing personal finance.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195231;656214;2DInterFOX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Integration of two-dimensional nanomaterials with functional oxide nanostructures;1/06/2015;31/05/2017;;The integration of two-dimensional (2D) nanomaterials with non-2D nanostructures is of key technological importance in nanoelectronics and energy applications. Despite this, the atomistic understanding of 2D/non-2D interfacing is critically limited. In particular, functional non-2D metal-oxides need to seamlessly integrate with 2D materials (as e.g. dielectrics, barrier layers, charge transfer dopants or photo-catalysts) but to date 2D/non-2D oxide interfacing has not been addressed on an atomically resolved level. The project proposed here employs atomically-resolved, element-specific, aberration-corrected in-situ scanning transmission electron microscopy (STEM) techniques to elucidate the structural, chemical and electronic interactions of scalably chemical vapour deposited 2D nanomaterials (graphene, hexagonal boron nitride, molybdenum disulphide) with device-relevant non-2D metal-oxide nanostructures (e.g. Al2O3, HfO2, MoO3, TiO2). The project links realistic ex-situ 2D/non-2D oxide integration processes (evaporation, sputtering, atomic layer deposition) with dedicated in-situ STEM experiments and complementary spectroscopic fingerprinting (electron energy loss spectroscopy, x-ray photoelectron spectroscopy). It benefits from a unique combination of the applicant researchers extensive experience in in-situ characterisation of 2D materials and the applicant supervisors pioneering track record in STEM of 2D materials. The proposed work will establish a holistic picture of 2D/non-2D oxide interactions and thus provide critically required insights towards industrially scalable integration of 2D nanomaterials with non-2D nanostructures.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195300;656644;INSCAPE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography;15/05/2015;14/05/2018;;Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare due to common off-target effects. Therefore, new NaV-blockers will be developed and used for in vivo imaging using positron emission tomography (PET). For this purpose, novel derivatives of the recently disclosed truncated batrachotoxin (tr-BTX), which represent a completely new type of NaV-blockers, will be synthesized and their ability to block different NaV isoforms (NaV1.1 to 1.8) will be tested using fluorescent assays. The most promising candidates will then be labeled using different positron emitting isotopes such as carbon-11 (11C) and fluorine-18 (18F) exploiting different radioactive half-lifes and metabolic stability. The resulting hot-tr-BTX will be subsequently employed in small rodent PET-scans revealing their in vivo pharmacokinetics. This novel and unique tool will provide three major immediate benefits. First, hot-tr-BTX might deliver a general imaging probe for nervous activity in the PNS, and potentially the CNS, by monitoring NaV function in vivo. Secondly, this will allow the investigation of various pain conditions and neurodegenerative diseases and link their pathogenesis to NaV-function. Thirdly, the proposed research might deliver not only new NaV-blockers as potential drug candidates, but will also provide a valuable method facilitating the development of long awaited drugs targeting NaVs for pain therapy, a goal that is currently intensely investigated by numerous European and global pharmaceutical companies.;239860,8;239860,8;H2020-MSCA-IF-2014;MSCA-IF-GF;KLINIKUM DER UNIVERSITAET ZU KOELN;DE;;; 195145;655645;SAPFLUXNET;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards a global database of sap flow measurements to unravel the ecological drivers of transpiration in woody plants;1/01/2016;;;Plant transpiration is one of the main components of the global water cycle, and at the same time, water availability is one of the main abiotic factors limiting plant productivity, growth and survival. Hence, understanding the main environmental controls on tree water use is essential to address relevant questions posed by global change-related impacts on forest ecosystem services, including water availability and carbon sequestration. Sap flow measurements using thermal methods have now been applied to measure seasonal patterns in water use and the response of transpiration to environmental drivers across hundreds of species of woody plants worldwide, covering a wide range of climates, soils and stand structural characteristics. Here, we will design and begin to assemble a global database of sub-daily, tree-level sap flow (SAPFLUXNET) that will be used to improve our understanding of physiological and structural determinants of plant transpiration and to further investigate the role of vegetation in controlling global water balance. I will collectively analyse sap flow responses to environmental drivers, at time scales from daily to seasonal and annual, using statistical and mechanistic models of plant water transport. I will synthesise the database into a set of traits related to physiological regulation of transpiration. I will analyse these traits in their climatic and phylogenetic context and in relation to other drought tolerance traits. SAPFLUXNET is the first project designed towards a profound understanding of whole-plant transpiration regulation in woody species across the globe.;172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT GENT;BE;;; 195277;656490;MagProtoCell;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Magnetic micromachines based on protocell design and engineering;1/05/2015;30/04/2017;;Protocells are artificial cellular systems exhibiting lifelike properties, which are proposed as a stepping-stone for understanding the origin of life on Earth. Features such as encapsulation, replication, metabolism and selective exchange of chemicals with the environment will enable their use as micromachines in a number of emerging applications (e.g., environment clean-up, clinical diagnosis, drug delivery, remote sensing, bioreactor technology). However, progress in such applications will be enhanced by the synthetic construction of protocells capable of directed movement in fluidic environments in response to external stimuli. To date, motility has been achieved only in a few cases, which involve a response to changes in chemical concentrations (chemotaxis) in the surrounding medium. However, controlling the chemical composition of the local environment is challenging, and thus alternative ways to stimulate motility are needed. In this regard, external magnetic fields (MFs) will enable high levels of control of protocell motility and spatial disposition to be achieved by employing noncontact forces. This is the aim of this proposal: to design and construct synthetic protocells able to sense and respond to external MFs. A key outcome of the work will be the development of a new class of magnetic micromachines based on protocell design and engineering. Such machines will couple MF-directed motility with the temporal and spatial delivery of advanced biomimetic functions. The key factor of the proposed methodology is the inclusion of colloidal magnetic particles at strategic locations in the protocell composition or in the external medium. Thereby, the expertise of the applicant (Dr. Rodrguez Arco) in the field of MF-responsive materials will be applied to the multidisciplinary and cutting-edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof. Mann FRS) has made great progress in the last few years.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195215;656203;EUROLIFE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Life histories of the Neolithic Transition: Estimating and modelling European life history events and human fertility rates;1/12/2015;30/11/2017;;"The EUROLIFE project will develop and test an advanced microscopic method for establishing human fertility rates in Europe over the period of the postulated Neolithic Demographic Transition (NDT) c. 7000-4000 BC. Dental histological evidence taken from radiocarbon dated archaeological assemblages will be used to accurately estimate variation in female fertility rates across the NDT and clarify the precise origins, shape, and structure of the associated rapid European population growth. This work will simultaneously provide paleodemographic profiles for the archaeological samples studied, allowing reconstruction of ageing profiles and other life history events with a direct histological analytical method. For the first time an explanatory hypothesis for the NDT that predicts increased female fertility will be rigorously tested at both local and regional European scales with direct evidence from individuals life histories.
This project will improve the Tooth Cementum Annulation (TCA) method to identify numbers of pregnancy/fertility events and to distinguish them from other life-history events. A clinical study on a large data set of human teeth (n. 200) with documented life-history information will enable rigorous archaeological protocols to be constructed. These protocols will be used to estimate fertility rates, life-history parameters, and aging profiles in a chronologically linked series of extant Mesolithic/Neolithic European skeletal collections in Europe. As multiple radiocarbon dates already exist for the proposed ancient samples and archaeological contexts, extant dates will be used to create preliminary Bayesian time-series models.
In summary, the EUROLIFE project will develop and test a highly innovative analytical technique to establish fertility rates, life history events and ageing profiles within the context of their larger populations through time. It will also provide a robust clinically supported protocol for future demographic research.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195214;656127;3F-FutureFreshFruit;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Elucidating the molecular basis of fruit resistance to desiccation: The cuticle as a key factor;15/09/2015;14/09/2018;;Water stress is a key environmental factor that causes important quality and economical losses before and after fruit harvest. As water depletion is becoming increasingly problematic, improving water efficiency and tolerance of plants to dehydration is a priority of the European Union, as reflected in the societal challenge of Climate action, environment and resource efficiency. Likewise, food waste reduction is another key issue in the framework of Horizon 2020, as described in Food security and sustainable agriculture and forestry challenge. Indeed, a large proportion of fresh produce is wasted during postharvest (25-50%) of horticultural crops, which is largely caused by dehydration. Therefore, this project deals with the urgent need of understanding factors influencing water loss to develop innovative solutions geared to saving water and reducing food waste. Based on the idea that cuticular waxes are critical for limiting water loss from fruit, and thus for resisting desiccation and spoilage, we propose to uncover the structural and regulatory pathways that mediate its biosynthesis, transport and assembly in response to drought stress through a multidisciplinary approach. Thus, SEM and TEM microscopy, GC/MS, as well as up-to-date technologies, such as Laser Capture Microdissection (LCM) and RNA sequencing, will be used. Tomato and citrus fruit will be selected as model systems to address this poorly understood area of plant biochemistry, physiology and molecular biology. The availability of mutants of both fruits, as well as the application of stress-related hormones during postharvest, will allow comparative surveys to better understand the regulation of these processes. The outcomes of this proposal will represent a major advance in the understanding of the crosslink between water stress, wax metabolism and fruit biology, and will suggest strategies for enhancing shelf life, drought hardiness and fruit quality in both climacteric and non-climacteric fruit.;239191,2;239191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195241;656285;DEALS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deaf life narratives in times of transition.;1/11/2015;31/10/2017;;The research project concerns deaf people who use a signed language, such as BSL (British Sign Language). It investigates the potential of a culturally familiar practice, storytelling, as a means of promoting agency, resilience and better well being. Using techniques of narrative therapy, narrative analysis and grounded theory, the project will explore the significance of life story work to enhance well being from a cross cultural perspective, engaging with deaf migrants from diverse nation states. It will result in a life story instrument, piloted during the study that exploits the visual learning strengths of deaf people and the properties of visual (non-textual) languages through digital media. It extends current research on narrative methods as a form of cultural brokering and emancipatory methodologies within critical deaf epistemologies.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195163;655732;WhereWolf;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The history of wolves, and their contribution to adaptation and phenotypic diversity in dogs;1/09/2016;31/08/2018;;The resurgence of the gray wolf in Europe and its re-emergence in northern Europe, including Denmark, makes this an ideal time to study the wolf populations and their relationships to dogs. The evolutionary relationship between wolves and dogs is an area of active research. There are several key questions about dog domestication that remain unanswered, such as whether the dogs were domesticated once or several times, and the location of the domestication event(s). The ability to answer these questions has been hampered by multiple factors such as unavailability of a large number of wolf samples, the poor elucidation of the relationship between the wolf subspecies and the lack of an appropriate wolf reference genome. The resources available at the lab of Prof. Tom Gilbert at the Center for GeoGenetics in the University of Copenhagen will let me handle all these concerns effectively. As parts of several ongoing efforts, Prof. Gilbert has sequenced the genomes of a large number of wolves sampled from across the globe. Combining this resource with publicly available wolf and dog genome sequences and ancient canid genome sequences (currently being processed by the Gilbert lab in collaboration with Prof. Greger Larsen, University of Oxford), will allow me to address three aspects of canid evolutionary and population genetics: 1) the relationship between the different wolf subspecies, 2) the dog domestication event and its location and 3) the extent of fine scale local gene flow between dogs and wolves. Incorporation of the ancient samples along with the availability of a large number of sequenced canids will also let us answer questions about adaptive introgression from local wolves and will allow us to reconstruct the genome of the wolf that is ancestral to all dogs. The large-scale sampling and incorporation of ancient canids will shed new light on the evolutionary history of the canids. The findings of the project will be useful in the management of wolves in Europe.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195285;656530;ETAB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Entangled Twin Atom Beams;1/04/2015;31/03/2017;;Many of the fascinating phenomena predicted by quantum mechanics, like non-local correlations and entanglement, were implemented with photons in the framework of quantum optics. It is today a mature field with applications emerging in cryptography, random number generation, and quantum computation. Based on the analogy between matter waves and electromagnetic waves and on particle-wave duality, quantum atom optics started to develop recently, thanks to the development of tools for matter wave manipulation. A crucial point for the success of quantum optics was the availability of twin-photon sources, based on a non-linear medium. Very recently, several approaches towards realizing twin-atom pairs have been investigated (most notably by the applicant and the host institution of this proposal) and successfully realized. The ETAB project will use this new twin atom beam (TAB) source to implement quantum atom optics experiments. Characterization of the resulting strongly correlated states will be performed through measurement of correlation functions. These experiments will go beyond the analogy with quantum optics due to fundamental differences between atoms and photons: mass and intrinsic nonlinearity due to interactions. This second property allows high efficiency twin atom beam generation, with an important pump depletion. This allows us to investigate new physics, including beyond linear response, quantum simulation, and non-equilibrium physics. Furthermore, by preparing the twin beams in an entangled state, we will perform the first test of Bell inequalities with untrapped atoms, which could rule out spontaneous decoherence or gravitational nonlinearity models.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNISCHE UNIVERSITAET WIEN;AT;;; 195468;657544;ATTOCHEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Attosecond imaging and control of chemical dynamics;1/11/2015;31/10/2018;;Femtosecond laser pulses can be exploited to trace the ultrafast motion of electrons (attosecond physics) and study the properties of molecules, and the changes they undergo, on the atomic scale (femtochemistry). Suitable tailoring of the laser fields even allows for controlling the electron and nuclear dynamics within molecules and thereby steer chemical reactions towards a desired outcome (coherent control). Despite a wide range of perspective applications in fundamental science and industry, our capabilities to exert control on chemical reactions, and our understanding thereof, have been very limited. In the proposed work, I will develop and employ a novel experimental technique, which will allow (a) controlling light-induced chemical reactions in a wide range of molecular species efficiently, and (b) imaging the electron and nuclear dynamics underlying such reactions on their natural timescales. My work will go significantly beyond the state-of-the-art and thus contribute to the development of coherent control and our microscopic understanding of photochemical reactions. The advancements become possible by combining the latest laser technology with the expertise of all participants. The proposed MSCA will complement my scientific skills, both experimental and theoretical, and will provide me with required transferable skills to reach my long-term goal of establishing my own research group in Europe. The new scientific development will contribute to consolidating the European Leadership in the field of Attosecond Physics.;243352,8;243352,8;H2020-MSCA-IF-2014;MSCA-IF-GF;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;DE;;; 195130;655559;SSAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Future bio-pesticides for EU: unlocking the code of Saponin Structure-Activity Relationships for use in pest management;1/03/2016;28/02/2018;;Insect pests are very damaging to worldwide food production, and there is a great demand for new environmentally-friendly bio-pesticides. Saponins are a structurally diverse class of naturally occurring plant defense compounds that are a promising resource for novel and more sustainable pesticides. Due to their detergent-like properties, saponins can disrupt the cell membranes of herbivory pests, cause cell death, and ultimately kill them. Despite the promising potential of saponins as bio-pesticides, little is yet known about which saponin chemical structures are toxic to which specific pest. The SSAR project aims to elucidate the relationship between saponin chemical structures and their biological activities and evolution. First, the genes involved in the biosynthetic pathway of saponins will be identified. Then desired or novel saponins will be produced in plant tissues through metabolic engineering with the identified genes. Finally, purified saponins will be used in bioassays with a range of pest species, to unlock the code of exactly which saponin chemical structures have a given specific biological activity. The new knowledge gained will have great industrial application potential as a generic platform for the production of bioactive compounds from plants and their use for bio-pesticides as an alternative to chemically produced pesticides. The new bio-pesticides will both help to meet societys need for more sustainable food production and to contribute to the development of the knowledge based bio-economy. Identification of genes involved in saponin biosynthetic pathway will also open the possibility to engineer and breed crop with tailored saponin-based pest resistance capabilities. The SSAR will allow me to develop as an independent and mature researcher, and extend my expertise in both academic and non-academic sectors through the training in the host institution and the collaboration with a bio-pesticide and generic agrochemicals innovative company.;212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195332;656817;RvD3-RAVIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Novel Resolvin D3: its Role and Actions in the Resolution of Aortic Valvular Inflammation and Stenosis;1/11/2015;31/10/2017;;Aortic valve stenosis is a progressive inflammatory disorder with poor prognosis if left untreated. Currently the only available treatment is invasive surgical replacement of the valve, therefore new therapeutic strategies are needed. Resolution of inflammation is an active process orchestrated by endogenous specialized proresolving lipid mediators (SPM). These include the resolvins that actively promote catabasis via their potent actions in anti-inflammation, proresolution, tissue regeneration and pain reduction. Recently the complete stereochemistry of resolvin D3 (RvD3) was established. Given its highly potent anti-inflammatory and proresolving actions in murine models and with human cells its role and actions in aortic stenosis (AS) remains to be uncovered. Thus, a goal of this proposal is to elucidate endogenous resolution programs in human aortic valves and define the role and action of RvD3 in AS and calcification. To address this the candidate will employ LC-MS-MS based LM metabololipidomics combined with clinically relevant parameters as well as biochemical and cellular assessments in samples from AS patients. In addition, RvD3 will be used as treatment in a novel preclinical model of murine AS. Implementation of the proposed project will maintain and enhance the candidates position at the forefront in the field of resolution biochemistry with advances into valvular pathology. Unraveling the role of RvD3 and resolution programs in aortic inflammation and resolution may enhance current understanding of the molecular mechanism contributing to chronic cardiovascular inflammation and introduce a novel concept for the pathology AS. Furthermore, it may lead to novel therapeutic strategies with a potential to slow or halt the hemodynamic progression of stenosis via turning on resolution programs.;185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KAROLINSKA INSTITUTET;SE;;; 195251;656337;VEiL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Visualising Engineered Landscapes: an archaeological approach to unlock environmental resilience and sustainability in antiquity;20/07/2015;19/07/2017;;"Contemporary anthropogenic landscapes were shaped by centuries of human action. Land surveying and division were the first forms of widespread landscape engineering performed by pre-industrial societies. Among those, the most complex was unquestionably the Roman Centuriation, which still characterise the rural landscapes of many European countries. Notwithstanding its impact on modern European land organisation, the principles underlying the design approach used by Roman land commissioners are still largely ambiguous. The proposed project thus aims to illuminate the process of landscape engineering undertaken in antiquity by the Roman surveyors and contribute to the discipline of landscape engineering by injecting a new body of evidence into the debate about past land division and design in order to inform models of sustainable practice for contemporary landscape management.
The project integrates archaeological, historical and geospatial information to investigate the forms, impact and endurance of complex engineering on the landscape of Aquileia (Italy), a major city of the Roman Empire. Imprinted with the Roman 'spatial signature', the Aquileian countryside provides an unparalleled opportunity to expand our current understanding and perception of the origins and advances of landscape engineering and its efforts to build sustainable responses to long-term environmental and socio-economic pressures. To achieve its research agenda, this study will develop new methods based on Artificial Intelligence for digitally identifying, collecting, integrating, managing and sharing diverse spatial and archaeological data that are key for the identification of the centurial system elements where they are no longer readily identifiable and will apply a novel approach for defining models of land division application and dynamics in antiquity.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITA CA' FOSCARI VENEZIA;IT;;; 195226;656129;Super MagneFiQuE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Superconducting magnetic-field compatible quantum electronics;1/10/2015;30/09/2018;;"In superconducting quantum electronics, or superquantronics, macroscopic degrees of freedom, like currents and voltages, can exist in a quantum mechanical superposition. This macroscopic quantum coherence has led to the development of circuits behaving as atoms. An exciting new field of research is circuit-based quantum electrodynamics (cQED), in which these artificial atoms are placed in cavities to perform quantum optics in the microwave regime. This cQED architecture is arguably the most promising platform for realizing a full-scale quantum computer. However, a major draw-back of the circuits used for cQED today, which contain aluminum films, is that superconductivity is lost upon applying strong magnetic fields. This limitation poses a fundamental obstacle to interfacing superquantronic circuits with other quantum systems that rely on these strong magnetic fields for their operation. By forming such hybrid systems, new technologies can be developed, such as long term quantum memories for superconducting qubits using highly coherent solid-state spin ensembles, or a topological quantum computer using Majorana Fermions.
The goal of this proposal is to realize magnetic-field compatible superquantronic circuits for the cQED architecture.
A promising new approach is to combine magnetic-field compatible superconducting materials with semiconducting nanowires to build new circuit elements. We plan to develop circuits using these new elements and demonstrate the coherent operation of an artificial atom in cQED in the presence of a strong magnetic field.
The magnetic-field compatible superquantronic circuits we will develop, provide a unique platform to create and study new quantum devices. This fellowship, along with his previous research experience with a wide range of quantum systems, will allow the applicant to define new research directions in fundamental physics and experimental quantum information science, by developing new hybrid quantum systems.";260929,8;260929,8;H2020-MSCA-IF-2014;MSCA-IF-GF;TECHNISCHE UNIVERSITEIT DELFT;NL;;; 195262;656385;ENIRIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electrogenic NItrate Reduction In marine Sediments;1/04/2016;31/03/2018;;"Recently, a novel type of long, filamentous bacteria has been discovered, which are capable of guiding electrical currents over centimeter distances. These so-called cable bacteria were first isolated from marine sediments, and laboratory experiments demonstrate that electrons are passed on from cell to cell along the longitudinal axis of the filaments. This long-distance electron transport radically extends the physiological capacities of prokaryotes, and profoundly changes our understanding of biogeochemical transformations in marine sediments.
In my PhD research, I have documented that in addition to oxygen, these sulphur oxidizing bacteria can also use nitrate as an electron acceptor. This new form of electrogenic nitrate reduction could have important implications for the removal of bio-available N in marine ecosystems. However, the effect of this newly described nitrate reducing process on the global nitrogen cycle, as well as the factors that ultimately control the occurrence, remain unknown.
The goal of this project is to identify the end products of the electrogenic nitrate reduction and the environmental controls that regulate its occurrence. This project will hence provide new insights into the physiological abilities of micro-organisms and improve our understanding of N dynamics in marine sediments, strengthening European excellence in these fields of research.
The goals of the project will be attained by combining state-of-the-art biogeochemical techniques with a novel and interdisciplinary approach based on principles traditionally applied in microbiology, electrochemistry and geophysics.
This project will allow me to work on an up-to-front topic and thus to build up a unique research profile among the large number of researchers in the of nitrogen cycling.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING NIOZ, KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE;NL;;; 195199;655993;FireAndRiskPrevention;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;When the smoke clears: predicting and preventing catastrophic erosion and flooding after wildfires in volcanic terrains;1/08/2015;31/07/2017;;"Wildfires remove protective vegetation, leaving the landscapes vulnerable to catastrophic erosion, landslides and floods. The resulting losses and mitigation costs following wildfires have increased dramatically in the last 30 years due to (i) the population increase, (ii) the rise in fire severity and torrential rains associated with climatic change, and (iii) critical gaps in and limited transfer of knowledge on fire-effects to support decision making. Major advances have been made in the last decade including the development of cost-risk erosion prediction tools, innovative hillslope stabilization treatments and novel approaches to monitor soil redistribution. In Europe, however, their application in post-fire prevention plans is still in its infancy as the necessary soil-specific calibration and effectiveness testing is missing for most terrain types.
In this project I aim to exploit my expertise in Andisols to address this important research and management gap for volcanic regions. These terrains are not only typically very steep, densely populated and highly prone to wildfires, but as they experience some of the most torrential rainfall events worldwide, they are very often subjected to the dramatic consequences of floods, severe water erosion and landslides, which threaten properties and human lives.
I propose to use an innovative field, laboratory and modelling approach and carefully chosen implementation programme, involving the validation and application of novel erosion-risk tools. Where applied, these tools will reduce risks to lives and properties, for southern European countries, savings of over 375 million per year can be expected. The collaborative work plan, involving global leaders in academia, industry and management, not only provides me with multidisciplinary and inter-sectorial training of the highest standard. It also ensures the application of the best science and effective knowledge transfer from academia to the end-users.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;SWANSEA UNIVERSITY;UK;;; 195148;655659;ULISSES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transported cultural landscapes: the role of colonization processes in cultural landscape shaping;1/10/2015;30/09/2017;;European landscapes are the result of millennia of socio-cultural exchange through trading, migratory and colonial processes. Societies largely dependent to their local ecosystems and when societies move their landscapes move with them, creating in this way the so called transported landscapes. The Mediterranean Sea has been the cradle and contact route of ancient and influential civilizations, but little is known about how cultural exchanges, migratory and colonial processes contributed to the cultural landscape shaping of Mediterranean environments. This ancient Mediterranean cultural landscape development achieved a universal importance when, during the colonization of America, the transport of European agro-pastoral landscapes configured a shared cultural landscape heritage between both World regions. Despite its significance in cultural landscape shaping, the study of transported landscapes has been poorly addressed so far. ULISSES project is designed to (1) identify the environmental impacts, land-uses and landscape changes involved in migratory and colonization processes during the Holocene and (2) evaluate the role of transported landscapes in the shaping of cultural landscapes both in Europe and overseas. An integrated approach joining multi-proxy palaeoenvironmental analyses (eg. pollen, non-pollen palynomorphs, charcoal analysis, sedimentology), and the study of archaeo-historical sources will be applied in Mediterranean areas of Spain and California (USA). These have been selected for having ancient colonial relationships and for accounting for a long and intense history of colonial, migratory and socio-economic exchanges. By analyzing the cultural dimension of landscapes and the mobility of cultural landscapes, ULISSES will significantly contribute to 1) a better understanding of the European Mediterranean cultural landscape heritage, 2) the formation of European identities and cultures and 3) the influence of European culture and societies in the World;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195308;656647;MicroEcoEvol;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Ecological and evolutionary forces shaping microbial diversity in freshwater blooms;1/06/2015;31/05/2018;;'Bacterial communities dominate the living biomass on Earth and contribute significantly to all global cycles of matter and energy. However, due to the high genetic heterogeneity of the ecosystems and their richness in diverse microbial species, our knowledge of bacterial communities remains limited. Therefore, in order to understand any bacterial community's ecology and predict how these communities and their respective ecosystems will respond to environmental changes, we need (i) to identify the different ecologically distinct microbial populations (or 'clusters') that compose it, and (ii) to determine the interactions between clusters, and how they evolve. To address these challenging goals, this study will use the model system of Microcystis, the cyanobacterium that is mainly responsible for toxic algal bloom in lakes worldwide. The goal of this project is to (i) determine how (and if) Microcystis is specialized into different ecologically and genetically distinct clusters, (ii) to track how the Microcystis populations (or clusters) respond to environmental changes (pH, temperature, pollution from fertilizer runoff) and biological factors (viruses that prey on bacteria). This will allow us to understand how Microcystis populations change and adapt over time, helping us to predict and prevent harmful blooms. Using a unique multidisciplinary approach mixing ecology and evolution, and combining observations from natural time-courses in lakes, in situ experiments in microcosms within lakes, and in vitro experiments, this project will provide an unprecedented understanding of how changing regimes of natural selection, imposed by environmental and biological factors, shape microbial communities on the scales of populations, genomes and genes. This project will provide major advances in bloom understanding, in prediction by the identification new genetic biomarkers and in prevention by defining the conditions under which phage therapy might be a practical strategy.';255349,8;255349,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE UNIVERSITY OF EXETER;UK;;; 195453;657479;SMI REP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating eukaryotic replisome dynamics at the single molecule level;1/08/2015;31/07/2017;;For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each cell consists of ~6 billion pairs of nucleobases (base pairs, bp) assembled as a polymer 2 metres long and 2 nanometres in diameter, with the structural form of a double helix. For a mammalian cell to divide, this deoxyribonucleic acid (DNA) must be copied in a time frame on the order of 1 day, or ~70,000bp a second. DNA replication is common to all 3 domains of life, bacteria, archaea and eukarya and is accomplished by a complex of proteins. This proposal brings together a researcher of great proficiency in single molecule methods and multidisciplinary research with the Single Molecule Imaging group at the London Research Institute, one of the world leading centres in DNA replication. Combined, we will build unique instruments and develop single molecule assays to understand the molecular gymnastics of DNA replication in eukaryotes. We will elucidate rates of DNA unwinding by eukaryotic helicases and establish enhancements by association with other proteins. We will also study replisome dynamics by observing synthesis of DNA on custom templates in real time. This will allow detection of replication loops and stalling that may occur. We will also examine the mechanism of lesion bypass. The insight gained is impossible with classical biochemical techniques, as individual replisomes are observed in real time rather than measuring an average of a population. Our methods will reveal heterogeneities and obtain precise quantitative details of the dynamics. Features such as pauses and back slips will enable the study of intermediate states and conformational changes linked to replisome dynamics. This proposal will satisfy academic curiosity of understanding life at the most fundamental level but will also increase our knowledge of the how the cell works and thus becomes the building blocks for disease treatment and cures of the future.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE FRANCIS CRICK INSTITUTE LIMITED;UK;CANCER RESEARCH UK;UK; 195115;655478;NeoGenHeritage;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neotithic transition in the Iberian Peninsula: reviewing an old question from new technological and computational genome wide approaches;1/09/2015;31/08/2017;;"The research goal of this proposal revolves around a widely debated topic in archaeology, anthropology and population genetics: the dynamics of the spread of farming into Europe, or Neolithic transition. For a long time, this key event that was to define modern Europeans has fuelled a dichotomic research debate. In short, did the Neolithic spread into Europe as the result of cultural or demographic diffusion? While many approaches can be attempted, in the last few years, ancient DNA (aDNA) studies have strongly contributed to shedding light on this topic, through the recovery and analysis of an increasing number of mitochondrial and nuclear genomes from prehistorical human samples. Far from closing the debate, these palaeogenomes are revealing a more complicated scenario, where the times, paths and genetic legacy of the Neolithic diffusion seem to have been different in different geographic areas. Furthermore, as the genomic data increase, the aDNA field is soon facing the challenge of evolving from a research area largely based on technical development for the recovery of short DNA fragments, to the analysis of larger datasets (ultimately, whole genome data) in the context of human population genetics.
I therefore propose an interdisciplinary project aimed to increase our knowledge on the Neolithic transition by generating, for the first time, genome data from ancient human remains from the Iberian Peninsula at the times of the Neolithic transition. Having been the last region of Europe reached by the Neolithic diffusion, the IP is a crucial area for understanding the relative role of migration and cultural changes. By combining modern technologies for the recovery of ancient genomes, with state-of-the-art statistical data analyses in the context of human population genetics, this project will contribute to the development of practical and theoretical approaches to make the most of aDNA as a powerful research tool in the fields of archaeology and antropology.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI FERRARA;IT;;; 195317;656757;Tolltum;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Role, regulation and targeting of nucleic acid-sensing TLRs within the tumour microenvironment;1/10/2015;30/09/2017;;Inflammation is an integral part of carcinogenesis. Several different cells of myeloid, lymphoid and non-hematopoietic origin contribute to the strong link between cancer and inflammation and maintain a pro-tumoral environment. The complexity of this environment and the diversity of tumours lead to distinct responses during tumour immunotherapies. Nucleic acid-sensing (NAS) TLR ligands are an essential component of anti-tumour strategies to induce efficient tumour-specific adaptive immune responses. NAS TLRs can also detect nucleic acid released during tumour necrosis, thereby modulating the tumour microenvironment. Interestingly, NAS TLR signalling can induce cell death via apoptosis or induce pro-tumoral survival and proliferation of cancer cells. These opposing effects of NAS TLR ligands may be due to the differential response of distinct tumour-associated cells to TLR ligands. Indeed, the individual response of subsets of tumour-associated cells remains unclear, thus making it difficult to predict the outcome of tumour immunotherapies. Furthermore, the expression and regulation of NAS TLRs in tumour-associated cells remains unknown. Using ex vivo cultures from adenocarcinomas and melanomas, we will systematically analyze the expression of all NAS TLRs on sorted cells. Using cutting edge technologies, we will dissect the role of TLRs in modulating the tumour microenvironment, which will provide novel insights into our ability to modulate cellular inflammation in the tumour. This proposal has the potential not only to reveal novel aspects of NAS TLR regulation, but also to provide new targets for the modulation of the tumour stroma and the infiltrating cells during carcinogenesis.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195270;656442;membrane-ezrin-actin;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Membrane-ezrin-actin interactions mediated by ezrin binding proteins in reconstituted systems;1/01/2016;31/12/2017;;"Microvilli are tube-like membrane protrusions containing bundles of actin filaments located at the apical surface of epithelial cells. A key component of these microvilli is ezrin, a member of the Ezrin/Radixin/Moesin protein family, which provides a regulated linkage between the plasma membrane and the actin cytoskeleton. The critical role of ezrin in microvillar morphogenesis has been demonstrated. However, how ezrin is recruited to the apical surface of the cells and how ezrin contributes to the stability of microvillar morphogenesis remain elusive. Recently, a few ezrin binding partners, such as EBP50 and Eps8, have been identified and shown to function synergistically with ezrin in membrane and actin remodelling in cells. The precise mechanisms and implications of their interactions in microvillar morphogenesis are not well understood. Lately, I-BAR domain protein IRSp53 was found to colocalize with ezrin in microvilli and interact with both EBP50 and Eps8, as ezrin does. Given that I-BAR domain proteins participate in the formation of many cellular protrusions, such as filopodia, ezrin and I-BAR domain proteins may work synergistically in membrane remodelling.

The goal of this proposal is to better understand the interaction of ezrin, the membrane and actin, and the role of ezrin binding proteins and I-BAR domain proteins in this interaction by using reconstituted model systems based on purified proteins combined with supported lipid bilayers or giant unilamellar vesicles. In parallel, potential common binding partners of ezrin and I-BAR domain proteins will be identified, and their role in mediating the interaction of ezrin and I-BAR domain proteins on membranes will be studied. This project will thus lead to an improved understanding of the membrane and actin remodelling activity of ezrin, and advance our knowledge of cell and eventually tissue morphogenesis.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT CURIE;FR;;; 195213;656157;Pro-Membrane;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Amphiphilic Peptoids as General Tool for Membrane Proteins Stabilization and Crystallization;1/05/2015;30/04/2017;;Pro-Membrane is an extensive project which has been structured to face multiple tasks of different levels of innovation and risk. In its longest-term and most ambitious goal, Pro-Membrane, aims to face the still not solved challenge of stabilize and crystallize Membrane-Proteins (MPs). This study will use, as innovative tool, well-ordered and disordered functionalizable amphiphilic peptoids for structural determinations. Peptoids could indeed succeed where other classes of molecules previously failed, answering to the pressing need of a new method able to establish the specific interactions to stabilize and crystallize each MP. Their peculiar nature helps them to easily cross the membrane and their modular synthesis give access to an infinite combination of molecules. Despite their interest, a systematic and comparative study of their physical properties and self-assembly capacity was never done before. The multidisciplinarity of this work, between Organic Chemistry, Biophysics, and Structural Biology will be achieved through a strict collaboration between all the participants. Training through research and implementation activities have been planned to maximize the candidates profile in order to support his career perspectives.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE BLAISE PASCAL CLERMONT-FERRAND II;FR;;; 195236;656259;PoreSelect;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Macroporous Polymer Monoliths as a Low-Cost Bioanalytical Platform for Biopharmaceutical Glycoprotein;1/02/2016;31/01/2018;;Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are biologics. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide problem. This project aims to develop a low-cost and easy-to-produce glycopeptide separation platform. This will be based on highly porous polyHIPE structures obtained from fast and scalable polymerisation and subsequently functionalised with reactive groups. The latter will be employed in the conjugation with novel recombinant lectins that have very selective carbohydrate-binding prop-erties. The separation of closely related glycoproteins will be investigated. Moreover, the integration of the lectin conjugated porous polymers into a device format will be addressed. This is a highly interdisciplinary project at the interface of polymer and material science, biotechnology and separation science. The applicants diverse experi-ence in academic and industrially informed projects makes him an ideal match for this project. It provides a unique environment for the researcher to develop his skills supported by unique scientific and complementary training and accelerate his academic career in applied material science. The dissemination of research results will target the professional audience as well the general public through outreach activities.;175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL COLLEGE OF SURGEONS IN IRELAND;IE;DUBLIN CITY UNIVERSITY;IE; 195100;655392;SexDiff;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sex differences in expression in the shared genome;1/03/2016;28/02/2018;;"Males and females in many animals are strikingly different in behaviour, physiology, shape and form. In humans, rates of ageing and disease incidence vary markedly between the sexes. Moreover, sex differences in response to medical therapies and treatments have recently become an area of major biomedical concern. Because there are very few sex-limited genes, sex differences are largely a product of contrasting gene expression patterns between males and females4. Despite their ubiquity and clear biomedical importance, the evolutionary causes of sex differences in gene expression remain essentially unknown and pose a fundamental problem for biologists: How do sex differences evolve given that the sexes largely share the same genome?

My research addresses this fundamental question using two approaches: (1) a data-driven, large-scale phylogenetic approach, and (2) an experimental manipulation of chromosome dose in Drosophila melanogaster. The results from this project will create comprehensive understanding of sex-specific gene regulation and evolution. This broad research has important implications for medical, developmental and evolutionary studies of sex differences and addresses a key aim, as identified by the European Commission, for research excellence in Horizon 2020.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195301;656721;MECHANOPROTEASES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Single Molecule Study of Protease Mechano-Specificity;1/04/2015;31/03/2017;;Single-molecule enzymology offers new possibilities to dissect catalytic reactions that were previously unapproachable using biochemistry techniques conducted in the bulk. In particular, recent discoveries conducted at the single molecule level, such as the unanticipated force-mediated protein degradation pathway in the proteasome, highlight the close relation between mechanical forces and proteolysis in vivo. While much has been discovered about protein enzymology in the recent decades, the question of how mechanical force affects enzymatic catalysis remains vastly elusive. The main goal of this proposal is to understand the mechanobiology of proteolysis at the single molecule level. We will use the newly developed force-clamp spectroscopy technique, together with molecular biology engineering techniques and bioinformatics structural analysis to elucidate the molecular mechanisms that underlie protease catalysis under mechanical force. Successful enzymatic activity relies on the enzyme:substrate (E:S) assembly. Upon mechanical unfolding, proteins unveil their buried substrate sites, also called cryptic sites, thus favoring the formation of the E:S complex and ultimately permitting the subsequent chemical reaction. A key feature of recent mechano-chemistry experiments at the single bond level is that the rate at which the reduction of a protein disulfide bond occurs in the presence of a nucleophile is exponentially dependent on the stretching force. Hence, it is tempting to speculate that, in the case of an enzymatic reaction, the catalytic rate will be also force-dependent. We anticipate that the curved geometry of the bound substrate inhibits the E:S assembly at high-forces, implying a novel mechano-specificity character of proteases. Within a multidisciplinary approach, here we propose a series of innovative experiments to directly probe the effect of force on the kinetics of protease hydrolysis.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195239;656272;AlFHoNSo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Analysing Forest Hydrocarbons with Networks of Sensors;1/06/2015;31/05/2017;;Forested ecosystems play a central role in the Earth system. However, whether for the regulation of atmospheric carbon dioxide, the uptake of ozone or the emission of reactive carbon, small-scale variability inherent in forests makes their parameterisation in models difficult. Recent developments in cheap, small, lower power sensors and robust network technology can ultimately drive a range of science communities (ecology, atmospheric chemistry, carbon flux) towards a new concept of a highly instrumented forest. Within a highly instrumented forest, the environment is autonomously observed using large numbers of low cost sensors, giving a wide spatial perspective on forest interactions with the atmosphere. Such an approach contrasts markedly with the current paradigm where a single site, equipped with a small number of highly specialised instruments, is treated as being representative of a whole forest. This fellowship will develop and apply a unique sensor network for assessment of the spatial and long-term temporal variability in volatile organic compounds (VOCs) emitted by forests. VOCs play a vital role in controlling the regional and global concentration of ozone, aerosol and methane, all of which are key players in climate change and air quality degradation, but the spatial heterogeneity of emissions from forests is unknown. The sensors will be tested both in the laboratory and in small-scale trials. The fellowship will culminate in the application of a sensor network in a UK Forestry Commission research forest, to resolve for the first time the true spatial and temporal variability of biogenic VOCs throughout a forest canopy. This fellowship will exploit the fellows experience gained in the UK and USA, and the world-leading expertise at the University of York to produce new earth system science and a transferable chemical technology applicable to other research questions, whilst propelling an exciting researchers career onto the highest scientific track.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;University of York;UK;;; 195428;657296;SCDCDC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Design of Switched Capacitor DC-DC Converters Suitable for Wireless and Bio Sensor Applications;1/04/2015;31/03/2017;;"Ever increasing value and cost of energy has led the researchers to focus their efforts in energy efficient and cost effective systems. Additionally, the wide spreading of wireless technologies and mobile platforms require highly cost effective and energy efficient solutions for affordable products such as mobile phones, tablets, medical systems etc. that have decent performance with long battery lives. This proposal focuses on the intersection of these two trends and can be defined as energy efficient/low cost integrated circuits for wireless, bio and energy efficient systems.
The objective of this research is to analyze and design highly efficient, scalable and cost effective integrated circuits for highly integrated wireless systems, energy harvesters and bio-sensors. Specifically, we will focus on analyzing and designing Switched Capacitor DC-DC converters as the main goal. These converters eliminate the need of using costly and bulky off-chip inductors and can be integrated fully on-chip for such low power applications. For higher power applications, SC DC-DC converters can be designed to work with cheaper and smaller size off-chip capacitors. In this research, we will analyze and design both versions of these converters to test their performance with critical wireless communication blocks such as VCOs and PAs. This will be the first step in utilizing these converters and switched capacitor systems in wireless systems, bio-sensors and energy harvesting solutions.";157845,6;157845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;ISTANBUL SEHIR UNIVERSITESI;TR;;; 195294;656601;NSCaging;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Behavior and molecular signature of Neural Stem Cells, and changes occurring during aging;1/04/2016;31/03/2018;;In the adult neurogenic niches, neural stem cells (NSCs) generate neurons throughout life. During aging, the number of newborn neurons is clearly reduced, although it is still very debated what specifically happens to the NSCs: do they die, increase their quiescence or change their fate? It is emerging that NSCs are heterogeneous, with different subtypes, in particular quiescent and active NSCs, responding differently to neurogenic stimuli, including aging. However, due to difficulties in distinguishing NSCs subtypes in vivo, their behavior in the physiological environment, their molecular hallmarks, and especially how those are changed during aging are still elusive. These are key questions in neuroscience and stem cell biology. Thanks to the combination of the host laboratory expertise with mine, the current action proposes to develop a strategy to discriminate different NSCs in vivo and shed new light on their behavior, molecular properties and the changes occurring during life. The expected results are going to provide critical information on the regenerative potential of NSCs subtypes and on whether and how the aging phenotype can be reverted, with a consequent strong scientific and social impact.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;NL;;; 195196;655954;SLUW;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A computer-aided study of the Luwian (morpho-)syntax;1/06/2015;31/05/2017;;The present project aims at analysing the morpho-syntactical features of the Luwian language working on the available texts and combining a standard linguistic analysis with the implementation of a statistical analysis of the annotated corpus. By glossing the morpho-syntactical structure of a large selection of both cuneiform and hieroglyphic inscriptions using a protocol derived from and compatible with the Penn Treebank Project and the Leiden Glossing Rules, the research will proceed by isolating, mapping and modelling the regular as well as the anomalous features of the morpho-syntax of one of the most important and still largely unexplored languages of the ancient Anatolian branch of Indo-European. The analysis will also identify and focus on the co-dependant syntactical, morphological, semantic and stylistic phenomena present in the corpus (e.g. syntactic triggering of stylistic features, dislocations, topicalisations). The results of the present research will provide the world of the Indo-European studies with the first comprehensive study ever dedicated to morpho-syntax of the Luwian language.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ARC-Net Applied Research On Cancer Centre, University of Verona;IT;;; 195255;656354;ClOThIlde;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Cluster Observations and Theory Intersection: Providing selection functions and scaling relations to set constraints on the physics of the accelerating universe.;1/01/2016;31/12/2017;;"Astronomy is grappling with a profound issue: the origin of the accelerated expansion of the universe. Is it caused by a mysterious dark energy, or a new aspect of the gravitational interaction? Galaxy clusters, the largest structures in the Universe, will help answer this question. Cluster formation and evolution are driven by the evolution of the universe itself and cluster abundance is therefore a powerful observational tool that tightly constrains the cosmological model, such as dark energy, and key quantities of fundamental Physics, such as modifications to gravitational theory. These constraints complement and strengthen those from other observational probes, such as type Ia supernova (SNIa), gravitational lensing and baryon acoustic oscillations (BAO). Critical aspects in the scientific analysis of cluster surveys are the survey selection function, relating the survey catalogue to the general cluster population, and the relation between the observable richness and cluster mass, the basic theoretical quantity. The establishment of these two elements is critically needed for the exploitation of optical/near-infrared imaging cluster surveys planned by the European scientific community. We propose to fill this need by 1) quantifying imaging survey cluster selection functions and 2) determining the form of the cluster richness-mass relation using a synergy between observations and well-behaved realistic mock catalogues; we will then 3) introduce this information into the Fisher Matrix formalism to predict possible constraints on theoretical models, e.g, the dark energy equation-of-state or modified gravity scenarios. The precision targeted by planned imaging surveys (e.g., Euclid, J-PAS, LSST, WFIRST) surpasses all previous analyses. Detailed evaluation of expected constraints under realistic conditions as proposed by our research lies at the forefront of current effort in field.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195200;656000;BeSec;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Beyond the Secular: Narrativizing religious change in contemporary German novels;1/03/2016;28/02/2018;;The death of God and the disenchantment of the world are central to self-presentations of modernity. At the dawn of the third millennium, however, the worldwide growth of religious fundamentalisms as well as the pluralisation and individualization (but not the disappearance) of faith in the West suggest the need for a more nuanced understanding of the relation between secularity, modernity and religion. This is not only a matter for empirical research in Social, Political and Religious Studies. Modernity, secularity and religion are, in important ways, interpretive categories shaped by cultural narratives through which individuals and societies understand their world. The project Beyond the Secular studies a defined corpus of such narratives: contemporary German-language novels which articulate non-secular and religious experiences and worldviews. Through an interdisciplinary methodology combining close reading and narratological analysis with contextual readings in religious sociology, theology, and political philosophy, the project seeks to determine the potential of literature for the perception and narrativization of religious change in late modern societies.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195221;656139;ISHTAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The travelling astronomers. International collaborations after World War II and the reorganization of European astronomy (1953-1985);1/06/2015;31/05/2017;;"This research project investigates the history of astronomy in Europe after World War II. In the period between 1953 and 1985, a number of international collaborations were undertaken by several European countries, with the aim of strengthening astronomical research in terms of its capacity and facilities. These collaborations culminated in the construction of powerful observational facilities and the implementation of programmes for cooperation in professional research. In this respect, the initiatives taken from 1953 to 1985 inaugurated a new era of European astronomy. Indeed, in this period research facilities were made available in both hemispheres, new research networks were created, and there was a new attitude towards scientific cooperation.
This study will analyse crucial aspects of the development of astronomy in post-war Europe. More specifically, this research will address the interactions among astronomers, scientific institutions, and governments in the light of the quest of new astronomical sites; the connections between scientific, technical, political, and economic issues in the foundation of new astronomical observatories; and the changes in the community of professional astronomers, both in terms of research practice and social organization. Consequently, this study will contribute to elucidate the reorganization of astronomy in post-war Europe. Moreover, it will reinforce the comprehension of the development of scientific research, science policy and international scientific cooperation.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING VU;NL;;; 195224;656132;SolHyPro;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Water splitting by solar energy: From lab-scale to prototype devices;1/06/2015;31/05/2017;;"Hematite is a promising photoanode material for harvesting solar energy by splitting water into hydrogen and oxygen. It has a favorable bandgap energy (2.1 eV), good catalytic activity for water oxidation, low cost, is chemically stable in alkaline solutions and environmentally friendly. However, its water splitting efficiency is limited by electron-hole recombination length and it produces a below threshold photovoltage. The key to increasing the recombination length is supressing defects such as grain boundaries or surface roughness of the photoanode. The second issue is successfully resolved by coupling the photoelectrolytic cell to a photovoltaic cell, a so-called tandem cell with theoretically higher efficiency owing to optimal use of the solar spectrum. Both of these drawbacks are accounted for in this project.
The aim of this project is to optimize the water photoelectrolysis performance of the photoelectrolysis-photovoltaic tandem-cell device by tailoring the microstructure of the thin film hematite photoanods, and up scaling from the laboratory scale to a prototype device. Fabrication of an efficient water-splitting cell is challenging as it consists of several thin film layers. Each of these layers impacts on the performance of the water-splitting tandem-cell.
Up scaling from the lab scale to the prototype scale (10x10cm2) will be carried out in cooperation with PVComB in Germany. This poses entirely different challenges, creating the need for an adapted fabrication sequence and deposition conditions that ensure the adhesion of the ceramic and metal thin film layers. At the end of this project, I personally will have gained expertise in advanced microstructural analysis technique and also in the leadership role, which will enable me to take the next step in my carrier. And, we will have built a fully functional, fabrication-ready device for hydrogen production directly from solar energy. A great leap forward into a society based on renewable resources.";170509,2;170509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY;IL;;; 195438;657361;REGUCB;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Regulating Umbilical Cord Blood Biobanking in Europe;1/10/2015;30/09/2017;;The research proposed for this fellowship is a study of the establishment of national and European regulation on Umbilical Cord Blood (UCB) biobanking in a comparative perspective (the UK, Germany, France, Italy and Spain) and with an in-depth analysis of the implementation of regulation in the everyday practice of UCB practi-tioners, through a bi-national comparison in the UK and Italy. The first scientific aim is to offer an empirically grounded understanding of how regulations and their practical implementation influence the conducting of biosci-entific research and shape the structuring of different bioeconomy regimes in UCB science and clinical applica-tion. The second scientific aim is to contribute to the field of Science and Technology Studies (STS) by develop-ing an analytical approach combining macro-analysis on policy-making and regulations with meso- and micro-level analyses on the practical accomplishment of enacting regulations in everyday research practices, for offering a more comprehensive understanding of governance and policy-making in the field of biomedicine which inte-grate the role of structural factors with that of the agency of actors involved. Given the importance assigned by the European Union to the development of stem cell research and the coordination of biobanks, the proposed research aims also to offer useful policy suggestions for improving the harmonization and optimization of the EU circuit of supply of UCB units for biological research and medical applications. I will diffuse to practitioners and regulators the findings of the research related to the comparative analysis on national regulations, on the ways in which these interact with the EU directives and on how practitioners manage and enact compliance with national regulations, international directives and the exigencies of the global circulations of biomedical objects, standards, and proto-cols in biobanking.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EXETER;UK;;; 195134;655577;LOVe;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Linking Objects to Vectors in distributional semantics: A framework to anchor corpus-based meaning representations to the external world;1/06/2015;31/05/2017;;"Language mediates between concepts in our mind and the things they refer to in the world. Semantic theories are typically biased towards conceptual or referential aspects. My goal is to develop a theory of meaning that takes both aspects into account, and is supported by computational modelling experiments, so that it will also enable computers to match linguistic expressions with entities in the world. This is a highly interdisciplinary proposal that will bring computational linguistics, artificial intelligence, and theoretical linguistics forward.

My model is based on distributional semantics, a scalable and flexible approach to computational semantics that, by inducing meaning representations from naturally occurring data with statistical methods, can model large portions of the lexicon and account for nuances in meaning that pose difficulties to traditional semantic theories. Distributional semantics has so far largely eschewed the reference issue, by testing its models on language-internal tasks. The project bridges this language-world gap, and integrates the distributional framework into a referential semantic theory. The project promises to advance our scientific understanding of language, a defining trait of the human species, and to make significant progress towards building computers we can talk to, with the ensuing strong impact on our everyday lives.

Even though I am an established researcher in computational semantics and also contributed to semantic theory, I still need to fully develop my own line of research to become a leading, independent researcher in Europe. Carrying out the present proposal at the University of Trento CLIC laboratory will be a fundamental step towards achieving my goal, since CLIC is a world leader in distributional semantics. Conversely, my unique profile, addressing theoretical linguistic questions through computational means, will fill a gap in the lab, widening the scope and outreach of the research conducted at CLIC.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI TRENTO;IT;;; 195085;655282;HiDDaProTImA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High-dimensional data processing: from theory to imaging applications;1/02/2016;31/01/2018;;"The unstoppable increase in the volume of data stored, transmitted and interpreted by fixed and mobile devices strongly calls for the study of efficient solutions in processing the information contained in high-dimensional signals. Such need has been reflected in the recent flourishing of research efforts from the statistics, machine learning, computer science and signal processing communities.
Within this multidisciplinary research ground, the proposed project will address the central question that can be formulated as -- what is the maximum level of information contained in large datasets that we can process from a small number of features, and how is it possible to achieve such limit in practice?

Recent advances in information processing have demonstrated that a promising mathematical tool to tackle this question is represented by the Bayesian approach, in which statistical models inferred from training samples accurately describe the data. In fact, the Bayesian framework offers fundamental advantages in modeling high-dimensional signals in terms of mathematical tractability of performance limits as well as enhanced capabilities in information processing.

Beyond the study of performance limits, the proposed project will involve case studies and applications in image processing. The researcher will be able to establish active collaborations with various research groups, in different department of Cambridge University, that test their research results on actual imaging devices.

This project will also form the proposer to his future independent research activity and it will provide him with new mathematical skills and practical implementation expertise with actual imaging systems. On the other hand, Cambridge University will benefit from the cross pollination of ideas brought by the researcher and his collaborators in top institutions in Europe and the US.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195184;655864;SingMet;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of MRI contrast agents based on long-lived singlet states;1/08/2015;31/07/2017;;The goal of the project is the development of new contrast agents for magnetic resonance imaging (MRI) based on the concepts of hyperpolarization and singlet state nuclear magnetic resonance (NMR). Hyperpolarization boosts the detectable NMR signal of the contrast agents by up to 4 orders magnitude and the generation of singlet states conserves the enhanced polarization for a long time, while not giving a directly detectable signal. The NMR signal can subsequently be obtained by chemically breaking the molecular symmetry or by applying radiofrequency pulses. This technique therefore allows for the detection of a NMR signal after minutes instead of seconds compared to state-of-the-art metabolic tracers. A combination of these techniques leads to a nanomolar detection limit of the tracers, which is a remarkable sensitivity for MRI. The chemical transformation which triggers the generation of a hyperpolarized NMR signal may be due to enzymes which are diagnostic of cancer cells. The project leads towards new agents for the in vivo detection and imaging of cancer without the use of ionizing radiation or contrast agents containing dangerous heavy metals. Overall it is planned to develop molecules with nanomolar detection limits upon hyperpolarization, that maintain their traceability for minutes and undergo chemical transformation induced by enzymes, which can be tracked utilizing MRI.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SOUTHAMPTON;UK;;; 195247;656319;IMSTREV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Immune modulation by lymph node stromal cell-derived extracellular vesicles;1/07/2015;30/06/2017;;"Regulatory T cells (Tregs) are essential for maintenance of immune homeostasis and peripheral tolerance. The unique challenge to discriminate between pathogens and commensals requires the dynamic adaptation of Tregs to the microenvironment, particularly in the intestinal mucosa. Accordingly, although Tregs are primarily generated in the thymus, they can be also generated in the periphery, and gut-draining mesenteric lymph nodes (mLN) were shown to display a higher Treg-inducing capacity compared to skin-draining peripheral LNs (pLN).
Our previous data suggest that these site-specific functional differences of LNs can be attributed to fibroblastic reticular stromal cells (FRCs), and the high Treg-inducing capacity of mLN can be imprinted in LN stromal cells by commensal microbiota. To decipher the molecular details of these site-specific immune-modulatory differences we generated immortalized FRCs, and preliminary data suggest that soluble factors secreted by mLN-derived FRCs mediate the high Treg-inducing capacity of mLN.
The present proposal aims to identify molecules secreted from mLN-FRCs that modulate the differentiation of nave T cells into Tregs. Special emphasis will be laid on the novel field of intercellular communication by extracellular vesicles (EVs), and both RNA-Seq and mass spectrometry approaches will be applied to identify the critical factors on a molecular level. To formally proof the functional importance of the newly identified candidate molecules, immortalized FRCs will be genome-edited using CRISPR-Cas9 technology and tested for their Treg-inducing capacity.
Gaining insight into the cellular-subcellular interactions and major molecular mechanisms of peripheral tolerance and Treg generation anticipates promising tools for future vaccine development and therapeutic applications to treat chronic inflammatory and autoimmune diseases.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH;DE;;; 195413;657237;FreeMi;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Using FREshwater organisms to MItigate the pathogen Batrachochytrium dendrobatidis;1/06/2015;31/05/2017;;Amphibians are currently suffering severe worldwide declines caused by chytridiomycosis, an emerging infectious disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd). So far, disease mitigation strategies have taken a host-level approach, in which only the host-pathogen interactions have been considered. However, recent results have shown that disease dynamics can be affected by pathogen-environment interactions and underscored the importance of the host-pathogen-environment interplay. Indeed, in the field and laboratory, freshwater zooplankton was found to trigger Bd infection in two amphibian species by directly consuming Bd zoospores. This study raises the hope that chytridiomycosis outbreaks could be controlled in nature by natural augmentation of zooplankton. The project FreeMi aims at developing a safe and effective mitigation strategy targeting Bd at the habitat level. To achieve this aim, I will first identify whether amphibians are protected by the species richness, the overall abundance and/or a few key zooplankton organisms able to consume a high number of Bd zoospores. The samples will be collected from two regions: the Pyrenees and Germany. Then, I will identify the local species that are the most efficient at consuming zoospores. I will isolate these species and establish self-maintaining cultures in outdoor microcosms. Finally, I will test the efficiency of the cultures, in single as well as community trials, under biologically relevant conditions. Compared to other approaches, this highly innovative approach lacks the downsides associated with introducing non-native biocontrol agents (such as antifungal chemicals or non-native skin bacteria) in the environment. Moreover, it would allow to treat all amphibian individuals present at a site, of all species and from larvae to adults directly in the field, and therefore would be more cost-effective than individual treatment strategies.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Helmholtz Zentrum fr Umweltforschung GmbH - UFZ;DE;;; 195181;655856;b-lactams C-H activation;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Discovery of novel ?-lactam analogs oriented to control multidrug-resistant bacteria enabled by Pd-catalyzed CH activation of aliphatic amines;1/05/2015;30/04/2017;;In Europe, infections caused by multidrug-resistant bacteria lead to more than 25,000 deaths and expenses of billions of euros per year. These numbers dramatically increase when the rest of the world is taken into consideration. Shockingly, the pace of production of new antibiotics to control such microorganisms is stagnating. Therefore, developing new synthetic tools that enable the synthesis of scaffolds with potential antibiotic properties is crucial. Metal catalysed CH activation represents a versatile tool for building chemical complexity. It mostly relies on directing functional groups to functionalize CH bonds. Recently, Professor Gaunt at the University of Cambridge has uncovered a new CH activation mode that enables the conversion of hindered amines into ?-lactams. The first aim of this project is to develop this new reactivity mode into a versatile transformation that is able to convert a variety of cyclic and acyclic amines into substituted ?-lactam scaffolds. To accomplish this goal, a multi parallel platform based on mass spectrometry, relying either on standard high-throughput procedures or flow chemistry, will be implemented and used to screen a large number of conditions to expand the scope of this new pathway for ?-lactams. The flow chemistry system for reaction evaluation will be design in collaboration with Professors Alexei Lapkin (Dept. Chemical Engineering and Biotechnology) and Steve Ley (Chemistry Dept.) from the University of Cambridge. The readily discovered new conditions for CH activation will then be employed to synthesize a plethora of ?-lactams and ?-sultam analogs starting from simple secondary amines. Finally, in collaboration with Professor David Spring (Chemistry Dept. University of Cambridge), the bioactivity of the resulting scaffolds will be evaluated against multidrug-resistant bacteria.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195279;656493;DEGENHA;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Delivering Hydroacylation: A General and Enantioselective Process;1/04/2015;31/03/2017;;This proposal outlines the development of a suite of truly general hydroacylation catalysts that demonstrate high levels of functional group tolerance, enantioselectivity, broad applicability and ease of use in the laboratory. These advances will be achieved by the development of a new modular ligand system, based on the small-bite angle hemilabile diphosphines. By achieving these advances hydroacylation will become a general and robust disconnection for the synthesis of fine and bulk chemicals, new materials and target molecules.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195206;656093;SynOptic;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Synthetic Gauge Fields in Quantum Optics;1/10/2015;30/09/2017;;"Synthetic gauge fields have many important physical consequences in quantum optical systems. This fast-growing topic of research is opening up new possibilities for the lossless optical transmission of information, for improved optical components, such as optical isolators, and even for fault-free topological quantum computing. We explore how to push cutting-edge experiments towards these goals by theoretically studying the interplay of synthetic gauge fields with optical nonlinearity, pumping and loss in photonic devices. The systems we shall investigate range from artificial graphene and other condensed matter models simulated with microcavities; to lattices of classical pendula and waveguides; to strongly correlated fractional quantum Hall-like states of light and their exotic excitations. Our work will have an immediate impact through international experimental collaborations and an interdisciplinary approach building on our combined range of expertise. We will exploit concepts and techniques from diverse research areas including quantum fluids, topological phases of matter, solid-state systems and non-equilibrium physics. Our project couples the investigation of novel phenomena arising from gauge fields in many-body systems with the hunt for new and improved technological applications in photonics.";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195287;656547;NeuArc2Fun;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biological neural networks: from structure to function;1/03/2016;28/02/2018;;The present project lies at the connection between theoretical and experimental neuroscience. It investigates how information is processed in neural networks with feedback, via the firing activity. On the one hand, the past decades have seen a growing interest for the analysis of the functional connectivity, namely how the spiking activity of neural populations is organized spatially and temporally. These activity patterns are hypothesized to form the basis of neural information, i.e., how neurons collectively encode information. On the other hand, experiments have revealed the complex design of the neural circuitry with many levels of organization, from the local connectivity of neurons to broad-scale pathways between cortical areas. NeuArc2Fun aims to develop a recurrent neural network model that bridges these structural and functional levels. The advantage of this model-based approach is the ability to make predictions about the role of each component of the model - in particular, its connectivity - in shaping neural activity. A key issue is to keep a balance between the mathematical tractability and biological realism in the model. To address this trade-off problem, NeuArc2Fun focuses on the mesoscopic level, namely scales at which many interacting neural populations can be simultaneously recorded by current state-of-the-art experimental techniques, such as electrode arrays. In practice, experimental data from the visual cortex will be used to tune and test the network models. In turn, gaining precise knowledge about neural cognitive processing will be applied to design experiments and test new ideas for information coding in networks. To a broader extent, this project will also benefit to applications that involve information decoding and interaction with the brain, e.g., neural prostheses and brain-machine interfaces.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitat Pompeu Fabra;ES;;; 195185;655866;Active implants;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Active implants: Engineering microstructures of functional ceramics for stimulated bone growth;1/09/2015;31/08/2017;;"The aim of this study is to develop piezoelectric ceramics for the use as bone replacement materials utilizing their piezoelectric behaviour to stimulate bone and vascular cell growth. The work is based on the finding that mechanical and electrical stimuli exert a strong influence on the osseogenesis on the cellular level. As piezoelectric ceramics develop electric surface charges under mechanical load it is expected that they accelerate the healing process and support the development of a strong bond between bone and implant.
The quality of bone and vascular ingrowth is determined by various factors such as biocompatibility of the replacement material, surface morphology and electric surface states. Especially the porosity of the ceramic is of crucial importance as the pores have to be large enough and of open structure to allow ingrowth of both bone and vascular cells. However, increasing porosity is likely to alter the local piezoelectric behaviour and by this the local surface charges responsible for cell growth stimulation. To pave the way for the development of piezoelectric implants it is crucial to understand the influence of microstructural features such as porosity and grain size on the piezoelectric properties. I will approach this task by developing biocompatible ceramics with a wide range of microstructural characteristics. I will investigate the influence of porosity and grain size on a macroscopic scale using piezoelectric testing techniques, on a mesoscopic scale employing Piezo Force Microscopy and on the structural scale via diffraction studies. The biocompatibility as well as the influence of the piezoelectric behaviour on the osseogenesis will be clarified by in-vitro cell experiments on unpoled and electrically poled ceramics. The knowledge gained will form the basis for the development of a new class of implant materials exploiting the piezoelectric characteristics to improve the healing process and to create long lasting interfacial bonds.";208400,4;208400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU;NO;;; 195209;656086;AllergyBLOCK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Blocking peanut allergy through protective IgG antibodies;1/10/2015;30/09/2017;;"Food allergies are chronic diseases of increasing prevalence for which there is no approved treatment other than food allergen avoidance. Among all food allergies, peanut allergy is a particularly important public health problem since peanut allergy tends to persist throughout life and is more likely than other types of food allergies to cause severe shock (i.e., anaphylaxis) and death. The current paradigm states that peanut allergy is mostly triggered by IgE antibodies. Evidence derived from mouse models indicates that some IgG isotypes can also mediate allergic reactions, but the roles of human IgG in peanut allergy remain unknown.

Among the potential treatments for peanut allergy under investigation, oral immunotherapy (OIT) appears very promising since subjects completing OIT tolerate food challenges despite persistent high-titers of IgE in the blood. OIT consists of the administration of slowly increasing doses of the allergenic food and is associated with the production of large levels of IgG, but a direct link between these antibodies and the beneficial effects of OIT has not been demonstrated.

We hypothesize that peanut allergic patients produce both pro-allergic and protective IgG, and that successful OIT is associated with an increased production of protective IgG that are particularly potent at blocking the allergic reaction. We propose to test this hypothesis by developing and exploiting humanized mouse models of peanut allergy, combined with the use of clinical samples and purified IgG from peanut allergic patients completing a phase 2 OIT clinical trial. Finally, we aim at establishing the proof of concept that recombinant protective human IgG could be used to treat peanut allergy and improve the safety and efficiency of current OIT protocols.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;INSTITUT PASTEUR;FR; 195232;656240;EBUCAI;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;European Banking Union and Current Account Imbalances;1/02/2016;31/01/2018;;"Financial liberalization and cross-border banking underpin a striking global trend: while creditor countries had net financial claims on debtors of 20% of GDP in 1980, by 2010 this had risen to 70%. In accounting terms, such international wealth re-distribution materializes via current account (CA) surpluses by creditors and deficits by debtors. Hence the interest in what drives such CA imbalances, their desirability, and sustainability. The recent Eurozone crisis brought further attention to the issue: Greece, Ireland, Portugal, and Spain all had unprecedented CA deficits in the run up to the crisis, and studies indicate that such high deficits helped trigger it.

The MAIN OBJECTIVE of this project is to deepen understanding of the links between CA imbalances, cross-border banking and credit. Much of CA flows consist of purchase/sale of debt contracts between residents and foreigners, and since up to two thirds go through banks, the accounting link is clear. Unclear is the behavioral link: What motivates such flows and makes them very risky at times? This projects novelty is to build a model of this behavioral link, focusing on the Eurozone.

This main objective WILL BE ACHIEVED BY:
- A new general equilibrium model featuring international risk-taking banks with potential externalities on the economy and which can amplify CA imbalances
- A new database on banking indicators and macro-determinants of CAs
- Model estimates using O2 and state-of-the-art empirical methods
- Assessment of risk thresholds and welfare of regulatory policies
- Scenarios for intra-Eurozone imbalances under the EU banking union

This research is HIGHLY RELEVANT TO THE WORK PROGRAM because unexplained CAs expose countries to undetected risks, and studies on Eurozone CAs do not model bank behavior thus overlooking a main component of imbalances. This research is timely because growing cross-border banking affects imbalances and understanding such links is key to EU banking union policies.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT FUER HOEHERE STUDIEN - INSTITUTE FOR ADVANCED STUDIES;AT;;; 195169;655771;DiverseRoots;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Drivers of Root Dynamics in Diverse Plant Communities;1/01/2016;31/12/2017;;"There is increasing evidence for the positive effect of greater plant species diversity on primary production, nutrient retention, erosion resistance and stability in response to changes. Many of these benefits can be directly related to the rooting system, however, biodiversity research to date has mainly focussed on aboveground responses. Recent methodological advances, including molecular methods to analyse the belowground distribution of different plant species to identify soil biota, and advances in tracer methodology now offer new opportunities to increase our insight in these belowground properties and their drivers.
The objective of this project is to apply state-of-the-art methodology to 1) assess to what extent biodiverse vegetation improves rooting structure and b) elucidate the main drivers behind these rooting dynamics. The increased understanding of the belowground functioning of biodiverse systems has direct importance for many fields, including the sustainable intensification of agricultural systems and prevention of soil erosion.
In a desk study, I will analyse existing root data in order to assess the differences in horizontal root distribution in monocultures compared to mixtures. This will feed into the design of an experimental root study carried out in the unique Phytotron facility of Radboud University, in which I will combine state-of-the-art molecular techniques with my own expertise in tracer techniques, to investigate root development in species mixtures and its drivers.
This fellowship will be a perfect stepping stone in achieving my career goal to become a researcher at the top of the interdisciplinary field of plant-soil interactions in biodiverse systems. My quality as a researcher will be hugely improved by the new skills and deepened knowledge that I will acquire in this fellowship. My secondment at a Water Board will facilitate stakeholder interaction and dissemination in a field in which my research is directly applicable.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING KATHOLIEKE UNIVERSITEIT;NL;;; 195398;657139;STROMAMECH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Targeting stromal cells to modify tumor mechanical microenvironment and optimize drug delivery;1/05/2015;30/04/2017;;Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of standard chemotherapies for many cancer types (e.g., pancreatic and breast cancers) is primarily attributed to these agents never reaching cancer cells in amounts sufficient for complete cure. In solid tumours, blood vessels are often compressed, drastically reducing perfusion, thus resulting in insufficient drug delivery. Vessel compression is a consequence of mechanical stresses accumulated within the tumour during progression. Alleviation of these stresses has the potential to reopen compressed vessels and improve tumour perfusion. Here, the applicant proposes to test the hypothesis that judicious depletion of stromal cells, namely the cancer-associated fibroblasts (CAFs), has the potential to alleviate stress levels in highly desmoplastic and hypoperfused tumours and, thus, enhance chemotherapy. To explore this hypothesis, a combination of cutting-edge computational and experimental techniques will be employed. Specifically, a structure-based biomechanical model will be developed to analyse the contribution of CAFs to the generation and transmission of forces within a tumour. Subsequently, in vivo studies will be performed in mice to validate model predictions and identify the degree of CAF depletion that optimizes the efficacy of treatment. Successful completion of the proposed research will reveal the role of CAFs on the biomechanical behaviour of tumours and contribute to developing a therapeutic strategy for treatment of hypovascular tumours. Therefore, the proposal negotiates a subject of considerable importance for European society and beyond. Furthermore, the proposed research and training will establish a bidirectional transfer of skills where the applicants expertise in cell mechanics will be complemented by the Hosts in cancer biophysics, thus enhancing the applicants scientific potential and professional maturity, and promoting European research.;151648,8;151648,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF CYPRUS;CY;;; 195166;655761;EXTREME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Do extreme climatic events facilitate plant invasions?;1/04/2016;31/03/2018;;Extreme climate events (ECEs) are projected to increase in magnitude and frequency as global warming intensifies the global water cycle. Global warming is also changing species distribution patterns by affecting native plant communities and by enabling alien species to expand beyond their native range. We increasingly realize that climate change and biological invasions act together, leading to even more dramatic outcomes. However, how ECEs will affect the incidence and strength of biological invasions remains poorly understood. Therefore, the overall objective of EXTREME is to develop a mechanistic understanding of how increased climatic variability and ECEs affect alien plant invasions. I will relate the incidence of species invasiveness with climate variability and the occurrence of ECEs, using drylands as study system. A novel approach to develop further understanding is the inclusion of genomic features in explaining the response to ECEs. A modelling approach will be combined with a common-garden experiment to study the effect of drought and heavy rainfall on the performance of native and alien plant species in a model dryland system in South Africa. EXTREME will allow me to diversify my individual competence by acquiring new skills (statistical and climate modelling and GIS) and competencies (academic leadership, proposal writing, project management). EXTREME will strongly benefit my inter-sectoral and interdisciplinary expertise and strengthen my international network, which is also beneficial for the host. A two-way transfer of knowledge is guaranteed since EXTREME combines my expertise in invasion and evolutionary ecology with the hosts expertise in the effect of climate variability and extremes. Therefore, EXTREME is not only expected to catalyse my career development, but will contribute to Europes knowledge-based economy and society by providing invaluable knowledge on climate change and invasive species that is of the highest priority in the EU.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195264;656398;DDRR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dissecting dsRNA uptake in RNAi-based antiviral immunity;1/06/2015;31/05/2017;;Important viral infectious diseases, such as dengue and chikungunya, are transmitted to humans by insect vectors. One of the key factors that modulates whether an insect is competent or not to transmit a given pathogen is its innate immune response. The major antiviral defense in insects is the RNA interference (RNAi) mechanism that is activated by the detection of viral double-stranded RNA (dsRNA). During antiviral RNAi a silencing immune signal is transported from one cell to another to set an antiviral state (systemic RNAi). To be primed, non-infected cells must sense this silencing signal and internalize it. Although dsRNA as a mediator of local antiviral immunity is well established in insects, the effectors of a systemic immune response are not identified. For instance, the identification of the dsRNA receptor in insects remains elusive. This proposal intends to dissect the mechanism of dsRNA uptake in insects with special focus on discovering its receptor. I propose to combine functional (genome wide RNAi screen, in vivo dsRNA oral uptake) with binding (electrophoretic mobility shift assay, surface plasmon resonance) and structural assays (expression, production and studies of complexes receptor/dsRNA) using Drosophila melanogaster as insect model and an array of viruses in order to identify and characterize the dsRNA receptor.To be found, the manipulation of this receptor could help control the insect vectors of emerging viral diseases. Understanding how the infection is controlled within the insect before crossover to the human host could generate new strategies to disrupt pathogen transmission.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT PASTEUR;FR;;; 195118;655489;Next-COMM;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Next-COMM: Event-driven design approach to achieve maximum energy efficiency for the next generation digital communication circuits;1/11/2015;31/10/2017;;"Dr. Christos Vezyrtzis is currently employed in the US as an IBM Research Staff Member, after concluding his PhD at Columbia University in the City of New York! Instead of a life-long career in the US, he decided to take the step back to Europe. Through his unique expertise in continuous-time digital signal processors, he will acquire a career in Europe, establishing himself in the field of next-generation communication circuits.
The primary technical focus is the novel event-driven design approach to achieve maximum energy efficiency for the next generation digital communication circuits. This will lead to a drastic reduction in power cost, environmentally friendly products and significantly prolonged operation time. The novel radios will have a cleaner emitted spectrum, less interference which leads to higher data rates (closer to the theoretical limit). Improvement in energy-efficiency will help the European market get one step ahead of the competitors, mainly in the US and Asia.
Infineon, as the host organization, is highly supportive to this idea gaining one of the top-level experts in asynchronous and continuous-time digital circuits to strengthen the European Semiconductor Industry. Such effort will greatly benefit from Dr. Vezyrtzis extensive skills in the new and upcoming field of continuous-time digital circuits. The Marie S. Curie funding gives Dr. Vezyrtzis the freedom to develop his own strategy to re-integrate in Europe while gaining additional industry experience and support an application oriented research project for future communication solutions.
The career goal for the researcher is to find a long-term position in European research, starting in industry to get an additional set of capabilities while investing his know-how in the project. At the end of the Marie S Curie fellowship he will have clarity about his further path in Europe being qualified for industry as well as for academia.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;INFINEON TECHNOLOGIES AUSTRIA AG;AT;;; 195170;655777;miROMeS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;miRNA biomarkers of Osseous Metastases in Serum from breast cancer patients;1/06/2015;31/05/2017;;Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CLAUDE BERNARD LYON 1;FR;;; 195151;655662;ExplicitDarmonProg;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Explicit Methods for the Darmon Programme;1/09/2015;31/08/2017;;"Elliptic curves are the heart of contemporary research in number theory. For example, their modularity played a crucial role in Wiles' proof of Fermat's Last Theorem. Understanding their rational points is the subject of the Birch and Swinnerton-Dyer Conjecture (BSD), one of the seven $1M Clay Mathematics Institute Millennium Prizes. This proposal is concerned with rational points on elliptic curves and linked to both BSD and modularity.

The Darmon Programme is an ambitious project initiated by Henri Darmon, aiming to provide constructions of points on elliptic curves over number fields, and to prove new cases of BSD. The proposed action is an initiative to extend the Darmon Programme, make known constructions explicit and algorithmic to provide extensive data that will be invaluable to researchers in the field, and guide further theoretical work.

Warwick has one of the largest and most active explicit number theory groups in the world, consisting of 2 professors, 3 lecturers, 8 research fellows and 12 PhD students, making it a natural host for the project. The supervisor Siksek, is a leading expert on elliptic curves, rational points and modularity, with considerable experience in supervising research including 5 Marie Curie fellows.

Masdeu did his undergraduate studies in Barcelona. He completed his PhD (McGill) under the supervision of Darmon, and therefore has intimate understanding of the Darmon Programme. Masdeu then worked as Ritt Assistant Professor at Columbia University before joining Warwick as a postdoc in 2014. Therefore his research experience has almost entirely been confined to North America, even though his ambition is to establish himself as an independent researcher at a prestigious European university. Masdeu has substantial research results with 8 papers accepted in strong journals. This project will integrate him into the European research environment, and give him new skills and research directions to enable him to realize his goal.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195154;655682;BBLOCK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Stereocontrolled synthesis of polypropionates based on building block assembly strategies by lithiation-borylation methodologies;1/09/2015;31/08/2017;;Amongst all natural products, polyketides constitute a very important class due to their broad spectrum of biological activities (eg. antibiotic, antitumoral, antifungal, antiparasitic). Many of these compounds are referred to as polypropionates, which are characterized by sequences of methyl- and hydroxy-bearing stereogenic centres, enabling large numbers of possible stereochemical permutations. The importance of these natural products as therapeutic agents and as biomedical tools together with their structural complexity has made these molecules attractive targets for synthetic organic chemistry. The key to construct these systems, which posses a high level of stereochemical information, is the control of the absolute and relative stereochemistry of each centre. Herein we propose the development of a novel and general strategy for the synthesis of any polypropionate-like molecule based on the construction of a building block assembly platform. This process will capitalize on the well-established lithiation-borylation methodology so complete control of both relative and absolute stereochemistry of all chiral centres will be achieved. The power of the strategy will be demonstrated in the synthesis of the polypropionate core of the antibiotic Streptovaricin U. The successful development of this research will shortcut the synthesis of stereochemically defined polypropionates combining building blocks of varying length. Moreover, the possibility to modify the stereochemistry of any centre will allow access to all known natural polypropionate fragments and will permit the preparation of non-natural analogues too. The development of such an ambitious and innovative project in the University of Bristol will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 195249;656325;EU-BEADS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Early Upper Palaeolithic personal ornaments and behavioural adaptations;1/10/2015;30/09/2017;;EU-BEADS investigates symbolically mediated behaviour of Early Upper Palaeolithic modern humans through the study of personal ornaments. Specifically, EU-BEADS will focus on the Levantine region between 60,000 and 40,000 years ago. The goal is a better understanding of variation and standardisation in shell bead production and use, as well as establishing new criteria for identification of anthropic modifications of marine shell beads. To achieve this, EU-BEADS employs a range of state-of-the-art zooarchaeological and taphonomic methodologies in conjunction with newly learned analytical techniques namely finite element analysis, use-wear analysis and GIS. In addition, EU-BEADS aims to develop a new analytical method to improve quantification of human actions in the production of shell beadwork using geometrics morphometrics. The large shell bead collection of Ksar Akil (Lebanon) will serve as a case study. The high quality, multidisciplinary research results will contribute significantly to our knowledge of Early Upper Palaeolithic behavioural adaptations and of modern human symbolically mediated behaviours in general.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195240;656273;RContext;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Radical Contextualism and the Science of Meaning;1/09/2015;31/08/2017;;"The project investigates the impact that radical contextualism (RC) has upon certain foundational issues in the philosophy of language, formal semantics, and philosophy of science. What motivates RC is the idea that our interpretation of a word, and what we refer to by using it, might be very different on different occasions of use. This suggests that our ability to interpret words, or to understand what they mean, depends in part on our being familiar with certain features of the occasions on which words are actually put to use. However, since communicative occasions are not systematically tractable, this seems to render systematic theories of meaning impossible. My chief objective is to think of a way out of this difficulty whilst taking the intuition behind RC seriously.

The key proposal I aim to develop and defend is that RC does not militate against the possibility of constructing theories of meaning, as is commonly assumed. Instead, what RC does challenge are the ontological commitments typically inherited by such theories; e.g. commitment to the existence of objects that are supposed to play the role of stable semantic values of open-class linguistic expressions. My novel response to the challenge from RC will be to propose two ontologically neutral metasemantic frameworks: dynamic content externalism and methodological internalism. I shall assess main hypotheses on the case of natural kind terms.

The project is interdisciplinary, combining insights and techniques from philosophy and formal semantics. I have a background in philosophy of language but I have no training in formal semantics or theoretical linguistics. Hence, this project, supervised by Prof. Martin Stokhof (ILLC) who specialises in dynamic semantics, represents a remarkable opportunity for me to acquire new formal skills, which will not only be necessary for carrying out the proposed research, but also very important for my future career development.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195272;656463;Soft Gluons;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Soft Gluon Physics and Multi-Loop Calculations;1/10/2015;30/09/2017;;"The start of the LHC at CERN and the discovery of the Higgs boson in 2012 started a new era in particle physics. After fifty years from its prediction, the Standard Model (SM) of particle physics has received its final experimental confirmation. There are many experimental and theoretical observations which suggest that new physics should be present at energies slightly above the electroweak scale. Two years of LHC running, however, made clear that such new physics will show up only as small deviations from the SM. This opens up the quest for precision particle physics. It involves our ability to predict scattering amplitudes with the smallest uncertainty possible, a task which relies on our understanding of quantum chromodynamics. This is currently the main task of the theoretical high-energy physics community, and this project addresses issues that are at the heart of this endeavour. Scattering processes at the LHC involve multiple scales, and very often become sensitive, through multi-loop corrections, to scales far lower than the hard interaction. This is the physics of soft gluons, which is the subject of my proposal. I aim at improving our knowledge and treatment of the physics of soft gluons. I will do this by working in parallel on four tasks:
- calculating soft gluon webs at higher orders in perturbation theory, needed to understand the nature of soft gluon radiation to all-orders;
- developing a framework for the resummation of next-to-eikonal soft gluons, needed for improving our ability to obtain precise prediction at LHC;
- developing tools for automatising the treatment of soft gluon radiation in scattering processes, which will directly serve the experimental community.
- investigating factorisation properties of scattering amplitudes in the high-energy limit, the so-called Regge limit.
These goals are important for the exploitation of the LHC and will have a major impact in the field.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195194;655942;EnAct;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Enacting heritage: The aesthetic dynamics of cultural transmission;1/03/2016;28/02/2018;;"Aesthetic behaviours and expressive activities carry out a crucial role in human cultural evolution. Aesthetic cognition is important for intersubjective attunement already in early childhood, and attends to cultural emergence and transmission of ideas, practices and norms. However, anthropological scholars haven't ever investigated the cognitive dynamics whereby aesthetic behaviours shape the symbolic processes of constitution and re-enactment of cultural heritage. The proposed research project seeks to address this lacuna by dealing with key issues relating to the role of aesthetic behaviours in cultural transmission. The study focuses on how aesthetic and expressive elements are mobilized in the course of social interaction creatively transforming and communicating knowledge.
The originality of the proposed approach lies in the interdisciplinary methodology that has not been used in previous studies of the subject matter. For the first time, a naturalistic and cross-cultural model of aesthetic behaviour will be applied to the context of cultural evolution. Existing naturalistic studies of aesthetics are characterized by a reductionist approach, whereas research on cultural transmission suffers due to the divide between cultural and evolutionary perspectives. This project aims to overcome the traditional opposition of evolutionary psychology versus ethnography through an interdisciplinary study of the multimodal, expressive, symbolic, and non-verbal practices whereby human beings collectively perform and share knowledge.
The principal result of the project will be the first systematic and comparative analysis of aesthetic behaviours as operative components of cultural transmission. This result will be of interest to a broad scientific audience and will enhance several branches of European research and education, including aesthetics, cultural evolution, anthropology of art, and cultural heritage, by combining research methods derived from different disciplines.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES;FR;;; 195103;655406;ROOT BARRIERS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Molecular mechanisms controlling endodermis and exodermis differentiation in tomato roots;15/02/2016;14/02/2019;;The root system anchors the plant and its cells absorb water and nutrients. Since plants are sessile organisms, controlling external compound entry is essential for plant survival. In vascular plants, the endodermis is the innermost root ground tissue cell layer that controls entry to the plant vasculature by formation of a barrier for free diffusion of solutes from the soil. Moreover, many plant species also contain an exodermis layer which also acts as a barrier. The exodermis is located internal to the epidermis layer. In a differentiated state, cells of both layers contain a Casparian strip. In Arabidopsis the Casparian strip is a lignin-like structure that is deposited as a ring in the transverse section of cells and around the secondary cell wall. Recently, the developmental framework of endodermis differentiation has been described in Arabidopsis and some important molecular players identified. Here, we explore whether endodermis and exodermis differentiation are regulated similarly. Since Arabidopsis does not contain an exodermis layer, the proposed project will use the tomato root as a model system to address endodermis and exodermis differentiation at the phenotypic and molecular level. Moreover, we will address whether there are differences among species that grow in different environments similar to the environment in which their growth has been adapted. In order to address this problem, newly developed tools and technology will be used to obtain a tomato root cell-type specific transcriptome as well as data analyses required for system biology and genomic approaches. The proposed project will shed new light on endodermis and exodermis development in tomato at the phenotypic and molecular level and will lay the foundation for study in other plant species.;239191,2;239191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA;ES;;; 195201;656010;MYSTICETI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;The oldest and the rarest - combining insight from both hemispheres to gain a global picture of baleen whale origins and macroevolution;16/11/2015;15/11/2018;;"Baleen whales (Mysticeti), the largest animals on earth, are a spectacular example of evolutionary adaptation and, as predators and nutrient distributors, a major component of the modern ocean ecosystem. Their relatively good fossil record, large ecological impact and the existence of extant species as a source of comparative data make mysticetes an ideal macroevolutionary case study promising fundamental insights into the interaction between biodiversity, evolution, and the physical environment. Previous research into the mode and tempo of baleen whale evolution has been hampered by a historical data bias towards the Northern Hemisphere, poor taxon sampling, and disjunct methodologies. I propose to address these issues through (1) targeted sampling of Southern Hemisphere fossil material to create the most comprehensive and most balanced dataset on mysticete morphology to date; (2) the application of cutting-edge phylogenetic methods, including new Bayesian techniques to simultaneously infer phylogeny, divergence dates, evolutionary rates and ancestral body size; (3) reconstructing past mysticete diversity, disparity (morphological diversity) and shifts in their rate of diversification, as well as ancestral geographic ranges and dispersal patterns; and (4) integrating all available data and results with palaeoenvironmental proxies to test whether mysticete evolution has been driven by environmental change. This project will create a benchmark for future studies as one of the most comprehensive and multifaceted macroevolutionary syntheses for any major vertebrate clade, and provide profound insights into evolutionary processes and the workings of the marine ecosystem.";264780;264780;H2020-MSCA-IF-2014;MSCA-IF-GF;INSTITUT ROYAL DES SCIENCES NATURELLES DE BELGIQUE;BE;;; 195070;655222;Walgo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;What is an Algorithm? Extensional and Intensional Equivalences between Programs;1/09/2015;31/08/2017;;"'Programs and Functons both have a mathematically sound definition. Every programmer has an informal idea of what an Algorithm is, yet no formal definition exists and this idea is likely to differ from one person to the other. Despite their lack of definition, Algorithms are central in Computer Science. Thus, finding a correct definition is a major modern challenge.

This question is not new and has already been studied by many. It is unlikely that we can close it within a two years timeframe. Yet we have identified two novel ideas to attack the problem along three tracks of increasing difficulty thus ensuring results that will drive a future long term project.

The main idea is to avoid a direct confrontation with the definition of Algorithm. We consider 'being the same algorithm' as an equivalence between programs and we study the set of all possible equivalences. This will allow the use of the full mathematical arsenal, from set and order theory to algebra and topology, and guide future researches. The second idea is to allow algorithms to be an infinite object, thus opening more possibilities.

The Researchers already has a permanent Lecturer position. The fellowship will create the condition for defending the Habilitation thesis and thus reach a position of full professorship with a long term research program based on the results obtained.'";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195136;655594;CEFOW;SIGNED;"H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-03-2014;H2020;Clean energy from ocean waves;1/06/2015;31/05/2020;;"The most advanced wave power demonstrations today have showed the feasibility of power generation with single device deployments and MW-scale performance within several testing periods of several years. The next step beyond this is to deploy multiple wave energy converters in MW-scale with improved power generation capability and demonstrate that they are able to survive rough sea conditions over a period of several years. Clean Energy From Ocean Waves (CEFOW) project has an exceptionally good starting point. It has an existing site reservation in a wave power testing centre called Wave Hub, with all the needed infrastructure, including grid connection already in place. In addition, the wave energy converter technology to be deployed in the project has already been tested and proven in real conditions in Scotland.

The ultimate purpose of the CEFOW is to increase the speed of wave power development, decrease the levelised cost of ocean energy by improving technical solutions used for multiple device system, and create an efficient supply chain to support larger wave power projects in the future. To reach these targets, the CEFOW consortium will improve the wave energy converter performance by 50% and raise its availability to 70%; develop new types of dynamic mooring and electrical connections suitable for multi-device deployment and deploy 3MW (three 1MW units) wave energy converters in real world offshore conditions in a grid-connected testing environment. In addition, CEFOW will study the feasibility of on-board and on-shore storage solutions and conduct thorough multi-year environmental, health and safety studies.

The consortium spans the full value chain from research organisations to wave converter technology developers, marine service providers and a large multinational utility company as the operator.";24744113,75;16998022,13;H2020-LCE-2014-2;IA;FORTUM OYJ;FI;"THE UNIVERSITY OF EXETER;GREEN MARINE(UK)LTD;THE EUROPEAN MARINE ENERGY CENTRE LIMITED;WELLO OY;MOJO MARITIME LIMITED;Uppsala universitet;UNIVERSITY OF PLYMOUTH;FORTUM ENERGY LTD;WAVE HUB LIMITED";"UK;FI;SE"; 195257;656359;7DUP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of 7q11.23 reciprocal aneusomy syndromes: from patients to functional pathways (and back);1/04/2016;31/03/2018;;"Technological advances have allowed the identification of multiple rare rearrangements caused by structural and copy number variants (CNVs). The 7q11.23 microduplication syndrome (7dup) and Williams-Beuren (WBS) syndromes are originated by genomic reciprocal rearrangements that result in opposite phenotypic features in the area of communication and sociability. Although WBS has been extensively studied, there is lack of exhaustive studies of 7dup at the clinical and molecular levels. In this project, we aim to compile and characterize a large group of 7dup patients. Moreover, we will actively collaborate with a recently created 7dup support group.
Little is known about the functional mechanisms disrupted by these aneusomy syndromes and the specific alterations caused during brain development. Limitations in the available animal models, lack of quantitative data and limited computational capabilities have precluded the identification of relevant molecular pathways involved in these disorders. This proposal aims to overcome these limitations by applying an integrative multidisciplinary approach involving experimental and computational methods. To generate human neuronal in vitro models, somatic cells from a defined subset of individuals with 7dup and WBS will be reprogrammed to obtain induced pluripotent stem cells and differentiated to neurons. To define neuron-specific alteration patterns in gene expression caused by these CNVs we will perform transcriptome analyses at multiple differentiation stages. Finally, the expression data will be integrated with protein interaction and other systematic gene annotations datasets to perform omic analyses to identify dysregulated pathways.
Our results will help to better characterize at clinical and molecular level the unexplored 7dup disorder; to improve understanding of the functional basis involved in this reciprocal aneusomy syndromes; and to generate a disease model to test and determine appropriate therapeutic targets.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;Universitat Pompeu Fabra;ES;;; 195139;655604;SYNPT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of autophagy in presynaptic protein turnover;1/05/2015;30/04/2017;;Neuronal communication primarily occurs at synapses. Recent studies have suggested a key role for protein synthesis and degradation in the regulation of synaptic structure, function and plasticity by changing the abundance of select synaptic proteins in a spatially confined manner. Remodeling of the synaptic proteome is accomplished by, for example, regulated degradation via the ubiquitin proteasome system or by autophagy. Autophagy has been shown to modulate synaptic vesicle numbers and neurotransmission, yet its exact role in the regulation of synaptic function is poorly understood. The proposed project aims at the dissection of the role of autophagy in synaptic protein turnover. Using combined genetic, biochemical, molecular and cellular biology approaches as well as cutting-edge imaging in neurons I will identify presynaptic proteins that are regulated by autophagy and will define the contribution of autophagy to synapse composition and function. Furthermore, I will determine which mechanisms underlie the selective targeting of presynaptic proteins to the autophagy pathway. Taken together these studies will contribute fundamental knowledge about autophagy in neurons and will provide new insights for understanding how autophagy contributes to synaptic plasticity and protein degradation in health and disease.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FORSCHUNGSVERBUND BERLIN E.V.;DE;;; 195088;655297;STOPAPCG1IMP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spatial-temporal regulation of APC/C, its role on G1 arrest and impact on terminal differentiation;1/09/2015;31/08/2017;;Coupling the cell-autonomous process of the cell cycle with spatiotemporal clues that promote the differentiation process is a major challenge in developmental biology. The retina aberrant in pattern (rap) gene was initially identified as a retina differentiation and patterning gene in Drosophila. It was later discovered to encode Fizzy-related (Fzr), a coactivator of the cell cycle regulator, Anaphase Promoting Complex/Cyclosome (APC/C). This was a critical initial step towards establishing a link between differentiation and cell cycle regulation. This project aims to understand the coordination between mechanisms of proliferation and differentiation, with a particular focus on the APC/C complex. The requirement of individual APC/C components to sustain the developmentally controlled G1 arrest and its subsequent effects on terminal differentiation will be addressed. The transcriptional and posttranslational regulation of each APC/C component will be assayed during eye development. Next, functional APC/C interactors will be identified through two complementary screens. An in vivo gain-of-function overexpresion screen will be performed, to identify the genes that can induce cell cycle arrest in overproliferating tissues, using the newly developed FlyORF library. Additionally, a proteomic analysis of APC/C components will be performed to identify eye-specific APC/C interactors. With the information gained I will investigate how the activity and expression of the APC/C is spatial-temporally controlled by signalling cascades during eye development, and how the APC/C in turn modulates the activation and output of those signalling pathways. Overall, the insights from this project will contribute to our understanding of complex diseases such as cancer and neurodegeneration.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195179;655852;Quokka Maturation;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A mature Quokka for everyone advancing the capabilities and accessibility of numerical solar cell simulations;1/02/2016;31/01/2018;;"This project is placed in the field of photovoltaics (PV), which is on the eve of competing with conventional electricity generation on a purely economic basis, and is able to effectively tackle ecologic and socio-economic problems caused by the existing energy system based on fossil fuels.
It aims to help accelerating the R&D efforts into silicon solar cells, the dominating PV technology with a persistent market share of around 90%. Basis for this forms Quokka, a multidimensional silicon solar cell simulation tool recently developed by the applicant. Quokka is specifically designed for silicon solar cell conditions, which allows for valid simplifications to the general semiconductor modelling approaches, and sets it apart from generally more powerful commercial software and other free tools in terms of computational speed and ease of setup. Since its release for free early 2013, Quokka sees a rapid increase of usage amongst all major PV research institutes and manufacturers.
Within this project, the applicant will grow Quokka from its (capable) childhood to a mature simulation tool, being supported by the world-leading expertise in solar cells of the host institution, Fraunhofer ISE. One measure consists in coding optimized numeric routines to efficiently handle much larger mesh sizes, e.g. enabling the unprecedented and very useful capability of simulating a full size silicon solar cell. Furthermore, several physical models of highest future relevance will be identified, experimentally validated and added to Quokkas capabilities. Accessibility to PV scientists, engineers and students in Europe and worldwide forms a key point of this project, and will be achieved by publishing underlying algorithms and validation cases, and by continued free hosting, integration and documentation on the leading web-portal for solar cell modeling.
This project will establish nothing less than the new standard for silicon solar cell simulation tasks, accessible for everyone.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;;; 195186;655881;LIB-Si anode;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Silicon/Carbon Nano-Hybrid Lithium-Ion Battery Anode: Green Facile Scalable Synthesis Inspired by Thermosetting Polymers;14/09/2015;13/09/2017;;The last two decades have witnessed a great commercial success of lithium ion battery (LIB) in portable electronic devices and electric vehicles. However, current LIB technology cannot meet the rapid increasing demand from information technology and vehicle industry, primarily due to limited capacity and serious safety concern of graphite anode. Discovering new anode material with high capacity and good reliability has been a central issue. Because of its high theoretical capacity and excellent operation safety, silicon (Si) has attracted considerable attention as a promising anode to replace graphite. Nevertheless, dramatic volumetric change during lithiation/delithiation process causes severe pulverization and disconnection of electrode from current collector, leading to a fast capacity loss. To tackle these critical problems, a new concept to achieve facile, cost effective, green, and scalable synthesis of Si/carbon nanohybrid anode is proposed. By reducing Si particle size to the range below 10 nm and homogeneous embedding of Si nanoparticles into carbon buffer matrix, the volume change and associated stress can be effectively accommodated to improve the cyclability of the LIBs. Instead of conventional aqueous and/or organic solvents, three industrially widely used thermosetting resin monomer systems including vinyl ester resin, epoxy resin, and phenolic-formaldehyde resin are utilized as both solvent and carbon source. Cost effective silane coupling agents bearing appropriate chemical functional groups act as the precursor of Si and cross-linking agents of the thermosetting polymers. Ultra small Si nanoparticles are in situ formed and homogeneously embedded in the in situ formed porous carbon matrix by sequential photo/thermally induced polymerization, calcination in inert atmosphere, Magnesium thermal reduction, and KOH activation. The mechanism of control over morphology, crystallinity, dispersion, and composition of the Si/C nanohybrid anode and correspondin;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195055;655142;CONSORT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Controlled Singlet Oxygen Release Photosensitizers in Photodynamic Therapy;15/09/2015;14/09/2017;;Photodynamic therapy is a form of phototherapy which uses light-sensitive compounds (photosensitizers) that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells. The photosensitizer creates a highly reactive singlet oxygen species which rapidly reacts with any nearby biomolecules leading to destructive reactions resulting in cell death through apoptosis or necrosis. However, prolonged exposure of tissue to light irradiation causes photosensitivity in patients skin. Side effects may include, pain, burning/stinging sensation, itchiness. This proposal aims to develop a conceptually new approach towards photodynamic therapy through an introduction of new type of photosensitizers and corresponding nanomaterials which are capable to generate singlet oxygen upon irradiation, store it by means of binding to special molecular subunits and slowly release singlet oxygen within tissue on a timescale from several hours to several days after light irradiation treatment. The application of such novel material will allow for increasing therapeutic effect and reduced side-effects with respect to conventional PDT due to shorter light treatment duration. Proof of concept will be attained by demonstration of delayed singlet oxygen formation in cancer cells after the light treatment using in vitro models. The project builds on the strengths of the applicant in organic chemistry, photophysics and material science and combines these with new training in biomedicine and drug development to open a new research direction and to enhance cross-European collaboration.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;IE;;; 195155;655694;GETAGRIP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolutionary Trends And GRasping form and function In Primates and other tetrapod lineages;18/01/2016;17/01/2018;;Human beings have been credited with unparalleled capabilities for digital prehension grasping. However, given the single evolutionary origin of humans and the unique anatomical features they possess, quantitative tests of evolutionary scenarios remain difficult. Moreover, functional inferences based on fragmentary fossil material are often problematic. However, grasping behavior is widespread among tetrapods, thus providing an excellent context for testing hypotheses concerning the origin of manipulation and grasping. The propensity to grasp, and the anatomical characteristics that underlie it, appear in all of the major groups of tetrapods. Although some features are common to all tetrapods, other features, such as opposable digits and tendon morphology, appear to have evolved independently in many lineages. Although recent papers have reviewed the state of the art on grasping, a holistic study including the whole forelimb and its behavioral context in locomotion and manipulation is currently lacking. The goal of the present project is to provide an integrative approach that examines the occurrence of grasping behavior, the anatomy and function of the forelimb, and the evolution of grasping across the three major tetrapod clades that show manual grasping abilities: mammals, reptiles, and amphibians. Within each clade I will compare and contrast the use of the forelimb, its anatomy, and its function in both arboreal and terrestrial animals to test the hypothesis of an arboreal origin of grasping and manipulation capacity. I will study the use of the hand and the forelimb in the context of locomotion and object/food manipulation to understand the relations between anatomy, function and ecology. To do so, I will use state-of-the-art approaches to quantify the anatomy (CT scanning, 3D geometric morphometrics), the function (pressure and force measurements, 3D kinematics and biomechanical models), and the evolution of these traits in an explicit phylogenetic context.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;MUSEUM NATIONAL D'HISTOIRE NATURELLE;FR;;; 195383;657041;GLOBE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;All Organic Redox Flow Batteries;1/09/2015;31/08/2017;;"European Union (EU) intends to significantly reduce the CO2 emissions in the following decades. To do this, the use of fossil fuels in all sectors and particularly in power sector will be continuously reduced and replaced with renewable energy sources. Such transition depends on proper electrical energy storage (EES) technology for renewable energy management in order to handle the varying solar and wind generated electricity. So far only redox flow batteries (RFB) show potential for renewable energy management because of: i) scalability between storage capacity and power; ii) short response time; iii) good cycling capability, iv) long discharge time and v) low cost potential. The use of state-of-the-art metal based RFBs is limited by their relatively high costs that inherently are linked to the low current and energy density. Recently a breakthrough in RFB technology is reported, high current densities are achieved in a RFB based on organic-halide electrolytes. Organic-halide RFB can store electricity at almost ten times lower life cycle cost compared to metal based RFB, due to increased current density and lower electrolyte costs. One of the objectives of the current proposal is to investigate feasibility and stability of organic-halide RFB. The main goal of the fellowship is to build All Organic RFB by replacing the halide part (Br2) with less hazardous and cheap organic electrolytes which have extremely fast electrokinetics: (2,2,6,6-Tetramethylpiperidin-1-yl)oxy (TEMPO) and hydroxylated anthraquinone di-sulphonic acids. Since latter are not commercially available, a new chemical synthesis routes will be developed. Nanoporous films and anion exchange membranes will be considered as an alternative to expensive proton conductive membrane-Nafion. All Organic RFBs show great potential for low cost EES and could facilitate EU transition to low carbon emission/renewable energy based economy.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AARHUS UNIVERSITET;DK;;; 195423;657270;EpiSil-IBC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Epitaxial silicon foil solar cells with interdigitated back contacts;1/11/2015;31/10/2017;;The leading technology in the photovoltaic market today is the single junction crystalline silicon (c-Si) solar cell. Since there is little room for further improvement beyond current efficiency records and to reduce material costs, the industry trend in c-Si technology is pushing towards thinner and thinner cells, which are harder to handle without breaking. The aim of this proposal is to realize a solar cell based on ultra-thin (<50 m) silicon foils with contacts on the back side of the cell. New processing techniques are required in which the foils are bonded to a glass substrate, such that they are never handled free-standing. The goal of this innovative solar cell is to surpass the current state-of-the art efficiencies of thin silicon foil solar cells by using, low-cost and high yield processing.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;;; 195121;655502;CARDI-ACHE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The cardiovascular consequences of endurance exercise;1/06/2015;31/05/2017;;"Problem: Exercise training represents an attractive and low-cost strategy to improve cardiovascular health. Recent studies, however, report novel evidence that endurance exercise can lead to potentially detrimental cardiac maladaptations. First, acute exercise-induced elevations in cardiac troponin (cTn) levels have been found, which typically reflect myocardial (micro-)damage and are predictive of future cardiovascular events and mortality. Secondly, myocardial fibrosis has been reported in 1250% of individuals engaged in lifelong exercise training, reflecting scarring of cardiac tissue that is typically found in patients with cardiovascular diseases (CVD). These cardiac maladaptations are highly unexpected and largely unexplained in apparently healthy individuals.

CARDI-ACHE: Based on the latest scientific insights, the overall aim of this proposal is to elucidate the clinical importance of exercise-induced cTn elevations and myocardial fibrosis in endurance athletes. Better understanding of the clinical relevance of these adaptations is important to differentiate between the beneficial and the potentially harmful effects of exercise. Accordingly, I will study the following scientifically and clinically relevant questions:
I. What is the prognostic value of exercise-induced cTn elevations?
II. What are the functional consequences of myocardial fibrosis and are these mediated by lifelong physical activity?
III. Do exercise-induced cTn elevations contribute to the development of myocardial fibrosis?

Relevance for science & candidate. With this project, I will use the most technologically advanced approaches and tools to understand the clinical relevance of potential cardiac maladaptations to exercise training. The studies are performed in a world-renowned research group which allows me to expand my expertise in exercise cardiology using state-of-the-art facilities.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Liverpool John Moores University;UK;;; 195242;656294;APGAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Air Pollution, Growing brAin and cognitive disordeR in children;15/10/2015;14/10/2017;;Air pollution exposure has been associated with adverse effects on cognition in children. However, the impact of air pollution on the structures and functions of the growing brain in children is unknown. The objectives of the APGAR project are to determine 1) the impact of urban air pollution on the structures and functions of the growing brain in children from the general population, 2) to what extent these structural and functional changes are associated with cognitive performance in children. The APGAR project is a longitudinal study conducted in 400 school age children from the general population, recruited between 2012 and 2013, in different schools in Barcelona, Spain. Psychometric and air pollution measurements were conducted weekly during 2 six-week periods: at the beginning of the school year and 9 months later. Neuroimaging (High-resolution 3-dimensional Magnetic Resonance Imaging (MRI), Diffusion Tensor Images, Fluid Attenuation Inversion Recovery, T2-weighted spin-echo sequences and functional MRI, spectrometry) were also conducted. Interfacing neuroimaging and environmental epidemiology represents an innovative applications of neuroimaging in general population, as previous studies have focused exclusively on effects based on test scores. Using original statistical methods (combination of supervised machine learning methods, feature selection and regression models), we will examine the impact of air pollution on the brain structures correlated with cognitive performance in children. Secondly, we will examine whether profiles of brain changes, specifically related to air pollution exposure, are associated with cognition level in participants. This multidisciplinary project may improve our understanding of the mechanisms that underlie the link between air pollution and cognitive disorder in children, and may lead to public health actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA;ES;;; 195124;655516;Bump-BET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bump and Hole approach to elucidate function of individual bromodomains of BET proteins;1/10/2015;30/09/2017;;Small molecules can be used to probe for biological function of individual proteins. Achieving high selectivity with small molecules against structurally similar paralogues is a challenging task that makes it difficult to characterize function of individual member in the same protein family or individual domain in protein containing multiple target domains. The Bromo and Extra-Terminal (BET) proteins play important roles in transcriptional regulation by controlling networks of genes involved in cellular proliferation and cell cycle regulation. Key to the functions of BET proteins is a pair of highly homologous bromodomains (BD) in tandem, which bind and recognize histone acetylation on its tail. Elucidation of the process controlled by BET proteins would benefit greatly from chemical probes that perturb individual BD with high selectivity. Development of small molecules, including clinical candidate drug I-BET, builds a foundation for us to utilize this chemical probe approach, however lack of selectivity of I-BET against individual BD renders it inapplicable to serve as a chemical probe for individual protein or domain. Recently, we had demonstrated the feasibility of a bump-and-hole approach to engineer BD of BET proteins and I-BET molecule to achieve high selectivity. Here we propose to enhance the selectivity of BD and I-BET derivative pair to apply this technology and to probe for the function of individual BD in a cell-based model. Interaction between modified I-BET and selected BD variant, which retain its histone binding functionality, will be further optimized to achieve >100 fold selectivity against all wildtype BD. After that, a cell-based model will be built to substitute endogenous BET protein with exogenous BET containing BD variant. The ultimate goal is to develop a general chemical biology tool to elucidate the role of any individual BD-containing proteins by targeting specifically the engineered BD without affecting any other BD.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Dundee;UK;;; 195164;655748;BIBLACE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Bible and the Law in Carolingian Europe: Scriptural Exegesis and Royal Legislation from Charlemagne to Charles the Bald (ca. AD 780-880);1/03/2016;31/08/2017;;"In what ways did the Bible shape the formation of political communities in early medieval Europe? This project studies the impact of biblical models on royal legislation in the Carolingian period (ca. AD 780-880). It proposes a new approach to the study of the intersection between religion and politics in a formative period of European history, during which crucial institutional and conceptual resources for the development of political and religious community, statehood and law were created. Under the Carolingian rulers from Charlemagne onwards, we can observe a steady increase of biblical quotations in legal texts issued by the ruler or by assemblies of lay and clerical advisers (so-called royal capitularies and conciliar decrees). Biblical prescriptions and prohibitions were either directly integrated into legal norms or used to justify the establishment or modification of norms. To understand this convergence between biblical law and royal legislation, the rich material of Carolingian biblical exegesis is of crucial importance, since it provides access to the concepts and interpretative traditions associated with specific biblical texts in the minds of contemporaries. Authors and readers of exegetical commentaries were often at the same time advisers to kings and important political decision makers, and also involved in the drafting of legislative texts. The project thus proposes a comparative study of legal and exegetical texts and of their dynamic relationship. It has a twofold objective: first, to analyse the concrete impact of biblical models upon Carolingian society, and the ways in which they were used to (re)define its legal and moral framework; second, to understand the social life of Carolingian biblical commentaries, both as a spiritual and intellectual endeavour and as a social and political practice.";119595,6;119595,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FREIE UNIVERSITAET BERLIN;DE;;; 195106;655421;HYDIN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Experimental constraints on indium transport in hydrothermal systems;1/02/2016;31/01/2018;;Indium (In) is an element that has recently gained great economic importance due to its application in strategic energy and information technologies. Future In shortages projected by the EC Joint Research Council are due to insufficient exploration for In, reflecting the poor understanding of the hydrothermal ore-forming processes that result in economic enrichment of In. Key questions are the relative importance of different geologically relevant ligands for hydrothermal In complexation, the role of anomalously metal-rich fluids, and the efficiency of different ore-deposition mechanisms for formation of economic deposits. The proposed Marie Curie action will address the hydrothermal transport of In through an integrated approach that links high-temperature experimental studies of the solubility and complexation of In with reconnaissance fluid inclusion studies of In deposits and geochemical modeling of ore-forming processes. The experimental research will combine solubility studies at 100-250C with hydrothermal diamond-anvil cell experiments up to 600 and synchrotron X-ray spectroscopy. Based on the experimental results, thermodynamic data for the most important In complexes will be derived. The thermodynamic dataset will be used for modeling the control of key fluid parameters such as temperature, pressure and pH on the transport behavior of In in hydrothermal systems. The modeled data will be compared with In concentrations in fluid inclusions from hydrothermal In ore deposits, which will be determined by LA-ICPMS microanalysis. The outcome will be a quantitative understanding of the ore-forming processes that control transport and deposition of In in hydrothermal systems. The researcher will be part of a research network that will bring together scientists from diverse fields of geosciences and physics. This will create an exceptional training environment and will result in optimum transfer of research expertise and knowledge.;179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 195408;657211;TEMPI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Time of Early Metalwork in Prehistoric Italy;1/09/2015;31/08/2017;;"The researcher is moving from Italy to the UK in order to build a new chronology and classification method for early metal artefacts (i.e. axes, daggers and halberds) from Italy, c.4500-2000 BC. The project aims will be achieved through a combination of radiocarbon dating and scientifically informed work on artefact classification criteria, which takes into account the technological transformation undergone by the objects during their life-cycles. The importance of the project is twofold: (a) this is the first time that a researcher develops a reflexive approach to metalwork classification, which explicitly takes into consideration forging, use and other post-casting alterations to the shape and features of objects; (b) it is also the first attempt ever made to ground the chronology of early Italian metalwork in a comprehensive set of radiocarbon dates. The significance of the project goes beyond Italian archaeology insofar as early Italian metals are typologically cross-linked to similar objects in Europe and the Mediterranean. It is thus anticipated that the project will bring about dramatic changes in our understanding of the chronology and developmental sequence of prehistoric metal technology across large swathes of Europe, with particular reference to central Europe, the western Balkans, Sardinia and Crete. Whilst working on the project, the researcher will acquire new expertise in metalwork use-wear analysis and Neutron Diffraction (ND) analysis, two cutting-edge techniques of artefact characterization. ND analysis will be deployed during a secondment at the ISIS Facility, Rutherford Appleton Laboratory (Didcot, UK). The researcher will also develop new skills in radiocarbon dating, artefact classification and statistical analysis. Newcastle University, the host organisation, will in turn benefit from the researcher's expertise in Italian and European prehistory, with special regard to the technology of prehistoric bronzes.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 195171;655801;EMCOP9CRL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural basis of Cullin-RING ligase regulation by the COP9 signalosome;12/10/2015;11/10/2017;;The components of the Cullin-RING Ligase (CRLs) E3 ubiquitin ligase family play key roles in a wide range of cellular processes including stress response, signal transduction, apoptosis and cell cycle progression, and accordingly, defects in their function and/or regulation are prominent in many pathologies including cancer. The modular CRL architecture is centred upon one of seven different cullin scaffold proteins which associate on one side with a RING protein that acts as receptor for an E2 ligase and, on the opposite side, with a substrate receptor (SR) that confers specificity to the complex. The multiplicity of SRs allows the recognition of many different substrates by the same CRL catalytic core. CRL-mediated ubiquitination modulates the substrates biological activity and in many cases targets them for proteasomal degradation. The COP9 signalosome (CSN) complex plays a fundamental role in CRL regulation both by forming stable inhibitory complexes with the CRLs where the E2 ligase and substrate binding sites are occluded, and by enzymatically removing Nedd8 (a homologue of ubiquitin) from the cullin scaffold subunit, in a process termed deneddylation, that leads to inactivation of CRLs. CRL regulation by CSN is still an incompletely understood topic mostly because of the lack of high resolution CSN/CRL structures due to the challenge that the crystallization of multi-protein assemblies of such complexity represents. Fortunately, recent technological developments in another structural technique, cryoelectron microscopy, now allow structure determination of relatively small protein complexes (< 500kDa) to near-atomic resolution. Hence, we propose to use this powerful technique to reveal very high-resolution structures of several different CSN/CRL holocomplexes and shed light on the mechanistic aspects of their function.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTE OF CANCER RESEARCH - ROYAL CANCER HOSPITAL;UK;;; 195040;655039;NANOSOLAR;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;HYBRID QUANTUM-DOT/TWO-DIMENSIONAL MATERIALS PHOTOVOLTAIC CELLS;2/06/2015;1/06/2017;;The development of high-efficiency and low-cost solar cells is one of the most crucial challenges to secure a clean and sustainable energy source. The novel and tunable optoelectronic properties of nanomaterials are a very promising but still challenging route to achieve this goal. In this project, we propose to combine the advantages of two important nanoscale materials, semiconductor quantum dots (QD) and two-dimensional atomic layered (2-D) materials, to realize high-efficiency hybrid solar cells. Quantum dots are one of the best absorbing and carrier photogenerators due to multiple exciton generation and their size-tunable and direct band gap, however, their poor dot-to-dot conductivity has been a major limitation for photovoltaic devices. We propose to overcome this limitation by intercalating 2-D materials that have shown high charge mobility and strong optoelectronic properties. We propose a tandem configuration based on a stack of QD layers for strong carrier photogeneration, with intercalated 2-D atomic layers for efficient charge and photocurrent extraction. We will study the charge transfer and separation at the interface of QDs and 2-D layers, both of which are strongly affected by quantum confinement. The co-supervisors of this project, Prof. Konstantatos and Prof. Koppens at ICFO, have demonstrated a QD/2-D(graphene) phototransistor with a photoresponse up to 5 orders of magnitude higher than phototransistors based on single graphene or MoS2 atomic layers without QDs, showing the potential of QD/2-D hybrid devices for photovoltaics. In addition to QDs, we will also use small band gap materials, such as phosphorene and other 2-D semiconductors that can harvest energy from infrared hot sources in dark conditions. The proposed hybrid QD/2-D solar cell architecture can have a strong technological impact since both materials can be produced in large scale by chemical synthesis and surpass the performance of current photovoltaic technologies.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 195191;655921;BURIAL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Forming Idendities in a Transitional Area;1/09/2015;31/08/2017;;"For the most parts of the Southeast Europe the awareness of the group identification is to the present day strongly connected with the dominant collective identity of ethnic group as a persistent and impenetrable community with cultural and biological continuity within certain territory. This, for obvious reasons, hazardous concept was consequently adopted also for the non-written societies in the past by using their material culture, foremost burials and specific grave belongings (jewellery, weapons), as a prime source of the distinction.
In contrast to this unilateral and static model of ancient societies, the archaeological remains from the new investigated cemetery Dolina in Croatia as well as from neighbouring sites in Bosnia are providing different and innovative approach to the questions of identity. Large diversity of the burial customs and funeral objects are indicating that group identification needs rather to be understood as overlapping, multifaceted and dynamic construct.
Within the scope of the proposed programme the detailed analysis and interpretation of the archaeological features will be supplemented with the input from cultural anthropology and natural science methods (geomagnetic, radiocarbon dating, petrography and chemical analysis of pottery and bronze objects). The multidisciplinary approach as well as collaboration with the experts of the host institute OREA in Vienna will provide optimal evaluation of data and gain a unique insight into the structure of the ancient communities, their identity expression and group identification in general.";178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN;AT;;; 195368;656988;NEDBELS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;NEURODIVERSITY BETWEEN LAW AND SCIENCE;1/09/2015;31/08/2018;;The aim of the research proposal Neurodiversity between Law and Science (NEDBELS) is to inquire into the legal impacts and socio-political implications of the concept of neurodiversity. This term pertains to individuals diagnosed with neurodevelopmental disorders such as Aspergers Syndrome and Autism and hypothesizes the emergence of a new category of difference in the human population. NEDBELS explores how this concept challenges the constitutional principle of equality, as well as how it fosters the need to accommodate new principles in criminal and civil law. This proposal has risen from a need for heightened communication between law and science. Scientific theories, concepts and methods widely permeate law and adjudication, and legal and ethical frameworks intimately drive applied sciences, as in education and health care systems. Therefore, one might reasonably expect that these two worlds would cooperate on a regular basis. However, lawyers, scientists and health care professionals operate largely insulated from one another in research, formal training and daily practice. This divergence prevents vulnerable minorities, such as people with neurodevelopmental disorders, from reaping the full socio-political potential of scientific advancements. NEDBELSs goal is to increase communication between law and neurosciences through interdisciplinary research methodologies and scientific training-through-research as well as by enhancing the synergy among legal experts, policy makers and scientists in the field of neurodiversity;159034,56;159034,56;H2020-MSCA-IF-2014;MSCA-IF-GF;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;IT;;; 195140;655605;STOP-Beta;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Selectively Targeting Oscillations in Parkinson's disease: Causal effects of the beta-rhythm on motor control;1/05/2015;30/04/2017;;"Parkinsons disease is a frequent and disabling neurological disorder, which heavily impairs patients ability to perform and control movements. Electrical stimulation of a deep-seated brain region, the subthalamic nucleus (STN), has been shown to significantly improve patients motor function and quality of life. Recent technological advances in deep brain stimulation (DBS) render it possible to adjust electrical stimulation of the STN to ongoing brain activity, referred to as closed-loop DBS. Here, the implanted electrodes do not only send signals to the brain but also read out neural signals generated by the brain. Closed-loop DBS offers the intriguing possibility to specifically suppress pathological brain activity while leaving physiological activity unaltered.
We propose an innovative and ambitious project, which the researcher will conduct in the Experimental Neurology group headed by Prof. Peter Brown at the University of Oxford, a world-leading laboratory in closed-loop stimulation. In this project we aim to test the hypothesis that closed-loop DBS that selectively targets pathological synchronous firing of neurons at 13 30 Hz, the so-called beta-rhythm, will interrupt neural activity related to motor impairment, but not normal functions of the brain. To this end, Parkinson patients with implanted electrodes in the STN will perform two tasks probing different aspects of motor control whilst receiving closed loop stimulation. We will simultaneously record activity from the STN and areas localized on the surface of the brain. This will allow us to assess how suppression of the beta-rhythm affects motor-related activity and connectivity in the human brain revealing its causal effects on motor function. Selective suppression of abnormal brain function and preservation of physiological brain mechanisms could be the key to obtain the best possible clinical benefit, whilst avoiding unwanted side effects in the treatment of Parkinsons disease.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195207;656205;MONASPOWER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Monasteries as Institutional Powers in Late Antique and Early Islamic Egypt: Evidence from Neglected Coptic Sources;1/04/2016;31/03/2018;;"Egypt during the Late Antique and Early Islamic periods (broadly the 5th to 8th centuries CE) was a multicultural and multilingual country. Greeks, Egyptians, and, later, Arabs populated the land, speaking Greek, Coptic (the last form of the indigenous Egyptian language), and Arabic. Before the Arabic conquest of 640-642 CE, Christianity was the predominant religion of Egypt, and continued to be so for a while after the conquest, until the 8th and 9th centuries when conversion became more widespread. Centuries of co-existence brought Greeks into contact with Egyptians and vice versa, yet the picture of Late Antique Egypt is a largely Greek one: Greek was the official language of the administration and the majority of Greek non-literary textual finds from this period are also in Greek. As a result, studies on life and especially the economy have focussed on the evidence written in Greek. This study does not seek to study the complex social, cultural, linguistic, and religious interactions at play in the country during this time. Instead, it will provide a new perspective on the economic landscape of Egypt.

Monasteries had been a significant part of the Egyptian landscape since the beginnings of Christianity in the country. Life inside these institutions was recorded primarily in Coptic. Despite the importance of monasticism and the body of available Coptic texts, their position within the Egyptian administrative and economic framework has largely been ignored, with attention placed instead on the contemporary large Greek estates. The aim of this project is to study the economic position of Coptic monasteries during this timeframe on the basis of the neglected evidence from two sources: the monastery of Apa Thomas at Wadi Sarga and the corpus of non-literary Coptic texts in the collection of the University of Copenhagen.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KOBENHAVNS UNIVERSITET;DK;;; 195227;656070;PLACAV;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Polarized light as an alternative to colour in animal vision;1/03/2015;28/02/2017;;"Imagine life without colour. Many of the rich layers of information in our visual world would disappear and simple tasks, such as finding a red apple in a tree, would be far more difficult. There are many examples of animals in nature that have limited colour vision, yet some have managed to develop high-performance eyes that, in some respects, far surpass our own visual capabilities. One of the ways that animals have achieved this is to make use of the polarization of light rather than colour. The reasons behind this are not understood and represent a novel area for scientific exploration.

Many animals have been shown to be sensitive to the polarization of light, but nearly all research to date has focussed on dedicated eye structures for detecting specific cues such as the polarized sky field for navigation (e.g. in honey bees, ants, and locusts). The recent discovery that some animals make use of a highly developed sensitivity to polarized light across the whole visual field of their image-forming eyes opens the way for new investigations into the use of polarized light for object detection and discrimination, a field previously dominated by the study of colour and intensity visual systems.

I have shown in recent investigations that fiddler crabs have highly-acute sensitivity to polarized light across their whole visual field. These animals have been model species for behavioural ecology research over the past 50 years and so represent an ideal organism for developing a clear understanding of image-based polarization vision. The central question of what has caused evolution, in the case of fiddler crabs, to develop high performance polarization vision rather than colour vision will be addressed at both the physiological and behavioural levels by asking the following two broad questions:
Q1 How is polarized light information processed in the nervous system of fiddler crabs?
Q2 How do fiddler crabs use polarized light information in their natural environment?";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITY OF BRISTOL;UK;;; 195073;655232;ReprObesity;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Overweight-induced Hypogonadism as major factor for the generation and/or perpetuation of Metabolic Co-morbidities of Obesity: Contribution of Epigenetic Regulatory Mechanisms;1/10/2016;30/09/2018;;Obesity is a global health problem whose prevalence is increasing substantially due to lifestyle changes. This complex medical condition is frequently linked to serious metabolic complications and deregulation of hormonal axes, which lead to perturbed homeostasis in conditions of overweight. Different studies have suggested that obesity is often associated to hypogonadism, a reproductive disorder that might also promote metabolic alterations, thus setting a vicious circle in the generation/perpetuation of obesity co-morbidities. While the targets and molecular mechanisms underlying this phenomenon are still unknown, emerging evidence from experimental models of metabolic stress linked to hypogonadism strongly suggests the potential role of perturbations of hypothalamic Kiss1/NKB neurons. Likewise, the recently identified involvement of epigenetics in the control of Kiss1 expression at puberty, a crucial stage in sexual development that is metabolically gated, suggests also the contribution of these regulatory mechanisms to this phenomenon. In this context, this project aims to elucidate the pathophysiological relevance of epigenetic regulatory mechanisms in obesity-induced hypogonadism and their influence in the generation/ maintenance of the metabolic complications of overweight. To this end, we will characterize the time-course of alterations of key hormonal and epigenetic factors in preclinical models of obesity and will evaluate the contribution of epigenetic modifications in deregulation of hypothalamic Kiss1/NKB neurons in conditions of overweight. In addition, we will analyse the potential role of gonadal steroids in this phenomenon. This project will help to identify the molecular targets and epigenetic mechanisms responsible for the metabolic perturbations linked to obesity-induced hypogonadism, and will aid to define better tools for the treatment of these complications.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSIDAD DE CORDOBA;ES;;; 195234;656244;ARSENICLOSS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Chemical and metallurgical aspects of arsenical bronze: the case of arsenic-loss in prehistoric metal production;6/07/2015;5/07/2017;;"The main goal of this project is to investigate out-of-equilibrium Cu-As alloys, i.e. 0-10 wt.% As in the range used in the transition period between Stone and Metal ages. The research protocol is made of several steps: equilibrium and out-of-equilibrium phase diagrams in the above mentioned range, evaluation of mechanical properties of Cu-As alloys in the most common metallurgical states (as-cast, annealed, cold-hardened, recrystallized), and estimation of the loss of As during metallurgical transformations (melting/casting, homogenisation and recrystallisation annealing) according to the number of iterations and of the treatment temperature and dwell time. The fulfilment of these objectives is of high importance for materials science applied to archaeology dealing with development and usage of this very first alloy produced by human kind.
The applicant will acquire and share with the scientific community new knowledge in the production, thermomechanical treatment and consequent properties of the misknown arsenical bronzes. She will use her metallurgical experience and archaeological knowledge (both matured in the field of tin-bronzes) applied to production, treatment and analyses of arsenical bronze. The additional knowledge the applicant will obtain within the project is related to the domain of phase diagrams creation and the usage of DTA, DSC and XRPD, under the supervision of experienced researchers from inorganic chemistry and metallurgy.
The project as a whole will provide for the first time:
1) out-of-equilibrium phase diagrams for the Cu-As system
2) determination of chemical, physical and mechanical properties of arsenical bronze in the range of 0-10 wt.% arsenic
3) a comprehensive overview on the actual loss of arsenic during metallurgical transformations.
The proposed project constitutes an excellent career-springboard for the applicant, being then the sole expert on the usage of arsenical bronze in the field of European archaeometallurgy.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE MICHEL DE MONTAIGNE- BORDEAUX 3;FR;;; 195109;655429;PoetEleg;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Aestheticization of Life and Cosmopolitan Modernity: The Poetics of Elegance in the Long 19th Century;1/03/2016;28/02/2018;;In the course of the long 19C the pursuit of 'elegance' emerged as a phenomenon aiming at an intensification of life through aestheticization. The distinguishing features of an 'elegant' appearance manifested themselves in the self-fashioning of an individual person (language, attire, behaviour) and in the shaping of domestic and public environments (artefacts, interior design, architecture). The concept of elegance was realized in social action and cultural practices, particularly in convivial conversation, entertainment and leisure activities. The project demonstrates that one of the crucial patterns of modernity manifests itself in the phenomenon of elegance, which inaugurates a specific aesthetic of the surface as a distinguishing social feature as well as a marker transcending the established order: an imaginary community of urban origin that supersedes historically conditioned social and gender norms. Committed to the methods of transnational historiography, the study outlines the European topography of the so-called elegant world in the tension between national aspirations and transnational aesthetic norms. The project focuses on circulating things and examines the social agency of press and material goods. It pays particular attention to an innovative type of cultural journals, which reported in detail on urban social, cultural, and material life and helped spread the new urban styles of living and had a decisive impact on the staging of a new, imaginary cross-border community. Its geographic range is marked by the imperial metropolises, as well as by aspiring Central and Eastern European cities such as Berlin and Leipzig, Prague and Pest, which developed into new urban centres in the course of the 19C. The main output of the project is a monograph that maps out the phenomenon of elegance and the way it redefined the social order, constituted urban life, and expressed the transnational aspirations and affiliations of the elite.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195149;655660;HYBRIPORE;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hybrid DNA-protein nanopores with large and uniform pore sizes;1/07/2015;30/06/2017;;This proposal aims at developing novel hybrid DNA-protein nanopores with well-defined, uniform channel sizes, to advance fundamental studies on transport across membranes and to enable the development of new biosensors and progress towards creating artificial cells and tissues. Currently used protein nanopores either have a limited cargo capacity, which is set by their internal diameter, or they are heterogeneous in size and sometimes incompletely assembled. I propose to use DNA origami nanostructures as scaffolds for barrel- and ring-forming peptides of alpha-haemolysin and ClyA/Wza to create hybrid pores with larger and uniform pore sizes. These hybrid pores have the advantage that they are fully biocompatible and retain the potential for genetic and chemical engineering at the level of the DNA and proteins through the use of nucleotide recognition sequences and functionalised amino acid residues. By systematic characterisation of the hybrid nanopores in the controlled environment of droplet interface bilayers using single-channel current recordings and fluorescent detection of transport across membranes, the proposed hybrid nanopores will provide valuable insights into membrane transport and potential applications in biotechnology and medicine.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195217;656081;Turb. Bound. Layers;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Effects of multi-scale rough patches on hydrodynamics and scalar dispersion in turbulent boundary layers;1/05/2015;30/04/2017;;"The objective of the proposed research initiative is to experimentally investigate the effects of irregular multi-scale wall roughness on turbulent boundary layers. It is widely understood that wall roughness has a significant effect on turbulent boundary layers, however the majority of the existing research on this complex mechanism has been limited to homogeneous distributions of roughness covering the entire surface. Current models fall short for the majority of real-world flows that develop over surfaces with natural irregularities such as flows over ship hulls containing barnacles or atmospheric flows over cities or forests.

In this proposed research, a range of experiments will be carried out to investigate the flow around custom-manufactured patches of wall roughness placed within a turbulent boundary layer. Wall roughness elements will be designed using fractal patterns in order to isolate the multi-scale effects of the roughness geometry. Measurements will be performed in a wind tunnel and in a water channel at the University of Southampton (UoS), using a force balance to directly measure the wall friction, particle image velocimetry to measure the local flow structure, and planar-laser-induced fluorescence to measure the local dispersion for a variety of different patch topologies.

This work will further the fundamental understanding of turbulent boundary layer flows and will have practical relevance to environmental, transportation, and energy engineering by setting the groundwork for the understanding and parameterization of multi-scale roughness effects. This ambitious research initiative will be achievable by leveraging the combined expertise of the proposed Fellow in experimental fluid dynamics and turbulent shear flows and the expertise of the UoS in aerodynamics and turbulent boundary layer research.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SOUTHAMPTON;UK;;; 195091;655324;GOFAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Galactic Outflows and Feedback in the Astro-H eR;1/08/2015;31/10/2017;;"Training: The GOFAR proposal is to train the Technion candidate to work on the Soft X-ray Spectrometer (SXS) built by NASAs Goddard Space Flight Center (GSFC), for launch soon on the Japanese space observatory
Astro-H that will be the working horse of X-Ray Astronomy in the next decade. The X-ray Astrophysics Laboratory at GSFC, the world centre for astrophysical X-ray spectroscopy and instrumentation will set up a data analysis facility at the adjacent University of Maryland (UMD), who will host GOFAR. Owing to its unprecedented combination of spectral resolution and sensitivity between 6 7 keV, the SXS will detect and measure, better than ever before, the hottest and most ionized X-ray astrophysical plasmas. GOFAR will thus position the candidate and his Technion group at the forefront of X-ray astrophysical research in the coming decade, but will also improve his project-management skills for the university hardware projects that he leads.

Research: We propose to develop new spectroscopic diagnostics to match the spectral resolving power and sensitivity of the SXS for K- and L- shell ions in both photo- and collisionally- ionized plasmas, focusing on active galactic nuclei (AGN) outflows. We will measure the most ionized components of the winds, implied previously to dominate the outflow mass and energy. We propose to measure the location, mass outflow rate, and kinetic power of the wind, which govern its influence on the host galaxy. This will be the first opportunity to confirm and measure in detail the fastest components of AGN winds that were claimed to reach a fraction of the speed of light (~ 0.1c). Since the kinetic power in the wind scales as the outflow velocity cubed, these components are the most promising AGN energy feedback, and for enriching the intergalactic medium (IGM). We will attempt to identify absorption from filaments of the IGM, which represent the long sought-after missing atoms of the Universe.";198836,1;198836,1;H2020-MSCA-IF-2014;MSCA-IF-GF;TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY;IL;;; 195156;655698;BioMASCE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biophysical Manipulation of Adult Stem Cell Epigenetics (BioMASCE) By Cell-Penetrating Nanoneedle Substrates;1/06/2016;31/05/2018;;Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies. In part, their capacity for multi-lineage differentiation and subsequent therapeutic efficacy is controlled by the epigenetic status of the DNA. The Stevens Group at Imperial College London (ICL) has recently developed a novel material platform of porous silicon (pSi) nanoneedles (nNs) that penetrate the cell membrane, stimulating physical changes in the nucleus. Interestingly, nuclear mechanics and shape parameters have been shown to control epigenetic status in various cell types, but this remains under-investigated in hMSC. Therefore, in the present study, pSi nNs will be used to manipulate hMSC nuclear size and shape, as well as the resulting epigenetic status, as a means to identify novel mechanisms for enhancing differentiation capacity. The inherent porosity of the nNs, coupled with their ability for cell penetration, will be exploited as a delivery tool for a cutting-edge class of non-coding RNAs into hMSCs to interfere with, and further regulate, epigenetic status and resulting therapeutic potential. This discovery-driven project leverages a one-of-a-kind engineering tool for investigating and manipulating hMSC behaviour. In parallel, the applicant has proposed to undergo a secondment to a UK-based, non-academic partner organisation to enhance his knowledge of intellectual property protection, technology development, and product commercialisation in order to translate his research findings for clinical benefit. The applicant will increase his knowledge base during the project, creating new contacts in his personal network, as well as for the Stevens Group and ICL. This project represents a multidisciplinary, cutting-edge approach to stem cell biology and biomedical engineering, utilising cross-sectoral collaboration for enhanced training and potential for industrial translation of basic research findings.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195025;654971;EXPMFSG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Search for an experimental test of the mean-field theory of simple glasses;16/07/2015;15/07/2017;;The goal of this project is to contribute to the design and execution of a precise experimental test of a theory for the glass and jamming transitions. Indeed, the last few years have witnessed a considerable advance in the microscopic description of glassy systems: an intrinsic relation between these two transitions has been uncovered. The phase diagram was obtained, finding that the jamming transition is located inside the glass phase and corresponds to a transition from entropic rigidity to mechanical rigidity. This last year has brought new breakthroughs: the jamming critical exponents can be computed with the theory, which suggests a precise test in a lab. The testing of these new progresses in theory requires an integrated research program joining theory and experiment, an opportunity that is emerging in Paris, by the collaboration of the group of F. Zamponi (supervisor of this action and one of the co-authors of the main last theoretical results) with the nearby experimental group leaded by O. Dauchot. Hereby, I present this project with the aim of being part of this exciting opportunity.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195219;656131;APE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An analyzer for preterm EEG;1/09/2015;31/08/2017;;Compromised early brain development leads to lifelong disabilities, which have a heavy impact on the child, families, as well as society as a whole. Advances in clinical care have led to an increasing number of babies surviving extreme prematurity. The global challenge is to avoid early brain injuries by optimizing neurological care during the early days of neonatal intensive care. This aim necessitates the use of constant, cot-side brain monitoring using the electroencephalograph (EEG), which faces formidable logistic challenges due to the need for large scale data analysis by EEG experts. The only imaginable solution for dealing with the vast amount of EEG information is to automate EEG analysis. This action proposes the development of an original, automated, cot-side Analyser for Preterm EEG (APE). This algorithm will be based on the combination of state of the art biomedical signal processing techniques and recent advances in basic developmental neuroscience. An accurate cot side EEG analyser has strong clinical potential for improving early brain care, leading to lifelong improvements in affected individuals as well as unprecedented opportunities to benchmark new brain interventions. The project will significantly develop the applicants career by adding new domains of human neurophysiology and basic neuroscience, bio-signal analysis, as well as conduct of international research projects to his skillset. His secondment to a well-established Finnish SME in the field, MegaEMG, will provide insight into the development of medical devices, commercialization, and regularity environment. The technology developed in this project is translatable into medical devices, providing an opportunity to enhance Europes status as a market leader in brain monitoring devices, as well as University of Helsinkis standing as a centre of excellence for neonatal neurophysiology.;191325,6;191325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 195058;655153;IgEPath;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;IgEPath - Contributions of IgE-antibodies and IgE effector cells to host defense against pathogenic bacteria;3/08/2015;2/08/2017;;"In combination, Immunoglobulin E antibodies (IgEs) and IgE effector cells, most importantly mast cells (MCs) and basophils, are best known for their disease-causing roles in allergic conditions. MCs can also participate in innate host defense against pathogens and toxins. In contrast, physiologic functions of IgEs that benefit the host are still elusive. Dr. Philipp Starkl led a recent study reporting the critical role of IgEs and IgE effector cells in a beneficial type 2 immune response against bee venom in mice, supporting the idea that allergies represent defense mechanisms against toxins. Toxins that induce IgE development are also produced by various pathogenic bacteria. IgE production during bacterial infection has been considered detrimental since it is associated with the exacerbation of atopic diseases.
This study investigates the hypothesis that toxin-specific IgEs can be important for acquired immunity against pathogenic bacteria by increasing the sensitivity, extent and specificity of the bactericidal MC response.
The main objective of this study is to decipher the roles of IgEs and IgE effector cells in host defense against invasive secondary infections with antibiotic resistant pathogenic bacteria, which are a major health problem in Europe.
The experimental approach facilitates knowledge transfer between the US and EU and complementarily combines the applicants expertise in type 2 immunity, IgEs and MCs (acquired in the US) and Prof. Sylvia Knapps competence in bacterial infections and involves in vivo mouse models of infection in transgenic mouse strains and MC in vitro models.
The secondment in a pharmaceutical company will inspire collaboration and translation of results into vaccine development.
This MSC fellowship will support the applicants career development by fostering acquisition of novel expertise in infectious diseases, collaboration with and reintegration into the European research community and connecting with the industrial sector.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;MEDIZINISCHE UNIVERSITAET WIEN;AT;;; 195125;655524;FDtoQG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;From fluid dynamics to quantum gravity;3/08/2015;2/08/2017;;Reconciling general relativity with quantum physics is the Holy Grail of theoretical physics. Today the major physical predictions involving both gravity and quantum fields, in the framework of quantum field theory in curved space-times, are black hole radiation and particle production in an expanding Universe. These phenomena are the corner stones of our present knowledge about the quantum nature of space-time, and it is of crucial importance to understand deeply their features and consequences in the quest for a quantum theory of gravity. Unfortunately, these features are still poorly understood, and are experimentally out of reach in astrophysics. This project will bring together an experienced researcher with expertise in Hawking radiation and black hole physics, with a world leader physicist in artificial space-times in fluid flows to tackle these questions in the innovative approach of analog gravity. Unlike in astrophysics, artificial black holes can be experimentally realized using fluids, showing both their classical and quantum properties. Because these fluids are well understood, both experimentally and theoretically, many conceptual questions can be explicitly addressed in such systems. By working in a world-leading group in the field at the University of Nottingham, the local expertise and mine will be the perfect match to tackle these questions.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF NOTTINGHAM;UK;;; 195212;656198;TRANSIT;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The daily governance of transit migration in Turkey at European Union borders: The two-way influence of Turkish-European Union border and migration management practices;1/09/2015;31/08/2017;;This project examines the daily governance of transit migration by Turkish political and security professionals at the European Union (EU) borders. It draws upon a sociological approach that focuses on migration and border management practices by Turkish authorities within everyday forms of risk governance. In particular, the research explores the two-way influence of EU and Turkish risk perceptions and risk technologies in relation to transit migration and investigates how such interaction affects daily experiences of migrants and gives way to new intentions, struggles and mobilities. The research applies a triangulated methodology based on genealogy, qualitative interviews and ethnographic research. Data collection will take place at Turkey's two land border crossing points and at one sea border crossing point with the EU as well as in Ankara. Thus, the project is empirically, theoretically and methodologically original and makes a timely intervention into current debates over migration pressures facing the EU from Turkish territories, especially with regard to the increasing number of Syrian refugees in Turkey and ongoing conflicts in the Middle East. The research will take place at the University of Amsterdam under the supervision of Prof. Marieke de Goede, who is an advanced scholar in risk and security governance in Europe. The fellowship will significantly impact on my academic skills through a two-way transfer of knowledge with the host institution that has substantial expertise in critical security studies. It will enhance my career options in finding a tenure-track position in Europe as I will dedicate my time to deepen my academic knowledge, make international, peer-reviewed publications and expand my international network. The research will add to the European research excellence in critical security studies and produce results with the societal impact of raising awareness about Turkey becoming a key country of transit migration and immigration;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195225;656136;NAUTILUS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NEW MODELS FOR MACROPRUDENTIAL POLICY AND FORECASTING: THE EURO CRISIS;1/07/2015;31/12/2016;;As outlined in the Van Rompuy Report (2012), various potential models of monetary and fiscal union for Europe should be investigated and assessed, including different forms of shock-absorption mechanisms. In this context we explore new macroprudential policies for monetary and fiscal consolidation in the EU after the recent financial and sovereign debt crises, also in comparison with other major world economies in order to ensure long-term sustainability and the effective stabilisation of the Eurozone. Novel economic models are introduced and their applicability, forecastability, institutional characteristics and societal impact are evaluated.;129357,9;129357,9;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN UNIVERSITY INSTITUTE;IT;;; 195094;655339;DPETNA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dynamics and Predictability of the ENSO teleconnection to the Tropical North Atlantic;1/06/2015;31/05/2017;;"This proposal aims at exploring the El Nio-Southern Oscillation (ENSO) influence on the tropical North Atlantic (TNA) sea surface temperature (SST). The SST variability in the TNA region has been observed to affect weather and climate in surrounding areas, including European heat waves, tropical Atlantic hurricane activity, the West African monsoon, and rainfall over north-eastern Brazil. Fishery production in the subtropical Atlantic is, likewise, closely related to TNA SST anomalies. Hence, better understanding the predictability sources of the TNA SST variability is of major relevance, not only for the climate forecasting community but also for different socio-economic sectors.

The scientific objective of this project is to advance understanding of the simulation and prediction of TNA SST at seasonal-to-interannual timescales. The main goals are to gain insight into the dynamical mechanisms at work, and to assess the ability of current seasonal forecast systems in representing the ENSO-TNA remote connection. Climate model deficiencies and biases, which lead to uncertainties in their forecasts, will also be addressed. Concrete plans for society outreach, enabling the impact and dissemination of results, will be undertaken in a targeted work-package. The novelties of this project are (i) the evaluation of a new teleconnection mechanism to explain the timing of the intertropical relationship, (ii) the assessment of the ENSO contribution to SST skill over the TNA region, and (iii) the use of the most complete set to date of operational seasonal forecast systems. The latter, in particular, ensures that the outcomes derived from this fellowship will contribute to meet users needs.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;ES;;; 195202;656011;HRPCDMECH;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Investigating how pathogen effector recognition by the host plant activates cell death;1/02/2016;31/01/2018;;Plants are rich sources of nutrients and water for diverse microbial communities. Some of these communities evolved parasitism as a strategy to access plant nutrients, with devastating results for crops. Plants are protected from infection by a waxy cuticular layer above the walls of epidermal cells. Would-be pathogens breaching this barrier, or entering via stomata, encounter an active plant immune system that specifically recognizes pathogens. Breaching leads to the deployment of two synergistic pathways that orchestrate immune responses. The first relies on the detection of pathogen-associated molecular patterns (PAMPs) and culminates in pattern-triggered immunity (PTI). When the first is circumvented a second array of responses takes place known as effector triggered immunity (ETI). In ETI, host factors known as R proteins recognize pathogen effectors, an event which is accompanied by the execution of a unique programmed cell death (PCD) type known as the hypersensitive response (HR). Although the initiator of the HR-PCD is known to depend on the formation of an effector-R complex, the downstream molecular events remain elusive. Previous results showed that particular proteases known as metacaspases (MCs) modulate HR-PCD, highlighting the importance of proteolysis and proteome rearrangements for HR-PCD modulation. I will attempt to shed light on the rearrangements of the HR-PCD proteome landscape, by studying processes that control it: selective RNA decapping and translation and proteolytic events, in a highly temporal manner using systematic approaches and reverse genetics. This project is expected to elucidate the importance of these processes and provide a detailed analysis of mRNA and protein level rearrangements during HR-PCD. In addition, this project will suggest strategies for enhancement of plant immunity against pathogens, which is urgently needed to sustain food security considering the ever growing earths population.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE SAINSBURY LABORATORY;UK;;; 195176;655833;ImagiNE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Imaging Nonlinear Elasticity for seismology;1/09/2016;31/08/2018;;Over the last 10 years, new developed tools such as the ambient noise correlation technique have enabled to detect small and transient change in elasticity due to earthquakes or volcanic activity. There are strong indications that such changes are related to nonlinear elastic processes in the Earth's crust. Indeed, at the laboratory scale, it is observed that dynamic elastic waves (equivalent to an earthquake at large scale) with amplitudes greater than a microstrain will transiently soften the elasticity of rocks. Therefore, we expect that studying nonlinear elastic processes in seismology can help us understand the mechanism of seismic faults, volcanic regions and phenomena such as landslides. Because ambient noise techniques require a long averaging in space and time, only long-term relaxations (called slow dynamics) due to nonlinear effects have been so far observed. However in the laboratory, fast dynamics near damaged zones also exists along with slow dynamics. We will bridge this gap by focusing on active seismicity (no averaging required) at short time scales just before and after main earthquakes (up to ~ few weeks) using dense seismic networks and array processing techniques. By concentrating our efforts to these fast nonlinear effects, we devote this work to our long-term goal of detecting precursors for earthquakes, volcanic eruptions, landslides, etc. The applicant's broad experience in nonlinear elasticity and the internationally renowned expertise at ISTerre both in large-scale seismology and laboratory-scale acoustics make it the ideal combination for this project. We intend to develop novel imaging techniques at the laboratory scale before applying them at various larger scales. The methods developed here can potentially lead to innovative techniques in various other domains, including non-destructive testing of materials, exploration of natural resources and medical imaging.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE JOSEPH FOURIER GRENOBLE 1;FR;;; 195192;655928;Woolvation;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Development of sheep wool blocks to be used for greenhouse cultivation;1/04/2015;30/09/2015;;"The main novelty of Woolvation project is the introduction of an eco-innovative cultivation block for vegetable production in greenhouses that is made from a natural raw material (sheep wool), and being 100% bio-degradable it will have no negative impact on the environment. The introduction of Woolvation blocks means an entirely new application for sheep wool, whose chain-of-use will become 100% sustainable, from farm to farm, or from farm to biogas. The overall Woolvation idea has the ambition to
Give sheep wool a new recovery potential, which will reduce wasted sheep wool to a minimum
Minimise the use of rockwool in greenhouses, which become a hazardous waste after use
Provide a new soil amending product (mixed with manure or pure) to farmers
Provide new feedstock (mixed with manure) for bio-gas plants
To achieve that the aim of this Project is to study the feasibility of the Woolvation idea which will include a
a)technical feasibility tests
b)economic feasibility studies
c)business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;MST-DRAENBEDARF GMBH;DE;;; 195353;656896;MAIDEN-SPRUCE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Tree growth, forest carbon storage and climate change in a Canadian boreal region using a model-data fusion approach;1/10/2015;30/09/2017;;The boreal forest is one of the most important global carbon sinks but its carbon fluxes and total amount of sequestered carbon depend on the regional climate variability. Because of this sensitivity to climate, boreal trees are also important natural archives of current and past climate change. During this project, we will use a data-model approach to improve our understanding of the links between forests and climate in a Canadian boreal region over the last millennium. More specifically, we will adapt the process-based ecophysiological model MAIDENiso to investigate factors influencing the growth and underlying biogeochemical processes of black spruce (Picea mariana (Mill.) B.S.P.), the most representative species of the North American boreal biome. This will give an insight into carbon storage in the taiga and will provide the first multiproxy (ring widths and ?18O and ?13C in tree-ring cellulose) regional climate reconstruction in Eastern North America over the last millennium. MAIDENiso will be calibrated on a recently developed network of tree-ring data from the taiga of Quebec. This project will have important implications. First, we will get information on the capacity of black spruce forests to adapt to climate change and to act as carbon sink using an innovative approach that can be transferred to study European boreal ecosystems as well. Second, we will reduce the uncertainties on the estimates of the climate variability of the last millennium in a region that has historically been under-represented in the Northern Hemisphere network of climate reconstructions (see IPCC AR5). Finally, we will be able to analyze the impact of each climate forcing (volcanism, solar activity, CO2 concentration) on the regional climate and carbon sink variability. An important aspect of this project is its multidisciplinarity. Climatology, geochemistry, dendrochronology, tree physiology and numerical modelling will be used linking together European and Canadian scientists.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE D'AIX MARSEILLE;FR;;; 195393;657118;MIGMED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Migration in the early modern world: the Franciscans of the Custody of the Holy Land as afacilitator of the circulation of people in the Mediterranean;1/09/2016;31/08/2018;;Migration is a key socio-political issue in present-day Europe, however it is by no means a new phenomenon. Even though the importance of South-North (and vice versa) mobility on the development of our society has been addressed by historians, characteristics of this phenomenon have not yet been fully investigated nor have been the similarities between early moderns mobility and our actual experience. Was migration in the early modern world a network driven phenomenon? What is the link between internal migration and long distance mobility? Leaving aside individual experience, how did migration influence the life of communities at large? This research project aims to answer to these questions and to deepen our understanding on migration in the Euro-Mediterranean region during the early modern period. In order to do so it investigates mobility between Palestinian parishes and from Palestine to Europe during the 17th and the 18th century focusing on the Custody of the Holy Land of Jerusalem. By complementing Islamic court records and Ottoman surveys with Franciscan sources and previously unused parish registers, it will shed new light on spatial mobility and will contribute to overcome the limits of current research on the topic. Methodologically, the proposal breaks new ground by combining micro-, meso- and macro-level analysis and conceptualizing the role of the Franciscan order as part of a migration network. The results of in-depth research on numbers, motives and experiences of individuals and groups moving in and around the Holy Land will help to advance the wider fields of migration, mission and parish studies in the Mediterranean.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195076;655239;HAP4MARBLE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Multi-functionalization of hydroxyapatite for restoration and preventive conservation of marble artworks;1/09/2015;31/08/2018;;The HAP4MARBLE Project is aimed at developing a new multi-functional treatment for conservation of marble artworks in Cultural Heritage (CH) and validating it in the field. Marble has been widely used in architecture and sculpture since antiquity, but it is subject to several weathering processes, predicted to be worsened by future climate change. Because not fully satisfying treatment currently exists against these weathering processes, the project will be aimed at multi-functionalizing a recently proposed biomimetic treatment based on hydroxyapatite (HAP), to make it able to tackle all the main marble degradation processes (sugaring, soiling, dissolution and bowing). This target requires a multi-disciplinary reserach activity, combining materials science, biomaterials, micro-mechanics, petrophysics and CH conservation. Such an approach will be possible by merging competences and laboratory facilities of the 3 involved Organizations: Princeton University (outgoing phase, supervisor Prof. G.W. Scherer and co-supervisor Prof. W.O. Soboyejo, world-renowned experts in materials science and micro-mechanics, respectively), the University of Gttingen (secondment, supervisor Prof. S. Siegesmund, international expert in marble deterioration) and the University of Bologna (return phase, supervisor Dr. E. Franzoni and co-supervisor Prof. N. Roveri, international experts in materials for CH conservation and HAP for bio-medical applications, respectively). Under the guidance of these experts, the Experienced Researcher (ER) will receive high-level training-through-research and will considerably deepen and diversify his knowledge, by also attending academic and training courses, thus developing a multi-disciplinary expertise. This new expertise and the publication of research results in high-level journals will enable the ER to achieve a fundamental advancement towards the fulfilment of his career development objective, which is to become a tenured researcher in EU academia.;244269;244269;H2020-MSCA-IF-2014;MSCA-IF-GF;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;IT;;; 195197;655965;DataLocAbstractions;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Advanced Programming Environments for Exascale Data-Centric Computing;1/04/2015;31/03/2017;;"Power efficiency has emerged as the primary design constraint for the next generation of computing systems and the dominant source of energy consumption has shifted from computing elements to the movement of data. This shift will make locality of data the new programming challenge of the decade. However, current programming environments take a compute-centric approach and do not reflect the realities of the architectural trends. For performance and energy efficiency reasons, there is a critical need for a new data-centric programming paradigm that takes data locality as a primary criterion. Moreover the next generation of high performance systems (Exascale Systems) will be equipped with 2048-core chips, requiring applications to expose over a thousand-way concurrency. For a smooth transition to these advanced technologies, this project proposes a theoretical foundation and programming abstractions; embodied in an API (Application Programming Interface) that provides a rich interface to address the dual challenges of data locality and increased on-chip parallelism for emerging parallel computing systems. The ultimate goal of the project is to integrate the proposed API into real-life applications that are of great interest to Europe. The project will study Turbulent Combustion as a motivating application class because of its importance in energy production. The proposed research, by reinventing the programming environment to better reflect the realities of future platforms, will facilitate the transition to Exascale of applications that are critical for strengthening European leadership in HPC.";145845,6;145845,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KOC UNIVERSITY;TR;;; 195141;655609;ADRIA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Adriatic Perspectives: Memory and Identity on a Transnational European Periphery;1/02/2016;31/01/2018;;"This project analyses the construction of collective identity and territorial belonging by examining selected monuments in the historical region of the northern Adriatic that today is shared by Italy, Slovenia and Croatia. The links between historical memory and modern forms of identification are most complex and unstable in ethnically mixed regions with a long record of political and symbolic border shifts. Building on my previous archival research on the history of the region, I aim to develop a more complex understanding of the links among identification, belonging, nationality and the symbols used to invoke all of them. This project will apply the tools of various disciplines, including history and anthropology in order to understand how cultures of remembrance and politics of memory form, intertwine and overlap in transnational areas. In this new project, I am adopting a genuinely comparative and transnational perspective and I must test new methodological arguments by applying the methods of emerging border studies. The intertwining of these two methodologies is still underdeveloped in historical research.
I will analyse the memory landscapes of three port-cities from the beginning of the twentieth century to the present: Trieste/Trst (Italy), Koper/Capodistria (Slovenia), and Rijeka/Fiume (Croatia). The project is divided in five work-packages: Management (WP 1), Dissemination (WP 2), Imperial Sites of Memory (WP 3), World War I Sites of Memory (WP 4) and World War II Sites of Memory (WP 5). With this project I will make an original contribution to the modern cultural and social history of Europe that should be of interest to scholars, decision makers, cultural managers, teachers and to European society in general. My stay at the EUI will not only increase my historical expertise, teaching experience, networking opportunities, research and language skills, but will also have long-term effects on my integration in the international scientific community.";172477,2;172477,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN UNIVERSITY INSTITUTE;IT;;; 195010;654889;ITNUN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Family, Power, Memory: Female Monasticism in Italy from 700 to 1100;1/10/2015;30/09/2017;;Recent history amply demonstrates the importance of religious belief as a fundamental historical force. In studying early medieval Europe, we see how crucial it has been in the creation of our own identity, underlying our belief systems, cultural assumptions and core values, as well as our institutions. Modern history and anthropology help us pose questions of immediate concern on ethnicity and nationality, women and gender, identity and belief. I have engaged with these issues previously, with a multidisciplinary mix of history, anthropology, art history and archaeology. This research project on Italian female monasteries from 700 to 1100 is also comparative and interdisciplinary. To understand medieval society, it is essential to understand monasticism, and crucial to include Italy. I propose to bring together an integrated and broad-sweeping perspective by joining these together, and to approach the study of religious women as a laboratory for exploring the complex relationship between gender and power. Royal or aristocratic monasteries have sources detailing the names, background and activities of nuns, representative of the political and ethnic composition of Italian society. To study the evolution of nunneries makes it possible to trace changes in Italian political, social and cultural patterns, with the intermingling of family and politics. Understanding the tensions between early medieval Italian societys male-controlled political and religious power, and the influence of noble women as queens and nuns, is essential for grasping womens ideological and spiritual power, and for recognizing the changing configurations of medieval Italy, a key factor for comprehending some issues still at stake in Italian society today. Generally, a study of key mechanisms concerning the relationship between women, religious belief and behaviour, and politics and society can, through comprehending these in the past, illuminate key aspects of modern European societies.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA CA' FOSCARI VENEZIA;IT;;; 195061;655162;STROMINGER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Strominger system of differential equations;1/07/2015;30/06/2017;;"This project is devoted to the study of a system of partial differential equations of great relevance in modern geometry and theoretical physics. The Strominger system arises in the theory of heterotic supergravity and has been proposed by Shing-Tung Yau as one of the fundamental perspectives of complex geometry, in relation to the moduli problem for Calabi-Yau manifolds. The goal is to complete four research tasks, designed, on the one hand, to make progress on Yau's conjecture for the Strominger system and, on the other hand, to understand rigorously, in one simple example, a conjectural, fundamental, symmetry of the underlying physical theory, known as (0,2)-mirror symmetry. This will be achieved using the cutting-edge theory of generalized geometry introduced by N. Hitchin.

The expertise of the supervisor L. lvarez Cnsul and the host group at the Instituto de Ciencias Matemticas (ICMAT, CSIC), leaders in the research line moduli spaces and geometric structures, combined with the expertise of the experienced researcher M. Garcia Fernandez, constitutes an essential backup and impulse for the achievement of the objectives of this project. The host group and ICMAT, in close relation with the Institute of Theoretical Physics (IFT) in Madrid and the Mathematical Institute in Oxford (Hitchin Laboratory), ensures an outstanding training of the applicant through the overall implementation of this research action. In addition, the ICMAT provides an exceptional atmosphere and management structure, and all the necessary infrastructures for the success of the Marie Curie action.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195133;655541;HISTHEOL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;History and Theology;1/09/2015;31/08/2017;;'History and Theology: the creation of disinterested scholarship from dogmatic stalemate (ca. 1525-1675)' will deal with the question of how and why the seeds of religious tolerance came to be sown in an age of confessional polemic. This project will explore the idea that an unexpected consequence of religious polemic was the growth of disinterested scholarship, which, in turn, led to increased tolerance of religious differences. Indeed, once the strict rules and staunchly held positions of the rival confessional antagonists became known and established, scholars were able to pursue their research relatively freely within this framework and even across confessional boundaries. It became possible to describe change and diversity as historical facts rather than as simply polemical weapons in a battle of the books. In turn, this paved the way for the religious tolerance championed by several influential Church histories of the Enlightenment. The project will focus on two cultural zones: England and the Italian peninsula, in order to conduct a comparative study of a carefully selected number of key scholars from rival confessions and scholarly traditions. By means of a carefully calibrated dissemination strategy, this project is intended to have a wider impact on Europes troubled multi-faith society of the early twenty-first century by providing a fresh, new historical narrative which adds intellectual foundations to the moral desirability for mutual recognition and appreciation of diversity in religious debate.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of York;UK;;; 195079;655262;CITISEX;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding the role of sensory ecology and species interactions during sexual signal adaptation to an urbanizing world;1/05/2015;30/04/2017;;"Humans are rapidly transforming natural ecosystems into urban areas, leading to an alarming loss of biodiversity, in particular in the tropics. Some of this biodiversity loss could be mitigated if species are able to adapt to these evolutionary novel urban environments. An important aspect of urban success concerns adaptation to a sensory environment that is heavily affected by acoustic noise and artificial light pollution. Animals can for instance alter their sexual signals to optimally attract mates in the novel urban habitats. However, such change in sexual traits may at the same time attract more unwanted eavesdroppers, such as predators and parasites.
The aim of this proposal is to understand whether and how sexual communication signals can adapt to the urban environment. The first research objective addresses how signal traits can change in response to the altered sensory environment of cities. The second research objective addresses how signal change affects both attraction of mates and unwanted eavesdroppers present in urban areas.
For the first objective, the researcher, Wouter Halfwerk, will be trained by the host to adopt a trait-based approach. He will record sexual signals of male tngara frogs and assess whether signal components differ between urban and forest habitat and whether these differences are related to differences in sensory environment. For the second objective, he will receive training in the field of the evolution of species interactions. He will play urban and forest recorded signals in urban and forest environments to test their attractiveness to females as well as predatory bats and parasitic flies.
The training and research experience will enhance the researcher's knowledge in both fields and will put him at the forefront of studies on urban ecology and signal adaptation. The action will thus greatly enhance his chances of returning to the EU with the ultimate goal to start his own research group.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;STICHTING VU;NL;;; 195204;656035;DRYFUN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Linking plant functional diversity to ecosystem multifunctionality in arid systems worldwilde;1/10/2015;30/09/2017;;"The relationship between plant functional diversity and ecosystem functioning has been hotly debated, and previous research has shown direct feedbacks effects of functional community structure on ecosystem processes. However, previous studies have not considered indirect effects via changes in biotic interactions, and this is an emerging and crucial challenge for community and ecosystem ecologists. The DRYFUN project aims to assess the ultimate effects of biotic interactions on ecosystem processes of global drylands, by coupling a multi-trait approach with an observational database from 236 sites distributed among all continents except Antarctica. Its main objectives are to: (i) test the importance of abiotic and biotic processes for community structure in global drylands, (ii) assess the importance of within- and between-species trait variability for functional diversity, (iii) assess both the direct and indirect impact of dryland functional diversity on ecosystem multifunctionality (i.e., the provision of several ecosystem processes simultaneously; multifunctionality hereafter) at multiple spatial scales and (iv) explore the importance of taxonomic, functional and phylogenetic diversities on multifunctionality. The DRYFUN project is a unique opportunity to test the universal impact of functional diversity on dryland ecosystem functioning, and to provide data for establishing relevant management and restoration strategies for drylands.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD REY JUAN CARLOS;ES;;; 195187;655889;MYCRONICHE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;QUANTIFYING THE EXTENT FUNGAL MYCORRHIZAL COMMUNITIES AFFECT ORCHID NICHE BREADTH AND GEOGRAPHICAL DISTRIBUTION;1/09/2015;31/08/2017;;"Understanding the factors that underlie species distributions is a fundamental goal of ecology. With climate change there is increased importance to quantify how species distributions will change in a European context. Orchids are particularly sensitive to environmental conditions. Mycorrhizas are vitally important in determining the population occurrence of orchids, as orchid seeds rely entirely on fungi to provide nutrients in order to germinate and establish. While there have been major advances in the use of molecular tools in identifying mycorrhizal communities, no study has yet investigated how mycorrhizal communities influence the likelihood of population establishment over large geographical ranges. MYCRONICHE will bring together innovative approaches in pyrosequencing, ecological experiments, and species distribution modelling to quantify how environmental factors can lead to population adaptation. We plan to investigate three members of the orchid genus Spiranthes that are in decline in Europe. We will (i) model the distribution of Spiranthes species, (ii) perform reciprocal translocation experiments will be used in conjunction with control greenhouse experiments, and (iii) determine mycorrhizal limitation by experimentally adding seeds to habitats where the orchid species should occur. By training in novel molecular tools, the skill-set of the candidate will be advanced by participation in MYCRONICHE. There will be a dedicated training and transfer of knowledge program that will involve the researcher; (i) taking advanced courses in bioinformatics and (ii) teaching courses in spatial statistics at the host institution. By combining cutting-edge molecular tools, elegant experimental approaches, and innovative methods in spatial statistics and species distribution modelling, MYCRONICHE would go a long way to improve our understanding of how mutualistic interactions co-evolve in space and help understand how populations will respond to climate change.";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 195043;655059;PHOEBUS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;PHOto-induced Energy flow in Bio-inspired molecular circuits probed with Ultrafast two-dimensional Spectroscopy;1/10/2015;30/09/2018;;"Solar energy is forecast to cover an important fraction of the worlds energy necessities over the next century. The energy captured from sunlight will be used to drive photovoltaic cells or to produce solar fuels, thus Scientists must learn how to harvest, transfer and store it efficiently. In this framework, the PHOEBUS project aims at providing the design of innovative chemical structures (molecular circuits) that can control in sophisticated ways the flow of excitation energy.
The project focuses on bio-inspired molecular circuits, where several light-absorbing molecules are linked together to form antenna systems displaying ultrafast electronic energy transfer (EET). We aim to identify and understand how coherent effects can direct, control, and optimize energy flow after photo-excitation. PHOEBUS will answer to the following questions: (i) does coherence radically change excitation transport compared to incoherent hopping of excitation? (ii) how can we design chemical structures that use coherence in light harvesting? Two-dimensional electronic spectroscopy (2DES) is the ideal experimental tool to track EET and unveil coherent couplings in multi-chromophoric complexes. This optical technique is at the frontier of ultrafast spectroscopy. We will develop a 2DES apparatus using sub-10fs optical pulses and we will use it to determine the quantum-chemical rules guiding ultrafast EET in these innovative systems. The combination of femtosecond nonlinear spectroscopy, quantum chemical calculations, and chemical synthesis will contribute to the ultimate ambitious goal of changing the way artificial light-harvesting technologies are designed.";244269;244269;H2020-MSCA-IF-2014;MSCA-IF-GF;POLITECNICO DI MILANO;IT;;; 195210;656089;FatherMotherland;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fatherland as Motherland. Unstable Gender and Nation in Italian Great War Literature;1/09/2015;31/08/2017;;"'Fatherland as Motherland. Unstable Gender and Nation in Italian Great War Literature' is an interdisciplinary project exploring the interplay between nationalism and gender in Italian Great War literature. By tackling a diverse range of texts (pamphlets, prose fiction, memoirs, diaries, propagandistic publications), it will analyse gender patterns at work in Italian Great War literature and disclose their unstable relationship with nationalist ideology. WWI literature provides an extraordinary testing ground for exploring nationalist discourse in its ambivalences in that it absorbs its tenet, while reshaping it and releasing its instabilities. Such an approach proves highly needed: Italian WWI literature has been usually employed to describe the passage to the fascist period as if it were a homogeneous ideological set that could explain the rise of fascism. FatherMotherland will argue against both these premises (ideological stability of Italian WWI literature; its consistency with fascist culture) by means of an inquiry focusing on gender issues. The project will develop along three main lines: 1. The representation of manliness and virility; 2. The rhetorical features of the icon of the motherland; 3. The re-fashioning of the war literature canon in the fascist period. FatherMotherland has the ambition to foster a better understanding of the cultural roots of nationalism, which today threatens the process of European integration.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195046;655092;DebtRisks;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Public Debt: Risk Management and Restructuring Optimization;1/06/2016;31/05/2019;;"'Much we have been learning about the flawed design of eurozone form the current crisis. Non-optimality of euro as a currency zone, banking system fragmentation, weak institutional structures, insufficient political integration, lagging competitiveness and global imbalances, are all blamed for the crisis. At a country level problems are attributed, according to The World Bank and IMF, imprudent public debt management, weak macroeconomic management, and debt overhang.

Our project looks into these over-arching challenges with the broad objective to: 'Develop the capacity for risk management of public debt that can be used in response to crises, and to analyze policy proposals for debt restructuring and common assumption of debt in a currency union'. The eurozone crisis challenges us to develop our capabilities for public debt management and advance the state-of-the-art.This is the purpose of the project.
The four specific research tasks, taken together, advance the broad objective:
1. Develop an asset-and-liability management framework for risk management of public debt.
2. Operationalize the framework using multi-period stochastic programming integrated with multi-factor simulations.
3. Extend the optimization model to incorporate debt sustainability analysis and study debt restructuring of crisis countries.
4. Extend the simulation models to integrate current proposals for EU-bonds in public debt risk management.
The project is devoted to complementing existing skills and broadening the fellow's knowledge base to develop models for asset-liability management optimization and EU-bond pricing, implement and calibrate them using market data, and demonstrate their efficacy in addressing policy issues for public debt management in crisis countries. The models will be tested in depth on the interesting case of Cyprus, for which we have special knowledge and data, on IMF stylized examples, and for the Italian and Argentinean debt where we also have access.'";253954,8;253954,8;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY OF CYPRUS;CY;;; 195126;655534;SmartCloudsODC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;SmartClouds Orbital Dynamics and Control;1/09/2016;31/08/2018;;"This Action, entitled SmartClouds Orbital Dynamics and Control (SmartCloudsODC), will deliver radical new methodologies for orbital dynamics and control of multi-spacecraft systems to investigate new easy-accessible space-based products and services for Europe. Thanks to the advanced in Miniaturised Electromechanical Systems technology, a new class of low-cost, low-risk space missions - based on multiple cooperative elements - is arising. Assuming smart-clouds of vast numbers of femto-spacecraft, this Action will move from the classic - deterministic - celestial mechanics approach to a new paradigm in space mission design - based on stochastic analyses.
Through the excellent inter/multi-disciplinary quality of the training by worlds leading academic experts in Astrodynamics at the Institut dEstudis Espacials de Catalunya, this Action offers novel research methodologies and solutions to orbital dynamics problems including real-world uncertainties. Moreover, a crucial inter-sectoral Secondment at Dinamica Srl, a highly specialized Italian SME in space mission design at large, generates an ensemble of knowledge and resources, enabling the Experienced Researcher to fully develop his potential. This Action will enhance the ER capabilities to devise radical new space concepts in order to broad space-access to a wider European users community, also beyond the Aerospace sector, at extremely low-cost. The opportunities offered by this Action will boost the ERs career allowing him to emerge as an independent researcher and as a leading actor in the game-changing the space sector.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT D'ESTUDIS ESPACIALS DE CATALUNYA FUNDACION;ES;;; 195338;656841;metaC-Hfunct;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;CO2 as a traceless directing group for catalytic meta C-H olefinations;1/04/2015;31/03/2017;;"The development of methods for the transition metal-catalysed functionalization of C-H bonds is revolutionizing synthetic organic chemistry by providing tools to simplify and accelerate the synthesis and modification of a myriad of known and still unknown organic molecules including aromatic compounds. However, in these processes, the ability to discriminate between C-H bonds for subsequent transformation into other functional groups still remains as a major challenge. To date, much progress has been made on developing strategies for the ortho-functionalization of arenes, mainly through the derivatization of the substrates with directing groups. meta-Functionalization approaches, on the other hand, are extremely scarce despite eta-substitution is a widespread motive amongst biologically active molecules.
The research outlined in this proposal aims at developing a process that makes use of CO2 as an invisible directing group leading to an array of novel direct meta-functionalization methodologies. To do so, we envision a one-pot strategy involving a carboxylation ortho to an R group followed by a tandem CO2H directed ortho-functionalization/decarboxylation process that affords the desired meta-functionalized products and releases again the CO2 employed as the directing group.
The realisation of the objectives of this project will push forward the state-of-the art in the area of C-H bond activation by providing step economical access to molecules that are difficult to prepare via conventional multistep routes.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 195182;655857;FITINV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fitness consequences of chromosome inversion polymorphism in mimetic butterflies;1/06/2015;31/05/2017;;Elucidating the fitness consequences of genomic innovations and variation is fundamental in understanding the process of adaptation and biological diversity. Chromosome inversions are important evolutionary events often associated with adaptation and cladogenesis. Inversion polymorphism is hypothesized to capture gene combinations favoured under certain environmental conditions, and by suppressing recombination, are thought to facilitate the segregation of co-adapted allelic variations. Nonetheless, little is known about the fitness components associated with inversions, nor their combined effect, be they synergistic or antagonistic, which determine their fate. The proposed fellowship aims to investigate whether inversions capture distinct traits whose combination produce distinct, locally adapted phenotypes, and to determine to which extent recombination suppression carries a fitness cost. The Neotropical butterfly, Heliconius numata, is an excellent model to tackle those questions. This toxic butterfly always displays a high polymorphism of predator-warning colour patterns within populations, with up to seven distinct morphs coexisting within a given locality. This perplexing polymorphism is under the control of a single supergene locus, and alleles associated with distinct morphs are characterized by different combinations of chromosomal inversions. The originality and the evolutionary relevance of the polymorphic mimicry inversions, as well as the availability of both genetic and ecological knowledge in this system, will enable us to significantly improve our understanding of the fitness consequences of inversion polymorphism, and will elucidate how biodiversity can be affected by the interaction of both ecological and genomic factors.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195378;657025;MOCT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Spectral Theory of Non-Selfadjoint Markov Processes with Applications in Self-Similarity, Branching Processes and Financial Mathematics;1/07/2015;30/06/2017;;The project contextually sets up a novel framework to study the spectral-theoretical properties of classes of non-selfadjoint (NSA) operators related to Markov processes (MP) via their intertwining to a continuous path selfadjoint (SA) MP. Conceptually, this means that the jumps of each class of NSA MP can be considered a perturbation of one SA MP realized by an intertwining kernel. This approach can have far-reaching consequences for understanding classes of MP as the reduction to SA MP leads to well-studied objects whereas the spectral theory of NSA operators is far from understood. The price of that is the non-invertability of the intertwining kernels. This framework is explored and crystallized by a challenging, detailed spectral-theoretical study of an enormous class of NSA operators directly arising from the key phenomenon of self-similarity and in duality from branching. This is achieved by a synergy of research fields complementing each other to obtain the spectral properties of those operators culminating in the derivation of spectral expansions of the generated semigroups. As a result of this synergy, a number of tools and techniques with impact, including applications to fields beyond the scope of the project, are derived. A particular development in the area of recurrent equations and special functions will be unexpectedly exploited to the effect of a comprehensive theoretical and applied study, including numerical schemes, of key quantities in financial and insurance mathematics such as Asian options and perpetuities. A training-through-research in line with the fellows affiliation to the host institution and the proposed secondment will critically contribute to the optimal completion of the proposal in terms of time, scope and quality.;128994;128994;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTE OF MATHEMATICS AND INFORMATICS AT THE BULGARIAN ACADEMY OF SCIENCE;BG;;; 195161;655726;SAT STABILIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nonlinear Sampled-data Attitude Stabilization of Underactuated Spacecraft;1/10/2015;30/09/2017;;"Space stakeholders manifest an increasing interest in small satellites dictated by reduced, global costs and time to market. Since redundancy is kept to a minimum, achieving attitude stabilization in actuator failure mode with the remaining control torques can offer a fail-safe operation mode, improving the reliability of the attitude control system. The, still open, underlying control problem is challenging, since the nonlinear underactuated system is nonholonomic, admitting only non-smooth stabilizing feedback. Depending on actuator type and additional restrictions on the symmetricity of the spacecraft or its angular momenta, non standard, discontinuous or time-varying solutions have been proposed. Though any continuous-time controller is inevitably implemented digitally on the on-board computer, leading to loss of performance or even destabilization, the effect of sampling is never considered in the state-of-the-art.
The aim of the present proposal is to develop novel control algorithms for three-axis attitude stabilization of an underactuated spacecraft in actuator failure mode without significant performance degradation with the remaining control torques. To this purpose, we follow a sampled-data methodology that considers the sampling issues from the beginning in the design process. Theoretical investigations will be conducted for ad-hoc digital solutions based on equivalent discrete models, finite computability and multirate control laws, permitting to impose digital performance objectives that cannot be set in continuous-time. The quality of the innovative algorithms developed is assured by extensive software simulations and application on an experimental attitude control platform. In-orbit technology demonstration and testing, and exploitation of the research outcomes are the focus of the industrial secondment foreseen. The applicability of the results to general classes of underactuated mechanical systems and other related control problems is expected.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA;IT;;; 195119;655492;Digiseal;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Byzantine seals in a digital age: new tools for European research;1/09/2015;31/08/2017;;"The study of the Christian medieval eastern empire (Byzantium) can not rely on resources in manuscript form: as in most ancient and medieval societies, documents were authenticated by sealings, and unlike those documents, today lost, seals survived in large quantities, largely in museums, libraries and private collections. The seals contain descriptions of the persons responsible and their chosen iconography; they have the potential to fill something of the documentary void, if they can be made readily available in searchable form, and associated with other relevant sources. Over the years, scholarly understanding and analysis of Byzantine seals (sigillography) has been improving, but the resultant publications are expensive and not easily accessible; recently an international network of scholars has been discussing the possibility of online publication of this material, using the subset of TEI-XML markup known as EpiDoc, developed initially for inscriptions, coins and papyri, with particular input from King's College London, where this fellowship will be based. This proposal is to allow me to become the first expert in SigiDoc publishing seals in EpiDoc as a resource for scholars, teachers, and the curators who need to make their materials comprehensible to a wider public. The training will refine my skills in Byzantine sigillography, and introduce me to the Digital Humanities, the advanced application of information and communication technologies in humanities research and teaching: I will learn to use a range of tools in a totally independent way, being a crucial asset for the development of my career. The outcomes will be: 1) a digital corpus of Byzantine seals, in a full scholarly edition, intended to serve as a pilot and to establish standards; 2) a set of tools and protocols for others to use; 3) guidelines collecting and explaining those tools: the aim is to enable and encourage interoperability between projects in Europe and beyond.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 194995;654795;FAANon;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A functional analytic approach for the analysis of nonlinear transmission problems;1/12/2015;30/11/2017;;"The purpose of the research plan is the development of the method called Functional Analytical Approach (FAA) for the analysis of singular perturbations of nonlinear transmission problems. The techniques proposed are based on potential theory and functional analysis and aim at describing the effect of perturbations in terms of real analytic functions. Both perturbations of the shapes of the domains of definition and of the coefficients of the operators will be considered. A special attention will be paid to the case of perforated and periodically perforated domains with shrinking holes and inclusions. The problems addressed are of interest also in view of inter-sectorial applications to the analysis of physical models in fluid dynamic, in elasticity, and in thermodynamic. Concrete applications will be shown in the study effective properties of composite materials, in inverse problems in acoustic and electromagnetic scattering, and in inclusion detection problems. The results obtained represent a novelty with respect to the existing literature for the following reasons:

the techniques of FAA are innovative with respect to the classical approaches existing in literature and allow the implementation of analytic functions in the description of the effect of perturbations;

we treat non-linear boundary value problems and transmission problems, which are relevant in application and present challenging difficulties;

we will obtain new results of pure mathematics in the frame of potential theory. In particular we will study the analyticity of certain nonlinear integral operators related to the layer and volume potentials;

we will show how to obtain explicit calculations and we will show concrete applications in continuum mechanics.

The final goal within the action is the realisation of a complete theory based on the FAA which will represent in future a key tool for the analysis of perturbed boundary value problems.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ABERYSTWYTH UNIVERSITY;UK;;; 195189;655896;KOSNORTH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;THE EUROPEAN UNION AND ITS NORMATIVE POWER IN A POST-CONFLICT SOCIETY: A CASE STUDY OF NORTHERN KOSOVO;1/09/2015;31/08/2017;;"This project aims to study the role of normative power of the EU in the post-conflict society of northern Kosovo and to explore how has the signing of the Brussels agreement changed the dynamics of relations at both intra-societal (within the community of Serbs of northern Kosovo) and inter-ethnic level (Serbs of northern Kosovo vs. Kosovo Albanians and the institutions of the Kosovo government).
The project would: 1. explore the motivation and driving factors of Kosovo Serbs for their positive/negative stance regarding the signature of the Brussels agreement and the cooperation with the institutions of the Government of Kosovo and Kosovo Albanians in general; 2. assess the intra-societal split within the Serb community in northern Kosovo between those who cooperate with the institutions of the Government of Kosovo and Kosovo Albanians in general, and those who still reject any kind of cooperation, and how is the intra-societal conflict (pressure) manifested; 3. evaluate the impact of normative power of the EU in northern Kosovo; 4. assess the changes in the patterns of relations between Serbs from northern Kosovo and Kosovo Albanians on political, institutional and societal level after the signing of the Brussels agreement; 5. draw policy implications for the EU Common Foreign and Security Policy.
This research project draws from three theoretical backgrounds: the theory of normative power, theories of peacebuilding, conflict prevention and conflict resolution, and the theory of intra-societal conflict. The following research methods would be applied: interviews, surveying, focus groups (field-work in Kosovo), and study of primary and secondary sources.
From theoretical viewpoint, this project is innovative, as it questions the impact of EUs normative power in a post-conflict society. This project is relevant because certain policy implications (recommendations) for the EU Common Foreign and Security Policy could be drawn from it.";178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET GRAZ;AT;;; 195110;655444;ATMCinsituNMR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Next level real-time characterisation of Li- and Na-ion batteries by Automatic Tuning Matching Cycler (plus Goniometer) ATMC(+G) in situ NMR;1/03/2015;28/02/2017;;"Concerns about finite energy resources and the need to decrease greenhouse gas emissions have increased the use of intermittent renewable energies on the electric grid. This is not without its challenges requiring more efficient ways to store electrical energy to balance demand with supply. Li-ion batteries (LIBs) are the most desirable form of energy storage (high energy / power densities) but an increasing demand of Li commodity chemicals combined with geographically-constrained reserves will drive up prices in the future. Due to the high abundance, low costs and very suitable redox potential, Na-ion batteries (NIBs) should open new avenues of research and engineering as complementary alternatives to LIBs. This shift has to be accompanied with a deeper understanding of the chemical reactions involving the multiple cell components.
The proposed project focuses on a next step of in situ NMR spectroscopy, offering the unique possibility of non-invasive real-time studies of batteries under operating conditions to track the formation of intermediate phases and investigate electrolyte decomposition during cycling of LIBs and NIBs. Significantly different shifts of the multi-component samples, resonance broadening as well as interferences of the NMR and external battery cycler (EBC) circuit impair the experiments. Hence, we will set up a novel NMR probe system allowing on-the-fly adjustment of the NMR circuit during the measurement and sample orientation changes via an automated goniometer. Moreover, an entirely new NMR-EBC-connection design will benefit the real-time experiments. This next level Automatic Tuning Matching Cycler (plus Goniometer) ATMC(\G) in situ NMR approach will be established in a comparative study on lithium vs. sodium iron phosphate cathodes in LIBs and NIBs, respectively, including the application of new electrolytes to improve battery safety and cost factors. The application to a wider range of systems will include Na-Sn anodes for NIBs.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195064;655176;BlaC E-assay;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Portable electrochemical assay system for on-chip quantitative estimation of bladder cancer biomarkers in real samples;5/10/2015;4/10/2017;;Cancer is a leading cause of death worldwide and the best approaches to improve cancer survival rate is to diagnose it at an early stage. In spite of the rapid explosion of new technology platforms, traditional optical ELISA is used in clinical practice, which is laborious, time-consuming, require large sample volume and suffer from low sensitivity. On the other hand, recently proposed electrochemical sensors which promise easy operation, accuracy, high sensitivity, low cost and compact size mainly suffer from background signals, non-specificity and selectivity in clinical samples. Therefore, there is an urgent need to solve the key issues in the development of clinically relevant and commercially viable technologies that enable screening of high-risk individuals for cancer at an early stage. The proposed program is to develop a reliable point-of-care (POC) diagnostic system based on a multidisciplinary approach of integrated microfluidic and electrochemistry for multiple biomarker detection in clinical samples. The proposal aims at finding solutions for key issues of non-specificity, sensitivity and selectivity in clinical samples for sensitive and multiplexed detection. The proposal will address the above mentioned challenges, via separation of assay chamber and detection chamber with innovative surface chemistry and microfluidic design with electrochemical detection techniques. Work will be focused on bladder cancer as a test model to solve the above mentioned issues. The proposed device will be of bench top size and have capabilities to detect a panel of 3 or more biomarkers simultaneously. The successful outcome of the project will result in high impact publications, technology know-how and IP, which will be used to design and develop a prototype device. A secondment at Applied Enzyme Technology Ltd, Gwent Group (GWENT) will be used to study optimization of sensor shelf life and to ensure the developed system meets industrial standards.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BATH;UK;;; 195177;655841;InterAcTEV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genome-wide analysis of RNA and protein interacting profiles during a plant virus infection;1/05/2015;30/04/2017;;Plant (\)strand RNA viruses account for important losses in crop yields worldwide. They complete complex infectious cycles by replicating, moving and inactivating plant defense mechanisms through multiple interactions of their RNA or proteins with host factors. Plants have evolved two main antiviral immunity systems operated by ARGONAUTE (AGO) proteins that target viral RNAs in the RNA silencing pathway or by resistance proteins that recognize viral-encoded proteins through protein-protein interactions. However, neither the identification of AGO target sites in viral RNAs nor the elucidation of the entire repertoire of proteins interacting with viral proteins has been reported for any plant virus. Now, the recent development of new technologies (and associated tools) such as high-throughput DNA sequencing and high performance mass spectrometry (MS) platforms makes possible to address these questions at a genome-wide level. InterAcTEV will combine these new technologies to study the recently described Arabidopsis/Tobacco etch virus (TEV)-TAMPS pathosystem with a multidisciplinary approach aimed to identify AGO target sites in TEV RNAs and to generate the first complete protein-protein interactome map for a plant virus. First, RNA-immunoprecipitation coupled with high-throughput sequencing methods will be optimized to identify AGO target sites in TEV RNAs at a genome-wide level. Second, we will combine novel high-affinity purification methods with MS analyses to identify the specific pool of Arabidopsis proteins interacting with each TEV protein. InterAcTEV will generate key knowledge to open new avenues for the understanding of resistance mechanisms in plants and to develop novel antiviral strategies for crop protection and securement of worlds food supply. Finally, the funding of InterAcTEV will allow the Experienced Researcher to initiate his own research project in the host laboratory and facilitate his transition to an independent research position in Europe.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195028;654985;Brain Metastases;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Role of Circulating Monocytes in the Development of Brain Metastases;1/05/2015;30/04/2017;;"Brain metastases, particularly from breast cancer, are a significant clinical problem. About one fifth of breast cancer patients that develop metastatic disease will experience brain metastases. Survival is extremely poor, with a median survival of approximately three months. One of the main issues with treating brain metastases is the late stage at which the majority of brain metastases are diagnosed and the ineffectiveness of available therapies as a consequence. At this late point, it is often too late for standard therapies to have a meaningful effect on the progression of the tumours.

In recent years, the role of the immune system in the progression of systemic metastases has been described, with circulating monocytes being found to play a significant role. However, little is known about the pathogenesis of metastases within the brain. The brain possesses a very different environment to the rest of the body, with the blood brain barrier (BBB) tightly regulating the movement of nutrients, drugs and cells into the brain. Consequently, the processes that modeluate metastasis progression in other organs, such as lung and liver, may not be reflected within the brain owing to its unique environment. The overall goal of this fellowship, therefore, will be to determine the role of circulating monocytes in the development of brain metastases from breast cancer with the aim of identifying potential therapeutic routes.

We believe that circulating monocytes may play a significant role in the development and progression of brain metastases as a separate, distinct population from the resident macrophage population (microglia) within the brain. We hypothesize that there is significant circulating monocyte infiltration into brain metastases, which is associated with increased BBB breakdown and disease progression. On this basis, we propose that inhibiting these circulating monocytes will significantly reduce both initiation and progression of brain metastasis.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195095;655341;LARP4MOT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structural and functional studies of LARP4, a new RNA binding protein involved in mRNA stabilisation and cell migration;1/09/2016;31/08/2018;;"RNA-binding proteins (RBPs) act at multiple levels to regulate gene expression, including mRNA splicing, polyadenylation, localisation, stability, decay and translational efficiency and, although central to health and disease, much of this precise concerted regulation remains to be uncovered. The recently discovered LARP4 is an RBP that affects mRNA stability and binds to polyA as well as the polyA-binding protein (PABP). Intriguingly, LARP4 has recently been identified as a regulator of cell morphology and migration in an RNAi screen, but little is known about how control of gene expression at the translational level is coordinated during cell migration and invasion. Since aberrant cell migration contributes to the development of human diseases including cancer, chronic inflammation and atherosclerosis, LARP4 represents an excellent RBP to advance our understanding of key cellular mechanisms relating to mRNA processing and turnover.
The overall aim of the project is to understand at a molecular level how LARP4 regulates mRNA translation and how this impacts on cell migration, especially in the context of cancer cell biology, using human prostate cancer cell lines as models. For this, a multidisciplinary approach combining biochemistry, biophysics, structural and cell biology will be used.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195174;655815;MultiFUNGtionality;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Fungal diversity, ecosystem services and forest management: unravelling the role and dynamics of fungal communities in multifunctional Mediterranean forests.;1/01/2016;31/12/2017;;Forest fungi are a major biodiversity component of Mediterranean forests, and contribute to providing crucial ecosystem services. Thus, changes in fungal communities driven by environmental factors and human actions on ecosystems may have, ultimately, an impact on human well-being. Understanding and predicting such changes and their subsequent impact on the provision of ecosystem services is crucial to enable scientifically sound decision-making in landuse planning. However, our knowledge on such complex ecological systems is limited due to the high diversity of forest fungi and their cryptic nature. This action aims at addressing such complexity by contributing to unravelling how fungal diversity is affected by several drivers and, in turn, how it affects the provision of multiple ecosystem services to be further integrated into multifunctional forest management. This will be possible thanks to multi-scale, high-quality data on above- and belowground diversity and its potential drivers. Such data will be analyzed using advanced hybrid modelling techniques, and the resulting models will be combined in simulation-optimization routines to enable science-based decision making in forestry sensitive to fungal diversity. This will be the leading thread of an action that aims at having high impact on the research career of Dr. Sergio de Miguel for him to attain a position of maturity as an independent and interdisciplinary researcher.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE LLEIDA;ES;;; 195049;655109;DaRe;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Data Reliability in Networks and Storage Memories;1/06/2015;31/05/2017;;"Data networks and storage media play a key role in our modern every-day life. However, these systems are highly susceptible to errors which make successful reception/retrieval of the transmitted/stored data impossible. In data networks, errors occur due to interference with other users, due to multipath propagation of the signal, or due to component noise of the receiver. Data storage media like flash memories suffer from manufacturing imperfections, wearout, and fluctuating read/write errors. In order to transmit and store data reliably, high-performance error-correcting codes and efficient decoding algorithms are hence a necessary means.
The objective of this project is to provide novel and superior approaches for reliability in data networks and storage media. By means of error-correcting codes and information-theoretic analyses, we will make data transmission and storage more reliable against errors of different types. The first part of this project deals with the construction of better and more efficient coding schemes for networks. In particular, we want to construct subspace codes with high cardinality and low decoding complexity, and improve the reliability of multi-source networks. The second part of this project analyses the physical error model of non-volatile storage memories like flash memories with the objective of developing coding strategies which correct these errors and mask defect cells of the memory.
This project will take place at the Technion, in collaboration with Prof. Tuvi Etzion and Prof. Eitan Yaakobi. My experience in coding theory combined with the expertise of my supervisors in network coding/coding for memories is an ideal combination to achieve new excellent research results. The innovative nature of the project will boost my career possibilities and its inter-sectoral orientation will provide new opportunities for Europes high-tech industry.";182509,2;182509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY;IL;;; 194980;654682;HOLES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Highly Ordered Light-manipulators by Self-assembly;1/03/2015;28/02/2017;;The application of photonics in both everyday life and advanced science would be widespread, as they have a range of advantages as compared to electronics in many applications. However, the development of high-throughput photonic technologies has proven problematic, due to the absence of easily-scalable methods to process materials of the desired optical characteristics. My project addresses that problem by adopting a highly successful approach hat has been employed in (opto)electronics, which has led to the explosion of a new prolific scientific field, new technologies, and new products: the development of solution-based processing methods. Specifically, I propose to produce a step change in the photonics field through the employment of the Dynamic Templating Process (DTP), an elegant, fully solution-processing method, which exploits the self-assembly of water microdroplets, to create micro-honeycombs, i.e. 2D photonic crystals. As solution-processable material, I propose to use an organic:inorganic hybrid, which shows refractive indexes above 2. Then, I aim to create novel 2D hierarchical and 3D photonic structures based on thy hybrid honeycombs for optical field management. In the last stage I will transform the DTP into an industrially scalable process for photonic crystal and device manufacturing. Thereby, I propose an ambitious, multidisciplinary and self-consistent project, which encompasses the synthesis of novel materials, the development of microprocessing methods, the production and characterisation of a new class of photonic elements, and the development of industrial production processes. Hence, the project is designed to generate new knowledge as well as new disruptive technology, as it may lay the foundations for next generation photonic devices.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195363;656945;EffectorTargets;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins;9/09/2015;8/09/2017;;"In nature, fungi live in close contact with many different hosts: plants, other fungi, insects and even vertebrates including humans. They do so because the host often supplies key nutrients, which enables the fungus to grow and successfully reproduce. In many cases though, a fungus can act as a parasite and infects the host. As a result, the host mounts an immune reaction to combat the fungal infection. The fungus, in turn, has evolved ways to circumvent the immune reaction. This arms race between fungus and host has given rise to a plethora of secreted proteins that the fungus uses to suppress the host immune responses and circumvent host defence reactions. These secreted proteins from fungi that function in this arms race are commonly known as effectors. A very important plant pathogenic fungus that is predicted to encode close to 500 of such effector proteins is the barley powdery mildew fungus Blumeria graminis f. sp. hordei. Unravelling the functions of these effector proteins will provide important insights into fungal pathogenicity and host immunity. To date, the roles of the vast majority of the effector proteins are unknown. One way to elucidate the functions of these numerous effector proteins is to express each separately in model eukaryotic organisms like yeast, Saccharomyces cerevisiae, or algae, Chlamydomonas reinhardtii and identify conserved cellular targets of these effector proteins. This approach has proven to be very successful in identifying targets of bacterial effector proteins. In the project described here, this yeast- and algae-based system will be applied for the first time for fungal effector proteins.
Effectors are, besides being used by fungi to infect plants and other organisms, also a potential new source to rewire cells. When interesting conserved targets of these effectors are found, it opens up ways to use them in biotechnology and for medical purposes.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195111;655457;Metabolic cost of walking;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Stepping forward in understanding the Metabolic Cost of Human Walking;1/04/2015;31/03/2017;;"The mechanisms underlying metabolic cost of walking are unclear. This is important not only because they provide fundamental insight in human movement, but they are also essential to reduce increased cost of walking in the elderly and impaired. To understand these mechanisms, it is required to know the link between energetics at the human level and the energetics at the muscle level. Whereas the energetics at the human level is experimentally accessible, that at the muscle level is not. Current estimations greatly overestimate actual metabolic cost and hence there is no basis understanding metabolic cost of walking.
In this project I will first ever directly measure oxygen consumption of dynamically contracting muscle fibres. These experiments will be conceptually linked to in vivo experiments measuring oxygen consumption during isolated movements as well as during walking. Using these data and state-of-the art optimization techniques applied to detailed neuro-musculoskeletal models I will link energetics at the muscle level to that of a walking human and provide insight in the mechanisms underlying the metabolic cost of walking.
This grant would allow the applicant to return fully to a EU research environment and would have a very significant and direct impact on my career perspective.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;STICHTING VU;NL;;; 195162;655729;WetCarb;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Wetland Emissions of Carbon (CO2 and CH4) in China under Climate Change: Analysis, Development and Implementation;15/06/2015;14/06/2018;;Wetlands, fragile ecosystems that play an important role in the global water and carbon cycles, cover a non-negligible part of the terrestrial surface and render numerous services to humankind. Their role as carbon sinks or CO2 and CH4 sources depends on the prevailing hydrological conditions and is sensitive to rising atmospheric CO2 concentrations, regional climate change, as well as to water management and land use. Modifications of carbon and water dynamics within wetlands are already detectible and can be expected to amplify during the coming decades. Yet, numerous gaps of knowledge exist concerning their CO2 and CH4 flux quantifications and future dynamics, partly due to scarce global databases, and modelling of these dynamics are still highly uncertain. Focusing on China, where extensive wetlands exist and are projected to undergo vast changes, this project aims to analyse the response of wetland carbon emissions to changing hydrological conditions and atmospheric CO2 concentrations, taking into account contrasted regional land use and water management scenarios. An integrated approach combining measurements of CO2 and CH4 fluxes in numerous wetland types of China with new parameterizations of a dynamic vegetation model coupled with a hydrological model is proposed. The project covers changes occurring through the 20th and 21st centuries. It will be undertaken by the Researcher with two world leading teams in Earth System sciences, bringing in both expertise in modelling the terrestrial carbon cycle, datasets and knowledge of ecological processes. The research will deepen and broaden the Researchers competences, build long-term skills and collaborations, promote transfer of knowledge to China and contribute to European excellence and competitiveness. Special attention will be given to disseminating results to both the general public and the non-academic sector through a secondment.;248598;248598;H2020-MSCA-IF-2014;MSCA-IF-GF;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;;; 195013;654912;Pharmcophore-DOS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2;1/06/2015;31/05/2017;;"The proposed research aims at discovering inhibitors of protein-protein interaction (PPI) between RAD51 and BRCA2 as a promising treatment of cancer, in particular to reverse the resistance of cancer cells to radiotherapy and cytotoxic chemotherapy. The pharmacophore guided DOS approach developed in this project has the potential to be a general method for rational discovery of PPI modulators. The researcher will acquire novel technologies and develop new skills in both scientific and management aspects, which are important in his professional maturity and career plans; while the host can also be benefitted from his experience in medicinal chemistry. This action will promote the mobility inside the European Research Area and spark lasting cooperation among different European countries.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195348;656881;NBUCA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neural and behavioral underpinnings of contextual modulations in Autism;1/09/2015;31/08/2017;;Social cognition impairments, including deficits in nonverbal communicative behaviors used in daily life interactions are considered to be among the core deficits associated with Autism Spectrum Disorders (ASDs). So far, these deficits have been traditionally studied by using non-realistic stimuli embedded in abstract tasks. These tasks are not good models of the world because they lack the context of everyday-life situations. Although contextual processing during action comprehension has been extensively studied in other disorders (e.g. schizophrenia), much less is known about the role that it plays in ASD. Strikingly, those few studies that have used more ecological paradigms in which contextual information was given have shown that ASD individuals are able to improve their ability in reading out others actions. Therefore, a broader explanation of ASD which considers the influence that context, as an intrinsic part of social cognition, has on this disorder is timely and clearly required. The general aim of NBUCA is to study the neural and behavioral underpinnings of contextual modulations in ASD during action comprehension and answer many challenging questions: a) Do children and young adults with ASD have a general deficit in integrating context and behavior? If this is true, b) Does this deficit relies more on the processing of social or non-social contextual cues (or both)? Given this, an ecological context-dependent social cognition paradigm will be designed and further implemented in a set of experiments combining behavioral and psychological measures with transcranial magnetic stimulation (TMS). Overall, we expect that by enhancing contextual information ASD individuals will improve their ability in comprehending others actions. Together, our findings will provide novel insights on the impact that context has on ASD. This will be of clinical relevance for developing a more ecological framework that includes contextual sensitivity evaluation and treatment.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI UDINE;IT;;; 195080;655265;PmSust;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The project of Sustainability: the role of Project Management in developing a more sustainable economy and society;1/09/2015;31/08/2017;;"This project will investigate the role of the Project Management (PM) profession in developing a sustainable economy. Sustainability has acquired a growing strategic importance over the last 10 years bringing with it a requirement for changes in traditional practices and paradigms of production for its successful implementation. These changes are typically managed as projects and delivered by dedicated project managers, that are assumed, have the knowledge and skills to take into account the social, financial, political, cultural and environmental sustainability of a project. As such project managers, through their distinctive roles, skills and competences occupy an important position in accomplishing sustainability, but little is understood about how they do this.
Using qualitative methods such as interviews, content analysis and ethnographic observation, I will focus on how sustainability is incorporated in PM discourse and practice by studying: how the profession makes sense of sustainability, and also sustainability in practice.
The topic of the project is very timely as it addresses the sixth point currently on the Horizon 2020 agenda: Inclusive Innovative and Reflective Societies. The expected contributions of this fellowship will be in: (a) explaining the institutionalization of sustainability within PM professional practices; (b) identifying under what conditions project managers adopt sustainability practices; (c) conceptualizing sustainability in PM contexts. This project will provides me with excellent training and collaboration opportunities, which will significantly advance my future career.
This fellowship will be located in the Professions, Work and Organization (PWO) Research Group at Newcastle University where I will benefit from the groups world leading expertise on professional occupations and organizations, to enable me to develop theory and knowledge in the field of PM as a profession advancing sustainability as a practice and outcome.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;;; 195096;655350;NPCChr;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A role for nuclear pore complexes in chromatin organization during early development?;1/03/2016;28/02/2018;;During differentiation, cells undergo large-scale chromatin rearrangement, notably with the establishment of heterochromatin blocks at the nuclear periphery during the epiblast stage of development. Concomitantly, hundreds of genes are relocated to and from the nuclear periphery and their position is correlated with their expression levels. Most of these genes are associated with regulation of pluripotency, suggesting that the association of fLADs to the NL is a key parameter for proper embryonic development. Recent work of the host lab using synthetic activators showed that the chromatin rearrangement is responsible for the relocation of these genes. However, the mechanisms that govern this chromatin rearrangement are largely unknown. Here I propose to test whether a modulation of nuclear pore density allows chromatin reorganization during differentiation of embryonic stem cells (ESCs) into epiblast stem cells (EpiSCs), laying the groundwork for future analysis in vivo during embryonic development. As a complementary approach, I will determine the mechanisms that prevent heterochromatin formation at nuclear pore complexes. The use of state of the art techniques such as super-resolution microscopy, genome mapping and a multidisciplinary approach combining biology and physics will allow me to understand the role of nuclear pore complexes in the regulation of genome organization.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195034;655023;BREAKING THE MOULD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Breaking the Mould: A cross-cultural analysis of the character of bronze smiths and craft diversity in late Bronze Age Europe (1300-800 BC);1/08/2015;31/07/2017;;During the late Bronze Age in Europe (c. 1300-800BC) there was a transition in metal consumption from a restricted-access prestige material to a common medium for making practical objects. The objective of this project is to characterise culturally particular developments in bronze workshop practices using case-study areas in Europe, and through this to rethink relationships linking resource control, craft organisation and identity formation. This is achieved by measuring variability in the technological choices, skillsets and knowhow underlying smithing traditions and defining the social practices of craft production. I will employ a cross-cultural approach using three case studies: the Balkans, Central Europe and Northwest Europe. Multidisciplinary diagnostics will be used to assess technological markers that reveal intentional differences in production techniques. Methods will include 1) collating and analysing metallurgical datasets 2) recording and 3D modelling of craft traces on artefacts, 3) experimental bronze casting and material analysis. I will use these to build the first pan-European metallurgical digital resource, making specialist data more accessible and better enabling international collaborative actions. By moving to UCD, I will work closely with Aidan OSullivan, director of the Centre for Experimental Archaeology and Ancient Technology. Resources there and in the School of Archaeology provide a unique constellation for training in bronze object casting, forging and mechanical testing, along with digital 3D rendering of artefacts and data management. My career goal is to be a research leader in experimental archaeology, which this project will enable by developing a novel integrated kinaesthetic and scientific method for the study and visualisation of bronze metalworking. Through training in core and complementary skills, including teaching, supervision, and public outreach, I will develop key resources to maximise the impact of my career restart.;187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;IE;;; 195159;655703;Polyphemus;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards a new framework for reception: Gongoras poetics, new readers and the material world;1/05/2015;30/04/2017;;"Luis de Gngoras (1561-1627) two major compositions, Polifemo and Soledades (1613) represent a watershed in the trajectory of Spanish poetics; prompting a polemic over their stylistic innovations that would continue for three centuries. To date there has been suppression of the polemics politico-ideological underpinnings and undisputed acceptance that Gngoras poetry was written to be read by an aristocratic, erudite elite. Consequently research on the reception of his work has been conceptually constrained and confined within the rigid parameters of documents relating to the controversy. The primary aim of this project is to challenge these fundamental assumptions of readership and reception and to propose a new methodological framework which has at its core a confluence of: (a) archival investigation; (b) analysis (qualitative and quantitative) of material evidence with digitalised data presentation; (c) a sophisticated theoretical underpinning that conceptualises literary reception within the wider tensions of socio-cultural self-constitution. The key sustaining hypothesis is that Gngoras new readers were not restricted to the intellectually-renovated receivers anticipated by the poet, but encompassed other recipients drawn from a much broader socio-cultural spectrum (archival research carried out by the researcher informs this). Outputs include a journal article, a project website with open-access database, a book-length study and the organisation of an international conference. In line with MSCA objectives the project will enable a transfer of knowledge and interdisciplinary skills of mutual benefit to researcher and host; strengthen the contact networks of both, and enhance the career opportunities of the researcher through international exposure and inter-sectoral mobility. The project will promote collaboration between researchers, archivists and librarians, thus contributing to the recuperation of a significant aspect of Spains cultural heritage.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE QUEEN'S UNIVERSITY OF BELFAST;UK;;; 195147;655656;DURETO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rearm cultivated tomato with natural and durable resistance mechanisms from wild tomato species;1/05/2015;30/04/2017;;Insects are gaining resistance to commercially available pesticides and effective insecticides (e.g. neonicotinoids) are currently being banned. Consequently, there is a real threat that the EU vegetable production will be affected. Wild tomato species have the ability to defend themselves by producing natural defence compounds that have a toxic or repellent effect on insects. These compounds are produced and stored in glandular hairs (trichomes) on the plant stem and leaf surface. Extensive breeding in protected environments led to the loss of these defence compounds in cultivated tomatoes. It was previously shown that the introduction of the terpene 7-epizingiberene biosynthetic pathway from a wild tomato in trichomes of cultivated tomato results in an enhanced resistance to insects. However, the regulatory factors that govern the production of these defence compounds seem also essential for successful incorporation of wild resistance into breeding material. Here, I aim to discover metabolic defence mechanisms present in the trichomes of wild tomato species that can be re-introduced into cultivated tomato with a focus on post-transcriptional regulation of biosynthetic pathways. I will evaluate insect resistance in a collection of wild and cultivated tomato accessions and associate phenotypic and transcriptional data via a Systems Biology approach. I will also sequence small RNAs and compare them quantitatively with messenger RNAs to identify post-transcriptional regulations. Next, I will follow a comparative genomic approach by mapping the selected transcripts to their corresponding tomato genomes to associate polymorphisms and resistance phenotypes. These results will be directly translated into molecular markers that the industry can implement in breeding programmes. This proposal will help me become an independent researcher, combining my background in plant biology with knowledge on bioinformatics, biostatistics and state-of-the-art technology.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT VAN AMSTERDAM;NL;;; 194998;654812;HoogsCG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of a multiscale modeling strategy to decipher how hybrid DNA/RNA triplexes and G-quadruplexes affect gene expression regulation;1/05/2015;30/04/2017;;This proposal concerns the study of non-canonical interactions in nucleic acids. These interactions, also known as non-Watson-Crick base pairing, involve single or multiple DNA or RNA strands and are increasingly recognized as having a variety of essential roles in replication forks, telomeres, and gene regulation. Since these processes occur on spatial and time scales beyond the reach of current computational capabilities, we propose to develop an innovative coarse-grain approach to describe them. This approach will tackle an important and yet unmet challenge - the correct description of non-canonical interactions at near-atomic resolution in large-scale nucleic acids. The model will be derived from exhaustive classical all-atom molecular dynamics simulations and will be validated against experimental observables including nuclear magnetic resonance spectroscopy and small angle x-ray scattering. It will be used to describe non-canonical interactions including Hoogsteen base pairs, which are the building blocks of triplex and quadruplex structures and will incorporate the effects of epigenetic marks on DNA. The model will enable the description of the sequence dependent mechanical properties of guanine quadruplexes and triplex folds on temporal and spatial scales beyond the reach of current methods. As such, it will allow us to investigate the formation and dynamics of long triplex hybrids of DNA and RNA, the behaviour of long-non-coding RNAs interacting with naked DNA, and the effects of non-canonical interactions in systems relevant to chromatin. Thus, this model will be useful to predict and understand the molecular bases of fundamental open questions in biology and has a potential impact in molecular medicine and the pharmacological industry. Overall, this approach will provide an invaluable theoretical tool to describe nucleic acid structures and dynamics, contributing to the description and prediction of a wide range of genetic and epigenetic processes.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195333;656820;CHELALZ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multitarget compounds with therapeutic potential against Alzheimer disease: Design and in vitro studies;1/01/2016;31/12/2017;;"This fellowship will provide a prolific researcher with an internationally competitive, multi-disciplinary research training at the Chemistry/Biology interface in an EU leading Bioinorganic chemistry team, preparing her to obtain her goal of a faculty position in the EU and her own research team in Medicinal Chemistry.
She will develop novel anti-Alzheimer conjugates that target multiple disease's hallmarks. Afterwards she will evaluate their in vitro therapeutic and diagnostic potential through a secondment with cell biologists in another EU country, the United Kingdom.
This research will pave the way towards the development of innovative and effective anti-Alzheimer drugs by using versatile drug combination approaches to fight this horrible and still incurable disease.
Alongside her research she will also acquire research management, leadership, presentation and teaching skills to prepare her for a successful future as an independent research group leader.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT DE BARCELONA;ES;;; 195065;655177;MUSAL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multi-scale modelling of waves of porous media with applications to acoustic control and biomechanics;1/09/2015;31/08/2017;;Novel techniques will be developed to model the mechanics of porous media and elucidate wave propagation characteristics in these complex two-component heterogeneous materials. This will establish a more rigorous theoretical framework and provide deeper physical insight than currently possible. The applications and natural occurrence of such media are widespread, with important applications in acoustics, bio-mechanics, geophysics and engineering. Within this proposal, two areas of application will be explored in collaboration with non-academic partners. Firstly, results will underpin methods to better control environmental noise. As can be seen from the EUs Policy on Environmental Noise this is an issue of significant concern, the policy stating that The largest impact of environmental noise is on annoyance and sleep disturbance, health effects of noise to which more than 30% of EU population may be exposed. The external costs of noise in the EU amounts to at least 0.35% of its GDP, but much higher values may be found as new findings become available. In general, it is considered amongst the most relevant environment & health problems, just behind the impact of air quality. The methods developed will have significant application to acoustic optimisation and control. Besides acoustic optimisation, determination of wave characteristics and better modelling of porous media have profound implications in modelling bone. Bone is a heterogeneous material with a complex hierarchical structure, occurring in two main forms, a dense solid and a porous medium filled by a viscous marrow. The EUs Executive Agency for Health and Consumers estimates that 22% of the EU population experience long-term muscle, bone and joint problems, from which significant economic and social issues result. The results we will obtain, and resulting methodologies established, will have far reaching implications for the detection and monitoring of a number of chronic bone and joint conditions.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF KEELE;UK;;; 195019;654924;NANOLIPID;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding key factors for the use of bioactive lipid nanoparticles to modulate the functionality of complex food systems;1/10/2015;30/09/2017;;The use of lipid nanoparticles as carriers of lipophilic functional compounds is emerging as a promising way to efficiently deliver food ingredients. There are evidences that bioactive compounds incorporated in lipid nanoparticles present an enhanced bio-accessibility in the gastrointestinal due to their small droplet size. However, the incorporation of active nanosized ingredients in foods remains a challenge for the food sector. Lipid nanoparticles may interact with the food matrix components causing destabilization phenomena or binding, which in turn might decrease their biological activity. Moreover, food processing operations used after the incorporation of the active lipid nanoparticles may have an impact in their properties. In this context, NANOLIPID, aims to contribute to the design, characterization and application of bioactive lipid nanoparticles towards a more rational and optimal use of food ingredients. For that purpose, the major goal of this proposal is to obtain stable lipid nanoparticles containing carotenoids (?-carotene, lycopene and lutein), incorporate them in complex food systems and assess their digestibility and bio-accessibility under in vitro simulated digestion conditions. NANOLIPID is a multidisciplinary proposal covering the formulation of lipid nanoparticles and use of state of the art techniques for nanomaterial characterization, food processing, and analysis of digestion and in vitro bio-accessibility. The fellow, who recently obtained her PhD degree in the University of Lleida (Spain), focuses on the study of the functional properties of lipid nanoparticles. Currently, she is post-doctoral researcher at the Food Science Department at University of Massachusetts (USA), one of the most active research groups in the field of delivery systems. The applicant would be one of the first researchers in Europe to study the real implications and benefits of incorporating functional lipid nanoparticles in food products.;160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 195081;655271;EpiNKT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transcriptional and epigenetic control of innate-like T lymphocyte development;31/08/2015;30/08/2017;;"Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims:
1) Determine target genes bound by E proteins,
2) Determine the epigenetic chromatin states and
3) Determine the role of chromatin modifiers
in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.";164653,2;164653,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING;EL;;; 195132;655560;CHENGEN;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An integrated framework to investigate the genetics of changing environments;1/07/2015;;;An important scientific challenge this century is to understand how biodiversity responds and adapts to global environmental change so we can predict and prepare for the effects of major conservation threats. Future climate change will produce a range of new selection pressures on populations due to increased temperatures, droughts and extreme events, while continuing anthropogenic habitat loss is likely to exacerbate pressures and limit future range shifts. The CHENGEN project aims to establish a novel multidisciplinary framework for understanding and predicting the responses of biodiversity to environmental change by integrating genomic tools with ecological, spatial, demographic and mathematical modelling. Societal impacts are at the heart of this project, and its main aim is to provide the evidence base for protecting and sustainably managing biodiversity. The project focuses on threatened European forest bats as indicators of biodiversity responses to environmental change. Project objectives are to initiate cross-European collaborations to evaluate the effect of environmental changes on species ranges, generate genomic resources to study evolutionary adaptations, develop novel modelling tools to assess survival prospects and landscape barriers to range shifts, and provide conservation management solutions. Objectives will be achieved through predictive distribution modelling for all European forest bats (WP1) and a population genomics study of an endemic Iberian forest bat, Myotis escalerai (WP2-3). Beyond enabling European research mobility, the project will provide training in state-of-the-art research skills by world leading experts within the host institutions multidisciplinary research environment. Knowledge transfer will strengthen genomic research in the host institution and bring a new evolutionary perspective to the study of environmental change, paving the way towards future collaborations and the applicants independent research career.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195144;655628;NanoLAPS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NANOSTRUCTURED LARGE AREA PLASMONIC SYSTEMSDEPOSITED BY GAS FLOW SPUTTERING AND PLASMA-ENHANCED CVD PROCESSES;1/04/2015;31/03/2017;;"Nanocomposites made of metallic nanoparticles (e.g. Au, Ag, Cu) embedded in a transparent matrix may display unique optical properties due to plasmonic effects resulting from the interaction of light with particles of nanometric size. This original behavior can be exploited in a wide range of applications including chemical and bio-sensors with extremely high sensitivity, spectroscopy, solar energy harvesting, and nanophotonics.

In this context, Nano-LAPS project aims at the deposition of high purity nanocomposite materials with well controlled plasmonic absorption peak in the visible or infra-red ranges. Objectives are based on the encouraging results of preliminary work realized on this subject at FhG, which establishes a solid starting point for this project. The chosen approach is based on a unique and original deposition method combining gas flow sputtering and Plasma-Enhanced CVD processes. This technology allows coating large area substrates, with the highest purity, for a wide choice of nanoparticles (Au, Ag, Cu, Al, W, and high performance conductive oxides) and matrices (SiOxCy, TiOxCy, plasma polymers).

The host organization senior researchers and management have an established reputation in research on thin films and nanotechnology, and are highly qualified to lead and to support this project, providing the best conditions for its success. Besides, the researcher has proved his capacity in leading and structuring scientific works on thin films coatings and process design. His experience will complement that of the host organization with new and original topics likely to draw scientific attention and open up perspectives for this research work.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;;; 194983;654699;OPSINEVOL;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Evolution of opsin genes in guppies (Poecilia reticulata) relative to male colour: a window into the genetics of mate choice;15/04/2015;14/04/2017;;The spectacular colours displayed by males during courtship often result from sexual selection by female choice. Female visual perception should therefore play a critical role in the evolution of male colours. In guppies, both sexual dimorphism and male colour have evolved multiple times as a trade-off between female preference and predation pressures. Populations under low-predation regimes have repeatedly and independently evolved more colourful, sexually dimorphic males, and females with relatively strong preferences for colour. I will study opsins, the visual pigments that mediate vision, to shed light into the evolutionary relationship between male colour and female preferences. Guppies present a unique opportunity to systematically study multiple aspects of opsin evolution, asking whether it mirrors the pattern of parallel evolution of sexually selected traits. Initially, I will use next-generation sequencing to evaluate the total number of opsin genes, their distribution through the genome and their conservation across populations. I will then study variation in opsin sequence and expression associated with the evolution of colourful and sexually dimorphic guppy populations. Finally, I will study divergence in the visual system, beyond opsins, using comparative transcriptomics of the retina and the brains optic lobes. The results of this work will provide a cohesive, integrative and multi-faceted understanding of the role of opsin variation in this model system of evolution by sexual selection, and will determine the role of opsins and the visual system in driving female mate preferences and male colour evolution. This project will help us understand the genetic underpinnings of key adaptive traits, linking genes to the phenotype and opening up new research agendas.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 195172;655811;NANOBIOENER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;NanoBio-inorganic generators for conversion of renewable chemical energy into electricity;7/07/2015;6/07/2017;;"Focused in the secure, clean and efficient energy challenges of Horizon 2020, NANOBIOENER (this project) proposes the development of novel bio-inorganic nanogenerators which produce electricity from renewable fuels. These systems are presented as an alternative to electrochemical-based fuel cells in order to generate electrical energy in an autonomously and efficient manner. In this context, a new hybrid system will merge biological machinery, which is able to transform a fuel into mechanic energy (pressure and vibration), with a piezoelectric nanogenerator (zinc oxide nanowires), which transforms mechanic energy into electricity. The mechanical stimuli of pressure and vibration will be generated through gas production from fuel. This reaction will be catalyzed by a biological machinery (coupled multi-enzymatic systems), integrated into the nanogenerator. These devises will produce electricity at microscopic scale, employing renewable fuel sources such as carbon dioxide and biomass, creating a zero-emissions process. This power generation system will allow several advantages over the current nanobiogenerators, namely: i) the employment of renewable fuels; ii) the independent and continuous production of electricity, in comparison with existing nanogenerators that depend on voluntary actions or random environmental stimuli; iii) the regulation of the production potential by the control of the enzymatic activity which is responsible for the mechanical stimuli. NANOBIOENERs success will produce the first report of a bio-inorganic nanogenerator powered by renewable fuels to produce clean energy thus benefiting the sustainable development of the human society. This research program will provide to Dr. Velasco-Lozano a state-of the art training at the interface between chemistry and biology.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE;ES;;; 195146;655653;KinCoop;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Do plants cooperate in reproduction? The effect of sharing pollination services on plant reproductive strategies;1/08/2015;31/07/2018;;"Although social interactions in non-sentient beings such as plants might seem unlikely, there are good reasons to expect them to be important. Because plant populations are very often strongly genetically structured, with neighbouring plants frequently being relatives, their behaviour is expected to have been shaped by natural selection within this social context. Plants interact very strongly with their neighbours, and there is an increasing body of evidence showing kin recognition and cooperation with relatives, e.g., warning against herbivore attacks and reducing resource competition. However, little is known about how plants behave in a social context in terms of their reproductive strategies. This is surprising, because reproduction is a key life-history trait defining gene transfer, and thus is closely linked to fitness and to the evolutionary potential that will eventually determine the functioning and dynamics of plant populations and communities.
Neighbouring plants commonly facilitate pollination. Therefore, the resources invested in floral attractive structures for one individual can positively impact individual fitness, but also the fitness of neighbours, increasing both individual and group benefits. Thus, natural selection should be expected to favour plastic adjustments of the resources allocated to pollinator attraction to the surrounding social environment. I will test this hypothesis, assessing how different social environments might influence optimal allocation strategies and the effect this will have on mating patterns and plant fitness. To address this objective, I will use an interdisciplinary approach that combines theoretical modelling and empirical testing, bringing tools from the sociological sciences to the study plant ecology and evolution. My project will contribute to our understanding of how plants cooperate during reproduction to alter plant population dynamics, with potentially useful outcomes for crop efficiency.";272480,4;272480,4;H2020-MSCA-IF-2014;MSCA-IF-GF;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195004;654852;Chinese Labour;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Shifting Dynamics of Chinese Labour in a Global Perspective;15/12/2015;14/12/2018;;"With the financial crisis stepping up the pressure on labour regimes around Europe, and with the European national economies increasingly subject to the vagaries of an uncertain Chinese growth, questions traditionally of interest only to Chinese labour specialists and rights advocates are taking a whole new dimension. Chinese labour issues have ceased to be local matters and have assumed a particular urgency, entering much of the political rhetoric of the European countries. Such diffused presence of Chinese labour in the European imaginary raises many questions and requires a thorough investigation. In particular, in the past few years, much has been written about a rights awakening allegedly undergoing among internal migrant workers in China. But how do Chinese workers perceive their rights? What role do Chinese state and non-state actors play in shaping this perception? And, more important, how will these shifting dynamics of Chinese labour activism affect the future of China as a world factory? Research that answers these questions is still scarce. The purpose of this study is threefold: a) analyse the expectations of Chinese migrant workers toward work hours and salaries, on the background of the minimum standards mandated by the current labour legislation; b) deconstruct the role played by different actors in shaping these expectation, with a particular attention to the role of the central and local state, the union, civil society organizations and foreign enterprises; c) address the implications of the rising expectations of the Chinese workers for EU investments in China and for the future of the country as a world factory. This research will not only give a meaningful contribution to the academic debate, but will also provide European policy-makers, companies, trade unions and labour NGOs with much needed knowledge on how to address Chinese labour issues in this new phase of the globalization process.";250518,6;250518,6;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITA CA' FOSCARI VENEZIA;IT;;; 195066;655178;HerbivoreAssociatedOrganisms;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unravelling the complexity of plant-insect interactions: the hidden role played by herbivore-associated-organisms;4/01/2016;3/01/2018;;This Marie Sk?odowska Curie Fellowship will allow a talented young researcher to pursue multidisciplinary research with an outstanding and internationally recognised group investigating plant-insect interactions. The Fellow will gain skills in a range of cutting-edge techniques for studying plant defences against herbivore attack whereas the Host group will benefit from the Fellows expertise in methods of behavioural assays not currently utilized in the group. The Fellow and the Host will address together the complexity of plant-insect interactions using a very innovative approach based on the hidden role played by Herbivore-Associated-Organisms (HAOs). In fact, insect herbivores often consist of a community themselves including bacteria, fungi, parasitic worms, parasitic wasps and viruses which may play an important role in the expression of the herbivores phenotype and consequently on interactions of the herbivore with its food plant. However, up to date, most of the studies investigating plant defences have considered insect herbivores as individual organisms, thus neglecting the role of HAOs. The Fellow and the Host propose to experimentally manipulate the HAO composition to evaluate the effects on induced plant defences from plant gene expression to wider community consequences. This project is expected to advance the state-of-the-art of plant-insect interactions putting Europe research in the forefront of the research topic. This fellowships is also ideal for reaching the researchers scientific and professional maturity, to build up long lasting collaborations and finally to establish his own group afterwards.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 195117;655487;GENOMIC FOOTPRINT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Does a moving hybrid zone leave a genomic footprint?;1/02/2016;31/01/2019;;Species are the currency of biodiversity. However, during the early stages of their evolution, species are difficult to delineate, as barriers to gene flow are not yet complete. Range expansions and contractions exaggerate the reshuffling of the genomes of hybridizing species. The key objective of this project is to experimentally test the theoretical prediction that, under hybrid zone movement, genes derived from a displaced species are left behind in the genome of an invading species, leaving a genomic footprint. I will fill an empirical void by, for the first time, testing this critical hypothesis in the wild, using genome-scale data. I have established a study system (the newt genus Triturus) that is particularly appropriate because it shows strong evidence in support of hybrid zone movement over considerable time and distance. To obtain genome-wide data, I will be trained in the cutting-edge genomic technique of target enrichment through sequence capture during the outgoing phase at the lab of Prof. Shaffer at the University of California, Los Angeles (UCLA). To transfer this important new piece of knowledge back to Europe, I will implement target enrichment through sequence capture during the return phase at the beneficiary, the University of Sheffield (USFD). At USFD the group of Prof. Butlin has unmatched expertise in hybridization/speciation research and excels in the analytical approaches required to uncover a genomic footprint. Human activities have intensified hybridization and I propose a secondment to work together with conservationists and legislators to tackle the insidious conservation problem of genetic pollution by exotic species.;269857,8;269857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE UNIVERSITY OF SHEFFIELD;UK;;; 195129;655545;FLAVODRINKS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;IMPACT OF AROMA AND AROMA INTERACTIONS ON SWEET FLAVOR PERCEPTION IN JUICES AND SOFT BEVERAGES;1/06/2015;31/05/2017;;"In efforts to help consumers improve their health by reducing their consumption of sugar, salt and fat (Europea 2006/1924/EU), the European Commission recently set new standards for the formulation, production, labeling and advertising of fruit juices (Europea 2012/12/EU). Similar regulations are expected soon for soft drinks. Soft drinks have begun to suffer a poor public image because of their high content of sugar or sugar substitutes, which the beverage industry uses to counteract or mask undesirable flavors. It may be possible to avoid the need to add sugar to fruit juices and soft drinks if we can identify aroma compounds that help the consumer perceive a drink as sweet. Understanding the interaction between aromas allow act on sweetness perceived by the consumer and get drinks with less sugar added.

The purpose of the work is to identify aroma compounds responsible for the sensory properties of fruit beverages and analyze how they may affect taste perception (sweet, acid and bitter). Fruit juices and soft drinks will be analyzed in order to characterize the main compounds involved in the perception of aroma as fruity, floral, green and sweet. Close attention will be paid to the chirality of identified compounds in order to study structure-aroma relationships (chemosensory approach). The ability of aroma compounds to interact in influencing taste will also be studied in order to identify synergistic or suppression effects. Moreover, perceptual interactions between aroma and taste will be studied using specific taste compounds.

The innovation of the proposed study lies in applying sensory-guided multidimensional chromatographic techniques to beverages, which are complex mixtures of aroma and taste compounds. Aroma compounds will be identified using multidimensional gas chromatography coupled to mass spectrometry and olfactometry (MDGC-MS-O). Odor-odor interactions will be studied using olfactoscanning, in which a GC-O is coupled to an olfactometer.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;;; 195195;655950;EMPOWER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Empowering parents through the development of an online evidence-based mental health promotion school engagement resource;6/07/2015;5/07/2017;;The promotion of childrens mental health and wellbeing is fundamental to achieving strategic objectives of the EU health policy. Schools are recognised as a key setting to support and enhance childrens social and emotional wellbeing. Evidence to date indicates that school interventions have the greatest impact when they are focused on linking children, teachers and parents in the promotion of positive mental health. To date, however, there is an absence of research and resources to assist schools in supporting parental engagement in mental health promotion. The proposed research aims to address this crucial gap in school mental health. The study will adopt a systematic approach to developing an evidence-based resource for primary schools which is designed to assist school staff in establishing collaborative relationships with parents and align parent and teacher practices in promoting childrens mental health. In order to achieve this, the applicant will (i) systematically review current evidence on existing school-parent engagement frameworks and resources (ii) develop an online school-parent engagement resource based on the current evidence and consultation with school community stakeholders (iii) evaluate the implementation and efficacy of the online resource when implemented as part of a whole school mental health intervention that is being trialled in ten primary schools in Twente. This research will be carried out in collaboration with Prof Bohlmeijer at the Dept. of Psychology, Health and Technology and the Centre of eHealth Research and Disease Management at the University of Twente. The applicant will receive expert training from the Centre of eHealth Research in the development of technology supported mental health interventions. Under the guidance of Prof Bohlmeijer, the applicant will advance her research, management and networking skills and will generate an innovative research niche producing questions for investigation beyond the life of this study.;165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT TWENTE;NL;;; 195157;655699;Dietary biomarkers;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dietary biomarkers and compliance;1/09/2016;31/08/2018;;Justification of relationships between foods and health is significantly limited by lack of versatile and accurate analytical tools. Metabolomics has in a few years revealed many novel food intake biomarkers but only few of these markers have been validated and applied in clinical settings. The primary aim of the proposed work at Department of Nutrition, Exercise and Sports (NEXS) is to identify, validate and methodologically combine a large number of biomarkers, covering broadly common foods, beverages, and supplements to provide a robust and objective tool to assess recent dietary intakes. The dietary assessment tool will be thoroughly validated through application to fully dietary controlled studies and to studies where the current subjective instruments have been applied. My new objective tool will help compliance assessment in clinical trials, observational studies and in the care of patients with food-related disorders. This is timely because all current instruments are subjective and have major flaws when applied to e.g. causes of overweight and failing dietary interventions. The host institution has a strong background in metabolomics, biomarker development, human trials and studies of weight loss and is internationally highly recognized within the nutrition area. My proposal includes several innovative features for dietary assessment and analytics and through advanced training provides me ample skills acquisition such as advanced analytical method development, data analysis, statistics, networking, project management, etc. of major importance for my research career plans.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195131;655565;SMARTLAW;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Towards a regulatory framework for climate smart agriculture;1/01/2016;31/12/2017;;"Towards a regulatory framework for climate smart agriculture
Between now and 2050, there will be a sharp increase in the demand of agricultural products due to an increase of the worlds population, the rise in global calorie intake due to greater affluence, and the production of biofuels. The increase in agricultural production will be accompanied by an increase in the emission of greenhouse gasses. Agriculture is not only a major cause of climate change but in many regions of the world, it is also seriously impacted by climate change.
Policy documents, mostly by international institutions, have endorsed climate smart agriculture (CSA) as a means to achieve production growth, while at the same reducing the emission of greenhouse gasses and adapting the agricultural sector to the changing climate. However, it is as yet unclear through what regulatory mechanism CSA can be achieved. The key objective of this project is to identify the main elements of a regulatory framework that enables, facilitates and stimulates the transition of conventional farm practices toward climate friendly practices in the EU. Various methodologies will be used, such as an evaluation of the Australian Carbon Farming Initiative Act, to date the worlds only comprehensive regulatory instrument aimed at facilitating climate smart agriculture.
The project is aimed to be a stepping stone towards a more ambitious research proposal (to be submitted to the European Research Council (ERC) in 2017) aimed at developing the regulatory instruments needed to make the entire European agricultural sector resilient to the impacts of climate change. MSCA IF enables me to be heavily involved in climate law research for two full years, which will give a boost to my scholarly career and provides me competitiveness under the ERC.";177989,4;177989,4;H2020-MSCA-IF-2014;MSCA-IF-GF;STICHTING KATHOLIEKE UNIVERSITEIT BRABANT;NL;;; 195323;656778;Class II PI3K;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of the signalling and physiological roles of the class II PI3Ks;1/02/2016;31/01/2018;;"Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that generate intracellular second messengers in signal transduction and membrane trafficking pathways and are important drug targets. This proposal seeks to delineate the roles and mechanism of action of a group of PI3Ks which have remained enigmatic ever since their discovery over a decade ago.
The PI3K family comprises eight members in three subclasses. Class I PI3Ks signal downstream of growth factor and G protein-coupled receptors, are amongst the most commonly mutated genes in cancer and are being exploited as drug targets. The class II and III PI3Ks have in part emerged as regulators of membrane trafficking pathways but their physiological roles remain poorly understood.
We aim to identify the physiological roles of the class II PI3K-C2? and ? and to characterize the impact of their kinase activity on signalling pathways. To analyse the roles of class II PI3K activity in vivo, the Host Laboratory has created constitutive global and conditional knock-in kinase-inactive mice (unpublished). In contrast to PI3K gene knockout models, these mouse lines allow us to specifically address kinase-dependent functions and hence are an ideal model to evaluate the potential of class II PI3Ks as drug targets.
The class II PI3K-C2? (C2?) is involved in endo- and exocytosis as well as endocytic recycling, whereas PI3K-C2? (C2?) has been implicated in cell migration. However, their influence on cellular signalling is unknown. As an initial approach, the Host Laboratory performed a screen for proteins interacting with C2? or C2? (unpublished). We will explore hits from this screen using the kinase-inactive knock-in mice and cells derived thereof as discovery tools.
The combination of my expertise in membrane traffic and phosphoinositide regulation with the mouse and signalling studies of the Host Laboratory form an excellent and timely basis to uncover the roles of the class II PI3Ks in mammalian biology.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 194989;654731;ARD-West;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ancient Religious Dedications in the Western Mediterranean Basin;1/09/2015;31/08/2017;;"Ancient European cultural features are made up of epichoric creations, transfers and even local adaptations. Before Roman domination led to a new, centralised kind of cultural context, numerous peoples had developed their own cultural and identity codes through creation, adaptation and re-elaboration of concepts and objects. The goal of this project is to identify these processes of creation in Pre-Roman peoples' written expression. An innovative criterion has been chosen to accomplish this challenge, that is, the epigraphical genre (EG), whose definition through its material and textual elements (ME and TE) we have developed, and we will refine through this project. A particular kind of EG, the religious dedication (RD), is our starting point due to their wide diffusion and their significance in identity matters.
We believe that the epigraphical approach is idoneous to achieve this aim, given its holistic results and its multidisciplinar methodology. It also involves a direct analysis of the pieces, which contributes preserving European archaeological, linguistic and religious heritage. All the results will be stored in an updated, accesible online epigraphical DataBase of all the Pre-Roman and early Roman RD in the Roman West, which will facilitate knowledge transfer at all levels and on which our further research will be based.
The proposed interdisciplinary research combines the linguistic and socio-linguistic approach, led by Dr. Emmanuel Dupraz (the supervisor), with the historical/epigraphical perspective, provided by Dr. Mara Jos Estarn (the ER) at the Universit Libre de Bruxelles (ULB).";160800;160800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE LIBRE DE BRUXELLES;BE;;; 194965;654410;JERICO-NEXT;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;Joint European Research Infrastructure network for Coastal Observatory Novel European eXpertise for coastal observaTories;1/09/2015;31/08/2019;;"The coastal area is the most productive and dynamic environment of the world ocean with significant resources and services for mankind.
JERICO-NEXT (33 organizations from 15 countries) emphasizes that the complexity of the coastal ocean cannot be well understood if interconnection between physics, biogeochemistry and biology is not guaranteed. Such an integration requires new technological developments allowing continuous monitoring of a larger set of parameters.

In the continuity of JERICO(FP7), the objective of JERICO-NEXT consists in strengthening and enlarging a solid and transparent European network in providing operational services for the timely, continuous and sustainable delivery of high quality environmental data and information products related to marine environment in European coastal seas

Other objectives are: Support European coastal research communities, enable free and open access to data, enhance the readiness of new observing platform networks by increasing the performance of sensors, showcase of the adequacy of the so-developed observing technologies and strategies, propose a medium-term roadmap for coastal observatories through a permanent dialogue with stakeholders.

Innovation
JERICO-NEXT is based of a set of technological and methodological innovations. One main innovation potential is to provide a simple access to a large set of validated crucial information to understand the global change in coastal areas.
Although JERICO-NEXT already includes industrial partners, it will be open to other research institutes, laboratories and private companies which could become associated partners to the project.

Added values of JERICO NEXT
JERICO-RI shall send data and information in an operational mode to European data systems, with dedicated service access.
One of the strengths of JERICO-NEXT lies in the fact that technological and methodological developments shall be deployed in natural environment.";9998876,47;9998876,47;H2020-INFRAIA-2014-2015;RIA;INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER;FR;"EUROGOOS AISBL;SUOMEN YMPARISTOKESKUS;THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS;VLAAMS INSTITUUT VOOR DE ZEE VZW;EURO-ARGO ERIC;UNIVERSITA TA MALTA;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;MARIENE INFORMATIE SERVICE MARIS BV;SOCIB - CONSORCIO PARA EL DISENO, CONSTRUCCION, EQUIPAMIENTO Y EXPLOTACION DEL SISTEMA DE OBSERVACION COSTERO DE LAS ILLES BALEARS;HELLENIC CENTRE FOR MARINE RESEARCH;ILMATIETEEN LAITOS;SMARTBAY IRELAND LIMITED;INSTITUTE OF OCEANOLOGY - BULGARIAN ACADEMY OF SCIENCES;MARINE INSTITUTE;MINISTERIE VAN INFRASTRUCTUUR EN MILIEU;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;CONSIGLIO NAZIONALE DELLE RICERCHE;UNIVERSITAT POLITECNICA DE CATALUNYA;SLR ENVIRONMENTAL CONSULTING(IRELAND)LIMITED;NORSK INSTITUTT FOR VANNFORSKNING;FUNDACION AZTI - AZTI FUNDAZIOA;BLUE LOBSTER IT LIMITED;ETT SPA;FONDAZIONE CENTRO EURO-MEDITERRANEO SUI CAMBIAMENTI CLIMATICI;HAVFORSKNINGSINSTITUTTET;HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH;SVERIGES METEOROLOGISKA OCH HYDROLOGISKA INSTITUT;ISTITUTO NAZIONALE DI OCEANOGRAFIA E DI GEOFISICA SPERIMENTALE;DURAND DOMINIQUE, DENIS, FABRICE;FLUIDION;STICHTING DELTARES;INSTITUTO HIDROGRAFICO;INTERNATIONAL RESEARCH INSTITUTE OFSTAVANGER AS";"BE;FI;UK;FR;MT;ES;NL;EL;IE;BG;IT;NO;DE;SE;PT"; 195104;655416;UltraTherMicroscope;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;Ultra-sensitive Thermal Nanoscale Microscope;1/04/2015;30/09/2016;;The research and commercialization of nanotechnology-based products require continuous development of advanced nanoscale inspection tools that drive the high-resolution microscopy markets. The state-of-the-art (SoA) microscopy provides a broad range of physical, spectroscopic, and materials characterization means, however, one of its key deficient ingredients is nanoscale thermal imaging an essential tool for failure analysis and characterization of local heating and energy loss sources in high-density electronic nanodevices under operational conditions. The goal of this project is to provide a proof of concept (PoC) for a ground-breaking nanoscale thermal sensor and high-resolution scanning imaging system reaching thermal sensitivity with up to three orders of magnitude improvement over the existing SoA. The PoC aims at determining the technological feasibility and establishing commercialization potential for high sensitivity and high bandwidth nanoscale thermal imaging of operating devices in microelectronics, quantum computing, and novel materials industries. The project comprises benchmark demonstrations, patenting, development of relevant business models, and networking actions for successful commercialization. The novel sensor and microscopy system will serve as cost efficient application in materials research, failure analysis, and process control. It is thus expected to contribute to the competitiveness of Europes important Key Enabling Technology sector in Materials Science and Nanoindustries.;150000;150000;ERC-2014-PoC;ERC-POC;WEIZMANN INSTITUTE OF SCIENCE;IL;;; 195180;655854;Syncrip_2014;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The molecular basis of learning and memory: uncovering the link between neuronal activation and localized translation at the synapse.;1/09/2015;31/08/2017;;"During learning specific neuronal connections are strengthened and weakened to create long-term memory. This requires local regulation of the availability of proteins at the synapse, at a large distance from the cell body, in response to neuronal activity. It is generally recognized that such synaptic plasticity can be achieved through the regulation of translation of localized mRNAs at or near the synapses. Despite the importance of this mechanism in memory and our understanding of neurodegenerative diseases, the molecular basis by which neuronal activation regulates localised translation is still largely unknown in any system.

I propose to address this deficiency by discovering the key regulatory pathway in activity dependent synaptic plasticity in the Drosophila third instar motorneuron synapse, a well established model for generalised synaptic function. My proposal is built on extremely promising unpublished observations showing that a highly conserved mRNA binding protein, Syncrip (Syp) regulates the localized translation of key synaptic mRNAs, such as the conserved scaffolding molecule Discs large, at the motorneuron synapse, in response to neuronal stimulation. Preliminary data from the lab suggests that Syp is post-translationally modified by Calcium/calmodulin-dependent protein kinase II (CaMKII), a well-known kinase that plays essential and conserved roles in memory. I propose to test the hypothesis that binding of Syp to its mRNA targets is regulated by phosphorylation by CamKII. I will test whether Syp is phosphorylated at CamKII consensus sites located in its mRNA binding domains, which have been modelled on the human structure. We will use mass spectrometry to identify these phosphorylation sites and characterise phosphorylation mutants of Syp generated by CRISPR. I also aim to discover the molecular mechanism by which Syncrip regulates the translation of its targets.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195142;655621;MUGNAIO;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;MUltiplex Government Networks Analysis and InvestigatiOn;1/07/2015;;;"Multiplex networks are networks where multiple different types of nodes and relations are studied together. Multiplex network analysis is a growing branch of network science, with contributions from both mathematics/physics, looking for the defining statistical mechanics of multiplex networks, and computer science, aiming at using multiplex networks to represent and analyze complex real world interacting phenomena.
In this proposal, the researcher will exploit a recently collected dataset extracted from the government websites of the states of the US, which allows a multiplex network representation of a government. The main aim of the research plan is to understand how governments work, how they scale and speciate their agencies covering more complex tasks, and how they relate to the society in which they are embedded.
A wide range of techniques will be applied, from the detection and comparison of functional topical modules inside government networks, to the creation of government activity complexity measures. This research is expected to have externalities in how we understand government activities, potentially impacting the efficiency of public actions on society. A public observatory including the results of the research, along with visualizations and data release, will be shared with the public, empowering citizens with a better understanding of the agencies governing their lives.
Under this plan, the researcher, whose background is mainly in computer science, will be exposed to a mathematical approach to multiplex network analysis, and he is expected to increase his proficiency in this aspect. As a result, he is expected to become an all-around multidisciplinary network scientist, improving over his previous pioneering work on the computer science side of multiplex networks. The host institution has been chosen as one of the leading and fastest growing groups";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;QUEEN MARY UNIVERSITY OF LONDON;UK;;; 195318;656760;BioEnergyTrain;SIGNED;H2020-EU.3.3.6.;LCE-20-2014;H2020;BioEnergyTrain;1/05/2015;30/04/2019;;The development and adoption of renewable and sustainable energy has become a top priority in Europe, and is Horizon 2020s most prominent theme. Research into new energy methods required to reduce humanitys carbon footprint is an urgent and critical need, and is reliant upon a flow of newly qualified persons in areas as diverse as renewable energy infrastructure management, new energy materials and methods, and smart buildings and transport. Bioenergy is a particularly important field in this respect as it is at the cross-roads of several important European policies, from the Strategic Energy Technology Plan Roadmap on Education and Training (SET-Plan) to the European Bioeconomy Strategy to European Food Safety and Nutrition Policy. European development in this prioritised field is stalled due to a lack of qualified personnel, a lack of cohesion and integration among stakeholders, and poor linkage between professional training and industry needs. To address these problems, BioEnergyTrain brings together fifteen partners from six EU countries to create new post-graduate level curricula in key bioenergy disciplines, and a network of tertiary education institutions, research centres, professional associations, and industry stakeholders encompassing the whole value chain of bioenergy from field/forest to integration into the sustainable energy systems of buildings, settlements and regions. The project will foster European cooperation to provide a highly skilled and innovative workforce across the whole bioenergy value chain, closely following the recommendations of the SET-Plan Education Roadmap.;3697580;3697578,75;H2020-LCE-2014-2;CSA;EUROPEAN SUSTAINABLE ENERGY INNOVATION ALLIANCE - ESEIA, VEREIN FUR FORDERUNG DER EUROPAIESCHEN INNOVATION FUR ERNEUERBARE ENERGIEN;AT;"TECHNISCHE UNIVERSITAET GRAZ;ECO WORLD STYRIA UMWELTTECHNIK CLUSTER GMBH;BRP-POWERTRAIN GMBH & CO KG;ELES DOO SISTEMSKI OPERATOR PRENOSNEGA ELEKTROENERGETSKEGA OMREZJA;UNIVERSITEIT TWENTE;Laboratorio Nacional de Energia e Geologia I.P.;KOMPETENZZENTRUM HOLZ GMBH;BERGISCHER ABFALLWIRTSCHAFTSVERBAND;UNIVERZA V LJUBLJANI;LANDESENERGIEVEREIN;KIC INNOENERGY SE;UNIVERSITATEA TRANSILVANIA DIN BRASOV;ENERGIE AGENTUR STEIERMARK GEMEINNUTZIGE GMBH;ASOCIATIA ""GREEN ENERGY"";TECHNISCHE UNIVERSITAET HAMBURG-HARBURG";"AT;SI;NL;PT;DE;RO"; 195116;655480;MuMoSiSt;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multidisciplinary approach to multilayer monumental sites studies: the case of the Quirinal Hill in Rome;1/09/2015;31/08/2017;;The multiplicity of different historical phases can be considered one of the most singular characteristics of cultural heritage. Until today it has been clear that the scientific approach to this issue should use the developmental process as the main tool for both defining the historical phases and understanding the current state of historical heritage. Generally, it is necessary to distinguish between the diachronic and the synchronic studies, but at the same time it is mandatory to evaluate the connection between different historical layers. These opposing needs still represent a big problem that historical sciences are not always able to manage. The desirable multidisciplinary approach often produces mediocre results, while individual research generally lacks the complexity that always characterizes conservation and valorisation issues. Thus, the research project aims to discover a methodological approach that can bridge the gaps that are now often apparent between different studies. The main research goal is to define a specific digital platform for the management and consulting of the outcomes provided from the different scientific fields involved. This structure will allow to share the data collected easily, giving information about the different historical phases of a site as well as a global assessment based on its most significant transformations. The area of the ancient Temple of Serapis on the Quirinal Hill in Rome should be a good case study, that's mainly because of its complex stratigraphy. The research aims at covering the whole development period of the area by means of systematic data collection. The analysis of all different temporal phases will be fundamental for the implementation of a methodological strategy, able to involve different experts. The benefit of a web accessible digital platform able to collect all the diverse data, would be evident in the final step, when digital drawings based on new multimedia technologies will be produced.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HUMBOLDT-UNIVERSITAT ZU BERLIN;DE;;; 195031;655009;KOPAR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Knowledge Publishing, Acquisition and Representation;6/07/2015;5/07/2017;;"The KOPAR project aims to investigate the inclusive nature of scientific documents from an integrative-interoperable semantic perspective. Scientific publications aggregate data by encompassing it within a persuasive narrative. Such aggregation is highly federated as authors reference external sources, analyze data elsewhere and summarize over the document, archive and publish methods, data and processes over heterogeneous resources and using a myriad of formats. KOPAR addresses the problem of supporting such aggregation over a document that is to be born semantic, interoperable and conceived as an aggregator within a web-of-data publishing workflow; KOPAR delivers the tooling necessary for authors to generate this type of documents. Existing ontologies, data structures, standards and Application Programing Interfaces are brought together in order to facilitate the assemblage, identification and characterization of these arrangements in the document. Conceptual elements such as Research Objects, nanopublications, references, experimental protocols and data are to be logically assembled within the document as self-describing, machine procesable elements. KOPAR will deliver a novel paradigm for scholarly communication, one that makes it possible to understand the paper as an aggregator, a living document that is both an interface to the Web of Data as well as the pivot for collaboration across scientists.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD POLITECNICA DE MADRID;ES;;; 195167;655764;HQSTS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High-Quality voice model for STatistical parametric speech Synthesis;1/10/2015;30/09/2017;;A speech analysis/synthesis method aims at representing a speech waveform, produced by a person speaking, as a time sequence of parameters. Based on this time sequence, the speech waveform can be resynthesized. The analysis/synthesis methods are cornerstones for many speech technologies (e.g. text-to-speech, telecommunications, voice restoration). For the majority of applications, these methods need to have two key properties: (i) a high perceived quality of the speech sound, and, (ii) a statistical characterization of the parameters' sequence necessary for statistical approaches, which have attracted great interest during the last decades in speech technologies. The current analysis/synthesis methods that provide a statistical characterization exhibit however a lack of perceived quality. This issue does not pose a problem in applications designed for noisy environments (e.g. navigation devices, smart-phone applications, announcements in train stations). On the contrary, it prohibits the use of statistical approaches in quiet environments, e.g. in the music, cinema and video game industries, where the listener is fully aware of all the details of the sound. This problem is mainly due to the lack of an accurate representation of the phase information and its correlation with the amplitude information. Indeed, recent phase processing tools allowed the description of the phase spectrum properties in a way that shows the drawbacks and limits of current analysis/synthesis methods. Additionally, these same tools are also promising means for modeling the phase information, which is paramount for good quality. The primary goal of the HQSTS project is to create a high-quality analysis/synthesis method that will broaden the applications of statistical approaches of speech technologies in quiet environments, where a high-quality is an absolute necessity.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195050;655119;MycoTest;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of fast antibody-based screening tests for the detection of harmful mycotoxins in food and feed;1/10/2015;30/09/2017;;The contamination of food and feed with harmful fungal derived mycotoxins is a problem worldwide and worsening. Over 400 different mycotoxins are now known, some of them have been studied in great detail, while the data about toxicity and occurrence for many others are scarce. This information is required to determine the risk in relation to animal and human health and establish maximum permitted levels that do not pose any health concerns. The fast elimination of contaminated food and feed from the supply chain is crucial for the protection of human and animal health as many of these toxins can cause serious diseases both after acute and chronic exposure. The occurrence data cannot be provided without fast and reliable detection methods that allow quantification of these toxic contaminants. This research, therefore, is focused on delivering new fast antibody-based (ELISA) screening methods for the detection of three important mycotoxins: T-2/HT-2, ochratoxin A and sterigmatocystin and on the development of a first multiplex flow-through rapid (FTR) test for the simultaneous detection of mycotoxins in food and feed. These tests could be used by food and feed producers, importers and testing laboratories to assure food and feed safety on the European market. The researcher will work for two years with the food safety company EuroProxima (EP) in the Netherlands that will provide training and support of the development of the commercial analytical assays. The project will be also supported by the partner organisations - Institute for Global Food Security (IGFS) at Queen's University Belfast (QUB) and RIKILT Wageningen UR (RIKILT) who will be hosting secondment phases in order to facilitate the work packages. This project aims to combine academic excellence with specialist SME know-how to work on a project with significant impact on public health and that offers a substantial commercial opportunity.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPROXIMA;NL;;; 195051;655134;SOS-Nano;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structure Oxidative Stress relationships of metal oxide nanoparticles in the aquatic environment;1/11/2015;31/10/2017;;"The SOS-Nano project will address one of the most pressing cutting edge issues of econanotoxicology at present: to find a structural property of nanoparticles (NPs) to predict their potential toxicity in real aquatic environments, the final sink of released NPs. By using an in vivo natural water exposure system, SOS-Nano will test the suitability of two paradigms, recently demonstrated effective in vitro for ranking the hazard of metal oxide NPs: 1) NPs physical-electrochemical properties for predicting oxidative stress potential, and 2) oxidative stress generation for predicting biological impact.
The experimental plan of SOS-Nano is totally innovative for design and methodology: the relationships between NPs structure and toxic activity will be studied under the influence of natural water properties, and the toxic potential will be ranked through a multi-tier system combining genomics and functional measurements.
The science of SOS-Nano will have high impact: nanotechnology is one of the six EU Key Enabling Technologies selected by the EU Commission to address the industrial-economic competitiveness and the grand societal challenges in Europe by 2020 (US$ 2.5 trillion of world market, 2 million of employers by 2015). The lack of a sound human and environmental risk assessment of NPs is now the major limitation to the safe growth of this economic sector, and the EU research community is tasked with addressing the nanotechnologies development toward sustainability.
The SOS-Nano project will represent the perfect opportunity for the applicant to join a cutting edge working environment in which she will realise her potential as a leading nanosafety expert in EU. The host Institution, the University of Exeter, is in the top 10 UK Universities which will provide exciting opportunities for gaining interdisciplinary experience of novel approaches in ecotoxicology and for networking with industry and international partners at the forefront of environmental nanoscience.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EXETER;UK;;; 195307;656658;NanoCuI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Nano-Copper Iodide: A New Material for High Performance P-Type Dye-Sensitized Solar Cells;3/09/2015;2/09/2017;;p-Type dye-sensitized photocathodes (p-DSSCs) are a new type of solar energy device. They promise to increase the efficiency of dye-sensitized solar cells (DSSCs) by enabling tandem cells that absorb light at both electrodes, in similar fashion to multi-junction semiconductor PV. However, no component of the p-DSSC is fully optimised, and the nickel oxide (NiO) substrates used as the p-type semiconductor appear to be a particular weak point, due to their inefficient charge transport. In this project, we will develop new copper(I) halide electrodes which transport charge much better, and will potentially form the heart of new, efficient p-DSSCs.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF EAST ANGLIA;UK;;; 194968;654467;HierTough;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hierarchical composites for improving toughness: modelling and experimental validation;17/08/2015;16/08/2016;;Carbon fibre-reinforced polymers (CFRPs) are a rapidly growing class of materials as they possess excellent stiffness and strength in combination with a low density. They are vital in reaching the European objectives to reduce emissions of greenhouse gases and to achieve more efficient material usage . They are becoming highly popular in aerospace and automotive industries, but their introduction is hampered by their low damage tolerance. This fellowship proposes a novel approach to increase the toughness and hence the damage tolerance of CFRPs by intelligently designing the microstructure of the material in a hierarchical manner. The objective is to predict the microstructure that maximises toughness through modelling, to manufacture this microstructure and to validate the predicted toughness experimentally. The translaminar fracture toughness of CFRPs is expected to be increased by 50-100%. This is realistic given the successful examples from nature as well as recent, but preliminary modelling predictions. The fellowship will benefit from synergies between the models developed by the experienced researcher during his PhD and by the supervisors group. An extensive and multidisciplinary framework of materials, mechanics and chemistry is uniquely available at Imperial to help to reach the objectives. The outcome of the project will help the EU to gain a competitive edge in the aerospace and automotive industries.;91727,4;91727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195114;655475;JELLYPACTS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Assessment of Jellyfish Socioeconomic Impacts in the Mediterranean: Implications for Management;1/09/2016;31/08/2018;;"Social and scientific concern about jellyfish (JF) blooms has risen over the past decades. This concern is reflected on the number of reports on JF; since 1941 the number of scientific publications on JF has doubled each decade, whilst news reports have increased by over 500% over the past two decades. Aggregations of JF can cause multitude of problems for different sectors of society; including the fishing industry and tourism. There is no doubt that the combination of a growing human population and the increasing use of the marine environment will lead to higher encounter rates between JF and humans. To add to the concern, there has been a heated scientific debate on whether JF populations might be on the rise. However, regardless of whether JF populations are increasing, there are no easy solutions to manage all the problems associated with JF blooms. Therefore, there is an urgent need to focus research objectives towards understanding the potential of a suite of management strategies to tackle current impacts of JF over ecosystem services. There are many existing strategies for managing JF blooms however, these are mostly economically expensive and thus, there is a need to evaluate whether the costs of implementing particular management policies will offset the costs of JF impacts. In order to device cost-effective management strategies, a focus on the interdisciplinary nature of JF impacts that includes ecological, social and economic aspects such as the associated loss of peoples wellbeing is of critical importance. Unfortunately, there is a knowledge gap on the socioeconomic impacts of JF and estimates are sparse and qualitative. The project proposed here has the overall goal to further the knowledge of the existing interactions between jellyfish and society by assessing the economic and social impacts stemming from their presence and the integration of this newfound knowledge into adaptive management policies.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 194974;654495;MUIMME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;MILK BANKING AND THE UNCERTAIN INTERACTION BETWEEN MATERNAL MILK AND ETHANOL;1/04/2015;31/03/2017;;Donor human milk banks are expanding around the world at an exponential rate, which is directly linked to global increases in premature births. The importance of human milk for prematurely born infants has been extensively identified, even among the recent social scientific work that has questioned the efficacy of human milk and health considerations. In addition, research also shows that a significant percentage of these mothers, at least initially, experience lactation problems. Europe is taking a leadership role in expansion of human milk banks, although issues associated with alcohol consumption and maternal donations are a concern for clinicians and health care staff, given the increasing problems associated with drinking among women of childbearing age. Europe with the highest alcohol per capita consumption rates in the world, makes these issues particularly immediate. The United Kingdom (UK) with its long history and current global leadership role is an ideal place to study these considerations which will inform these larger issues of human milk for the prematurely born infant. A leader in this century old intervention, supporting not only one of the oldest hospital based banks in Europe, but also an important cross-border collaborations on the island of Ireland, along with a research based national bank in Scotland, each representing different cases contributing significantly to the re-birth of the medical control of human milk. The UK is poised to offer the world vital information regarding donor human milk banking, maternal bodies and trust, an important sociological social theoretical concept which will be used to frame the triangulated data collected for this project (including interviews, archival data, and ethnographic information). Supporting an excellent experienced female researcher to return to the academy following a maternity/career break, this project directly supports women and science in society. MUIMME is an old Irish word for wet-nurse.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITY OF CENTRAL LANCASHIRE;UK;;; 195089;655310;LDMRD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Large Deviations and Measure Rigidity in Dynamics;1/09/2015;31/08/2017;;The proposition aims to develop new tools in ergodic theory and dynamical systems, and explore applications to problems related to mathematical physics, geometry and arithmetics. The first general objective is to advance large deviation theory for non-compact dynamical systems. We plan to deduce new subexponential large deviation bounds for Gibbs measures on the countable Markov shift and explore how these results are linked to applications such as Pomeau-Manneville dynamics describing intermittence in the theory of turbulent flows, dynamical properties of the Gauss map, which is deeply connected to Diophantine approximation, and homogeneous dynamics such as the Teichmller flow on translation surfaces. The second general objective is to investigate Host-type measure rigidity theory for toral automorphisms and homogeneous dynamics. This topic relates to currently ongoing research on measure classification theorems, which have been influential in several applications such Diophantine approximation and quantum ergodicity.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 194950;654213;STR- ESFRI;SIGNED;H2020-EU.1.4.3.1.;INFRASUPP-5-2014;H2020;Support to Reinforce the European Strategy Forum for Research Infrastructures;1/03/2015;28/02/2019;;"'A 4 year 'Coordination and Support Action' project led by the Science Technology Facilities Council (UK) in partnership with Universita degli Studi di Milano, (Italy), ATHENA Research and Innovation Centre, (Greece) and German Aerospace Center, DLR (Germany).

The goal of STR-ESFRI is to provide support to reinforce the European Strategy Forum for Research Infrastructures (ESFRI) under the guidance of its Chair, by providing additional resources, tools and expertise for performing its activities and supporting its structures.

The main objectives of this project are to provide support to the ESFRI Chair in all ESFRI related activities, to support the process for delivery of the new ESFRI Roadmap, to disseminate and exploit ESFRI related outputs to the European and Global Research Infrastructure Area, liaise with key stakeholders including the e-Infrastructure Reflection Group (e-IRG), to identify best practices and facilitate the exchange of experiences among ESFRI projects and other European and Global Research Infrastructures and finally to monitor projects on the ESFRI roadmap.'";1999983,75;1999983,75;H2020-INFRASUPP-2014-2;CSA;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;UK;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;ATHENA RESEARCH AND INNOVATION CENTER IN INFORMATION COMMUNICATION & KNOWLEDGE TECHNOLOGIES;UNIVERSITA DEGLI STUDI DI MILANO";"DE;EL;IT"; 195165;655760;DIGIPHASE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of Maximum Efficiency Phase Contrast Electron Microscopy;1/07/2015;30/06/2017;;Electron microscopy is a key technique for imaging and analysis of materials. Although aberration correction has made atomic resolution possible at low accelerating voltages, beam damage remains a critical limitation for many types of materials. The imaging modes currently in use today are inefficient in terms of the number of transmitted electrons detected and the way in which these are used to derive information. Current detectors integrate over details in the angular distribution of scattered intensities, and make use of only a limited range of scattering angles. In the case of scanning transmission electron microscopy (STEM), a wealth of information is contained in the distribution of electron scattering as a function of the illuminating probe position. The proposed work will make use of pixelated detectors to record this four-dimensional data set and develop methods to intelligently utilize the information it contains. This research project has become possible through recent advances in the sensitivity and speed of pixelated detectors, and offers a new path to maximize the information gained per fast electron. Maximum efficiency phase contrast imaging in STEM recovers the full amplitude and phase components of the specimen, with minimum dose, and maximum signal to noise ratio, and maximum contrast that does not require aberrations. In materials science for example it will enable imaging of charge transfer at point defects and interfaces while simultaneous Z-contrast imaging provides interpretability and chemical sensitivity. Similarly, such high sensitivity phase detection will allow the direct imaging of local electric and magnetic fields at the highest possible spatial resolutions, providing many new opportunities for understanding electronic, spintronic and magnetic materials at the heart of todays technological advances. In biology, maximum efficiency phase contrast imaging may open the door to the ultimate low dose molecular- and bio-imaging.;166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195303;656724;InterDemo;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Intercultural Democracies: insights from mining conflicts for environmental justice in plurinational Bolivia and Ecuador.;1/10/2015;;;"Claims from hitherto excluded indigenous groups have led to the rewriting of constitutions in Bolivia and Ecuador to recognize intercultural democracy. At the same time, indigenous environmental justice movements have increased their contestation of hydrocarbon extraction and recently mining due to their socio-political and ecological impacts. Analysis of these movements to date has focused on the consequences of conflicts, but less so on their socio-political and ecological drivers. While evidence has demonstrated the role of an increasing social metabolism as a driver of extraction, less attention has been paid to power relations and competing socio-political forces. These deeply influence the possibilities for a democratic control of the extractive sector, a crucial factor for achieving environmental justice and sustainability.
This research aims to unpack the power relations that lie beneath the biophysical flows of expanding resource extraction in the intercultural democracies of the Andes. Two mining-related conflicts in Cuenca Poop (Bolivia) and Intag (Ecuador), where indigenous organizations claim greater environmental justice specifically through self-determination as part of intercultural democracy, will be analyzed applying mixed methodologies: quantitative analysis of biophysical flows and qualitative analysis of interviews and data. This research will potentially show how ecological and metabolic drivers limit indigenous groups democratic participation through multi-scale power relations around resource appropriation, thereby improving the understanding of the political dimensions of these conflicts and informing more sustainable policies for extractive sectors. Training at the host institution (ICTA) will facilitate this research by complementing the candidates knowledge of political theory with skills in metabolic analysis and the interdisciplinary approach to environmental justice that forms the basis of ICTAs world-renowned research.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT AUTONOMA DE BARCELONA;ES;;; 195101;655396;COPAST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Colours of the Past in Victorian England;1/03/2016;28/02/2018;;This project entitled The Colours of the Past in Victorian England (COPAST) aims to analyse the reception of the chromatic material culture of Antiquity and the Middle Ages in the works of writers and painters from William Morriss close circle. These politically-committed poets and artists looked towards the ideologically-charged colours of Hellenic and medieval arts and crafts, in order to retrieve and emulate supposedly more meaningful hues and dyeing processes which they believed modern science and economic imperatives had stripped of their symbolic and artistic value. The Victorian age (1837-1901) was indeed a turning point in terms of scientific discoveries of new chemical colours, including coal-tar based synthetic dyes. Dr. Ribeyrol will investigate ideological approaches to ancient polychromy in the context of the Greek and Gothic Revivals which affected industrialized England in the second half of the 19th century. Using close analysis of art works, literary texts and pigment recipe books, she will contrast these ancient hues with the new chemical aniline dyes which were mainly devised for the expanding textile industry. This innovative focus on chromatic materiality in the field of Victorian art history and literature will enable her to shed light on the artistic impact of this colour revolution which radically unsettled the way certain avant-garde Victorian writers and artists related to chromatic terminology and used traditional, organic pigments.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195127;655537;RAVE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Rotifers as Vehicles for Epibiotic Bacteria;1/06/2015;31/05/2017;;Non-trophic species interactions such as epibiosis are poorly studied and their impact on food web properties not easily quantified. Using rotifers and their attached bacteria, this project analyses two hypotheses on epibiosis in freshwater systems. (1) Epibiont-derived organic carbon is transported to the predators together with the host and forms a shortcut through the food web from dissolved organic carbon to higher predators. (2) Potentially pathogenic bacteria can attach to zooplankton and migrate with them, dispersing through great distances to areas that are considered pristine. The project follows a bottom-up approach from experimental assessments of the uptake of single cells attached to rotifers to the statistical inference on the effects of rotifer and bacterial communities. The questions are addressed by state-of-the-art methodologies, (tracer uptake, chemostat experiments, next generation sequencing and statistical models) by combining the expertise of a microbial ecologist (the experienced researcher, ER) and an evolutionary ecologist working on animals (the host). The study will be the first one to quantify the impact of epibionts on carbon transfer to higher trophic levels and the host-mediated distribution of bacterial genotypes in nature. The cross-disciplinary training of RAVE will considerably distinguish the ER from other microbial ecologist and prepare her for a further career in the field of microbe-zooplankton interactions.;168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195016;654917;BiBiCrossLang;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Language activation and control in the unimodal and bimodal bilingual lexicon;1/07/2015;30/06/2017;;Bilinguals activate words from both languages when listening, reading or speaking in one language, and engage non-linguistic cognitive control abilities to resolve cross-linguistic competition. Most studies of cross-language activation have focused on activation between languages through overlapping phonological representations. However, cross-language activation also occurs in deaf or hearing bilinguals who are familiar with a spoken language and a sign language, two languages without overlapping phonological systems. The proposed research aims to systematically investigate phonological and lexical-semantic contributions to cross-language activation during production and comprehension by studying and comparing cross-language activation patterns in three groups of bilinguals: (1) bilinguals with two spoken languages, and (2) hearing and (3) deaf bimodal bilinguals. Four studies are proposed that combine behavioural, eye-tracking and electrophysiological techniques to examine whether and how the availability of same-modality vs. different-modality phonological systems differentially modulates the nature of cross-language interaction and the recruitment of cognitive control mechanisms during bilingual production and comprehension. By including deaf as well as hearing bimodal bilinguals, the studies will furthermore provide critical insight into the linguistic mechanisms underlying cross-language activation between a spoken language and a signed language, and significantly advance bilingual approaches to language acquisition and processing in deaf readers.;170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE;ES;;; 195152;655667;ISOTRAPSS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Isoform specific inhibition by transient protein state stabilization;15/09/2015;14/09/2017;;"The rapid identification of synthetic molecules that selectively inhibit some proteins among families of closely related proteins is one of the major unsolved problems of modern drug discovery. If such ability was at hand, it would radically revise our definition of the druggable genome.

The goal of this proposal is to expand the state-of-the art of rational drug design with a new strategy that combines cutting edge computational techniques with modern experimental biophysical methods. We aim to achieve selective inhibition of proteins that are highly similar to other related proteins. To do so we will exploit concepts from energy landscape theory to identify transient conformational states of proteins that can be trapped by ligands to achieve extremely high binding selectivity.

To provide proof of concept for such strategy, we will focus efforts on the therapeutically relevant cyclophilin protein family. Computational work will focus on: 1) unravelling the conformational preferences of the most common cyclophilin family members, and 2) clarification of current controversies regarding the binding mode and structure activity relationships of known selective ligands. Experimental work will involve the characterization of purchased or custom-synthesized ligands in in vitro assays and crystal structure analyses.

Overall, this project proposes fundamental advances in rational drug design, therefore expanding opportunities for the development of future small molecule therapeutics.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195035;655026;MENTAL IMAGERY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The power of imagination Breaking through behavioural avoidance in depression with mental imagery;1/04/2016;31/03/2018;;Mental imagery is the ability of humans to visualize experiences or events in the mind. Mental imagery has recently successfully been applied as a therapeutic tool to treat dysfunctional cognitive processes underlying depression. Besides cognitive dysfunctions, people with depression also have difficulties in engaging in simple behavioural activities such as going outside or meeting friends. I argue that mental imagery can not only enhance cognitive aspects but also the behavioural problems people with depression face by drawing from established behavioural activation treatment principles. This central claim is founded in basic research showing that visualizing oneself engaging in a specific behaviour increases the chances of actually acting out this behaviour. The main research aim is to experimentally test the effects of mental imagery of approach behaviour on activity levels, mood and depressive symptoms in mildly depressed individuals. In an experimental study, participants will be randomized to a training condition or a control condition: the training consists of daily mental imagery of behavioural activities for 7 days and builds on previous ground-breaking work of researchers at the Medical Research Council (MRC) Cognition and Brain Sciences Unit in Cambridge where I will conduct the study. By working closely together with the supervisor at the host institution, prof. Emily Holmes, the fellowship will enable me to gain new knowledge and to deepen my background and expertise in experimental research designs. I will further broaden my research supervision and management skills through participation in staff development courses offered by the MRC in Cambridge. This newly acquired transferrable knowledge will form the backbone of a future grant application that I will prepare in collaboration with the supervisor towards the end of the fellowship.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 195293;656598;FASTQUANTUM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Ultrafast Sepctroscopy of Quantum Structures;19/08/2015;18/08/2017;;Nanoscopic or microscopic structures with their physical properties strongly affected by confinement effects are called quantum structures. This proposal aims for the investigation of ultrafast dynamics in different kinds of quantum structures, namely, semiconductor nanocrystals and metal nanoparticles, their combination to complex nanohybrids, nanowires, nanosheets, as well as nanoemitters in optical cavities. The high-quality quantum structures have been fabricated and already optically investigated by the applicant and his co-workers. These successful experiments delivered important results, but they did not allow for the investigation of the dynamics on a time scale below several picoseconds. On this short time scale, however, multiexciton and exciton relaxation dynamics, phonon dynamics, trapping to surface or defect states, non-radiative recombination, or stimulated emission occur, all determining the optical properties of the quantum structures. It is proposed to perform ultrafast laser spectroscopy on these structures in the expert research group of Prof. Kambhampati at McGill University, Canada. Here, unique spectroscopic facilities exist to investigate the relevant dynamics. Two kinds of experiments will be performed, which will also train the applicant in cutting-edge ultrafast spectroscopy techniques. Firstly, state-resolved transient absorption measurements will directly access the ultrafast dynamics. Secondly, novel two-dimensional electronic spectroscopy will deliver insights into ultrafast coherent processes of the quantum structures. The understanding of the fundamental ultrafast processes will help to further improve the quantum structures and to further pave the way for their application in optical or opto-electric devices.;164541,6;164541,6;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITAET HAMBURG;DE;;; 195036;655027;AutophagosomeSealing;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Ymr1 role in the Atg proteins release from complete autophagosomes;1/10/2015;30/09/2017;;Autophagy is one of the major intracellular degradation processes and it is essential for cell survival in multiple stress conditions. As a result, this pathway plays a key role in the pathophysiology of numerous illnesses including neurodegenerative, cardiovascular, chronic inflammatory, muscular and autoimmune diseases, and some malignancies. Structures targeted to destruction such as protein aggregates, organelles and invading pathogens are sequestered into double-membrane vesicles called autophagosomes. Autophagosomes are formed through the concerted action of the autophagy-related (Atg) proteins at a site specialized location known as the phagophore assembly site (PAS). Despite this knowledge, the mechanism and regulation of autophagy remain largely unknown. The host laboratory has found that Ymr1, a phosphatase dephosphorylating phosphatidylinositol-3-phosphate, plays a key role in the regulation of autophagy. The main objective of this project is to elucidate the mechanism through which Ymr1 regulates autophagy. To achieve this goal, the applicant will exploit the experimental advantages of the yeast model and use in combination cutting-edge techniques in molecular biology, biochemistry, fluorescence microscopy and electron microscopy. The results will advance our knowledge on autophagy and in a long-term perspective they will provide the conceptual bases for the development of therapies or compounds aimed to regulate autophagy to the benefit of human health. Through the realization of the project, the applicant will strongly reinforce his professional maturity, diversity and independence, essential for starting his own research activity.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ACADEMISCH ZIEKENHUIS GRONINGEN;NL;;; 195099;655379;Art and Brain;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Art and Brain: An integrated approach to causative analysis of neural function in perception of art using Transcranial Magnetic Stimulation;1/07/2015;30/06/2017;;This project will bring Matthew Pelowski to Vienna University to undergo a unique two-way program of knowledge transfer and to conduct an innovative, integrated behavioral/neural study of art perception using causative brain manipulation via TMS (Transcranial Magnetic Stimulation). Art is a unique feature of human life. Uncovering how it affects us requires joint expertise in aesthetics, psychology and neuroscience. Employing TMS, we will systematically manipulate three key brain regions (prefrontal, temporal and parietal), while individuals view a selection of art. Cognitive, emotional and evaluative reactions will be recorded via specially designed survey and assessed via a cognitive model which integrates these factors, both of which were created by Dr. Pelowski and which he will introduce to the Vienna group. Simultaneously, Dr. Pelowski will be supported by leading experts in arts neural study under guidance of host Dr. Leder, and will receive training in TMS. By comparing responses to a control and using Dr. Pelowski's methodology, we will collect a comprehensive within-subject dataset of specific impact of brain regions on art experience. This research will provide the next step for clarifying previous cognitive and neurological findings, achieving their integration. It will clarify general questions of brain role in emotion and evaluation. It will also have wide inter-sectoral application to dementia research and art therapy, which will be explored with experts in Leders group, and will be a breakthrough to future study of integrated neuroaesthetics and psychology of art. This project will also create a new research direction, expanding from an established center at University of Vienna, continuing a key tradition in empirical aesthetics. It also creates a point of continuing collaboration between Vienna, US and EU, and will further launch the career of Dr. Pelowsk and extend his proficiency to causative brain research.;178156,8;178156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 194935;654132;VULCAN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Vulnerability of soil organic carbon to climate change in permafrost and dryland ecosystems;1/07/2015;30/06/2018;;Soil organic matter provides essential ecosystem services and is one of the largest C reservoirs on Earth, holding more than three-fold as much C as does the atmosphere. Over 75% of the global soil organic C pool is stored in permafrost and dryland regions, both under high pressure due to climate change. In particular, global warming may accelerate soil organic matter decomposition in these ecosystems, which may dramatically endanger their functioning and worsen climate change by releasing significant amounts of CO2 to the atmosphere. However, the rate of this effect and to what extent it may be offset by warming-induced increases of plant-derived organic inputs remain highly uncertain. The main objective of this project is to gain a deeper insight into the vulnerability of soil organic matter to climate change in permafrost and drylands, and to explore potential implications in terms of ecosystem functioning and feedback to global warming. We will use globally unique ecosystem warming experiments in Alaska (permafrost) and central Spain (dryland), with a well-established monitoring of plant productivity, phenology, and nutrient status, soil physical, chemical, biochemical, and microbiological properties, and CO2 fluxes. We will focus on the destabilization, stabilization, and transformation processes of soil organic matter at the molecular level by using an unparalleled combination of state-of-the-art methods for soil organic matter fractionation into pools directly related to conceptual preservation mechanisms, powerful stable and radioactive isotope techniques, and advanced nuclear magnetic resonance tools. VULCAN will fill major gaps in our knowledge, will make this information widely available to scientists, policy makers, and the general public, and will provide the Fellow with the necessary knowledge, skills, networking, and experience to lead future research projects related to the feedbacks between climate change and terrestrial ecosystems in Europe.;201726;201726;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSIDAD REY JUAN CARLOS;ES;;; 195074;655235;SmartMass;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Behavioral and cognitive mechanisms promoting collective intelligence in human groups;1/09/2015;28/02/2017;;This research project will develop novel tools to investigate the interactions between individuals and the behavioral and cognitive mechanisms that promote the emergence of collective intelligence in humans, by integrating methods from biology, physics, economics and social sciences. Economics and biology, two disciplines that study the behavior of living beings, have followed distinct routes to analyze the behavior of human groups. While macroeconomic models rely on complex individual behavior and study static equilibria and steady states, biologists tend to focus on simple individual behaviors to study population heterogeneities and complex group dynamics. Simultaneously, physicists have developed a powerful set of methods and mathematical models to study the dynamics of particle systems and are very recently being combined with behavioral heuristics borrowed from cognitive science. Merging experimental and theoretical work, we will investigate the mechanisms by which the processing of information between individuals lead to collective decisions, and the specific situations where individual behaviors and choices are affected by the group. We will design and execute specific experiments to study how human groups select alternative solutions to solve specific problems, where anticipation about future actions/events will be formulated under different conditions of information. The resulting mathematical models based on the experimental data, including behavioral and cognitive processes at the individual scale, will give access to the type of information needed by the group to become more efficient in solving a given problem. These models will be analytically and numerically studied by means of classical and novel tools of statistical physics, complex networks and game theory. The present project thus aims to combine insights and methods from diverse disciplines to deliver novel hybrid models to study the emergence of collective intelligence in social human systems.;138807;138807;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITE PAUL SABATIER TOULOUSE III;FR;;; 195150;655661;DeepTrees;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Computational modelling of evolutionary dynamics in the deep sea;1/11/2015;31/10/2018;;"DEEPTREES will unite disciplines across life sciences, to use DNA barcoding to put error bars on the fossil record. A major challenge remains to unlock the data from past mass extinction events in earths history to help prepare us for the future. This is only possible by combining the cutting edge work of the University of California Museum of Paleontology and Centre for Computational Biology with the unique approach of integrating fossil and living deep-sea biodiversity in Sigwarts established research programme. The hosts will provide intensive training for Sigwart in computation modelling to investigate evolutionary dynamics during and after the ancient mass extinction events that are the only basis for understanding our current global biodiversity crisis.
The patchy nature of the fossil record in space and time means that our knowledge of past extinction dynamics is estimated, usually from counting the first and last appearance of species-groups. It has been impossible to know how much diversity is contained within each group, or how comparable they are, until now.
DEEPTREES will focus on marine invertebrates that have persisted through past mass extinction events: the survivors, found in large density in natural deep sea communities on organic substrata, using samples already secured for this project. Morphological and genetic features that separate living species will be quantified to develop a Bayesian framework to determine how many species cannot be counted because their defining features were not preserved. A novel modelling approach developed by Sigwart with input from Berkeley colleagues will integrate all these new data to calculate the hidden diversity in past extinction rates, bridging the gap between fossil and living species. DEEPTREEs new tools for quantifying diversity will revolutionise biodiversity assessments, with special relevance for the Marine Strategy Framework Directive, and may change the way we think about extinction forever.";251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE QUEEN'S UNIVERSITY OF BELFAST;UK;;; 194953;654241;PhenoMeNal;SIGNED;H2020-EU.1.4.1.3.;EINFRA-1-2014;H2020;PhenoMeNal: A comprehensive and standardised e-infrastructure for analysing medical metabolic phenotype data;1/09/2015;31/08/2018;;"In the coming decade a significant number of the 500.000.000 European (EU/EEA) citizens will have their genome determined routinely. This will be complemented with much cheaper (currently ~20 Euro per measurement) acquisition of the metabolome of biofluids (e.g. urine, saliva, blood plasma) which will link the genotype with metabolome data that captures the highly dynamic phenome and exposome of patients. Having such low cost solutions will enable, for the first time, the development of a truly personalised and evidence-based medicine founded on hard scientific measurements. The exposome includes the metabolic information resulting from all the external influences on the human organism such as age, behavioural factors like exercise and nutrition or other environmental factors.
Considering that the amount of data generated by molecular phenotyping exceeds the data volume of personal genomes by at least an order of magnitude, the collection of such information will pose dramatic demands on biomedical data management and compute capabilities in Europe. For example, a single typical National Phenome Centre, managing only around 100,000 human samples per year, can generate more than 2 Petabytes of data during this period alone. A scale-up to sizable portions of the European population over time will require data analysis services capable to work on exabyte-scale amounts of biomedical phenotyping data, for which no viable solution exists at the moment.
The PhenoMeNal project will develop and deploy an integrated, secure, permanent, on-demand service-driven, privacy-compliant and sustainable e-infrastructure for the processing, analysis and information-mining of the massive amount of medical molecular phenotyping and genotyping data that will be generated by metabolomics applications now entering research and clinic.";8018723,75;7697733,75;H2020-EINFRA-2014-2;RIA;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;"CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;Uppsala universitet;Biobanking and Biomolecular Resources Research Infrastructure - European Research Infrastructure Consortium;CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA;THE UNIVERSITY OF BIRMINGHAM;UNIVERSITEIT LEIDEN;UNIVERSITAT DE BARCELONA;LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;SWISS INSTITUTE OF BIOINFORMATICS";"IT;UK;FR;SE;AT;NL;ES;DE;CH"; 194958;654310;ODIP 2;SIGNED;H2020-EU.1.4.3.2.;INFRASUPP-6-2014;H2020;Extending the Ocean Data Interoperability Platform;1/04/2015;31/03/2018;;The Ocean Data Interoperability Platform project is promoting the development of a common global framework for marine data management by developing interoperability between existing regional e-infrastructures. Through a series of international workshops attracting relevant domain experts a number of prototype interoperability solutions will be developed which will be implemented by the regional data infrastructures to provide users with open access to good quality multidisciplinary data and associated services. Improved access to a range of marine data will facilitate re-use of the data and support researchers in addressing grand challenges such as climate change and conservation of marine resources.;1912086,25;1912086,25;H2020-INFRASUPP-2014-2;CSA;NATURAL ENVIRONMENT RESEARCH COUNCIL;UK;"ALL-RUSSIAN RESEARCH INSTITUTE OF HYDROMETEOROLOGICAL INFORMATION-WORLD DATA CENTRE;UNIVERSITE DE LIEGE;BUNDESAMT FUR SEESCHIFFFAHRT UND HYDROGRAPHIE;VLAAMS INSTITUUT VOOR DE ZEE VZW;INSTITUT ROYAL DES SCIENCES NATURELLES DE BELGIQUE;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;MARIENE INFORMATIE SERVICE MARIS BV;SOCIB - CONSORCIO PARA EL DISENO, CONSTRUCCION, EQUIPAMIENTO Y EXPLOTACION DEL SISTEMA DE OBSERVACION COSTERO DE LAS ILLES BALEARS;HELLENIC CENTRE FOR MARINE RESEARCH;52North Initiative for Geospatial Open Source Software GmbH;ALFRED-WEGENER-INSTITUT HELMHOLTZ- ZENTRUM FUER POLAR- UND MEERESFORSCHUNG;AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE;UNIVERSITAET BREMEN;CONSIGLIO NAZIONALE DELLE RICERCHE;INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER;IEEE FRANCE SECTION;ISTITUTO NAZIONALE DI OCEANOGRAFIA E DI GEOFISICA SPERIMENTALE";"RU;BE;DE;NL;ES;EL;IT;FR"; 195086;655292;MOTOR SIMULATION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Motor simulation: Evaluating the role of mirror neurons in humans through ECOG and Lesion Studies;1/07/2015;30/06/2018;;One of the most intriguing, yet controversial findings in neuroscience in the past two decades is the discovery of the mirror neuron system (MNS). These visuo-motor neurons discharge both when a monkey does a particular goal-directed action and also when it observes another individual doing a similar action. The result of this mechanism is thought to be the capacity to recognize that an individual is performing an action, to differentiate this action from others analogous to it, and to use this information in order to act appropriately. This mechanism has been proposed as the basis for social cognition, and deficits in social understanding, such as those seen in autism spectrum disorder, have been linked to deficits in the MNS. Here I propose to use 2 novel approaches to address the neurobiological and behavioral significance of the human mirror neuron system (hMNS). (a) I will use Electrocorticography (ECoG) in neurosurgical patients to assess where, when, and how neurons in the prefrontal, parietal and sensorimotor regions are involved in action recognition. (b) I will employ scalp EEG and behavioral measures in a unique cohort of patients with damage centered in the Inferior Frontal Gyrus (IFG) or the Inferior Parietal Lobule (IPL). If the IFG and IPL are the core regions of the hMNS, patients with lesions to these regions should show deficits in understanding others actions, intentions and emotions (when these are expressed by body motion). This research will further our knowledge on the neural underpinnings of social understanding, and on the consequences of deficits in these neural networks.;263385;263385;H2020-MSCA-IF-2014;MSCA-IF-GF;THE HEBREW UNIVERSITY OF JERUSALEM;IL;;; 195112;655459;PleisTechnoVar;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Technological Variability during the Late Pleistocene in Eastern Africa: lithic assemblages as indirect witnesses of past human population dynamics;1/10/2015;30/09/2017;;"PleisTechnoVar aims to better understand the increase in technological variability observed in Africa during the Late Pleistocene, between 70000 and 15000 years ago. While many research projects have focused on the origins of Homo sapiens and its spread Out of Africa into Eurasia, fewer research has concerned the material cultures of the populations who stayed in Africa and how they interacted with eachother. The first objective is to study this variability on the regional scale of Eastern Africa, between Kenya and Ethiopia. The second objective is to develop a methodological approach to understand the factors driving this variability. A larger scale of analysis will be used and Eastern Africa as well as the Nile Valley and the Levant will be considered in order to propose hypotheses concerning links between technological variability, environments and population dynamics.
This project is an in-depth study of the candidate's previous research axes in these regions.
In order to meet these objectives, lithic assemblages will be studied using the concept of chane opratoire and attribute analyses. Data collection will take place during short mobilities in museums in Eastern Africa, Israel and Europe. Spatial analyses will complete the study. These data will then be discussed in view of the known palaeoenvironmental data, as well as the results from the study of other types of material (zooarchaeology, geomorphology, etc.).
The research will be conducted at the McDonald Institute for Archaeological Research in the University of Cambridge where the candidate will receive high level training to improve her skills in the study of material culture (quantitative and qualitative data, theoretical background), as well as to develop new competences in spatial analysis (through the use of Geographic Information Systems (GIS)). The candidate will greatly benefit from the host organisation's experience in interdisciplinary research on the diversity of material cultures.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 195001;654825;ICELANDIC SCRIBES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Scribal networks in 17th-century Iceland: The patronage of Magns Jnsson Vigur;1/04/2016;31/03/2018;;"While much work has been carried out on medieval (including Nordic) manuscripts, literary patronage, and reading culture, less attention has been paid to these issues after the Middle Ages. While the introduction of print in the 15th century certainly altered literary production throughout Europe, its influence is now understood as less definitive than was once thought, and in Iceland especially, people continued to copy books by hand until the early 20th century, keeping alive medieval scribal practices long after they had ended elsewhere.

By researching the creation of new copies of popular texts and their transmission in 17th-century Iceland, I will discover how the manuscripts associated with one man at the centre of an important scribal network are linked with both the small Icelandic community in which they were produced and the wider networks of literacy and reading cultures throughout early modern Scandinavia. My project will gain insights through study of the manuscripts themselves, their scribes and patron, and also the texts they transmit. As a cross-disciplinary investigation of the society and culture of post-Reformation Iceland, my work will advance our understanding of Icelandic literature and society, and bring new perspectives to the wider fields of socio-cultural history, the history of literacy, and the history of the book.

Doing my research at UCPH, which has an unbroken tradition of work on Icelandic texts and manuscripts back to the 18th century, will allow me to gain new skills through training in electronic textual editing, and to produce a digital edition of an early modern Icelandic manuscript in its entirety, making my work widely accessible to diverse audiences, alongside more traditional methods of dissemination. As Danish is a major research language in my field, living and working in Copenhagen, with the daily immersion in Danish language and culture, will also enhance my skillset and advance my career prospects in my field.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;KOBENHAVNS UNIVERSITET;DK;;; 195288;656564;BICSA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Biophysical Changes in the Sahel: Ground and Satellite Based Evidence Across Scales and Disciplines;1/05/2015;30/04/2017;;"Human and climate induced desertification has been a major issue for livelihoods and food security in drylands. In this context, the Sahel has been subject to various controversial studies. Earth Observation (EO) studies show a positive trend in vegetation greenness over the last decades, which has been interpreted as an increase in biomass and contradicts prevailing narratives of widespread degradation. However, new scientific outcome suggests a massive loss in biodiversity, which again contradicts the beneficial effects of the greening theory. These apparent oppositions result from little investment that has been made in studying long-term ground data. Thus, the overall purpose of this project is to assess the opposing trends of biomass increase and species decline in the Sahel. By combining a range of long-term in-situ field data records (1980s-today) with EO time series and Very High Resolution (VHR) satellite imagery, an improved understanding on the role of trees, herbs and species on the greening Sahel will be achieved. Trends will be translated in ecosystem services and beneficial effects on livelihoods. Knowing the underlying biophysical mechanisms of the Sahel greening will resolve contradictions regarding the greening/desertification paradigms and thus be basis for future studies. Furthermore, the scientific understanding of linkages between ground and satellite data and their applicability across scales will be improved. New monitoring methods of biophysical variables address challenges in land management and food security. To achieve this, I will be trained in cutting edge skills (EO time series; object based mapping; field monitoring of vegetation productivity/biodiversity; socializing pixels; ecological services). My major mobility activity will be to bring together technically advanced EO studies from the European host and field campaigns from African scientists enforcing a research network to advance our understanding of the re-greening phenomenon.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195137;655598;ESATM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Embryonic stem cell origin of the adipose tissue macrophages;1/10/2015;30/09/2017;;Today insulin resistance (IR) is reaching pandemic proportions and it is predicted to emerge a leading worldwide morbidity by 2030. Immune cells, including the so-called adipose tissue macrophages (ATMs) have key roles in the development of this disease. Pharmacological intervention to shape ATM differentiation and function may be a straightforward approach to prevent or combat IR. However the stem cell origin of ATMs is still unclear, which blocks the development of such prevention or treatment strategies. Recent reports show that some specific sets of macrophages develop from embryonic hematopoietic stem cells (eHSCs) and not from the bone marrow as it was postulated before. Our preliminary studies raise the possibility that eHSCs are present in the mouse and the human adipose tissue and these stem cells replenish the ATMs in adulthood. The major scientific objectives of this project are to (a) address the critical question whether ATMs are derived from eHSCs, and (b) define whether the eHSC-derived ATMs can cause IR. These are novel and non-conventional ideas on the determination of IR and are challenging the current wisdom on ATM origin. The deliverables of this project may open a new path to alleviate or prevent IR through eHSCs.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET ULM;DE;;; 195020;654925;EUP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The implementation of the EU employment policies in Germany, Italy and Denmark;1/07/2015;30/06/2017;;"Unemployment is one of the major challenges that the world economy is facing at present. The European Union (EU) is trying to cope with this problem by promoting the flexicurity strategy (Europe 2020: COM(2010) 2020 final). This strategy aims to conciliate the flexibility requested by companies and the social and employment security needed by workers (COM(2007) 359 final). One of its main aspects concerns the relevant role recognized to active and passive labour market policies (active and passive LMPs). At the same time, the flexicurity concept is vague and ambiguous: this aspect brings difficulties in its implementation, and can have negative implications on the level of protection of unemployed people. The research project aims to analyse the legal implementation/adaptation (i./a.) of the flexicurity strategy with regard to active and passive LMPs in three member states: Germany, Italy and Denmark, that are representative of three different kinds of social security systems in EU, (Continental, Mediterranean and Nordic systems).
The legal i./a. will be analysed throughout an innovative inter/multidisciplinary approach focused on widen the labour law perspective throughout an applicative analysis (labour economics) and an analysis of the constitutional rights involved (constitutional law and political philosophy).
By highlighting different processes of legal i./a. of the active and passive LMPs in the considered member States, the research will contribute to increase the effectiveness of the EU employment policies in order to achieve adequate level of social security protection and activation possibilities for the EU citizens. Thus, the project aims to formulate Employment Policy Suggestions, which can be deduced from the empirical analysis outcomes, considering also integrative approaches and strategies to the flexicurity.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HUMBOLDT-UNIVERSITAT ZU BERLIN;DE;;; 195278;656491;BRANECOSMOLOGY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum and String Cosmology with Branes and Fluxes;1/09/2015;31/08/2017;;"This proposal promotes a research program in theoretical cosmology to be carried out by M. Schillo at the Institute of Theoretical Physics at K.U. Leuven. The aim of the research will be to address two of the pressing issues in modern cosmology: the lack of a reliable framework in which we can describe accelerating, vacuum dominated universes (such as our own), and the necessity for a theory of quantum gravity to describe the early universe. These problems have recently been impressed upon the cosmological community by the findings of the Planck satellite and the BICEP2 experiment, which provides ample motivation for the integration of high-energy physics and cosmology. Additionally, the fresh outlooks and theoretical models that this program is designed to produce will be necessary for the interpretation of findings of the next generation of ESA missions; without meaningful theories for the data to either support or falsify, the full potential of these missions cannot be realized. The innovative approach which will allow this research to contribute to the state-of-the-art in cosmology and move towards solutions to these problems is the combination of newly discovered dynamics and processes in string theory, which M. Schillo developed in her previous research, with the technologies of quantum cosmology and advanced string theory compactifications, in which the faculty of the high-energy group at K.U. Leuven are world-experts.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 195021;654936;AntWatFre;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hydration Dynamics of Antifreeze Proteins;1/11/2015;31/10/2017;;"Antifreeze proteins (AFPs) and antifreeze glycoproteins (AFGPs) enable the survival of various organisms in freezing or subfreezing habitats. Even millimolar concentrations of these proteins are sufficient to lower the freezing temperature by several degrees. To reach a similar freezing point depression using sodium chloride would require molar concentrations. Nowadays AF(G)Ps already find applications in food industry, for instance to prevent recrystallization in ice cream and have great potential in medical applications (cell & organ storage, operations at low temperature). Protein-water interactions are of general interest owing to the importance of protein hydration for protein function; AF(G)Ps form an extraordinary example of this coupling that is sufficiently strong and specific that the protein controls macroscopic thermodynamic properties of water. Despite their importance in nature and their industrial relevance, the mechanisms by which AF(G)Ps depress the freezing point are still poorly understood. Although substantial information presently exists on the static protein structures and thermodynamic properties of these systems, molecular scale information on the dynamics of the conformations of the AF(G)Ps, their hydration shells and their binding to ice, is extremely scarce. Here we propose to study the molecular mechanisms by which AF(G)Ps lower the freezing temperature with advanced nonlinear spectroscopic techniques like 2D polarization-resolved vibrational spectroscopy and surface sum-frequency generation. These techniques enable the label-free study of the structural dynamics of the AF(G)P conformations, their hydration shells and their mechanism of binding to the ice surface. They will be used to study several key elements in the functioning of AF(G)Ps.";165598,8;165598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN;NL;;; 195102;655398;ARBUATEM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Antibiotic resistant bacteria and genes, associated with urban agriculture in Low and Middle Income Countries: Ecological and medical perspectives;1/10/2015;30/09/2017;;About 20 million hectares of arable lands are irrigated with wastewaters in the world and almost nothing is known about the presence, evolution and dissemination of antibiotic resistant bacteria and antibiotic resistance genes in these fields, and their possible transmission to humans and animals via the food chain. The proposed project will address that scientific question by using analytical chemistry, flow cytometry, molecular biology, metagenomic approaches, and computational biology, in order to characterise antibiotic resistant bacterial community structures and antibiotic resistance genes in untreated wastewaters and the corresponding irrigated agricultural sites compared to control sites in low and middle income countries, as well as the influence of abiotic factors. The new scientific data arising from this project will help to determine the factors that drive resistance and can be minimized by developing strategies to prevent further spread of antibiotic resistant bacteria and antibiotic resistance genes worldwide. The fellow, with a strong background in Microbial ecology and Biochemistry, will conduct this project under the supervision of Prof Piddock, a medical microbiologist and expert in antibiotic resistance, at the University of Birmingham.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF BIRMINGHAM;UK;;; 195084;655279;ResolvedJetsHIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Probing the Strongly-Coupled Quark-Gluon Plasma with Jets;1/11/2015;31/10/2017;;"'Nuclear matter converts into a quark-gluon plasma (QGP) in the course of energetic collisions of heavy nuclei.
This transformation allows to study the strong interaction, as described by Quantum Chromo-Dynamics (QCD), in dynamical conditions similar to those prevalent in the early Universe. The QGP behaves as a strongly interacting fluid, in consequence posing a challenge to established frameworks and calling for novel theoretical developments. A precise class of probes are the so-called 'hard' probes and among them the formation of jets, sprays of hadrons created in the fragmentation process of a highly energetic quarks and gluons, are of special interest. The proposed project aims at advancing jet observables as theoretically well-controlled probes of the QGP. One of the key goals is to understand and numerically simulate the fragmentation process of energetic quarks and gluons into jets in heavy-ion collisions. In a second line of action we would like to address the nature of the QGP in realistic conditions by studying the active degrees of freedom released in course of the collision, and investigate their effect on jet observables. In accomplishing the proposed objectives, we will establish a clearer interpretation of experimental data from present and future particle colliders as well as bridging the insight from various theoretical attempts at describing the strong nuclear force.'";175419,6;175419,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;;; 194920;654006;SalHyd5;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Characterization of Salmonella enterica hydrogenase-5 biosynthesis for developing novel anti-infective compounds;1/09/2015;31/08/2017;;Recently, the discovery of new antibiotics has slowed, while the incidences of infections caused by bacteria that have become resistant to commonly used antibiotics are rising. There is therefore a growing clinical need for innovative approaches to developing novel anti-infective compounds. Hydrogen is an important energy substrate for a number of pathogenic bacteria and H2 oxidation is essential for the virulence of Salmonella enterica serovar Typhimurium. S. enterica expresses three different H2-uptake [NiFe]-hydrogenases and one of these (termed hydrogenase-5) belongs to a novel class of O2-tolerant hydrogenases that is synthesized aerobically and oxidizes H2 in the presence of O2. The Hyd-5 gene cluster encodes two accessory proteins, HydH and HydG, that are absent in anaerobic systems and are conserved in those systems in which hydrogenases are synthesized in the presence of oxygen. In other systems, HydH homologs have been proposed as scaffolding proteins that bind the immature [NiFe] cofactor prior its transfer to the large subunit of the enzyme. HydG-like proteins are hypothesised to assemble or stabilize the Fe-S clusters of small subunit during biosyntheis. This proposal aims to study the functional role of accessory proteins HydH and HydG in the biosynthesis of Hyd-5 and to design novel small molecule compounds that potentially inhibit hydrogenase activity and assembly. Understanding the mechanisms involved in the biosynthesis of Hyd-5 will allow the development of hydrogenase inhibitors and, as consequence, anti-infectives of virulence of Salmonella and other bacterial pathogens. This project addresses a key biomedical challenge and establishes [NiFe] hydrogenases as novel and credible drug targets.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of Dundee;UK;;; 195059;655159;MicroCity;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Microbes in the city: a metagenomic trait-based analysis of microbial metacommunity structure along urbanization gradients;1/05/2015;30/04/2017;;"Human induced environmental gradients have a strong effect on biodiversity and ecosystem functioning. Despite the valuable ecosystem services (such as biogeochemical cycling and xenobiotic degradation) provided by microbial communities, environmental conservation policies usually neglect microbial diversity. This can be in part attributed to our poor understanding of microbial community responses to anthropogenic influences in natural landscapes. Urban ecosystems are key examples of environments that are strongly impacted by anthropogenic activity. In addition to our need to understand how microbial communities respond to urbanization, urbanization gradients are also excellent model systems to study how the taxonomic and functional diversity and composition of microbial communities respond to anthropogenic stress in general.
In the here proposed project, we will study microbial communities in freshwater ponds located across well characterized urbanization gradients in Belgium. We will apply metagenomics in a molecular trait based approach in an effort to determine the influence of human induced environmental gradients on the biogeochemical cycling and xenobiotic degradation pathways in microbial communities. Also, we will analyse the role of the mobilome - mobile genetic elements such as plasmids and transposons - as a source of rapid evolution in microbial communities under anthropogenic stress. We will take a metacommunity approach in order to quantify the relative importance of local (environmental) and regional (spatial) processes in shaping bacterial communities across the studied gradients.
Our proposed study is unique as it combines the nascent theory of evolving metacommunities with a high throughput molecular approach, metagenomics, to better understand the impact of urbanization on microbial community structure and function.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 195135;655527;Leucophyl;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Total Synthesis of Leucophyllidine;15/12/2015;14/12/2017;;In the frame of this research program, carried out at the Institute of Molecular Sciences (ISM) at the University of Bordeaux (UB), we propose a strategy directed towards the first total synthesis of leucophyllidine, a cytotoxic alkaloid recently isolated from L. griffithii. From the retrosynthetic analysis of the target, two fragments where identified that will be prepared then connected in the last stage of the synthesis, following a biomimetic approach. The North-fragment will be synthesized relying on a coupling between a key-aldehyde moiety and tryptamine through a Pictet-Spengler reaction/lactamization cascade. The South-fragment will be elaborated using a Friedlnder-type condensation between a piperidinone, and an ortho-aminobenzonitrile. The key-aldehyde and the piperidinone will be elaborated using a unified strategy, including a novel stereoselective free-radical carbo-oximation process, which will install quaternary centers present in North and South fragments. Incorporation of the vinyl motif on the naphthyridine ring, through a Suzuki coupling, should complete the synthesis of the south-fragment. Both fragments will finally be connected, following a biomimetic Mannich-type strategy, which should provide sufficient quantities of this potent anticancer agent and analogues for future biological screening. Key objectives of this research program are the development of an access to new plant anticancer drugs for potential clinical use and the training of future leading experts in the field of natural productderived drugs discovery, a domain in which Europe must remain competitive in the 21st century as cancer-related diseases are rapidly increasing with populations life expectancy.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universit de Bordeaux;FR;;; 194938;654147;Invisibilia;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Tracing the Invisible. Old Norse and Latin in medieval manuscripts.;1/09/2016;31/08/2018;;In the project Tracing the Invisible. Old Norse and Latin in Medieval Manuscripts (INVISIBILIA), I propose to investigate bilingualism in medieval Northern Europe by focussing on the most popular media of the time: manuscripts. I will trace their Latin components, which have mostly been neglected in research until the present day, and make them accessible to the scientific community digitally, thus providing essential texts and finding aids for the Latin sections. I will analyse the interaction of the Latin with the Old Norse texts. By relating them to the production, dissemination and use of manuscripts by people from different social backgrounds, I will give a deep insight into the European literacy of medieval Icelanders and Norwegians in the time span ca. 1100 ca. 1500. INVISIBILIA will focus on the manuscripts held in the Arnamagnaean Collections in Copenhagen and Reykjavik, which represent approx. 90 % of the total number of Old Norse codices. Any exemplar containing both Old Norse and Latin as clearly distinct entities will contribute to the corpus of the study, about 400 manuscripts in total. I will approach this corpus according to three major research objectives, namely a full catalogue of the Latin entities, a comprehensive multi-level edition, and a comparative study. The results of the three research objectives will be integrated in an enhanced publication, realising the latest developments in Digital Humanities. This open access, on-line website will exchange data with existing scientific databases and make it possible for other scholars to collaborate actively. By spanning the borders between Traditional and Material Philology, Cataloguing and Editing, and Traditional and Digital Humanities, INVISIBILIA reaches out to scholars of medieval Scandinavia and Medieval Latin alike. The research results will be directly comparable to other pre-modern bilingual literary systems and challenge the isolationism still found in Old Norse-Icelandic scholarship.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195071;655226;BIHC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;BIHC- Bio-inspired models of human crowds;1/07/2015;31/12/2017;;With current consumer-grade personal computers, it is possible to display 3d virtual scenes with thousands of animated individual entities at interactive frame rates. Crowd simulations are, however, too often limited to characters lacking individuality and wandering in an environment without a specific goal. This situation is particularly problematic in the field of cultural heritage in real-time simulations of the past where the realism of individual behavior is critical. This proposal, through a collaboration across the computer science and the archaeology fields, seeks to address this problem. It aims at exploring bio-mimicking techniques in the development of a generative model for heterogeneity and spontaneity in behavioral animation of crowds. More specifically, the goals can be defined as (i) the development of a bio-inspired model of agency for virtual humans (which upgrades a previous prototype, part of my earlier research), (ii) the development of an authoring tool to interact with the parameters of that model and develop context-specific behaviors/animations, and finally (iii) the development of a proof-of-concept - the simulation of a historical environment, with the assistance of non-programmers using the authoring tool developed earlier.;220882,5;220882,5;H2020-MSCA-IF-2014;MSCA-IF-GF;FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP;PT;;; 195273;656467;SUPRONICS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Novel graphene-supramolecular elastomer hybrids for self-healing stretchable electronics;1/12/2015;30/11/2017;;Stretchable electronics are highly attractive in various applications including wearable medical devices. However, most of the existing conducting materials used in electronics lack either high stretchability or high conductivity, largely limiting their applications. Inspired by the self-healing ability of skins, this project aims to develop next-generation conducting materials with combined high stretchability, high conductivity and intrinsic self-healing ability, based on novel graphene-supramolecular elastomer hybrids. The graphene-elastomer hybrids will be synthesised and investigated in depth for formulating the materials and obtaining a deep understanding of their mechanical, electrical and self-healing behaviour. Their application as stretchable electronics will be demonstrated by inkjet printing of the optimal material to form printed electrical circuits for wearable medical devices. These novel nanomaterials will significantly enhance the performance and lifetime of stretchable electronics as well as the design flexibility of future devices, whilst also facilitating the low-cost fabrication of electrical circuits through printing technologies.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF SHEFFIELD;UK;;; 195097;655367;TUNEMODE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;TUNABLE MODE RANDOM FIBER LASER FOR MODE DIVISION MULTIPLEXING LASER SOURCE;30/11/2015;29/11/2017;;The evolution of the bandwidth demand in optical fiber communication system in the Europe region keeps increasing year after year. As for now, most of these demands are supported by the WDM system of optical communication network. It is forecasted that this increasing bandwidth demand could not be supported any more data traffics in the future due to the consumption growth of new applications. In this regards, a new system for solving this issue is becoming all the necessary. An alternative which is forecasted to be able to fulfill this demand is Mode Division Multiplexing (MDM). MDM basically is based on a concept developed for increasing the optical data transmission capacity within the optical fiber itself. Thus, this project will be carried out to investigate the mode tuning of random fiber laser for the application in MDM system. The main objective of this project is to generate a laser with various modes which can be tuned by using few mode fiber and will be using random fiber laser. The purpose of using random fiber laser is because the conventional rare earth based fiber laser such as Erbium and Ytterbium are not optimized for lasing at higher order mode than the fundamental mode LP01. Investigation on mode tunability will be carried out using micro fiber technology and also fiber Bragg grating technology whereby the combination of these two technologies will be functioning as the tunable and filtering element. Also, in this project, new ideas and concepts will be developed whereby the generation of a laser with various modes will probably generate new concepts and findings, not only for MDM system, but also for the device to support this application in the future. In this regards, this research is very significant, in conjunction with the growth of the bandwidth demand in the Europe region as well as in the world.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 194986;654721;GEOGRAL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Geometry of Grassmannian Lagrangian manifolds and their submanifolds, with applications to nonlinear partial differential equations of physical interest;1/09/2015;31/08/2017;;"The aim of GEOGRAL is to strengthen the bonds of the geometric theory of nonlinear PDEs (and, in particular, integrable systems and equations of Monge-Ampre type) with the geometry of Lagrangian Grassmannians and their submanifolds. In spite of the evident parallelism between these two disciplines, attempts have been rare, yet sophisticated, to cast a bridge between them, and the Applicant himself already gave his own contribution in this direction: he clarified the structure of the space of non-maximal integral elements of the contact planes in jet spaces and studied 3rd order Monge-Ampre equations (which turn out to be of key relevance in topological field theories) through the so-called meta-symplectic structure on the 1st prolongation of a contact manifold.
GEOGRAL has a wide applicative scope, as its theoretical results can be tested on equations and variational problems of key importance for Natural Sciences, Technology and Economy. Tailored to the Applicant's scientific profile and designed in continuity with his previous and current research activities, GEOGRAL consists of four research lines:
[MOV] Regard Lagrangian Grassmannians as homogeneous spaces and and use Cartan's method of moving frame to classify their submanifolds, as in D. The's work, and characterise the corresponding invariant equations, in continuity with D. Alekseevsky's work.
[HYD] Continue the study of certain rational normal curve bundles on Lagrangian Grassmannians, and their bisecant varieties, which are associated with integrable systems of hydrodynamic type, discovered by E. Ferapontov.
[HMA] Geometric study of multi-dimensional and higher-order Monge-Ampre equations, initiated by G. Manno and the Applicant.
[FBV] Study some examples of Cauchy problems and variational problems with free boundary values by exploiting the geometric structures on the spaces of isotropic flags and non-maximal isotropic elements of a meta-symplectic space, in continuity with the Applicant's own work.";146462,4;146462,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTYTUT MATEMATYCZNY POLSKIEJ AKADEMII NAUK;PL;;; 195005;654853;Egg-Juvenate;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deciphering the roles of chromatin modifiers in germline aging;1/05/2015;30/04/2017;;Faithful transfer of genetic material is critical for the success of all cell divisions. Yet, as the organism ages this process becomes more error-prone, leading to aneuploidic daughter cells due to mis-segregation of chromosomes. This can lead to cancer in mitotic cells, and in the female germline it leads to reduced fertility and exponential increase in miscarriages and birth defects already at the third decade of life. In humans, all the oocytes begin their development in-utero but arrest for decades in the middle of this process leading to the rapid increase in meiotic divisions failure. The oocytes arrest while undergoing dramatic structural changes, termed chromosome remodelling. Very little is known about what drives this critical phase in germline development, yet it is assumed to involve chromatin modifiers and DNA binding complexes. I propose to identify chromatin-modifying complexes that act in chromosome remodelling and find their mechanism of operation. This will be achieved by utilizing my recently developed technologies and RNAi screen results, which gives me unique tools and approaches to study this complex process. This research will open the window into the connection between chromatin modifiers that facilitate chromosome restructuring and germline aging. The research is aimed to find the major players in this processes and their mode of operation. In an age where maternal age is rising in the western world, translational implementation of this research would have a dramatic impact on our scientific understanding of fertility.;182509,2;182509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE HEBREW UNIVERSITY OF JERUSALEM;IL;;; 195069;655209;ILDS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Integrability and Linearization of Dynamical Systems;1/07/2016;30/06/2018;;"The proposed research includes the following two main directions:
(1) Using methods and tools of algebraic geometry and computational algebra, we study the integrability of the nonlinear dynamical systems. We focus on finding the varieties of integrability of dynamical systems with the emphasize on the higher dimensional systems. Our approaches are based on combining symbolic computations with methods of the theory of integrability of dynamical systems. We then study bifurcations of limit cycles and critical periods arising after perturbations of higher dimensional integrable systems of differential equation. Furthermore, we intend to study the problem of isochronicity (which is equivalent to the problem of linearization).
(2) We propose to study the global topological linearization, linearization of integral manifold, smooth linearization with the emphasis on the study of the linearization of non-autonomous systems when the nonlinear term is unbounded or linear system does not possess exponential dichotomy (in critical state). Up to now there are few results concerning the linearization";157287,6;157287,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERZA V MARIBORU, CENTER ZA UPORABNO MATEMATIKO IN TEORETICNO FIZIKO P.O. ZAVOD;SI;;; 195006;654860;TRANSLATIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Translating from Latin: Contacts, Transfer, and Rewriting of Historiographical Texts in Medieval Iceland;1/09/2015;31/08/2017;;"Translated texts play an important role in the beginning of literacy in the vernaculars in the European Middle Ages. The process towards literacy is initiated by the arrival and then propagation of Christianity. Translation, however, did not only serve as a means to promote the new religion, it kept being an important tool for the import of cultural goods.
The project will concentrate on historiographical texts translated from Latin into Old Norse. While it does not seem far fetched to assume that those translations might have had a function as literary models, one might also ask about the socio-cultural motivations and functions of those texts: Were the Icelanders only interested in importing the common matters which were in fashion everywhere in Europe? Or did they also import new concepts that came with the texts? And if so, how were they translated and transformed for the audience? Is it possible that some people even used certain texts to promote their political agenda? Who were those people? Where and who were their contacts?
While the final goal could be called a sociology of translation on the novel theoretical background of Translation Studies, the methods are philological under the paradigms of Material and New Philology. With a background in Medieval Latin and Classics (MA) as well as Scandinavian Studies (PhD) I am ideally qualified to conduct research on texts translated from Latin into Old Norse. The European dimension of the EF makes it the ideal format for this project, since it would make it possible to work at the best institution for research in the field of Old Norsethe Arnamagnan Institute in Copenhagen. The training in manuscript studies, digital humanities, and lexicography that will be provided in this first-rank institution in the field of Old Norse and the innovative monograph that will be the major outcome of this project will advance my career significantly and enhance my international employability in academia.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195087;655283;3DWISE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;3D Full Waveform Inversion on seismic data at the East Pacific Rise;1/09/2015;31/08/2017;;"The mid-ocean ridge system is the longest volcanic mountain chain that wraps around the Globe along which two plates have been separating and oceanic crust has been forming by highly active magmatic processes operating within and at the base of thus formed crust. It is believed that there is a strong link between these magmatic processes known at large spatial scales (1-100 km) and relatively localized (0.001-1 km) tectonic/ volcanic/hydrothermal/biological processes, and their expression onto the seafloor. However, the characteristics of the link are largely unknown. The origin of the most of the unknowns is embedded in poorly defined properties of the upper crust (its structure, P and S wave velocities, porosity, density, anisotropy, etc.), where the link is hosted and its activity is taking place.
To map these properties at an unprecedented resolution scale and unveil the existing link, we propose to apply an advanced three-dimensional (3D) full waveform inversion (FWI) technique, which has been recently developed in partnership with industry, to a unique 3D seismic reflection data acquired at the East Pacific Rise. The proposed work will not only result in detailed spatial characterization of the upper crust, but also lay foundation for the 3D FWI as a standard tool for 3D geophysical subsurface exploration of, but not limited to, global tectonics.
The study area, the East Pacific Rise at 950N, is a portion of the mid-ocean ridge system characterized by prolific hydrothermal activity, two documented volcanic eruptions and substantial multidisciplinary time-series measurements (unique on the Earth), offering interdisciplinary approach to solve one of the most fundamental problems in Earth sciences. These results will also enable us to tackle some of the long-standing questions on patterns of hydrothermal flow, signature of fine-scale tectono-magmatic segmentation through the upper crust and volume estimates of the erupted lava emplaced on the seafloor.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT DE PHYSIQUE DU GLOBE DE PARIS;FR;;; 195263;656397;THISTLE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Transformation and the management of HIStorical foresT. Landscapes of the Eugaean Hill (Padua, Italy). Fresh perspectives through spatial analyses and dendro-anthracology;1/04/2016;31/03/2018;;"To better anticipate global changes (environmental, climate and social changes), research over the past twenty years has focused on understanding and measuring the interactions between societies and their environment. Knowledge of past environments and their evolution in relation to society can help contribute to better manage, protect and anticipate present and future environments.
This project adds to this dynamic research with a focus on forests. Forested landscapes represent the ecological inheritance of centuries of forest management to supply, among other products, the fuel necessary for human activities. Thus, to meet their demands for firewood past societies gradually modified and transformed the landscapes they inhabited. We focus here on the evolution of historical forests in the Euganean Hills (Colli Euganei, Padua-Italy) through wood charcoal production. Charcoal production is extremely polymorphic and fully understanding it requires the use of different approaches and disciplines (including history, ethnography, archaeology, geography, archaeobotany etc.) The aim of this project is to develop an integrated approach combining all disciplines to reconstruct forest landscapes on the Euganean Hills at different temporal and spatial scales.
The choice of the Euganean Hills has been guided by its interesting biodiversity, by the numerous diachronic archaeological surveys previously undertaken, by the wealth of written and cartographic documentation concerning the uncultivated lands and also by the willingness of local actors to promote their region thanks to the richness of the landscape and its history. The project THISTLE aims to reconstitue the history of cultural landscapes, and more precisely of forest landscape of the Euganean Hills (Colli Euganei, Padua-Italie) with a pluridisciplinary approch in order to protect and promote them at different geographical scales (from local to global).";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI PADOVA;IT;;; 195044;655100;AdaptClim;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genomic and epigenomic signatures of climate-mediated selection in cattle;1/05/2015;30/04/2017;;Official assessments of climate change impacts in Europe predict substantial economic losses due to the progressive upward trend in average temperatures over the next century, and the decrease in annual accumulated rainfall. Global warming will lead to a decreased forage production and quality, and an increased disease risk, which will significantly change conditions for livestock production. Therefore, increasing climate resilience and enhancing sustainable production for animals in harsh environments are important goals for the livestock industry. Fortunately, a natural experiment already exists where a rapid adaptation to extreme climatic conditions was imposed on a limited number of livestock, Columbus arrival in the Americas, which therefore provides a model system to study adaptive selection. Given the accumulating evidence that epigenetic processes may increase the evolutionary potential of organisms to respond to stress and other challenges, the aim of this project is to compare the genomes and methylomes of two tropical Creole bovine breeds, their main Spanish ancestors, and one taurine breed from Africa, to understand rapid adaptation to extreme climatic conditions and identifying biomarkers of resilience. The anticipated outcomes from this project will help in designing management systems to improve productivity, thermal and stress tolerance, and disease resistance in cattle.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CARDIFF UNIVERSITY;UK;;; 194924;654034;SCIMOD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Scientific Models, Fiction and Imagination;1/10/2015;30/09/2017;;The project aims to systematically explore a novel approach to model-based reasoning drawing on the relationship between the debate on the nature of scientific models from philosophy of science and the debate on the nature of fiction from aesthetics. Many contemporary philosophers of science argue that learning with models involves a special cognitive function that they call surrogative reasoning or model-based reasoning. Understanding model-based reasoning can be divided into two subprojects: what model-systems are (SP1) and how knowledge about the model is converted/interpreted into knowledge about the target (SP2). Work within (SP1) will be driven by the hypothesis that scientific models are akin to the fictions of literature and the arts. Work within (SP2) will be driven by the hypothesis that interpretation is mediated by a representational relation converting a fact about the model system into a claim about the target system. The project relies on the normative and descriptive methodology of analytical naturalised philosophy of science, which focuses on examples and case studies. The project will benefit from the combination of Friggs expertise in philosophy of science and modelling and of Salis original specialization in the areas of aesthetics and the philosophy of fiction. Furthermore, we will collaborate with the experts from the CPNSS Philosophy of Physics project at LSE, with the decision theorists and social choice experts in the LSEs Choice Group and with the CATS (Centre for the Analysis of Time Series) group on climate models based at LSE. This study will lead to new insights into the nature of scientific modelling and model-based reasoning and it will open new lines of research by injecting a new and fresh perspective from aesthetics into philosophy of science.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;UK;;; 195122;655508;COMMANDEER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;COMMANDEER: Disrupting microbial resistance using rationally designed signalling molecules;1/07/2015;30/06/2017;;"Cystic Fibrosis (CF) is an inherited disease which affects 100,000 people worldwide and is prevalent in European populations. CF causes the body to produce an abnormally sticky mucus in the lungs making patients susceptible to serious bacterial infection. By age 8, 50% of CF patients are infected with Pseudomonas aeruginosa increasing to 80% by 20 years of age. Eventually, the infecting strains of bacteria become resistant to antibiotics and remain a chronic inhabitant of the lungs of CF patients until they succumb to respiratory failure, usually by the young age of 30-35. Approximately 60% of CF patients are co-infected with Burkholderia cenocepacia that settle into the thick mucus of the airways. These bacteria have evolved a special type of defence mechanism to antibiotics whereby they excrete a chemical messenger on treatment. This chemical messenger -Diffusible Signal Factor or DSF - activates bacterial biofilm formation. Previous work has shown that DSF effectively behaves as an emergency flare to other bacteria, which produce a biofilm in response. This biofilm acts as a shield which protects the bacteria from the effects of antibiotics.

As a key fits in a lock, DSF fits into bacterial receptors and switches on biofilm formation. In this COMMANDEER project, we will synthesise molecules which mimic DSF and fit into the same biological receptors. However, due to subtle changes in their design, our molecules will switch off biofilm formation. Using this novel strategy of effectively commandeering the bacterias signalling system, we will disable biofilm formation, making the bacteria susceptible to antibiotics once again. We will adopt a multidisciplinary and collaborative approach combining the talents of chemists in Ireland and microbiologists in the UK. This project, therefore, represents a new and exciting route of circumventing bacterial resistance, offering significantly improved quality of life for CF patients and increased life expectancies.";187866;187866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;;; 195120;655497;NNL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;An exploration into the feasibility of simultaneously achieving No Net Loss of biodiversity and ecosystem services, in an uncertain and changing world;1/09/2015;31/08/2017;;"We are evidently currently witnessing an ongoing loss of global biodiversity, caused largely by anthropogenic activity, and thought to be resulting in a loss of associated ecosystem services. However, the economic development that often leads to net loss of ecosystem services also provides benefits to humanity. An optimal balance between development and biodiversity conservation must be found.

A promising new policy principle is No Net Loss (NNL) giving rise to mechanisms in which biodiversity losses from development are measured, and conservation interventions implemented that fully compensate for those losses, resulting in no net loss of biodiversity alongside development. However, it has been suggested that biodiversity and ecosystem services can not always both be maximised. Further, NNL is not a trivial objective when ecological dynamics (e.g. climate change) and social dynamics (e.g. institutional change) are taken into account. It is crucial that we establish whether there are general principles that can be applied to achieving NNL across different ecosystem types, and if not, what are the most significant peculiarities to each system.

We propose to begin by creating for the first time a database of existing NNL interventions, as well as developing frames of reference for NNL interventions in a set of case study ecosystems. Systems are likely to include both European and other countries.

Building on this empirical basis, we will develop bespoke simulation models (using a novel implementation of the Management Strategy Evaluation framework) for each ecosystem, and explore implementation of different NNL mechanisms. We will consider feedback between social and ecological system components, drivers of change such as climate change, and sources of uncertainty.

The outputs will allow us to determine whether there are general principles concerning how and when NNL of both biodiversity and ecosystem services can be achieved in a given dynamic system.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195056;655143;EMOTIONS FIRST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;EMOTIONS FIRST. Feeling reason: the role of emotions in reasoning;1/01/2016;31/12/2017;;"Emotions First: Neuroscientists have recently discovered the primacy of feelings and emotions over reasoning, in our mental life. On the basis of these results, cognitive scientists are developing a semantics of conceptual classification, grounded on feelings and emotions towards the world. My work for the Marie Curie aims to show that the ancient Greek philosophers developed theories of action, where the battle between our desires and feelings towards the world grounded the pattern of rationality that emerged from this battle. On my reading of ancient philosophy primarily Plato, Aristotle and the Stoics the process of reasoning arises from a calculus of feelings and emotions (culminating in love), which aim towards the organisms good. Socrates held that every human has an innate desire for his or her own good; the human organism struggles to find the good, guided by the desires of the soul. Plato and Aristotle saw the human soul as a locus of desires and motivations, whose contest constitutes deliberation for the good. For both philosophers, the souls competing motivations and feelings towards the world result in pleasure, if the competition outcome is successful, and in pain, if not. The successful competition is reasoning, the unsuccessful, miscalculation. I aim to investigate the hypothesis that the emotional quest for the good of the organism is constitutive of rationality in an international research-hotbed of emotions in reasoning, at the Philosophy Centre of Edinburgh University, where philosophy meets cognitive science on emotive lateral thinking and on the extended knowledge hypothesis. The training I can receive at this Center will empower me to present in the best theoretical framework the ancients intuition that the calculus of feelings can shed light into the origins of rationality. This is my ambition for the Marie Curie Fellowship.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 194905;653874;EDUCEN;SIGNED;H2020-EU.3.7.;DRS-21-2014;H2020;European Disasters in Urban centres: a Culture Expert Network (3C Cities, Cultures, Catastrophes);1/05/2015;30/04/2017;;EDUCEN is a coordination and support action that will work on the complex interplay between culture(s) and disaster risk reduction, above all in the context of cities, to allow in particular formal and informal emergency responders, risk managers, the military, urban planners and planners at regional and national level to be better equipped to deal with elements of culture, and as a result to ensure highly competent disaster responses and increasing community resilience. It is our contention that disaster risk reduction policies and practices are intrinsically cultural as they emerge from and are therefore largely shaped by the interplay of cultures prevalent at both the community, organisational and institutional level. Therefore any endeavour aimed at improving disaster risk reduction efforts should be founded on a comprehensive understanding and appreciation of this interplay and more importantly of the influential role of culture on the way people prepare for, experience, respond, and recover from disasters. EDUCEN will achieve its objectives this by firstly allowing knowledge and understanding of culture(s) in light of disaster risk reduction to become accessible to relevant stakeholders and secondly by encouraging, enabling and sustaining multi-stakeholder dialogue through which academics, practitioners and communities can actively engage and share knowledge, expertise and experiences which will enable all to strengthen their capabilities and impact, but most importantly will allow for both formal and informal risk managers and planners and spatial planners emergency responders in cities to be better informed and guided. The final product will be a multi-level, multi-media handbook, including visuals, maps, written narratives, and videos to support disaster risk reduction professionals to better appraise relevant cultural aspects in their own community of practice as well as in the environment where they intervene.;1741905;1644671,25;H2020-DRS-2014;CSA;WAGENINGEN UNIVERSITY;NL;"CONFEDERACION HIDROGRAFICA DEL SEGURA;ANAPTYKSIAKH BOLOY ANAPTYKSIAKH ANONYMH ETAIRIA (AE);STOWARZYSZENIE CENTRUM ROZWIAZAN SYSTEMOWYCH;MINISTRY OF DEFENSE;CONSIGLIO NAZIONALE DELLE RICERCHE;POLITECNICO DI MILANO;I-CATALIST SL;ARAMA KURTARMA DERNEGI (AKUT);STIFTELSEN THE STOCKHOLM ENVIRONMENT INSTITUTE";"ES;EL;PL;NL;IT;TR;SE"; 194944;654168;AIDA-2020;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;Advanced European Infrastructures for Detectors at Accelerators;1/05/2015;30/04/2019;;"Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology are required to ensure the success of these endeavours.

The AIDA-2020 project brings together the leading European infrastructures in detector development and a number of academic institutes, thus assembling the necessary expertise for the ambitious programme of work. In total, 19 countries and CERN are involved in this programme, which follows closely the priorities of the European Strategy for Particle Physics.

AIDA-2020 aims to advance detector technologies beyond current limits by offering well-equipped test beam and irradiation facilities for testing detector systems under its Transnational Access programme. Common software tools, micro-electronics and data acquisition systems are also provided. This shared high-quality infrastructure will ensure optimal use and coherent development, thus increasing knowledge exchange between European groups and maximising scientific progress. The project also exploits the innovation potential of detector research by engaging with European industry for large-scale production of detector systems and by developing applications outside of particle physics, e.g. for medical imaging.

AIDA-2020 will lead to enhanced coordination within the European detector community, leveraging EU and national resources. The project will explore novel detector technologies and will provide the ERA with world-class infrastructure for detector development, benefiting thousands of researchers participating in future particle physics projects, and contributing to maintaining Europe's leadership of the field.";12909986,73;10000000;H2020-INFRAIA-2014-2015;RIA;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;"Johannes Gutenberg Universitaet Mainz;INSTITUTE OF NUCLEAR RESEARCH AND NUCLEAR ENERGY - BULGARIAN ACADEMY OF SCIENCES;INSTITUTO DE FISICA DE ALTAS ENERGIAS;AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;VILNIAUS UNIVERSITETAS;THE UNIVERSITY OF MANCHESTER;LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS;ISTITUTO NAZIONALE DI FISICA NUCLEARE;INSTITUT JOZEF STEFAN;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT;UNIVERSITY OF GLASGOW;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;FYZIKALNI USTAV AV CR V.V.I;STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;UNIVERSITE CATHOLIQUE DE LOUVAIN;THE UNIVERSITY OF LIVERPOOL;THE UNIVERSITY OF BIRMINGHAM;INSTITUTO TECNOLOGICO DE ARAGON;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;KARLSRUHER INSTITUT FUER TECHNOLOGIE;RUDER BOSKOVIC INSTITUTE;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;TEL AVIV UNIVERSITY;UNIVERSITY OF BRISTOL;UNIVERSITE DE GENEVE;LUNDS UNIVERSITET;UNIVERSITY COLLEGE LONDON;MAGYAR TUDOMANYOS AKADEMIA WIGNER FIZIKAI KUTATOKOZPONT;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN;FONDAZIONE BRUNO KESSLER;UNIVERSITETET I BERGEN";"DE;BG;ES;PL;UK;LT;PT;IT;SI;FR;CZ;BE;HR;CH;IL;SE;HU;AT;NO"; 195041;655043;FeSensor;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Finding the iron sensing protein in crop plants;1/05/2015;30/04/2017;;Iron (Fe) is needed for all living organisms but in high concentrations within the cell it is toxic, therefore balancing the physiological level of iron is essential. Although the Fe sensing mechanism has been described for a wide variety of living forms, from bacteria to mammals, no clear information about how plants sense Fe is available. Whether or not Fe is sensed in roots or in shoots or in both, the chemical form of the Fe or the identity of the sensing protein, remains unknown. In yeast and mammals, Fe is sensed via Fe-S proteins, but in plants the Fe sensing mechanism has been shown to be independent from Fe-S cluster assembly in the mitochondria or cytosol. Using comparative transcriptomics in two model plant species I have identified a small family of genes (IRS1, IRS2 and BTS) that are good candidates for the plant Fe sensors. I would like to investigate if their putative Fe binding motifs, haemerythrin and rubredoxin, are functional in an Fe-sensing capacity. Moreover, I will investigate if the proteins have ubiquitination activity as predicted, and tissue-specific expression compatible with a double sensing mechanism in roots and leaves. Other possibilities for the Fe-sensing mechanism will be explored by using mutants defective in Fe-S assembly in the plastids, and unknown candidates will be uncovered with an unbiased mutant screening. Perturbing the Fe sensing mechanism in a tissue-specific manner would be a smart way of increasing the Fe content without causing toxicity symptoms in the rest of the plant.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF EAST ANGLIA;UK;;; 194971;654490;GREAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Deformations of fundamental Groups of REpresentATions;1/01/2016;31/12/2016;;"The aim of this project is to consider X a smooth projective algebraic curve and a representation ? of 1(X) into a semisimple Lie group G, and study deformations of ? when X deforms into a singular curve. This question will open a brand new direction in the theory of representations of fundamental groups and G-Higgs bundles. The main tool to approach the problem will be non- abelian Hodge theory to transform this topological question into the geometric one. Then we use recent new developments in the classification of representations together with new algebraic objects which recently appear in non-abelian Hodge theory to study this question. It will take us to the study the deformations of G-Higgs bundles together with deformations of harmonic bundles over X when X is a curve and varies.
This project will allow the researcher to broaden her area of expertise as well as to develop new directions in her research lines. She will complement her knowledge in differential geometry in one of the most prestigious Universities and under the guidance of one of the worldwide leaders in this field.";91727,4;91727,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194990;654732;NICHE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Navigating and Innovating in Complex Healthcare Ecosystems;15/08/2015;14/11/2017;;"Navigating and Innovating Connected Health Ecosystems (NICHE)
How can technology firms beneficially influence healthcare provision? Technology is vital for future well-being given economic and demographic strain on healthcare systems but market innovation has proven difficult to implement.
Conventional marketing is based on linear diffusion models created for consumer or investment goods markets. In healthcare however, innovating firms face diverse stakeholders: healthcare practitioners, buyers, consumers, regulators, politicians, the media and the public at large. Innovation in such ecosystems requires interactive and iterative processes of R&D, market sensing, networking, coalition building, and deep understanding of healthcare and regulatory practices. This project will assist healthtech companies to navigate, influence and gain traction for their innovations in complex healthcare ecosystems by designing and testing a healthcare market engagement roadmap:
1) a user-centric assessment tool to identify stakeholders, stakeholder practices and incumbent technologies with which an innovative health technology interacts
2) a strategic engagement model for complex ecosystems
3) a competency framework for ecosystem-shaping skills.
A multimethod approach combines ethnography, social network analysis and organizational action research. Training will be sought in healthtech development and commercialization through UC Berkeleys Center for Information Technology Research in the Interest of Society (CITRIS), in sociology of healthcare and innovation through UC Berkeleys Center for Science, Technology, Medicine and Society (CSTMS) and secondment at the Centre de Sociologie de l'Innovation, Ecole des Mines ParisTech (CSI), in social network analysis through UCDs Insight Centre for Data Analytics, in policy/regulatory interactions at UCDs Applied Research for Connected Health Technology Centre (ARCH) and in research translation on secondment at multinational company, S3.";201514,5;201514,5;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;IE;;; 195072;655227;InnoMarket;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Innovation in the road freight transportation chain facilitating sustainability and low cost: A socio-technical perspective on work and development of road freight transport markets.;1/08/2015;31/07/2017;;"InnoMarket is opening the black box of the international road freight transport market, which is organized as a bazaar. The project will investigate this 'institutional order' of road freight transportation that leads to unintended inefficiencies such as less than full truck loads. The objective is firstly to identify innovative potentials for lowering cost and increasing sustainability by analyzing practices of overlapping markets and built-in controversies in the transport chains. Secondly, the project aims at closing a gap in transport research by explaining the low implementation rate of (existing) innovations. Theoretically, the project builds on market making literature and the socio-technical view of innovation processes. An ethnographic action net study is applied to investigate the overlapping markets and international inter-sectoral transport chain actors; the industrial shipper, customer, intermediaries, transporter and drivers. The study involves 50 interviews in Poland, Denmark and Sweden and shadowing actors. The results of the study is a novel perspective on how road transport markets work, contributing to knowledge of transport-chain efficiency, sustainability and innovation that is needed in EU as well as in other parts of the world. CBS research expertise in transportation, constructivist market theory and ethnography advances the fellow in research, methodology and publication. CBS Business-in-Society activities advance the fellow in dissemination; public podcasts; practitioner workshops, and publications. Host professor supervises in transport and logistics research, in workshop method, publication and editorship skill. Secondment at ITD/International Transport Denmarks innovation center offers training-in-innovation projects. Fellow research profile is broadened, including organizing, transportation expertise, ethnographic action net methods, publishing, outreach experience, and an international network of academics and non-academics.";212194,8;212194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;COPENHAGEN BUSINESS SCHOOL;DK;;; 195258;656361;STATE CAPACITY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Neither Dwarf nor Leviathan: Explaining Territorial and Functional Variation in State Capacity;1/07/2016;30/06/2018;;"Citizens live longer, happier lives where states are able to perform their core functions effectively. Even though weak states have received considerable attention from scholars and policy-makers, the concept of state weakness has remained under-theorized. The shortcomings of current conceptualizations are revealed by mounting empirical evidence that (1) state capacity does not extend homogeneously across national territories and (2) that a states capacity to control and coerce citizens is distinct from its capacity to care for them by providing education and public health. Previous work mostly assumed that the reason why states do not exercise coercion and care throughout the territory is simply their inability to do so. This perspective, however, cannot explain why states invest more in building capacity in some regions than in others, or why coercive and caring capacity are geographically uneven. To understand this, it is crucial to acknowledge that states in the developing world can and do invest in building capacity, but are also confronted with the need to ration resources.
This project conducts a subnational comparative analysis of Mexico, which scores well on conventional measures of state capacity, but is perceived by some security experts as critically weak. The projects research aims are twofold:
1) To conceptualize and map intra-country differences on the basis of a new geo-referenced dataset of infrastructure for coercion and care (empirical goal)
2) To theorize and explain the states decision to invest resources in a hospital, school, police station or military barracks in a specific place (analytical goal)
To accomplish these goals, the applicant will participate in advanced training in Geographic Information Systems (GIS) at the University of California, San Diego, a leader for the collection and analysis of spatial data. The acquired skills will strengthen the emerging GIS expertise at the University of Amsterdam, which houses the return phase.";174864,6;174864,6;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITEIT VAN AMSTERDAM;NL;;; 195082;655272;HISTORIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High efficiency GaInP/GaAs Tandem wafer bonded solar cell on silicon;1/06/2015;31/05/2017;;"Direct conversion of photons into electricity is a promising clean energy solution to answer the challenge of energy supply security, competitiveness of the EU industry, electricity prices and climate change. Monocrystalline silicon (c-Si), the dominant technology on the photovoltaic (PV) market, benefits from a strong industry and record power conversion efficiency of 25%, with a cost decreasing every year. However, c-Si technology, mainly limited by material properties, has very little room for efficiency improvement. Much higher efficiencies has been achieved by stacking diodes made of III-V semiconductors; but for cost and availability reasons, the III-V solar cells are restricted to specific markets (space & terrestrial concentration). A hybrid solution combining the advantages III-V multi-junction cells with the benefits of Si, the most wide-spread PV material, offers great opportunities. Indeed, efficiencies up to 35% under 1-sun AM1.5G conditions is expected for a triple junction device based on conventional c-Si cells combined with additional (Al)GaAs and GaInP pn-junctions (4 m of III-V material on top of a c-Si wafer). However the direct epitaxial growth of (Al)GaAs & GaInP on Si is highly mismatched and sufficient material quality has not been achieved so far. The innovative approach proposed in this project bypass the mismatch and enables to combine high crystal quality III-V compounds with Si through wafer bonding: III-V layers are grown lattice matched on GaAs or Ge and then bonded to Si, followed by substrate lift-off & re-use. The validity of the approach has been proven at Fraunhofer ISE with un-optimized GaInP/GaAs//Si triple-junction solar cells with >25% efficiency. This research project, relying on modeling and experimental work to optimize the cell structure (light trapping, bond interface quality, current matching, etc.), targets the significant breakthrough of a GaInP/GaAs//Si triple junction reaching >30% efficiency on large areas (>4cm2).";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;;; 195054;655138;FACADE FIRE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Numerical characterisation of fire growth in external facades and other vertical spaces;15/08/2016;14/08/2018;;"Fire growth through spreading up the faade of high-rise buildings can lead to catastrophic loss of life and property. Faades at times are required to have a fire-resistance rating, for instance, if two buildings are very close together, to lower the likelihood of fire spreading from one building to another. The issue is becoming increasingly critical due to new development trends involving higher buildings and sometime in close proximity to each other and the increasing use of combustible material in faade to raise energy performance of buildings.

The proposed Fellowship is aimed at investigating numerically the behaviour of flames ejected from enclosure fires in external facades and other vertical spaces such as atrium, void spaces and staircases. Full understanding of such external flame behaviour requires insight of the combustion processes within the enclosure. Hence the scope of the research includes enclosure fires to characterise the ejected flames as well as fire growth in faades. The research will take advantage of the abundant experimental data available for model validation. The specific objectives include:

1. Fine tune and validate the open source CFD code FireFOAM , a dedicated LES based solver for fire simulation within the OpenFOAM toolbox for enclosure fires;

2. Investigate the combustion and aerothermodynamics of enclosure fires, including travelling fires;

3. Characterise the spill flame extent, combustion efficiency and heat fluxes inside and outside different enclosures with different openings (office blocks, residential buildings, travelling fires in open plan compartments, etc.);

4. Develop and validate a predictive approach based on FireFOAM for faade fires;

5. Conduct parametric studies for different faade panel materials, spread upwards/downwards to different floors within the building and spread to adjacent buildings in different wind conditions to inform the update of regulatory guidance.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 195107;655423;NIBSAD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electrophysiological markers of cognitive processes and neuroplasticity in healthy ageing and Alzheimer`s disease;1/11/2015;31/10/2017;;Ageing of the European population is increasing prevalence of age-related diseases such as Alzheimers disease (AD). AD is considered a public health priority due to socio-economic costs and limited efficacy of current pharmacological treatments. Co-registration of electroencephalogram (EEG) and transcranial magnetic stimulation (TMS) is a novelty, non-expensive and non-invasive approach to obtain surrogate markers of cognitive decline. Moreover, repetitive TMS (rTMS) is considered a promising tool to induce neuroplasticity and improve cognitive functions. The main objective of this research is providing markers of brain activity, reactivity, connectivity and plasticity related with healthy and pathological ageing (i.e., early AD). Thus, samples of healthy young, healthy elderly and AD patients will perform a behavioural task (to study visuospatial attention and cognitive control processes) while carrying out EEG recording and online EEG/TMS co-registration. Correlates of brain activity (event-related brain potentials), reactivity (amplitude of TMS evoked potential -TEP) and connectivity (TEP topography, coherence, synchronization, and graph theoretical analysis of complex networks) will be obtained before and after of delivering offline rTMS. It will allow studying differences in cortical responses induced by rTMS on each group of participants, which will provide correlates and biomarkers of brain plasticity related with age and AD. These biomarkers will allow the identification of individuals at early stages of AD and evaluating efficacy of novel TMS treatments. Importantly, identification of rTMS parameters responsible to induce neural plasticity and improve cognitive functions will contribute to develop rehabilitation protocols for AD patients.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI;IT;;; 195105;655417;GATTACA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genetics of Alternative Transcript Abundance upon immune Cellular Activation;1/10/2015;30/09/2017;;The human body is constantly exposed to infectious agents. Efficient immune response is therefore fundamental to protect the cells from infection and keep individuals healthy. Still, extreme variations are observed in the efficiency of immune response among individuals and populations. Recently, the dissection of the genetic bases of the host immune response to infection has fostered a large interest in the scientific community. As a result, there is now a growing understanding of the influence of genetic variation on the transcriptional reprogramming of immune cells during infection. However, it is now widely accepted that the underlying one geneone protein paradigm is overly simplistic and cannot account for the full complexity of the transcriptome. Here, we propose to study how genetic variants affect transcript diversity to modulate the response to pathogens at the individual and population levels. To do so, we will seek to identify genetic variants that have conferred a selective advantage to human populations through modulation of isoforms usage in response to infection. This work will rely on an innovative strategy that combines coexpression-based studies of the isoform regulatory networks with analysis of the genetic determinants of splicing in response to infection. In doing so, this study should improve our understanding of isoform regulation and identify novel regulatory elements and splicing factor-target relationships in the specific context of infection.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT PASTEUR;FR;;; 194890;653670;USE-IT;SIGNED;H2020-EU.3.4.;MG-8.2b-2014;H2020;Users, Safety, security and Energy In Transport Infrastructure;1/05/2015;30/04/2017;;"The transport network across Europe faces challenges relating to carbon reduction targets, energy security, and depletion of natural resources, without sacrificing its efficiency and compromising mobility. In addition, the road and rail infrastructure in particular are ageing and require renewal. Simultaneously, advances in sensors, mobile communications, smart ticketing and big data offer the potential for customers to become an active part of the transport operations system and have the information to make decisions for transport to enable mode agnostic personal and business travel and for freight operators to have more resilience and better reliability in their systems.
The European transport system faces also an unavoidable societal challenge, which is achieving new levels of resource-efficiency, environmental-friendliness, safe and seamless transport for the benefit of citizens, the economy and society.
In order to tackle the challenges and reap the benefits outlined above, infrastructure owners and transport operators will be required to work together, along with other crucial stakeholders, to share knowledge and cooperate in a way that will be beneficial to all parties, and this proposal seeks to facilitate this.
The objective of this project is to better understand the common challenges experienced across transport modes, bring representatives of transport modes together to share experience and skills and to develop a set of common research objectives. The project will draw upon the experience gained from the Joint European Transport platform with the focus on infrastructure operations, and will also focus on research objectives presented in the Forever Open Road programme and the work of the FORx4 - Forever Open Road, Railway, Runway and River A Cross-modal transport initiative for research for which FEHRL produced a Point of View document.";955624,72;955624,72;H2020-MG-2014_SingleStage_B;CSA;FORUM DES LABORATOIRES NATIONAUX EUROPEENS DE RECHERCHE ROUTIERE;BE;"EURNEX e. V.;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;INSTYTUT BADAWCZY DROG I MOSTOW;LABORATORIO NACIONAL DE ENGENHARIA CIVIL;INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS, DE L'AMENAGEMENT ET DES RESEAUX;SERVICE TECHNIQUE DE L'AVIATION CIVILE;TRL LIMITED";"DE;AT;PL;PT;FR;UK"; 195248;656323;BaCTher;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Bacteria for Cancer Therapy;1/11/2015;31/10/2017;;"Cancer is the second cause of death in the western world and it is expected to become the leading one in developing countries in the next future. The long-term outcome of BaCTher is the improvement of the cancer treatment that can overcome the intrinsic limitations of the current therapies through the development of a new promising therapeutic strategy. The specific hypothesis behind the proposed research is that an attenuated Salmonella enterica serovar Typhimurium (STM?znuABC) is able to influence the tumor microenvironment (TME) reprogramming or re-educating the immune response, and inducing a shift from protumorigenic inflammation to anticancer immunity, which results in a tumor growth control.
This hypothesis is based on the observation that: 1) there is compelling scientific evidence of the effect of bacteria, and in particular Salmonella, against cancer growth; 2) STM?znuABC is able to reduce cancer growth and to increase the average life expectancy in a mammary adenocarcinoma Balb/c mice model; 3) STM?znuABC is able to penetrate and proliferate into the tumor cells inhibiting the proliferation of tumor cells at 24h post-treatment.
Three specific aims are designed to:
1) investigate the relationship between STM?znuABC and TME;
2) characterize the mechanism of STM?znuABC antitumor activity;
3) validate the results obtained in the preliminary studies using alternative in vivo models.
The Experienced Researcher (ER), from the Istituto Superiore di Sanit (ISS), Italy, will spend one year at the Cancer Immunobiology Section of the Cancer and Inflammation Program (CIP), Center for Cancer Research (CCR), division of the National Cancer Institute (NCI), Bethesda, MD USA, for mutual exchange of skills and know-how that will be transferred back to the beneficiary organisation (ISS), contributing to the establishment of a wider long-term collaboration between the ER and host institutions.";164203,8;164203,8;H2020-MSCA-IF-2014;MSCA-IF-GF;ISTITUTO SUPERIORE DI SANITA;IT;;; 194929;654091;CO2NOR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Carbon dioxide storage in nanomaterials based on ophiolitic rocks and utilization of the end-product carbonates in the building industry;1/09/2015;31/08/2017;;Anthropogenic activities have increased atmospheric CO2 concentrations, which are considered to be the main cause of global warming. The EU has set itself targets for reducing its greenhouse gas emissions progressively up to 2050. A popular proposed solution to this crucial problem is carbon capture and storage (CCS). Ophiolitic rocks are considered among the most promising lithotypes for CO2 storage due to their high reactivity and many exposures in the world. In this proposal, an innovative and sustainable method for ex situ mineral carbonation will be suggested that will ensure the safe storage of CO2. This method includes the creation of novel nanomaterials via the ball milling process, based on low-cost ultramafic and mafic rocks from the Troodos ophiolite (Cyprus), which is considered as the most complete ophiolite worldwide. Although numerous studies have been carried out on the petrogenetic evolution of the Troodos ophiolite, a systematic work about the applicability of these rocks for CCS will be done for the first time in this study. Fines and waste material from quarries in the wider Troodos area will also be used for the development of nanomaterials. It is anticipated that ball milling will accelerate the kinetics of rock-fluid reactions during the carbonation procedure. Hence, carbonate minerals, which are stable over geological timescales, will provide a safe long term CCS solution. Additives will also be tested in the nanomaterials in an attempt to increase their CO2-storage capacity. The proposal also involves applied research in the form of exploitation of the end-product carbonates in the building industry. The successful outcome of this project will be based on the researchers extensive experience in the study of mafic and ultramafic ophiolitic rocks and mineral carbonation, as well as on supervisors expertise in the fields of nanomaterials and CCS.;151648,8;151648,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF CYPRUS;CY;;; 194908;653909;ICT4COP;SIGNED;H2020-EU.3.7.;FCT-14-2014;H2020;Community-Based Policing and Post-Conflict Police Reform;1/06/2015;31/05/2020;;The challenges of international police reform assistance are formidable. Conventional top-down institutional reform has proven neither effective nor sustainable. Community-based policing (COP) holds promise, however evaluations have pointed to a lack of in-depth understanding of police-community relations in police reform assistance. This project will conduct integrated social and technical research on COP in post-conflict countries in S.E. Europe, Asia, Africa and Central America. New knowledge, reflection on lessons learnt and best practices will support both national police and EU/International police reform assistance. The project will lead to a better understanding of police-community relations, and innovation in information and communication technology (ICT) for enhancing these relations in post-conflict countries undergoing serious security reform. Linking social and technological research, the project will study social, cultural, human security, legal and ethical dimensions of COP to understand how citizens and police can develop sustainable relations with the use of ICTs. We will explore how technological innovation can support COP in crime reporting and prevention. The project will explore ICT solutions to facilitate, strengthen and accelerate positive COP efforts and police-citizen interactions where trust levels are weak. Solutions will depend on the context and identified needs of end-users: communities, local police, national and international police (EU/UN), and policymakers, and may include citizen reporting, information monitoring, mobile value transfer, or improved organizational systems. The project includes a Policing Experts Network whose role is to support research planning, and dissemination and exploitation of findings, grounding the research in police practice. This will ensure findings are communicated by engaged police practitioners, and directly applied in COP education and training curricula in Europe and case countries.;4999999;4999998;H2020-FCT-2014;RIA;UNIVERSITETET FOR MILJO OG BIOVITENSKAP;NO;"NORWEGIAN MINISTRY OF JUSTICE AND PUBLIC SAFETY;NORSK UTENRIKSPOLITISK INSTITUTT;University of Durham;APPLIED INTELLIGENCE ANALYTICS LIMITED;NORSK INSTITUTT FOR BY- OG REGIONFORSKNING;HOGSKOLEN I OSLO OG AKERSHUS;UNIVERSITAET BREMEN;UNIWERSYTET JAGIELLONSKI;RUHR-UNIVERSITAET BOCHUM;SOCIAL IMPACT LAB CIC";"NO;UK;IE;DE;PL"; 194991;654733;FOC4SIP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Functionalised Organic Complexes for rapid Sensing of Industrial Polluters;7/07/2015;6/07/2017;;"The ultimate target of the project is to create and transfer knowledge on the development of novel functionalised macromolecular complexes for rapid sensing of hazardous industrial polluters.
Recent developments of macromolecular complexes and opto-electronic techniques of their study have enabled advances in the formation of molecular probes able to recognize molecules and metal ions. These advances are currently being considered for application in a new generation of sensor technology, and opto-electronic methods have been proved as sensitive and rapid tools for such detection. However the selectivity and sensitivity of such methods requires further improvement. Here, we propose new detection systems combining use of functionalised macromolecules and development of sensor devices by novel micro-fabrication tools as well as training and career development of prospective researcher up to mature Senior Scientist level.
The overall objective of this research is to select and characterise sensor/probe macromolecules (polymethine dyes, functionalised carbon nanomaterials, melanins), then to optimise mechanisms of detection due to interaction of macromolecules with industrial polluters, and finally to develop sensing devices. Performance and usability of the novel sensors will be evaluated in collaboration with industrial partner.
This is an ambitious research initiative having strong interdisciplinary approach that combines physics, chemistry, materials science, engineering, and biology. Its success is upheld by combination of complementary expertise of the Fellow, Host and Partners in preparation and characterisation of functionalised macromolecules as well as development of sensing devices.
The project will provide benefits in monitoring and detection of hazardous compounds, and optimisation of cleaning routine after industrial pollution. Therefore, positive impact on safety of ambient environment and public health care sector is anticipated.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 195029;654987;PADWIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Power Amplifier Design for Wideband Communications;1/09/2015;31/08/2017;;"Power amplifier (PA) design for wideband communications is a hot topic in electronics, since microwave PAs with high linearity, efficiency and bandwidth represent an enabling technology for wireless/mobile communications enhancement.
The proposal aims to develop the clipping contours method in continuous modes PAs. The continuous modes provide sets of harmonic loads that can be exploited to achieve high efficiency operation of the active device. The clipping contours permit to broaden these sets of harmonic loads, relaxing the requirements on matching networks but still controlling the target PA performance. The host laboratory recently published cutting-edge results on both methods.
The candidate will work to achieve important objectives:
-Extension the theory of clipping contours to third and higher harmonics
-Creation of a novel design tool for clipping contours in continuous modes
-Development of matching network synthesis techniques to achieve the loads provided by the tool
-Design of PAs prototypes for high power base stations in the 1.8-2.7 GHz band
-Embedding of clipping contours in a Doherty PA prototype
They will be achieved thanks to the host laboratory excellence, to the young and promising researchers ability, and to an effective planning. Each step will follow a solid procedure:
-Literature survey and theoretical formulation of the method
-Implementation of novel method by design examples
-Experimental characterization for validation
-Exploitation: dissemination and public engagement
The project is of great relevance. It will impact on the industrial leadership of EU: microwave PA is an enabling technology in many competitive markets. Power efficient base stations will contribute to the EU target of increasing overall energy efficiency. The project will provide to the researcher the skills and the scientific impact to boost his career trajectory. The host will benefit of the project, increasing its reputation and acquiring skills from the candidate.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CARDIFF UNIVERSITY;UK;;; 195026;654981;GUIDES;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;GUideline Implementation with DEcision Support systems;15/07/2015;14/07/2017;;"Healthcare based on the best available clinical evidence can lead to better quality of care. Evidence-based guidelines are potentially important instruments, but clinicians often do not adhere to them.
A computerised decision support system (CDSS) is a technology that uses patient-specific data to provide relevant medical knowledge at the point-of-care. It is considered to be an important quality improvement intervention and EU member states are recommended to prioritise investment in it. However, the significant investments do not consistently result in value for money due to content and implementation issues.This project aims to improve the impact of CDSS through better content wise development and optimised implementation. Our objectives are to (1) investigate the factors that determine successful CDSS implementation, (2) develop tools to address these factors and (3) validate the utility of these tools through the development of a tailored CDSS intervention. We also (4) develop a protocol for a cluster randomised controlled trial on the effectiveness of the tailored CDSS intervention. We selected the conservative management of knee osteoarthritis as a prototype condition for the pilot. Ultimately, the better implementation of CDSS may lead to better informed decisions and improved care and patient outcomes for a wide range of conditions.
This project integrates expertise from multiple scientific domains and builds upon the leading expertise from the consortium in major projects (GRADE, DECIDE, TICD). The planned research and training will lead the fellow to an essential new specialist role for the successful implementation of CDSS and will be the start of an international multidisciplinary career.
The project is a response to the Horizon 2020 health priorities on transferring knowledge to clinical practice, individual empowerment for self-management of health, scalable innovation actions, better use of health data, treating chronic diseases, and active ageing.";208400,4;208400,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NASJONALT KUNNSKAPSSENTER FOR HELSETJENESTEN;NO;;; 195057;655150;BARREN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bioenergetics in Arid Environments;1/08/2015;31/07/2017;;Arid environments are habitats of energetic stringency because of extreme air temperatures and periods of decreased food and water abundance. Typically, birds confronted with these conditions reduce their energetic metabolism to be in balance with local resources. The ability to adjust energetic metabolism to face the harshness of arid habitats has been a significant question in ornithology and ecological physiology for decades. Recent evidence indicates the important role of the mitochondrial oxidative phosphorylation pathway OxPhos in this process. However, an effort to combine microevolutionary and physiology concepts remains to be attempted. The current advances in avian genomics combined with my background in ornithology, ecology and evolution provide the best opportunity to study adaptation to arid environments. In BARREN, I propose to integrate ecological properties of an arid environment with variation at OxPhos-related genes, and energy metabolism at cellular and organismal level in a sophisticated systems approach that, to the best of my knowledge, has never been attempted. Through placement at Copenhagens Centre for GeoGenetics, I will have access to one of Europes leading research groups in avian genomics. A short secondment at the University of Angers will confer additional training in avian physiology. BARREN offers an exceptional opportunity for me to expand on my previous knowledge through implementing a multidimensional and cutting-edge approach centred on genome-level data, in order to advance our understanding of bioenergetics in arid habitats. This project is not only pivotal for basic evolutionary research, but is relevant for one of the key issues of Horizon2020: prepare excellent scientists to address one of the major societal concerns: Fighting and adapting to climate change.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 194975;654521;MOSUDO;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Water and Drug Mobility at Silica Surfaces probed with DOSY NMR;1/04/2015;31/03/2017;;Europes pharmaceutical industry is faced with the multitude of lead compounds that are discarded during their development phase. One of the hurdles of most promising drugs is that they have difficulties reaching their site of action in the human body. This insufficient bioavailability results from the complex, poorly understood interplay between drug molecules, water and the surfaces of drug delivery materials and cell membranes. To tackle this challenge, a paradigm shift that recognizes water as headline act is proposed. The physical properties of water drastically change when approaching solid surfaces or cell membranes. Nobel Prize winner Albert Szent-Gyrgyi even described life itself as water dancing on the tune of solids. This research proposal aims to gain understanding of water and drug molecule mobility near silica surfaces. Silica materials in recent years popped up as most promising materials for drug delivery. Unravelling the complex interplay between drug, water and silica surfaces will equip pharmaceutical scientists with a generic toolbox to enhance the bioavailability of newly developed drug candidates. MOSUDO research focuses on probing the mobility of water, amino acids with varying hydrophilicity and a peptide drug in contact with silica. Diffusion-Ordered Nuclear Magnetic Resonance spectroscopy (DOSY NMR) is living spectacular developments and revolutionary sensitivity improvement. This project will take advantage of this development of DOSY NMR to investigate the complex molecule-water-surface interplay with new eyes. Fellowship applicant Dr. Randy Mellaerts can rely on a strong interdisciplinary background in surface chemistry and pharmacy. Acquiring in-depth technical expertise in DOSY NMR and its direct application in pharmaceutical industry will complement his current research profile and allow him to embark at the highest scientific level in a for society very important research area.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195243;656298;ViGOTHIC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards a typology of Visigothic script: the Beatus British Library Add. 11695 and its potential for dating and localising Visigothic script manuscripts;1/09/2015;31/08/2017;;"The main aim of the proposal is to establish a point of reference for the analysis of Visigothic script, the primary carrier of Latin writing in the Iberian Peninsula from the 8th to the 14th centuries. To date, most palaeographical analysis of Visigothic script has been conducted using a traditional methodology and following heterogeneous criteria, which has led to subjective results difficult to share or evaluate. In contrast, my research will create a computerised database of quantitative data by applying a specially designed method, a starting point that will allow codices written in Visigothic script to be described, compared and placed in their socio-cultural context. Innovative techniques for digital analysis of manuscript sources that will be acquired in the host institution will allow me to gain new insights into the analysis of the script while opening new avenues of research by applying digital tools to its study. The knowledge thus generated will be of great practical importance for future palaeographical and textual research establishing criteria upon which advanced studies can build. It will offer a means of understanding the script, its manuscripts, and its cultural context.
The study builds on the systematic analysis of one of the few codices written in this script that can be dated and geographically located with certainty: the copy of the Apocalypse of Beatus of Libana kept at the British Library (Add. 11695). I aim to achieve six specific objectives:
A) Manual palaeographical study: (1) to determine how many scribes intervened in the copy of the codex, their graphic characteristics, (2) evolution, and (3) cultural context.
B) Digital palaeographical study: (4) to apply and evaluate computer-assisted techniques to the study of Visigothic script, (5) their viability and benefits, (6) to establish a point of reference for computerised analysis of Visigothic script codices by providing accurate graphic foundations to foster historical research.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KING'S COLLEGE LONDON;UK;;; 195039;655035;RhomBioID;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular mechanisms of rhomboid-like proteins in human immunity;7/04/2015;6/04/2017;;"The immune system coordinates vital responses against a plethora of threats. It relies on well-described signalling networks via soluble proteins and cell-to-cell contacts. The secretory pathway traffics all secreted and surface proteins, but the mechanism of how immune cells control this process is unclear.
Rhomboid-like proteins are a family of polytopic intramembrane proteins serine proteases and pseudoenzymes found in all organisms. Most eukaryotic rhomboid-like proteins regulate the fate of proteins in the secretory pathway. The rhomboid protease RHBDL4 is reported to regulate ER associated degradation (ERAD). The rhomboid pseudoenzyme, iRhom2, is essential for the trafficking and maturation of TACE, and subsequent TNF release in response to inflammatory stimuli in myeloid cells. Little is understood about the mechanism of how these rhomboid-like proteins regulate trafficking.
I hypothesise that RHBDL4 regulates signalling networks in myeloid cells, similarly to iRhom2. Indeed, according to my preliminary data, RHBDL4 and iRhom2 are both expressed in human myeloid cells, and are induced by interferon gamma, a modulator of signalling networks in immunity.
In this project, I aim to provide cell biological and mechanistic insight into RHBDL4 and iRhom2 regulation of signalling networks in human immunity. I will identify new interactors of RHBDL4 and iRhom2 via a novel biochemical screen called BioID. Candidates will be validated using conventional cell biological methodologies and a new interaction assay called M-Track. I will confirm these interactions in a quasi-physiological context, using a human ex vivo macrophage system. The biological significance of the interactions will be studied using detergent-permeabilised cellular systems of human macrophages. My focus on human rhomboids and immunity integrates a very timely area of fundamental cell biology with a topic of direct relevance to human health.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194956;654260;FLUNOVELTY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Development of novel fluorinated reagents for preparation of drugs.;1/11/2015;31/10/2016;;"Around 20% of all modern drugs are fluorinated organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical reagents and reactions towards drug-like compounds.
In this project, we will address this issue by discovering novel small fluorinating reagents - fluorinated diazoalkanes, - elaborate their practical reactions, and use this knowledge to develop alternative synthetic approaches to some known drugs (AS-136A, Celecoxib).";92538;92538;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;REGIE ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLE;FR;;; 195067;655194;CANCER-TECH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cervical cancer detection platform based on novel laser processing;1/01/2016;31/12/2017;;"About 10% of all cancers diagnosed in women worldwide, are cancers of the cervix, the organ that connects the uterus and the vagina. Alone in the European Union over 16,000 deaths are reported annually due to cervical cancer effecting women mainly between the ages of 25 and 50.
Within the scope of this fellowship, hosted by Dublin City University (Ireland) in collaboration with Arrows Biomedical GMBH (Germany), a highly sensitive platform to detect Human Papillomavirus (HPV), causative agent of about 99.7% of cervical cancer, will be developed. The proposed diagnostic platform will be based on a laser textured biopolymer as device substrate, functionalized with nanoparticles produced via the Pulsed Laser Ablation in Liquid (PLAL) technique. This on-chip immunoassay will allow rapid detection of the HPV. The novelty of this project lies in the high-quality bio-nanostructures as nano-labels via PLAL designed for ultrasensitive detection of HPV.
Two major aspects of this project are: (1) the development of complex nano-labels specifically targeting high risk HPV; and (2) improvement in the performance of the developed assay increasing their sensitivity and specificity, relative to current start of the art.
Ultrapure HPV-specific nano-labels will be prepared using pulsed laser ablation in liquid, a green synthesis route independent of any chemical processing. The proposed technique is advantageous due to the enhanced surface activity of laser-generated nanoparticles, which will reduce the amount of sample molecules needed for the successful detection by improving the limit of detection and overall detection time. This project aims at making substantial contribution to the advancement of cancer immunosensing based on a novel on-chip immunoassay design for medical applications. Through this project, the applicant aims to develop intellectual property related to the manufacturing of biomedical devices via laser processed surfaces.";175866;175866;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DUBLIN CITY UNIVERSITY;IE;;; 194976;654532;NANO-Q;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cavity Cooling of Nanosilicon for Quantum Interference Experiments;16/05/2015;15/05/2017;;"The ability to control and exploit the virtues of quantum physics is expected to revolutionize many areas of science and technology, from quantum information processing to quantum enhanced metrology. However, it is still a great challenge to observe quantum effects, such as superposition, in truly macroscopic objects. Matter-wave interferometry with very massive particles is a promising route towards testing the notions of macroscopicity and the still speculative limits of linearity in quantum physics.
An intriguing goal in the community is to control the motion of mesoscopic nanoparticles, from 10^7 to 10^10 a.m.u., to the point where quantum interference can be observed. In this mass range collapse models and the role of gravity in quantum theory can be explored. It is a great challenge to control the motion of objects larger and more complicated than atoms and simple molecules. Recent proposals and experiments have begun the task, using optical cavities to cool the motion of nanoparticles, aiming to reach the level at which quantum effects are evident. The feasibility of this goal has been demonstrated experimentally by the Host Group, the Experienced Researcher and others, driven and supported by theoretical work.
The NANO-Q project aims to create a source of free cavity cooled nanoparticles suitable for mesoscopic matter wave interferometry. It would be a great scientific breakthrough to observe quantum effects with such massive objects. Cooled nanoparticles will also be of great technological importance, as quantum transducers and precision force sensors.";166156,8;166156,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAT WIEN;AT;;; 195233;656243;PERFECTION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Probing mechanisms of pathogen effector recognition by plant Resistance proteins to elevate defence gene activation;1/04/2016;31/03/2018;;"Plant cells tightly regulate gene transcription in response to a changing environment. Stresses, such as pathogen encounters, lead to dramatic transcriptional reprogramming to favor defence activation over basal cellular functions. For effective defence, cells must rapidly alter defence gene mRNA abundance. How extracellular and intracellular recognition of plant pathogens trigger appropriate changes in host mRNA abundance is poorly understood. Upon recognition of pathogen effectors, resistance proteins activate plant defence by unknown mechanisms. My host lab recently reported that the Arabidopsis Resistance gene pair RPS4/RRS1-R elevates expression of certain defence genes, such as those required for salicylic acid biosynthesis, within four hours of detecting PopP2 effector in Arabidopsis. The main goal of this proposal is to understand how effector recognition by RPS4/RRS1-R leads to rapid defence gene induction. We will test the hypothesis that RPS4/RRS1-R proteins directly interact with gene loci that are activated during this process. I will use transgenic Arabidopsis that carry a single genome locus with independently epitope-tagged RPS4, RRS1 and other defence-implicated proteins to investigate: (1) changes in composition of the RPS4/RRS1-R protein complex upon effector recognition using mass spectrometry; (2) effector-induced changes in association of the RPS4/RRS1-R proteins with induced genes using chromatin immunoprecipitation; (3) changes in chromatin status at induced gene regions correlated with gene induction and activation of defence by RPS4/RRS1-R. From this project, I will rigorously test an important model, namely that plant immune receptor complexes directly mediate transcriptional reprogramming of defence genes through chromatin changes upon recognition of effectors. I bring highly complementary expertise in genetics and transcriptional regulation of basal defence from China to Canada and now to TSL that is essential for this projects success.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE SAINSBURY LABORATORY;UK;;; 195092;655331;PALEO-AGRI;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;agroPastoral Activities and effects on Landscapes and ErOsion dynAmics in the alps:a new insight from Geological appRoaches and lake sedIment DNA;1/06/2015;31/05/2017;;Due to their unique biological and geological resources, mountains have attracted humans since prehistoric times, despite their sensitivity to environmental and climatic changes. Few studies, however, have investigated the detailed history and dynamic of alpine agro-pastoral activities or their impacts on plant cover and erosion. This is largely due to the lack of suitable proxies for human activities in these environments. The PALEO-AGRI project proposes to address this challenge: 1) through the optimization of a powerful and innovative tool, DNA metabarcoding, and 2) its application to archaeological layers and lake sediment archives distributed across elevation and latitudinal gradients in the French Alps in order to investigate how human-climate-environment relations evolved in diversified environments.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of York;UK;;; 195090;655295;NLRs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechanisms of natural auto immunity triggered by plant NLR immune receptors;1/09/2015;31/08/2017;;Resistance (R) loci with nucleotide binding/leucine rich repeat (NB-LRR or NLR) domains have been identified as the major causal genes for hybrid necrosis, which presents an extreme example of the trade-off between plant growth and the activation of immune system. This is an exciting finding both for plant breeders and plant pathologists. However, how these NLR proteins or even the whole NLR family lead to hybrid necrosis, how they contribute to fitness under natural conditions, and how this is reflected in their extreme sequence variation remain largely unknown. In this proposal, I plan to exhaustively explore their function by systematically knocking out the NLR loci from genome of different Arabidopsis accessions using genome editing, and testing their fitness performance in the natural habitat. I will also reveal the cellular and biochemical mechanisms by which NLR proteins inappropriately interact with other cellular proteins to cause hybrid necrosis and compare the hybrid necrosis activity with pathogen induced immunity.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 194914;653963;Aggregation selection;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Genome-wide screen of aggregation selection;1/08/2015;31/07/2017;;"As protein aggregation is associated with numerous neurodegenerative diseases, several groups study the mechanism of aggregation formation and its regulation within the cell. However, besides the association with disease, some aggregates also have a functional purpose, e.g. temporary storage of hormones. This suggests that the outcome on cell fitness is determined by the relative contribution of aggregation formation, and its effect: either loss-of-function or gain-of-function.
Previous genome-wide screens already identified important processes to maintain proteome stability, but none of these quantifies the origin of the aggregation effect or considers that aggregation could be beneficial for the cell. Knowledge of how each of these are regulated, is essential to obtain a complete model of the aggregation process.
Recently, the host lab developed a unique method, based on a population genetics approach using yeast, that is able to simulate these toxic and beneficial effects triggered by the aggregation process. By exploiting this model using knock-out studies, I will determine the impact of each knock-out on cell fitness, quantify what is contributing to this effect (e.g. gain-of-function) and decipher how the knock-out influences the protein aggregation process. This knowledge will allow us to explore new drug targets in order to control protein aggregation.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 195014;654915;ALifeInSOFCs;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Augmented Lifetime of Infiltrated Solid Oxide Fuel Cells;1/09/2015;31/08/2017;;Solid oxide fuel cells (SOFCs) are one of the most promising technologies to produce electricity in a clean and efficient way. However, their practical application is still limited by detrimental degradation during operation as a consequence of convoluted chemical, mechanical and microstructural deterioration processes, occurring especially at the anode when hydrocarbon fuels are used. This project aims to assess the electrode microstructural degradation through a combined experimental/modelling approach consisting of accelerated ageing tests, impedance spectroscopy analysis, tomographic reconstruction of samples, particle-based algorithms and electrochemical model simulations. Infiltrated cermet anodes are considered in the study, due to their well-defined microstructure that allows them to be, at the same time, a good model platform to assess the microstructural evolution and a high performing alternative for SOFC applications. The synergic integration of experimental activities, microstructural characterization and model simulations is expected to identify and quantify the underlying mechanisms of microstructural degradation (e.g., particle coarsening and agglomeration) and to suggest strategies to enhance the durability of infiltrated electrodes (for example, by adding a controlled amount of ceramic nanoparticles to limit the coarsening of metallic particles within the electrode). The project, combining the researcher's expertise in microstructural and electrochemical modelling with the competences in testing and tomographic characterization at the host institution, is expected to be a pillar in the researcher's academic career while significantly contributing to boost the European excellence in a cutting-edge and multidisciplinary topic such as the fabrication and characterization of efficient and durable solid oxide fuel cells.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195011;654908;PFCCMS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pattern Formation in Catalytic Colloidal Microswimmers;1/04/2015;31/03/2017;;"Self-propelled particles such as bacteria, or 'Janus colloids' partially coated with catalyst, consume energy from their environment and convert it into systematic motion. Interacting ensembles of these particles compose so-called active matter which is intrinsically driven out of thermodynamic equilibrium. This allows for a rich and unusual phenomenology that includes condensation and phase separation in systems with purely repulsive interactions; giant density fluctuations; and various types of self-organized structure formation whose origin lies beyond the equilibrium principle of entropy maximization (free energy minimization). In PFCCMS we propose a novel theoretical study of activity-induced pattern formation with active colloids, addressing the interplay of an anisotropic production of chemicals at the colloidal surfaces and a chemotactic coupling of the particles to the resulting chemical gradients. Careful inclusion of noise within our coarse grained descriptions will enrich the emerging self-organized spatiotemporal structures with phenomena based on nucleation and topological defects. Our findings are expected to inform design principles for activity-induced self-organization of soft materials; we also plan to link them with the physics of gene-surfing and the spatiotemporal organization of bacterial colonies.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 195228;656148;PRENET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Social Networking and Raw Material Selectivity in Early Prehistoric Mediterranean Seascapes;1/09/2015;31/08/2017;;"The PRENET proposal aims at investigating the geographical extent, directionality and intensity of social communication in the early prehistory of the Eastern Mediterranean seascape and the cognitive/behavioural factors behind the observed patterns.

The specific scientific objectives of the proposal are:
1) the investigation of social interactions in Eastern Mediterranean through the examination of raw material movement in early prehistoric Cyprus, and
2) the determination of cognitive/behavioural elements behind our ancestors choices of specific raw materials, through the study of raw material selectivity.

Misconceptions abound with regard to the eastern part of the Mediterranean and especially the island of Cyprus with current notions seeing the sea as a barrier to early human presence. However, given its geographical location and its complex ecology and habitats this lack of human presence in Cyprus seems to be researchrelated rather than factual. The PRENET project aims at firmly putting such theories to rest by establishing the scales of raw material movement and communication networks in the Eastern Mediterranean. Drawing from her previous work, where the Experienced Researcher developed a social network model for the investigation of the scale of past social life, she will address this phenomenon by looking at lithic raw material movement in early Cypriot archaeological sites. The Fellowship will be an excellent opportunity for her career diversification by training-through research and her further development towards professional maturity.";151648,8;151648,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF CYPRUS;CY;;; 195042;655075;FAST-RAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Structure-function studies of the human FASTK family of mitochondrial proteins with putative novel RNA binding domains the helical FAST motifs and the small RAP domain;1/10/2015;30/09/2017;;The purpose of this project is three-fold. The main aim is to elucidate the structure of two novel RNA binding folds: the helical FAST motifs and the small RAP domain that are predicted in the Fas-activated Serine/Threonine Kinase (FASTK) protein family. To this purpose, I will employ protein crystallography and small angle X-ray scattering to obtain models of FASTK proteins and their domains. The second objective is to understand the function of the FASTK family of mitochondrial RNA-binding proteins that were originally annotated as atypical kinases. The eponymous FASTK engages in processes similar to its interaction partner, the post-transcriptional regulator TIA-1, whereas some of the other five human paralogs are necessary for cellular respiration. I will use purified FASTK proteins to study their enzymatic activities and RNA-binding properties in vitro, which should clarify their functional classification as kinases or post-transcriptional regulators. Additionally, follow-up studies may include validation of the findings through informed mutagenesis, identification of RNA targets, protein partners, and selected phenotypes in RNA biology. The final goal of this project is to enable a young researcher to establish herself as an independent researcher, creating a group which will focus on mitochondrial RNA-binding proteins and employ X-ray crystallography as the main tool. Altogether, this interdisciplinary project will 1) Impact various fields of research, such as structural and RNA biology 2) Has the potential for applications in human health due to the connections of the FASTK family to mitochondrial and inflammatory diseases, 3) Significantly develop the career of a talented researcher and 4) Contribute to the academic and research excellence at the University of Warsaw by establishing a new research group, introducing structural biology expertise, and bringing together local and international collaborations.;134462,4;134462,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIWERSYTET WARSZAWSKI;PL;;; 194961;654384;ASCENT;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;Access to European Nanoelectronics Network;1/05/2015;30/04/2019;;"ASCENT will provide access to the worlds most advanced 10 nm and beyond-CMOS nanoelectronics data and test structures in Europes leading nanofabrication research institutes. The institutes involved have extensive advanced semiconductor processing fabrication facilities, flexible nanofabrication facilities, advanced electrical characterization equipment and expertise in atomistic and TCAD modeling. This will be the first time that access to these state-of-the-art devices and test structures will be available anywhere in the world. The impact of this access, and the resulting advances that will be made, will contribute significantly to competitiveness and growth capacity in the Europes nanoelectronics industry.

ASCENT will enable Europes world-leading atomic scale device, TCAD and compact modeling community to perform the systematic studies that are required to develop nanoscale design methodologies and to identify the impact of quantum effects on sub-10 nm device performance.

ASCENT provides an interface to global industrial leaders in nanoelectronics through the Industry Innovation Committee and through activities designed to transfer IP and technology uptake from the supported research activities. The results from the access activities will be fed back to device manufacturers to future improve the nanoscale devices being developed.

ASCENT will reach out to the research community through a co-ordinated marketing campaign and will offer a simple single access route to the advanced technologies provided. ASCENT will provide technical and logistical support to Users and the results of the Access activities will be published and shared at User Workshops enabling strong interaction between the Users and Providers.

ASCENT is a unique opportunity for researchers in Europe to gain access to world-leading technologies that are being developed in Europes leading institutes and ensure Europe remains at the forefront of global nanoelectronics development.";4698623,75;4698623,5;H2020-INFRAIA-2014-2015;RIA;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;"COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM";"FR;BE"; 194875;653590;AUGGMED;SIGNED;H2020-EU.3.7.;FCT-07-2014;H2020;Automated Serious Game Scenario Generator for Mixed Reality Training;1/06/2015;31/05/2018;;The aim of AUGGMED is to develop a serious game platform to enable single- and team-based training of end-users with different level of expertise from different organisations responding to terrorist and organised crime threats. The platform will automatically generate non-linear scenarios tailored to suit the needs of individual trainees with learning outcomes that will improve the acquisition of emotional management, analytical thinking, problem solving and decision making skills. The game scenarios will include advanced simulations of operational environments, agents, telecommunications and threats, and will be delivered through VR and MR environments with multimodal interfaces. This will result in highly realistic training scenarios allowing advanced interactivity while encouraging security staff and first responders to engage and actively participate in the training process. In addition, the AUGGMED platform will include tools for trainers enabling them to set learning objectives, define scenarios, monitor training sessions, modify scenarios and provide feedback in real-time, as well as evaluate trainee performance and set training curricula for individual personnel in the post-training session phase. Finally, the platform will be offered in affordable and cost-effective Modes including Basic Mode (low VR fidelity and interactivity through mobile devices), Intermediate Mode (immersive multimodal VR) and Full Mode (immersive multimodal MR On-Site).;5535673,75;5535673,75;H2020-FCT-2014;RIA;BMT GROUP LTD;UK;"ISRA-TEAM 98 LTD;Ferrocarrils de la Generalitat de Catalunya;UNIVERSITY OF GREENWICH;THE UNIVERSITY OF BIRMINGHAM;PIRAEUS PORT AUTHORITY SA;POLICE AND CRIME COMMISSIONER FOR WEST YORKSHIRE;SERCO BELGIUM SA;SISTEMA D'EMERGENCIES MEDIQUES;GEOMOBILE GMBH;SHEFFIELD HALLAM UNIVERSITY;KARDARAS KONSTANTINOS;UNIVERSIDAD POLITECNICA DE MADRID;Ministry of Citizens Protection";"IL;ES;UK;EL;BE;DE"; 194893;653729;Unity;SIGNED;H2020-EU.3.7.;FCT-14-2014;H2020;Unity;1/05/2015;30/04/2018;;The Unity vision is to strengthen the connection between the police and the diverse communities they serve to maximise the safety and security of all citizens. The end-user focus of Unity shall identify best practices in Community Policing (CP) through primary and secondary research to enhance cooperation between Law Enforcement Agencies (LEAs) and citizens through the development and live pilot demonstrations of technological tools in six EU member states that facilitate, strengthen and accelerate community and LEAs communications. These tools shall be amplified and supported by the design and delivery of CP training and awareness raising activities to LEAs, citizens and community partners, including online virtual communities. Unity will provide LEAs with a new CP model and shared framework of governance and enabling tools and technology to support closer cooperation for greater, more effective and efficient and more inclusive CP. The citizen-centred approach of Unity support the combined protection, safety, security and well-being of communities, but it will also support a more collective, shared ownership of large scale, collective risk. Coordinated by pioneers and practitioners in CP, Unity seeks new ways of working in which the police will serve as a catalyst for change within communities, helping the latter to become an integral part of the solution, and thereby sharing the ownership and delivery of a sustainable CP model which simultaneously embraces the benefits of technology while meeting diverse community needs. This new and sustainable citizen-centred CP model will have community trust and confidence at its heart, with the ability for two-way flows of information and communication to allow for greater understanding of the problems and issues faced by communities. By working with citizens and community stakeholders to arrive at a full understanding of their concerns, targeted interventions and solutions can be agreed to keep local communities safe;4538120;4330900;H2020-FCT-2014;RIA;POLICE AND CRIME COMMISSIONER FOR WEST YORKSHIRE;UK;"Politsei- ja Piirivalveamet;TREELOGIC TELEMATICA Y LOGICA RACIONAL PARA LA EMPRESA EUROPEA SL;SERVICE PUBLIC FEDERAL INTERIEUR;University of Dundee;EDINBURGH NAPIER UNIVERSITY;EUROPEAN INSTITUTE FOUNDATION;POLIISIAMMATTIKORKEAKOULU;SERCO BELGIUM SA;POLICIJSKA AKADEMIJA;ERASMUS UNIVERSITEIT ROTTERDAM;HOCHSCHULE FUR DEN OFFENTLICHEN DIENST IN BAYERN;UNIVERSITY ST KLIMENT OHRIDSKI BITOLA;SHEFFIELD HALLAM UNIVERSITY;RINICOM LIMITED";"EE;ES;BE;UK;BG;FI;HR;NL;DE;MK"; 195075;655238;Human Rpc5;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;RNA Polymerase III Rpc4/Rpc5 subcomplex and Selenocysteine tRNA transcription;1/05/2015;30/04/2017;;"In higher eukaryotes, the RNA polymerase III (Pol III) participates in the transcription of small RNAs such as the tRNAs. RNA polymerase recruitment to their specific promoter relies on the activity of several transcription factors. Brf2 is a transcription factor that exclusively recruits RNA Pol III at the selenocysteine tRNA (tRNASec). Unpublished work from our group has unravelled an unanticipated central role of Brf2 in the oxidative stress response pathway, by acting as a cellular blockade during prolonged oxidative stress.
We are interested in understanding the molecular determinants that govern RNA Pol III recruitment at tRNASec promoter and its interaction with Brf2-bound promoters. In general, RNA Pol III subunits size is conserved amongst the eukaryotic kingdom. However, an exception is the human Rpc5 subunit, whose C terminus has 450 residues that are not present in its yeast counterpart C37. Similarly to Brf2, the Rpc5 C-terminal extension is only present in higher metazoans, which suggests a phylogenetic link between these two proteins. The recruiting mechanism of RNA Pol III to Brf2-dependent promoters has not been described to date. Preliminary results in our lab provide evidences that indeed Rpc5 C terminus is responsible for the accurate recruitment of RNA Pol III at TBP/Brf2/DNA complex. Interestingly, structural homology predictions indicated that the human Rpc5 C-terminal extension is a eukaryotic homologue of the prokaryotic protein SelB, a factor that interacts with the tRNASec and with a specific region of mRNAs, the SECIS-element, during translation of SeCys containing proteins. This similarity suggests a regulatory role for Rpc5 C terminus in the interaction with the SECIS-element and/or the tRNASec.
Our main objectives are to determine the structure of the Rpc5 C terminus in isolation and in complex with Brf2/TBP/DNA by X-ray crystallography and to characterise the role of Rpc5 C terminus in the context of tRNASec transcription.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUTE OF CANCER RESEARCH - ROYAL CANCER HOSPITAL;UK;;; 195024;654967;NMOSPEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Experimental Nuclear Magneto-Optic Spectroscopy;1/10/2015;30/09/2017;;"This project aims at building a world-unique instrument for measuring novel nuclear magneto-optic spectroscopy (NMOS) phenomena. In NMOS, the differential optical response to polarized nuclear spins is probed. The project aims at observing effects both in the dispersive spectral range, such as Nuclear Spin-induced Cotton-Mouton effect in strong magnetic field (NSCM-B) and Nuclear Quadrupole-induced Cotton-Mouton effect (NQCM), as well as phenomena in the absorptive range such as Nuclear Spin-induced Circular Dichroism (NSCD). The possibility to measure the nuclear magneto-optic effects both in and out of optical resonance, in both Faraday and Voigt geometries and by using either thermal nuclear spin polarization or the more sensitive induced hyperpolarization, offers an advantage over the already established set-ups.
The results obtained using the constructed apparatus will serve to prove the existing theoretical predictions of the NMOS phenomena. The ultimate goals are the observation and measurement of the novel NMOS effects as well as the assessment of their ability to resolve chemically different nuclear sites via nucleus-specific response. The proposed techniques offer advantages such as the ability to focus on a particular functional group and to gain local high-resolution information, the use of optical detection and thus, increased sensitivity and resolution over the (in principle) similar Nuclear Magnetic Resonance (NMR). Additionally, NMOS will provide access to new physical observables offering different kinds of localized information than conventional NMR.
These achievements will in the future have a potential for opening a wide array of applications of the NMOS effects as high-resolution analytical spectroscopic techniques in molecular and materials research, with prospects to be used in molecular and life sciences and on the industrial scale.";179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;OULUN YLIOPISTO;FI;;; 195052;655135;CircaDopamine;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Role of Dopamine in the Regulation of Sleep and Circadian Rhythms;1/07/2015;30/06/2017;;"Alterations in sleep/wakefulness behavior are among the most debilitating and highly prevalent non-motor symptoms of many neurological and psychiatric disorders that originate from perturbations of the Dopamine (DA) system. Currently, no effective therapeutic strategies are available to alleviate these symptoms. Inspired by my Ph.D results, the current proposal aims to investigate in detail the role of dopamine in the regulation of sleep and circadian rhythms. The main question under investigation is; By what mechanisms DA regulates sleep and circadian rhythms and how are these affected in diseases (such as Parkinson)? Two transgenic mouse models will be used; the first model (MitoPark) shows, like in Parkinsons disease (PD) patients, a progressive age-dependent neurodegeneration of DA neurons. The second model (CircaDA) lacks functional clock gene oscillations selectively in DA neurons. Using polysomnography in MitoPark mice, a detailed investigation of the consequences of DA loss on sleep regulation will be performed. In-vivo multiunit electrophysiology will be used in both mouse models to study the role of the circadian changes in DA neurotransmission in driving and/or synchronizing the electrophysiological properties of striatal and cortical neurons. Finally, selective DA receptor drugs will be combined with in-vitro patch clamp electrophysiology and in-vitro Per2-bioluminescence to investigate the molecular pathways used by DA to modulate multiple electrophysiological correlates of clock gene oscillations. Collectively, this proposal holds promising fundamental and translational insights for sleep problems experienced by patients suffering from DA-related disorders and is expected to significantly contribute in fostering the academic career of the researcher and the competences of the hosting laboratory in Neurodegenerative diseases.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ACADEMISCH ZIEKENHUIS LEIDEN;NL;;; 195077;655240;Terra-Micro-Carbo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Effect of land use induced shifts in soil microbial diversity and function on carbon cycling in soil;14/07/2015;13/07/2017;;"The need for improved food production for the growing population has led to increase in planets arable land cover. Many studies suggest that such practices lead to loss of soil organic carbon (C) a relatively large C pool with a fast response time. Thus there is a need to manage soils sustainably in order to mitigate atmospheric CO2 levels while maintaining agricultural productivity. Soil microorganisms act as gatekeepers for soil-atmosphere C exchange by regulating the storage and release of organic C in soil. However, there is a lack of understanding on how land use induced shifts in soil microbial diversity affects this regulation; necessitating detailed research on the underpinning microbial mechanisms. The project objective is to discern the effects of land use on microbial diversity in differing soil types and to investigate whether this shift has implications for C cycling (do certain microbial groups have a greater capacity for soil C accumulation?). To address these objectives an interdisciplinary approach merging molecular biology and isotope chemistry will be employed. Soil from long-term grassland-arable paired sites will be used to assess differences in microbial biodiversity and functional gene abundance through DNA next-generation sequencing. In addition, a field incubation experiment with 13C labelled substrates will be performed to investigate the variable tracer incorporation into different microbial functional groups. This will be measured using novel magnetic bead capture hybridization of RNA from specific groups followed by its 13C analysis using liquid chromatography-isotope ratio mass spectrometry. The novelty of this project is that it aims to provide direct evidence to prove diversity-function linkages and gain mechanistic understanding of the physiological responses of soil microbial communities to land use change. The resulting knowledge will help better predict changes in soil C and thus improve prognosis of climate change feedbacks.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATURAL ENVIRONMENT RESEARCH COUNCIL;UK;;; 194999;654816;Cancer-Drug-Screen;SIGNED;H2020-EU.1.1.;ERC-PoC-2014;H2020;High-throughput drug screening for identifying personalized cancer treatments tailored to the particular mutations of the patients tumor;1/04/2015;30/09/2016;;"Cancer is caused by a series of genetic alterations that confer an advantage to cancer cells, leading to uncontrolled growth. However, each tumor exhibits distinct molecular changes, making each patients malignancy unique. Hence, in the personalized medicine era, cancer treatment aims to tailor the most suitable treatment for each patient according to his/her genetic background, tumor acquired mutations and clinical indications.

The p53 tumor suppressor is the most frequently mutated gene in human cancers, with thousands of different tumor-associated mutations reported. Many such cancer-associated mutations in p53 lead to loss of its tumor suppressive activity and in some cases, to gain of new oncogenic functions, resulting in tumor recurrence and enhanced patient mortality. Importantly, tumors with different p53 mutations exhibit specific cancerous phenotypes and do not respond to particular treatments.

Based on our ERC-funded breakthrough technology, where we made a library of ~10,000 distinct p53 variants, and based on our strong IPR offering and competitive advantages, here we propose to develop three products for determining which treatment (or combination) would be most effective for treating a patients tumor according to his specific p53 sequence, reducing excruciating side effects and improving treatment outcomes:
1) Offering patients/physicians a list of treatments ranked by their efficacy in treating cells of similar origin and p53 mutations to those present in the patients tumor, allowing them to make more informed treatment decisions.
2) Offering companies in the personalized cancer treatment field access to our existing proprietary data regarding treatment efficacies towards p53 genetic variants.
3) A service to drug developing companies that applies our technology for testing the efficacy of a client-supplied drug of interest over all ~10,000 p53 mutations in our library in a cell-line of choice.";150000;150000;ERC-2014-PoC;ERC-POC;WEIZMANN INSTITUTE OF SCIENCE;IL;;; 194945;654173;PWP;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Power and Powerlessness;1/10/2015;;;"The project Power and Powerlessness (PWP) is a theological study of the concept of power. Many scholars have observed that the concept of power remains contested and often neglected. The absence of a theoretical grasp of the concept is even more striking in Christian theology. Churches in the Global North evidence considerable discomfort over the idea of power: to avoid the charge of colonial imposition of their world-view; due to conflicts over authority within the churches; or to dissociate from the dominant political order. In the Global South, however, the vibrant Neo-Pentecostal and Charismatic movements celebrate the immediacy of the power of the Spirit. What needs to be better understood are the resources contained within the Christian tradition to make sense of competing claims about the nature and significance of power, particularly given that existing literature does not often address these issues in a sustained manner. The fill this gap, the project is organized into four work packages: WP1: Early, Medieval and Early Modern Christian concepts of power; WP2: contemporary theological treatments of power; WP3: Power in contemporary social theory; WP4: the completion of a monograph entitled 'Power and Powerlessness: a theological analysis'. In addition to this major study, the project will produce: five journal articles, four workshops for church leaders, three columns for church newspapers, three academic conference presentations, a project website, and a new collaborative research grant application with the Scientist in Charge. The Experienced Researcher will not only benefit from training in research project management and grant writing, but will also be mentored in Historical, Systematic and Roman Catholic theology, as well as Philosophy of Religion, and will enhance his existing German language skills. The host institution will benefit particularly from the ERs highlighting of issues of power as he contributes to its existing research projects.";171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;DE;;; 195218;656094;StillNoFace;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Identity matching from still images without face information;1/09/2015;31/08/2017;;In computer vision, human identity matching from images and/or video has been an active research topic for more than two decades and its popularity is increasing with the increase in computing power. The state of the art techniques are based on face images and gait recognition from long video sequences. However, in many real applications only some static images of the subject may be available where face information is missing (e.g. posterior views). These scenarios have not been addressed by the research community as they are difficult to handle. In this action, we propose a method for matching identities from a set of 2D images of a person without any facial information. The method consists of two steps: at first, the human body is modelled by a 3D articulated model whose pose is estimated by its 2D projections onto the images. Then, biometric features are computed by fitting 3D deformable models to the image data, thus capturing the form and size of the main parts of the anatomy. The overall framework works under a probabilistic framework, with a learning step, in order to encode pose and anatomy variations between a set of individuals that are to be identified.;168391,8;168391,8;H2020-MSCA-IF-2014;MSCA-IF-GF;PANEPISTIMIO IOANNINON;EL;;; 194996;654796;SAAB;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;'Science as Applied to Building' : Science, Construction, and Architectural Acoustics (1914-1954);1/07/2015;30/06/2018;;The aim of this Fellowship is for the researcher, Dr Fiona Smyth, to develop the professional prowess, advanced training, interdisciplinary skills, high-impact dissemination, and practical experience commensurate with a leading independent researcher in the EU. The remit of the Fellowship research falls under the categories of history of science, history of construction and architectural acoustics. The researcher will be based for two years in the Dept. of the History of Science in Harvard University, working under the supervision of Professor Peter Galison. The third year of the Fellowship will be completed in the Acoustics Research Group in the School of Engineering, Trinity College Dublin (TCD) working under the supervision of Professor Henry Rice. Research training will be implemented through an interdisciplinary project investigating the 20th century emergence of architectural acoustics as a branch of modern building science in Britain and Ireland. On the outgoing phase of the Fellowship the researcher will access expertise, advanced training and mentoring in the History of Science. No Irish university has yet established a dedicated History of Science department. In the return phase the researcher will consolidate the knowledge and experience gained in the US through advanced laboratory training in acoustics. In TCD she will be given the opportunity to embed her new knowledge in the design of interdisciplinary curricula for graduate students. Under the guidance of international experts, she will acquire an invaluable skill-set bridging humanities, science and technology with implications for contemporary societal and economic application. The resources of the host departments will facilitate development of an interdisciplinary and international academic network as well as career mentoring. The Fellowship will establish the researcher firmly at the centre of interdisciplinary research in the histories of building science and architectural acoustics.;266063,4;266063,4;H2020-MSCA-IF-2014;MSCA-IF-GF;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;IE;;; 195211;656193;mini-liver SCCS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Human mini-liver stem cell culture systems: from mechanisms behind liver cancer origin and recurrence to new therapeutic treatments;20/04/2016;19/04/2018;;Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. But at present, there are no good in vitro models for HCC. Thus, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive HCC pathogenesis and there are only limited therapeutic options. In this project, our aim is to establish and characterize physiologically relevant 3D-liver cancer stem cell models and use them to increase our understanding of the mechanisms behind liver cancer with the final goal to develop anti-cancer strategies.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194899;653789;REFINET;SIGNED;H2020-EU.3.4.;MG-8.1b-2014;H2020;REthinking Future Infrastructure NETworks;1/05/2015;30/04/2017;;Launching a European long-term ambition and initiative to increase the overall performance of multimodal transport infrastructures, the REFINET CSA intends to 1) create a sustainable network of European and international stakeholders representatives of all transport modes and transport infrastructure sectors, 2) deliver a shared European vision of how to specify, design, build or renovate, and maintain the multimodal European transport infrastructure network of the future along with innovative processes so as to enhance the effectiveness of the sector, and 3) elaborate a Strategic Implementation Plan with a comprehensive set of prioritised actions to made the REFINET vision a reality as well as providing private and public decision makers with a set of up-to-date recommendations and guidelines (including good practices and lessons learnt) for strategic actions and required levels of cooperation between all stakeholders. REFINET will consider two complementary scenarios, namely maintenance and upgrading of existing transport infrastructures, and development of new transport infrastructures. REFINET will contribute to create a European-wide consensus on where to focus in terms of research and innovation to improve the productivity of the assets (reducing maintenance costs, extending the life span) and reduce drastically traffic disruptions of transport flows from inspection, construction and maintenance activities, and to accommodate increasing/changing traffic demand. Thus, REFINET will pave the way to enhanced technology integration and transfer and mass-market development for innovative materials, components, systems and processes supporting the pan-European generalisation of advanced multimodal infrastructures, handling the demand within various industrial sectors and help match the EU-2020 Strategy, and achieve goals of main stakeholders. The REFINET consortium is made of 8 partners from 5 European countries (Spain, France, Italy, Belgium, United Kingdom).;998235,51;998235,51;H2020-MG-2014_SingleStage_B;CSA;CENTRE SCIENTIFIQUE ET TECHNIQUE DU BATIMENT;FR;"FORUM DES LABORATOIRES NATIONAUX EUROPEENS DE RECHERCHE ROUTIERE;FUNDACION TECNALIA RESEARCH & INNOVATION;D'APPOLONIA SPA;FUNDACION PLATAFORMA TECNOLOGICA ESPANOLA DE LA CONSTRUCCION;DRAGADOS SA;UNION INTERNATIONALE DES CHEMINS DE FER;OVE ARUP & PARTNERS INTERNATIONAL LIMITED";"BE;ES;IT;FR;UK"; 194941;654156;RItrain;SIGNED;H2020-EU.1.4.2.2.;INFRASUPP-3-2014;H2020;Reseach Infrastructures Training Programme;1/09/2015;31/08/2019;;There has never been a greater need for skilled managers and operators of research infrastructure (RI). Europe must develop the workforce that will turn ~50 nascent RIs with sites in different countries into powerhouses of support for major projects comparable to understanding the blueprint of life or discovering new subatomic particles. RItrain will develop a flagship training programme enabling RIs across all domains to gain expertise on governance, organisation, financial and staff management, funding, IP, service provision and outreach in an international context. It will be designed and delivered by experts who have set up and managed RIs from concept to maturity. We will define competencies required by RIs through consultation with their senior managers. The resulting competency framework will underpin a Bologna-compliant degree, the Master in Research Infrastructure Management, with three delivery routes. (1) Professionals working in RIs (or organisations representing them) can dip into the content, focusing on areas where there is most need. (2) Management teams can take the course as an organisation, dividing modules between them to gain a certificate for the RI. This will flag the RI as an organisation that values staff development, improving its attractiveness as an employer. (3) Recent graduates and others wishing to enhance their employability can take a full masters degree. Course content will include webinars led by senior managers of RIs. A staff-exchange programme will catalyse exchange of best practice and foster cooperation to develop a mobile work force effective across many RIs. By the end of the project we will be delivering a masters curriculum funded through course fees. Others with an interest in adopting it will be encouraged to do so, providing a means of expanding the programme. Europes research community and global collaborators will gain from world-class facilities to support excellent, high-impact research to benefit humankind.;1995633,75;1995633,75;H2020-INFRASUPP-2014-2;CSA;Biobanking and Biomolecular Resources Research Infrastructure - European Research Infrastructure Consortium;AT;"MEDIZINISCHE UNIVERSITAET WIEN;UNIVERSIDADE DO MINHO;EUROPEAN MOLECULAR BIOLOGY LABORATORY;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;EATRIS ERIC;INFRAFRONTIER GMBH;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;EUROPEAN RESEARCH INFRASTRUCTURE CONSORTIUM FOR THE SURVEY OF HEALTH, AGEING AND RETIREMENT IN EUROPE;UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA;USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE;ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK";"AT;PT;DE;UK;NL;FR;IT;CZ"; 194878;653626;microMole;SIGNED;H2020-EU.3.7.;FCT-05-2014;H2020;SEWAGE MONITORING SYSTEM FOR TRACKING SYNTHETIC DRUG LABORATORIES;1/09/2015;31/08/2018;;"The threat of synthetic drugs is one of the most significant current drug problems worldwide. Amphetamine-Type Stimulants (ATS) are the second most widely used drugs. Since 1990, ATS manufacturing has been reported from more than 70 countries worldwide and the figure keeps rising. In 2008, 80 % of the amphetamine production facilities dismantled worldwide were located in Europe (UNODC, 2010) (EMCCDA, 2011). Organised Crime Groups are involved in ATS large-scale production (Europol, 2007) (EMCDDA, 2009). Since 2011, the wide availability of pre-precursors (like APAAN) significantly lowered the price of the controlled precursor BMK and caused severe environmental problems, taking the problem to a greater dimension.

The aim of this project is to design, develop and test a prototype of a system for legal recording, retrieving and monitoring operations of ATS and ATS precursor laboratories in urban areas. The sensor system will be installed within the sewage system and will track waste associated to ATS production. Criminal investigators and forensic specialists will use the system in case of:
1. initial general suspicion of ATS production in a certain area, for locating laboratories by monitoring the sewage system for long time periods;
2. strong suspicions that in a well confined area ATS is being produced, for collecting material for forensic analysis and potential use in court, and for aiding in the planning of LEA raid operations.


The ?Mole prototype will contain the following features: a) miniaturized system for 200mm sewage pipes, b) robust housing taking into account sewage system environment, c) minimized power consumption, d) enhanced operation time supported by energy harvesting, e) high-specificity electro-chemical sensors, f) integrated micro-tanks for sample storage, and g) secure GSM and radio communications for remote monitoring. Analysis of privacy law, data protection and social acceptance will be carried on at different stages.";5451387,79;4992866,33;H2020-FCT-2014;IA;POLITECHNIKA WARSZAWSKA;PL;"BLUE TECHNOLOGIES SP ZOO;BUNDESKRIMINALAMT;STICHTING KATHOLIEKE UNIVERSITEIT BRABANT;UNIVERSITEIT GENT;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;CAPSENZE HANDELSBOLAG;UNIVERSITE CLAUDE BERNARD LYON 1;JGK TECH EHF;UNIVERSITAET DER BUNDESWEHR MUENCHEN.;CENTRALNE LABORATORIUM KRYMINALISTYCZNE POLICJI";"PL;DE;NL;BE;SE;FR;IS"; 195027;654984;PreFlexMS;SIGNED;"H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-03-2014;H2020;Predictable Flexible Molten Salts Solar Power Plant;1/06/2015;31/05/2018;;"Predictability and flexibility are key enablers to increase CSP penetration in the energy mix by a) increasing dispatchability b) making CSP less/not reliant on subsidies c) supporting stable grid operation d) enabling operators to access new revenue streams (electricity trading, ancillary services). Today CSP plants with molten salt storage only partly achieve these objectives. Key enabling technologies to be demonstrated and introduced in the market are 1) design and operation of molten salt once-through steam generator This will allow fully flexible plant operation; 2) design and implementation of integrated weather forecasting and dispatch optimization This will allow optimal management of the energy storage to maximize revenues while respecting constraints/commitments (e.g. to the grid). Towards 1), an innovative design approach is proposed, integrating process and equipment design with dynamic simulation of the system. Proven technologies in separate fields (molten salt; once-through steam generator; optimum control) will be for the first time integrated and demonstrated. Towards 2), different approaches to DNI forecasting (direct; mesoscale models) will be integrated to extend geographical coverage and improve reliability. Dispatch optimization under conditions of uncertainty (weather forecast) and perturbations (e.g. grid support requests) will be developed. Furthermore, automatic plant performance characterization by machine learning will be implemented to ensure a real optimum is achieved. For succesfull market introduction, a down-scale pilot will be realized. Here, integrated operation of once-through steam generator, weather forecast and dispatch optimization will be demonstrated. CSP will undergo large growth in developing markets, where grid constraints and market liberalization will play a role. Developint these key-enabling technologies will put european industries in the position to compete at the forefront in the market worldwide.";17688612,8;14362194,2;H2020-LCE-2014-2;IA;ALSTOM POWER SYSTEMS;FR;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;SOLARGIS SRO;AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE;S.T.F. SALVATORE TRIFONE E FIGLI SPA;ESE ENGINEERING SERVICES FOR ENERGY S.R.L.;GENERAL ELECTRIC (SWITZERLAND) GMBH;UNIVERSIDADE DE EVORA;AGENCIA ESTATAL DE METEOROLOGIA;ALSTOM RENEWABLE (SCHWEIZ) AG;FUNDACION CENER-CIEMAT;EC SYSTEMS AMC SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA;POLITECNICO DI MILANO;Universitaet Stuttgart;EC SYSTEMS SPZOO";"DE;SK;PL;IT;CH;PT;ES"; 194860;653409;TOXI-triage;SIGNED;H2020-EU.3.7.;DRS-02-2014;H2020;INTEGRATED AND ADAPTIVE RESPONSES TO TOXIC EMERGENCIES FOR RAPID TRIAGE: ENGINEERING THE ROADMAP FROM CASUALTY TO PATIENT TO SURVIVOR.;1/09/2015;31/08/2019;;"The seven specific objectives of TOXI-triage address the operational; technological; ethical and societal dimensions of CBRN response and recovery, and importantly the economic base from which sustainable CBRN and multi-use systems are derived.
19 partners in 4 Task forces will deliver 9 Work Packages (WPs) that address: end user specifications; Design and delivery; Test and Validation; and, Impact. The approach defines a concept of operations that envisages accelerated delivery of situational awareness through an ensemble of embedded sensors, drones, standoff detectors (including cameras), artificial intelligence for processing sensor signals and web-traffic from social media, and centralised command and control. Wireless traceability of casualties provides dynamic mapping including medical care. 2 field exercises are intended to test and verify the operational attributes of the systems, and 3 WPs focus on impact to deliver: Exploitation; Security and Ethics; and Effective Innovation Management.
Distinctive technological attributes of TOXI-triage include: rapid non-invasive assessment of exposure/ injury through monitoring metabolic markers of injury; managing and exploiting the semantic web; traceability by design; aptamer-based bio-sensing; casualty-to-discharge system integration; and integrated environmental and stand-off hazard designation. The approach is rigorous with clinical trials to test systems in poisoning clinics and live agent tests in laboratories designated by the UNs OPCW.
Distinctive societal attributes of TOXI-triage include: addressing the needs of all vulnerable groups; optimising inter-cultural/ethnic messages and needs in CBRN response; fostering economic impact by multiple-uses for all the projects systems. TOXI-triage intends that its outcomes will be used routinely in medical/environmental/urban and search and rescue emergencies. The benefits are intended to extend significantly further then enhanced CBRN resilience";12931869,25;11966510,5;H2020-DRS-2014;IA;LOUGHBOROUGH UNIVERSITY;UK;"Prometech BV;JYVASKYLAN YLIOPISTO;HELSINGIN YLIOPISTO;MINISTRY OF NATIONAL DEFENCE, GREECE;UNIVERSITAET PADERBORN;HASICSKY ZACHRANNY SBOR MORAVSKOSLEZSKEHO KRAJE;THE UNIVERSITY OF EDINBURGH;ENVIRONICS OY;NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA;Helmholtz Zentrum fr Umweltforschung GmbH - UFZ;Oslo universitetssykehus HF;T4I ENGINEERING LTD;G.A.S. GESELLSCHAFT FUR ANALYTISCHESENSORSYSTEME M.B.H.;Airsense Analytics GmbH;ATOS SPAIN SA;GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER;MIKKELIN KAUPUNKI";"NL;FI;EL;DE;CZ;UK;NO;ES"; 194957;654359;eLTER;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;European Long-Term Ecosystem and socio-ecological Research Infrastructure;1/06/2015;31/05/2019;;"A collective effort is needed to create the environmental research infrastructure for answering pressing questions in a world of rapid social, economic and environmental change.
The overall aim of the eLTER project is to advance the European network of Long-Term Ecosystem Research sites and socio-ecological research platforms to provide highest quality services for multiple use of a distributed research infrastructure.
eLTERs major objectives and methods are to:
(1) identify user needs for the research infrastructure in relation to major societal challenges through consultations with scientific, policy and business stakeholders and horizon scanning;
(2) streamline the design of a cost-efficient pan-European network, able to address multiple ecosystem research issues, in collaboration with related global and European research infrastructures, e.g. LifeWatch;
(3) develop the organisational framework for data integration and enable virtual access to the LTER data by enabling data publishing through distributed Data Nodes and by providing access to data on key research challenges through a Data Integration Platform;
(4) foster the societal relevance, usability and multiple use of information, data and services through new partnerships with the providers of remotely sensed data, analytical services and scenario testing models, and via the adoption of new measurement technologies.
The LTER-Europe network and the European Critical Zone community will collaborate to achieve these goals. 162 sites in 22 countries will provide data on long-term trends in environmental change, some reaching back 100 years. Test cases using these data will address a range of environmental and social issues to push innovation in network level services and steer conceptual developments.
The envisaged LTER Infrastructure will enable European-scale investigation of major ecosystems and socio-ecological systems, and support knowledge-based decision making at multiple levels.";4999138;4999138;H2020-INFRAIA-2014-2015;RIA;UMWELTBUNDESAMT GMBH;AT;"FUNDACAO DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA FP;SUOMEN YMPARISTOKESKUS;MASINOTEK OY;HELSINGIN YLIOPISTO;INSTITUTE OF LANDSCAPE ECOLOGY OF THE SLOVAK ACADEMY OF SCIENCES;INSTITUT PO BIORAZNOOBRAZIE I EKOSISTEMNI IZSLEDVANIYA BALGARSKA AKADEMIYA NA NAUKITE;FORSCHUNGSZENTRUM JULICH GMBH;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;UNIVERSITATEA DIN BUCURESTI;GEOHIRES INTERNATIONAL GMBH;Helmholtz Zentrum fr Umweltforschung GmbH - UFZ;MAGYAR TUDOMANYOS AKADEMIA OKOLOGIAI KUTATOKOZPONT;BEN-GURION UNIVERSITY OF THE NEGEV;SVERIGES LANTBRUKSUNIVERSITET;UNIVERZITET U NOVOM SADU;EUROPEJSKIE REGIONALNE CENTRUM EKOHYDROLOGII POLSKIEJ AKADEMII NAUK;SENCKENBERG GESELLSCHAFT FUR NATURFORSCHUNG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;ZNANSTVENORAZISKOVALNI CENTER SLOVENSKE AKADEMIJE ZNANOSTI IN UMETNOSTI;CONSIGLIO NAZIONALE DELLE RICERCHE;GISAT S.R.O.;RIJKSUNIVERSITEIT GRONINGEN;THE RESEARCH COMMITTEE OF THE TECHNICAL UNIVERSITY OF CRETE;BIOSENSE INSTITUTE - RESEARCH AND DEVELOPMENT INSTITUTE FOR INFORMATION TECHNOLOGIES IN BIOSYSTEMS;VLAAMS GEWEST;LATVIJAS UNIVERSITATES AGENTURA LATVIJAS UNIVERSITATES BIOLOGIJAS INSTITUTS;UNIVERSIDAD DE GRANADA;NATURAL ENVIRONMENT RESEARCH COUNCIL";"PT;FI;SK;BG;DE;ES;RO;HU;IL;SE;RS;PL;FR;SI;IT;CZ;NL;EL;BE;LV;UK"; 195009;654906;ALHIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Archaeology, Landscapes and Heritage in the Iberian Southeast;1/06/2015;31/05/2017;;This training-through-research project at the Institute of Heritage Sciences of the Spanish National Research Council (Incipit-CSIC), aims both to generate new scientific knowledge on the archaeology of the landscapes and the socio-political processes of the Final Iron Age and the Early Roman period, and to enhance their value for cultural heritage management and development in Murcia, in the Spanish Southeast. In this sense, this proposal aims to create a fruitful link between the applicants historical and archaeological research background and skills and the opportunities to learn and to develop a heritage outreach project. The interest of the project is due to both, the lack of landscapes studies which focus on the Iron Age in this region from a diachronical and landscape perspective, and the remarkable socio-political transformations undergone by the local communities in the period between the 5th and the 1st centuries BC. The landscape will be here understood like expression of the social and political interactions, but also like a space with an active role in their development, at different levels. All the evidences will be compiled, for the first time, through an interdisciplinary methodology (archaeological record, ancient texts, paleoenvironmental data, integration in a GIS, etc.) and will be analysed from a contextualized and comparative European perspective, which the regional research in this period lacks. Results will be disseminated by means of several impact publications but also beyond the strictly scientific environment, with the support of the host centre, the regional museums and other institutions. Regarding the heritage perspective this project aims to allow the applicant to learn how to re-direct all this knowledge towards a proper and effective management and communication of the important and rather unknown heritage value of those sites.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195060;655161;Q-METAPP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum Metrology in Applications;1/04/2015;31/03/2017;;Quantum technologies will soon change the way we communicate, compute and measure phenomena. Due to the industry-oriented research in quantum metrology, methods have already been demonstrated that allow to perform measurements with unprecedented precisionslimited only by the quantum structure of nature. In recent years, new sophisticated techniques have been developed to more accurately describe such quantum metrological protocols and, in particular, account for the noise effects inevitably present in their implementations. The main objective of Q-METAPP is to propose a new generation of noise-robust sensing technologies by utilising these novel tools, and furthermore study their potential use in other branches of quantum information theory. The action will involve state-of-the-art theoretical research at the frontiers of quantum physics, statistics and probability theory, with its major part dedicated to designing quantum optical experiments. It will require strong collaboration between many theoreticians, also from other European institutions, and direct consulting with the experimental groups. The main goal will be achieved by proposing atomic magnetometry setups, in which the noise effects can be eliminated due to the careful engineering of the apparatus geometry, and by exploring the so-called Quantum Zeno Effect intrinsic to quantum systems. Moreover, multi-parameter estimation scenarios will be studied, in order to design quantum-enhanced protocols allowing to simultaneously sense many parameters in photonic experiments. In the second part, open problems in quantum thermodynamics, non-Markovian dynamics and communication theory will be approached with use of the metrological tools. Last subproject will focus on explaining the fundamental role of quantum correlations in metrology. The action, having a substantial impact on the development of quantum technologies, will greatly increase future mobility and career advancement possibilities of the applicant.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 195012;654911;THALAMODEL;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multimodal, high-resolution modeling of the thalamus for neuroimaging studies: application to dyslexia;1/06/2015;31/05/2017;;"The thalamus is a brain structure that is responsible for important functions (e.g., sensory systems, sleep, the motor system, spoken language) which are distributed over its 12 nuclei . While recent advances in MRI technology have made it possible to image the thalamic nuclei in vivo, the lack of specific computational tools to analyze the images forces most research studies to either treat the thalamus as a single structure (limiting the spatial specificity of the analysis) or to rely on the excruciating process of manually labeling the data. Since very few sites currently possess the anatomical expertise and staffing resources to carry out studies based on manual delineations, the lack of tools to analyze MRI data of the thalamus is hampering progress in different branches of neuroscience.

Here we present an interdisciplinary project to build tools to automatically analyze the thalamic nuclei in MRI data. The tools will be based on a statistical atlas of the thalamus built upon ultra-high resolution MRI and histological data from autopsy samples. We will use the tools in a study of the relation between thalamus and dyslexia, where they promise to increase our understanding of the pathology by testing which nuclei are affected and to what extent. In addition, the tools will be distributed as part of the software package FreeSurfer, allowing its over 10,000 worldwide users to carry out cognitive neuroscience experiments at the nucleus level, and to discover new imaging biomarkers of other diseases related to the thalamus, e.g. Alzheimer's, Parkinson's, MS and ALS.

This project will allow the host to acquire knowledge in medical image analysis from the applicant and to establish collaborations with Harvard and Oxford (host of the proposed secondment). The project will also expand the applicants research network and train him in areas (ex vivo MRI, psycholinguistic studies) that complement his image analysis skills, preparing him for a future faculty position.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE;ES;;; 195203;656024;EcoSwing;SIGNED;"H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-03-2014;H2020;EcoSwing - Energy Cost Optimization using Superconducting Wind Generators - Worlds First Demonstration of a 3.6 MW Low-Cost Lightweight DD Superconducting Generator on a Wind Turbine;1/03/2015;28/02/2019;;"EcoSwing aims at world's first demonstration of a superconducting low-cost, lightweight drive train on a modern 3.6 MW wind turbine.

EcoSwing is quantifiable: The generator weight is reduced by 40% compared to commercial permanent magnet direct-drive generators (PMDD). For the nacelle this means a very significant weight reduction of 25%. Assuming series production, cost reduction for the generator can be 40% compared to PMDD. Finally, reliance on rare earth metals is down by at least two orders of magnitude.

This demonstration is enabled by the increasing maturity of industrial superconductivity. In an ambitious step beyond present activities, EcoSwing will advance the TRL from 4-5 to 6-7. We are shifting paradigms: Previously, HTS was considered for very big, highly efficient turbines for future markets only. By means of cost-optimization, EcoSwing targets a turbine of great relevance already to the present large-scale wind power market. The design principles of EcoSwing are applicable to markets with a wide range of turbine ratings from 2 MW to 10 MW and beyond.

Despite technological successes in superconductivity, turbine manufacturers and generator suppliers are hesitant to apply HTS into the wind sector, because of real and perceived risks. The environment inside a wind turbine has unique requirements to generators (parasitic loads and moments, vibration, amount of independent hours of operation). Therefore, a demonstration is required.

The consortium represents a full value chain from materials, over components, up to a turbine manufacturer as an end-user providing market pull. It features competent partners on the engineering, the cryogenic, and the power conversion side. Also ground-based testing before turbine deployment, pre-certification activities, and training are included.

EcoSwing can become tangible: The EcoSwing demonstrator will commence operation in 2018 on an existing very modern 3.6 MW wind turbine in Thyborn, Denmark.";13846593,75;10591733,64;H2020-LCE-2014-2;IA;ENVISION ENERGY (DENMARK) APS;DK;"GERMANISCHER LLOYD INDUSTRIAL SERVICES GMBH;SUMITOMO (SHI) CRYOGENICS OF EUROPE LIMITED;UNIVERSITEIT TWENTE;JEUMONT ELECTRIC SAS;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DELTA ENERGY SYSTEMS GMBH;THEVA DUENNSCHICHTTECHNIK GMBH;ECO 5 GMBH";"DE;UK;NL;FR"; 194886;653531;FIVEVB;SIGNED;H2020-EU.3.4.;GV-1-2014;H2020;Five Volt Lithium Ion Batteries with Silicon Anodes produced for Next Generation Electric Vehicles;1/05/2015;30/04/2018;;"The FiveVB project will develop a new cell technology based on innovative materials such as high capacity anodes, high voltage cathodes and stable, safe and environmentally friendly electrolytes. Since main European industry partners representing the value chain from materials supplier to car manufacturer are involved, this program will support and enable the development of a strong and competitive European battery industry. The multidisciplinary project team will also assure not only early technology integration between materials, cells, batteries and application requirements, but also a subsequent industrialization of the developed technology.
With an integrated trans-disciplinary cell development approach we will also realize an early feedback loop from battery and vehicle level to material suppliers and a feed-forward of relevant information to industrial scale cell production. Through an iterative and holistic approach two generations of cell chemistries (anode, cathode, binder and electrolyte) will be evaluated and optimized to improve electrochemical performance of active materials and related new cell technology in terms of energy density, lifetime, safety and costs. Furthermore, we will address early development and validation of test procedures for the reduction of development time from material to cell by e.g. accelerated test procedures. Among other objectives, in particular the lifetime and aging aspects will be addressed in depth in FiveVB, but also input for future European and International standardization will be provided.
Thus, one major result of FiveVB is a hard case prismatic cell in PHEV1 format, developed according to automotive requirements and produced on a representative prototype facility.";5927428,75;5673272,5;H2020-GV-2014;RIA;AVL LIST GMBH;AT;"Robert BOSCH GMBH;ZENTRUM FUR SONNENENERGIE- UND WASSERSTOFF-FORSCHUNG BADEN-WURTTEMBERG;VRIJE UNIVERSITEIT BRUSSEL;3M DEUTSCHLAND GMBH;ARKEMA FRANCE;Kompetenzzentrum - Das Virtuelle Fahrzeug, Forschungsgesellschaft mbH;BAYERISCHE MOTOREN WERKE AKTIENGESELLSCHAFT;UMICORE;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"DE;BE;FR;AT"; 194863;653417;ReCRED;SIGNED;H2020-EU.3.7.;DS-02-2014;H2020;From Real-world Identities to Privacy-preserving and Attribute-based CREDentials for Device-centric Access Control;1/05/2015;30/04/2018;;"ReCREDs ultimate goal is to promote the users personal mobile device to the role of a unified authentication and authorization proxy towards the digital world. ReCRED adopts an incrementally deployable strategy in two complementary directions: extensibility in the type and nature of supported stakeholders and services (from local access control to online service access), as well as flexibility and extensibility in the set of supported authentication and access control techniques; from widely established and traditional ones to emerging authentication and authorization protocols as well as cryptographically advanced attribute-based access control approaches. Simplicity, usability, and users privacy is accomplished by: i) hiding inside the device all the complexity involved in the aggregation and management of multiple digital identifiers and access control attribute credentials, as well as the relevant interaction with the network infrastructure and with identity consolidation services; ii) integrating in the device support for widespread identity management standards and their necessary extensions; and iii) controlling the exposure of user credentials to third party service providers. ReCRED addresses key security and privacy issues such as resilience to device loss, theft and impersonation, via a combination of: i) local user-to-device and remote device-to-service secure authentication mechanisms; ii) multi-factor authentication mechanisms based on behavioral and physiological user signatures not bound to the device; iii) usable identity management and privacy awareness tools; iv) usable tools that offer the ability for complex reasoning of authorization policies through advanced learning techniques. ReCREDs viability will be assessed via four large-scale realistic pilots in real-world operational environments. The pilots will demonstrate the integration of the developed components and their suitability for end-users, so as to show their TRL7 readiness.";6325156;4997242;H2020-DS-2014-1;IA;UNIVERSITY OF PIRAEUS RESEARCH CENTER;EL;"VERIZON NEDERLAND BV;CERTSIGN SRL;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;UPCOM BVBA;DE PRODUCTIZERS BV;STUDIO PROFESSIONALE ASSOCIATON A BAKER & MCKENZIE;TECHNOLOGIKO PANEPISTIMIO KYPROU;WEDIA LIMITED;TELEFONICA INVESTIGACION Y DESARROLLO SA;EXUS SOFTWARE LTD;UNIVERSIDAD CARLOS III DE MADRID";"NL;RO;IT;BE;CY;EL;ES;UK"; 194946;654175;HNSKMAP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High-order Numerical Schemes for Kinetic Models with Applications in Plasma Physics;1/02/2016;31/01/2018;;"In the proposed research, we will devote to the mathematical and numerical analysis of kinetic models. Kinetic theory has wide applications in physical and social sciences, such as plasma physics, semi-conductors, polymers, traffic networking etc.

On the one hand, we want to propose and analyse systematic numerical methods for nonlinear kinetic models which have some challenging difficulties such as physical conservations, asymptotic regimes and stiffness. On the other hand, applications to plasma physics will be investigated, which are mainly high dimensional problems with multi-scale and complex geometries. Moreover collisions between particles for large time scale simulation need to be taken into account.
We would like to develop a class of less dissipative high order Hermite methods together with weighted essentially non-oscillatory (WENO) reconstructions to control spurious numerical oscillations, and high order asymptotic preserving (AP) discontinuous Galerkin (DG) schemes with implicit-explicit (IMEX) time discretizations for multi-scale stiff problems under unresolved meshes. More importantly, these developed numerical methods would satisfy the positivity preserving (PP) principle, such as positive density distribution functions for kinetic descriptions, which is often violated by high order numerical methods with physical meaningless values.

This project will combine the expertise of the Experienced Researcher Dr. Tao Xiong in high order PP flux limiters and high order AP DG-IMEX schemes, and the Host Dr. Francis Filbet in mathematical modellings and numerical tools for kinetic equations. The developed approaches will be translated to the study of turbulent plasma physics such as 4D drift kinetic, 5D gyro-kinetic and 6D kinetic models etc.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE PAUL SABATIER TOULOUSE III;FR;UNIVERSITE CLAUDE BERNARD LYON 1;FR; 194923;654021;OpenMinTeD;SIGNED;H2020-EU.1.4.1.3.;EINFRA-1-2014;H2020;Open Mining INfrastructure for TExt and Data;1/06/2015;31/05/2018;;Recent years witness an upsurge in the quantities of digital research data, offering new insights and opportunities for improved understanding. Text and data mining is emerging as a powerful tool for harnessing the power of structured and unstructured content and data, by analysing them at multiple levels and in several dimensions to discover hidden and new knowledge. However, text mining solutions are not easy to discover and use, nor are they easily combinable by end users. OpenMinTeD aspires to enable the creation of an infrastructure that fosters and facilitates the use of text mining technologies in the scientific publications world, builds on existing text mining tools and platforms, and renders them discoverable and interoperablethrough appropriate registriesand a standards-based interoperability layer, respectively. It supports training of text mining users and developers alike and demonstrates the merits of the approach through several use cases identified by scholars and experts from different scientific areas, ranging from generic scholarly communication to literaturerelated tolife sciences, food and agriculture, and social sciences and humanities. Through its infrastructural activities, OpenMinTeDs vision is tomake operational a virtuous cycle in which a) primary content is accessed through standardised interfaces and access rules b) by well-documented and easily discoverable text mining services that process, analyse, and annotate text c) to identify patterns and extract new meaningful actionable knowledge, which will be used d) for structuring, indexing, and searching content and, in tandem, e) acting as new knowledge useful to draw new relations between content items and firing a new mining cycle. To achieve its goals, OpenMinTeD brings together different stakeholders, content providers and scientific communities, text mining and infrastructure builders, legal experts, data and computing centres, industrial players, and SMEs.;6068072,5;5375535,5;H2020-EINFRA-2014-2;RIA;ATHENA RESEARCH AND INNOVATION CENTER IN INFORMATION COMMUNICATION & KNOWLEDGE TECHNOLOGIES;EL;"AGRO-KNOW IKE;EUROPEAN MOLECULAR BIOLOGY LABORATORY;FRONTIERS MEDIA SA;THE UNIVERSITY OF MANCHESTER;UNIVERSITY OF GLASGOW;THE UNIVERSITY OF STIRLING;Centro Nacional de Investigaciones Oncolgicas;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;STICHTING LIBER;TECHNISCHE UNIVERSITAT DARMSTADT;THE UNIVERSITY OF SHEFFIELD;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;THE OPEN UNIVERSITY;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE;UNIVERSITEIT VAN AMSTERDAM;GESIS - LEIBNIZ INSTITUT FUR SOZIALWISSENSCHAFTEN e.V.";"EL;DE;CH;UK;ES;NL;FR"; 194981;654688;ActiDoC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Active Doping in Colloids;1/04/2015;31/03/2017;;"Great interest has recently been sparked in active soft matter and more specifically mixtures of active with passive systems. These works have shown how passive colloidal particles influenced by activity, give rise to interesting non-equilibrium interactions and microscopic transport effects. However, the effects of mixing diverse biological and synthetic active systems with passive particles are far from understood. Developing on the applicants experience, we propose a combined experimental and simulation physics-based study of the effects of doping active systems in concentrated suspensions of passive particles, while simultaneously looking at the dynamical properties of a single passive particle in a bath of activity. Initially we plan to experimentally examine a well-characterised model active system; platinum coated polystyrene Janus particles in a 2D geometry, mixed with passive particles. Using microscopy and particle tracking, we will study the effects and phase behaviour of active doping on dilute and dense suspensions of particles in a well-controlled setting. Simultaneously we will carry out overdamped dynamical simulations to guide and supplement experimental measurements. Subsequently, we plan to branch out and increase the complexity by expanding to 3D systems and other types of activity. Active doping of concentrated passive suspensions is expected to strongly influence phase and macroscopic behaviours, while doping of dilute suspensions will allow modification of the dynamics of single particles. Therefore, our work will provide fundamental understanding on the workings of activity on passive systems, leading to new insights for macroscopic applications, on processing and design of targeted materials, as well as and lab-on-a-chip applications dealing with microscopic transport and sorting. The candidate will work on cutting edge active systems within the group of Prof. W. Poon, the holder of an ERC Advanced Grant on the physics of active matter.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 194845;653288;OPTEMUS;SIGNED;H2020-EU.3.4.;GV-2-2014;H2020;Optimised Energy Management and Use;1/06/2015;28/02/2019;;"Optimised energy management and use (OPTEMUS) represents an opportunity for overcoming one of the biggest barriers towards large scale adoption of electric and plug-in hybrid cars: range limitation due to limited storage capacity of electric batteries.

The OPTEMUS project proposes to tackle this bottleneck by leveraging low energy consumption and energy harvesting through a holistic vehicle-occupant-centred approach, considering space, cost and complexity requirements. Specifically, OPTEMUS intends to develop a number of innovative core technologies (Integrated thermal management system comprising the compact refrigeration unit and the compact HVAC unit, battery housing and insulation as thermal and electric energy storage, thermal energy management control unit, regenerative shock absorbers) and complementary technologies (localised conditioning, comprising the smart seat with implemented TED and the smart cover panels, PV panels) combined with intelligent controls (eco-driving and eco-routing strategies, predictive cabin preconditioning strategy with min. energy consumption, electric management strategy).

The combined virtual and real-life prototyping and performance assessment in a state of the art, on-the-market A-segment electric vehicle (Fiat 500e) of this package of technologies will allow demonstrating a minimum of 32% of energy consumption reduction for component cooling and 60% for passenger comfort, as well as an additional 15% being available for traction, leading to an increase of the driving range in extreme weather conditions of at least 44 km (38%) in a hot ambient (\35C and 40% rH) and 63 km (70%) in a cold ambient (-10C and 90% rH).";6390633,75;6390633,75;H2020-GV-2014;RIA;Kompetenzzentrum - Das Virtuelle Fahrzeug, Forschungsgesellschaft mbH;AT;"BAX & WILLEMS;ESI SOFTWARE GERMANY GMBH;SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;CENTRO RICERCHE FIAT SCPA;MONDRAGON GOI ESKOLA POLITEKNIKOA JOSE MARIA ARIZMENDIARRIETA S COOP;DENSO AUTOMOTIVE DEUTSCHLAND GMBH;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;ESI GROUP S.A.;SISTEMI SOSPENSIONI SPA;Continental Automotive GmbH;IFP Energies nouvelles;UNIVERSITA DEGLI STUDI DI SALERNO;DENSO Thermal Systems S.p.A.";"ES;DE;IT;FR"; 194930;654101;EntreLab;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Entrepreneurial Laboratory for teachers training. A Capability Approach for Entrepreneurship Education in Vocational education;1/08/2015;31/07/2017;;"The aim of this project is to create a model for continuous teachers training on entrepreneurship education, provide guidelines and best practices on the pedagogies conductive for entrepreneurship education in vocational education. The Entrepreneurial Laboratory will be composed of workshops with the participation of teachers in vocational education and the various stakeholders that will discuss how to implement entrepreneurship education in the specific vocational setting chosen for the research. The focus will be on the pedagogies teachers will establish in order to encourage, facilitate and support their students being entrepreneurial in and outside the school environment.

Within Europe 2020 entrepreneurship is considered particularly important as it can tackle youth joblessness and favour social inclusion. While changing the educational system is not an easy process, steps must urgently be taken to implement short, medium, and long term agendas that a move education in the right direction to match Europe 2020 objectives. The literature on entrepreneurship education and the government documents highlight the need to improve the quality of entrepreneurship education in vocational secondary schools through a switch of the pedagogies (teaching methods and didactics) and the creation of conditions for students to show sense of initiative and entrepreneurship in and outside school.In line with a capability approach the final goal will be increasing students autonomy and ability to make choices.

With this post doctoral research comprising scientific publications plus experience in teaching and supervising students, as well as more entrepreneurial competencies the Experienced Researcher will be ready for associate professorship.";179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 195045;655063;ELiQSIR;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Engineered Light Potentials for Quantum Simulation with Individual-Atom Resolution;1/04/2015;31/03/2017;;"Ultracold quantum gases in optical lattices are a key experimental platform for quantum simulation, at the boundary of atomic physics and condensed matter physics. In that context key models can be implemented to help us understand properties of strongly correlated materials such as high-temperature superconductors, opening the route towards designer materials with tailored quantum properties. The recent development of quantum-gas microscopes allows for the direct observation of the spatial distribution of ultracold atoms in an optical lattice, with single-atom and single-site resolution, shedding a new light on the behaviour of strongly-correlated quantum phases. With the possibility of local spin manipulations, out-of-equilibrium dynamics of the system can be further investigated by perturbing it locally and observing the ensuing evolution.
In order to fully exploit these systems, full control of the light potentials, locally and globally, is highly desirable as it will give experimentalists more degrees of freedom to tailor their experiments. Light patterns can be spatially and dynamically changed by a spatial light modulator and projected at a microscopic scale onto the atoms using a quantum gas microscope. The proposed Marie Sk?odowska-Curie Fellow, Dr. Bruno Peaudecerf, will implement and characterize versatile optical potentials with a spatial light modulator. These will allow for a new generation of experiments with quantum gases in optical lattices, in the context of the quantum-gas microscope experiment of Prof. Stefan Kuhr at the University of Strathclyde. By careful tailoring of the shape and dynamical evolution of the light patterns, we aim at realising novel cooling techniques, bringing the atoms down to unprecedentedly low temperatures. Engineering diffraction-limited patterns, we will address individual atoms and reveal the fascinating properties of the quantum phases obtained.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF STRATHCLYDE;UK;;; 195037;655033;JUNO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Joint Volumetric Reconstruction and Automated Analysis of the Fetal Heart from Cardiovascular Magnetic Resonance Images;16/11/2015;15/11/2017;;"Recent advancements in cardiovascular magnetic resonance (CMR) have finally made possible static and dynamic in-vivo imaging of the fetal heart. This new capability has the potential to provide a fundamental new tool for structural and functional assessment of the fetal cardiovascular system, with groundbreaking clinical consequences. In fact, congenital heart diseases (CHDs) and intrauterine growth restriction (IUGR, which induces cardiovascular remodeling) are among the leading causes of infant mortality worldwide. Fetal CMR imaging may potentially allow more accurate diagnosis of these conditions, and thus improve postnatal outcomes thanks to better in-utero therapy administration, delivery and perinatal intervention planning. Unfortunately, fetal CMR is currently limited to the acquisition of a single slice in time, allowing only qualitative and operator-dependent evaluation of the fetal heart. The JUNO project aims at improving the present capabilities of fetal CMR by tackling its limitations with an image processing approach. The specific goals are (1) development of a method for super resolution volumetric reconstruction of the fetal heart, using image registration techniques applied to a set of single-slice acquisitions; (2) development of automated segmentation methods, based on deformable models and atlases, for the identification of structures such as ventricular contours and main vessels boundaries; (3) extraction of quantitative functional parameters (e.g. stroke volume and ejection fraction) from datasets acquired from healthy, CHDs- and IUGR-affected fetuses, to test the feasibility of objective detection of these conditions. By achieving these goals, JUNO will provide an innovative set of methods allowing for the first time quantitative, noninvasive, functional assessment of the fetal cardiovascular system, and thus address a long standing clinical need for such methodology.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195188;655890;TiFuN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Tiny Functional Au Nanorods: Novel NIR-Photothermal Nanoprobes for Single-Molecule Tracking at Confined Cellular Environment;1/04/2015;31/03/2017;;Photothermal Imaging (PhI) is an absorption detection technique used for the detection of single gold nanoparticles (NPs), which can be a valuable tool to tackle complex cellular activities. In order to study the dynamics of individual proteins in confined regions such as in neural synapses or in cell adhesion sites, small nanoprobes are needed. Gold NPs (~ 5 nm) can be used, however their surface plasmon resonance (SPR) is centered at 530 nm, a spectral domain where absorption of cellular organelles results in a background signal, which limits the sensitivity of PhI. A brilliant way to find the needle in the haystack is the development of a novel nanoprobe having NIR-absorption, smaller size and high specificity. In TiFuN, we will achieve this goal by developing tiny (length/diameter <10 nm/5 nm) gold nanorods (T-rods), an elongated gold NP with tunable SPR in the NIR-window. Different aspect ratio T-rods harvested using Density Gradient Ultrahigh (DGU) centrifugation protocol will be highly promising probes for multicolor labeling and detection of proteins. A dedicated PhI setup based on NIR-laser sources will also be built. Subsequently, the bioconjuagted T-rods and NIR-PhI will be used to study the dynamics of neurotransmitter receptors in synapse and integrin proteins in cell adhesion sites owing to their small core volume, NIR-absorption, exceptional photostability, and non-toxicity. Bioconjugated T-rods will also display the unique property of being easily detected with light and electron microscopy at the single- molecule level, and therefore will be a valuable tool for light/electron correlative microscopy. This highly interdisciplinary project (optics, chemistry and biology) will utilize the fellows expertise in nanochemistry in combination with world-leading expertise of Prof. Lounis group in single-molecule detection and Dr. Choquet institute in neuroscience and cell biology.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 195062;655170;IILSCFLP;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Influence of Ionic Liquid Solvation on the Chemistry of Frustrated Lewis Pairs;1/10/2015;30/09/2017;;Hydrogen (H2) is an important reagent for the chemical industry as well as representing a promising carbon-free fuel source when made from renewable sources. H2 needs to be activated for these applications, generally using rare, expensive and often toxic transition metal catalysts. Metal-free H2 activation has recently been demonstrated using the concept of frustrated Lewis pairs (FLPs) based on main group elements such as phosphorous and boron rather than transition metals. FLPs are somewhat limited in scope due to the highly reactive Lewis acids (LAs) and bases (LBs) required for H2 activation which can lead to side reactions with substrates and solvents. The use of less reactive FLPs is restricted by the H2 activation step. This project addresses this problem by using the unique solvating ability of ionic liquids (ILs) to control the reactivity of FLPs for H2 activation. Many FLPs form ions when they react with H2. To promote H2 activation, it is essential that the reverse reaction (ion recombination to form H2) is prevented. The high ion dissociation power of ILs should prevent the recombination of these ions, leading to more efficient H2 activation. The impact of ILs on H2 activation by FLPs will be investigated in the context of synthesis and fuel cell applications. Successful use of ILs for this purpose would substantially increase the scope of FLP catalysts, reducing the reliance on transition metals thereby decreasing the potential cost and environmental impact of H2 activation processes. This project would represent the first study on the effect of ILs on FLP reactivity and combines the collective expertise of Prof. Welton (ILs) and Dr Ashley (FLPs) at Imperial College (IC) with the applicants background in ILs, kinetics and intermolecular interactions, while providing the applicant with productive collaborative partners and advanced training in catalysis, electrochemistry, IL and FLP chemistry to propel him towards an independent research career.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 194997;654809;HSPACE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High Capacity Space Division Multiplexing Systems;1/01/2016;31/12/2017;;"Our information society relies to an unprecedented extent on broadband communication solutions such as high-speed Internet access, mobile voice and data services, multimedia broadcast systems, etc. In order to fulfil the steadily growing volume and bandwidth demand of those data services while simultaneously reducing the cost per transported information bit, communication systems have been continuously improved in terms of reach and aggregate transport capacity. However, it is now recognised that communication systems are rapidly approaching the fundamental information capacity of current technology, a trend with potential negative impact on the economy and social progress.

HSPACE project targets the development of advanced space division multiplexing (SDM) systems to unlock the capacity of future information systems by enabling the transmission of spatial super-channels over a single fibre. The proposed concept will be implemented using multi-core fibres (MCF) and few-mode fibres (FMFs) as underlying technology platform along with novel digital signal processing (DSP) techniques that minimise the mode/core interference and inter mode/core nonlinearities, keeping the required digital processing at realizable levels. HSPACE offers a continued European leadership in RTD photonics from components to systems, securing the necessary human resources and knowledge to design and produce a new generation of photonic components that support EUs vision for ubiquitous broadband connectivity to promote European social and economic cohesion and prosperity.

The aforementioned challenges require researchers highly trained in a number of relevant disciplines ranging from nonlinear science to high-speed optical communication techniques. This fellowship will provide a gifted early career researcher with the opportunity to train at one of the foremost research centres in optical communication, the Aston Institute of Photonics Technology (AITP).";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 194984;654712;SINHOPSI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Single-Hole Pumping in Silicon;11/01/2016;10/01/2018;;A globally consistent system of measurement units and reference standards is a necessary underpinning feature of most technological, industrial and economic activities. In fact, to perform measurements of physical quantities, record and compare them in a consistent way, systems of units and standards have been historically developed and agreed upon. However, in the last few decades, the ever-increasing need for stability and reliability has determined a shift from standards based on material artefacts or prototypes towards those based on physical phenomena and true constants of nature. The focus of this proposal is the development of a novel quantum technology to generate highly accurate electric currents directly linked to the elementary charge. This could serve as the practical implementation for a quantum-based standard for the SI unit ampere, which is a long-standing goal in electrical metrology. Semiconductor nano-scale charge pumps have been used in the last three decades to generate accurate electric currents by clocking the transport of single electrons with driving oscillators. The main limitation to the fidelity of the charge transfer is ultimately ascribable to the poor spatial confinement of electrons that produces errors during the pumping cycle. In this project silicon-based nanotechnology will be employed to realize and operate the world-first charge pump based on the transfer of single holes rather than electrons. A hole carries the positive equivalent of an elementary charge, but its effective mass can be significantly larger than the electron's. The resulting tightly confined charge carrier wavefunction is expected to provide significant benefits in suppressing pumping errors. The primary objectives will be to develop the underpinning technology to fabricate and operate the first single-hole pump, and experimentally assess its performances in comparison to the well-established electron-based technology.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194994;654740;TRYP-QS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;YAK kinase regulated trypanosome quorum sensing;5/05/2015;4/05/2017;;"African trypanosomes are parasites that cause disease in both humans and livestock throughout sub Saharan Africa, leading to death and hardship in afflicted regions. The disease is spread by blood-feeding tsetse flies and trypanosomes use sophisticated mechanisms to sense their environment in order to optimise their chances of transmission. In particular, whilst in the host bloodstream trypanosomes communicate with one another to monitor their own population density, this determining when they produce specialised transmission stages (so called Stumpy forms). We have recently identified, using a genome-wide RNAi screen, components of the signal transduction pathway that drive this quorum sensing (QS) response. One component seems pivotal in the pathway- a molecule related to the YAK kinase of proteins. In yeasts and slime molds YAK kinase contributes to cell growth arrest in response to extracellular signals including nutrient limitation, whilst in mammals, related molecules of the DYRK family can also act in cellular quiescence. In this proposal we will investigate the function of trypanosome YAK kinase in the parasite's QS response. Specifically, we will investigate the kinase function in vitro and in vivo and dissect its action by following its location and targets. These are likely to differ from the situation in yeasts where YAK relocates to the nucleus and changes mRNA expression; in trypanosomes gene regulation is almost exclusively post transcriptional and likely operates within the cytoplasm. The function, location and interactions of YAK kinase in the QS signalling pathway is expected to provide comprehensive insight into how trypanosome parasites control their development in preparation for transmission, with additional important relevance for related parasites including other kinetoplastids and malaria. A two way benefit, encompassing training and expertise exchange between the researcher and host laboratory, will also be established.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 194869;653454;CREDENTIAL;SIGNED;H2020-EU.3.7.;DS-02-2014;H2020;Secure Cloud Identity Wallet;1/10/2015;30/09/2018;;"With increasing mobility and Internet usage, the demand for digital services increases and has reached critical and high assurance domains like e-Government, e-Health and e-Business. Those domains have high security and privacy requirements and hence will be harnessed with various novel mechanisms for secure access. Approaches for handling the resulting variety of authentication and authorisation mechanisms include the use of digital identity and access management systems (IAM). Like other technologies IAMs follow the trend of using cloud services. This allows abstracting over used resources and enables ubiquitous access to identity data which is stored and processed in the cloud, but also results in an additional degree of complexity for securely operating IAMs.
The goal of CREDENTIAL is to develop, test and showcase innovative cloud based services for storing, managing, and sharing digital identity information and other critical personal data. The security of these services relies on the combination of strong hardware-based multi-factor authentication with end-to-end encryption representing a significant advantage over current password-based authentication schemes. The use of sophisticated proxy cryptography schemes will enable a secure and privacy preserving information sharing network for cloud-based identity information in which even the identity provider cannot access the data in plain-text and hence protect access to identity data. We focus not only on evaluating and applying novel crypto-approaches for IAMs but also on implementing them in an easy-to-use way to motivate secure handling of identity data.
In order to also address security, privacy and trust issues related to the used cloud platforms and services we will investigate assurance and resilience approaches for enhancing underlying cloud services. To empirically evaluate our work and to produce outputs of a high technical readiness we will consider use cases from all three domains mentioned above.";6686660;5978082,5;H2020-DS-2014-1;IA;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;AT;"EUROCLOUD EUROPE ASBL;KLUGHAMMER GMBH;TECHNISCHE UNIVERSITAET GRAZ;LOMBARDIA INFORMATICA SPA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;HELLENIC TELECOMMUNICATIONS ORGANIZATION S.A. - OTE AE (ORGANISMOS TILEPIKOINONION TIS ELLADOS OTE AE);STIFTUNG SECURE INFORMATION AND COMMUNICATION TECHNOLOGIES;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;INFOCERT SPA;ATOS SPAIN SA;KARLSTADS UNIVERSITET";"LU;DE;AT;IT;EL;ES;SE"; 194969;654469;ARTE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Atomic Research for Topological Engineering;1/05/2015;30/04/2017;;Topological quantum computation (TQC) deals with the transformations related to the overall shape (topology) of a quantum trajectory to perform operations on data and go beyond the limitations of quantum computation. It is a revolutionary technique because it will allow quantum operations to be error free and robust while taking advantage of the radically new approaches of quantum computation, which means smaller systems, less energy dissipation, and faster processing. TQC may be naturally implemented using atomic scale systems such as those created by atomic manipulations with scanning probe techniques. The present project is to lay the foundations to make TQC possible. These foundations are the discovery of new exotic states of matter by developing the science and technology of 1-D chains of magnetic moments on superconductors. This implies multi-disciplinary training in single-molecule chemistry, fabrication of superconducting materials, atomic scale magnetic devices and quantum-computation principles. The project is aimed at creating unique career perspectives by learning skills in the atomic engineering of topological superconductors which will grant Dr. Choi a leading independent position. Intersectoral secondments will be used to explore industry interest in developing TQC as a high-value added technology.;158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE;ES;;; 195047;655067;SHARE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Shared Emotions, Group Membership, and Empathy;1/04/2016;31/03/2018;;"What is the relation between empathy, our ability to experience and understand others, and emotional sharing? How do shared emotions and group membership affect or bias empathy? And can groups collectively perform, or be targets of empathy? As the first multi-level approach to the topic, the project SHARE will address this set of questions in relation to one another. It will integrate hitherto unrelated philosophical traditions, research strands and state-of-the-art empirical methods (phenomenology, social ontology, as well as social cognition research and social neuroscience).

SHARE aims not only at a better understanding of the role of emotions in interpersonal and intergroup encounters. The projects distinctively philosophical take will also allow for a systematic re-assessment of empirical data from the social neurosciences, and yield conceptual adjustments that challenge standard literature. Regarding its yet broader socio-cultural impact, the project will contribute to research on group membership induced biases, such as research on racism, intercultural differences in emotional behaviour, or 'emotional dialects', and the 'politics' of affective identity-building.

I will significantly profit from the exceptional scientific resources of the host institution, the Center for Subjectivity Research (CFS) at the University of Copenhagen. CFSs highly interdisciplinary research environment neatly dovetails with the projects working hypotheses. CFSs exceptionally wide research network, as well as the unique expertise of its director and my supervisor, Prof. Dan Zahavi, in both cutting-edge research on phenomenology of sociality, social cognition, and empathy, and in large-scale research management, will guarantee a timely implementation of the project, and promote my professional maturity. Thus, a two-year MSCA-fellowship will re-enforce my status as an independent scholar, ready to assume a permanent a position at a European university.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195173;655814;CheliceLand;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular palaeobiology and comparative genomics of chelicerate terrestrialisation;1/09/2015;31/08/2017;;"Animals have marine origins, with only three phyla including lineages that can complete every phase of their life cycle outside of watersaturated environments. These phyla are the Vertebrata (reptiles, birds and mammals), the Mollusca (land snails and the slugs) and the Arthropoda (e.g. insects, spiders, centipedes). The process through which animals adapted to life on land is referred to as terrestrialisation and it is one of the most fascinating unresolved problems in evolutionary biology. The crossing of the waterland barrier was the most extreme case of adaptation to a new environment in animal history. In fact, the difference between the sea and the subaereal environment is so extreme that astrobiology uses terrestrialisation as an analog to study how life could adapt to a new planet.
Here, I propose a molecular palaeobiological approach where genomic and fossil information will be combined for the first time to study animal terrestrialisation. I will focus on the Chelicerata (spiders, mites, scorpions and their allies), a megadiverse arthropod lineage. Chelicerates represent an ideal model system to investigate the tempo and mode of early animal terrestrialisation, because they were the first animals to become abundant in the terrestrial fossil record. We shall investigate chelicerate relationships, define a timescale of chelicerate evolution, and identify the genomic adaptation that allowed marine chelicerates to adapt to life on land.
This is a blue skies project, however, studying the most extreme case of habitat colonization can help understanding the biology of current invasive species. Chelicerates include pests (e.g. spider mites) and species of biomedical relevance (e.g. ticks). By identifying cheliceratespecific genomic adaptation to life on land, this project will identify potential cheliceratespecific drug targets which may help the development of specific pesticides with low incidence on economically important arthropods, like declining bees.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 194848;653323;C-BORD;SIGNED;H2020-EU.3.7.;BES-09-2014;H2020;effective Container inspection at BORDer control points;1/06/2015;30/11/2018;;"Efficient NII (non-intrusive inspection) of containerised freight is critical to trade and society. Freight containers are potential means for smuggling (e.g. tobacco), illegal immigration, trafficking of drugs, mis-declared goods and dangerous illicit substances, including explosives, nuclear material, chemical and biological warfare agents and radioactively contaminated goods. One inspection NII technology cannot cope with all these targets.
The C-BORD Toolbox and Framework will address all these targets and enable customs to deploy comprehensive cost-effective container NII solutions to potentially protect all EU sea- and land-borders, satisfying a large range of container NII needs.
The C-BORD Toolbox will include 5 complementary innovative detection technologies: delivering improved X-rays, Target Neutron Interrogation, Photofission, Sniffing and Passive Detection. User interfaces and data will be integrated to optimise effectiveness and efficiency of end-users and systems.
The C-BORD Framework will help customs analyse their needs, design integrated solutions, and optimise the container inspection chain; it will address detection levels, false alarm levels, throughput, health & safety, logistics and cost & benefits.
C-BORD will increase the probability of finding illicit or dangerous content with at least equal throughput of containers per time unit, reduce the need for costly, time-consuming and dangerous manual container inspections by customs officials, and in case a container is opened, increase the probability of finding illicit materials. C-BORD involves stakeholders from 8 EU countries, as partners (5) and advisory group members (3). On 3 custom sites integrated solutions will be trialled, respectively addressing the needs of big seaports, small seaports and mobile land-borders. To optimise sustainable impact, C-BORD will actively engage with a large community, will support policy implementation, evolution and start early exploitation planning.";11826452,5;11826452,5;H2020-BES-2014;RIA;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;"ECOLE NORMALE SUPERIEURE;OSLO CENTER FOR SCIENCE IN SOCIETY;THE UNIVERSITY OF MANCHESTER;UNIVERSITA DEGLI STUDI DI PADOVA;SYMETRICA SECURITY LTD;COSTRUZIONI APPARECCHIATURE ELETTRONICHE NUCLEARI C.A.E.N. SPA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;CHAMBRE DE COMMERCE ET D'INDUSTRIE DE REGION PARIS ILE-DE-FRANCE;AGENZIA DELLE DOGANE;ARTTIC;NARODOWE CENTRUM BADAN JADROWYCH;IZBA CELNA W GDYNI;NEMZETI ADO-ES VAMHIVATAL;SMITHS HEIMANN SAS;Hochschule Bonn-Rhein-Sieg;MAGYAR TUDOMANYOS AKADEMIA ENERGIATUDOMANYI KUTATOKOZPONT;MINISTERIE VAN FINANCIEN DIRECTORAAT GENERAAL BELASTINGDIENST;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"FR;NO;UK;IT;DE;PL;HU;NL;BE"; 194979;654615;EVOPRIMPOL;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Artificial evolution of a novel multifunctional human polymerase;1/05/2015;30/04/2017;;"The product of the human gene ccdc111, PrimPol, has been recently identified and characterized by the group of Professor Luis Blanco (CBMSO, Madrid, Spain). This protein is capable of performing both priming and polymerase activities in human cells, contributing to DNA integrity and maintenance during its replication. As an enzyme involved in tolerance to DNA damage, its malfunction gives rise to human diseases. Thus, it might become a target for cancer therapy. In order to exploit the benefits derived from knowledge of PrimPol, a deeper structure-function study must be done. These studies can not be accomplished using standard site-directed mutagenesis protocols and further characterization due to variety activities that this protein displays, the novelty of its discovery and the absence of a solved crystal structure. Thus, EVOPRIMPOL will be a novel, fast and reliable approach to study the role of critical amino acids involved in the different activities shown by the enzyme. This approach is based on the in vitro directed evolution of human gene ccdc111, but unlike other directed studies performed in polymerases, where genes are mutated randomly, in EVOPRIMPOL we will use a new rational design to select those residues that will be randomised; selecting them after the phylogenetic study of all members of the protein superfamily containing PrimPols as well as by homology sequence studies using different DNA polymerases and primases from other superfamilies. Chosen residues will be randomised following an iterative mutagenesis scheme, where evolved variants are subjected to new rounds of mutagenesis mimicking the natural evolution. Thus, improved PrimPols will be obtained with better catalytic properties. Biochemical study of these variants will provide us information about the role of critical residues in the control and regulation of the PrimPol activities, which might be used to generate PrimPols variants with potential biotechnological uses.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 195022;654942;COGNAC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Readdressing Convective-Surface Interaction in Global Climate Models;1/10/2015;30/09/2017;;"A large part of our knowledge on climate change is provided by the usage of coupled atmospheric-ocean Global Climate Models (GCMs), which produce numerical simulations of the Earths climate system for both the present and the future. However, state-of-the-art GCMs show considerable systematic errors: they are limited by low spatial resolutions and by the problematic representation of many physical processes. In particular, one of the largest sources of uncertainty is associated with the coupling between the atmospheric circulation and the water cycle.
COGNAC is conceived as a fundamental theoretical project framed in this context. It aims at readdressing the representation of moist convection, clouds and precipitation and their interaction with the surface and the soil in GCMs. A recently developed theoretical framework capable of treating in a unified way the soil, the Planetary Boundary Layer (PBL), clouds, and both shallow and deep convection will be used. Such model - the Probabilistic Plume Model, PPM - is capable to represent the whole atmospheric column (from the PBL to the tropopause) with results comparable to Large Eddies Simulations and with a minor numerical cost. COGNAC aims at improving and refining the PPM and integrating it into two models, the LMDz GCM and the EC-Earth GCM, in the form a new unified parameterization. First evaluation will be carried out on Single Column Models, and hence extended to the full 3D case. Once operational, these new GCM configurations will provide a powerful tool to study complex interactions among surface, PBL and moist convection, as the ones occurring in the Sahel, the Amazon Rainforest or the Mediterranean region. These advancements will have notable potential for improving the representation, the forecast and the evaluation of the future changes of large-impact hydro-meteorological events.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194931;654109;ACTRIS-2;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;Aerosols, Clouds, and Trace gases Research InfraStructure;1/05/2015;30/04/2019;;"ACTRIS-2 addresses the scope of integrating state-of-the-art European ground-based stations for long term observations of aerosols, clouds and short lived gases capitalizing work of FP7-ACTRIS. ACTRIS-2 aims to achieve the construction of a user-oriented RI, unique in the EU-RI landscape.
ACTRIS-2 provides 4-D integrated high-quality data from near-surface to high altitude (vertical profiles and total-column), relevant to climate and air-quality research. ACTRIS-2 develops and implements, in a large network of stations in Europe and beyond, observational protocols that permit harmonization of collected data and their dissemination. ACTRIS-2 offers networking expertise, upgraded calibration services, training of users, trans-national access to observatories and calibration facilities, virtual access to high-quality data products. Through joint research activities, ACTRIS-2 develops new integration tools that will produce scientific or technical progresses reusable in infrastructures, thus shaping future observation strategies.
Innovation in instrumentation is one of the fundamental building blocks of ACTRIS-2. Associated partnership with SMEs stimulates development of joint-ventures addressing new technologies for use in atmospheric observations.
Target user-groups in ACTRIS-2 comprise a wide range of communities worldwide. End-users are institutions involved in climate and air quality research, space agencies, industries, air quality agencies.
ACTRIS-2 will improve systematic and timely collection, processing and distribution of data and results for use in modelling, in particular towards implementation of atmospheric and climate services. ACTRIS-2 invests substantial efforts to ensure long-term sustainability beyond the term of the project by positioning the project in both the GEO and the on-going ESFRI contexts, and by developing synergies with national initiatives.";10126484,54;9541194,51;H2020-INFRAIA-2014-2015;RIA;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;"LEIBNIZ INSTITUT FUER TROPOSPHAERENFORSCHUNG e.V.;INSTITUTE OF NUCLEAR RESEARCH AND NUCLEAR ENERGY - BULGARIAN ACADEMY OF SCIENCES;METEOROLOGISK INSTITUTT;HELSINGIN YLIOPISTO;CESKY HYDROMETEOROLOGICKY USTAV;UNIVERSIDAD DE VALLADOLID;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ILMATIETEEN LAITOS;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE SCIENZE FISICHE DELLA MATERIA;NATIONAL UNIVERSITY OF IRELAND, GALWAY;UNIVERSITY OF LEEDS;DEUTSCHER WETTERDIENST;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;NATIONAL INSTITUTE OF RESEARCH AND DEVELOPMENT FOR OPTOELECTRONICS;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;Instytut Geofizyki Polskiej Akademii Nauk;NORSK INSTITUTT FOR LUFTFORSKNING;EUROPEAN CENTRE FOR MEDIUM-RANGE WEATHER FORECASTS;PAUL SCHERRER INSTITUT;NATIONAL OBSERVATORY OF ATHENS;LUNDS UNIVERSITET;THE CYPRUS INSTITUTE;RHEINISCHES INSTITUT FUER UMWELT-FORSCHUNG AN DER UNIVERSITAET ZU KOELN E.V.;EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT;B.I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus;KONINKLIJK NEDERLANDS METEOROLOGISCH INSTITUUT-KNMI;PANNON EGYETEM;UNIVERSIDAD DE GRANADA;NATURAL ENVIRONMENT RESEARCH COUNCIL;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"DE;BG;NO;FI;CZ;ES;IT;IE;UK;RO;FR;PL;CH;EL;SE;CY;BY;NL;HU;BE"; 195158;655701;LANTERN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Light-Atom Interactions in Nanophotonic Structures;1/04/2016;31/03/2019;;In recent years, tremendous progress has been made to interface cold atoms with nano-photonic systems, with the motivation of scaling down and transferring ideas from macroscopic platforms, such as cavity QED in Fabry-Perot cavities. However, little attention has been devoted to identifying completely new paradigms for light-matter interactions, which take full advantage of the ability to control the dimensionality and dispersion of light in nanoscale optical structures. Within this context, LANTERN makes an ambitious attempt to theoretically propose new techniques to manipulate atom-photon interactions, to design realistic photonic crystal structures that are simultaneously capable of trapping atoms and realizing the desired physical phenomena, and to help guide state-of-the-art experiments in the field. The fellow will show how such structures can be used to induce strong and tunable long-range interactions between atoms, and to realize strong optical nonlinearities at the single-photon level that do not depend on the saturation of an atom. These approaches are expected to overcome major bottlenecks faced by current experiments to use atoms in quantum information processing and quantum simulation. The multidisciplinary perspective of this action will advance the state of the art in quantum optics, nanophotonics and atomic physics, and will lead to fruitful synergies between theoretical and experimental groups. During the outgoing phase of the grant, Ana Asenjo will join the Quantum Optics group lead by Prof. Kimble at Caltech, in the USA. In the return phase, she will team up with the Theoretical Quantum-Nano Photonics group lead by Prof. Chang at ICFO, in Spain.;257191,2;257191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 194915;653982;GREST;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-1-2014;H2020;Getting Ready for EST;1/06/2015;31/05/2018;;"The present project is intended to take the European Solar Telescope (EST) to the next level of development by undertaking crucial activities to improve the performance of current state-of-the-art instrumentation. Legal, industrial and socio-economic issues will also be addressed, as key questions for the attainment of EST. The particular developments and strategic tasks proposed here can be summarised in the following specific objectives:
(i) Boosting new generation detectors, with the development of two prototype sensors, one for large-format imaging and a the other for high-precision polarimetry, the evaluation of an existing large format wavefront sensing camera is also addressed;
(ii) Development of a capacitance-stabilised Fabry-Perot prototype for a high quality control of the parallelism of the etalon plates;
(iii) new techniques for 2D solar spectro-polarimetry; with integral field units based on multi-slit image slicers or a microlens-fed spectrograph;
(iv) development of large format liquid-crystal modulators, required for the large-format sensors that will be needed for the new generation large aperture telescopes ;
(v) evaluation of the performance of the EST-MCAO deformable mirrors to improve the design and performance of this system; and
(vi) strategic work to covering industrial, financial and legal issues related the future construction and operation of EST. The following issues will be addressed:
Elaboration of a census of the European solar physics community
Analysis of the technological expertise of European companies in the different countries and their potential expertise related with the construction needs of EST
Revision and update of the construction budget of EST
Stimulation of a discussion of all these aspects within the consortium EAST
With all these elements in hand, the project will be in the condition to present a definite proposal for detailed design, construction, managing and operation of EST.";3956730;2977273;H2020-INFRADEV-1-2014-1;RIA;INSTITUTO DE ASTROFISICA DE CANARIAS;ES;"AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ANDOR TECHNOLOGY LIMITED;ARCOPTIX SA;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;INSTITUTO NACIONAL DE TECNICA AEROESPACIAL ESTEBAN TERRADAS;THE QUEEN'S UNIVERSITY OF BELFAST;CONSIGLIO NAZIONALE DELLE RICERCHE;ISTITUTO NAZIONALE DI ASTROFISICA;A.D.S. INTERNATIONAL SRL;UNIVERSITY COLLEGE LONDON;STOCKHOLMS UNIVERSITET;UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA";"ES;UK;CH;DE;IT;SE"; 194833;653188;GLASS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Glass, Faience and Food in Late Bronze Age Societies: An Analysis of the Socio-Economics of Urban Industries in Egyptian and Mesopotamian settlements;1/10/2015;30/09/2017;;This project aims to establish an in-depth understanding of the administration and control of high-temperature industries on an urban level and the socio-economic relationship between the elite and the non-elite members of society in Late Bronze Age (LBA) Egypt and Mesopotamia (c. 1650-1050 BC). It has been recognised in the past that within the urban settlements of Egypt and Mesopotamia the production of basic faience- and glass-objects frequently occurred in the same urban domestic context as that of foodstuffs, using the same tools and firing structures. This analysis will particularly highlight how elite control influenced these domestic industries in an urban setting, and to what extent this influenced the role of the members of a non-elite population and the urban infrastructure. The project will examine the following aspects: (1) The spatial analysis of the relationship between the production of glass artefacts and that of faience goods and foodstuffs using Geographical Information Systems (GIS) technology: Concentrating on the New Kingdom Egyptian settlement of Amarna, domestic and administrative archaeological contexts containing a combination of glass-working, faience manufacture and food production will be identified, documented and analysed in detail. (2) The organisation of workshops and areas of industrial activity throughout the urban sites and their infrastructures, within both LBA Egypt and Mesopotamia: This will also be done using GIS, but will also include published and unpublished materials and contemporary textual sources providing knowledge about urban workshops and domestic industrial settings. (3) A comparison of industrial activities within ancient Egyptian settlements and those taking place in contemporary ancient Mesopotamian settlement and palace sites. (4) Export and trade facilities and networks, in order to demonstrate how the produce of these industries was consumed, transported and, possibly, traded.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FREIE UNIVERSITAET BERLIN;DE;;; 194854;653355;FORENSOR;SIGNED;H2020-EU.3.7.;FCT-05-2014;H2020;FOREnsic evidence gathering autonomous seNSOR;1/09/2015;31/08/2018;;"Covert evidence gathering has not seen major changes in decades. Law enforcement Agencies (LEAs) are still using conventional, manpower based techniques to gather forensic evidence. Concealed surveillance devices can provide irrefutable evidences, but current video surveillance systems are usually bulky and complicated, are often used as simple video recorders, and require complex, expensive infrastructure to supply power, bandwidth, storage and illumination.
Recent years have seen significant advances in the surveillance industry, but these were rarely targeted to forensic applications. The imaging community is fixated on cameras for mobile phones, where the figures of merit are resolution, image quality, and low profile. A mobile phone with its camera on would consume its battery in under two hours. Industrial surveillance cameras are even more power hungry, while intelligent algorithms such as face detection often require extremely high processing power, such as backend server farms, and are not available in conventional surveillance systems.

Here we propose to develop and validate a novel, ultra-low-power, intelligent, miniaturised, low-cost, wireless, autonomous sensor (FORENSOR) for evidence gathering. Its ultra-sensitive camera and built-in intelligence will allow it to operate at remote locations, automatically identify pre-defined criminal events, and alert LEAs in real time while providing and storing the relevant video, location and timing evidence. FORENSOR will be able to operate for up to two months with no additional infrastructure. It will be manageable remotely, preserve the availability and the integrity of the collected evidence, and comply with all legal and ethical standards, in particular those related to privacy and personal data protection. The combination of built-in intelligence with ultra-low power consumption could help LEAs take the next step in fighting severe crimes.";4914262,5;4043546,25;H2020-FCT-2014;IA;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;EL;"VRIJE UNIVERSITEIT BRUSSEL;ALMAVIVA - THE ITALIAN INNOVATION COMPANY SPA;SYNELIXIS LYSEIS PLIROFORIKIS AUTOMATISMOU & TILEPIKOINONION MONOPROSOPI EPE;EMZA VISUAL SENSE LTD;AYUNTAMIENTO DE VALENCIA;Ministrio da Justia;STMICROELECTRONICS SRL;JCP-CONNECT;FONDAZIONE BRUNO KESSLER;VISIONWARE-SISTEMAS DE INFORMACAO SA";"BE;IT;EL;IL;ES;PT;FR"; 194954;654339;QUTEMAG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum-Enhanced Optical Magnetometers;1/04/2016;31/03/2018;;"During the past ten years tools from Quantum Optics such as quantum-non-demolition (QND) measurements and squeezed light have emerged as powerful means to control quantum states of matter, perform ultra-sensitive measurements, and enhance physical systems beyond their classical limits. At the same time optical magnetometers developed within the discipline of Atomic Physics have established themselves as the most sensitive detectors of magnetic fields with current performance reaching the limits of classical techniques. To date, in a proof-of-principle way, QND and squeezed light have been used to improve the performance of these instruments independently but not within the same device. Their simultaneous use in a best-in-class magnetometer remains an open challenge. To achieve this ambitious research goal we propose to combine QND and squeezed light resources to magnetometry at large atomic densities, i.e. in a regime where spin-exchange collisions dominate the spin dynamics. This novel approach will be key in enhancing current technology most suitable to address challenges in the real world.
QUTEMAG combines a wealth of expertise in Optical Magnetometry and Quantum Optics. The Experienced Researcher Dr. Ricardo Jimnez Martnez, is an expert in Optical Magnetometry. The Supervisor Professor Morgan Mitchell is a leader in QND methods and quantum light pioneering the techniques that will enable the quantum-enhancement of optical magnetometers in the proposed work. The goal of the training program of the researcher is to develop new research competencies in quantum optics and managing skills of interdisciplinary research in Quantum Optics and Metrology, Atomic Physics and Photonics.The Host Institution, ICFO-The Institute of Photonic Sciences in Spain, provides a world-class research and training environment to achieve the research and training goals of QUTEMAG during the 24-month span of the project.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;;; 194966;654416;SESAME NET;SIGNED;H2020-EU.1.4.1.3.;EINFRA-6-2014;H2020;Supercomputing Expertise for SmAll and Medium Enterprise Network;1/06/2015;31/05/2017;;Network of HPC Competence Centres for SMEs;1998363,75;1998363,75;H2020-EINFRA-2014-2;CSA;ARCTUR RACUNALNISKI INZENIRING DOO;SI;"VILNIAUS UNIVERSITETAS;FONDS VOOR WETENSCHAPPELIJK ONDERZOEK-VLAANDEREN;UNIVERSITATEA DE VEST DIN TIMISOARA;HERCULESSTICHTING;NATIONAL UNIVERSITY OF IRELAND, GALWAY;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK;YOTTA ADVANCED COMPUTING DOO ZA ISTRAZIVANJE I USLUGE;RUDER BOSKOVIC INSTITUTE;INSTITUTE OF INFORMATION AND COMMUNICATION TECHNOLOGIES;HIGH PERFORMANCE COMPUTING WALES;FUNDACION PUBLICA GALLEGA CENTRO TECNOLOGICO DE SUPERCOMPUTACION DE GALICIA;MEO-SERVICOS DE COMUNICACOES E MULTIMEDIA SA;BANGOR UNIVERSITY;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE;VYSOKA SKOLA BANSKA - TECHNICKA UNIVERZITA OSTRAVA";"LT;BE;RO;IE;DE;PL;HR;BG;UK;ES;PT;EL;CZ"; 195008;654861;DAM-NET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Dam-nations? A study on dams, nation-building and transboundary water relations through case-studies from Ethiopia and Tajikistan;1/09/2015;31/08/2017;;"The aim of DAM-NET is to enable the Future Fellow (FF) to carry out a state-of the art research project, investigating how ruling elites can use the symbolic value of a large hydraulic infrastructure to construct and disseminate their particular idea of the nation and legitimize their hold on power. The study will expand on the largely unexplored link between water and social power, bringing new insights into the analysis of transboundary water relations and on the role that discourse and nationalism play in water politics. Throughout a varied set of activities, the project will allow transfer of knowledge and the training of the FF, thus improving his employability and career perspectives.
Interdisciplinary in nature, DAM-NET will draw upon insights from International Relations (IR), nationalism studies and political geography to create a framework for the analysis of the politics of mega-dams. Specifically, two case studies the Grand Ethiopian Renaissance Dam (GERD) in Ethiopia and the Rogun Dam (RD) in Tajikistan will serve as a platform to analyse the discursive constructions surrounding mega-dams, and to map and unpack stakeholder and elite networks associated with the water sector in both countries.
Besides their scholarly relevance, the research findings will provide important policy insights for a better understanding of the new boom in global dam building, and for the explanation of seemingly irreparable regional conflicts triggered by the construction of extremely costly megaprojects.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 194964;654387;RICAS2020;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-1-2014;H2020;Design Study for the European Underground Research Infra-structure related to Advanced Adiabatic Compressed Air Energy Storage;1/06/2015;31/05/2018;;"Challenges like climate change, economic, social and sustainable development as well as security are closely linked to the energy supply of European societies. In 2009, the European Union adopted a climate and energy package including that at least 20% of EU gross final energy consumption have to come from renewable energy sources until 2020. The challenge of RICAS2020 is given by intermittent renewable energy sources which require increased energy storage to time shift this energy to meet daily demand. As a consequence, the demand for technologies for providing and storing energy is consequently increasing.
The RICAS2020 Design Study for the European Underground Research Infrastructure related to Advanced Adiabatic Compressed Air Energy Storage (AA-CAES) will provide concepts to set-up a research infrastructure dedicated to underground storage of very high amounts of green energy. The big advantage of the new concepts will be that the underground energy storage can be performed independently from the encountered geological conditions and also at all places where high energy demand exists.
AA-CAES collects the heat produced by compression and returns it to the air when the air is expanded to generate power and thus delivers higher efficiencies via a zero-carbon process. The Design Study RICAS2020 will provide concepts on the key criteria and focus on technical, legal, institutional and financial requirements of such a research facility and will be open for the whole European Research Area, especially for all research fields close to Energy Providers and Suppliers.
RICAS2020 will be located as an extension to the research infrastructure Research@ZaB in Eisenerz, Austria, which is financed by the Austrian government and designed as a European Underground Research-, Training- and Test-facility focussing on underground mobility including tunnels and subways. Synergies between RICAS2020 and Research@ZaB will be given in all underground technologies.";1373637,5;939137,5;H2020-INFRADEV-1-2014-1;CSA;MONTANUNIVERSITAT LEOBEN;AT;"HBI HAERTER GMBH;BAYERISCHES LASERZENTRUM;STIFTELSEN SINTEF;GENERAL ELECTRIC (SWITZERLAND) GMBH;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;ACONDICIONAMIENTO TARRASENSE ASSOCIACION";"DE;NO;CH;ES"; 194911;653950;URBANCO2FLUX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Quantifying the impact of the urban biosphere on the net flux of CO2 from cities into the atmosphere.;7/09/2015;6/09/2018;;"Due to the offsetting effect of the urban biosphere resulting from the photosynthetic uptake of CO2 by plants that are often well watered and fertilized, the precise impact of urban emissions on the global burden of GHGs is challenging to quantify. Green-space initiatives that increase the vegetative coverage of the landscape, and therefore the productivity of the urban ecosystem for sequestration of CO2 are often proposed as GHG reducing strategies, despite there being very little quantitative evidence for the effectiveness or efficiency of such strategies. Uncertainty in the time scales for respiration of carbon previously taken up through photosynthesis obscures the picture even further. Meanwhile, as the modern urban landscape is continually evolving, with green spaces and parks becoming a more integral component and with suburbs expanding outward from city centers into previously rural, agricultural, and natural areas, it is apparent that we lack the scientific understanding of how best to implement planning strategies that minimize the impact of such changes on climate.
I have expertise in urban metabolism and quantifying carbon footprint at city level, however I lack the scientific knowledge required to understand and quantify the impact of the (urban) biosphere on the net flux of CO2 from cities into the atmosphere. UC Merced, presently leading a 4-yr NSF project in atmospheric modeling of COS to understand carbon cycle processes in urban ecosystems, provides the ideal training ground for me to gain the skills necessary to reach excellence in this multi-disciplinary effort to making our cities more sustainable. The project aims to answer the following questions:
What is the global impact of urban/suburban ecosystems on atmospheric CO2?
How will future shifts in land-use types and management practices in densely populated areas influence surface atmosphere fluxes of CO2?";257191,2;257191,2;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITAT AUTONOMA DE BARCELONA;ES;;; 194916;653985;IMP3rove for Future;SIGNED;H2020-EU.2.3.;INNOSUP;H2020;Adapting and maintaining the innovation management assessment tools and support Enhancing the innovation management capacity of SMEs;1/10/2014;31/12/2019;;"'IMP?rove for Future will build on the proven and well-tested innovation management support services developed in the previous IMP?rove projects initiated by the European Commission to help mainly the Enterprise Europe Network (EEN) using IMP?rove services for 'enhancing the innovation management capacity of SMEs'. Furthermore, IMP?rove support services and training programs will be developed to address up-coming needs of SMEs and the support providers. In seven work packages an operational and capacity building / training environment will be created: Innovation management training programs will be further developed and implemented for EEN and other innovation support providers. Coaching of EEN partners in rendering effective innovation management assessments based on the IMP?rove benchmarking tools, and new benchmarking features will be developed. Actions in regions and Member States to develop better programs to enhance innovation management capacity at SMEs will be supported with new IMP?rove products and services. Within this project also the European and international standardisation activities in innovation management will be supported.
The project will actively involve the key stakeholders in shaping the training program, the new features of the IMP?rove platform and in delivering the IMP?rove support services in the most effective manner.
The expected results of this 28 months project are more than 400 EEN members rendering effective innovation management benchmarking services and support to SMEs, more than 4,000 SMEs that have benefited from the IMP?rove services and have been put on the growth track and about 10 other actors in regions and Member States developed better programs for innovation management capacity building of SMEs. They all can rely on the IMP?rove methodology and assessment tools and services compliant with international standards in innovation management.'";2330022;2330022;H2020-Adhoc-2014-20;CSA;IMP'ROVE - EUROPEAN INNOVATION MANAGEMENT ACADEMY EWIV;DE;;; 195030;654990;CLOPRESS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Renal Chloride Chanels and Blood Pressure Regulation;1/05/2015;30/04/2017;;Hypertension, or elevated arterial blood pressure, is a significant global health concern. A major cause of hypertension is the abnormality in salt (NaCl) handling in distal nephron segments within kidney. Although there has been long a debate with regard to the relative importance of Na\ vs. Cl- in inducing salt-sensitive hypertension, previous research demonstrated that excess intake of Cl- could lead to severe salt-sensitive hypertension. Thus, better understanding on molecular mechanisms of renal Cl- handling would provide useful insights in treatment of hypertension. Previous studies largely focused on the identification and regulation of apically expressed Cl- transporters, including Na\-Cl- cotransporter, Na\-K\-2Cl- cotransporter (NKCC1/NKCC2) and pendrin, but mechanisms and regulation of Cl- transporters on basolateral membranes (i.e. an exit of Cl- into the interstitial space) remains poorly described. Thus, the current proposal will investigate the physiological role of basolateral Cl- channel distributed in distal nephron, specifically ClC-kb. Using a transgenic ClC-kb knockout line of mice, I propose to investigate the physiological role of this channel within isolated tubule and at the whole animal level. In addition, ClC-kb channel is known to interact with a functional ?-subunit, barttin, and this interaction could affect Cl- conductance. I propose to investigate the molecular mechanisms by which barttin can affect ClC-kb-mediated chloride transport. The proposed studies will shed new insights into the molecular mechanisms of Cl- reabsorption in distal nephron, and could provide a basis for novel approach in treatment of hypertension.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 195143;655623;RncRNAA;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Functions of non-coding RNAs in protein synthesis and homeostasis during aging;1/04/2015;31/03/2017;;"Because old age is the largest risk factor for many human diseases, it is one of the key challenges of our time to find ways to increase healthy lifespan and reduce the loss of health in later life. Inhibition of protein synthesis is capable of extending the lifespan of a number of organisms and has been shown to ameliorate symptoms in models of several age related diseases.

Recent studies have shown that non-coding (nc) RNAs frequently interact with translating ribosomes, although little is known about their function there. In previous work, I discovered a ribosome-bound ncRNA to be required for both the inhibition of translation and the increase in lifespan seen in insulin signaling (IIS) mutant worms. However, due to a nematode-specific RNA trans-splicing mechanism, affecting post-transcriptional gene regulation, the relevance of these results to others organisms remains unclear.

Given the crucial role protein synthesis plays in lifespan determination and the unexplored functions of ncRNAs in this process, I propose to systematically investigate the role of ncRNAs in translation and longevity. My goal is to identify ncRNAs that interact with ribosomes that have an effect on proteostasis or post-transcriptional gene regulation and consequently on lifespan extension and understanding their function.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 195032;655016;EPINET;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Detection of brain patterns for the characterisation of epileptic networks;5/10/2015;4/10/2017;;This project will bring in a research fellow with significant experience in the development and application of signal processing tools applied to electromagnetic brain signal, to work with a group carrying out leading research in epilepsy and in the development of non-invasive tests to localise brain function in patients with drug-resistant epilepsy. EPINET research aims at developing and validating innovative methods to localise and characterise non-invasively functional properties of the epileptogenic zone (EZ), i.e. the area responsible for the generation of epileptic seizures. The candidate, L. Quitadamo (LQ), will bring to the team expertise in the classification of biological signal and computer programming developed through collaborations with world-leading teams involved in brain-computer interface (BCI) research, complementing the expertise of the host research group in non-invasive mapping of brain function. Furthermore, she will benefit from expert training in the analysis of neuroimaging and neurophysiological tests (Magnetoencephalography (MEG), High Resolution EEG (HR-EEG), spike-activated fMRI and Intracranial EEG). The benefit will be two-fold: The candidate will extend her expertise in signal processing to the clinical assessment of patients with drug-resistant epilepsy, developing new and complementary skills applied to specific clinical applications, which will enable her to reach a position of maturity and professional independence. The host group will have access to new methods of classification of bioelectrical signal and develop analysis tools that will be made available in the public domain together with a repository of multimodal electromagnetic signal obtained in the presurgical assessment of patients with epilepsy.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ASTON UNIVERSITY;UK;;; 194818;652856;CLEANLIB;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cleansing the Library: the Expurgatory Censorship of Books in Europe (Science and Humanities, 16th-18th cent.);1/01/2016;31/12/2017;;"This research project presents the issues related to the Inquisition censorship over books, to cleanse them of danger and impurities during the 16th-18th centuries in Europe. It aims at answering the question of what was actually done, how and why; to assess the effectiveness and tell the history of early modern expurgation, or microcensorship, of the contents, and the connections between the tools used by the control system, the indexes of prohibition and expurgation; to edit the latter, printed in the 17th century. Given the vastness of the bibliographical field, the framework of the research focuses on two disciplines: Science and Humanities. The testing ground of the specific methodological introduction and rare books exploration produced objective results and certainties about its accuracy and efficiency. Microcensorship studies can be initiated as a critical contribution to the general history of censorship, with a large historical and geographical perspective.
The IEF two year-training project is completed in a research centre in Barcelona. Spain was the dominant country in the early modern expurgation technology; this strategic city is located at the critical crossroads of censoring and correcting cultures using the same means. A systematic exploration of the local and national libraries and archives will provide information on an unprecedented scale. Moreover, censorship studies represent an important part of Spanish research. Thanks to its newness, this project can potentially intensify international cooperation, intra- and extra-European cooperation, to enrich doctoral training. The matter intrinsically interconnects disciplines, cultures and societies, and is related to non academic activities. Being a large-scale undertaking in early stages, the aims of this field of research are to be institutionalized, expanded and internationally adopted. CleanLib meets the demand for knowledge sharing and dissemination, and is relevant to the H2020 Program.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 194982;654691;RESCUE THE HEART;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts;1/04/2016;31/03/2018;;This project is designed to use the latest advances in molecular biology and neuroscience to determine the role played by the nervous mechanisms in the development of cardiovascular pathology. The project spans across distinct research fields of myocardial ischaemia/reperfusion injury, innate cardioprotective mechanisms and fundamental neuroscience and includes newly developed transgenic mice models and latest advances in viral gene transfer technology, pharmaco- and optogenetics for selective manipulation of parasympathetic or sympathetic efferent outflows to the heart. These novel genetic models offer unprecedented resolution and specificity and will be used to determine the role played by the autonomic nervous system in modulation of the myocardial ischaemia/reperfusion injury and progression of chronic heart failure. Another important part of this study will determine the involvement of neural pathways in powerful innate mechanisms of cardioprotection underlying the (pre)conditioning phenomena. The results of the proposed experiments are expected to have an instant translational potential and may lead to the development of novel therapeutic strategies which recruit innate neural mechanisms of cardioprotection to limit myocardial injury and improve quality of life of individuals suffering from heart disease. RESCUE THE HEART project includes an intense program of research and training to be undertaken by the experienced researcher and will ultimately promote effective transfer of research expertise, new technologies and research philosophy across wider European research base.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 194839;653240;STRESSAGED;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Molecular Mechanisms Linking Psychological Stress and Ageing-Related Disease;1/05/2015;30/04/2017;;Ageing-related diseases are the leading causes of morbidity and mortality. A ubiquitous and potentially preventable factor predisposing to their development is psychological stress, but the molecular mechanisms underlying this relation are largely unknown. This knowledge gap is addressed by the proposed project, which examines epigenetic modifications and, in particular, DNA methylation changes as molecular signatures that may be induced by lifetime stressors and act in concert with advancing age to shape disease risk. The proposed fellow will first identify the DNA methylation sites that are regulated by stressors and ageing and will then examine how these epigenomic sites determine gene expression and disease outcomes. Among key biological processes, the project will focus on immune dysregulation, a common pathogenic process for several diseases of the ageing. Immune dysregulation will be examined in the periphery but also in the brain, the orchestrator of behavioral, neuroendocrine and immune responses. The project will engage translational approaches using both human samples and animal models, implemented via collaborations among leading institutions and experts in Europe and USA. The applicant has unique interdisciplinary skills to carry out the project, including clinical background as well as experience in both clinical and basic research projects on the two fields brought together in the proposal, the biology of stress and ageing-related diseases. The impact of the project can be tremendous, since elucidating the molecular mechanisms of ageing-related diseases would contribute to the development of biomarkers, targeted prevention strategies and novel treatments for these devastating diseases.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 194900;653828;ITS OBSERVATORY;SIGNED;H2020-EU.3.4.;MG-7.2b-2014;H2020;ITS Observatory;1/05/2015;30/04/2017;;"'The proposal is to create an ITS Observatory providing easily accessible and understandable information on Intelligent Transport Systems. The main objectives of the ITS Observatory are to bridge knowledge fragmentation across Europe, support ITS deployment by creating an intelligent software platform, create an efficient user-friendly decision-making tool which will enable fact based policy making and to create a common EU Library for ITS projects, research, pilots and implementation.

The ITS Observatory will comprise three main elements; 1) a database of projects that have been completed or are underway, predominantly those with Commission funding/co-funding, 2) a mechanism for capturing factual up to date information about projects and 3) a front-end to allow users to make a range of inquiries.

In addition, the ITS Observatory will contain articles, briefing notes, fact sheets etc. illustrating results of ITS deployment.
The ITS Observatory responds to the call MG-7.2b-2014 Towards seamless mobility addressing fragmentation in ITS deployment in Europe of the Mobility for Growth call of the Transport challenge 'Smart Green and integrated transport of the EU Framework Programme for Research and Innovation Horizon 2020'. In particular, the ITS Observatory will directly address the objective to Reduce the thematic and geographical knowledge fragmentation.

The ITS Observatory will alleviate existing gaps and fragmentation of the European ITS landscape by providing decision makers and related stakeholders with access to reliable, understandable and coherent information on outcomes (benefits and impacts) of existing and ongoing ITS deployment, supporting them in developing fact-based policy objectives and strategies.

Through knowledge sharing the ITS Observatory will foster a faster take-up of deployment, avoiding reinventing the wheel and previously identified pitfalls and hence leading to larger scale implementation.'";1337259,5;1337259,5;H2020-MG-2014_SingleStage_B;CSA;EUROPEAN ROAD TRANSPORT TELEMATICSIMPLEMENTATION COORDINATION ORGANISATION - INTELLIGENT TRANSPORT SYSTEMS & SERVICES EUROPE;BE;"REDWEB APS;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;AALBORG UNIVERSITET;TRANSPORT SYSTEMS CATAPULT LIMITED;AUSTRIATECH - GESELLSCHAFT DES BUNDES FUR TECHNOLOGIEPOLITISCHE MASSNAHMEN GMBH;UNIVERSITY OF NEWCASTLE UPON TYNE;Automobile Club d'Italia;XEROX BUSINESS SERVICES (NETHERLANDS) BV;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS";"DK;EL;UK;AT;IT;NL"; 194830;653040;CONFAM;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Confronting sexual pluralism: the regulatory dilemmas and policy challenges of non-monogamous family formations;;;;This project addresses the question of how the state should deal with radical sexual pluralism, and in particular how it should take up the challenges and difficulties raised for law and public policy in accommodating non-monogamous relationships and family formations. This is a multidisciplinary project drawing on diverse research sources (political philosophy, normative theory, social science data, doctrinal analysis, face-to-face in-depth interviews, and focus groups). It will explore models of non-monogamy particularly polyamory and polygamy in the UK to understand how they might pose a both legal and social challenge to traditional family law and regulation. This study thus provides a lens and case-study through which a core question for contemporary public policy is addressed: what legal and public policy instruments could and should the state adopt to deal with sexual and socio-cultural difference? The research will be conducted in four Work Packages (WPs). WP1 will critically assess the available literature on the social character, public relevance and legal status of non-monogamous relationships and family formations vis--vis monogamous ones. WP2 will involve in-depth semi-structured interviews with members of polyamorous and polygamous relationships and families to understand how law in its current form is experienced and the problems complex family forms face. WP3 will offer a philosophical-political analysis of the question of if and how the state should devise policy measures for the recognition of polyamorous and polygamous relationships and whether the best strategy is the production of a new relationship-recognition model, defined by specific legal provisions, or, conversely, the recognition of the contractual will of the parties. WP4 will involve members of relevant civil society organisations and state institutions in two focus groups to review the findings and indicate research gaps, potential biases, and areas for further development.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF KENT;UK;;; 194951;654216;AGRAL;SIGNED;H2020-EU.2.1.5.3.;SILC-II-2014;H2020;Development of the optimum AGRAL cermet manufacturing process for aluminium inert anode application and fuel cell interconnect plates.;1/05/2015;30/04/2018;;"The AGRAL (Advanced Green Aluminium anode) project will aim at developing the manufacturing technologies of a specific cermet (called AGRAL cermet within this proposal) that has shown at lab scale outstanding properties in high temperature and corrosive media i.e. aluminium electrolysis. Furthermore, this AGRAL cermet enables Aluminium Pechiney, leader of this project, to consider the replacement of their current carbon anode by this inert anode thus decreasing to zero the CO2 emission during electrolysis process. Furthermore this AGRAL cermet will be tested for two applications: aluminium electrolysis (for the manufacturing of an inert anode up to industrial scale) and for protection of interconnect plates in hydrogen and fuel cell application (up to pre-prototype scale). This AGRAL cermet will be used as an inert anode in the Aluminium industry. Thanks to the inert anode, it is expected to decrease by a minimum of 50% of CO2 emissions compared to currently used carbon anode. Then, the transfer to the fuel and hydrogen cell applications will be studied.
To reach the objectives, the partners will aim at:
- Developing the manufacturing process for the AGRAL cermet coating for aluminium electrolysis
o The Thermal Spray coatings: HVOF (combined eventually with Cold Spray) and eGun (HVOF with ethanol, technology developed by Flame Spray Technologies)
o The Powder Metallurgy Process : HIP and Ultraflex (technology developed by Kennametal Stellite)
The final manufacturing process will be adapted to large dimension (an anode is 1m long) and to complex shape (plates, grid).
- Developing qualification test for real scale inert anode to detect failure of the anode operation
- Developing the manufacturing process for the AGRAL cermet coating for hydrogen and fuel cell interconnect plates
The economic viability and the environmental impact of both the inert anode and its manufacturing process and the fuel cell application along their whole life cycle, will be monitored.";8440555,86;5232146,13;H2020-SILC-II-2014;IA;ALUMINIUM PECHINEY;FR;"ECOLE NATIONALE D'INGENIEURS DE SAINT-ETIENNE;FLAME SPRAY TECHNOLOGIES B.V.;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;ECOINNOVAZIONE SRL;BODYCOTE SPECIALIST TECHNOLOGIES DEUTSCHLAND GMBH;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;CRONITE CZ SRO";"FR;NL;IT;DE;CZ"; 194939;654154;KGBVIFEF;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Utilizing the fusion machinery of Herpes Simplex Virus to unveil the general process of membrane fusion;1/05/2015;30/04/2017;;Membrane fusion is a basic cell biological process found in diverse pathways ranging from vesicle trafficking and cell division to viral host entry. It is mediated by fusion proteins residing in the membrane. The underlying molecular mechanisms are supposed to follow a common order of events, i.e. fusion through hemifusion. Cell entry of Herpes simplex virus-1 (HSV-1) is enabled by glycoproteins residing on the viral envelope membrane. In contrast to other viruses, this is accomplished by different glycoprotein species, mediating together the attachment and subsequent fusion between the viral and host cell membrane. At least four of these proteins are essential for membrane deformation leading to fusion pore formation. In the here proposed project, I will take advantage of the modularity of the HSV-1 fusion machinery to dissect this process into discrete steps which I will analyse in situ at molecular resolution to determine the molecular details of membrane fusion. To do so, I will employ a multidisciplinary approach combining methods and data from structural biology, biochemistry as well as biophysics and molecular dynamics to solve the mechanistic details of a cell biological question. This includes fluorescence and cryo electron microscopy and tomography full-length membrane glycoprotein purification and biochemical reconstitution methods, biomolecular interaction and structural X-ray analysis, sub-volume averaging and classification as well as single particle imaging. To find the nenecessary triggers for fusion I will reconstitute the complete fusion system and thereby reveal the spatio-temporal changes that catalyse the fusion process. Taken together this structure-functional study will enable insights into hitherto ill-characterised intermediates in the conserved mechanism of membrane fusion. This project is a great opportunity to expand my research competence at the interphase of different fields ranging from cellular and structural biology to biophysics.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194949;654206;TANDEM;SIGNED;H2020-EU.1.4.3.;INFRASUPP-7-2014;H2020;TransAfrican Network Development;1/05/2015;30/04/2017;;"The TANDEM project aims to create favourable conditions for WACREN (West and Central African Research and Education Network) to be able to participate in the forthcoming AfricaConnect project extension and to draw maximum benefit from it, and thereby to ensure WACRENs integration into the global Research and Education networking community. TANDEM long-term goal is to make it possible for researchers and academics to contribute with their peers around the world to the socio-economic development of the West and Central African Region. To this end, TANDEM is structured around three objectives:

1. Enhance the dialogue between WACREN and policy makers, international donors and regulating authorities, in order to promote connectivity and obtain political and financial support;
2. Enhance the dialogue between WACREN, end users, national research and education networks (NRENs) and research and tertiary education institutes, in order to identify the global e-infrastructure services expected by the end users;
3. Build a permanent stakeholder dialogue by creating favourable conditions for the implementation of three main communities: the policy makers, donors and regulating authorities community; the NRENs community; the end users community.

TANDEM provides for the implementation of a virtual collaboration platform in order to support the continuity of communities beyond the end of the project, and to enable monitoring of the e-infrastructure services. In order to respond to the growing demand from African research communities, TANDEM is focused on three key research thematic topics: health, food security, and environment; and on the specific needs of these areas. The consortium was carefully selected to provide a balanced mix of research and e-infrastructure organisations, with diverse experiences in academic issues, research and innovation management. The consortium also brings consolidated experience in implementing and managing large research and education networks";1217982,5;1217982,5;H2020-INFRASUPP-2014-2;CSA;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;FR;"SIGMA ORIONIS SA;GROUPEMENT D INTERET PUBLIC POUR LERESEAU NATIONAL DE TELECOMMUNICATIONS POUR LA TECHNOLOGIE L ENSEIGNEMENT ET LA RECHERCHE;CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC;WEST AND CENTRAL AFRICAN RESEARCH AND EDUCATION NETWORK;THE UBUNTUNET ALLIANCE FOR RESEARCH AND EDUCATION NETWORKING;COOPERACION LATINOAMERICANA DE REDES AVANZADAS;BRUNEL UNIVERSITY LONDON;GEANT LIMITED";"FR;GH;NL;UY;UK"; 195015;654916;HydroCat;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding the Collective Behaviour of Catalytically-Driven, Self-Propelled Colloids: From Fine-Grained Hydrodynamic Simulations to Effective Field-Theoretical Descriptions;16/11/2015;15/11/2017;;"HydroCat proposes a simulation and theory study into the collective behaviour of catalytically-driven, self-propelled colloids. The first step of the investigation focusses on understanding the mechanism by which platinum-coated Janus particles self-propel on a single-particle level. This will be accomplished by modelling the two candidates for the mechanism, self-diffusiophoresis and self-electrophoresis, and directly comparing the behaviour of the hybrid-model to experimental results. Once sufficient insight has been achieved, the focus of the project will shift to the description of the collective behaviour of these particles. Here, HydroCat follows a three-pronged strategy: (i) development of a finely-resolved lattice-Boltzmann (LB) simulation that takes into account all relevant physical effects and is capable of simulating a large number of particles; (ii) coarse-grained molecular dynamics simulations to study the collective behaviour of these Janus colloids, which are benchmarked against the fine LB simulations; and (iii) a fully coarse-grained, field-theoretical description that uses input from both (i) and (ii). HydroCat will result in an improved understanding of the catalytic self-propulsion, which will serve as a solid foundation for the description of experiments and the development of applications.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 194967;654426;EQRESFRAME;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Earthquake-resilient self-centering steel frame;31/08/2015;30/08/2017;;"An important requirement of performance-based earthquake engineering is the simultaneous control of structural and non-structural damage. Structural damage measures are related to story drifts, inelastic deformations and residual drifts. Non-structural damage measures are related to story drifts and storey accelerations. Earthquake reconnaissance reports highlight that injuries, fatalities and economical losses related to failure of non-structural components far exceed those related to structural failures. Moreover, explicit consideration of non-structural damage becomes vital in the design of critical facilities such as hospitals carrying acceleration-sensitive medical equipment, which have to remain functional in the aftermath of an earthquake. Structural and non-structural damage results in direct and indirect losses such as repair costs and costly downtime during which the building is repaired and cannot be used or occupied. Therefore, there is an urgent need for minimal-damage structures that can truly achieve seismic resilience.
Researchers have developed self-centering frames with the goal of avoiding residual drifts. Other studies focused on increasing the energy dissipation capacity of structures by adding dampers with the goal of reducing storey drifts and storey accelerations. This project aims to couple, for the first time, self-centring systems and modern seismic energy dissipation systems with the goal of developing a novel earthquake-resilient steel frame. The optimal combined design of the self-centering and energy dissipation mechanisms will lead to a steel frame with superior minimal-damage seismic performance.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 194992;654734;SIW-SAT-ANTENNAS;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Circularly Polarized Antenna Arrays for Broadband Satellite Data Terminals Using Substrate Integrated Waveguides enhanced with Metamaterials;15/06/2015;14/06/2017;;"There is a currently increasing interest for broadband mobile satellite communications that can fulfil the Digital Agenda 2020 objective for fast Internet everywhere. Furthermore,European regulators have recently agreed to harmonize the spectrum for Earth Stations on Mobile Platforms that will use parts of the Ka-Band (17-30 GHz). Operators such as Inmarsat are planning to launch Ka-Band broadband satellite data services. New antennas and related components are required for the mobile terminals. It is proposed that broadband and miniaturized Circularly Polarized (CP) Antenna Arrays Using Substrate Integrated Waveguides(SIW) enhanced with metamaterials will be developed. SIW is a progressively important technology for millimeter waves and metamaterials (artificially macroscopic structures that mimic materials) have been transforming many wireless system components. Few papers have reported SIW CP antenna arrays and no compact flat antenna designs have yet been published for such applications. Antenna arrays with at least 8x8 elements are expected to satisfy link budget requirements. A synthetic approach is proposed that combines SIW with metamaterials for miniaturization and broadbanding. Moreover, evolutionary algorithms are exploited for efficient array geometry optimization in order to reach the desired broadband performance. Complementary circuit components will also be investigated; waveguide transitions and couplers that affect the size of the feeding network and consequently the array size. The innovative antennas coming out of this project can contribute to a competitive advantage for European industry and have an impact on the adoption of broadband mobile satellite Internet. The IPR potential is significant and offers future research opportunities on antennas for emergent millimeter wave applications. Moreover, the training plan arms the experienced researcher with research management skills that are critical to arrive at a leading independent position.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE TECNOLOGIC DE TELECOMUNICACIONS DE CATALUNYA;ES;;; 195128;655542;MeaSuRe;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Following Protein Diffusion in Photosynthetic Membranes with Super Resolution;14/09/2015;13/09/2017;;"The regulated diffusion of light-harvesting complexes in photosynthetic membranes is essential for photosynthesis, for instance for the redistribution of light-harvesting complexes between Photosystems I and II. To date, however, little is understood about the mobility of these proteins through the highly crowded membrane environment. In contrast to the huge amount of structural research that has been performed on biomolecules in the past, research on the dynamics is lagging far behind. The major limitation is the fact that the nanometer size regime of biomolecules is not accessible by classical optical techniques owing to the diffraction limit of light. To overcome this problem, we propose to use plasmonic nanoantennas, which are able to confine light at the nanoscale. In combination with Fluorescence Correlation Spectroscopy (FCS) this will allow measuring protein mobility in photosynthetic membranes with high, tens of nanometers, resolution. Directional and functional protein movement will be induced by illumination of the chloroplasts using specific light conditions; simultaneously following the protein movement will give new insights in how plants optimize their light harvesting capacity under fluctuating light conditions. The new nanoantenna-FCS based method, which we will develop to measure the diffusion of membrane proteins with nanometer resolution, has the potential to become widely used for nanobioimaging and ultrasensitive biosensing.
This research will be performed by Dr. E Wientjes in the Laboratory of Biophysics of Wageningen University led by photosynthesis expert Prof. H van Amerongen. A long-term collaboration will be started with Wientjes current supervisor Prof. NF van Hulst and Prof. MF Garcia-Parajo from the Institute of Photonic Sciences in Barcelona who are leading scientists in nanophotonics. The outcome of this project will provide biophysicists with a new method to study membrane protein dynamics with super resolution.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;WAGENINGEN UNIVERSITY;NL;;; 194824;652965;Bio-Strategies;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bio-strategies of mineral nutrient extraction from silicates by selected microorganisms;1/09/2015;31/08/2017;;"This project will investigate the mutual influence between minerals, microorganisms and lower land plants and their strategies to release and assimilate metal nutrients from minerals. The study encompasses (1) the habitability of silicate mineral substrates for microbes, (2) the strategies used by microorganisms to obtain metal nutrients from minerals of different nutrient content and resilience to nutrient release, (3) the routes of the metal nutrient from the mineral to the microorganisms and plants.

Individual microbes will be inoculated on individual silicate minerals with different resilience to weathering and mineral nutrient content, representing a series of progressively degraded soils or sediments. After these experiments, bathing solutions will be transferred to (1) moss cultures and (2) liverwort cultures with and without fungus symbionts.

Microscopic techniques will investigate mineral-microbe interaction, topographic and chemical alteration features in the mineral grains. Chemical analyses will investigate siderophore production, cations dissolved and adsorbed on biofilms, and pH at the mineral-biofilm interface. The bioavailability of leached metals to bryophytes will be measured by chemical analysis of the plants and morphological indications of nutrient stress. Results from bryophytes with and without fungal symbionts will indicate the route of metal assimilation by plant.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;NATURAL HISTORY MUSEUM;UK;;; 194896;653753;CUIDAR;SIGNED;H2020-EU.3.7.;DRS-21-2014;H2020;Cultures of Disaster Resilience among children and young people;1/07/2015;30/06/2018;;"Cultural sensitivity is essential to effective disaster management and disaster risk reduction, yet disaster plans still largely ignore the needs and capacities of children and young people. Addressing Topic 2 of this call, the given cultural group is therefore children, not viewed as a homogenous group, but one which offers diverse cultural perspectives and diverse experiences of roles taken on in disasters. By culture we mean more than ethnicity, important though that is; we also refer to social class, vulnerability, age, gender, disability and migration status. Cultures of Recovery and Resilience among children and young people in Disasters (CUiDAR) will address the exclusion of children and young people from the disaster planning and management process; it will provide innovative and creative communication channels for childrens voices to be heard and it will develop a child centred disasters management framework for use by policy/decision makers in participating countries, the EU and beyond. To achieve the objectives we have designed a suite of activities: scoping; dialogues with children (consultative workshops); regional level mutual learning exercises; national level awareness and communication events; framework design/building, and an in-depth ongoing approach to dissemination. Our unique partnership with the major childrens charity Save the Children enables the Consortium to work closely with children to achieve our objectives. Our strong existing links with emergency planners and authorities enables us to access key audiences. Each workpackage is designed to create stronger awareness of needs and capacities of children and will enable enhanced local, national and EU institutional and policy response for what is a growing and urgent societal problem: how to develop meaningful and effective disaster management (including response, recovery and resilience).";2009653,5;2009653,5;H2020-DRS-2014;CSA;LANCASTER UNIVERSITY;UK;"FUNDACIO PER A LA UNIVERSITAT OBERTA DE CATALUNYA;SAVE THE CHILDREN ITALIA ONLUS ASSOCIAZIONE;PANEPISTIMIO THESSALIAS;THE SAVE THE CHILDREN FUND;INSTITUTO DE CIENCIAS SOCIAIS DA UNIVERSIDADE DE LISBOA";"ES;IT;EL;UK;PT"; 194901;653846;Fractional;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Fractionalized quantum matter: Characterization, realization and generalization;2/11/2015;1/11/2018;;"With the advent of topological phases, we have recently witnessed a revolution in our understanding of different phases of matter. They are described by tools borrowed from mathematical topology, unlike more familiar phases such as (ferro)magnets, classified in terms of symmetry breaking. Within these topological phases, fractionalized states of matter are of the most exotic, intriguing and potentially useful kind. They result from the delicate interplay between strong correlations among its constituents and the topological nature of the parent non-interacting state. They carry fractional quantum numbers and topologically protected excitations, insensitive to local system details (e.g. impurities) and key to efficient, fault-tolerant quantum computation. The fractional quantum Hall effect (FQHE) is still the hallmark of such phases but it needs strong magnetic fields and low temperatures to be realized, severely constraining the latter groundbreaking scientific leap.
Thus, this project aims to reach a new milestone concerning fractionalized phases to foster possible realizations and open the next door towards the quantum computing revolution. To this end, an innovative interedisciplinary approach is required. First, a numerical study beyond the widely used exact diagonalization will characterize fractional Chern insulators (FCI), FQHE analogues that dispose of the need of external magnetic fields, strongly focusing on experimentally relevant features, in particular dynamical signatures, still largely unexplored. Second, it proposes a new topologically trivial to FCI route to realize these phases while critically assessing existing proposals and the role of possible competing orders that can jeopardize the emergence of fractionalization. Lastly, it will investigate effective quantum field theories that can generalize fractionalization to three dimensional topological phases in interacting Weyl semi-metals, providing an new landmark in the search for these states.";251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194936;654139;LEARN;SIGNED;H2020-EU.1.4.3.;INFRASUPP-7-2014;H2020;Leaders Activating Research Networks: Implementing the LERU Research Data Roadmap and Toolkit;1/06/2015;31/05/2017;;"We live in the age of the data deluge, where digital technology enables us to store petabytes of data and to make that available for sharing as open data. Sharing data has the potential to revolutionise the way that researchers work. It avoids costly duplication in the collecting of data and enables research collaborations across the world which otherwise would not be possible.

The purpose of this bid is to take the LERU Roadmap for Research Data produced by the League of European Research Universities (LERU) and to develop this in order to build a coordinated e-infrastructure across Europe and beyond. LEARN will deliver a model research Research Data Management (RDM) policy, a Toolkit to support implementation, and an Executive Briefing in five core languages so as to ensure wide outreach.

LEARN will hold a series of Workshops within four European countries and one international country. The workshops will serve to advocate the Recommendations on RDM and open data made by the LERU Roadmap, and gain feedback from Workshop attendees for a new Toolkit of best practice. Furthermore, guidance to implement the Roadmap will be provided following identification of Best Practices supported by case studies identified through the workshops.

By producing an exemplar RDM policy, which could then be tailored by any university or research institution to meet their needs, LEARN aims to address the challenges of the Work Programme concerning the fragmentation of e-infrastructures and the need to maximize on global research data. Specifically, LEARN will address Stakeholder initiatives; Policy coordination; Take-up of digital infrastructures; and Support cooperation with developing countries. LEARN thus delivers support actions to quicken the take-up of RDM and the move to open data in the emerging world of Science 2.0.";496582,5;496582;H2020-INFRASUPP-2014-2;CSA;UNIVERSITY COLLEGE LONDON;UK;"STICHTING LIBER;UNIVERSITAT WIEN;UNIVERSITAT DE BARCELONA;UNITED NATIONS ECONOMIC COMMISSION FOR LATIN AMERICA AND THE CARIBBEAN";"NL;AT;ES;CL"; 194925;654020;STRATNARRA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Russia's strategic narrative of the West: A study of influence in Ukraine;1/09/2015;31/08/2018;;"This project investigates the relationship between mass communication and influence in 21st Century international relations. It does so through a study of Russias official and media narratives about the West and their reception in Ukraine. Success in todays information age is said to depend on whose story wins. Emerging powers such as Russia have developed various policies and instruments under the banner of soft power to challenge Western hegemony in global media discourse. The projection of counter-hegemonic narratives has been documented extensively, yet we still understand little about their reception and the extent of their influence among target audiences.
Anti-Western narratives have been a distinguishing feature of the Russian public sphere during Vladimir Putins third presidential term. The narratives of Russian politicians and state media characterize the West as a destabilizing force which backs, even orchestrates, illegitimate regime change. Russian narratives are easily accessible among some audiences in Ukraine for reasons of language and overlapping media environments. This project employs a survey, focus groups and interviews to study the assimilation or otherwise of negative narratives about the West among Ukrainians. It concentrates on three groups as case studies: MPs, a regional business community and students from a regional university.
The projects principal goal is to identify factors which condition assimilation of anti-Western ideas from Russian strategic narratives, in order to explain when and why they are accepted or eschewed. A second goal is to advance research on power and communication in international affairs by applying the new conceptual framework of strategic narrative in a detailed empirical study. Thirdly, the project aims to generate practical insights to help improve the effectiveness of EU engagement with Ukraine. A secondment to the UK Foreign Office is incorporated to facilitate knowledge exchange.";243934,2;243934,2;H2020-MSCA-IF-2014;MSCA-IF-GF;ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE;UK;;; 195017;654921;Phonetic Processing;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Phonetic Processing in Bilinguals: Investigation of the bilingual advantage hypothesis in phonetic processing;1/07/2015;;;"Bilinguals manage sound (phonetic) systems of two languages. This practice might cause some differences in the nature of phonetic processing of bilinguals compared to monolinguals, a difference to be examined in the proposed research. Some recent neuroimaging studies suggest that special neural circuitry is used by bilinguals in non-native speech perception and that this circuitry provides them with more phonetic sensitivity than monolinguals (Arcilla-Suerte et al., 2013; Petitto et al., 2012). However, only the phonetic sensitivity of bilingual babies has been tested so far. The goal of the proposed research is to address this preliminary hypothesis of the bilingual advantage in phonetic processing by looking at the performance of bilingual adults in phonetic processing tasks. In particular, we plan to assess (1) bilinguals sensitivity to co-articulatory cues and (2) the effect of auditory cues (foreign accent) on code-switching costs. If the bilingual advantage hypothesis in phonetic processing is indeed correct, then, we should observe an increase in sensitivity of bilinguals to co-articulatory cue violations and to the presence of accented speech compared to monolinguals. These differences are likely to be observed in behavioural, electroencephalographic (EEG) and neuroimaging (fMRI) responses of two groups. The performance of bilinguals in their native (L1) and non-native languages (L2) will be assessed. In addition, the effects of such factors as L2 age of acquisition, L1 and L2 proficiency, and similarity of phonetic systems of L1 and L2 on the magnitude of phonetic sensitivity will be examined. The outcome of the proposed research has inter-disciplinary impact as it will be of scientific value to psychologists, linguists investigating language processing in bilinguals, educators, and speech/language pathologists working with bilingual populations.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE;ES;;; 194885;653569;SMR;SIGNED;H2020-EU.3.7.;DRS-07-2014;H2020;Smart Mature Resilience;1/06/2015;31/05/2018;;"Smart Mature Resilience (SMR) will develop and validate Resilience Management Guidelines, using three pilot projects covering different CI security sectors, as well as climate change and social dynamics. The Resilience Management Guidelines will provide a robust shield against man-made and natural hazards, enabling society to resist, absorb, accommodate to and recover from the effects of a hazard in a timely and efficient manner, including through the preservation and restoration of essential structures and functions. A set of tools operationalize crucial interdependent supporting structures of the Resilience Management Guidelines: 1) a Resilience Maturity Model defining the trajectory of an entity through measurable resilience levels; 2) a Systemic Risk Assessment Questionnaire that, beyond assessing the entitys risk, determines its resilience maturity level; 3) a portfolio of Resilience Building Policies that enable the entitys progression towards higher maturity levels; 4) a System Dynamics Model allowing to diagnose, monitor and explore the entitys resilience trajectory as determined by resilience building policies, and, 5) a Resilience Engagement and Communication Tool to integrate the wider public in community resilience, including public-private cooperation.
Beyond delivering the validated Resilience Management Guidelines and the five supporting tools, the SMR project establishes a European Resilience Backbone consisting of vertebrae (adopters, from fully committed through direct project participation to alerted potential adopters).
The SMR projects powerful impact maximizing measures will assist the implementation of the Resilience Management Guidelines by consolidating the resilience vertebrae as mutually supporting functional units of the European Resilience Backbone.
The five tools operationalizing the five crucial interdependent supporting structures of the Resilience Management Guidelines will be commercialized, targeting users in Europe and beyond";4641233,25;4641233,25;H2020-DRS-2014;RIA;UNIVERSIDAD DE NAVARRA;ES;"KRISTIANSAND KOMMUNE;LINKOPINGS UNIVERSITET;DIN DEUTSCHES INSTITUT FUER NORMUNG E.V.;UNIVERSITETET I AGDER;GLASGOW CITY COUNCIL;ICLEI EUROPEAN SECRETARIAT GMBH (ICLEI EUROPASEKRETARIAT GMBH)*;ROMA CAPITALE;BRISTOL CITY COUNCIL;VEJLE KOMMUNE;RIGAS DOME;AYUNTAMIENTO DE DONOSTIA SAN SEBASTIAN;UNIVERSITY OF STRATHCLYDE";"NO;SE;DE;UK;IT;DK;LV;ES"; 194934;654124;SoNDe;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-1-2014;H2020;Solid-State Neutron Detector - A new Neutron Detector for High-Flux Applications;1/05/2015;30/04/2019;;"The Solid-State Neutron Detector SoNDe project aims to develop a high-resolution neutron detector technique that will enable the construction of position-sensitive neutron detectors for high-flux sources, such as the upcoming European Spallation Source (ESS). Moreover, by avoiding the use of 3He in this detector the 3He-shortage, which might otherwise impede the construction of such large-scale facilities, can be alleviated. The main features of the envisioned detector technique are:

high-flux capacity, capable of handling the peak-flux of up-to-date spallation sources
high-resolution down to 3 mm by direct imaging technique, higher resolutions available by interpolation
no beam stop necessary, thus enabling investigations with direct beam intensity
independence of 3He
modularity, improving maintenance characteristics of todays neutron detectors

Detectors of these kind will be capable of usage in a wide array of neutron instruments at facilities which use neutrons to conduct there research, among them the Institute Laue-Langevin (ILL) in France, the Maier-Leibnitz-Zentrum (MLZ, former FRMII) in Germany, Laboratoire Leon Brillion (LLB) in France and ISIS in the United Kingdom which are in operation at the moment and the upcoming ESS. At these facilities neutrons are used as a probe in a wide array of fields, ranging from material science to develop new and smart materials, chemical and biological science to develop new drugs for improved treatment of a wide range of medical conditions, magnetic studies for the development of future information storage technology to archeology, probing historical artifacts without physically destroying them. All these fields nowadays rely heavily on neutrons scattering facilities in their research and thus are in need of a reliable, high-quality neutron detection technique, which will be able to perform well at the new high-flux facilities such as ESS and simultaneously avoid the problem of 3He shortage.";3800932,5;3800932,5;H2020-INFRADEV-1-2014-1;RIA;FORSCHUNGSZENTRUM JULICH GMBH;DE;"EUROPEAN SPALLATION SOURCE ESS AB;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;INTEGRATED DETECTOR ELECTRONICS AS;LUNDS UNIVERSITET";"SE;FR;NO"; 194977;654534;PREDICTIVEMEMORY;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Multimodal neuroimaging of mechanisms supporting memory-based predictions in the human brain;1/06/2015;31/05/2016;;The human brain is constantly and automatically forming predictions (e.g., how a ball will bounce off soccer turf or what another person will say). In cognitive neuroimaging studies of Dr. Jskelinen (Experienced Researcher) and colleagues at Aalto University, Finland, it has become one of the most central research questions how the brain predicts complex dynamic events unfolding in naturalistic stimuli such as movies. Here, our main objective is that Dr. Jskelinen will acquire the specific expertise to address this question by working for one year in Gonda Multidisciplinary Brain Research Center of Bar-Ilan University, Tel Aviv, Israel, where there is unique empirical-theoretical expertise on predictive brain mechanisms. Work by the Director of Gonda Center, Prof. Moshe Bar (Supervisor), suggests that rapid derivation of analogies (what does this object resemble) from sensory inputs and associative linking of these to memory representations supports predictions (e.g., seeing a kettle predicts cooking rather than swimming activity). We hypothesize that distributed patterns of brain activity, generated by the associative process, underlie the memory representations that support predictions. To test this, experimental paradigms developed by Prof. Bar et al. will be combined with data analysis methods used by Dr. Jskelinen et al. In addition to ambitious science, the proposed fellowship has the following objectives: 1) significant deepening and diversification of Dr. Jskelinens cognitive neuroscience expertise at Gonda Center, 2) transfer of data analysis and cognitive neuroscience expertise of Dr. Jskelinen to Gonda Center, 3) networking of scientists between Bar-Ilan and Aalto for further collaboration, 4) opening up of a new important research area, and 5) catalyzing of Dr. Jskelinens scientific career. The fellowship also contributes to knowledge-based economy and society by building foundation for artificial intelligence and clinical research.;91254,6;91254,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;BAR ILAN UNIVERSITY;IL;;; 195000;654818;ELECTRONANOMEGA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;DEVELOPMENT OF OMEGA-3 NANODELIVERY SYSTEMS USING ELECTROSPINNING PROCESSING;24/08/2015;23/08/2017;;"Functional foods containing omega-3 lipids, which have approved health claims by EFSA, have resulted in one of the fastest-growing food product categories in Europe. However, to successfully develop foods enriched with omega-3 PUFA, lipid oxidation of these highly unsaturated fatty acids must be prevented in order to avoid both the loss of nutritional value and the formation of unpleasant off-flavors.
Omega-3 PUFA can be added to foods as neat oils or as a delivery system such as microencapsulated oil powders and oil-in-water emulsions. Nevertheless, delivery of omega-3 lipids in the form of emulsions reduces the oxidative stability of omega-3 PUFA in some products. Furthermore, microencapsulates are less suitable for liquid or semi-liquid foods than emulsified omega-3 oils due to handling/mixing issues.
Therefore, the development of alternative omega-3 PUFA delivery systems, which are easy to disperse and which will lead to improved oxidative stability of omega-3 enriched food products, is urgently required. One of the more promising delivery systems can be functional nano-microstructures obtained by electrospinning technology, which is possible to up-scale.
In light of the above, the aim of this research project is to develop advanced omega-3 delivery systems such as electrospun nano-microstructures. To this end, the specific objectives are:
1) Development of physically and oxidatively stable nano-microstructures with omega-3 PUFA and natural antioxidants using electrospinning processing.
2) Production of food enriched with the nano-microstructures having appropriate structural-functional properties and being oxidatively stable.
The success of the research proposed will lead to an important advance in the protection of omega-3 PUFA against oxidation when incorporated into food. Thus, the knowledge generated by this study has the potential to being exploited by companies devoted to the production of functional foods containing omega-3 lipids.";200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;DANMARKS TEKNISKE UNIVERSITET;DK;;; 194921;654019;OTULINVIVO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The role of OTULIN and Met1-linked ubiquitin in immune signaling and host defense in vivo;1/04/2015;31/03/2017;;"The immune system is essential for host defense against infections. Methionine1-linked linear ubiquitin chains (Met1-Ub) have emerged as a crucial activator of NF-?B transcription factors, which are vital to immune responses. Recent findings suggest that defects in Met1-Ub signaling in humans can lead to severe immune dysfunction and cancer. Met1-Ub is generated by the linear ubiquitin chain assembly complex (LUBAC). Yet, how LUBAC and Met1-Ub signaling are regulated remains elusive. We recently discovered OTULIN, the only deubiquitinase known to specifically disassemble Met1-Ub. OTULIN antagonizes LUBAC and restricts Met1-Ub and NF-?B signaling in cell culture; however, the role of OTULIN and Met1-Ub in immune signaling and host defense in vivo is largely unknown. We have established novel mouse strains with cell type-specific deletion of OTULIN. I will use these mice to explore the in vivo function of OTULIN and Met1-Ub in the innate and adaptive immune responses, and to identify OTULIN substrates in primary cells using state-of-the-art mass spectrometry-based proteomics. I will study OTULINs role in immune homeostasis, in response to bacterial infection, and in mounting type-1 and type-2 adaptive immune responses by state-of-the-art methods of immunological analyses including comprehensive multiplex analyses of cytokines. Met1-Ub regulates the acute phase cytokines TNF and IL-6 and may thus control the development of type-1 versus type-2 immune responses. Hence, I will test OTULINs role in models of asthma, a disorder characterized by an imbalance between type-1 and type-2 responses. Subsequently, I will analyze immune signaling pathways in primary cells using mass spectrometry-based proteomics to identify OTULIN substrates in specific cell types. This will greatly deepen our understanding of the physiological role of OTULIN and Met1-Ub in the immune response and may provide important insight into human immunological disorders and rationales to treat these.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MEDICAL RESEARCH COUNCIL;UK;;; 194952;654237;Sci-GaIA;SIGNED;H2020-EU.1.4.3.;INFRASUPP-7-2014;H2020;Energising Scientific Endeavour through Science Gateways and e-Infrastructures in Africa;1/05/2015;30/04/2017;;In African Communities of Practice (CoPs), international collaboration and the pursuit of scientific endeavour has faced a major barrier with the lack of access to e-Infrastructures and high performance network infrastructure enjoyed by European counterparts. With AfricaConnect, the proposed AfricaConnect2 and regional developments, this situation is changing rapidly. In the project Teaming-up for exploiting e-Infrastructures' potential to boost RTDI in Africa (eI4Africa) it has been demonstrated clearly that it is possible to develop e-Infrastructures in Africa. It has also been demonstrated clearly that, as with the rest of the world, easy to use web portals, or Science Gateways, are needed to help CoPs to easily access e-Infrastructure facilities and through these collaborate with CoPs across the world. However, a major problem exists: it is very difficult for non-experts to develop Science Gateways and supporting e-Infrastructures. Elements of guides and supporting materials exist but these are either written for different audiences or out of date. This present Coordination and Support Action, called Energising Scientific Endeavour through Science Gateways and e-Infrastructures in Africa (Sci-GaIA), therefore proposes to bring together these materials into clearly structured guides and educational documents that can be used to train and support representatives of NRENs, CoPs and, importantly, Universities to develop Science Gateways and other e-Infrastructures services in Africa. Sci-GaIA plans to work with new and emerging CoPs to develop these exciting technologies, to strengthen e-Infrastructure service provision, especially in terms of open access linked data, and to deliver training and dissemination workshops. This will give a sustainable foundation on which African e-Infrastructures can be developed and be linked to scientific networks across Africa. Importantly, the results of our project will be usable by CoPs in Europe and the rest of the world.;1339125;1339125;H2020-INFRASUPP-2014-2;CSA;BRUNEL UNIVERSITY LONDON;UK;"SIGMA ORIONIS SA;COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH;KUNGLIGA TEKNISKA HOEGSKOLAN;UNIVERSITA DEGLI STUDI DI CATANIA;WEST AND CENTRAL AFRICAN RESEARCH AND EDUCATION NETWORK;THE UBUNTUNET ALLIANCE FOR RESEARCH AND EDUCATION NETWORKING;KAROLINSKA INSTITUTET;DAR ES SALAAM INSTITUTE OF TECHNOLOGY";"FR;ZA;SE;IT;GH;NL;TZ"; 195113;655474;FluoroCAT;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Catalytic CF Bond Functionalisation with Transition Metal Catalysis;15/03/2015;14/03/2017;;Fluorinated organic molecules play a pivotal role in chemical manufacture. For example, it has been estimated that approximately 20-40% of pharmaceuticals and agrochemicals contain at least one fluorine atom. Despite the fact that perfluoroarenes - aromatic hydrocarbons in which every hydrogen atom is replaced with a fluorine atom - are an inexpensive abundant chemical feedstock they are rarely used in chemical manufacture. The strong carbonfluorine bond provides an impasse to further chemical reactions. Here we propose to develop a new catalytic method to transform inert carbonfluorine bonds in perfluoroarenes to reactive carbonaluminium bonds. We will transform the aluminium-containing reactive intermediates into useful products through carboncarbon and carbonheteroatom bond forming reactions. The overall process represents an original underpinning technology to transform inert and chemically persistent fluorinated molecules into building blocks that can be used in chemical manufacture. The ultimate goal of this work is to create a fresh paradigm for using perfluoroarenes in pharmaceutical and agrochemical programmes. The proposed programme will provide world-class training in the areas of organometallic chemistry, homogeneous catalysis and mechanistic analysis. The long-term benefits will be felt in the areas of health and food sustainability.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 195198;655978;GDA in staphylococci;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gen Duplication and Amplification in Staphylococcal populations;1/01/2016;31/12/2017;;Bacterial pathogens possess the ability to adapt rapidly to changing environmental conditions which is especially apparent in the hospital setting where bacteria acquire antibiotic resistances readily. Besides well studied mechanisms such as horizontal gene transfer bacteria can alter the genetic material by acquiring gen duplications and amplifications (GDA). Exemplarily an improved gene dosage of a minor resistance determinant can lead to increased resistance to antibiotics. Due to the difficulties in their detection GDAs are almost exclusively studied in model organisms and neglected in natural populations of clinically relevant species such as Staphylococcus aureus. Accordingly many important questions about the frequency and clinical importance of GDAs remain unanswered. State of the art sequencing technologies enable the identification of GDAs by analysis of the coverage scaffold and groundbreaking experiments using 387 USA300 genome sequences showed promising results regarding putative copy number variation of virulence factors. We will extend the GDA analysis to ca. 1200 already available EMRSA15 sequences. This will enable a comprising analysis of gen copy number variation in clinical isolates and might allow identifying genomic regions under strong evolutionary pressure during infection. We will optimize experimental setups for the rapid validation of GDAs by qPCR and develop techniques to study the effects of GDAs in S. aureus. Furthermore we will sequence a selection ca. 70 S. aureus isolates causing chronic infections in patients suffering from cystic fibrosis (CF). This will enable us to optimize the detection of GDAs by NGS and will allow investigating the role of GDAs during adaption to the complex environment within the CF-lung. This project will show new avenues to extract additional valuable biological information from NGS data and will investigate the importance of GDAs during the adaption of S. aureus to the hospital setting and to the CF-lung.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EBERHARD KARLS UNIVERSITAET TUEBINGEN;DE;;; 194870;653460;RESOLUTE;SIGNED;H2020-EU.3.7.;DRS-07-2014;H2020;RESilience management guidelines and Operationalization appLied to Urban Transport Environment;1/05/2015;30/04/2018;;Increasing Europes resilience to crises and disasters is a topic of highest political concern in the EU and its Member States and Associated Countries. Regarding the specific case of transport systems, it can be said that those have developed a prominent safety and business critical nature, in view of which current management practices have shown evidence of important limitations in terms of resilience management. Furthermore, enhancing resilience in transport systems is considered imperative for two main reasons: such systems provide critical support to every socio-economic activity and are currently themselves one of the most important economic sectors and secondly, the paths that convey people, goods and information, are the same through which risks are propagated. RESOLUTE is answering those needs, by proposing to conduct a systematic review and assessment of the state of the art of the resilience assessment and management concepts, as a basis for the deployment of an European Resilience Management Guide (ERMG), taking into account that resilience is not about the performance of individual system elements but rather the emerging behaviour associated to intra and inter system interactions. The final goal of RESOLUTE is to adapt and adopt the identified concepts and methods from the defined guidelines for their operationalization and evaluation when addressing Critical Infrastructure (CI) of the Urban Transport System (UTS), through the implementation of the RESOLUTE Collaborative Resilience Assessment and Management Support System (CRAMSS), that adopts a highly synergic approach towards the definition of a resilience model for the next-generation of collaborative emergency services and decision making process.;3848581,25;3848581;H2020-DRS-2014;RIA;UNIVERSITA DEGLI STUDI DI FIRENZE;IT;"COFAC COOPERATIVA DE FORMACAO E ANIMACAO CULTURAL CRL;COMUNE DI FIRENZE;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;CONSORZIO MILANO RICERCHE;ATTIKO METRO AE;SWARCO MIZAR SRL;HUMANIST;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;Thales Italia spa;ASSOCIACAO PARA O DESENVOLVIMENTO DA INVESTIGACAO NO INSTITUTO SUPERIOR DE GESTAO";"PT;IT;EL;FR;DE"; 194919;654003;GLOBIS-B;SIGNED;H2020-EU.1.4.3.2.;INFRASUPP-6-2014;H2020;GLOBal Infrastructures for Supporting Biodiversity research;1/06/2015;31/05/2018;;Biodiversity and ecosystem research is addressing the grand societal challenge to predict the biosphere under global environmental change. To advance scientific progress in understanding the complexity of natural systems it is required that supporting research infrastructures cooperate globally to serve the essential data at different temporal and spatial scales. This includes providing the capabilities to process big and massive datasets. GLOBIS-B is a global cooperation of world-class research infrastructures with a focus on targeted services to support frontier research that deals with predicting the biosphere and measuring the indicators of biodiversity change. The project brings key scientists together with global research infrastructure operators and legal interoperability experts to address research needs and infrastructure services underpinning the concept of Essential Biodiversity Variables (EBVs). EBVs were proposed by the GEO Biodiversity Observation Network (GEO BON) and are a prerequisite for understanding biodiversity and ecosystem change. Integrated scientific and technical workshops will identify the required primary data, analysis tools, methodologies etc. to develop an infrastructure development agenda for computing EBVs and to explore the discovery of required and interoperable data at larger spatial and temporal scales. Applications of common standards and workflows that are self-documenting and openly shared facilitate international cooperation, and realistic and pragmatic solutions are explored to streamline the legal bottlenecks for the reciprocal use of data and software tools from different origins. Solutions should be workable for both the scientific communities and the cooperating research infrastructures, especially in regard to achieving direct machine-machine interactions. The interaction with national, supra-national and global policy bodies contributes to potential refinements of general policies supporting legal interoperability.;1005875;1005875;H2020-INFRASUPP-2014-2;CSA;UNIVERSITEIT VAN AMSTERDAM;NL;"MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG;MAAT FRANCE SARL;UNIVERSIDAD DE ALCALA;CONSIGLIO NAZIONALE DELLE RICERCHE;CARDIFF UNIVERSITY";"DE;FR;ES;IT;UK"; 195002;654836;Bioelectroammonia;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Bioelectroreduction of nitrogen to ammonia: the incorporation of nitrogenase within enzymatic biological fuel cells for simultaneous production of electrical energy and ammonia.;1/06/2015;31/05/2018;;"Enzymatic biological fuel cells (EBFCs) utilise enzymes as biological catalysts to produce electrical energy from chemical energy, usually being fuelled by simple molecules such as glucose or ethanol, in the presence of O2. This technology provides an alternative to the use of expensive metal catalysts (such as platinum) and offers the ability for electrical energy to be produced under much milder conditions, such as near-neutral pH and room temperature. The cathodes of EBFCs usually employ O2 as the oxidant and final electron acceptor; this proposal seeks to utilise N2 in its place. Not only does the use of N2 as the oxidant circumvent issues relating to dissolved O2 concentrations and solubility (limited to less than 1 mM), but it also presents the possibility to produce industrially important NH3 (using a novel technology) whilst simultaneously producing electrical energy.";248063,4;248063,4;H2020-MSCA-IF-2014;MSCA-IF-GF;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;;; 194882;653549;INDIGO-DataCloud;SIGNED;H2020-EU.1.4.1.3.;EINFRA-1-2014;H2020;INtegrating Distributed data Infrastructures for Global ExplOitation;1/04/2015;30/09/2017;;"The INDIGO-DataCloud project (INDIGO for short) aims at developing a data/computing platform targeted at scientific communities, deployable on multiple hardware, and provisioned over hybrid (private or public) e-infrastructures. This platform will be built by leading European developers, resource providers, e-infrastructures and scientific communities in order to ensure its successful exploitation and sustainability.

All members of the consortium share the common interest in developing advanced middleware to sustain the deployment of service models and user tools to tackle the challenges of the Big Data era. INDIGO will exploit the formidable know-how that was built in Europe along the past ten years of collaborations on scientific computing based on different consolidated and emerging paradigms (HPC, Grid and Cloud).

Regarding Cloud computing, both the public and private sectors are already offering IaaS-type Cloud resources. However, numerous areas are of interest to scientific communities where Cloud computing uptake is currently lacking, especially at the PaaS and SaaS levels. The project therefore aims at developing tools and platforms based on open source solutions addressing scientific challenges in the Cloud computing, storage and network areas.

INDIGO will allow application development and execution on Cloud and Grid based infrastructures, as well as on HPC clusters. The project will extend existing PaaS solutions, allowing public and private e-infrastructures, including those provided by EGI, EUDAT, PRACE and HelixNebula, to integrate their existing services, make them available through GEANT-compliant federated and distributed AA policies, guaranteeing transparency and trust in the provisioning of such services.

INDIGO will also address the development of a flexible and modular presentation layer connected to the expanded PaaS and SaaS frameworks developed by the project and allowing innovative user experiences, also from mobile appliances.";11565239;11138114;H2020-EINFRA-2014-2;RIA;ISTITUTO NAZIONALE DI FISICA NUCLEARE;IT;"ISTITUTO NAZIONALE DI GEOFISICA E VULCANOLOGIA;T-SYSTEMS INTERNATIONAL GMBH;AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE;CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE;LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY;UNIVERSITEIT UTRECHT;STICHTING EGI;Istituto Centrale per il Catalogo Unico delle biblioteche italiane e per le informazioni bibliografiche;INDRA SISTEMAS SA;INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;CONSIGLIO NAZIONALE DELLE RICERCHE;KARLSRUHER INSTITUT FUER TECHNOLOGIE;RUDER BOSKOVIC INSTITUTE;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;ISTITUTO NAZIONALE DI ASTROFISICA;SANTER REPLY SPA;ATOS SPAIN SA;UNIVERSITAT POLITECNICA DE VALENCIA;FONDAZIONE CENTRO EURO-MEDITERRANEO SUI CAMBIAMENTI CLIMATICI;CESNET ZAJMOVE SDRUZENI PRAVNICKYCH OSOB";"IT;DE;PL;PT;ES;FR;UK;NL;HR;CH;CZ"; 194855;653371;IECEU;SIGNED;H2020-EU.3.7.;BES-12-2014;H2020;Improving the Effectiveness of the Capabilities (IEC) in EU conflict prevention;1/05/2015;31/01/2018;;"The European Union (EU) is increasingly affected and challenged by geopolitical changes, increasing impact of conflict on civilians, globalized impact of local conflicts, technological developments and budgetary constraints challenges the Radicalization, the growing potential for individuals to create large security threats and transnational criminality further complicates the security landscape of EU missions. With global interconnectedness, the repercussions of outside conflict are also seen within the EU, and may lead to societal and security challenges within the EU. The key issue for the EU is how to improve its conflict response capabilities to create more lasting impact on the ground and to use limited resources more effectively. Comprehensive EU-security within the EU emphasizes the need for civil-military synergies, which correspond more closely to challenges on the ground and the incorporation of very different perspectives, priorities and operational cultures.
The IECEUproject analyses and assesses best practices and lessons learned with a view to enhance the civilian conflict prevention and peace building capabilities of EU with a catalogue of practices, new solutions and approaches. It will seek to find out how to increase the interoperability of resources in the crisis management and peace building and what the potential for pooling and sharing of EU capabilities and technologies is. The main goals of the IECEU -project are:
1) Analysing and assessing the current situation of on-going and past missions and operations
2) Learning from lessons provided by these missions and assessing the different options
3) Providing new solutions, approaches and recommendations for EU to guarantee long-term stability";2081110;2081110;H2020-BES-2014;CSA;LAUREA-AMMATTIKORKEAKOULU OY;FI;"NATIONAL DEFENCE UNIVERSITY;NATIONAL UNIVERSITY OF IRELAND MAYNOOTH;TOUSSAINT MASCIA DIANA;ROSKILDE UNIVERSITET;PELASTUSOPISTO;UNIVERZA V LJUBLJANI;USTANOVA-CENTER ZA EVROPSKO PRIHODNOST;AUSTRIA INSTITUT FUR EUROPA- UND SICHERHEITSPOLITIK (AIES);SAFERGLOBE FINLAND RY;FORSVARET OG FORSVARSMINISTERIETS STYRELSER";"FI;IE;NL;DK;SI;AT"; 194809;652690;COLUMBUS;SIGNED;H2020-EU.3.2.;BG-11-2014;H2020;COLUMBUS - Monitoring, Managing and Transferring Marine and Maritime Knowledge for Sustainable Blue Growth;1/03/2015;28/02/2018;;"We are standing at the dawn of a century that will be largely affected by how we as a society are able to manage our oceans and their resources. Marine and Maritime Research has a critical role to play in developing our understanding of the seas and advance technology so that we can develop their economic potential in a sustainable manner.

The COLUMBUS project intends to capitalise on the ECs significant research by ensuring accessibility and uptake of research Knowledge Outputs by end-users (policy, industry, science and wider society). COLUMBUS will ensure measurable value creation from research investments contributing to sustainable Blue Growth within the timeframe of the project.

Adopting proven methodologies and building on significant past work, COLUMBUS will first identify end-user needs and priorities. It will then set about identifying and collecting Knowledge Outputs from past and current EC projects. Rigorous analysis will take place to identify specific applications and end-users. Transfer will be achieved and measured through tailor-made knowledge transfer. All knowledge collected will be made accessible the pre-existing Marine Knowledge Gate.
To achieve the above, COLUMBUS has brought together a multi-disciplinary, multi-stakeholder team representing all aspects of the research value chain from funding agencies to end-users. Key strategic initiatives and networks further strengthen and provide a strong vehicle for project legacy. A network of 9 Competence Nodes, each with a Knowledge Fellow and support team across Europe will provide the necessary critical mass (470pm of effort) to ensure full thematic and spatial coverage.
COLUMBUS will also carry out strategic actions to enhance the visibility and impact of research to stakeholders and European Citizens. Furthermore working with funding agencies and stakeholders, COLUMBUS will examine the feasibility of improved systems and processes to ensure measurable value creation from research.";3997488;3997488;H2020-BG-2014-1;CSA;BORD IASCAIGH MHARA;IE;"EUROGOOS AISBL;AquaTT UETP Ltd;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;INTERNATIONAL COUNCIL FOR THE EXPLORATION OF THE SEA;Europas Maritime Udviklingscenter;THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS;VLAAMS INSTITUUT VOOR DE ZEE VZW;FORSCHUNGSZENTRUM JULICH GMBH;EUROPEAN AQUACULTURE SOCIETY;SMARTBAY IRELAND LIMITED;FUNDACAO EUROCEAN;MARINE SOUTH EAST;PANAGIOTIS CHRISTOFILOGIANNIS - IOANA TAVLA;European Council for Maritime Applied R&D Association;DANMARKS TEKNISKE UNIVERSITET;CENTER OF MARITIME TECHNOLOGIES EV;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;SEASCAPE CONSULTANTS LTD;CONSORCIO PARA EL DISENO, CONSTRUCCION, EQUIPAMIENTO Y EXPLOTACION DE LA PLATAFORMA OCEANICA DE CANARIAS;AQUATERA LIMITED;SOCIETE D'EXPLOITATION DU CENTRE NATIONAL DE LA MER;NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU;SOCIEDAD PARA EL FOMENTO DE LA INNOVACION TECNOLOGICA S.L. - INNOVATEC;CENTRO TECNOLOGICO DEL MAR - FUNDACION CETMAR;NATURAL ENVIRONMENT RESEARCH COUNCIL";"BE;IE;FR;DK;UK;DE;PT;EL;RO;ES;NO"; 194909;653926;WEEVIL;SIGNED;H2020-EU.3.4.;GV-5-2014;H2020;Ultralight and ultrasafe adaptable 3-wheeler;1/06/2015;31/05/2019;;"L category vehicles should answer the demands for less energy consumption and affordability and represent an attractive solution in congested cities with scarce parking space. WEEVIL aims to develop a new L category 3-wheeler that is quiet, clean, energy efficient and safe, as well as attractive to the public so that the barriers for adopting it are minimized.
The new vehicle concept is an ultralight and ultrasafe adaptable 3-wheeler, with a composite structure using new manufacturing processes for an affordable introduction of these materials in new vehicles. Modularity of elements (including battery packs), system integration and innovative vehicle architecture is considered in the vehicle design. The vehicle has a wheel width varying mechanism in order to allow adaptation to different speeds (wider at high speeds for stability, narrower at low speeds for space optimization and parking).
WEEVIL will provide a new electric vehicle concept with innovative design to allow the user to adapt the vehicle to higher speeds or lower speeds and/or parking. Its characteristics will be lightness and safety, with a strong use of composite materials through new and affordable processing methods. A new drive-train with improved energy efficiency will be incorporated, as well as new solutions on system integration such as modular battery packs.
WEEVIL solution will break the barriers for extended EV adoption in urban areas, i.e. vehicle capabilities and cost trade-off. A car-like comfort and driving experience in a reduced space (2-3 wheeler vehicle) is pursued.
By providing a feasible concept adapted to the users expectations, the European EV car pool would be significantly enlarged, providing the pursued benefits on air quality, noise and environmental protection and also bringing traffic congestion reductions and a potential dominance of the European industry in this market.";6293944;6293944;H2020-GV-2014;RIA;FUNDACION TEKNIKER;ES;"RPH S.R.L.;AUTOMON S. COOP;HEKSAGON MUHENDISLIK VE TASARIM AS;COMARTH ENGINEERING SL;Przemyslowy Instytut Motoryzacji;IADA SRL ISTITUTO ARTE E DESIGN APPLICATI;KAITEK SRL;MONDRAGON AUTOMOCION S COOP;FAGOR AUTOMATION S COOP LTDA;INDUSTRIAS QUIMICAS IRURENA SA";"IT;ES;TR;PL"; 194803;652643;Respon-SEA-ble;SIGNED;H2020-EU.3.2.;BG-13-2014;H2020;Sustainable oceans : our collective responsibility, our common interest. Building on real-life knowledge knowledge systems for developing interactive and mutual learning media;1/04/2015;31/03/2019;;"The project will develop well-targeted and sound communication material that raises awareness on our (individual and collective) responsibility and interest in ensuring the sustainability of the ocean and of its ecosystems. The project builds on critical assessments of: (1) existing communication strategies, material and governance that focuses on the ocean; (2) the values, perceptions and understanding of the state, functioning and role of the ocean by different types of stakeholders and of the wider public; (3) the (scientific) knowledge that exist on the ocean-human relationship, in particular in terms of ecosystem services that can be delivered by ocean ecosystems and support (future) development opportunities and blue growth and of pressures that are imposed on the oceans. These critical assessments will help identifying priority target groups with key responsibilities and interests in the state of our oceans - today and in the future.

Within a participatory process involving the stakeholders of the knowledge creation & sharing system from four European marine regions (Baltic Sea, Mediterranean Sea, Northern Sea and Atlantic _ including in its transatlantic dimension), and building on the scientific knowledge-base established and on project-dedicated IT strucure/platform, the project will then develop and test under real conditions innovative communication tools. Key principles guiding this development will be interactivity, mutual learning, creativity and entertainment. Finally, specific activities will be performed for ensuring proposed communication tools are made accessible and available to their future users in Europe but also elswhere.";3696644;3696644;H2020-BG-2014-1;CSA;ACTEON SARL;FR;"COFAC COOPERATIVA DE FORMACAO E ANIMACAO CULTURAL CRL;SEVEN ENGINEERING CONSULTANTS OE;STIFTELSEN GRID ARENDAL;CSP - INNOVAZIONE NELLE ICT S.C.A.R.L.;UNIVERSITY OF PLYMOUTH;NATIONAL UNIVERSITY OF IRELAND, GALWAY;NORSK INSTITUTT FOR VANNFORSKNING;UNIVERSITE DE BRETAGNE OCCIDENTALE;TELEVISION FOR THE ENVIRONMENT;FUNDACION AZTI - AZTI FUNDAZIOA;BALTIC ENVIRONMENTAL FORUM DEUTSCHLAND EV;THE MARINE FOUNDATION LIMITED;STICHTING PROSEA MARINE EDUCATION;INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE DELTA DUNARII";"PT;EL;NO;IT;UK;IE;FR;ES;DE;NL;RO"; 195183;655859;Voice Modulation;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Faking It: The production, perception, and function of social voice modulation;1/02/2016;31/01/2018;;"The human voice is a social tool. Non-linguistic voice cues can influence judgements of attractiveness, formidability, trustworthiness, intelligence, and general likeability, with meaningfully differential social outcomes depending on whether ones voice is credited, unduly or not, with positive or negative attributes. Yet, despite its apparent societal implications and the known capacity for vocal control, studies of human voice perception have focused on static rather than dynamic speech. The proposed project will explore the vastly understudied niche of human voice modulation. The Research Objectives of the project are to: (1) Provide the first experimental evidence of voice modulation in four novel social contexts (political debate, commercial ad, public lecture, and first date); (2) Describe the structure and production mechanisms of modulated speech using new technology developed through a secondment; (3) Identify individual and environmental factors that affect the use and nature of modulated speech; (4) Test the extent to which voice modulation effectively influences social attributions and decisions. The project will be the first to examine voice modulation across cultures, addressing a serious need for comparative research in psychology, and facilitating international collaboration. The research objectives will be achieved through a unique combination of lab and field voice recordings, spectrotemporal speech analysis, questionnaire data, cross-cultural and cross-linguistic playback experiments, and sophisticated statistical modelling. This original line of research will provide ample insight into how the voice affects human behaviour, ultimately helping to uncover the functions and origins of nonverbal communication, but also educating lay and scientific communities about social stereotyping and its socioeconomic impact. Importantly, the Fellowship will put me in an excellent position to secure a research station in one of the top European universities.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF SUSSEX;UK;;; 194884;653586;SpeechXRays;SIGNED;H2020-EU.3.7.;DS-02-2014;H2020;Multi-channel biometrics combining acoustic and machine vision analysis of speech, lip movement and face;1/05/2015;30/04/2018;;"The SpeechXRays project will develop and test in real-life environments a user recognition platform based on voice acoustics analysis and audio-visual identity verification. SpeechXRays will outperform state-of-the-art solutions in the following areas:
Security: high accuracy solution (cross over accuracy1 of 1/100 ie twice the commercial voice/face solutions)
Privacy: biometric data stored in the device (or in a private cloud under the responsibility of the data subject)
Usability: text-independent speaker identification (no pass phrase), low sensitivity to surrounding noise
Cost-efficiency: use of standard embedded microphone and cameras (smartphones, laptops)
The project will combine and pilot two proven techniques: acoustic driven voice recognition (using acoustic rather than statistical only models) and multi-channel biometrics incorporating dynamic face recognition (machine vision analysis of speech, lip movement and face).
The vision of the SpeechXRays project is to provide a solution combining the convenience and cost-effectiveness of voice biometrics, achieving better accuracies by combining it with video, and bringing superior anti-spoofing capabilities.
The technology will be deployed on 2000 users in 3 pilots: a workforce use case, an eHealth use case and a consumer use case.
The project lasts 36 months and is coordinated by world leader in digital security solutions for the mobility space.";5343606,25;4102467;H2020-DS-2014-1;IA;OBERTHUR TECHNOLOGIES SA;FR;"HOROWITZ BIOMETRICS LIMITED;REALEYES OU;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;ELLINIKI ETAIRIA TILEPIKOINONION KAI TILEMATIKON EFARMOGON AE;TECH INSPIRE LTD;INSTITUT MINES-TELECOM;UNIVERSITY COLLEGE LONDON;SIVECO ROMANIA SA;INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA ""HORIA HULUBEI"" (IFIN-HH)";"UK;EE;EL;FR;RO"; 194906;653879;FLYSEC;SIGNED;H2020-EU.3.7.;DRS-16-2014;H2020;Optimising time-to-FLY and enhancing airport SECurity;1/05/2015;30/04/2018;;"Complementing the ACI/IATA efforts, FLYSEC project aims to develop and demonstrate an innovative integrated and end-to-end airport security process for passengers, enabling a guided and streamlined procedure from the landside to airside and into the boarding gates, and offering for the first time an operationally validated innovative concept for end-to-end aviation security.

On the technical side, FLYSEC achieves its ambitious goals by integrating new technologies on video surveillance, intelligent remote image processing and biometrics combined with big data analysis, open-source intelligence and crowdsourcing. Repurposing existing technologies is also in the FLYSEC objectives, such as mobile application technologies for improved passenger experience and positive boarding applications (i.e. services to facilitate boarding and landside/airside wayfinding) as well as RFID for carry-on luggage tracking and quick unattended luggage handling. Besides more efficient background checks and passenger profiling, FLYSEC aims to implement a seamless risk-based security process within FLYSEC combining the aforementioned technologies with behavioural analysis and innovative cognitive algorithms. A key aspect in the design of FLYSEC risk-based security is applying ethical-by-design patterns, maximizing the efficiency of security controls through passenger differentiation ranging from unknown to trusted, while remaining ethical and fair in the process. Policy, regulatory and standardisation aspects will also be examined in the context of FLYSEC innovative security concept.";4141375;4089500;H2020-DRS-2014;RIA;"""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS""""""";EL;"ICTS (UK) LTD;UNIVERSITE DU LUXEMBOURG;EPSILON INTERNASIONAL ANONYMI ETAIREIA MELETON KAI SYMVOULON (EPSILON INTERNATIONAL SA);CG SMARTECH LTD;EXODUS ANONYMOS ETAIREIA PLIROFORIKIS;EMZA VISUAL SENSE LTD;EASC EV;ELBIT SYSTEMS LTD;EMBRY-RIDDLE AERONAUTICAL DEUTSCHLAND GMBH;SOCIETE DE L AEROPORT DE LUXEMBOURG SA";"UK;LU;EL;IL;DE"; 194815;652796;EuroStemCell;SIGNED;H2020-EU.3.1.;Health;H2020;European Consortium for Communicating Stem Cell Research;1/01/2015;31/03/2018;;The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Information Portal www.eurostemcell.org. To achieve our aims, EuroStemCell will adopt the highly structured system for coordinated information management established by the FP7 Coordination and Support Action (CSA) also called EuroStemCell. From this, we will implement an ambitious programme of online and direct stakeholder engagement with stem cell research and regenerative medicine, aimed at European citizens at all educational levels. This will include provision of resources tailored specifically for decision-making on stem cell-related questions and an extensive programme of dissemination and capacity building in science communications and public engagement. The proposed work centres on an information hub team, which will link to all project partners and to stakeholders in the stem cell and regenerative medicine arenas and wider society, working with these groupings to implement the project. All outputs will be delivered in 6 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading stem cell labs across Europe, including new member states, together with experts in ethical and societal concerns and evaluating clinical outcomes. It thus provides unparalleled European expertise across the fields of stem cell biology and regenerative medicine and is uniquely placed to maintain and further develop www.eurostemcell.org as a world-leading stem cell information resource, thus meeting the challenge outlined in Topic HOA-6-2014.;2251193,23;600000;H2020-Adhoc-2014-20;CSA;THE UNIVERSITY OF EDINBURGH;UK;"UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA;UNIWERSYTET WARSZAWSKI;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;FUNDACIO CENTRE DE REGULACIO GENOMICA;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;Masarykova univerzita;THE UNIVERSITY OF MANCHESTER;INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH;VRIJE UNIVERSITEIT BRUSSEL;ACADEMISCH ZIEKENHUIS LEIDEN;KOBENHAVNS UNIVERSITET;UNIVERSITA DEGLI STUDI DI MILANO;GERMAN STEMCELL NETWORK (GSCN) - DEUTSCHES STAMMZELLNETZWERK EV;NATIONAL UNIVERSITY OF IRELAND, GALWAY;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;UNIVERSITE LIBRE DE BRUXELLES;THE UNIVERSITY OF BIRMINGHAM;SZENT ISTVAN UNIVERSITY;ISTITUTO EUROPEO DI ONCOLOGIA SRL;KAROLINSKA INSTITUTET;ACADEMISCH ZIEKENHUIS GRONINGEN;THE UNIVERSITY OF SHEFFIELD;LUNDS UNIVERSITET;ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK;CARDIFF UNIVERSITY;University of York;INSTITUT PASTEUR;LIFE AND BRAIN GMBH;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA;KING'S COLLEGE LONDON";"IT;PL;UK;ES;NL;CZ;AT;BE;DK;DE;IE;CH;HU;SE;FR"; 194871;653468;ECOCHAMPS;SIGNED;H2020-EU.3.4.;GV-4-2014;H2020;European COmpetitiveness in Commercial Hybrid and AutoMotive PowertrainS;1/05/2015;30/04/2018;;The ECOCHAMPS project addresses topic GV-4-2014, Hybrid Light and Heavy Duty Vehicles. The work will, in a single coordinated project, address all aspects of this topic and will be conducted by 26 partners representing the European automotive industry (OEMs (EUCAR), suppliers (CLEPA), ESPs and universities (EARPA)) including members of ERTRAC and EGVIA. The objective is to achieve efficient, compact, low weight, robust and cost effective hybrid powertrains for both passenger cars and commercial vehicles (buses, medium and heavy duty trucks) with increased functionality, improved performance, comfort, safety and emissions below Euro 6 or VI, all proven under real driving conditions. The five demonstrator vehicles, for this purpose developed to TRL 7, that use the hybrid powertrains will among other give a direct cost versus performance comparison at two system voltage levels in the light duty vehicles, and include the modular and standardized framework components in the heavy duty vehicles. Achieving these innovations affordably will strengthen technical leadership in powertrains, enable a leading position in hybrid technology and increases the competitiveness of European OEMs. The vehicles will be ready for market introduction between 2020 and 2022 and (price) competitive to the best in-class (full hybrid) vehicles on the market in 2013. More importantly, the technology devised will impact on the reduction of CO2 emissions and the improvement of air quality. The project proposes to reach a 20% powertrain efficiency improvement and a 20% powertrain weight and volume reduction, with a 10% cost premium on the base model for the demonstrator. To meet air quality targets the project will prove, via independently supervised testing, real driving emissions at least below Euro 6 or VI limits and by simulation show the potential of the passenger car technologies to reach Super Low Emission Vehicle standards.;28419785,01;21009064,67;H2020-GV-2014;IA;DAF Trucks NV;NL;"Engineering Center Steyr G.m.b.H. & Co KG;ZF FRIEDRICHSHAFEN AG;SAMSUNG SDI BATTERY SYSTEMS GMBH;DAIMLER AG;Robert BOSCH GMBH;CENTRO RICERCHE FIAT SCPA;AVL LIST GMBH;FEV EUROPE GMBH;IVECO S.p.A.;RICARDO UK LIMITED;FUNDACION TECNALIA RESEARCH & INNOVATION;GKN DRIVELINE INTERNATIONAL GMBH;JOHNSON MATTHEY BATTERY SYSTEMS ENGINEERING LIMITED;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;EUROPEAN THERMODYNAMICS LIMITED;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;GEVEKE WERKTUIGBOUW BV;Kompetenzzentrum - Das Virtuelle Fahrzeug, Forschungsgesellschaft mbH;FPT INDUSTRIAL;RENAULT SAS;UNIRESEARCH BV;GARDNER DENVER LIMITED;TECHNISCHE UNIVERSITEIT EINDHOVEN;QUEEN MARY UNIVERSITY OF LONDON;MAN TRUCK & BUS AG;MAGNA STEYR BATTERY SYSTEMS GMBH & CO OG;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"AT;DE;IT;UK;ES;NL;FR;BE"; 194937;654142;EGI-Engage;SIGNED;H2020-EU.1.4.1.3.;EINFRA-1-2014;H2020;Engaging the EGI Community towards an Open Science Commons;1/03/2015;31/08/2017;;"Over the last decade, the European Grid Infrastructure (EGI) has built a distributed computing and data infrastructure to support over 21,000 researchers from many disciplines with unprecedented data analysis capabilities. EGI builds on the European and national investments and relies on the expertise of EGI.eu - a not-for-profit foundation that provides coordination to the EGI Community, including user groups, EGI.eu participants in the EGI Council, and the other collaborating partners.

The mission of EGI-Engage is to accelerate the implementation of the Open Science Commons vision, where researchers from all disciplines have easy and open access to the innovative digital services, data, knowledge and expertise they need for their work. The Open Science Commons is grounded on three pillars: the e-Infrastructure Commons, an ecosystem of key services; the Open Data Commons, where any researcher can access, use and reuse data; and the Knowledge Commons, in which communities have shared ownership of knowledge and participate in the co-development of software and are technically supported to exploit state-of-the-art digital services.

EGI-Engage will expand the capabilities offered to scientists (e.g. improved cloud or data services) and the spectrum of its user base by engaging with large Research Infrastructures (RIs), the long-tail of science and industry/SMEs. The main engagement instrument will be a network of eight Competence Centres, where National Grid Initiatives (NGIs), user communities, technology and service providers will join forces to collect requirements, integrate community-specific applications into state-of-the-art services, foster interoperability across e-Infrastructures, and evolve services through a user-centric development model. The project will also coordinate the NGI efforts to support the long-tail of science by developing ad hoc access policies and by providing services and resources that will lower barriers and learning curves.";8650001,5;8000000;H2020-EINFRA-2014-2;RIA;STICHTING EGI;NL;"AGRO-KNOW IKE;ENGINEERING - INGEGNERIA INFORMATICA SPA;EUROPEAN MOLECULAR BIOLOGY LABORATORY;FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS FAO;AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE;CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE;PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI;MAAT FRANCE SARL;USTAV INFORMATIKY, SLOVENSKA AKADEMIA VIED;VLAAMS INSTITUUT VOOR DE ZEE VZW;LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS;ISTITUTO NAZIONALE DI FISICA NUCLEARE;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY;ICETA INSTITUTO DE CIENCIAS, TECNOLOGIAS E AGROAMBIENTE DA UNIVERSIDADE DO PORTO;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;Uppsala universitet;Biobanking and Biomolecular Resources Research Infrastructure - European Research Infrastructure Consortium;GESELLSCHAFT FUR WISSENSCHAFTLICHE DATENVERARBEITUNG MBH GOTTINGEN;EISCAT SCIENTIFIC ASSOCIATION;ADVANCED SCIENCE AND TECHNOLOGY INSTITUTE;THE TRUSTEES OF INDIANA UNIVERSITY;SURFSARA BV;INSTITUT TEKNOLOGI BANDUNG BHMN;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;UNIVERSITI PUTRA MALAYSIA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;SWISS NATIONAL GRID ASSOCIATION (SWING);CONSIGLIO NAZIONALE DELLE RICERCHE;MAGYAR TUDOMANYOS AKADEMIA SZAMITASTECHNIKAI ES AUTOMATIZALASI KUTATOINTEZET;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;INSTITUTE OF INFORMATION AND COMMUNICATION TECHNOLOGIES;SVEUCILISTE U ZAGREBU SVEUCILISNI RACUNSKI CENTAR;ACADEMIA SINICA;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN;CESNET ZAJMOVE SDRUZENI PRAVNICKYCH OSOB;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE";"EL;IT;DE;PL;FR;SK;BE;PT;ES;FI;UK;SE;AT;PH;US;NL;ID;MY;CH;HU;BG;HR;TW;TR;CZ"; 194840;653241;OMNICS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Observing, Modelling and Predicting in situ Petrophysical Parameter Evolution in a Geologic Carbon Storage System;10/03/2016;9/03/2018;;Geologic Carbon Storage (GCS) is a promising remedial activity that society can use to tackle imminent problems from increased atmospheric CO2 and climate change. The fate and transport of the stored CO2 are controlled by a storage formations petrophysical parameters, which evolve rapidly after the CO2 injection because of geochemical reactions. Knowing how the pore structure evolves is critical to the safe and effective implementation of GCS because it affects the sealing integrity, injectivity and storage capacity of a geologic site. How such evolution can be quantified is still unknown, because of the technological difficulties in direct observation within pores and the high computational cost required to predict such evolution based on current modelling approaches. My project will pioneer the study of GCS-related petrophysical parameter evolution by combining synchrotron based nanotomography with a highly customizable reactor network model. Tomography enables the in situ observation of the porous medias morphological evolution that leads to petrophysical property changes. The reactor network model can significantly reduce computational costs for predicting parameter evolution. OMNICS builds on a combination of my expertise in GCS-related research and chemical reactor design with my hosts world leading nanostructure characterization facilities and cutting edge interdisciplinary research profile. Strong industry links provided by my host means that my new prediction technique will provide direct guidance for site selection, risk assessment and injection management, pushing the technological readiness level of GCS from applied research towards market relevant implementation as a technical support service. Meanwhile, the training, mentoring and support offered by my advisor, Prof. S. Stipp, will broaden my expertise, sharpen my competences and extend my research network, which will help me secure a academic position in Europe by fully realizing my potential.;200194,8;200194,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KOBENHAVNS UNIVERSITET;DK;;; 195168;655770;CONSCRISIS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Households Consumption during the Great Recession: A structural analysis on the role of expectations;1/11/2015;31/10/2017;;"A striking feature of the Great Recession is the fall in households expenditure and its slow recovery. The extraordinary duration of this contraction with respect to previous recessions stimulated the interest of scholars and policymakers in the analysis of its causes. In the early part of the crisis it is partly explained by a sudden crash in asset values. More recently, the decline in consumer confidence in several European countries is likely to have played a major role. This project aims to explore which factors explain why consumption has moved following the crisis and to assess the relevance of downwards revisions of income expectations.
Households who experience a deep and prolonged period of economic downturn, such as the Great Recession, may become increasingly convinced about the permanence of income shocks over time. Gradual downwards revisions of expectations about permanent income are likely to lead to a series of downwards adjustments in consumption spending. This project will exploit a structural approach that will enable me to investigate the relevance for consumption of this process of adjustment.
The contribution of this proposal is threefold. First, it improves the understanding of households consumption choices by analysing the role of income expectations. Second, it adds to the literature that investigates the determinants of the recession. The third contribution is methodological. An integral part of the project will be the elaboration and numerical solution of a lifecycle consumption-savings model with the novel feature that agents cannot (fully) observe the nature of the income shock and, thus, need time to learn about its permanence. The relevance of this proposal in a European perspective is enhanced by the cross-country perspective of the empirical analysis.
The outstanding experts in Econometrics, Economics of Consumption and, more precisely, in the use of structural models, make UCL the perfect environment to carry out this project.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 194904;653866;WOSCAP;SIGNED;H2020-EU.3.7.;BES-12-2014;H2020;Whole-of-Society Conflict Prevention and Peacebuilding;1/06/2015;30/11/2017;;This proposal seeks to enhance the capabilities of the EU for implementing conflict prevention and peacebuilding interventions through sustainable, comprehensive and innovative civilian means. It intends to address some of the dilemmas and paradoxes of external interventions that aim for local ownership in third countries, by exploring principles, processes and tools that can enhance EU capabilities. This will be achieved through the projects Review, Reflect, Recommend and Innovate objectives. Review will assess past and ongoing conflict prevention and peacebuilding initiatives of the EU and its partners, focusing on three types of EU interventions: multi-track diplomacy, security sector reform, and governance reform. The assessment will be based on field research in Georgia, Mali, Ukraine and Yemen, and desk reviews looking beyond these countries. Reflect will create a community of practice providing forums for dialogue that will bring together policymakers, civilian and military practitioners, academic experts and beneficiaries of EU interventions. These will validate and apply the evidence base by focusing on cross-cutting themes: local ownership, gender, multi-stakeholder coherence, civil-military synergies and ICTs. Recommend will elaborate the project findings into a tailored set of recommendations and enhance their impact through direct policy engagement and an international dissemination strategy. Innovate will contribute significantly to civilian conflict prevention and peacebuilding by identifying research priorities and tools, and enhancing the potential of ICTs. The project Whole-of-Society Approach to Conflict Prevention and Peacebuilding is a conscious attempt to address the relationships of peacebuilding actors within a wider cultural and institutional context. It deals with issues of coordination, synergies and inclusivity of peacebuilding efforts, where diverse stakeholders have a role to play in the process.;2018034,75;1990114,25;H2020-BES-2014;CSA;STICHTING GLOBAL PARTNERSHIP FOR THE PREVENTION OF ARMED CONFLICT;NL;"BERGHOF FOUNDATION OPERATIONS GMBH;INSTITUT SVITOVOI POLITIKI;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;POLITICAL DEVELOPMENT FORUM;UNIVERSITE DES SCIENCES JURIDIQUES ET POLITIQUES DE BAMAKO;UNIVERSITEIT UTRECHT;ASSOCIATION GROUPE ESSEC;UNIVERSITAT AUTONOMA DE BARCELONA;IVANE JAVAKHISHVILI TBILISI STATE UNIVERSITY";"DE;UA;UK;YE;ML;NL;FR;ES;GE"; 194985;654719;lincPeptEvolDev;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;LincRNA and encoded small peptides: Functional discovery in development and evolution;1/05/2015;30/04/2017;;Beyond the paradigm of the central dogma of biology lie a number of recently discovered elements that are nonetheless central to cellular function. Eukaryotic genomes express an unexpectedly wide variety of functional long transcripts that do not encode major proteins, called long non-coding RNAs (lncRNAs), whose functions are still poorly understood. More recent work has uncovered the prevalence of small open reading frames (smORFs) encoded within both mRNA and lncRNAs, only a few of which have evidence of active translation and function. The work in this proposal focuses on these relatively uncharacterized layers of biological regulation, and aims to harness the power of insect developmental genetics and the exquisite knowledge of axial patterning in embryos to probe the function of small peptides/lncRNA. Developmental gene networks in insects with varied modes of development have been studied in detail, allowing insights into how such networks have evolved. I will use a combination of state-of-the-art comparative genomics and transcriptome analysis, molecular genetics, biochemistry, and ribosome profiling to identify transcripts encoding putative small peptides with conserved features across insects, which represent novel components of developmental networks. This will be accompanied by genetic studies illuminating their functional interactions within developmental networks, including embryonic expression and loss of function phenotypes. Our approach to studying small peptides includes creation of innovative functional assays needed in the field, and is relevant to understanding the function of small peptides in all animals.;182509,2;182509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;WEIZMANN INSTITUTE OF SCIENCE;IL;;; 194789;652612;FACCE-Evolve;SIGNED;H2020-EU.3.2.;ISIB-11-2014;H2020;FACCE-Evolve - Agriculture, Food Security and Climate Change Coordination and Support Action 2;1/03/2015;29/02/2020;;"The Joint Programming Initiative on Agriculture, Food Security and Climate Change (FACCE-JPI), launched in October 2010 by the European Council, brings together 21 countries committed to building an integrated European Research Area addressing the challenges of agriculture, food security and climate change (FACCE-JPI Strategic Research Agenda). The JPI aims at aligning research programming among its members in the long run, so as to increase the efficiency of research funding, cover gaps, avoid duplications and provide high-level innovative research on the European scene.
The FACCE-Evolve Coordination and Support Action is designed to solidify foundations that will ensure long-term durability of joint programming and actions. FACCE-Evolve will thus continue to support the successful development of the FACCE-JPI and allow it to develop a set of means destined to ensure its self-sustainability. The FACCE-Evolve will therefore provide support to JPI members in order to:
Investigate different options for self-sustainability and test the most suitable ones.
Investigate and develop novel processes and tools to support uptake of the SRA and its updates as well as the bi-annual implementation plans and monitor effective harmonisation, integration and alignment of national research programming, to enable evidence-based policy making and effective cross-policy actions
Implement and oversee the increasing number of joint actions
Pursue ongoing coordination with Horizon 2020 objectives with a scale and scope of action that should go well beyond what either the EU or Member States can achieve on their own
Ensure the perpetuation of an effective, enriching dialogue with European and international stakeholders
Strengthen the international dimension and visibility of the JPI through a strong communication and dissemination strategy and links with other initiatives.";3354625;2000000;H2020-ISIB-2014-1;CSA;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;"Bundesanstalt fr Landwirtschaft und Ernhrung;MINISTERO DELLE POLITICHE AGRICOLE ALIMENTARI E FORESTALI;LUONNONVARAKESKUS;FORSCHUNGSZENTRUM JULICH GMBH;BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL;INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA;INNOVATIONSFONDEN;INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE;STICHTING WAGENINGEN RESEARCH";"DE;IT;FI;UK;ES;DK;RO;NL"; 194800;652638;Hennovation;SIGNED;H2020-EU.3.2.;ISIB-02-2014;H2020;Practice-led innovation supported by science and market-driven actors in the laying hen and other livestock sectors;1/01/2015;31/08/2017;;"Using the laying hen sector as a case study, we aim to demonstrate the potential for practice-driven innovation networks, supported by existing science and market-driven actors, to develop practical cost-effective solutions to sustainability challenges (objective 1). Multi-stakeholder networks will develop technical innovations to injurious pecking and the management of end-of-lay hens concerns based on practice, economics and scientific information (objective 2). A generic support package of communication web based tools, facilitation guides and on-line training programmes, designed to help science and market- driven actors, will then be available to support practice-driven innovation networks in other livestock sectors (objective 3). Finally we will develop policy recommendations that help realize the full potential of practice-driven innovation through multi stakeholder networks in livestock sectors (objective 4). This project will tackle four challenges associated with the need for grass-root innovation highlighted in the Horizon 2020 call; 1) legitimacy by robust practical and financial evaluation, 2) accessibility by communication between producers and existing innovation support actors, 3) connectivity by an industry-led dissemination strategy ensuring information about innovations are widely spread using existing communication tools and finally 4) sufficient resource by production of a support package and policy recommendations that facilitate better interaction of science-driven and practice-driven innovation. The success of this approach to the laying hen sector and other sectors will be evaluated by the ability of the network to encourage practice-led innovation, check the effectiveness of the innovation, ensure optimum use of scientific information, provide a route for traditional knowledge transfer when required, disseminate results of innovation to others and ensure that policy is informed by practice-led solutions.";2094055;2094055;H2020-ISIB-2014-1;CSA;UNIVERSITY OF BRISTOL;UK;"THE UNIVERSITY OF EXETER;SVERIGES LANTBRUKSUNIVERSITET;VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO;UNIVERSITAT AUTONOMA DE BARCELONA;ADAS UK LIMITED;STICHTING WAGENINGEN RESEARCH";"UK;SE;CZ;ES;NL"; 194891;653704;OPERANDO;SIGNED;H2020-EU.3.7.;DS-01-2014;H2020;Online Privacy Enforcement, Rights Assurance and Optimization;1/05/2015;30/04/2018;;"The goal of the OPERANDO project is to specify, implement, field-test, validate and exploit an innovative privacy enforcement platform that will enable the Privacy as a Service (PaS) business paradigm and the market for online privacy services.
The OPERANDO project will integrate and extend the state of the art to create a platform that will used by independent Privacy Service Providers (PSPs) to provide comprehensive user privacy enforcement in the form of a dedicated online service, called Privacy Authority. The OPERANDO platform will support flexible and viable business models, including targeting of individual market segments such as public administration, social networks and Internet of Things.
A key aspect addressed by OPERANDO is the need to simplify privacy for end users (data subjects). OPERANDO will support a simple Privacy Dashboard allowing users to specify their preferences. These will be automatically compared with Online Service Provider (OSP) privacy policies and translated into personal data access control decisions by the PSP.
OPERANDO will also address OSP requirements for simplified privacy compliance checking and auditing, to verify that they will meet user expectations or to satisfy privacy regulators. The technology will be trialled in the health care and public administration sectors.
The OPERANDO consortium thereby aims to contribute to the entire ecosystem of online privacy stakeholders: Users, PSPs, Online Service Providers and Regulators. Federation of Privacy Authorities will be supported to increase value of the services and their uptake. The OPERANDO platform will be positioned for endorsement by European governments and standardization bodies. To increase transparency of the privacy services and dissemination of results, OPERANDO outcomes will be implemented in Open Source, and will be made available to the community for evolution and value-adding beyond the scope of the project.";4455811,25;3746037;H2020-DS-2014-1;IA;OXFORD COMPUTER CONSULTANTS LIMITED;UK;"FUNDACION TECNALIA RESEARCH & INNOVATION;STELAR SECURITY TECHNOLOGY LAW RESEARCH UG;UNIVERSITY OF PIRAEUS RESEARCH CENTER;FONDAZIONE CENTRO SAN RAFFAELE;UNIVERSITY OF SOUTHAMPTON;PROGETTI D'IMPRESA SRL;ARTEEVO TECHNOLOGIES LTD;ROMSOFT SRL";"ES;DE;EL;IT;UK;IL;RO"; 194894;653739;SETRIS;SIGNED;H2020-EU.3.4.;MG-9.6-2014;H2020;Strengthening European Transport Research and Innovation Strategies;1/05/2015;30/04/2017;;"This proposal specifically addresses the topic MG.9.6-2014. Strengthening the research and innovation strategies of the transport industries in Europe.

The aim of SETRIS is to deliver a cohesive and coordinated approach to research and innovation strategies for all transport modes in Europe. To fulfil the aim of SETRIS, the following objectives are envisaged:
1. To identify synergies between the transport European Technology Platforms (ETPs) strategic and research and innovation agendas (SRIAs) and between these and relevant national platforms;
2. To review and update the existing SRIAs for each of the transport ETPs within a multi-modal and integrated transport system framework;
3. To benchmark past and present research initiatives affecting the achievement of integrated transport SRIAs and market uptake;
4. To define comprehensive, credible and realistic implementation plans for each SRIAs in a coordinated framework of running ETPs;
5. To support, shape and contribute to future TRA events.

Objectives 1-4 lead to two integrated agendas highlighting not only innovations or research activities that need to be done but also the changes in governance that are required to facilitate these Agendas.

These objectives will be implemented through the involvement, for the first time, of representatives of all relevant transport modes and European Technology Platforms within one single collaborative initiative. The ETPs will develop a framework for long-term cooperation between actors from all transport modes that will support the cohesive and coordinated approaches to research and innovation strategies that will facilitate the delivery of a truly integrated transport system.

The potential impact of SETRIS for the transport sector is extremely significant and the successful outcome of SETRIS is essential for Europes transport future. SETRIS will impact by defining comprehensive, credible and realistic implementation plans for joint SRIAs in a coordinated framework of running ETPs. This is a leap forward is cooperation between the ETPs and has been fully supported by the ETPs.";2999405;2999405;H2020-MG-2014_SingleStage_B;CSA;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;CENTRO NACIONAL DE COMPETENCIA EN LOGISTICA INTEGRAL;FORUM DES LABORATOIRES NATIONAUX EUROPEENS DE RECHERCHE ROUTIERE;AVL LIST GMBH;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;POLIS - PROMOTION OF OPERATIONAL LINKS WITH INTEGRATED SERVICES, ASSOCIATION INTERNATIONALE;INSTYTUT LOGISTYKI I MAGAZYNOWANIA;SHIPS AND MARITIME EQUIPMENT ASSOCIATION OF EUROPE ASBL;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;STICHTING DUTCH INSTITUTE FOR ADVANCED LOGISTICS;EUROCONTROL - EUROPEAN ORGANISATION FOR THE SAFETY OF AIR NAVIGATION;UNION DES INDUSTRIES FERROVIAIRES EUROPEENNES - UNIFE;UNION INTERNATIONALE DES CHEMINS DE FER;UNION INTERNATIONALE DES TRANSPORTS PUBLICS - UITP;ALLIANCE FOR LOGISTICS INNOVATION THROUGH COLLABORATION IN EUROPE;European Conference of Transport Research Institutes;BMT GROUP LTD";"DE;ES;BE;AT;NL;PL;FR;UK"; 194788;652527;DIGISTONE P1;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Production and Market entry financing of Digital Concrete Screen for Outdoor Digital Signage application;1/10/2014;31/03/2015;;The DIGISTONE market phase 1 aims at adressing a major market opportunity in the supply of large, concrete multimedia displays primarily for outdoor digital signage and commercial applications.;71429;50000;H2020-SMEINST-1-2014;SME-1;DUPONT LIGHTSTONE APS;DK;;; 194866;653443;FUDOGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Will this fire burn out? The topos of lovers' separation in the Italian Renaissance;1/09/2015;31/08/2017;;"The project aims to achieve the first in-depth study on the lyrical topos of lovers separation (i.e. when a lover has to go away and therefore leaves her/his beloved for some time) in the Italian Renaissance. The study is meant to improve our knowledge about: 1) the different ways to read and re-use the tradition in the Renaissance; 2) the role of Petrarch as an authority in Renaissance love literature, also in comparison to other models; 3) the interaction between lyrics and love treatises, as well as between literature and philosophy in the conception and representation of love in the Renaissance. For such a goal, Dr. Favaro will analyze the topos of lovers separation in Renaissance lyrics and love treatises, paying attention to their mutual interaction, as well as to the relationship with the previous literary tradition and with philosophical sources (especially Neoplatonism). He will also achieve the commented editions of two little-known Renaissance dialogues entirely devoted to the subject of lovers separation.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FREIE UNIVERSITAET BERLIN;DE;;; 194962;654305;EuroCirCol;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-1-2014;H2020;European Circular Energy-Frontier Collider Study;1/06/2015;31/05/2019;;"The award of the 2013 Nobel Prize for Physics acknowledged the leading role of Europe in particle physics, which has a global community of over 10,000 scientists. To reinforce its pole position throughout the 21st century, Europe must be ready to propose an ambitious post-LHC accelerator project by 2018/19. This is one of the main recommendations of the updated European Strategy for Particle Physics, adopted by the CERN Council in May 2013.
The EuroCirCol conceptual design study is a direct response to this recommendation, initiating a study for a 100 TeV energy-frontier circular collider through a collaboration of institutes and universities worldwide.

A new research infrastructure of such scale depends on the feasibility of key technologies pushed beyond current state of the art. Innovative designs for accelerator magnets to achieve high-quality fields up to 16 T and for a cryogenic beam vacuum system to cope with unprecedented synchrotron light power are required. The effects of colliding two 50 TeV beams must be mastered to meet the physics research requirements. Advanced energy efficiency, reliability and cost effectiveness are key factors to build and operate such an accelerator within realistic time scale and cost.

This proposal is part of the Future Circular Collider study under European leadership, federating resources worldwide to assess the merits of different post-LHC accelerator scenarios. It forms the core of a globally coordinated strategy of converging activities, involving participants from the ERA and beyond. Organisations joining this study from Japan and the USA are expected to take part in a global implementation project and a suitable governance model will be drawn-up accordingly.

The main outcome of EuroCirCol will be laying the foundation of subsequent infrastructure development actions that will strengthen the ERA as a focal point of global research cooperation and as a leader in frontier knowledge and technologies over the next decades.";3989842;2999000;H2020-INFRADEV-1-2014-1;RIA;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;"CONSORCIO PARA LA CONSTRUCCION EQUIPAMIENTO Y EXPLOTACION DEL LABORATORIO DE LUZ SINCROTRON;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;ISTITUTO NAZIONALE DI FISICA NUCLEARE;CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS-CIEMAT;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;UNIVERSITEIT TWENTE;TTY-SAATIO;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;THE UNIVERSITY OF LIVERPOOL;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;KARLSRUHER INSTITUT FUER TECHNOLOGIE;TECHNISCHE UNIVERSITAT DARMSTADT;UNIVERSITE DE GENEVE;INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION, HIGH ENERGY ACCELERATOR RESEARCH ORGANISATION";"ES;UK;IT;FR;NL;FI;CH;DE;JP"; 194856;653373;SPICY;SIGNED;H2020-EU.3.4.;GV-1-2014;H2020;Silicon and polyanionic chemistries and architectures of Li-ion cell for high energy battery;1/05/2015;30/04/2018;;"SPICY is a collaborative research project associating 5 industrials partners (3 large groups and 2 SME) with 8 academic and research centres to the multidisciplinary development of a new generation of Li-ion batteries meeting the expectations of electrical vehicle end-users, including performances, safety, cost, recyclability and lifetime. For this purpose, SPICY will consider the development of new chemistry materials, cell architectures and packaging with the support of understanding and modelling activities. SPICY will address the whole value chain until the implementation of manufacturing.
SPICY will focus on polyanionic phosphates for the cathode material. LiFePO4 is well known as a safer and more durable cathode material. Unfortunately, its energy density is low due to the electrochemical potential of Fe. One objective of SPICY will be to bind metals having a higher potential than Fe, allowing an increase of the material potential, and thus a higher energy. Regarding the anode material, SPICY will study two chemistries. Graphite is used in current Li-ion cells and remains one of the major anode materials for the next generation of Li-ion cells. Silicon is appropriate for high energy cell applications but has lower cyclability. Silicon will be investigated through new synthesis process methods providing nanoparticles and core-shell structures to improve particle stability.
Active and passive components will be harmonized for a higher energy density i.e: polyanionic phosphate /graphite up to 200 Wh/kg, and polyanionic/Si up to 230 Wh/kg. In addition, three cells architectures and packaging will be investigated. The thermal behaviour of these cells will be studied in ageing tests in order to model Li-ion cells. Finally, the industrial environment will be considered and SPICY solution will be assessed so as to optimise cost and to integrate eco-design, thereby supporting the future development of a strong industrial base in this field.";7250428,75;6896053,5;H2020-GV-2014;RIA;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;"ASSOCIATION POLE EUROPEEN DE PLASTURGIE;FORSCHUNGSZENTRUM JULICH GMBH;BELIFE;TECHNISCHE UNIVERSITAET MUENCHEN;RECUPYL SAS;HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v.;PROLLION SAS;KARLSRUHER INSTITUT FUER TECHNOLOGIE;TEKNA PLASMA EUROPE;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.;FUNDACION CIDETEC;EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT;WAVESTONE LUXEMBOURG S.A.";"FR;DE;BE;ES;CH;LU"; 194922;654013;LoCO2Fe;SIGNED;H2020-EU.2.1.5.3.;SILC-II-2014;H2020;Development of a Low CO2 Iron and Steelmaking Integrated Process Route for a Sustainable European Steel Industry;1/05/2015;30/04/2018;;"Over the past decade, the steel industry in Europe has been spending a lot of effort in Research and Development of technologies that help in achieving the EUs CO2 emissions targets and reduce the cost of EU ETS compliance. That has been done through a combination of large scale projects which were part publicly funded with European funding and partly through smaller privately funded research activities.

From the initial stages of feasibility studies, several technologies were put forward for further development, one of which is the HIsarna smelting reduction process

The objective for the current proposal is to prove the capability of the HIsarna ironmaking technology to achieve at least 35% reduction in CO2 emission intensity, compared to blast furnace operated site based on Best Available Technology Currently Installed. This will be achieved through:

-Change operation parameters in order to achieve at least 35% CO2 intensity reduction per tonne of hot rolled coil compared to the conventional blast furnace BOF route through:
>Combined iron ore and scrap operation with a scrap rate of 350kg/thm;
>Partially replacing coal injection with sustainable biomass injection (at least 40%);
>Minimising coal rate by maximising energy use in the reactor, through balancing the energy between the upper and lower part of the reactor (<700 kg coal per tonne hot metal in pilot reactor);
>Using limestone instead of burnt lime as a fluxing agent;
>Quantifying potential for energy recovery from hot off-gas by installing boiler test panels;
>Making the process CCS ready by having process gas suitable for CCS with little or no processing by replacing compressed air and N2 carrier gasses with CO2 and CH4 as carrier gas;
-Operation of the HIsarna pilot plant for several months continuously in order to establish process and equipment stability;
-Test process conditions and validate for scale up to 0.8 Mtpa plant";14836830;7418415,02;H2020-SILC-II-2014;IA;TATA STEEL NEDERLAND TECHNOLOGY BV;NL;"THYSSENKRUPP STEEL EUROPE AG;TATA STEEL IJMUIDEN BV;ARCELORMITTAL MAIZIERES RESEARCH SA;VOESTALPINE STAHL GMBH;PAUL WURTH SA;TATA STEEL UK LIMITED";"DE;NL;FR;AT;LU;UK"; 195098;655374;ACCESS2WM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;How prior brain states govern access to working memory;1/09/2016;31/08/2018;;The ability to temporarily maintain and manipulate information in working memory (WM) is critical for adaptive behaviour. Because WM has limited capacity, it is essential to understand the mechanisms that govern selective access to it. I hypothesise that 1) selective access to WM is governed by states of the brain prior to the encoding and retrieval of sensory information (in particular the phase and amplitude of neural oscillations in the different sensory cortices), and that 2) changes in these states provide a common neural substrate through which several cognitive variables affect WM. I will use magneto-encephalography (MEG) to investigate several key aspects of these central hypotheses in healthy human volunteers. This will advance our understanding of the neural and cognitive mechanisms that govern selective access to WM and could ultimately be used to present relevant information when the brain is most susceptible to incorporate this into WM. The project will be carried out at the Oxford Centre for Human Brain Activity, together with leading scientist in the electrophysiological study of WM (Anna Christina Nobre and Mark Stokes) and the analysis of MEG data (Mark Woolrich). This will allow me to not only perform the proposed research to the highest standard, but also to further develop several key skills (broaden my conceptual horizon, acquire novel analysis techniques, establish long-term collaborations, translate research, etc.) that will further my independence as a researcher and place me in the ideal position to start my own research group within few years after the fellowship.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194970;654477;GETUI;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Gestures in Tangible User Interfaces;1/11/2015;31/10/2017;;"GETUI investigates through user studies the use of gestures in interaction with Tangible User Interfaces (TUIs) in the context of technology-based assessment (TBA) of collaborative and complex problem solving skills. Collaborative problem solving is defined as the capacity to recognise the perspective of other people in a group, participate, contribute knowledge, recognise the need for contributions and build knowledge and understanding as member on a collaborative setting (Ras et al. 2013). Most of the research in TBA of collaborative problem solving skills dealt with the improvement of assessment of traditional skills. However, the focus should be on the so-called 21st Century skills: CPS, creativity, critical thinking, learning to learn, decision-making. Ras et al. (2013) state that for many challenges in TBA, ICT are the solution to assess 21st Century skills, but also the problem, as scientific knowledge about how assessment models need to be adapted as well as practical knowledge about how to create more authentic problem situations with future assessment tools are lacking. Until now there is no TUI that has been systematically used and evaluated in the context of TBA. Moreover, in TBA, gestures on TUIs have not been yet explored. Thus not only is the research of TUI as an assessment construct a new research field, but also the dimension of gestures makes GETUI an innovative and timely project. This interdisciplenary research will not only fill the gap of scientific knowledge, but will also have an impact at a European level creating new instruments for assessing 21st Century skills based on capturing behavioural indices of human-computer and human-human interactions in collaborative TBA situations.


Ras E, Maquil V, Foulonneau M, Latour T (2013) Empirical studies on a Tangible user interface for technology-based assessment: Insights and emerging challenges. Pedagogy and Technology: Harmony and Tensions International Journal of e-Assessment, 3(1).";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY;LU;;; 195153;655677;GutILC3;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cell-cell interactions critical to ILC3 function in the human gut;1/04/2015;31/03/2017;;"Inflammatory bowel disease (IBD), conferring a dramatically increased risk for development of colorectal cancer (CRC), results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. However, the exact etiology of IBD is unknown. Building up on high impact papers from the host group reporting on the recently discovered innate lymphoid cells (ILCs) as key players in mucosal inflammation, I now aim to unravel the role for ILCs in IBD and CRC. Interestingly, while the IL-22 producing ILC3 seem to be crucial in maintaining intestinal homeostasis, the IL-17 and IFN-gamma-producing ILCs can cause inflammation in a mouse model of colitis and are present in human IBD. Furthermore, ILCs were recently described to be involved in modulating immune responses, by interacting with CD4\ T cells and mononuclear phagocytes in the mouse intestine.
I aim to identify critical pathways in the crosstalk of ILC3 with other immune cells in the human intestine. The ultimate purpose is to assess how these interactions affect immune homeostasis and disease progression in IBD and CRC. We will pinpoint crucial interaction molecules and cellular processes that can be used for monitoring current therapies as well as finding new therapy targets for IBD and CRC.
This truly translational proposal utilizes, in an optimal manner, unique state-of-the-art techniques and patient materials to provide novel insights into the etiology of IBD and CRC. The excellent track record of the hosting group, the highly suitable infrastructure provided by the host institution and my own extensive research experience ensures a high degree of feasibility. Furthermore, this project provides excellent training opportunities, skill advancement possibilities and career prospects for me and its results are expected to have a direct impact on the European society.";173857,2;173857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;KAROLINSKA INSTITUTET;SE;;; 194779;652373;SIADE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Spatial Decision Support System for Transportation Planning;1/10/2014;31/03/2015;;SIADE is a GIS-based decision support system for public transportation planning. It facilitates the process to improve efficiency in public transportation, with an special emphasis in social and economical parameters. Implementing a strategy to manage urban transportation involves several mathematical models allowing transportation network analysis and estimating their impact in both the environment and the users, while defining automatic procedures to compare different scenarios.;71429;50000;H2020-SMEINST-1-2014;SME-1;TERRAIN TECHNOLOGIES SL;ES;;; 194785;652490;FLOTA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Floating Offshore Photovoltaic systems;1/11/2014;30/04/2015;;"The innovation project consists in a system of floating photovoltaic panels for the decentralized generation and stocking of energy at off shore fish farms (and more generally sea activities with necessity of electricity). The project FLOTA (Floating Offshore Photovoltaic systems) addresses the industrial problem of the autonomous supply of sustainable and green energy for the quickly increasing industrial branch of fish farms.
Goals of this feasibility study is to finalize the business plan for the development of a new company of a spin-off fully dedicated to sea advanced systems, the finalization of specific design activities on the system and the creation of a small scale demonstrator that will be the key element of the dissemination for this system.";71429;50000;H2020-SMEINST-1-2014;SME-1;active innovation management;FR;;; 194825;652978;LIAGAN;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Literature against anti-Semitism (1940-1944). French and Soviet emigr writers in France against the persecution of the Jews;1/06/2015;31/05/2017;;"The research project Literature against anti-Semitisme (1940-1944). French and Soviet emigr writers in France against the persecution of the Jews aims at investigating the views which writers had of the persecution of the Jews in Occupied France. More exactly, it aims at approaching the texts of the writers who reacted to the injustices suffered by the Jews who became exiles and were hunted down as Others, before being simply eliminated. In this context, we intend to study various works of fiction (stories, novels, poetry) in which the question of the persecution of the Jews is at stake. The project is defined by two axes: (1) the French writers who raised their voices against the persecutions of which the Jews were victims in France, (2) migr writers from Central and Oriental Europe (Russian, Russian-language, Georgian) who lived in France during the Occupation and who also stood up against these injustices.
Two circumstances which are specific to France have to be taken in account. Firstly, the persecution of the Jews in France implemented by the Vichy government during the Occupation needs to be understood in the context of a national/local anti-Semitic policy the roots of which are to be found in the pre-war society. Secondly, the public role of the writers was more important compared to other countries. If many of them had raised their voices against the events unfolding in Europe, this voice is acquiring a decisive importance in the shaping of public opinion. In approaching the problem of resistance in France to the Nazi occupiers, it would be necessary to consider the flows of immigration affecting the country in the twenties and thirties, when a large number of intellectuals and writers arrived from Central and Eastern Europe and took part in French cultural and public life, among other things by sharing its opposition to the rise of Nazism in Europe.";185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE DE PARIS-SORBONNE (PARIS IV);FR;;; 194987;654723;Solarfuels;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Engineering Silicon Carbide Nanowires for Solar Fuels Production;28/08/2015;27/08/2017;;By 2020, the European Union aims to reduce greenhouse gas emissions by 20-30% and increase renewable energy share to 20%. This scenario has imposed urgent needs to develop fossil fuel alternatives like solar fuels. In order to produce solar fuels, the coupled reduction of CO2 and H2O is one of the most promising processes. However, the generation of efficient, stable and low-cost material for CO2/H2O reduction remains a big challenge. Silicon carbide nanowires (SiC NW) exhibit the unique properties of large surface-to-volume ratio, tuneable transport properties and quantum size effects, which is very promising for the reduction of CO2/H2O to produce solar fuels. To date, the studies on SiC NW for CO2/H2O reduction are limited due to the lack of (1) large-scale production techniques, (2) in situ characterization of the growth mode, and (3) there are no economical devices available for the evaluation of SiC NW. This project, SOLARFUELS, proposes the engineering of SiC NW for solar fuels production through the development of a carbon nanotube template method for large-scale synthesis of SiC NW combing with in situ characterization of SiC NW during growth and post-mortem. Design of an economically viable device is envisaged to exploit the in house generated SiC NWs. By introducing novel multiple sample holders for atmospheric gaseous reaction, the designed device can enable efficient catalyst/reactant contact along the vertically orientation of SiC NW and reduce the cost for the device by at least a half.The SOLARFUELS is built across research areas of materials science, chemistry, chemical and device engineering. It perfectly integrates the Experienced Researcher (ER)s skills in solar energy application/device development and the Supervisors expertise in nanomaterials synthesis/characterization. It will play an important role in advancing ER's career for a permanent position and in addition it will contribute to new approaches to further host's solar fuel research.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194889;653667;REAPPAST;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;High-Resolution Approach in Middle and Upper Palaeolithic sites for reconstructing Social dynamic and Technical behaviours;16/07/2015;15/07/2017;;"REAPPAST will investigate site formation processes from a new perspective casting light on socio-technical organisation and the relations between group size and complex skills, which are the focus of current scientific debate on Middle and Upper Palaeolithic, addressing two questions: 1) How did the socio-economic organisation reflect itself in the spatial and temporal organisation of technical activities in Palaeolithic residential camps? 2) Which was the group size in single occupation areas, and with which palaeodemographic implications?
Specifically multidisciplinary analysis of lithic assemblages from two sites in N-E Spain will be used to investigate occupation areas in a Neanderthal and a Sapiens community, and to test hypotheses on number of co-residents on the basis of spatio-temporal relation between functional areas and number of single productive events carried out within these areas. REAPPAST will exploit the remarkable expertise of IPHES, which is a world-leading group in high-resolution approach. Methods will include RMU analysis, refits, experimental archaeology, spatial and computational modeling, the combination of which constitutes an innovative strategy. Two secondments will allow me to reach the highest competencies in experimentation (Universit de Bordeaux) and in point pattern analysis (University College of London).
REAPPAST will 1) improve my formation with diversified and new training skills to reach a mature scientific position and open new perspectives of career; 2) extend the international network and visibility of both me and the host institutions through international and inter-sectoral mobility and peer-reviewed publications; 3) bring important benefits to the European research, deepening our knowledge on hunter-gatherer socio-economic strategies in the Late Pleistocene; 4) bring social impact promoting the relevance of research in Prehistory in local schools, in public events and in European museums.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;FUNDACIO PRIVADA INSTITUT CATALA DE PALEOECOLOGIA HUMANA I EVOLUCIO SOCIAL;ES;;; 194876;653605;XERIC;SIGNED;H2020-EU.3.4.;GV-2-2014;H2020;Innovative Climate-Control System to Extend Range of Electric Vehicles and Improve Comfort;1/06/2015;31/05/2018;;"The limited capacity of electric batteries combined with the substantial amount of energy needed to run auxiliary equipment dramatically affects range capability of electric vehicles (EVs). For instance, the climate control system in summer conditions can absorbs up to 40-60% of the available energy.
The aim of the project is to develop an energy friendly climate control system capable to reduce of at least 50% the energy used for passenger comfort all over the year (i.e., heating, cooling and dehumidifying).
Actually, in summer conditions air is dehumidified and cooled by best available technologies that use climate control systems based on a Vapor Compression Cycle (VCC), which cools air below its dew point. Alternatively, desiccants are used as an energy efficient way to dehumidify air without cooling it below its dew point, which allows to control temperature and humidity independently.
In our project we plan to exploit technologically the desiccants properties by using aqueous solutions of desiccants (e.g., LiCl, CaCl2) housed in a membrane contactor. Our idea is to develop a hybrid system in which air can be dehumidified without the need to be cooled below its dew-point. This will be done by combining a liquid desiccant cycle (which deals with the latent load) with a traditional vapour compression cycle (which faces the sensible load). In fact, in such a system the VCC would operate at higher refrigerant evaporation temperature and at lower condensation temperature.
The core of the system is an innovative highly compact and energy efficient three-fluids-combined-membrane-contactor that simultaneously works with air, desiccant solution, and refrigerant.
Specifically, the climate control system will be capable to
- reduce more than 50% the energy used for passenger comfort,
- have a lifetime longer than 10 years,
- easy industrialization and customization for EVs currently on the market,
- cost from 1,200 to 3,000 Euro.

Project Coordinator: GVS SPA, IT";4621280;4621279,75;H2020-GV-2014;RIA;GVS S.P.A.;IT;"FRIGOMAR SRL;European Membrane House;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;UNIVERSITAET DUISBURG-ESSEN;TECNOLOGIE INNOVATIVE PER IL CONTROLLO AMBIENTALE E LO SVILUPPO SOSTENIBILE SCRL;ASOCIACION DE LA INDUSTRIA NAVARRA;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.";"IT;BE;DE;ES"; 194879;653631;FOX;SIGNED;H2020-EU.3.4.;MG-8.1b-2014;H2020;Forever Open infrastructure across (X) all transport modes;1/05/2015;31/10/2017;;"An efficient and high-quality transport infrastructure is a fundamental requirement for the connectivity of people and goods in Europe and basis for economic growth, competitiveness and territorial cohesion. In general, the transport network in Europe is of a high standard but is still fragmented regarding the geographical distribution and the transport modes.
In recent years, first networking activities and exchange of strategic programmes among the stakeholders of the four transport modes road, rail, water and air can be noticed but still a mono-modal, mono-disciplinary culture exists. In the light of the future challenges, e.g. increasing transport demand, ageing infrastructure, scarcity of natural resources, changing climatic conditions, it is inevitable to strengthen the collaboration of the single transport modes in order to create an improved future integrated and functioning transport system for Europe, despite of limited financial resources of the owners of the transport network.
The FOX project aims to develop a highly efficient and effective cross-modal R&D environment and culture which meets the demanding requirements of the transport and connectivity. Based on already existing programmes and agendas related to the aspects of co-modal transport research, the FOX project will identify common needs and innovative techniques in the areas of construction, maintenance, inspection, and recycling & reuse of transport infrastructure. This will be reached by the involvement of all stakeholders (owners, researchers, and industry) of the four transport modes in a phased approach: Starting with the determination of the state-of-the-art in research and practice, in the next step the most promising practices and ideas will be identified. By mapping the common needs, the final aim is to establish a cross-modal Working Group to develop a roadmap for the whole transport sector and set the agenda for further improvement of cross-modal research development innovation.";929753,53;929753,53;H2020-MG-2014_SingleStage_B;CSA;FORUM DES LABORATOIRES NATIONAUX EUROPEENS DE RECHERCHE ROUTIERE;BE;"EURNEX e. V.;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;BUNDESANSTALT FUER STRASSENWESEN;INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS, DE L'AMENAGEMENT ET DES RESEAUX;SERVICE TECHNIQUE DE L'AVIATION CIVILE;ZAVOD ZA GRADBENISTVO SLOVENIJE";"DE;NL;FR;SI"; 194851;653339;CODECS;SIGNED;H2020-EU.3.4.;MG-7.2b-2014;H2020;COoperative ITS DEployment Coordination Support;1/05/2015;30/04/2018;;Multifaceted research initiatives and field operational tests have proven the potential of Cooperative Intelligent Transport Systems and Services (C-ITS) to contribute to a safer, more flexible, mobile, sustainable and comfortable future society. In first deployment activities like the Cooperative ITS Corridor, SCOOP@F and COMPASS4D pilot projects,users will precociously experience the benefits of cooperative traffic safety and efficiency services, enabled by the integration of new technology (e.g. ETSI ITS G5) into vehicles and infrastructure. As a considerable stakeholder organisation, the Amsterdam Group pursues a harmonised C-ITS system realisation providing benefits to all users. It facilitates joint work for a growing variety of stakeholders such as road operators, automotive industry, cities and regions. The Coordination and Support Action COoperative ITS DEployment Coordination Support (CODECS) supports the European Commission and the manifold stakeholders involved in C-ITS deployment in finding strategic and technical policy solutions and processes for a consolidated C-ITS roll-out. CODECS serves as hub for transparent information and knowledge transfer on function approaches, experiences and lessons-learned by stakeholders active in the initial deployment. To ensure European-wide seamless (cross-border) interoperability and end-user experiences, CODECS develops a harmonised standards profile supporting a growing amount of C-ITS services. To address key organisational and technology related issues, CODECS will derive a strategic common road map from preferences of the involved stakeholders, giving direction for innovation, testing, standardisation and deployment beyond Day One. CODECS also supports future C-ITS common deployment by achieving a clear understanding on policies, roles and responsibilities. CODECS does convey these insights to the C-ITS deployment platform initiated by the European Commission and also to the Amsterdam Group.;1584967,38;1584967,38;H2020-MG-2014_SingleStage_B;CSA;ITS NIEDERSACHSEN GMBH;DE;"VOLKSWAGEN AG;BUNDESANSTALT FUER STRASSENWESEN;POLIS - PROMOTION OF OPERATIONAL LINKS WITH INTEGRATED SERVICES, ASSOCIATION INTERNATIONALE;MINISTERIE VAN INFRASTRUCTUUR EN MILIEU;PAULSCONSULTANCY BV;ANDERSEN NIELS PETER SKOV;BAYERISCHE MOTOREN WERKE AKTIENGESELLSCHAFT;BMW FORSCHUNG UND TECHNIK GMBH;AUTOMOBIL CLUB ASSISTENCIA SA;INTENS CORPORATION SRO";"DE;BE;NL;DK;ES;CZ"; 194955;654318;FLOWLASER;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Manipulation of Flow Characteristics Using Laser Energy Deposition;1/08/2015;31/07/2017;;"Travelling at high speeds entails overcoming adverse effects, such as regions of high heat transfer and surface pressures, unsteady shock waves, fluid-structure interactions, together with the requirement of drag reduction. One method of flow and flight control is energy addition. It is the objective of the proposed study to utilise this technique for the development of:
1) mitigation schemes for the avoidance or modification of localised regions of high heat transfer and surface pressure of high-speed vehicles.
2) methods for controlling local flowfield characteristics and the location of shocks e.g., in engine inlets, and wing-fuselage junctions.
The research program combines both branches of research, namely, experimental and numerical. It aims to advance the frontiers of supersonic and hypersonic aerothermodynamics and propulsion and it will firmly establish a UK/European lead in research on laser energy systems for flight and flow control of high-speed vehicles. This programme will be supported by the excellent research environment provided by the host, Prof Kontis, University of Glasgow UK, with state-of-the-art facilities for research development, testing and training. This programme also will benefit from the strong links between the host group and leading UK and international research groups.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF GLASGOW;UK;;; 194773;652292;RepHorm;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;A device that will dramatically improve the protection of babies during birth. It will monitor the child continuously with better acuity, resulting in better clinical outcomes at a lower cost.;1/10/2014;28/02/2015;;"The objective of this Phase 1 application is a feasibility study to assess the commercial viability of RepHorM, and quantify the business opportunity.
This project is to develop a real-time in vivo infant monitor that safe guards the baby during birth. This achieved with a fiber optic based biomarker sensor. This device will for the first time provide doctors with a real-time, continuous and objective measure of a babys health during labour by incorporating this technology into an existing medical device. The learning curve will be small in taking up the new device and the specific biomarker, is very familiar to obstetricians as well as other clinicians, and the threshold levels for intervention are already established.
This Innovative solution uses latest technology deployed to an old, long standing problem. The research into the sensor chemistry has been now completed and this activity has moved the technology form TRL 3 to the current TRL 6. The worldwide market for monitoring was 6.2 Billion in 2010 and is predicted to increase by 4.4% compound annual growth rate (CAGR) to reach 8 Billion in 2016. None of the current methods offer clear advantages over one another. The general trend in medicine is towards individual bedside or in-patient testing of key biomarkers, in particular, there is a trend towards continuous bio-diagnostics.
BlueBridge Technologies hope to use Phase 1 to identify obstacles to successful product development and launch, and develop solutions to manage them. The work will then serve to better understand and describe exactly what type of product(s) the market requires and subsequently estimate the development costs, time to Market and provide the inputs needed for a Phase 2 application.

Babies and the market need this product as they are currently under served by the current offerings and we passionately want to lead the response to this noble call.";71429;50000;H2020-SMEINST-1-2014;SME-1;BLUEBRIDGE TECHNOLOGIES LTD;IE;;; 195138;655601;Baltic Mikrorayon;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Past, Present, and Future Lives of Soviet Housing Estates in the Baltic States;1/01/2016;31/12/2017;;"In Central and Eastern Europe (CEE), modernist housing estates, built between the 1950s and 1990s to meet housing demand and rebuild cities after World War II, introduced revolutionary changes in urbanization. Today, overcoming the challenges posed by vast housing estates presents one of the greatest challenges faced in post-Socialist cities. To address a gap in knowledge about socialist urban planning implementation (especially the construction of mikrorayon) in the Baltic States, I propose to interview planners and architects who were active practitioners during the Soviet era (as well as those practicing more recently) to analyse past, present, and future lives of housing estates in Estonia, Latvia and Lithuania. The project proposed for this IF is not only a natural progression of my research trajectory, it is also transformative because it applies my expertise to multi-disciplinary research that covers a range of research questions and avenues of inquiry. The project will produce broad impacts on research methods (interviews of original actors in residential settlements), new knowledge on the history of urbanization, and recommendations for present-day urban planning in cities in CEE.
This Individual Fellowship requires a 24-month academic stay at the University of Tartu (UT), Estonia where I will engage in training-through-research supervised by Prof. Tiit Tammaru, Professor and Senior Research Fellow in the Institute of Human Geography at UT. The project will give me new hands-on experience in interviewing and archival research and I will produce important publications that will (1) help me establish myself as the pre-eminent North American scholar on architecture, town planning, and urban geography in the Baltic States, and (2) assist my career advancement (from Associate Professor to Professor) at my home institution, the University at Buffalo.";148582,8;148582,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;TARTU ULIKOOL;EE;;; 194907;653884;SafeCloud;SIGNED;H2020-EU.3.7.;DS-01-2014;H2020;Secure and Resilient Cloud Architecture;1/09/2015;31/08/2018;;"Cloud infrastructures, despite all their advantages and importance to the competitiveness of modern economies, raise fundamental questions related to the privacy, integrity, and security of offsite data storage and processing tasks. These questions are currently not answered satisfactorily by existing technologies. Furthermore, recent developments in the wake of the expansive and sometimes unauthorized government access to private and sensitive data raise major privacy and security concerns about data located in the cloud, especially when data is physically located, processed, or must transit outside the legal jurisdiction of its rightful owner. This is exacerbated by providers of cloud services that frequently move and process data without notice in ways that are detrimental to the users and their privacy.

SafeCloud will re-architect cloud infrastructures to ensure that data transmission, storage, and processing can be (1) partitioned in multiple administrative domains that are unlikely to collude, so that sensitive data can be protected by design; (2) entangled with inter-dependencies that make it impossible for any of the domains to tamper with its integrity. These two principles (partitioning and entanglement) are thus applied holistically across the entire data management stack, from communication to storage and processing.

Users will control the choice of non-colluding domains for partitioning and the tradeoffs between entanglement and performance, and thus will have full control over what happens to their data. This will make users less reluctant to manage their personal data online due to privacy concerns and will generate positive business cases for privacy-sensitive online applications such as the distributed cloud infrastructure and medical record storage platform that we address.";3298987,5;2150810;H2020-DS-2014-1;IA;INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;PT;"CYBERNETICA AS;TECHNISCHE UNIVERSITAET MUENCHEN;CLOUD&HEAT TECHNOLOGIES GMBH;UNIVERSITE DE NEUCHATEL;MAXDATA SOFTWARE SA;INESC ID - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA";"EE;DE;CH;PT"; 195083;655274;PEDIGREE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Pluralistic Economics for Development in Green Economic Enhancement;1/01/2016;31/12/2017;;"The question of which economic framework (or sets of frameworks) is (are) appropriate for providing policy prescriptions conducive to ecological sustainable has gained renewed interest within the community of ecological economists and political economists. To help answer this question I propose to investigate the suitability of four economic frameworks neoclassical environmental economics, non-Walrasian neoclassical environmental economics, institutional ecological economics, and ecological Marxian political economy, for providing effective and coherent policy prescriptions for renewable and sustainable energy resources, specifically for electricity generation.
The inquiry will be both philosophical/methodological and empirical. The four frameworks will be interrogated against case studies of the UK, Germany, Norway, France, Canada, and the US. The case studies will be comprised of analyses of the socio-economic, historical, political, and cultural backdrop of energy resources in each country. The results of this interrogation will then be used to assess the suitability of the four frameworks for providing policy prescriptions conducive to ecological sustainability with regards to their respective methodologies including ontology, epistemology, methodology (to include methods as well), and ideology. The case for methodological pluralism will be assessed and a notion of pluralism developed for economic frameworks concerned with ecological sustainability.
The benefits that will be gained from undertaking this research program at the ERA level will accrue to economists and social scientists first by giving them better analytical and conceptual tools, and all those, including policy makers, politicians, and business leaders who depend on those tools afterwards through better results.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ANGLIA RUSKIN UNIVERSITY HIGHER EDUCATION CORPORATION;UK;;; 194972;654424;SustBracedMHaz;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sustainable steel braced frame for multi-hazard mitigation;31/08/2015;30/08/2017;;"Modern societies need building infrastructure that is designed and maintained according to high sustainability and resilience standards. Sustainability in construction can be realized with demountable (easy to deconstruct) structures that enable change of the building geometry (adaptability) and reuse of materials and structural members at the end of the building life. Resilience can be realized with structures that can be easily repaired, if damaged, so that building service can be restored within an acceptable short, if not immediate, time after extreme loading conditions. Moreover, the need to design structures against multiple natural (e.g. earthquakes) and man-made (e.g. bomb blast) hazards has been recognized. The goal of the project is to address the aforementioned urgent societal needs by developing a novel steel concentric braced frame (CBF) that can, for the first time, simultaneously achieve the following overall objectives: (a) Sustainability in construction, (b) Enhanced progressive collapse resistance and reparability against a sudden loss of column due to bomb blast; and (c) Easy inspection and repair of damage to allow rapid return to building use and occupation after strong earthquakes.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF WARWICK;UK;;; 194836;653216;MICEXPRESS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding how selection for body weight in mouse operates at the RNA level;1/09/2015;31/08/2017;;The aim of this project is to enhance our understanding of how genetic selection for body weight in mouse drives changes at the RNA level. This is a key point for quantitative genetics because a better knowledge of the genetic control of gene expression would imply a better prediction of changes in the regulatory networks and subsequently in the phenotype. Moreover, the biological insight gained by this understanding could, in turn, be used by the animal breeding industry to design more efficient breeding strategies. However, generally, genetic studies focus on understanding mean phenotypic differences among genotypes, although genes can also lead differences in the phenotypic variance between genotypes. Thus, this research will use a systems approach to model the genetic control of both, the mean and the variance of gene expression, and to identify regulatory networks than can be modified by selection. In addition, important environmental effects, such as maternal effects (e.g. uterine capacity), play an important role on the response to selection for growth in mammals. The second project aim is to elucidate how maternal effects shape the expression of genes and gain insight into the mechanisms underpinning gene by environment interactions. The recent emergence of high throughput technologies such as mRNA sequencing allows the study of the genetic and environmental makeup of cellular phenotypes. Furthermore, answering these questions require experimental designs and biological resources that are not usually available. The Roslin Institute has an extraordinary resource to carry out this research. After many generations of divergent selection for body weight multiple mouse lines were inbred, and kept inbred through brother-sister mating for over fifty generations. Four of these lines will be used in the current project. Hence, this project will capitalize on this extraordinary resource jointly with the emerging genomic tools for addressing these important questions.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF EDINBURGH;UK;;; 194861;653412;Flex-ON;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Flexible Optical Networks Time Domain Hybrid QAM: DSP and Physical Layer Modelling;16/10/2015;15/10/2017;;"The delivery of fast Internet connections all over Europe is a primary goal of Horizon 2020. In order to avoid the upcoming capacity crunch on transport optical networks, there is an urgent need for a strong investment in the research and development of future-proof optical broadband infrastructures. The Flex-ON project will investigate new technological paradigms in terms of signal generation, digital processing and control-plane management for novel flexible and high-capacity transport optical networks. The primary technical objective of the project is to develop and implement a flexible transceiver prototype with intelligent reconfigurability and arbitrarily low bit-rate granularity. The development of this technology will enable to increase the network capacity and the spectral/energy efficiency, while providing a future-proof flexible solution for an increasingly heterogeneous global network.

The main scientific/industrial contributions of the project include:
- the optimization of signal modulation to improve spectral efficiency and bit-rate granularity;
- the development of novel DSP strategies and algorithms to enable flexible networking;
- the development of novel numerical tools for physical layer modelling under the nonlinear (NL) propagation regime;
- the optimization of NL compensation methods to improve the trade-off between spectral efficiency and signal reach.

In order to guarantee a sustainable and smooth upgrade of currently installed optical transmission systems, Flex-ON encompasses a dual-generation approach:
- 1st generation: fixed frequency grid (ITU-T: 50 GHz) and fixed symbol-rate transceivers with variable bit-rate enabled by time domain hybrid QAM techniques;
- 2nd generation: flexible frequency grid (ITU-T G.694.1: 12.5 GHz) and variable symbol-rate transceivers.

The tight collaboration with industry players ensures that the newly proposed concepts, software and prototypes will enhance the European competitiveness in the telecom sector.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;POLITECNICO DI TORINO;IT;;; 194770;652164;FIND;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Feasibility Assessment of a Foot INflammation Detection Device;1/11/2014;30/04/2015;;"Hemics is a medical device company focusing on monitoring solutions for inflammatory joint diseases. This proposal describes how Hemics (SME) will deliver a feasibility study on the development, validation and commercialization of an imaging device (FootScan) to monitor joint inflammation in the feet of patients with Rheumatoid Arthritis (RA).

Current treatment of RA focuses on the reduction of disease activity to remission by use of drug therapy. Treatment of RA is guided by monitoring the disease activity. The latest scientific evidence shows that tight control strategies are recommended in the early stages of RA as the best way of preventing escalation of the disease.
The DAS28 score is the most used monitoring method, although it is too subjective, time consuming and painful for the patient. Given the time constraints tight control is hardly possible through the DAS28 method. Other, more objective and sensitive, methods (eg. X-Ray, MRI) are time-consuming and too costly to use as a regular basis for monitoring.

This proves the clinical need for an objective, sensitive and time saving method to monitor RA, enabling tight control and treatment of, now often undiagnosed, subclinical inflammation.

The niche market of rheumatology consists of 16.000 rheumatologists worldwide. If every three rheumatologists would use a FootScan, the potential market would consist of approximately 5300 units. With a life expectancy of eight years and a pricing range between 60.000 and 80.000 this market represents a value of 46.690.000 per annum.

In 2015 Hemics plans to start the product engineering phase. To reach that milestone, Phase 1 feasibility assessment will cover a technical feasibility study as well as a business feasibility study. The objective of the feasibility assessment is to optimize the optical technology for the FootScan and to develop a business and implementation plan for successful commercialization.";71429;50000;H2020-SMEINST-1-2014;SME-1;Hemics B.V.;NL;;; 194821;652890;EMTECS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Electrophile-Mediated Three-Component Enantiospecific Cross-Couplings;1/03/2015;28/02/2017;;One of the most challenging aspects of Suzuki-Miyaura reactions is the stereospecific cross-coupling of sp3 substituted boronic esters with aryl halides. Recently, the host group developed a metal-free, stereospecific cross-coupling reaction of chiral alkyl boronates with electron-rich aromatics, promoted by the use of electrophilic oxidants. This proposal seeks to substantially extend this cross-coupling chemistry through the application of a range of different electrophiles that will not only mediate the cross-coupling process, but also remain in the final product, creating multiple carboncarbon bonds stereospecifically. In particular, the application of electrophilic organometallic species will be investigated so as to take advantage of the power of metal catalysts in the formation of carboncarbon bonds. Through the use of this strategy, doubly functionalised enantiopure aromatic compounds may be formed in a very efficient three-component coupling process that utilises readily accessible enantiopure alkyl boronic esters, electron-rich aromatics and catalytically generated organometallic electrophiles.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY OF BRISTOL;UK;;; 194841;653256;TRILLION;SIGNED;H2020-EU.3.7.;FCT-14-2014;H2020;TRusted, CItizen - LEA coILaboratIon over sOcial Networks;1/09/2015;31/08/2018;;"Community policing promotes the implementation of bi-directional collaboration channels between citizens and Law Enforcement Agencies (LEAs). By enhancing the discovery of relevant and up to date information, it speeds up the detection of risks, eases their prevention and builds a continuum of collaboration which motivates citizens and LEAs to work together.
Over 36 months, TRILLION - TRusted, CItizen - LEA coILaboratIon over sOcial Networks - delivers a fully-fledged platform to support the extensive collaboration between citizens and LEAs. The operational environment of the platform is not limited to an on-going crisis, but also extends to the period before it through early identification and prevention of emerging risks. Major challenges addressed by TRILLION include creating the necessary trust to entice provision of information, ensuring that the information leads to realistic and credible knowledge and using this knowledge through secure bi-directional communications to guide actions of individuals closest to an identified risky situation. TRILLION delivers a comprehensive service based platform and mobile applications that support the knowledge-based, real-time collaboration among law enforcement agents, first responders and citizens whilst ensuring that privacy and data protection are taken into account.

The TRILLION consortium and supporting organisations include 6 citizen communities, 6 law enforcement stakeholders, 3 industrial players and 5 universities and research centres. Extensive trials take place through pilots, early validations and serious game based training across Italy, Portugal, Sweden, the Netherlands and the United Kingdom, involving close to 2.000 citizens and law enforcement agencies representatives.";4263407,5;4263407,5;H2020-FCT-2014;RIA;ENGINEERING - INGEGNERIA INFORMATICA SPA;IT;"ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;STICHTING DUTCH INSTITUTE FOR TECHNOLOGY, SAFETY & SECURITY;UNIVERSITY OF GREENWICH;XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO;COMUNE DI ANCONA;Technological Educational Institute of Piraeus;CITTA DI LECCE*COMUNE DI LECCE;ATOS SPAIN SA;Ministrio da Justia;MITTUNIVERSITETET;ROYAL UNITED SERVICES INSTITUTE FOR DEFENCE AND SECURITY STUDIES;INOV INESC INOVACAO - INSTITUTO DE NOVAS TECNOLOGIAS";"EL;NL;UK;SI;IT;ES;PT;SE"; 194764;652101;Aeropaft;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Delay of flow separation and stall on Aerofoils using a Passive Flow control Technology which will improve aerodynamic performance and stability of wind turbines increasing their range of operation;1/11/2014;30/04/2015;;"Flow separation and dynamic stalling in aerofoils result in increased drag, reduced lift and increased dynamic loads on aerodynamic devices/vehicles. This culminates in reduced aerodynamic efficiency and increased structural vibrations, which are noisy and reduce the operating life of aerodynamic devices. To delay flow separations and dynamic stalling, flow control is engaged either actively (artificial means) or passively (natural means). This project describes a novel passive flow control method (Aeropaft) to be applied primarily in the wind turbine (WT) industry, then to aircraft and ground and marine vehicles.
Wind energy is the fastest growing Renewable Energy source (RES) at 24.4% per year. To keep pace with growing demand, there is need for advanced technologies to increase the aerodynamic efficiency. Aeropaft is a simple technology exploiting high velocity currents from near the leading edge (via internal ducts) to re-energise the free-stream flow at the top of an aerofoil. This results in a 5% increase in electrical power yield for a 1MW WT, increase in lift (~16%), reduction of profile drag force (~7%) at higher aerofoil angles of incidences (>12o), and the reduction of wear caused by vibrations. We will penetrate 1% of the global WT market and 10% of the European market. Licensed Manufacturers stand to gain a 0.33% increase in market value and revenue of 1.72bn, while utility companies gain 101,013 per annum through savings and increased energy output per WT. Our revenue will come through licensing at 0.2% of the whole turbine cost translating to revenue of 10.3m and profits of 7.72m, five years post commercialization.
Phase 1 will entail a market study, partner search, assessing structural integrity issues and developing an IP and commercialisation strategy.
Phase 2 will be to modify blades of existing WTs with our technology and test demonstrate in the operational environment.";71429;50000;H2020-SMEINST-1-2014;SME-1;JARILO LIMITED;UK;;; 194864;653426;PRIVACY FLAG;SIGNED;H2020-EU.3.7.;DS-01-2014;H2020;Enabling Crowd-sourcing based privacy protection for smartphone applications, websites and Internet of Things deployments;1/05/2015;30/04/2018;;"Privacy Flag combines crowd sourcing, ICT technology and legal expertise to protect citizen privacy when visiting websites, using smart-phone applications, or living in a smart city. It will enable citizens to monitor and control their privacy with a user friendly solution provided as a smart phone application, a web browser add-on and a public website. It will:

1.Develop a highly scalable privacy monitoring and protection solution with:
- Crowd sourcing mechanisms to identify, monitor and assess privacy-related risks;
- Privacy monitoring agents to identify suspicious activities and applications;
- Universal Privacy Risk Area Assessment Tool and methodology tailored on European norms on personal data protection;
- Personal Data Valuation mechanism;
- Privacy enablers against traffic monitoring and finger printing;
- User friendly interface informing on the privacy risks when using an application or website.

2.Develop a global knowledge database of identified privacy risks, together with online services to support companies and other stakeholders in becoming privacy-friendly, including:
- In-depth privacy risk analytical tool and services;
- Voluntary legally binding mechanism for companies located outside Europe to align with and abide to European standards in terms of personal data protection;
- Services for companies interested in being privacy friendly;
- Labelling and certification process.

3.Collaborate with standardization bodies and actively disseminate towards the public and specialized communities, such as ICT lawyers, policy makers and academics.

11 European partners, including SMEs and a large telco operator, bring their complementary technical, legal, societal and business expertise; strong links with standardization bodies and international fora; and outcomes from over 20 related research projects. It will build a privacy defenders community and will establish a legal entity with a sound business plan to ensure longterm sustainability and growth.";4538437,5;3142999,75;H2020-DS-2014-1;IA;HELLENIC TELECOMMUNICATIONS ORGANIZATION S.A. - OTE AE (ORGANISMOS TILEPIKOINONION TIS ELLADOS OTE AE);EL;"VELTI ANONYMI ETAIREIA PROIONTON LOGISMIKOU & SYNAFON PRIONTON & PIRESION;UNIVERSITE DU LUXEMBOURG;DRUSTVO ZA KONSALTING, RAZVOJ I IMPLEMENTACIJU INFORMACIONIH I KOMUNIKACIONIH TEHNOLOGIJA DUNAVNET DOO;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;H W COMMUNICATIONS LIMITED;ISTITUTO ITALIANO PER LA PRIVACY;LULEA TEKNISKA UNIVERSITET;ARCHIMEDE SOLUTIONS SARL;INSTITOUTO TECHNOLOGIAS YPOLOGISTONKAI EKDOSEON DIOFANTOS;UNIVERSITY OF BRISTOL;INTERNATIONAL ASSOCIATION OF IT LAWYERS (IAITL) FORENING;MANDAT INTERNATIONAL ALIAS FONDATION POUR LA COOPERATION INTERNATIONALE";"EL;LU;RS;UK;IT;SE;CH;DK"; 194947;654182;ENVRI PLUS;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-4-2014-2015;H2020;Environmental Research Infrastructures Providing Shared Solutions for Science and Society;1/05/2015;30/04/2019;;ENVRIPLUS is a cluster of research infrastructures (RIs) for Environmental and Earth System sciences, built around ESFRI roadmap and associating leading e-infrastructures and Integrating Activities together with technical specialist partners. ENVRIPLUS is driven by 3 overarching goals: 1) favoring cross-fertilization between infrastructures, 2) implementing innovative concepts and devices across RIs, and 3) facilitating research and innovation in the field of environment to an increasing number of users outside the RIs. ENVRIPLUS organizes its activities along a main strategic plan where sharing multi-disciplinary expertise will be most effective. It aims to improve Earth observation monitoring systems and strategies, including actions towards harmonization and innovation, to generate common solutions to many shared information technology and data related challenges, to harmonize policies for access and provide strategies for knowledge transfer amongst RIs. ENVRIPLUS develops guidelines to enhance trans-disciplinary use of data and data-products supported by applied use-cases involving RIs from different domains. ENVRIPLUS coordinates actions to improve communication and cooperation, addressing Environmental RIs at all levels, from management to end-users, implementing RI-staff exchange programs, generating material for RI personnel, and proposing common strategic developments and actions for enhancing services to users and evaluating the socio-economic impacts. ENVRIPLUS is expected to facilitate structuration and improve quality of services offered both within single RIs and at pan-RI level. It promotes efficient and multi-disciplinary research offering new opportunities to users, new tools to RI managers and new communication strategies for environmental RI communities. The produced solutions, services and other project results are made available to all environmental RI initiatives, thus contributing to the development of a consistent European RI ecosystem.;14998034,25;14683534,25;H2020-INFRADEV-1-2014-1;RIA;HELSINGIN YLIOPISTO;FI;"EUROGOOS AISBL;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UNIVERSITA DEL SALENTO;ISTITUTO NAZIONALE DI GEOFISICA E VULCANOLOGIA;EUROPEAN MOLECULAR BIOLOGY LABORATORY;CINECA CONSORZIO INTERUNIVERSITARIO;EURO-ARGO ERIC;FORSCHUNGSZENTRUM JULICH GMBH;CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY;THE UNIVERSITY OF EDINBURGH;ILMATIETEEN LAITOS;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;Goeteborgs Universitet;UNIVERSITETET I TROMSOE;Euro-Mediterranean Seismological Centre;KOBENHAVNS UNIVERSITET;EISCAT SCIENTIFIC ASSOCIATION;STICHTING EGI;UNIVERSITAET BREMEN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;CONSIGLIO NAZIONALE DELLE RICERCHE;NORSK INSTITUTT FOR LUFTFORSKNING;NORGES FORSKNINGSRAD;UMWELTBUNDESAMT GMBH;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER;CONSORCIO PARA EL DISENO, CONSTRUCCION, EQUIPAMIENTO Y EXPLOTACION DE LA PLATAFORMA OCEANICA DE CANARIAS;LUNDS UNIVERSITET;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL;MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM;DEUTSCHES KLIMARECHENZENTRUM GMBH;CARDIFF UNIVERSITY;UNIVERSITEIT VAN AMSTERDAM;UNIVERSITA DEGLI STUDI DELLA TUSCIA;NATURAL ENVIRONMENT RESEARCH COUNCIL";"BE;UK;IT;DE;FR;FI;SE;NO;DK;NL;AT;CH;ES"; 194940;654155;LIMB NETWORKS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Network Analysis of Musculoskeletal Evolution and Modularity during the Fin-to-Limb Transition;15/08/2015;14/08/2018;;"The fin-to-limb transition was a major milestone in the history of life that shaped the morphology and remarkable biodiversity of land vertebrates. A central question in vertebrate evolution is how the various anatomical parts of limbs evolved semi-autonomously (modularity) while still growing and adapting in coordination (integration). The main goal of this project is to unravel (i) the evolutionary changes in modularity of the musculoskeletal system that occurred during the evolution from fins to limbs and (ii) how these newly acquired modular organizations facilitated the evolution of different morphologies for the forelimb and hindlimb. To this end, we will evaluate the modularity of limbs and the strength of topological integration among modules by using an innovative approachanatomical network analysisbased on the topological relations that anatomical parts establish among them; these anatomical relations are embodied in network models and quantified globally using sophisticated algorithms from Graph Theory. We propose a multidisciplinary combination, for the first time, of (i) new data on fin/limb muscle anatomy in extant species, (ii) reconstruction of muscle attachments in extinct forms, and (iii) the use of innovative tools such as Anatomical Network Analysis to identify morphological modules and quantify their integration within a phylogenetic context. The results of this unique and transformative project have the potential to revolutionize our understanding of limb evolution during the fin-limb transition. The training in gross anatomy, imaging techniques, and reconstruction of muscles in fossils by the leading researchers involved in this project will foster the development of the candidate Fellow as an independent and innovative frontline researcher in theoretical, evolutionary, and comparative biology in the EU.";251857,8;251857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;THE ROYAL VETERINARY COLLEGE;UK;;; 194810;652707;CommBeBiz;SIGNED;H2020-EU.3.2.;ISIB-08b-2014;H2020;CommBeBiz - Communicating and Bridging BioEconomy Research to Business;1/03/2015;28/02/2018;;Communicate and Bridge BioEconomy Research to Business The overall objective of the CommBeBiz project is to contribute to the improvement of sustainable living conditions through the most effective and responsible use of our biological resources. This will be achieved through designing, delivering, assessing & evaluating a Pilot scheme (BeBizPilotPlan), that provides tailored and targeted support and co-ordination activities across all Member States. The Pilot will bring KBBE funded research projects in FP7 and Horizon2020 programmes together with bioeconomy research, knowledge transfer, social innovation, policy development and communication experts, SMEs and entrepreneurs to drive innovation and exploitation faster for the environmental good and commercial benefit. The full results of the BeBizPilotPlan will be published in the BeBizBlueprint. The project will use a tailormade approach to the segments of the bioeconomy : agriculture, fisheries, food, forestry and biotechnology. CommBeBiz will work collaboratively on the FP7 database with 'Allied Projects' BioLinx and ProBio utilising the Heads of Agreement document agreed between us (July 2015).;1695091,25;1672591;H2020-ISIB-2014-1;CSA;MINERVA HEALTH & CARE COMMUNICATIONS LTD;UK;"EUROPEAN BUSINESS AND INNOVATION CENTRE NETWORK AISBL;PRACSIS SPRL;TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY";"BE;IE"; 194758;651947;SWH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Demonstration of a Binary-Logic Hybrid Transmission for Heavy-Duty Vehicles;1/10/2014;31/03/2015;;"'A vehicle powertrain includes the engine and transmission. In the segment of heavy-duty vehicles (>16 tonnes) automatic transmissions include a torque converter to engage/disengage the transmission and the combustion engine in gearshifts.
SAPA OPERACIONES has developed a new technology of automatic transmissions for heavy-duty vehicles called 'Binary Logic' without torque converter, which bases its operation in clutches and planetary gears trains. This technology is characterized by high number of gears (24) and high efficiency (90-92%).
Although high performance is achieved due to the high number of gears and gearshift quality, there are two gear shifting in which a power interruption is given(13, 21). To solve this problem and improve the performance, a hybrid module has been incorporated to the Binary Logic transmission. This hybrid transmission is called SWH. The following improvements have been obtained: Gearshift without interruption of power in all gears, performance over 96% and new operating modes (up to 7).
Hybrid transmission prototype has been successfully validated in specific test-bench (relevant environment) in which operating conditions have been simulated for a vehicle of 40 tonnes and 500 horsepower (hp).
The overall objective of this project is the demonstration of the final configuration of the hybrid transmission in a real vehicle to confirm that it meets design specifications and requirements of the application in real operating conditions. Demonstration vehicle characteristics are: 40 tonnes, 500 hp, 4 axes and 8x8 configuration.'";71429;50000;H2020-SMEINST-1-2014;SME-1;SAPA OPERACIONES, S.L.;ES;;; 194755;651848;HIPINDMOULD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Optimized Industrial HIPIMS system for coating Plastic Injection Moulds;1/10/2014;31/03/2015;;"In recent years an innovative magnetron sputtering technique named high power pulsed/impulse magnetron sputtering (HPPMS/HIPIMS) has emerged. It is characterized by a high degree of ionization of the sputtered material which makes it a very attractive deposition technique for enhancing and tailoring coating properties. Extremely dense, hard, well adherent and smooth coatings are obtained.
However, after fourteen years of developments, the real up-scaling and industrialization of this promising technology has not been achieved. The main problem is the mistaken assumption based just on including new HIPIMS power supplies into conventional sputtering systems.
This project aims to develop new HIPIMS deposition equipment capable to control process parameters (magnetic field strength and unbalance and pulsing configuration) in order to demonstrate that process-designed HIPIMS for specific application can result in superior coatings.
The target market for the developed coatings is the plastic injection moulding sector where there are high demands on surface quality of moulds. The main degradation mechanisms involved are adhesion, abrasion and corrosion of the surface; moreover, low adhesion of the plastic melt is necessary for reduction of release forces. HIPIMS technology offers outstanding advantages with respect to conventional coating technologies currently applied on moulds (PVD and electroplating) offering optimized performance against corrosion, sticking and wear.
This project gives FLUBETECH the opportunity to evaluate the requirements and benefits (both technical and economical) that the launch of an optimized concept of HIPIMS, repetitive and easy to scale-up, will entail for them. Phase 1 of this project will assess the technical feasibility and commercial potential of the breakthrough innovation that Flubetech wants to exploit and commercialize. The outcome of this study will be a detailed business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;FLUBETECH S.L.;ES;;; 194749;651752;SEAMETEC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Smart Efficient Affordable Marine Energy Technology Exploitation using Composites;1/10/2014;31/03/2015;;"The SEAMETEC project aims to develop smart, efficient tidal-turbine blades and offshore wind-turbine blade structures at an affordable cost. The strategic objective is to increase the availability of secure, low-cost, low-carbon electricity from ocean and offshore energy. These objectives will be achieved by using a novel, but commercially proven, patented, composites manufacturing process and by adding sensor technology that reduces maintenance costs and improves reliability.
The project will be delivered by ireComposites in partnership with EnerOcean, two companies with excellent track records in managing European projects and developing new technologies. EnerOcean has performed technology- and resource-quantification studies on a wide range of tidal technologies and offshore wind. ireComposites has commercialised a novel technology for manufacturing wind-turbine blades.
The project will play an important role in creating a new European industry the production of tidal stream turbines while also giving Europe a competitive advantage in offshore wind. Offshore wind is an established multi-billion euro market. Tidal stream energy is an emerging market that will create up to 120GW of electricity and a 400bn industry. The SEAMETEC partners will access these markets by collaborating with Suzlon (a leading global wind OEM) and Marine Current Turbines (a Siemens business and key player in tidal energy).
The project is a game-changing innovation for tidal energy: it will result in reliable, cost-efficient blades, without which the aggressive launch of tidal arrays may not proceed. It will stimulate the innovation potential of SMEs for a low-carbon and efficient energy system (SIE-01-2014-1) and strongly contribute to the Horizon 2020 Societal Challenge Secure, Clean and Efficient Energy. The two collaborating SMEs will develop clean, affordable technology solutions that increase security of supply of electricity, protect the environment and grow the economy.";71429;50000;H2020-SMEINST-1-2014;SME-1;EIRECOMPOSITES TEORANTA;IE;EnerOcean S.L.;ES; 194826;652986;STEMCELLTRACK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Assessment of Global and Regional Cardiac Functional Improvements in a Murine Model of Myocardial Infarction following Stem Cell Treatments;1/07/2015;30/06/2017;;"Cardiosphere-derived stem cell (CDC) therapy for myocardial infarction (MI) has been shown to elicit moderate beneficial effects. Research currently focuses on improving CDC administration, retention and efficacy. This proposal aims to develop Magnetic Resonance Imaging (MRI) and engineering tools to facilitate this research. Specifically, microinjection of fluorine-19 labeled CDCs will allow for MRI tracking and quantification in vivo. Non-invasive global and regional cardiac function measurements will assess efficacy of stem cell (SC) therapy. Parallel to these studies will be an independent design, synthesis, use and evaluation of fiber-enriched scaffold. The anticipated impact will be multifaceted, including the study of cardiac function in disease, and the potential applicability of generated results with cutting edge SC regenerative technologies in heart failure and prominent cardiomyopathies. Research efforts will be stimulated in manufacturing processes for scaffolds, cardiac functional assessment post-injection of SCs, and validation of their homing, engraftment and viability using cellular tracking methods.
Through a personalized career developments plan, the fellowship will allow training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing his scientific, managerial and leadership qualities. Overall, the short-term objective is the advancement of the researchers career in science and the broadening of his scientific horizons. The long-term objective is to establish the researcher as an independent investigator, advancing the field as a chair of a Biomedical Engineering Department.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 195068;655204;EasyEBC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Easy-to-Implement Energy-Based Control Design for Systems of Conservation Laws;1/09/2015;31/08/2016;;"Secure, clean and efficient energy as well as resource efficiency are major societal challenges formulated in the EU Horizon 2020 Framework Programme. Many subsystems in energy, production and process industries are systems of conservation laws and their efficient operation relies on precise modelling and feasible control design. The port-Hamiltonian approach, developed in a vibrant European research community with the project supervisor as one of the leading figures, uses energy as the key argument for modelling and control of interconnected, nonlinear multi-physics systems, including systems of conservation laws.

The aim of EasyEBC is to develop easy-to-handle energy-based control design procedures for nonlinear systems of conservation laws in the port-Hamiltonian framework. Linear and nonlinear methods from mathematical control theory of finite- and infinite-dimensional systems will be applied for analysis and control synthesis, e.g. semi-group theory, discretization techniques, and energy shaping. The mathematics will be masked behind a user-friendly frontend that offers transparent tuning criteria for the closed-loop dynamics. Bridging the gap between mathematical complexity and easy applicability of the design tools is the main challenge of the project.

The capacity of the renowned supervisor, the application examples at the secondment partners, such as chemical and thermodynamic processes or energy-efficient building refrigeration, and the fellows experience in applying nonlinear energy-based control are essential for the scientific success of the project. As a long-term impact, EasyEBC will contribute to making nonlinear model-based control more accessible to engineers beyond academia.";92538;92538;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITE CLAUDE BERNARD LYON 1;FR;;; 195123;655515;UFOX;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unveiling complexity in Functional hybrid OXides;25/05/2015;24/05/2017;;The purpose of this research project is to get a deeper understanding of the mechanisms and the fundamental interactions that control the formation of electronic ordered phases and the competition between different phenomena in 4d and 3d-4d hybrid transition metal oxides (TMO). Investigation of 4d materials, proposed here, provides new challenges and opportunities they share some common features with 3d systems which stem from electron correlations, but have in addition subtle sensitivity of the electronic states to the lattice structure, effective dimensionality and, most importantly, to relativistic effects due to stronger spin-orbit coupling. The aim of the project is to exploit the class of 4d perovskite ruthenium oxides together with different 4d-3d families of doped materials as a platform for exploring in a controlled way the interplay between correlations, dimensionality and spin-orbit effects when moving from 4d to 3d oxides. Doping a 4d host with 3d impurities might be extremely effective in tuning valence, spin and orbital characteristics and, in turn, the macroscopic physical properties of bulk and layered systems. An ultimate goal is to exploit the variety of physical phenomena inherited in these classes of materials to design interfaces and heterostructures which can show properties at the nanometer scale that are qualitatively different from their single building blocks, thus allowing to engineer novel functionalities. Such a rich scenario can open the route to the fabrication and design of systems where novel and multiple functionalities are nano-integrated on the same chip. The key challenge of the present project is, then, both to unveil the complexities due to the interplay between the dimensionality and the spin-orbital-charge-lattice degrees of freedom and to disentangle them to get insight into the nature of the ordered states and the physical phenomena in 4d-3d systems, as well as in 4d-3d oxide interfaces and heterostructures.;180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 195108;655424;Inflammafish;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cross-talk between inflammation and autophagy in tuberculosis;18/01/2016;17/01/2018;;The increasing occurrence of multidrug-resistant Mycobacterium tuberculosis strains makes tuberculosis (TB) a key priority for infectious disease research. Inflammation and autophagy are two fundamental processes critical to TB pathogenesis. Accumulating evidence shows that TB disease is worsened by deregulation of the inflammatory response. On the other hand, autophagy has recently emerged as a crucial host defence mechanism. Autophagy counteracts the ability of mycobacteria to survive inside host cells and targets them for degradation. Autophagy is also thought to control the inflammatory response. However, the interaction between inflammation and autophagy in host defence against TB remains unclear. The aim of my proposal is to use the well-established zebrafish model of TB to gain insight into this key question. Recently, the host laboratory discovered that the DNA damage-regulated autophagy modulator (DRAM1) protects against TB in the zebrafish model. They also implicated this important autophagy regulator in inflammation, as it strongly affects expression of interleukin-1beta (IL1B). I have specific expertise in studying IL1B-mediated inflammation in zebrafish. Thus the proposed project will be a great synergy between me and the host laboratory, which is leading in zebrafish infectious disease research. I will determine how modulation of autophagy or manipulation of IL1B levels reciprocally influence each other during TB disease. The zebrafish model provides excellent tools to visualize these processes in vivo. Furthermore, I will take advantage of the hosts expertise in RNA sequencing and proteomics to study genome-wide effects of autophagy modulation on the inflammatory response. A secondment will allow me to compare results in the TB model with a damage-induced inflammation model. The project will provide new insights into regulatory pathways that could potentially be intervened in treatment of TB or other inflammatory diseases with common characteristics.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITEIT LEIDEN;NL;;; 194959;654294;TentaclesOfVenom;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unravelling the enigmatic origin of venom secreting cells in sea anemone;1/05/2015;30/04/2017;;"Evolution of venom, natures most complex cocktail, has underpinned the predatory success of venomous animals. Till date, research on venom has mainly focused on how genes encoding them evolve, and our knowledge regarding the evolutionary origin of venom-secreting cells (VSCs) and their secretions, has been limited. Understanding how venom and VSCs evolve in cnidarians - one of the simplest and probably the first venomous animals, such as sea anemones is not only fascinating as it sheds light on the evolution of their ancient venom-system, but may also be instrumental in the development of efficient nematocyte (stinging-cells) based drug-delivery tools. Identifying variation in venom-composition and sites of expression across various developmental stages and between the sexes (gender-specific expression) is also an understudied topic. The former is particularly intriguing in sea anemones, as their larval stages do not feed and yet synthesize toxins. Hence, in this project I propose to: trace the evolutionary origin of known VSCs (nematocytes and gland cells) in the starlet anemone, Nematostella vectensis, by constructing transgenic reporter lines; characterize venom-secretomes of VSCs using Fluorescence Assisted Cell Sorting (FACS) to determine the contribution of each VSC towards the venom arsenal; examine variation in venom-profiles and expression sites across the developmental stages and between the sexes using omics technologies, in situ hybridization and immunostaining; test the biochemical activities (pharmacological assays) of the major and novel toxins identified; and examine the phylogenetic histories and the molecular evolutionary regimes of the major sea anemone toxins to understand the recruitment of genes into the envenoming function in one of the first venomous animals.";182509,2;182509,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE HEBREW UNIVERSITY OF JERUSALEM;IL;;; 194740;651630;REBOOT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Retrofit all-Electric Bus for reduced Operator Operating costs in urban Transport (REBOOT);1/11/2014;30/04/2015;;"The REBOOT project aims to significantly improve the competitiveness of European urban bus operators through the development of a retrofit all-electric drive system that replaces diesel engines. The objectives of our project include:

To develop a retrofit all-electric drive system, battery and recharger pack for an 18 tonne bus that weighs less than 2.2 tonnes (the weight of a diesel drive) with the capacity to travel 160km
A final system price of 120,000 that delivers a payback to the operator within 3 years
To deliver an 80% reduction in fuel operating cost for bus operators
In Phase 1, our objectives include:
Conduct market sounding activities with at least 10 organisations comprising of customers, regulators and industry experts
Identify and establish strategic partnerships with at least 3 European industry partners in our value chain and 2 research institutions capable of enhancing the development and commercialisation of REBOOT
Identify and secure at least 1 location and operator for the pilot trial / demonstration of REBOOT
Evaluate an initial technology concept design using a design simulation package
Conduct a comprehensive review of the IP landscape and identify management strategies";71429;50000;H2020-SMEINST-1-2014;SME-1;MAGNETIC SYSTEMS TECHNOLOGY LIMITED;UK;;; 194849;653331;eCAIMAN;SIGNED;H2020-EU.3.4.;GV-1-2014;H2020;Electrolyte, Cathode and Anode Improvements for Market-near Next-generation Lithium Ion Batteries;1/05/2015;30/04/2018;;"The success of electric vehicles in the mass market depends on the development of high-energy batteries at a competitive price. The research efforts of the past decade have continuously improved the energy densities of batteries, yet electric vehicles have only gradually made their way into the market. A combined surge in both consumer demand and industrial push is now on the verge of prompting a significant market uptake.

eCAIMAN will develop a more powerful battery by modifying and improving individual components and technologies to result in a significant overall improvement of the cell. Key innovations include a 5V high- voltage spinel, a high- capacity composite anode, and a stable high- voltage electrolyte. Their cumulative effect will improve total cell capacity by at least 20%.

eCAIMAN will not develop high risk / high gain components, due to the higher the risk of failure. This will ensure the success of the project and deliver a market- near product, while at the same time achieving the goals of the call.

eCAIMAN scale-up is designed with existing European production technologies and inexpensive materials mined in Europe, thereby reducing the final battery price. The battery is developed in collaboration with large European light, medium and heavy duty vehicle manufacturers, allowing eCAIMAN to address a broad scope of real end-user demands.

eCAIMAN will develop a truly European high-performance battery ready for implementation in the global market.";6126698,75;5807244,5;H2020-GV-2014;RIA;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;AT;"SAMSUNG SDI BATTERY SYSTEMS GMBH;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;EUTEMA GMBH;CENTRO RICERCHE FIAT SCPA;PE CEE NACHHALTIGKEITSBERATUNG & SOFTWARE VERTRIEBS GMBH;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;VOLVO TECHNOLOGY AB;LITHOPS SRL;ARKEMA FRANCE;PIAGGIO & C S.P.A.;IMERYS GRAPHITE & CARBON SWITZERLAND SA;RISE RESEARCH INSTITUTES OF SWEDEN AB;POLITECNICO DI TORINO;FUNDACION CIDETEC;MAGNA STEYR BATTERY SYSTEMS GMBH & CO OG";"AT;EL;IT;FR;SE;CH;ES"; 195053;655137;AUDICON;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Neural mechanisms of spectral context effects on auditory processing;1/03/2015;28/02/2017;;"We perceive the outside world through different senses which we see as recording devices that provide us an accurate representation of reality. Nevertheless, how a sound is heard or a light is seen depends on the context in which they occur. How well we understand speech can greatly vary depending on the presence of other sounds. For instance, a single tone in a complex sound mixture can pop out if it is preceded by a sound with certain properties. This effect is thought to be fundamental in helping people to efficiently detect novelty in a stream of acoustical information. In other situations our perception can fool us, like when we hear sounds that are not there. Someone will perceive a phantom tone after having listened to a certain synthesized stimulus. This phenomenon is related to tinnitus -the perception of a permanent sound, a pathology that debilitates 2% of the population. While those effects are well documented in human psychology, where and how they originate in the brain is currently not known. Our goal is to perform in vivo intra-cellular recordings in the mammalian auditory system to seek the neural mechanisms underlying the effects of context in auditory processing. Beside the fundamental importance of relating perception to neural processing, this research could lead to a better understanding of the mechanism underlying tinnitus induction.

Advancing the knowledge on brain processing is critical for European excellence. The results could serve medical research, a priority for the EU. The main research training objective is managing the challenging technique of patch clamp in vivo in which the host lab has expertise. This top-notch technique will complete the applicants scientific armentarium and make him very competitive in the multidisciplinary field of neuroscience. After this project the applicant will start his own team. The training objectives will thus focus on management and teaching/supervision skills.";172800;172800;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;;; 194743;651658;iMoHEALTH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;iMoHEALTH: A pan-national collaborative analytics platform for the exploration of population health.;1/10/2014;28/02/2015;;"The objective of the IMoHEALTH project is to develop a cloud-based analytics platform for population health data. It will allow users to explore and analyse population health data through an interactive and easy to use interface.

Healthcare data analysis has become an integral part of public health policy making, medical research, the development of new treatments and medical innovations. Governments, pharmaceutical industries, insurance companies, medical research groups, hospitals, etc., increasingly use population-based healthcare data as a critical support to both research and decision-making. Citizens are also increasingly keen to learn about the distribution and outcome of conditions which they may be suffering from. However, an affordable, user-friendly platform that brings together population health data from multiple sources and enables it to be easily presented and mined for this wide range of purposes does not currently exist. The iMoHEALTH platform will meet this need.

The iMoHEALTH platform will use a novel technology to provide easily accessible self-service healthcare analytics to all members of the healthcare and research communities. It will be of use to health care policymakers and commissioners keen to ascertain the needs and health outcomes of their communities; medical research communities wishing to explore the characteristics and outcomes of specific cohorts and conduct a wide range of research; pharmaceutical companies, medical device manufacturers and other industry player wishing to explore their market; and private citizens wishing to explore the health landscape.

The end product of the feasibility study will be a realistic business plan for exploitation of the novel IMoHEALTH technology. This will include market opportunity (size, growth, needs), value proposition, commercialization strategy, IP strategy technology/solution description, and financial projections.";71429;50000;H2020-SMEINST-1-2014;SME-1;FACE RECORDING AND MEASUREMENT SYSTEMS LTD;UK;;; 194725;651441;DeReco;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Feasibility Study on Decentralised Heat Recovery;1/10/2014;28/02/2015;;"Despite a continued depletion of natural resources, ongoing increases in expenditures on energy and tighter legal constrains with regards to emission targets, more than half of the energy currently used in industrial plants, processes and engines all over the globe is wasted as residual heat or waste heat into the environment.
En3, a young technology company, founded in 2009 in Mecklenburg-Western Pomerania, Germany, has developed an expansion device for small scale Waste Heat Recovery systems (WHR-systems). Small scale means a net AC power rating of the WHR-system from about 1 to 50 kW.
EN3s WHR-system is based on the Clausius Rankine Cycle (CRC) or alternatively on the Organic Rankine Cycle (ORC) technology and can substantially improve the efficiency of industrial processes, engines and facilities. They lower the primary energy consumption, improve the efficiency of engines and processes, reduce emissions and protect the environment and resources.
The great advantage of the technology is the flexibility in terms of the heat source. In principle WHR-systems can be adapted to different kinds of heat sources. Above-average market potential for the environmentally friendly and CO2 neutral electricity and heat production is identified for waste heat delivered from exhaust gas of combustion engines. Further applications are seen in the power generation through biomass combustion as well as in the geothermal and solar thermal energy generation.
The objective of the overall innovation project (phase one to three) is to develop and commercialise EN3s small scale WHR-technology.
The objective of this feasibility study (phase one) is an analysis of the market for EN3s small scale WHR-systems in the EU leading to an elaborated business plan showing entry and growth markets in Europe and outlining a clear plan of ENs path forward - both financially and technically. The primary objective of the feasibility study is to identify the best entry market in the EU.";71429;50000;H2020-SMEINST-1-2014;SME-1;EN3 GMBH;DE;;; 194834;653194;RDA Europe;SIGNED;H2020-EU.1.4.1.3.;EINFRA-3-2014;H2020;Research Data Alliance - Europe 3;1/09/2015;28/02/2018;;The Research Data Alliance (RDA) is rapidly building the social and technical bridges that enable open sharing and re-use of data on a global level. RDA/Europe - the European plug-in to the global Research Data Alliance activities will ensure that European research, industrial, e-infrastructure and policy stakeholders are all aware of its achievements, engaged with and actively involved in the global RDA activities and will advance the use of its results. European domain scientists and data scientists are involved in and driving a series of working and interest groups, generating first results of RDA and this momentum should be maintained and even increased. A collaborative web platform, currently under strong development, is widely used by the RDA members and coordinating administration. RDA Europe will look for innovative ways of facilitating the take-up and implementation of RDA outputs in Europe, both in academia and industry, and will continue to develop and maintain the RDA web-based collaboration framework. Further steps will be taken in steering, planning and implementing the sustainability of RDA through a legal entity, established in Europe, and investigating the most appropriate business models for long term sustainability. This RDA/Europe proposal will mainly build on the successful consortium of the previous years but strengthen its anchoring at policy, scientific and industrial uptake to drive forward RDA Europe objectives that are all grounded in technological excellence and innovation and have clear international ties. RDA Europe partners are very actively involved in the strategic planning, implementation, marketing & communication of RDA through the governance bodies of RDA.;3999187,5;3999187,5;H2020-EINFRA-2014-2;CSA;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;"NATIONAL LIBRARY OF IRELAND;CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY;ASSOCIATION OF COMMONWEALTH UNIVERSITIES;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;ATHENA RESEARCH AND INNOVATION CENTER IN INFORMATION COMMUNICATION & KNOWLEDGE TECHNOLOGIES;ROYAL IRISH ACADEMY;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;CONSIGLIO NAZIONALE DELLE RICERCHE;CAP DIGITAL PARIS REGION;TRUST-IT SERVICES LIMITED";"IE;FI;UK;ES;EL;FR;IT"; 194846;653289;DARWIN;SIGNED;H2020-EU.3.7.;DRS-07-2014;H2020;Expecting the unexpected and know how to respond;1/06/2015;31/05/2018;;"In recent years crises and disasters (Eyjafjallajkull and Deepwater Horizon 2010, Fukushima Daiichi 2011) have made it obvious that a more resilient approach to preparing for and dealing with such events is needed. DARWIN will improve response to expected and unexpected crises affecting critical infrastructures and social structures. It addresses the management of both man-made events (e.g. cyber-attacks) and natural events (e.g. earthquakes).

The main objective is the development of European resilience management guidelines. These will improve the ability of stakeholders to anticipate, monitor, respond, adapt, learn and evolve, to operate efficiently in the face of crises. Guidelines will be presented in formats for easy usage and maintenance to avoid them being dust-collectors on a shelf. To enable dynamic, user-friendly guidelines the project will adapt innovative tools (e.g. serious gaming, training packages), test and validate the guidelines, and establish knowledge about how organisations can implement guidelines to improve resilience.

A multidisciplinary approach is applied, involving experts in the field of resilience, crisis and risk management, social media and service providers in the Air Traffic Management and health care domains. To ensure transnational, cross-sector applicability, long-term relevance and uptake of project results, a Community of Crisis and Resilience Practitioners (CoCRP) will be established, including stakeholders and end-users from other domains and critical infrastructures and resilience experts. The CoCRP will be involved in an iterative evaluation process to provide feedback on the guidelines.

The target beneficiaries of DARWIN are crisis management actors and stakeholders responsible for public safety, such as critical infrastructures and service providers, which might be affected by a crisis, as well as the public and media.

The project duration will be 36 months, requesting financing of 4.9M.";4998896,25;4998896,25;H2020-DRS-2014;RIA;STIFTELSEN SINTEF;NO;"ENAV SPA;DEEP BLUE SRL;BEN-GURION UNIVERSITY OF THE NEGEV;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;C.C.I.C.C. LIMITED;OSTERGOTLANDS LAN;TOTALFORSVARETS FORSKNINGSINSTITUT;ISTITUTO SUPERIORE DI SANITA";"IT;IL;DE;IE;SE"; 194734;651542;I-Fusion;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Innovative FUel Sensor for engIne OptimisatioN;1/11/2014;30/04/2015;;"'The environmental emissions impact of transport is currently a major concern and has to be minimized at a world-wide level (Carbon footprint, NOx, Particulates, Soot). In order to meet the '20-20-20' targets, greenhouse gas emissions reduction in EU and improvement in the EU's energy efficiency has to be performed. To do so, one way to achieve this goal is to optimize fuel consumption by proposing technologies and practices.
While there is huge variation in fuel compositions placed on the international market, car Engine Electronic Control Units (ECU) are built and calibrated with only one specific reference fuel. This universal calibration implies safety margins leading to penalties in terms of CO2 and other pollutant exhaust emissions in real conditions.
I-FUSION project objective is to develop a Fuel Quality Sensing (FQS) technology, to be installed on-board vehicles equipped with thermal engines. This sensor will provide real-time information on fuel composition to the ECU, giving the opportunity to adapt all Engine actuators (injection, Exhaust Gas Recirculation) in order to reduce both consumption and CO2 emissions by up to 5% and to reduce pollutant emissions by up to 20% at source.
The project is leaded and composed by an innovative French SME, SP3H, which develops new technologies focused on the profiling of fuel molecular structure for the control and reduction of emissions of carbon dioxide and other pollutants.
SP3H will conduct a feasibility study (phase 1) to prove the technical compatibility with the automotive application by an endurance test in operational environment (more than 100 000 km). Associated to the business data, the phase 1 will provide all the information necessary to the next phases.'";71429;50000;H2020-SMEINST-1-2014;SME-1;SP3H;FR;;; 194942;654164;EHRI;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;European Holocaust Research Infrastructure;1/05/2015;30/04/2019;;"The European Holocaust Research Infrastructure (EHRI) project seeks to transform archival research on the Holocaust. The vision of EHRI is to integrate the data, services and expertise of existing Holocaust infrastructures on an unprecedented scale. It will allow researchers from across the globe transnational and virtual access to the integrated infrastructure, and provide them with innovative digital tools and methods to (collaboratively) explore and analyse Holocaust sources. EHRI will thereby become an indispensable tool for the study of the Holocaust from a pan-European perspective.
EHRI is based on an advanced community that has already achieved a significant co-ordination of its efforts, not least thanks to the activities undertaken during EHRI's first phase. The aim of the second phase is to further expand this community. The EHRI consortium includes 22 partners, spread across Europe and beyond. This consortium, as well as a network of regional contact points, enables EHRI to reach those regions where much valuable Holocaust source material is located, but where access has hitherto been problematic, especially in South-Eastern and Eastern Europe. EHRI includes measures to build capacity in such regions, thereby ensuring that institutions and people across Europe can contribute to, and make use of, the EHRI infrastructure.
EHRI will continue to serve as a 'best practice' model for other humanities projects, and its innovative approach to data integration, management and retrieval will have impact in the wider cultural and IT industries. Although EHRI is geared towards scholarly communities, open online availability of reliable Holocaust material is important for the larger public, as the Holocaust is deeply rooted in the development of European societies. European support for the study of this most traumatic historical event is essential to achieve a comprehensive approach to the history of the Holocaust as a shared European phenomenon.";7969673,75;7969673,75;H2020-INFRAIA-2014-2015;RIA;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;NL;"VALSTYBINIS VILNIAUS GAONO ZYDU MUZIEJUS;ONTOTEXT AD;ZIDOVSKE MUZEUM V PRAZE;THE JEWISH MUSEUM OF GREECE;THE UNITED STATES HOLOCAUST MEMORIAL MUSEUM;BUNDESARCHIV;WIENER WIESENTHAL INSTITUT FUR HOLOCAUST-STUDIEN - VWI;YAD VASHEM THE HOLOCAUST MARTYRS AND HEROES REMEMBRANCE AUTHORITY;FONDAZIONE CENTRO DI DOCUMENTAZIONE EBRAICA CONTEMPORANEA -CDEC - ONLUS;MEMORIAL DE LA SHOAH;KAZERNE DOSSIN MEMORIAAL, MUSEUM EN DOCUMENTATIECENTRUM OVER HOLOCAUST EN MENSENRECHTEN;DOKUMENTACNE STREDISKO HOLOKAUSTU OBCIANSKE ZDRUZENIE;CENTRE D'ETUDES ET DE DOCUMENTATION GUERRE ET SOCIETES CONTEMPORAINES / HET STUDIE- EN DOCUMENTIECENTRUM OORLOG EN HEDENDAAGSE MAATSCHAPPIJ;STOWARZYSZENIE CENTRUM BADAN NAD ZAGLADA ZYDOW;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;ARCHIVES GENERALES DU ROYAUME ET ARCHIVES DE L'ETAT DANS LES PROVINCES;International Tracing Service;MAGYARORSZAGI ZSIDO HITKOZSEGEK SZOVETSEGE TARSADALMI SZERVEZET;ZYDOWSKI INSTYTUT HISTORYCZNY IM. EMANUELA RINGELBLUMA;""INSTITUTUL NATIONAL PENTRU STUDIEREA HOLOCAUSTULUI DIN ROMANIA """"ELIE WIESEL"""""";KING'S COLLEGE LONDON;THE WIENER LIBRARY INSTITUTE OF CONTEMPORARY HISTORY LBG;STIFTUNG ZUR WISSENSCHAFTLICHEN ERFORSCHUNG DER ZEITGESCHICHTE - INSTITUT FUR ZEITGESCHICHTE IFZ";"LT;BG;CZ;EL;US;DE;AT;IL;IT;FR;BE;SK;PL;HU;RO;UK"; 194874;653587;LAW-TRAIN;SIGNED;H2020-EU.3.7.;FCT-07-2014;H2020;Mixed-reality environment for training teams in joint investigative interrogation-Intelligent interrogation training simulator;1/05/2015;30/04/2018;;"Interrogations of suspects in international crime are very difficult and require sophisticated skills, familiarity with different -cultures, laws and methods, and cross-border teamwork. Training law enforcement agents on how to conduct such interrogations is the key to fighting these crimes.

LAW-TRAIN applies an interdisciplinary approach for international criminal interrogations. It will unify the methodology for such interrogations and will develop a distributed mixed-reality gaming platform that will provide training opportunities to teams of international interrogators anytime and anywhere. The platform will include a virtual human suspect that will be interrogated and generate dynamic verbal and body responses. The system will provide tools to generate new characters and new scenarios easily. An intervention agent will follow the training and comment online on the team members performance.

LAW-TRAIN builds on advanced technologies of virtual and augmented reality to allow law enforcement personnel (and translators, lawyers and judges) from different countries located in different sites to conduct a collaborative investigative interrogation of one or more suspects. All the investigators will see each other and work as a team. Each of the trainees will have access to his/her country's the information system and will be able to share this information with the other trainees as required in real criminal investigations.

The investigational database will be directed at international organized crime focusing on international drug trafficking. However, the LAW-TRAIN engine is designed as a generic engine that will enable development of scenarios for other types of illegal activities as well as other cross-border teamwork training.

LAW-TRAIN will be evaluated in an extensive field study with law-enforcement agents from four countries. This will be the first step in the deployment of LAW-TRAIN to fight international organized crime.";5095687,5;5095687;H2020-FCT-2014;RIA;BAR ILAN UNIVERSITY;IL;"OPTIMIZACION ORIENTADA A LA SOSTENIBILIDAD SL;MINISTRY OF PUBLIC SECURITY;MINISTERIO DEL INTERIOR;DE FEDERALE OVERHEIDSDIENST JUSTITIE - LE SERVICE PUBLIC FEDERAL JUSTICE;Inspectoratul General al Politiei Romane;USECON THE USABILITY CONSULTANTS GMBH;INESC ID - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA;Ministrio da Justia;KATHOLIEKE UNIVERSITEIT LEUVEN;COMPEDIA SOFTWARE & HARDWARE DEVELOPMENT LTD";"ES;IL;BE;RO;AT;PT"; 194892;653706;iNEXT;SIGNED;H2020-EU.1.4.1.2.;INFRAIA-1-2014-2015;H2020;Infrastructure for NMR, EM and X-rays for translational research;1/09/2015;31/08/2019;;"Structural biology provides insight into the molecular architecture of cells up to atomic resolution, revealing the biological mechanisms that are fundamental to life. It is thus key to many innovations in chemistry, biotechnology and medicine such as engineered enzymes, new potent drugs, innovative vaccines and novel biomaterials.
iNEXT (infrastructure for NMR, EM and X-rays for Translational research) will provide high-end structural biology instrumentation and expertise, facilitating expert and non-expert European users to translate their fundamental research into biomedical and biotechnological applications.
iNEXT brings together leading European structural biology facilities under one interdisciplinary organizational umbrella and includes synchrotron sites for X-rays, NMR centers with ultra-high field instruments, and, for the first time, advanced electron microscopy and light imaging facilities. Together with key partners in biological and biomedical institutions, partners focusing on training and dissemination activities, and ESFRI projects (Instruct, Euro-BioImaging, EU-OPENSCREEN and future neutron-provider ESS), iNEXT forms an inclusive European network of world class.
iNEXT joint research projects (fragment screening for drug development, membrane protein structure, and multimodal cellular imaging) and networking, training and transnational access activities will be important for SMEs, established industries and academics alike. In particular, iNEXT will provide novel access modes to attract new and non-expert users, which are often hindered from engaging in structural biology projects through lack of instrumentation and expertise: a Structural Audit procedure, whereby a sample is assessed for its suitability for structural studies; Enhanced Project Support, allowing users to get expert help in an iNEXT facility; and High-End Data Collection, enabling experienced users to take full benefit of the iNEXT state-of-the-art equipment.";9999534,25;9999534,25;H2020-INFRAIA-2014-2015;RIA;UNIVERSITEIT UTRECHT;NL;"ETVS LORND TUDOMNYEGYETEM;SYNCHROTRON SOLEIL SOCIETE CIVILE;EUROPEAN MOLECULAR BIOLOGY LABORATORY;CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE;Masarykova univerzita;Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek ziekenhuis;EUROPEAN SPALLATION SOURCE ESS AB;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;WEIZMANN INSTITUTE OF SCIENCE;DIAMOND LIGHT SOURCE LIMITED;ACADEMISCH ZIEKENHUIS LEIDEN;EUROPEAN SYNCHROTRON RADIATION FACILITY;AARHUS UNIVERSITET;FORSCHUNGSVERBUND BERLIN E.V.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;UNIVERSITEIT LEIDEN;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;INSTRUCT ACADEMIC SERVICES LIMITED;OULUN YLIOPISTO;INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA;LUNDS UNIVERSITET;PANEPISTIMIO PATRON";"HU;FR;DE;IT;CZ;NL;SE;ES;IL;UK;DK;FI;PT;EL"; 194719;651272;HOLOSCAN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.7.";DRS-17-2014-1;H2020;Holographic Scanner for Safe Real-Time High Throughput Screening of People and Their Bags;1/12/2014;31/05/2015;;"Art (SoA) detection equipment used for screening of people and their baggage include (1) X-ray screening; (2) X-ray based explosive detection systems (EDS); (3) explosive and chemical trace detection systems (EDT); (4) technologies based on neutron beams; (5) metal detectors and (6) millimeter wave body scanners. None of the current SoA methods is able to offer real-time or even rapid enough safe screening of large numbers of people moving simultaneously towards the entrances of buildings, public transportation or public places and rely on a relatively slow person-by-person screening. We would like to propose a novel approach to high-throughput millimeter wave screening which should allow such real-time screening. HOLOSCAN has the following ambitions in consecutive Phase 1 and Phase 2 SME Instrument projects:

To provide the first commercial HOLOSCAN security scanning system that will allow true real-time scanning of multiple moving persons and their bags which novelty has been verified;
To adapt this HOLOSCAN system to clients needs by varying diode panel size and image resolution at a price below current commercial SoA solutions that can run up to 250,000 per stationary unit;
To offer the clients constant improvement and upgrade of customized image recognition software;
To generate sales in excess of 160Mn in first 5 years post-launch, utilizing a network of distributers and licencees;
To bring ROI for Europe to at least 10,800% given the estimated investment of 1.5Mn in Phase 2 project.";71429;50000;H2020-SMEINST-1-2014;SME-1;INTEGRATED DETECTOR ELECTRONICS AS;NO;;; 195093;655334;HyLITE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Hydrophobic Ionic Liquid Technologies;18/01/2016;17/01/2018;;HyLITE (Hydrophobic Ionic Liquid Technologies) aims to enhance established European strength and capability in the research and development of ionic liquid materials by targeting to production of new ionic liquids with specific, tailored, properties that are technologically functional and environmentally acceptable and can be manufactured from sustainable resources. Optimised atom efficient synthesis will produce new hydrophobic ionic liquids that contain only carbon, nitrogen and hydrogen atoms and so have low environmental impact and can be used as non-polluting extraction solvents in liquid/liquid separations springboarding sustainable innovation within industry and academia.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE QUEEN'S UNIVERSITY OF BELFAST;UK;;; 194932;654119;PARTHENOS;SIGNED;H2020-EU.1.4.1.1.;INFRADEV-4-2014-2015;H2020;Pooling Activities, Resources and Tools for Heritage E-research Networking, Optimization and Synergies;1/05/2015;30/04/2019;;"PARTHENOS aims at strengthening the cohesion of research in the broad sector of Linguistic Studies, Humanities, Cultural Heritage, History, Archaeology and related fields through a thematic cluster of European Research Infrastructures, integrating initiatives, e-infrastructures and other world-class infrastructures, and building bridges between different, although tightly, interrelated fields. PARTHENOS will achieve this objective through the definition and support of common standards, the coordination of joint activities, the harmonization of policy definition and implementation, and the development of pooled services and of shared solutions to the same problems.
PARTHENOS will address and provide common solutions to the definition and implementation of joint policies and solutions for the humanities and linguistic data lifecycle, taking into account the specific needs of the sector that require dedicated design, including provisions for cross-discipline data use and re-use, the implementation of common AAA (authentication, authorization, access) and data curation policies, including long-term preservation; quality criteria and data approval/certification; IPR management, also addressing sensitive data and privacy issues; foresight studies about innovative methods for the humanities; standardization and interoperability; common tools for data-oriented services such as resource discovery, search services, quality assessment of metadata, annotation of sources; communication activities; and joint training activities. Built around the two ERICs of the sector, DARIAH and CLARIN, and involving all the relevant Integrating Activities projects, PARTHENOS will deliver guidelines, standards, methods, services and tools to be used by its partners and by all the research community. It will exploit commonalities and synergies to optimize the use of resources in related domains.";11999711;11999711;H2020-INFRADEV-1-2014-1;RIA;PIN SOC.CONS. A R.L. - SERVIZI DIDATTICI E SCIENTIFICI PER L UNIVERSITA DI FIRENZE;IT;"GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;DIGITAL RESEARCH INFRASTRUCTURE FOR THE ARTS AND HUMANITIES;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;ACADEMY OF ATHENS;Istituto Centrale per il Catalogo Unico delle biblioteche italiane e per le informazioni bibliografiche;FACHHOCHSCHULE POTSDAM;SOCIETA INTERNAZIONALE PER LO STUDIO DEL MEDIOEVO LATINO-S.I.S.M.E.L.ASSOCIAZIONE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;CONSIGLIO NAZIONALE DELLE RICERCHE;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;CLARIN ERIC;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN;KING'S COLLEGE LONDON";"DE;NL;IE;ES;FR;EL;IT;AT;UK"; 194831;653056;EMEHOC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Enriched Minimal Expressivism and Higher-Order Concepts;1/10/2015;30/09/2017;;"One (unum), True (verum), and Good (bonum), the Medieval transcendentals, are concepts that philosophers have always kept at the centre of their concern, as has occurred with logical notions such as therefore, epistemic notions such as knowledge and belief, and deontic notions such as ought. And for good reasons. The meaning of these concepts is complex, and language sciences have needed a sophisticated degree of development to be able to cope with this issue. All these notions encode what we now call higher-order concepts. The defining characteristic of higher-order concepts is that they are predicative notions that have other predicables (including 0-adic predicables, i.e. propositions) as arguments. Logical constants, quantifiers, and alethic, epistemic, and deontic modalities belong to the general class of high-order concepts. EMEHOC aims at developing a unified and comprehensive treatment of higher-order concepts, Enriched Minimal Expressivism, which benefits from the several insights that philosophers have put forward related to some particular sets of them, and also of the latest linguistic proposals on procedural and non-truth-conditional meaning.
EMEHOC will develop the first-ever general theory of higher-order concepts. To date, philosophers and linguists have given some useful insights on them but EMEHOC will be the first to examine their functioning from an interdisciplinary perspective. EMEHOCS impact will reach any areas of knowledge in which accurate discourse and precise argumentation are essential. This includes ethics and political theory, and in general public and scientific uses of language.
EMEHOC will use a collaborative methodology that will contribute to the emergence of new, promising interdisciplinary areas, according to the objectives of the EU Framework Programme for Research and Innovation (Horizon 2020), avoiding duplications and maximizing resources.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 194819;652862;IMPRECSIM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Improving wet plastic recycling through innovative lagrangian particle-fluid simulations;1/06/2015;30/11/2016;;"Wet particle separation is used widely in mineral processing as well as plastic recycling to separate mixtures of particulate materials into further usable fractions due to density differences. Despite its wide usage wet particle separation processes are often attributed to operational problems especially if density differences of the feed material are low. A review of the state of the art clearly indicates that numerical modelling has not yet been applied to wet separation processes due to the lack of applicable numerical schemes. On this background numerical modelling can strongly contribute towards improving the design and process parameters of wet particle separation technologies especially in the field of plastic recycling - improvements have a strong environmental impact such as reduced landfill and lower overall pollution.

The proposed research consists of two parts. The first objective is the development of a novel, fully Lagrangian particle-fluid modelling framework applicable to systems of particles of complex shape in a wet environment. For modelling the particles, the Discrete Element Method (DEM) will be employed. For the fluid part, the Lagrangian Smooth Particle Hydrodynamics (SPH) will be used which enables handling free surfaces and large movements of the fluid, inherently. While unresolved fluid flow around particles is already used in mesh based methods, coupling the DEM and SPH in one computational framework is a challenging task addressed in this project. Thereby, a framework is developed for representing technical scale systems of complex shaped particles in a wet environment for the first time. In the second part of the project, the developed framework will be applied to the modelling of a wet separation process involving a sink-float drum separator for plastic recycling. Both design and operational parameters will be optimized and results exchanged towards technology improvements with interested European companies from the recycling sector.";128595,6;128595,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;RUHR-UNIVERSITAET BOCHUM;DE;;; 195078;655249;3DNCPM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Three-Dimensional Nonlinear Chiral Plasmonic Metamaterials;1/03/2015;28/02/2017;;The proposed project aims at a comprehensive understanding of the processes underlying the nonlinear optical responses of three-dimensional chiral plasmonic metamaterials (3DNCPM). Electromagnetic fields that interact with chiral plasmonic nanostructures result in strong chiroptical effects. Because their optical response is proportional to multiple powers of the enhanced near-field intensity, chiral metal nanostructures also constitute excellent candidates for nonlinear optical materials with new or improved properties. Utilizing advanced nanofabrication technologies, we are able to create complex three-dimensional metallic nanostructures and tailor their spectral response at will depending on the material properties, the nanostructure geometry, and its surrounding. The ability to concentrate light in sub-wavelength dimensions and to locally enhance the strength of the electromagnetic field in a tailored fashion will give us a full understanding of the physics behind the nonlinear optical mechanisms of plasmonics and chirality. Using sophisticated metamaterial designs, we aim at enhancing the nonlinear chiroptical effects and we believe that our work will provide a framework for exploiting the benefits of chiral nonlinear metasurfaces for novel applications, such as plasmonically enhanced mid-IR and THz generation, as well as nonlinear plasmonic sensing.;159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitaet Stuttgart;DE;;; 194811;652745;AUTOOLIGO;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Automated synthesis of S. pneumoniae 7F capsular polysaccharide repeating unit as candidate for conjugate vaccines;1/04/2015;31/03/2017;;"The goal of this project is to develop an automated synthesis of the Streptococcus pneumoniae 7F capsular polysaccharide repeating unit, which is of high interest for synthetic vaccines against this pathogen. This structural motif has never been synthesized yet, not even by traditional solution techniques. Our approach is highly innovative in the application of automated oligosaccharide synthesis, which will make the synthetic procedure more time- and cost-effective.
In the course of the project, a series of orthogonally protected monosaccharide building blocks will be synthesized. The oligosaccharide will be assembled on oligosaccharide synthesizer. Photocleavage in a flow reactor and global deprotection will yield the target molecule. The oligosaccharide will be subjected to bioconjugation with a CRM197 carrier protein to produce conjugate vaccine candidate. This conjugate will be tested for the ability to induce an immune response against S. penumoniae 7F.";159460,8;159460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 194917;653997;PRDM9Recomb;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Evolution of PRDM9 Binding and Genomic Localization of Meiotic Recombination Events;1/05/2015;30/04/2017;;Meiotic recombination is an essential process for sexually reproducing organisms. The appropriate genomic distribution of recombination events is necessary for the accurate transmission of genetic information from one generation to the next. Extensive research has demonstrated that a major determinant of recombination sites in mice and humans is the DNA-binding protein PRDM9. An intriguing feature of PRDM9 is the exceptionally rapid evolution of its DNA-binding domain, which causes enormous variability in the locations of recombination events, even within a single species. To date, our understanding of PRDM9s genome-wide distribution is based largely on its predicted DNA-binding specificity, however, the presence of a predicted consensus motif alone is not a strong predictor of recombination locations. Here, I will test the hypothesis that additional factors act in concert with the rapidly evolving PRDM9 protein to specify sites of meiotic recombination events. I will directly map and compare the genome-wide distribution of PRDM9 in different mouse strains to understand the evolution and principles of its binding. I will also pioneer a single-cell based approach that can distinguish between different classes of recombination events to build a high-resolution genome-wide recombination map to further dissect the role of PRDM9, and to identify additional factors, that shape the recombination landscape.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194927;654039;THOR;SIGNED;H2020-EU.1.4.1.3.;EINFRA-7-2014;H2020;THOR Technical and Human Infrastructure for Open Research;1/06/2015;30/11/2017;;"Five years ago, a global infrastructure to uniquely attribute to researchers their scientific artefacts (articles, data, software) appeared technically and socially infeasible. Since then, DataCite has minted over 3.5m unique identifiers for data. ORCID has deployed an open solution for identification of contributors with over 850,000 registrants in less than 2 years.

THOR will leverage these emerging global infrastructures to support the H2020 goal to make every researcher digital and increase creativity and efficiency of research, while bridging the R&D divide between developed and less-developed regions. We will establish interoperability between existing resources, linking digital identifiers across platforms and propagating attribution information.

We will integrate PID services across the research lifecycle and data publishing workflows in four advanced research communities, and then roll-out core services and service building blocks for the wider community. These open resources will foster an open and sustainable e-infrastructure across stakeholders to avoid duplications, give economies of scale, richness of services and the ability to respond rapidly to opportunities for innovation.

THOR is not just relevant to the EINFRA-7-1024 Call, but will become a pervasive element of the EINFRA family of e-Infrastructure resources over the next 3 years. It will allow data-management and curation services to exploit knowledge of data location and attribution; provide robust and persistent mechanism for linking literature and data; enable search and resolving services and generate incentives for Open Science; deliver provenance and attribution mechanisms to underpin data exchange; and provide minting and resolving services for data citation workflows.

Its impact will enable third-party services, no-profit and commercial, to leverage the scholarly record.";3458250;3456250;H2020-EINFRA-2014-2;RIA;THE BRITISH LIBRARY BOARD;UK;"EUROPEAN MOLECULAR BIOLOGY LABORATORY;MONASH UNIVERSITY;DATACITE INTERNATIONAL DATA CITATION INITIATIVE;ELSEVIER BV;UNIVERSITAET BREMEN;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;PUBLIC LIBRARY OF SCIENCE;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;ORCID EU";"DE;AU;NL;CH;US;BE"; 194806;652671;PROIntensAfrica;SIGNED;H2020-EU.3.2.;SFS-06-2014;H2020;Towards a long-term Africa-EU partnership to raise sustainable food and nutrition security in Africa;1/04/2015;31/03/2017;;"PROIntensAfrica intends to develop a proposal for a long term research and innovation partnership between Europe and Africa, focusing on the improvement of the food and nutrition security and the livelihoods of African farmers by exploring and exploiting the diversity of pathways to sustainable intensification of African agro-food systems. The exploration will include environmental, economic and social externalities along the whole value chains. PROIntensAfrica has the ambition to formulate a research and innovation agenda, identifying the domains in need for further research to realize the potential of African food systems. In addition, PROIntensAfrica will suggest governance mechanisms that are effective in supporting the partnership. Key is the perception that pooling resources is the best way to align existing and initiate new research. This perception follows the policy of the EC, where instruments of joint programming like ERA-NET, JPI and article 185 aim to accomplish synergy and increase the effectiveness of resources. Pooling resources goes beyond the scientific domain and reaches into the policy domain. Consequently, besides being rooted in sound and challenging research, a partnership proposal needs to meet national and international policies to fly. Therefore PROIntensAfrica pay specific attention to engage with the policy domain, as exemplified by the intended creation of a policy support group.

The rationale of the project is that a variety of pathways leads to sustainable intensification of African food systems. Different pathways are advocated in literature. High-input farming systems, for example, contrast with organic farming systems, each with their own supporters and criticasters. It is the conviction of the PROIntensAfrica consortium that moving beyond that debate will open exciting new pathways, and that combining elements of different systems will yield innovative systems that are optimally adapted to specific contexts.";1777873,75;1047005;H2020-SFS-2014-1;CSA;STICHTING WAGENINGEN RESEARCH;NL;"LUONNONVARAKESKUS;Instituto Superior de Agronomia;UNIVERSITY OF GREENWICH;CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC;KOBENHAVNS UNIVERSITET;UNIVERSITE CATHOLIQUE DE LOUVAIN;INSTITUT DE L'ENVIRONNEMENT ET DE RECHERCHES AGRICOLES;TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY;SVERIGES LANTBRUKSUNIVERSITET;UNIVERSITAET FUER BODENKULTUR WIEN;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN;CENTRE FOR COORDINATION OF AGRICULTURAL RESEARCH AND DEVELOPMENT FOR SOUTHERN AFRICA;AGRICULTURAL RESEARCH COUNCIL (ARC);SZENT ISTVAN UNIVERSITY;Norwegian institute of Bioeconomy Research - NIBIO;Forum for agricultural research in Africa;AFRICAN FORUM FOR AGRICULTURAL ADVISORY SERVICES;COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH;INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA;INSTITUTO DE INVESTIGACAO CIENTIFICA TROPICAL;CESKA ZEMEDELSKA UNIVERZITA V PRAZE;THE REGISTERED TRUSTEES OF THE ASSOCIATION FOR STRENGTHENING AGRICULTURAL RESEARCH IN EASTERN AND CENTRAL AFRICA;CONF. RESPONS. RECHER. AGRONOM.AFRIQ. DE L'OUEST & DU CENTRE";"FI;PT;UK;FR;DK;BE;BF;IE;SE;AT;DE;BW;ZA;HU;NO;UG;GH;ES;CZ;SN"; 194794;652601;WINETWORK;SIGNED;H2020-EU.3.2.;ISIB-02-2014;H2020;Network for the exchange and transfer of innovative knowledge between European wine-growing regions to increase the productivity and sustainability of the sector;1/04/2015;30/09/2017;;Building on a methodology for innovation-driven research previously developed and tested, the WINETWORK project has the ambition to stimulate collaborative innovation in the wine sector. The project will implement a methodology that has been successful in promoting demand-driven innovations in previous regional and European projects. This approach is mainly based on the interactions between a network of facilitator agents, several regional technical working groups and one European scientific working group. A participatory approach is used to translate results from science and practical knowledge into technical datasheets that are used to prepare materials adapted to end-users. A bottom-up approach is also used to identify a demand-driven innovation agenda. In the WINETWORK project, the approach will be implemented in ten regions from seven countries representing more than 90% of the EU wine production. The main topic addressed in the network concern the control and the fight against diseases that jeopardise the future production potential of the EU (Grapevine Trunk Diseases and Flavescence Dore). As they represent a threat for the economic viability of the entire sector, these topics have been previously identified as a priority by winegrowers, scientists and decision-makers. As many winegrowers are testing innovative and sustainable approaches to fight these diseases, it is very beneficial to capture these ideas and to share them between EU countries. Innovative practices will be synthesized, tailored and translated to become fully accessible to innovation support services and to winegrowers. The project will then deliver a vast reservoir of existing scientific and practical knowledge related to sustainable vineyard management. It will also provide a methodology that will support all agriculture sectors to enhance innovation-driven research. WINETWORK involves 11 partners of excellence representing the entire innovation chain, from science to farmers.;1999471,75;1999221,75;H2020-ISIB-2014-1;CSA;INSTITUT FRANCAIS DE LA VIGNE ET DU VIN;FR;"A.D.V.I.D. ASSOCIACAO PARA O DESENVOLVIMENTO DA VITICULTURA DURIENSE;MINISTERIUM FUER UMWELT, LANDWIRTSCHAFT, ERNAEHRUNG, WEINBAU UND FORSTEN RHEINLAND- PFALZ;INSTITUTO GALEGO DA CALIDADE ALIMENTARIA;SOCIETA ITALIANA DI VITICOLTURA ED ENOLOGIA;ESZTERHAZY KAROLY FOISKOLA;EUROQUALITY SARL;VINIDEA SRL;INSTITUT ZA POLJOPRIVREDU I TURIZAM USTANOVA;FUNDACION EMPRESA UNIVERSIDAD GALLEGA;UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE;ESZTERHAZY KAROLY EGYETEM";"PT;DE;ES;IT;HU;FR;HR"; 195038;655034;EXPRESSIONARRATION;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Narration, linguistic expression and discourse structure: explorations of orality in Occitan and French;1/04/2016;31/03/2018;;This project is an exploration of the linguistic complexities around the concept of orality, as attested in different expressions of oral narrative in Occitan and French. It will be corpus-based and comparative, looking at a key set of temporal features in narratives collected in a traditional oral setting, in contemporary oral settings and in published literary versions of oral narratives. Crucially, the project seeks to revisit the definition of orality and to contribute to novel conceptual models. Outputs will take the form of peer-reviewed journal articles, a unique digitised Occitan corpus, digital annotation tools, conference papers and an intersectoral workshop. Given the location of this MSCA in Belfast, and the importance of oral storytelling in Irish cultural heritage, an integral part of the project involves public engagement around cultural practice and minorised languages, and the establishment of links between cultural sectors internationally. The supervisors (JCs) expertise both overlaps with, and complements the experienced researchers (MVs) skills, such that the project will be of mutual benefit at both individual and institutional level. In line with MSCA objectives, the experienced researcher will diversify her research skills (theoretical, analytical and digital), will benefit from excellent linguistic, research and professional training, and will enhance her career profile through international and intersectoral mobility.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE QUEEN'S UNIVERSITY OF BELFAST;UK;;; 194926;654038;DecoMP_ECoG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Decoding memory processing from experimental and spontaneous human brain activity using intracranial electrophysiological recordings and machine learning based methods.;1/07/2015;30/06/2018;;"Despite the critical importance of memory for cognitive function and socialization, very little is known about how information is stored for later retrieval and use. Understanding how the human brain maintains and stores information would enhance research on memory dysfunction in degenerative diseases, such as the age-related dementias, which represent a large burden for European society, and could facilitate the development of strategies for improving memory.
The current proposal will use intracranial electrophysiological recordings from the surface of the human brain to investigate encoding, retrieval and consolidation of category-specific information during experimental settings, as well as during spontaneous brain activity. The proposal consists in two parts: first, electrocorticographic (ECoG) data will be acquired at Stanford University, with access to high-quality recordings and modern tools for electrophysiological data analysis. Secondly, machine learning based methodologies will be developed at the Department of Computer Science, University College London (return host) to decode spontaneous brain activity in different vigilance states. Finally, all developed methods will be implemented in an open source software, ensuring the timely dissemination of state-of-the art techniques. The methodological developments considered in this project could provide means for developing computer-aided diagnostic tools for neurodegenerative diseases.";269857,8;269857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;UNIVERSITY COLLEGE LONDON;UK;;; 195063;655172;WOODSofCHANGE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cambium genetics in Arabidopsis and Aspen: basic science meets wood production;1/09/2015;31/08/2017;;"Multicellular organisms require an accurate coordination of multiple growth programs to develop. In plants, the lateral growth is the process by which stems and roots grow in diameter. Lateral growth is a pivotal process for plant development that (i) provides the mechanical stability that plants need to expand their growth and sustain their structures and (ii) brings about large amounts of extremely useful plant biomass, especially in the form of wood in trees. Lateral growth is mediated by a specialised group of stem cells collectively called cambium. Remarkably for such a crucial cell-type for plant development and biomass generation, very little is known about the genetic regulation of cambium. Dr. Agustis lab has identified new strong potential cambium regulators through a novel approach that combines natural variation and Genome-Wide Association Studies (GWAS) in the model plant Arabidopsis thaliana. Based on the sophisticated skills that I acquired in the field of tree genetics and genomics and on the large experience on genomics techniques held in the lab of Dr. Agusti, I present a project that will:
1) Characterise the role of new potential cambium regulators identified in Dr. Agustis lab in Arabidopsis and Aspen trees, using state of the art genetic and molecular techniques.
2) Discover new cambium regulators in Arabidopsis by expanding the natural variation and GWAS approach previously used in Agustis lab.
3) Translate the results obtained through 1) and 2) into the generation of new Aspen varieties (using state of the art techniques on tree genetics and genomics that I have extensively used in the past) with the view of enhancing biomass production in Aspen in the form of wood.
Results will (i) unravel new and fundamental aspects of the genetic regulation of cambium activity, illuminating our general understanding on plant development and (ii) strongly impact on Europe excellence by enhancing our capacity for plant biomass production.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194796;652615;FACCE SURPLUS;SIGNED;H2020-EU.3.2.;ISIB-12a-2014;H2020;SUstainable and Resilient agriculture for food and non-food systems;1/03/2015;29/02/2020;;"The objective of FACCE SURPLUS is to strengthen the European Research Area in support of different integrated food and non-food biomass production and transformation systems, especially by organising, implementing and cofunding with the EU a joint call for transnational research projects on the topic of sustainable and resilient agriculture. As this topic falls within the scope of the Strategic Research Agenda (SRA) of the Joint Programming Initiative on Agriculture, Food Security and Climate Change (FACCEJPI), this ERA-NET Cofund will contribute substantially to the delivery of the FACCEJPI SRA. It will thereby also contribute to the overall EU objective of building the European Research Area through enhanced cooperation, coordination and alignment of national research programmes.
The action FACCE SURPLUS also aims at implementing other joint activities such as organizing workshops, scientific events, clustering of research platforms and infrastructures in the field of food and non-food biomass production and transformation systems, and also additional joint calls without EU cofunding. Launching such joint calls on a regular basis would pave the way to the long term objective of FACCE SURPLUS to establish a self-sustaining joint programme for FACCE-JPI. This will include establishing links with ongoing FACCE-JPI actions as well as related EU and international initiatives. FACCE SURPLUS will also support innovation and value creation from biomass in a sustainable way.
The ERA-NET Cofund instrument is appropriate for FACCE-JPI, since it provides additional incentive to participating countries to engage financially on the field of sustainable and resilient agriculture, but also includes the flexibility to implement further activities to contribute to the establishment of a renewable bioeconomy in the ERA.";15151515,1;5000000;H2020-ISIB-2014-1;ERA-NET-Cofund;FORSCHUNGSZENTRUM JULICH GMBH;DE;"Bundesanstalt fr Landwirtschaft und Ernhrung;MINISTERO DELLE POLITICHE AGRICOLE ALIMENTARI E FORESTALI;THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS;MINISTRY OF AGRICULTURE AND FORESTRY;NEDERLANDSE ORGANISATIE VOOR WETENSCHAPPELIJK ONDERZOEK;Bundesministerium fr Ernhrung, Landwirtschaft und Verbraucherschutz;BUNDESMINISTERIUM FUER BILDUNG UND FORSCHUNG;IDRYMA PROOTHISIS EREVNAS;FONDS VOOR WETENSCHAPPELIJK ONDERZOEK-VLAANDEREN;MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITA' E DELLA RICERCA;AARHUS UNIVERSITET;MAAELUMINISTEERIUM;NORGES FORSKNINGSRAD;FONDS FLANKEREND ECONOMISCH EN INNOVATIEBELEID;NARODOWE CENTRUM BADAN I ROZWOJU;MINISTERIE VAN ECONOMISCHE ZAKEN;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;AGENCE NATIONALE DE LA RECHERCHE;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA;INNOVATIONSFONDEN;AGENTSCHAP VOOR INNOVATIE DOOR WETENSCHAP EN TECHNOLOGIE;FONDS NATIONAL DE LA RECHERCHE SCIENTIFIQUE";"DE;IT;UK;FI;NL;CY;BE;DK;EE;NO;PL;RO;FR;ES"; 194859;653395;ESPRIT;SIGNED;H2020-EU.3.4.;GV-5-2014;H2020;Easily diStributed Personal RapId Transit;1/05/2015;30/04/2018;;"Today, transportation both to/from city-centres and within peri-urban areas, is unsatisfactory in terms of congestion, environmental and societal aspects. To answer identified needs, the Easily diStributed Personal RapId Transit (ESPRIT) project aims to develop a purpose-built, light weight L6 category electric vehicle that can be stacked together to gain space. Thanks to pioneering coupling systems, up to 8 ESPRIT vehicles can be nested together in a road train, 7 being towed for an efficient redistribution of fleets and a smartly-balanced and cost efficient transport system. Within the project, 2 user scenarios are foreseen: a one-way carsharing system within city centres and a last-kilometre personal mobility system to existing public transport infrastructures in peri-urban areas. These will be tested through 3 different geographical use cases (Glasgow, Lyon and LHospitalet de Llobregat near Barcelona).
This innovative transport system concept will be demonstrated to TRL5 though state-of-the-art developments of diverse technological bricks (including vehicle and road train architecture, coupling and guiding systems, kinetic and dynamic behaviour management systems, efficient energy supply and rapid charge battery strategies). To prove the ESPRIT concept, the project will also work on modelling and simulation tools to predict, once ESPRIT vehicles are deployed, the economic, social and environmental benefits as well as key operating strategies.
This concept will incite citizens to use public transport and carsharing solutions rather than their private vehicles leading to seamless intermodal transport, decongestion, significant reduction of noise and air pollution. To reach all stakeholders, the ESPRIT project will not only rely on its technical expertise but also on the knowledge and network of its end user community represented by several partners as well as the Advisor Board which includes carsharing organisations, public authorities and transport operators.";7996591,25;7996591,25;H2020-GV-2014;RIA;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;"RPH S.R.L.;THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;DAVIDSON PETER;TEAM RED DEUTSCHLAND GMBH;VECTOS (SOUTH) LIMITED;KAITEK SRL;FRANCE AUTOPARTAGE;LYON SMART DESIGN;LEADEC ENGINEERING GMBH;PETER DAVIDSON CONSULTANCY LIMITED;CONSIGLIO NAZIONALE DELLE RICERCHE;FONDATION PARTENARIAL MOV'EOTEC;ARTTIC;TECHNICAL STUDIO;KEOLIS;FIRST SOMERSET & AVON LIMITED;AJUNTAMENT DE L'HOSPITALET DE LLOBREGAT;LUXCONTROL SA;FAR-UK LTD";"IT;UK;DE;FR;ES;LU"; 195023;654963;ENSUR4LIFE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;New engineered surfaces for a better life;1/05/2015;30/04/2017;;"Surface anti-condensation and/or anti-biofouling (by surface wettability control) are very interesting and useful properties aimed by industry as they can offer more energy efficient, easy-cleanable or more hygienic products. In the last years, new non-conventional techniques have been developed in order to provide those new functionalities by physical surface modification (avoiding chemical coatings or doping bulk materials). But up to the moment, a technology able to respond to hard industrial requirements as home appliances (i.e. durability, severe boundary conditions, low cost) has not been achieved.
This project will research on bringing functional properties to low-cost materials: anti-condensation for stainless steel and one polymer (PP); and anti-biofilm for two polymers (PP and EPDM). Both properties will be ensured by proper surface wettability control. Two non-conventional surface micro/nanostructuration technologies will be researched: PVD nanorods growing for stainless steel, and Thermal-NIL (Th-NIL) for PP and EPDM.
This is a multidisciplinary project: combining theory, computer simulation and experimental research. Expected results are very promising as for the first time regarding to bibliography, the nanostructuration by PVD nanorods growing will be achieved on Stainless Steel and Th-NIL micro/nanostructuring will be directly performed on PP and EPDM substrates. Those promising results will impact the industry, not only home appliances sector, but also automotive, aeronautic, surgery, etc.
The teamwork composed by BSH with experience in wettability surface control, nano/micromachining and plastics- and Dr. Bobaru experienced in PVD, micro/nanocharacterization and metals- will be complemented by DTU (Denmark academic partner) acting as Th-NIL expert and training Dr. Bobaru. Thus the project is also conceived with multisectorial focus.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;BSH ELECTRODOMESTICOS ESPANA SA;ES;;; 194816;652816;GasOn;SIGNED;H2020-EU.3.4.;GV-3-2014;H2020;Gas-Only internal combustion engines;1/05/2015;31/10/2018;;"In order to realize sustainable mobility in Europe, both urban and long distance vehicles for road transport will have to be significantly more efficient by 2020\ and a considerable contribution will have to come from the energy efficiency improvement of the powertrain. Moreover, together with the progressive efficiency increase coming from the engine technology evolution, the use of Low-Carbon Alternative Fuels, such as Natural Gas, will play a fundamental role to accelerate the process of decarbonization of the transportation sector that in Europe is targeted for the 2050 time horizon. In this context, being well-known the benefits of the Natural Gas Vehicles adoption in Europe, this proposal aims to exploit the main benefits of gas-powered engines developing CNG-only, mono-fuel-engines able to comply with:
post Euro 6 noxious emissions
2020\ CO2 emissions targets
new homologation cycle and Real Driving conditions and simultaneously improving engine efficiency and vehicle performance also with regard to its CNG range capability.

These engines, based on new combustion processes, require also dedicated technological solutions for:
Innovative injection, ignition and boosting system concepts
Advanced exhaust gas aftertreatment system
Detecting the gas-quality and its composition

The results obtained from the experimental activities on the demonstration vehicles and engines will be harmonized and analysed throughout a final overall assessment of the different approaches. The demonstrator vehicles will be assessed in terms of performance and emissions with regard to NEDC, WLTP and under real driving conditions.
Moreover, the final assessment of the vehicles will be certified, as independent testing, by JRC (Joint Research Centre) which will carry out additional measurements in their own testing facilities both on chassis dyno and by means of PEMS (Portable Emissions Measurement System).";23391977,5;16704977,14;H2020-GV-2014;IA;CENTRO RICERCHE FIAT SCPA;IT;"PIERBURG GMBH;POLITECHNIKA POZNANSKA;VOLKSWAGEN AG;AVL LIST GMBH;FEV EUROPE GMBH;RICARDO UK LIMITED;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SCHAEFFLER TECHNOLOGIES AG & CO. KG;CESKE VYSOKE UCENI TECHNICKE V PRAZE;DELPHI AUTOMOTIVE SYSTEMS LUXEMBOURG SA;FORD-WERKE GMBH;RENAULT SAS;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;POLITECNICO DI TORINO;UNIVERSITAT POLITECNICA DE VALENCIA;Continental Automotive GmbH;IFP Energies nouvelles;EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT";"DE;PL;AT;UK;FR;CZ;LU;CH;IT;ES"; 194781;652511;CroDS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;PiggyBaggy the Uber of parcel delivery;1/10/2014;30/04/2015;;"PiggyBaggy is a crowdsourced logistics service allowing, for example, someone shopping in a hypermarket to also safely and easily deliver groceries to his neighbors and get paid for it. It is an efficient, sustainable and affordable transport alternative for home deliveries from retail stores and parcel pick-up points.
Compared to the crowdsourced taxi service Uber, PiggyBaggy is:
1. Used for parcel deliveries instead of people transport
2. Parcels are transported by peer consumers instead of semi-professional drivers
3. Parcels are sent by grocery retail and delivery company partners (high volume) instead of consumers
Our partnering with large retailers and delivery companies allows faster growth for both, because we reduce the cost of delivery for consumers below their 4-7 pain threshold (McKinsey). Our IPR strategy supports the competitive advantages and negotiating power. As a result we will achieve net revenues of 278 million from home deliveries of consumer goods in Europe by 2020 based on Ubers proven business model (assuming 5% market share and 15% transaction margin).
The service pilot with a public library validated 20x cost savings in home deliveries. A Vice President in Finlands largest retail chain and a Vice President in the Finnish postal service have agreed on partnerships to pilot the service with their customers.
This project produces a feasibility study and a business plan based on results from test use in real operational environments and negotiations with channel partners: a grocery retailer, a postal company and a public library. The overall project executes this plan by developing the required additional technology and channel partner supported business models, allowing for accelerated roll-out across the European markets.
Coreorient Oy (founded 2011) experts are from Nokia and have 15\ years of experience in challenging R&D projects, including 16 million downloaded mobile applications and key functionality standardized for mobile devices.";71429;50000;H2020-SMEINST-1-2014;SME-1;COREORIENT OY;FI;;; 194710;651145;CAREMiBRAIN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;A new brain-dedicated Positron Emission Tomography (PET) system to identify ?-amyloid biomarker for the early diagnosis of Alzheimers disease and other causes of cognitive decline;1/10/2014;31/03/2015;;"ONCOVISION is a Spanish SME specialised in design, development, production and commercialisation of organ-dedicated PET systems. Our company submits the present innovation project with the overall objectives of marketing an innovative brain-dedicated PET system to early diagnosis of Alzheimers disease (AD) based on the detection of ?-amyloid biomarker in the brain using two 18F-labelled tracers recently approved by FDA and EMEA for their clinical use and a validation of the clinical performance of this new diagnostic device.
This new brain-dedicated PET system, targeted to Mental Disorder Units and Nuclear Medicine Units of hospitals in Europe, USA and Japan; is unique in the market and offers several advantages compared to the whole-body PET systems such as higher resolution, three times higher sensibility, a competitive price (up to three times lower), needs smaller hospital facilities, lower radiotracer dose to the patient that leads to a lesser cost to the healthcare system. Due to this improved characteristics, the new brain-dedicated PET system will help to allow an early detection of Alzheimers disease and other causes of cognitive decline and to use this business opportunity to ensure profitability and growth of ONCOVISION.
During Phase 1, a technical/economic feasibility study is envisaged to verify the viability of the product and its clinical validation. In Phase 2, the validation of clinical performance of the product will be carried out, to enable commercialisation in Phase 3.";71429;50000;H2020-SMEINST-1-2014;SME-1;GENERAL EQUIPMENT FOR MEDICAL IMAGING SA;ES;;; 194877;653618;DOGANA;SIGNED;H2020-EU.3.7.;DS-06-2014;H2020;aDvanced sOcial enGineering And vulNerability Assesment Framework;1/09/2015;31/08/2018;;"'The advent of Social Networks has made both companies and public bodies tremendously exposed to the so-called Social Engineering 2.0, and thus prone to targeted cyber-attacks. Unfortunately, there is currently no solution available on the market that allows neither the comprehensive assessment of Social Vulnerabilities nor the management and reduction of the associated risk.
DOGANA aims to fill this gap by developing a framework that delivers 'aDvanced sOcial enGineering And vulNerability Assessment'. The underlying concept of DOGANA is that Social Vulnerabilities Assessments (SVAs), when regularly performed with the help of an efficient framework, help deploy effective mitigation strategies and lead to reducing the risk created by modern Social Engineering 2.0 attack techniques. Two relevant features of the proposed framework are: i) the presence of the 'awareness' component within the framework as the cornerstone of the mitigation activities; ii) the legal compliance by design of the whole framework, that will be ensured by a partner and a work package explicitly devoted to this task. Moreover, the outcomes of the project are also expected to provide a solid basis to revise the insurance models for cyber-attacks related risks, thanks to the involvement of 2 strong DOGANA partners in this area of activity.
The project will be implemented by a consortium of 18 partners, from 11 different countries, including users, technology providers of whom 3 are major world-wide cyber-security solutions market leaders as well as legal and psychological expertise. An extensive field trial plan enables the testing of the DOGANA platform with six users (4 partners and 2 supporting users) operating in the critical areas of energy, finance, transport, utilities, and public authorities. DOGANA has also created a unique consortium with a world-wide scope.'";5822250,18;4599806,38;H2020-DS-2014-1;IA;ENGINEERING INTERNATIONAL BELGIUM SA;BE;"THALES COMMUNICATIONS & SECURITY SAS;CEFRIEL - SOCIETA CONSORTILE A RESPONSABILITA LIMITATA;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;MINISTRY OF NATIONAL DEFENCE, GREECE;THALES SERVICES SAS;DANSK BRAND- OG SIKRINGSTEKNISK INSTITUT FORENING;ELTA SYSTEMS LTD;GABINETE NACIONAL DE SEGURANCA;PROPRS Ltd.;HEWLETT PACKARD ITALIANA SRL;""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS"""""";SCUOLA UNIVERSITARIA PROFESSIONALE DELLA SVIZZERA ITALIANA (SUPSI);KATHOLIEKE UNIVERSITEIT LEUVEN;REGIA AUTONOMA DE TRANSPORT BUCURESTI;INOV INESC INOVACAO - INSTITUTO DE NOVAS TECNOLOGIAS;VISIONWARE-SISTEMAS DE INFORMACAO SA";"FR;IT;AT;EL;DK;IL;PT;UK;CH;BE;RO"; 195048;655073;ClumpLab;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;A clumped isotope laboratory for the Netherlands;1/04/2015;31/03/2017;;Analysis of the geologic record shows that Earths climate changed often, suddenly, and jumped swiftly, sometimes into extreme states, many times in its history. What is the exact nature of these climate changes? What can we learn from past changes about modern climate change? Such questions are investigated in the field of paleoclimatology. The backbone of paleoclimatology is the reconstruction and accurate quantification of key climate parameters in the past. In this context, the goal of ClumpLab is to better constrain past temperatures through the application of a new and powerful paleo-thermometer: clumped isotopes in carbonates. Currently, Europe as a whole is underrepresented in the clumped isotope research community. ClumpLab will bring the first clumped isotope facility in in the Netherlands. The method will be established at the Utrecht University, in one of the worlds best labs in the field of paleoclimate research. State of the art techniques and latest developments in the field will be implemented to refine the clumped isotope method in order to reduce necessary sample volumes and improve accuracy. The technique will then be applied on climate archives to produce novel temperature records for the Early Eocene greenhouse climate period. The results will help to improve our understanding of the climates sensitivity to greenhouse gas forcing.;177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-RI;UNIVERSITEIT UTRECHT;NL;;; 194766;652124;HEATBOOST;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Sorption Heat-pump Component Boosting Energy-efficiency in Gas-fired Boilers;1/10/2014;31/03/2015;;"Swedish award-winning cleantech company and leading supplier of sorption heat-pump components ClimateWell has recently made a technology breakthrough: A new, salt-liquid working couple that both raises the energy efficiency in gas-fired boilers and increases the temperature lift, making it possible to heat pump outside ambient air (as its renewable energy source) down to -20C. This enables retrofitting in houses with old, high temperature radiators, while achieving a Seasonal COP (SCOP) of over 130%. The solution can easily be combined with solar thermal collectors to achieve a SCOP of up to 170%.

Working already with major OEMs like GE and Alfa Laval in other applications, ClimateWell is targeting the European gas boiler OEMs such as Vaillant, BDR and Ariston to develop a Gas Heat Pump (GHP) product in which ClimateWells HeatBoost component is integrated.

It potentially saves more than 33% of the natural gas consumption (500 EUR per year) for a typical European household using a condensing gas boiler today. The cost premium can be paid off in less than 4 years, making it an attractive investment for the end-user.

While the target market for domestic space heating in Europe is huge with an installed base of 90 million boilers and over 8 million sold every year, the potential environmental impact is even bigger with a total reduction of CO2 footprint of 61.5 million tonnes/year.

In this 6-month Feasibility Study, ClimateWell will verify the technical and commercial feasibility of integrating ClimateWells new sorption component into a gas boiler system. The goal is to establish collaboration with leading European boiler manufacturers for the continued development of a GHP product and apply for funding of a Phase 2 project.
A successful outcome of the project means that once the GHP product has been commercialised in 3-5 years, ClimateWells potential revenue for providing some 2 million HeatBoost components per year to boiler manufacturers is 1 billion EUR.";71429;50000;H2020-SMEINST-1-2014;SME-1;CLIMATEWELL AB;SE;;; 194844;653285;METACLOAK;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Broadband cloaking and shielding of elastic waves in solids.;1/11/2015;31/10/2017;;"In this project we aim to develop the theory to underpin the optimal design of metamaterial devices. We will test the theory by building a metamaterial cloak which surpasses current models in its combination of elastic wave protection and cloaking capacities at frequency band much larger (~1 kHz).
The design of the cloak is based on a novel metamaterial that I have co-developed, consisting of a cluster of closely spaced sub-wavelength resonators fixed to a thin plate where flexural waves propagate.
The effective properties of this cloak are generated by local resonance effects and they include, besides large band gaps, negative diffraction (refraction) index, sub-wavelength energy focusing and broad scalability in the sound and infrasound frequency range. Contrary to other studies, it does not require an unrealistic composite material to be realised, or a periodic arrangement of resonant elements and hence it should have real practical impact. Two innovative applications concerning control of mechanical vibrations, and seismology are proposed.
To refine the modelling, detailed numerical simulations and development of optimisation schemes are required: this will benefit enormously from interaction with several groupings at Imperial College (in Physics, Mathematics and Mechanical Engineering), highly active in elastic waves and metamaterials, that have very relevant expertise.
3D numerical simulations giving quantitative analysis of the cloak properties and performance will guide the construction of laboratory models for experimental validation. The distribution and the structure of the resonators (vertical beams with nominal section much smaller than the wavelength) are the main parameters governing the performances of the cloak. The optimisation strategies that will be implemented will fine tune the cloak within a given frequency band and/or simplify the cloak design maintaining the same performance level.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;;; 194792;652506;SEA-MORE-YIELD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;Sea-More-Yield: A Blue Biotechnology Solution for the Reduction of Pod Shatter in Bio-Oil Producing Crops;1/11/2014;30/04/2015;;"The objective of the Sea-More-Yield proposal is to commercialise a disruptive blue biotechnology solution to address a bio-oil crop productivity challenge. Three years of independant trials have consistently demonstrated a 20% increase in yield over the current market leading product. Sea-More-Yield powered by Plant Signal Induction (PSI) is a novel patent pending blue biotech innovation to reduce pod shatter in Oilseed Rape (OSR) delivering 5.5bn at the farm gate if implemented across the EU-27. End result, more food and energy security, a theme underscored by Horizon 2020.Sea-More-Yield represents an excellent opportunity for the H2020 SME instrument as it will launch the participating SME Brandon Products into new markets, promote growth, and create high returns of investment. Sea-More-Yield is aligned with the call topic supporting SMEs efforts for the development - deployment and market replication of innovative biotechnology solutions for blue growth. Sea-More-Yield is a perfect example of such an opportunity. The basis of the Sea-More-Yield technology is the seaweed bioresource used in biostimulant manufacture, which is a complex and unique resource whose chemical, biochemical and biological properties provides major undiscovered potential. The main beneficiaries of the development of Sea-More-Yield will be Brandon Products; Growers of OSR gain from increased net margins, increased yield, increased quality premiums; Oil processors will have a larger quantity of high quality oil; Product distributors will have a disruptive technology with a proven mode of action; Consumers will benefit from a predictable harvest = predictable production costs = more stable pricing; The environment less agrochemicals, fertiliser more biofuel and leading to more sustainable biofuel production.";71429;50000;H2020-SMEINST-1-2014;SME-1;BRANDON PRODUCTS LTD;IE;;; 195007;654862;WITHDRAWAL AFTERMATH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Aftermath of a Drug Withdrawal: Modeling Spillover Effects Across Countries and Across Categories;1/09/2015;31/08/2017;;"The pharmaceutical market is one of the most important industries in the global economy. Projections are that spending on medicines will grow to 1.2 trillion US$ in 2016. Marketing has an important impact in this pharmaceutical industry, but has a particularly negative image. The growing pharmaceutical market increases the pressure for the regulators to approve new medicines and for firms the pressure to market their drugs to stay ahead of the competition. These forces have contributed to the fact that over the past decade many drugs were approved too early, and the number of withdrawn drugs has doubled. A drug withdrawal is when a drug is taken off the market, because it is considered to be harmful typically due to unexpected adverse effects (including deaths). Since the pharmaceutical market directly concerns population health, drug withdrawals can have disastrous consequences.
While there has been some research done into the aftermath of a withdrawal from the perspective of the focal drug, very little research has been done on the spillover effects. This project is the first to explicitly focus on spillover effects in the aftermath of drug withdrawals. There are two types of spillover effects to consider (i) across drugs (Do doctors start prescribing the competing drug, or has the withdrawal a negative spillover effect?), and (ii) across countries (If a country lags in withdrawing a drug, does the withdrawal in leading countries spill over?).
Advanced econometric techniques will be used to model the dynamics before and after withdrawals, including spillover effects and the dynamics between sales and marketing. Results of this project will not only benefit managers of pharmaceutical firms, but is also important from an economic (i.e. given the size of pharmaceutical market) and societal (i.e. the high profile nature of withdrawals and the role of government agencies) perspective.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ERASMUS UNIVERSITEIT ROTTERDAM;NL;;; 194780;652497;easierNGS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;CERTIFIED PACKS FOR EASIER NEXT-GENERATION SEQUENCING CLINICAL DIAGNOSTICS;1/10/2014;28/02/2015;;Next-generation sequencing (NGS) has revolutionized genomic research by drastically decreasing the cost of sequencing and increasing the throughput of generated data, but still has not been able to reach its implementation in clinical diagnostic laboratories where there is a huge potential market application for it. The current market gold-standard in clinical diagnostic (i.e. Sanger-based sequencing) is outdated, much less efficient and more expensive than NGS, but no current market solutions have yet been able to properly address the complexity involved in transferring and validating gold-standard procedures to NGS platforms in clinical environment. In fact, current competing solutions are disruptive, complex, non-efficient and non-validated to address the challenges of transferring NGS to clinics. The easierNGS business concept aims to create and offer an innovative package of services and products which combined will allow a fast, cost-effective, streamlined and certified full sample-to-result solution to clinical laboratories that wish to seize the tremendous benefits of the new NGS era. Towards this objective, a feasibility assessment of the easierNGS business concept will be conducted to better determine its technical, economic and legal viability, as well as plan its most appropriate operational and scheduling strategy. Three case studies (i.e. NGS panels for pharmacogenomics, neonatal screening and infertility risk factors) will be used to generate a proof-of-concept of the easierNGS and help define the technical aspects and guidelines for future easierNGS packages and support a conscientious Go/No go decision towards a real market assessment.;71429;50000;H2020-SMEINST-1-2014;SME-1;STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA;PT;;; 195033;655020;DTI4micro;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantitative characterization of cardiac tissue microstructure from Diffusion Tensor Imaging;1/09/2015;31/08/2017;;"Cardiac Ventricular Remodelling (VR), i.e. the alteration of tissue microstructure that is a hallmark of several cardiac diseases, can have profound effects on cardiac function. A novel imaging technique, Diffusion Tensor Imaging (DTI) offers the potential to quantify VR in vivo and could thus have a significant impact on the assessment and treatment of cardiac disease. This project proposes the development of advanced analytical tools to evaluate its usability in the quantitative characterization of cardiac microstructure. The tools developed will aim at a) providing a mathematical description of normality in cardiac microstructure; and b) analysing local variation as an alternative descriptor for remodelling. A combination of preclinical and clinical validation will be performed, with histological slices used as ground truth for the identification of microstructural features. Emphasis will be placed on the development and application of a rigorous mathematical framework for the processing of tensor fields, including the quantification of local differences between tensors and the construction of statistical models for the quantification of pathology.
The project joins an early researcher with extensive expertise in the statistical analysis of manifold-value data and its uses in medical imaging with an internationally recognized group in the analysis of cardiac microstructure and its links to electromechanical function. The host group has a network of collaborators including all relevant areas, from MRI physics to cardiac physiology. The program also includes the provision of further training opportunities for the applicant in different aspects from student supervision to preparation of research proposals, representing a unique opportunity for his development as an independent researcher.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194862;653413;INNOVATIONOPTIONS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Valuing Innovation Options and Policy Flexibility Under Uncertainty;1/08/2016;31/07/2019;;"This proposal consists of a two-year outgoing phase (1.5 years at MIT and 6-month secondment at LUISS U. in Italy) and one-year re-integration phase at Kings College London. Following advanced innovation training, it aims to develop new ideas and frameworks based on real options theory to appraise innovation options and policy flexibility. Besides training/development and dissemination, the proposal will examine two research themes:
(1) (First-year at MIT) Analyse flexibility in innovation and public policy under uncertainty. Examine flexible and modular design for robust corporate innovation and public policies to enable dealing proactively with policy risk. Analyse the strategic choice of when to pursue aggressive or exclusionary innovation strategies or cooperate in innovation, depending on market demand, volatility and comparative advantages;
(2) (Second-year at MIT and LUISS) (a) Theoretical analysis of how to design optimal and fair licensing terms given who controls development and other options and (b) empirical investigation (secondment at LUISS) of multi-stage R&D and IP licensing deals (viewed as compound real options), applied to a proprietary biotech/pharma licensing deals database. This is of interest to European policymakers and in line with Kings and MITs innovation- and policy-oriented strategy connecting research to business and society.
During re-integration (Third-year at Kings), an international conference, a public workshop and other outreach and dissemination activities will transfer the knowledge, experiences and insights to the European context.";269857,8;269857,8;H2020-MSCA-IF-2014;MSCA-IF-GF;KING'S COLLEGE LONDON;UK;;; 195018;654923;StrategicVillages;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Violent settlements: strategic villages and clandestine burial sites in Latin America;1/02/2016;31/01/2019;;"In contemporary warfare the power to destroy cities exists alongside with the power to built urban places ex nihilo. In the 70s and 80s, various Latin American States forcedly displaced people to villages created as an instrument of counterinsurgency; at the same time massacres and forced disappearances occurred in these regions. How does the simultaneous creation of strategic villages and clandestine burial sites affect the ways of inhabiting and imagining space in the aftermath of political violence? My study aims at analysing for the first time the connexion between mass violence and the forced creation of built environment. Based on qualitative fieldwork undertaken in Tucumn (Argentina) and Ayacucho (Peru) and framed within social anthropology, sociology and human geography, this research will produce a seminal in-depth study of the daily life among the strategic villages in Latin America, by analysing the experience of subjects that were forced to inhabit there.";201024;201024;H2020-MSCA-IF-2014;MSCA-IF-GF;ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES;FR;;; 194776;652303;PoC-Cycle;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Innovative Molecular Diagnostics point-of-care device for MRSA;1/09/2014;30/11/2014;;"FRIZ has developed PoC-Cycle platform- an innovative diagnostics device introducing efficient multiplex nucleic acid testing to the point-of-care. It provides a combination of accuracy and sensitivity, multiplexing, and optimized workflow from sample collection to diagnosis. Current diagnostics platforms are technically limited: On one side only few sequence signatures can be checked, on the other side, the analysis of these signatures are mostly considered in one sequence area only due to the high complexity in developing Multiplex-PCR, as well as missing process-robustness for routine administration. FRIZ implemented a multiplex analysis in disposable microfluidic cartridge format with integrated semiconductor based on microarrays for the rapid and sensitive detection of a broad range and number of biomarkers.
Key market is the screening of MRSA, a pathogen with wide spread and growing negative impact to European patients and health care systems. Experts forecast the number of deaths will increase from 6,000 to approx. 17,000 in 2015. Main users of the device are hospitals as they require simple and safe handling as well as fast and reliable results. European market potential can be estimated with 900,000 tests per year resulting in a yearly turnover of almost two million . The new diagnostic device will significantly reduce the number of infections. Moreover, it provides future business opportunities due to its general approach for diagnose further pathogens e.g. HPV or tuberculosis.
Within the project, FRIZ aims to identify end-users for validation, discuss the handling and identify possible variations to enhance the usability and acceptance of the new system in phase 2. To find an appropriate partner for validation is also part of this feasibility study. In addition, FRIZ prepares a revised version of a freedom-to-operate analysis. A multicentric validation study is planned as well as interviewing end-users and built up a pilot production in phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;FRIZ BIOCHEM GESELLSCHAFT FUR BIOANALYTIK MBH;DE;;; 194902;653851;JOSPEL;SIGNED;H2020-EU.3.4.;GV-2-2014;H2020;Low energy passenger comfort systems based on the joule and peltier effects.;1/05/2015;31/10/2018;http://www.jospel-project.eu;The aim of JOSPEL project is the development of a novel energy efficient climate system for the optimization of interior temperature control management in electrical vehicles through an integrated approach that combines the application of the thermoelectric Joule and Peltier effect, the development of an efficient insulation of the vehicle interior, the energy recovery from heat zones, battery life increase duration enhancement as a side effect of thermal management, battery consumption reduction by Peltier cooling integration, innovative automated and eco-driving strategies and the electronic control of power flows. Main objective is the reduction of at least 50% of energy used for passenger comfort (<1,250 W) and at least 30% for component cooling in extreme conditions with reference to electric vehicles currently on the market.;6668288;6668288;H2020-GV-2014;RIA;AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS;ES;"SIMOLDES PLASTICOS SA;FUNDACION PARA LA PROMOCION DE LA INNOVACION, INVESTIGACION Y DESARROLLO TECNOLOGICO EN LA INDUSTRIA DE AUTOMOCION DE GALICIA;ALKE SRL;CLEANCARB SARL;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;EUROPEAN THERMODYNAMICS LIMITED;ARKEMA FRANCE;AMV DESIGN SRL;DOK-ING DRUSTVO S OGRANICENOM ODGOVORNOSCU ZA INZENJERING I UNUTARNJU I VANJSKU TRGOVINU;DURPLASTICS SA;ATOS SPAIN SA;CIDETE INGENIEROS SL;INSERO AS";"PT;ES;IT;LU;DE;UK;FR;HR;DK"; 194704;651065;MARKinPATH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of a bioMARKer for use in INtestinal PATHologies;1/10/2014;28/02/2015;;"MARKinPATH global innovation project aims at undertake the clinical validation of Xylose, after ingestion of Gaxilose, as a Biomarker of intestinal diseases. Currently, the measurement of Xylose after ingestion of Gaxilose is used to evaluate hypolactasia in adults. MARKinPATH is focused to improve the hypolactasia diagnosis; broaden the pathologies to monitor and to extend his use to paediatrics population.

MARKinPATH will meet the demand of the EU on and innovation in healthcare, by enhancing diagnosis and management of intestinal pathologies. The resulting solution will also contribute to cost-effective and efficient health expenditure.
Xylose-based, after ingestion of Gaxilose, biomarker improves technical features such as specificity and sensitivity with respect to the other tests available in regular clinical practice. Furthermore, alternative methods such as Hydrogen breath test (HBT) and the Lactose tolerance test (LTT) are invasive and have adverse effects that can be very annoying for the patient.

Venter Pharma is a highly innovative SME with more than 11 years focused on advanced research, development and commercialization of clinical solutions in this field. Venter Pharma has a relevant Intellectual Capital and an extensive background in these technologies.

MARKinPATH would suppose a massive-but-necessary growth and the consolidation of Venter Pharma in the pharmaceutical market.";71429;50000;H2020-SMEINST-1-2014;SME-1;VENTER PHARMA S.L.;ES;;; 194804;652644;SeaChange;SIGNED;H2020-EU.3.2.;BG-13-2014;H2020;Sea Change;1/03/2015;28/02/2018;;"The overarching goals of the Sea Change project are to bring about a fundamental Sea Change in the way European citizens view their relationship with the sea, by empowering them as Ocean Literate citizens - to take direct and sustainable action towards healthy seas and ocean, healthy communities and ultimately - a healthy planet.

Key objectives of Sea Change are to:
Compile an in-depth review of the links between Seas and Ocean and Human health based on latest research knowledge outputs
Build upon the latest social research on citizen and stakeholder attitudes, perceptions and values to help design and implement successful mobilisation activities focused on education, community, governance actors and directly targeted at citizens. marine education
Build upon significant work to date, adopting best practice and embedding Ocean Literacy across established strategic initiatives and networks in order to help maximise impact and ensure sustainability
Ensure that efforts to sustain an Ocean Literate society in Europe continue beyond the life of Sea Change through codes of good practice, public campaigns and other ongoing community activities.
Ensure that all activities of Sea Change are carefully monitored and evaluated to ensure maximum sustainability, effectiveness and efficiency
Ensure Knowledge exchange with transatlantic partners to bring about a global approach to protecting the planets shared seas and ocean.
The objectives will be achieved by a closely interlinked programme. Sea Change includes a mobilisation phase engaging with citizens, formal education and policy actors. Crucially the legacy of Sea Change, including continuing knowledge sharing with North America, are embedded within the project.";3494876;3494876;H2020-BG-2014-1;CSA;MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM;UK;"ASSOCIACIO SUBMON: DIVULGACIO, ESTUDI I CONSERVACIO DE L'ENTORN NATURAL;AquaTT UETP Ltd;THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS;COEXPLORATION LIMITED;RESEAU OCEAN MONDIAL AISBL;CIIMAR - Centro Interdisciplinar de Investigao Marinha e Ambiental;VLAAMS INSTITUUT VOOR DE ZEE VZW;EUROGEO VZW;HELLENIC CENTRE FOR MARINE RESEARCH;CIENCIA VIVA-AGENCIA NACIONAL PARA A CULTURA CIENTIFICA E TECNOLOGICA;Goeteborgs Universitet;FONDATION EUROPEENNE DE LA SCIENCE;NATIONAL UNIVERSITY OF IRELAND, GALWAY;ASSOCIATION EUROPEENNE DES EXPOSITIONS SCIENTIFIQUES TECHNIQUES ET INDUSTRIELLES;DANMARKS TEKNISKE UNIVERSITET;UNITED NATIONS EDUCATIONAL, SCIENTIFIC AND CULTURAL ORGANIZATION -UNESCO";"ES;IE;UK;BE;PT;EL;SE;FR;DK"; 194912;653957;DEVOLEMPA;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The developmental and evolutionary basis of human intersubjectivity;1/10/2015;30/09/2017;;This research aims to unravel the ontogenetic and phylogenetic roots of the unique human intersubjectivity. Empathy forms the basis of intersubjectivity. In the first part of the research, we address empathy development in young, 6-16-month-old infants who engage in interactive, intentional communication but do not yet cognitively represent others mental states. They may, however, attend to and show concern of others emotional states, indicating dispositional empathic orientation. This tendency is tested in a peer context, involving emotions of positive and negative valence. In addition, we assess the infants early communicative and prosocial behaviours in the emotionally charged situation. This will reveal the early developmental phases of the fundamental base for intersubjectivity. In the second part of the research, the evolution intersubjectivity is tested by assessing empathy in non-human primates. According to the recent cooperative breeding hypothesis, humans evolved as cooperative breeders, which increased sensitivity and motivation to attend to and show concern of others emotional states. The hypothesis is tested by assessing rudimentary empathy in common marmosets, a distantly related cooperatively breeding monkey. To allow full comparability, we will use identical methods in the infant and the marmoset studies. The study incorporates theoretical backgrounds and methods from several disciplines, i.e., comparative cognition, animal behaviour, developmental psychology, evolutionary anthropology, and sociological interaction research. The multidisciplinary approach yields understanding of the emotional and cognitive foundation of intersubjective interactions no single discipline can achieve alone. Moreover, the study yields fruitful prospects for future research lines in the respective disciplines and their synthesis.;179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 194751;651800;CryoPlankton;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";BG-12-2014-1;H2020;A replacement of the sub-optimal live feeds used at hatcheries today with a new cryopreserved live diet for the improved and efficient production of juveniles in marine aquaculture;1/10/2014;31/03/2015;;"The most important innovation in marine fish aquaculture is the improvement of survival rate and development during the larval stage of the fish. Reasons are that the current nutritional quality of most common live food organisms (rotifers and Artemia nauplii) is inadequate leading to high mortality, deformations and sub-optimal growth during the larval phase of these fish species which limit the overall production.

This projects primary objective is to cryopreserve targeted natural zooplankton harvested from the sea, which will be revived for the use as live feed organisms in marine aquaculture. The SME Planktonic has succeeded in cryopreserving marine crustacean nauplii in relatively large scale (entities of up to 200 ml), and to revive them as free swimming organisms (revival rate up to 90%). Because fish larvae are evolutionary adapted to graze on these plankton organisms, it is believed and also documented that it is an optimal diet with respect to nutritional value and performances on the fish growth and survival.

Present cryopreservation protocols owned by Planktonic will be further optimized for large scale fish larvae cultivation of both current successful aquaculture species (sea bream and sea bass) and those with requirements of prey of high nutritive value and appropriate size in their early larval phase (e.g. bluefin tuna, long fin yellow tail and Ballan wrasse). Logistics systems for economically feasible shipping of the cryopreserved product within and outside the EU will be assessed, besides procedures for removing market barriers.

The world-wide market of Artemia nauplii and rotifers is estimated to about 450 million . Planktonic is aiming at 10% of this market, which will result in a turnover of 45 million .

Planktonic will in the proposed project perform a feasibility study with the focus of a business plan, potential partners to succeed with the commercialization and evaluate different technologies for up-scaling of the production.";71429;50000;H2020-SMEINST-1-2014;SME-1;PLANKTONIC AS;NO;;; 194698;650856;BLEticket;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Mobile ticketing system for urban transport;1/09/2014;30/11/2014;;"For over years integrated ticketing based on Smartphones has been on the agenda of EU transport policy due to his potential for intermodal transport. The future challenge of transport sector is to combine all urban transport modes (metro, bus, train) on a single ticket facilitating transfer between them and to enable pay per use approach offering novel pricing model to passengers.


Until now, the only two systems enabling users to pay with Smartphones are based on Quick Response (QR) code and Near Field Communications (NFC) technology. However, none of them can be adopted as mobile eticketing system applicable on a wider scale in Europe; QR code pose serious security risks and NFC suffer with lack of interoperability, limited versatility and is not supported by Apple (iOS), the landmark for mobile technology trends.

The overall objective of the project is to provide novel eticketing based on Bluetooth Low Energy (BLE) technology. This new approach represents a real break-through in eticketing systems due to their low cost, low consumption, ultra rapid connection, improved coverage and interoperability of operators and platforms. BLE is already incorporated by Apple and most important brands featuring Android are also adopting it.

The proposed system offer huge number of benefits to all stakeholders involved; Bus transport operators will obtain better transport statistics, reduced small-cash transaction, and reduced fare-processing time and better passenger throughput. Passengers will have more flexible mode choice and easier interchange, enhanced ease of use and more flexible choice and easier interchange. Authorities will reduce environment impact, increase in transport usage and reduce traffic congestions.

The objective of this phase 1 is to complete a feasibility study to find out the workability and profitability of the business venture. If the result of the feasibility study is positive, we will write the Business Plan and we will apply to phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALESTIS CONSULTING SL;ES;;; 194691;650745;BeadCAP-DNA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;BeadCAP-DNA: 30-minute on-site DNA test kit;1/10/2014;31/01/2015;;"BeadCAP-DNA aims to create a world-first 30-minute on-site DNA test kit, for food provenance, thereby eliminating the 2 to 5 day wait for DNA results from a central Lab. This is achieved by a novel merging of molecular biology and semiconductor capacitive sensing in a single-use microfluidic disposable DNA test kit. No such solution currently exists. Our prototype has no molecular amplification, i.e. no risk of on-site cross-contamination. It has 3-orders of magnitude response, enabling qualitative and quantitative DNA detection. The first product version is defined with end-user customers as 8-multiplex, aimed at GMO detection & 8-food-species testing to 0.1% limits. 3 patents are pending.

BeadCAP kits will address the huge un-met need for fast on-site DNA food diagnostics. Consumer trust will be significantly increased by on-the-spot DNA-ID-tests of food content and GMOs. BeadCAP will help food processors and retailers eliminate costly quarantines and food recalls, food wastage, risk of reputational damage and loss of sales (e.g. horse-burger crisis 2013). BeadCAP will also accelerate uptake of EURL regulations on DNA-testing of food and shell-fish, thus increasing food safety, and reducing food fraud, mislabelling, and adverse health issues.

The AltraTech trans-disciplinary team has 30 previous patents and >100 years experience in semiconductors, molecular biology, microfluidics, venture-capital fundraising, and commercialization success. Our ambition is to scale up BeadCAP-DNA to 100M revenue in high-growth niches of the 4B food-test market, and become a full product solutions supplier and world leader in portable on-site point-of-use DNA diagnostics.

We've raised 900,000 seed funds to date. In this SME-Inst-Phase-1 feas.study we aim to do DNA trials & investigate technical and commercialization risk reduction. We target Phase-1 final report on 30/11/2014, and aim to submit business-plan to 17/12/2014 SME-Inst-Phase-2 call, target up to 2M.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALTRATECH LIMITED;IE;;; 194736;651574;OpticTrainDetection;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Optical and Acousto-optic Sensor Technology for Railway-Applications;1/10/2014;31/03/2015;;"Frauscher Sensortechnik GmbH is technology and market leader in the area of inductive sensor technology solutions (40% global market share). For its further development we are continuously innvoating our product portfolio.
The presented project aims at the development and commercialisation of optic sensor technology (Fibre Bragg Grating, Distributed Accoustic Sensors) in the railway application. The new technology should complement state-of-the-art inductive sensor technology which show some limitations (electromagnetic interference with magnetic rail brakes, high costs due to expensive cable connections etc.).
Within the proposed feasibility study a technical, economical and regulatory assessement will be conducted in order to establisch a business plan. It will be the basis for an innovation project (phase 2 of the SME-isntrument) during 2015/2016.
The commercial exploitation of the development will be ensured by a worldwide presence of Frauscher Sensortechnik GmbH (Headquarter in Austria) in the form of subsidiaries (Poland, India, Brasil, CIS, UK). With the new technology a continuous growth of the company will be possible. A total market volume of 14 billion EUR in the area of signalling and safety infrastructure on railways is an attractive argument to invest into this innovation project. The innovation will allow FRAUSCHER to grow further and faster in the upcoming years.";71429;50000;H2020-SMEINST-1-2014;SME-1;FRAUSCHER SENSORTECHNIK GMBH;AT;;; 194761;651970;POLYSOLAR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;A light weight, recyclable, tracking support system, for solar photovoltaic modules based on inflatable polymer membranes;1/10/2014;31/03/2015;;"POLYSOLAR Short Summary

Established in 2009 in Berlin, Germany, Solardynamik provides renewable energy consulting services, conducts researches and develops innovative solutions for the solar PV sector. We have developed, patented and demonstrated an innovative, light-weight, tracking support system for solar PV modules based on a recyclable, inflatable polymer membrane. Support systems are used to hold solar modules in place and may be either fixed-tilt or tracking types. Tracking types orient PV modules toward the sun to improve efficiency.

The main advantages of the system are: Up to 68% less cost than SoA and 70% lighter; Up to 30% more annual energy production than fixed-axis solutions; Compact and light weight - cost effective transport and installation, can be used on wider range of light weight structures; Can fully deflate under wind loads suitable for use in hurricane prone regions; Up to 44% less CO2 emission in manufacture; Transparent body provides architectual advantages, allows light penetration when mounted as a lattice or when used with semi-transparent solar cells, lighting applications; 100% recyclable, and future polymers from renewable sources; Dual use of land with exisiting agricultual or other activity (eg carport).

We expect to enter the market in 2017, after securing external funding of around 2.2 million. and predict a total net income in the range of 4.29 million over a 5-year period. Additionally we create 38 new positions in our company over that period.

In Phase 1 our objectives are: 1.) to analyse the results of the prototype demonstration to identify potential improvements; 2.) to identify potential manufacturers of the system components; 3.) to further assess and protect our intellectual property; 4.) to perform a detailed study of the target markets; 5.) to identify and assess potential distribution partners in Europe and abroad.";71429;50000;H2020-SMEINST-1-2014;SME-1;SOLARDYNAMIK GMBH;DE;;; 194829;653019;CEREBSENSING;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Cerebellar Distributed Plasticity Towards Active Sensing and Motor Control;1/11/2015;31/10/2017;;"The ability to perceive and understand the state of the surrounding environment and the own state is critical for next generation robotic systems. To that aim, the human brain is still far beyond current artificial systems performance due to its capability of processing huge amounts of heterogeneous sensorial data. Interestingly, the cerebellum has been shown to play a crucial role in the generation of dexterous movements as evidenced from cerebellar ataxic patients. Behavioural studies suggest that the cerebellum actively improves sensorial discrimination and proprioception thanks to the prediction of the sensorial consequences of actions. In the last decade, several forms of long-term synaptic plasticity have been observed within the cerebellum, suggesting that distributed plasticity could support the predictive action. However the way in which those mechanisms cooperate in order to improve the function of the whole cerebellar network is not completely understood. In this project, the candidate will develop a novel theory of sensorial information representation and processing based on the cerebellar architecture. The proposed model will make use of long-term synaptic plasticity mechanisms distributed along connections existing in the cerebellar input layer (granular layer) to iteratively create sparse representations of the information, allowing fast and effective learning in successive layers. The predictions extracted from this model will be useful to design new experimental protocols to unveil the cerebellar role in acting and sensing.
By providing multiple relevant contributions across the spectrum of the H2020 objectives in terms of its potential to advance robotic manufacturing, brain processing understanding, and novel computing paradigms, this project will enable the candidate to enhance his position at the forefront of advances in this field.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD DE GRANADA;ES;;; 194910;653943;Moments;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Moment inequalities in matrix algebras;1/09/2015;31/08/2017;;In the last few years the non-commutative moment inequalities have received a considerable attention in matrix analysis and operator theory. This phenomenon originates on the one hand in studies on the extreme properties of the standard deviation in quantum information theory, and on the other hand, in the recent concept and developments of quantum metric spaces. This research project will investigate trace inequalities in matrix algebras. Particular attention will be paid on moment inequalities for matrices with a special emphasis on their counterparts in operator algebras. It will focus on determining the best upper and lower bounds for higher order central moments in matrix algebras. This will be followed by a study of the relatively new concept of Leibniz seminorms in Banach algebras. The project will pursue a research on the strong Leibniz property of central moments in non-commutative probability spaces as well as in the classical ones in order to solve the recent question whether every centered moment has the strong Leibniz property or not.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE;UK;;; 194814;652782;FOSICAV;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Families of Subvarieties in Complex Algebraic Varieties;1/09/2015;31/08/2017;;"In relation with the study of both moduli and enumerative problems in complex algebraic geometry, we propose the geometric study of various families of subvarieties of certain complex algebraic varieties of small dimension, and mainly of families of (possibly singular) curves. The Severi varieties are a typical example: they parametrize curves of given degree and geometric genus in the projective plane; the general such curve has a prescribed number of ordinary double points and no further singularity.

Apart from exploring their dimensions, smoothness, and irreducibility properties, we have in mind to determine their Hilbert polynomials (which among other things encode their degrees, the latter being important enumerative invariants).

A central feature of our project is to conduct this analysis by degeneration: to study families of subvarieties in a given variety X, we let X degenerate and look at what happens in the limit. For instance, to study curves on a general K3 surface, we can let it degenerate to a union of projective planes, the dual graph of which is a triangulation of the real 2-sphere.

We shall consider the following kind of families of subvarieties: families of curves with prescribed invariants and singularities in surfaces (with special attention to the two cases of the projective plane, and of K3 surfaces), families of hyperplane sections with prescribed singularities of hypersurfaces in projective spaces, families of curves with a given genus in Calabi-Yau threefolds, and families of surfaces in the projective 3-space containing curves with unexpected singularities.";180277,2;180277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA;IT;;; 194801;652641;EU-PolarNet;SIGNED;"H2020-EU.3.5.;H2020-EU.3.2.";BG-15-2014;H2020;Connecting Science with Society;1/03/2015;29/02/2020;;"The rapid changes occurring in the Polar Regions are significantly influencing global climate with consequences for global society. European polar research has contributed critical knowledge to identifying the processes behind these rapid changes but, in contrast to lower latitudes, datasets from the Polar Regions are still insufficient to fully understand and more effectively predict the effects of change on our climate and society. This situation can only be improved by a more holistic integrated scientific approach, a higher degree of coordination of polar research and closer cooperation with all relevant actors on an international level as requested in the Horizon 2020 work programme.
The objectives of EU-PolarNet are to establish an ongoing dialogue between policymakers, business and industry leaders, local communities and scientists to increase mutual understanding and identify new ways of working that will deliver economic and societal benefits. The results of this dialogue will be brought together in a plan for an Integrated European Research Programme that will be co-designed with all relevant stakeholders and coordinated with the activities of many other polar research nations beyond Europe, including Canada and the United States, with which consortium partners already have productive links.
This consortium brings together well-established, world-class, multi-disciplinary research institutions whose science programmes are internationally recognised for excellence. Alongside these scientific capabilities, the national programmes represented in this proposal possess a unique array of infrastructure and operational expertise to support science in both Polar Regions. The consortium is uniquely well positioned to significantly enhance Europes capabilities to undertake state of the art science and cost-efficiently operate infrastructure in the hostile polar environments.";2174503,75;2174503,25;H2020-BG-2014-1;CSA;ALFRED-WEGENER-INSTITUT HELMHOLTZ- ZENTRUM FUER POLAR- UND MEERESFORSCHUNG;DE;"POLARFORSKNINGSSEKRETARIETET;Arctic Monitoring and Assessment Programme Secretariat;GRONLANDS NATURINSTITUT;INSTITUT ROYAL DES SCIENCES NATURELLES DE BELGIQUE;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;TALLINNA TEHNIKAULIKOOL;VRIJE UNIVERSITEIT BRUSSEL;INSTITUT POLAIRE FRANCAIS PAUL EMILE VICTOR;INSTITUTO DE GEOGRAFIA E ORDENAMENTO DO TERRITORIO DA UNIVERSIDADE DELISBOA;MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD;WOC - WORLD OCEAN LIMITED;BULGARSKI ANTARKTICHESKI INSTITUT ASSOCIATION;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;Instytut Geofizyki Polskiej Akademii Nauk;CONSIGLIO NAZIONALE DELLE RICERCHE;NORGES FORSKNINGSRAD;UNIVERSITAT WIEN;OULUN YLIOPISTO;Geological Survey of Denmark and Greenland;RIJKSUNIVERSITEIT GRONINGEN;NATURAL ENVIRONMENT RESEARCH COUNCIL";"SE;NO;GL;BE;ES;EE;FR;PT;UK;BG;PL;IT;AT;FI;DK;NL"; 194847;653321;WISER;SIGNED;H2020-EU.3.7.;DS-06-2014;H2020;Wide-Impact cyber SEcurity Risk framework;1/06/2015;30/11/2017;;"WISER delivers a cyber-risk management framework able to assess, monitor and mitigate the risks in real time, in multiple industries. WISER incorporates socio-economic impact aspects, building on current state of the art methodologies and tools, and leveraging best practices from multiple industries and international initiatives (e.g: NIS). WISER aims at implementing an impressive series of 9 short experiments, in the form of Early Assessment Pilots (EAPs) to test the resilience of different risk management frameworks (taken from different industries and intended broadly) with regards to both traditional and advanced cybersecurity threats. The EAPs allow taking elements that work best in cybersecurity risk management from different frameworks, to then build and implement an advanced risk management system that will be tested & validated in 3 Full- Scale Pilots (FSPs) with different, high-impact instantiations in the financial services and insurance industry and in the energy field to demonstrate market acceptance, as well as scalability of a risk management framework for cybersecurity.
The WISER framework will ensure cyber risk management becomes an integral part to good business practice in both critical infrastructure & process owners and ICT-intensive SMEs by offering two delivery modes: a pre-packaged solution for addressing basic cyber risk management needs (i.e. SMEs), and a Risk Platform as a Service (RPaaS) mode of operation of the platform, intended for critical infrastructures or highly complex cyber systems requiring the implementation of special controls within the ICT system to be monitored. Ultimately, WISER implements on-demand service composition and ignites innovative assurance models, also from the point of view of premiums determination targeting. Significant outcomes of the project are also the RPaaS business model, the community of end-users, and the multi-industry synergy & standardization strategy.";3396455;2562596;H2020-DS-2014-1;IA;ATOS SPAIN SA;ES;"ENERVALIS;AON SPA INSURANCE & REINSURANCE BROKERS;STIFTELSEN SINTEF;DOMOTECNICA SPA;XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO;REXEL DEVELOPPEMENT SAS;AON UK LIMITED;TRUST-IT SERVICES LIMITED";"BE;IT;NO;SI;FR;UK"; 194897;653762;EMYNOS;SIGNED;H2020-EU.3.7.;DRS-19-2014;H2020;nExt generation eMergencY commuNicatiOnS;1/09/2015;28/02/2018;;Current emergency systems and 112 services are based on legacy telecommunication technologies, which cannot cope with IP-based services that European citizens use every day. Some of the related limitations are the partial media support (so far, only voice calls and SMS are accepted), the lack of integration of social media, and the use of an analog modem for providing eCall services with limited data amount. As most operators have started migrating towards broadband IP-based infrastructures, current emergency systems need also to be upgraded/adapted in order to fulfill regulatory requirements in terms of Next Generation emergency services. ?he main objective of EMYNOS project is the design and implementation of a Next Generation platform capable of accommodating rich-media emergency calls that combine voice, text, and video, thus constituting a powerful tool for coordinating communication among citizens, call centers and first responders. Additionally, issues such as call routing/redirection to the closest-available call center, retrieval of the caller location, hoax calls prevention, support for people with disabilities, and integration of social media will be addressed. EMYNOS will enable users to make emergency calls across heterogeneous devices (e.g. PCs, TV sets, mobile, AAC and haptic devices) using various mature technologies, including those making use of the Session Initiation Protocol (SIP), the IP Multimedia Subsystem (IMS), and WebRTC framework. EMYNOS will also demonstrate how the eCall concept can benefit from the IP technologies by allowing audio-video calls towards the emergency call centers and complementing location information, with photos and videos. EMYNOS involves partners with complementary expertise (telecom/satellite operator, VoIP provider, eCall testers, end users), which together form the chain for the provision of emergency services and which will deliver the EMYNOS demonstrator that will be validated in operational environment (TRL 7);4130493;4130493;H2020-DRS-2014;RIA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"NAVCERT GMBH;OSTERREICHISCHES ROTES KREUZ;TURKSAT UYDU HABERLESME VE KABLO TV ISLETME AS;MCS DATALABS;TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CRETE;Serviciul de Telecomunica?ii Speciale - UM 0572 Bucure?ti;Harpo Sp. z o. o.;HELLENIC OPEN UNIVERSITY;VOZTELECOM SISTEMAS S.L.;PUBLIC SAFETY COMMUNICATION EUROPE FORUM AISBL";"DE;AT;TR;EL;RO;PL;ES;BE"; 194674;650651;COFASTRANS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;A FAST AND ECO-EFFICIENT TRANSHIPMENT SYSTEM FOR ULTRA LARGE CONTAINERVESSELS;1/10/2014;31/03/2015;;"The aim of the project is the design of an integrated intermodal system ideally suited for fast loading/unloading of the new Ultra Large Container Vessels and the subsequent fast terminal stowage of the containers. The proposed container terminal includes two major innovative concepts: a) a small number of indented berths for accommodating the new ULCVs which are handled by new multi-trolley portal container cranes enabling fast loading and unloading from both sides of the ship and b) a multi-level container terminal with ground running lanes, elevated container flow roadways and an innovative system for placing hatch covers. The above arrangement is proposed in combination with ordinary line quays with conventional container cranes for accommodating the smaller vessels.
The business plan will include description of the new system, its equipment and operations, market analysis, logistics details, description of human resources, environmental benefits, financial risk assessment, calculation of costs and cash flows from sales of services, funding sources, NPV and IRR of the investment, payback period, effect of the new system on local economies, savings in electricity, fuel, wages, and increase in annual throughput capacity among various parties and stakeholders. Detail studies are going to be carried out in phase 2, providing results for the dimensions of the new portal cranes, their aerodynamic profile and connections and optimising container stacks and roadways around the indented berths and the use of automated systems.
The completion of the project will provide a solution to the limitations of the existing container terminals to cope with the new ULCVs and will free the design of the ULCVs from limitations imposed by the capabilities of the current loading/unloading means.
The proposed solution aims at the global container terminal market. European ports will be the main target group, although trading partners of EU in the world are also to be considered.";71429;50000;H2020-SMEINST-1-2014;SME-1;BECKETT RANKINE LIMITED;UK;;; 194680;650989;Ultramelt;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;An innovative, disruptive, advanced technology for ultrasonic flow enhancement of injection moulding that significantly reduces cooling times improves productivity;1/10/2014;31/03/2015;;"Injection moulding is a large portion of the EU thermoplastics processing industry. In 2008, its value was 55 bn, but fell to 43 bn in 2009. The industry continues to contract, struggling against low cost economies. While energy cost savings are welcome, cycle time dominates cost so reducing it is key & will increase productivity. Cycle time is dominated by cooling time, which depends on many factors including melt temp. Polymers are often heated well above the ideal melt temp. to aid injection by lowering viscosity. Similarly, very high injection speeds/pressures are used. But we show later that these methods have drawbacks. Our idea is to apply ultrasonic energy into the molten polymer just before it enters the cavity. This can achieve as much as 60% reduction in melt viscosity, enabling a significant reduction in melt temp. while still being able to fill the mould. Lower embodied heat reduces heating/cooling time & energy.

Key benefits are that melt temps. can be maintained and the lower viscosity used to enable easier filling of existing parts with lower internal stresses; melt temp. can be reduced significantly, reducing thermal degradation, energy consumption & cooling time. Or melt temp is maintained and much longer flow paths or thinner wall sections can be filled, offering a step change in design for thinner parts with even shorter cooling time. The ultimate goal of the Phase 2 project is to achieve market readiness of the Ultramelt process, with follow-on Phase 3 achieving commercialisation in the EU marketplace. This technology could enable EU moulders & extruders to increase productivity by 50%, increasing competitiveness, enabling them to regain market share and capitalise on new business opportunities.";71429;50000;H2020-SMEINST-1-2014;SME-1;THE TECHNOLOGY RESEARCH CENTRE LIMITED;UK;;; 194799;652637;BioHorizon;SIGNED;H2020-EU.3.2.;ISIB-09-2014;H2020;Cooperation between NCPs for Horizon 2020 Societal Challenge 2 on Food security, Sustainable Agriculture, Marine and Maritime Research and the Bioeconomy and the Key Enabling Technology (;1/03/2015;28/02/2019;;The overall idea of the BioHorizon proposal is to establish innovative and mutually learning pan-European platform for transnational activities of NCPs involved in the SC2 and KET-B. The aim is also to create a network of NCPs exploiting the synergies of acquired and distributed knowledge, collective development and trainings, in which all NCPs can learn from each other, thus increasing mutual understanding of different approaches and requirements in the daily work of an NCP. The network will develop novel, high quality services provided to SC2 and KET-B beneficiaries. The excellent assistance provided by BioHorizon will go beyond typical NCP services, since the established network will put an emphasis on complex and multidisciplinary aspects of Horizon 2020, including widening participation of the EU 28. The methodology applied to achieve the objectives includes: trainings, workshops addressed at NCP needs identified during the evaluation of current activities,, networking staff exchange programme, e-mentoring scheme and trans-national brokerage events. Furthermore, based on the results of the previous project, the new BioHorizon will greatly improve and enhance capacity building and networking opportunities by continuing with activities and measures proven to be successful, but also including new elements. BioHorizon will fully cover activities that include innovative and efficient training of NCPs across Europe, thus helping to simplify and increase access to H2020 calls, lowering barriers for newcomers and improving the quality of proposals submitted. Special attention will be given to networking and improved collaboration of the ICPC NCPs, supporting and increasing their integration with the European NCPs. BioHorizon aimes to generate high impact on different levels: improvement and professionalisation of NCP services, higher number and higher quality of proposals submitted through the establishment of an active network of SC2 and KET-B NCPs at European level.;2089912,5;1999631,25;H2020-ISIB-2014-1;CSA;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;PL;"THE ICELANDIC CENTRE FOR RESEARCH;FORSCHUNGSZENTRUM JULICH GMBH;TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY;AGENCE BRUXELLOISE POUR L'ENTREPRISE;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;ASSOCIATION DE COORDINATION TECHNIQUE POUR L'INDUSTRIE AGROALIMENTAIRE;CENTRUL PROIECTE INTERNATIONALE;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;VEREIN EURESEARCH;MINISTERIE VAN ECONOMISCHE ZAKEN;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;MATIMOP - THE ISRAELI CENTER FOR R&D;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"IS;DE;CZ;BE;EL;FR;MD;HR;CH;NL;TR;IL;IT;PT"; 194728;651485;LUBRICAIRLESS;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Lubrication system by oil mist;1/10/2014;28/02/2015;;"The main objective of the project is to introduce and sell an innovative technology for the lubrication of industrial machinery on the global market.
This technology consists of a new lubrication system by means of oil mist. Compared with existing systems (Venturi and Vortex), it is much more efficient (90% reduction of energy consumption while in operation), more respectful of the environment (based on an analysis of the life cycle) and may also be used in systems that require high viscosity lubrication oils, thus replacing high energy-consuming technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;GRUPO TECNICO RIVI;ES;;; 194887;653640;GuiDanCe;SIGNED;H2020-EU.3.3.;Energy;H2020;Support the coordination of cities activities via the Green Digital Charter;1/03/2015;28/02/2018;;"'The Green Digital Charter is a EUROCITIES response, initiated by Clicks and Links Ltd and the City of Manchester, as part of a Greenshift initiative. It has been realised through the work of the EUROCITIES Knowledge Society Forum (KSF) Working Group on ICT for Energy Efficiency, led by the City of Manchester. It was built on ICT-enabled sustainability initiatives like 'Smart 2020,' with Global e-sustainability initiative and the Climate Group, and 'ICT4EE' with the European Commission.

From September 2011 to May 2014, European Commission awarded the FP7-NiCE project grant to provide a platform for action based on the Green Digital Charter. Following the first five years of promoting and working with the Green Digital Charter as well as the conclusion of NiCE project, GuiDanCe will build on the outcomes of NiCE and address the identified challenges that need to be further tackled.

The aim of GuiDanCe project is to provide GuiDanCe and support cities activities towards their Green Digital charter commitments so that they eventually take ownership of the Charter.

The project will work for three main objectives:
1. Strengthen the engagement of GDC signatories to create a club of cities that work together towards their GDC commitments
2. Improve existing tools and services and their impact to GDC signatories
3. Promote GDC signatories activities in and outside the EU

The GuiDanCe project addresses the work programme topic Support the coordination of cities' activities via the Green Digital Charter and will be coordinated by EUROCITIES, a network of over 140 major European cities.'";603687,5;499750;H2020-Adhoc-2014-20;CSA;EUROCITIES ASBL;BE;;; 194786;652411;SKLCarbon;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Development of CDC production technologies for the next generation of supercapacitors, feasibility study;1/10/2014;31/03/2015;;"Skeleton Technologies is a developer and manufacturer of high performance ultracapacitors, devices which store and deliver energy much more rapidly than conventional batteries. Their specialist technology, based on in-house-manufactured carbide derived carbon (CDC) electrodes, produces 2.5 times the power to weight ratio, subsequently a 40% reduction in costs, compared to the state of the art.

The company aims to build on successful sales to niche space and motorsport markets, by up-scaling CDC production, reducing costs, allowing for more ubiquitous adoption of their products for energy-saving applications in price-sensitive markets. Initially, Skeleton will fulfil explicit demand in the automotive industry for high current, high power/weight ultracapacitors, facilitating advances in stop-start, regenerative braking and cold starting technologies. Applications have also been identified in smart grids, supporting renewable energy sources and circumventing power outages.

Skeleton also plans to market its specially treated CDC materials to manufacturers of ultracapacitors and Li-ion capacitors, and to investigate further identified uses, such as in advanced batteries, gas adsorption, water desalination and as a catalyst in fuel cells.

The Phase I feasibility study will comprise two consecutive parts: 1) completion of the planning for the up-scaled CDC production facility (to be implemented in the 24 month Phase II project), and 2) conduction of collaborative consultation with other ultracapacitor manufacturers, who will be early adopters of the CDC.

The project will address the European and global challenge of developing low carbon and efficient energy systems. CDC based ultracapacitors will facilitate advanced energy efficiency and energy recapturing systems, and will support renewable energy production and smart grids. Fulfilment of high demand in a global market projected to see 30% annual growth, will also represent significant economic benefits for member sta";71429;50000;H2020-SMEINST-1-2014;SME-1;O Skeleton Technologies;EE;;; 194993;654736;EPOCH GeoChem;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Early POpulations in Cretan History: Investigating residential mobility in the eastern Mediterranean using isotope GeoChemistry;1/06/2016;31/05/2018;;"EPOCH GeoChem investigates the Neolithic Transition and the subsequent socio-economic developments on Crete (Greece) using a pioneering, multifaceted methodological approach. For the first time, the focus is on the skeletal remains of the respective people; the tools are cutting-edge isotope geochemistry and radiocarbon analyses; the perspective is bioarchaeological and the methodology is novel for this topic. The main objectives are to: a) investigate residential mobility during the Neolithic to Early Bronze Age on the island; b) refine the chronology of the early human occupation of Crete; c) achieve a nuanced reconstruction of the early Cretan bio-cultural history through in-context interpretation of isotopic data; d) create the tools necessary for this and further research on mobility in Europe and the Eastern Mediterranean. For the first time, isotopic analyses of multiple elements (strontium, oxygen, carbon, nitrogen, sulphur and hydrogen) will be used on the same archaeological human remains, including the earliest yet excavated collection from Crete, to determine geographical origins and diet as proxies for distinguishing between different groups, reconstruct mobility and gain insights into the lifeways and social organization of the respective communities. Radiocarbon dating will provide a clear chronological framework. Through the Fellowship the applicant will create critical new knowledge, an innovative methodology and high quality new data for research into the Neolithic Transition and mobility in Europe and the Eastern Mediterranean; establish lasting cross-border academic networks and collaborations; attain the professional maturity required for leading further research advances; educate the public on the benefits of science and motivate the younger generation. These outcomes fulfill the Horizon 2020 Programmes aims to promote EU excellence through top research and innovation performance across Europe and through a knowledge-based society.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194883;653514;OSEM-EV;SIGNED;H2020-EU.3.4.;GV-2-2014;H2020;Optimised and Systematic Energy Management in Electric Vehicles;1/06/2015;31/05/2018;;Innovation in the automotive industry is of pivotal importance for Europeans prosperity. OSEM-EV will provide solutions for better autonomy and predictable range to address todays car buyers concern about electro mobility. Just increasing the battery capacity is not a viable option because the expectation is to have a familiar level of comfort and safe, eco and human oriented mobility at affordable costs. OSEM-EV will translate the foreseen project innovations into a customer value proposition. The highest priority is improved mileage and predictable range without adding further cost and weight. The negative impact of high and low ambient temperatures will be limited. Cars autonomy will be increased due to a reduction of at least 50% of energy used for passenger comfort and at least 30% for component cooling in extreme conditions compared to current FEVs. The consortium will focus on thermal and coupled electro-thermal energy substitution and harvesting and smart energy usage for cooling and heating of the passenger compartment and in-car infrastructure. OSEM-EV goes for novel electro-thermal architectures and control algorithms including thermal insulation, thermal storage, innovative heating and cooling approaches applied to the powertrain (battery, inverter and motor), battery life duration enhancement as a side effect of thermal management, electronic control of energy and power flows, energy efficiency of electrified accessories, energy substitution and harvesting functions. The consortium will take a radical approach, which does not only rely on improving the efficiency of subsystems but also focuses on their interoperability. By creating an electro-thermal network, most of the energy shall be reutilized, no matter if stored in mechanical, electrical or thermal form.;8002536,25;8002536,25;H2020-GV-2014;RIA;INFINEON TECHNOLOGIES AG;DE;"DAIMLER AG;AVL LIST GMBH;VYSOKE UCENI TECHNICKE V BRNE;SIEMENS AKTIENGESELLSCHAFT;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;VALEO EQUIPEMENTS ELECTRIQUES MOTEUR SAS;HUTCHINSON SA;INTERACTIVE FULLY ELECTRICAL VEHICLES SRL;THE UNIVERSITY OF SHEFFIELD;SAFT;TECHNISCHE UNIVERSITAET DRESDEN";"DE;AT;CZ;FR;IT;UK"; 194832;653184;MPerS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Sustainable Mixed-ion Layered Perovskite Solar Cells;1/04/2015;31/03/2017;;We propose to create and investigate new types of organic-inorganic perovskite materials for low-cost solar cells. The state-of-the-art perovskite based solar cells employ MAPbI3, which has raised concerns over the potential toxicity of Pb. The strategy of the MPerS project is to create, investigate and optimise sustainable perovskite materials for solar cell application. More than one types of metal and organic ions will be introduced in the perovskite structure to realize layered materials which are expected to exhibit both excitonic and free carrier behavior with enhanced stability. Thin films of the new materials will be characterized using several techniques, e.g. Xray diffraction. THz, Time resolved emission spectroscopies, EBIC will be used to understand the generation and dynamics of charge carriers in the materials and across interfaces. Development of solar cells will be carried out with an aim to reach 15% power conversion efficiency employing a non-toxic absorber. This highly interdisciplinary project that spans the field of chemistry, condensed matter physics, electronics and engineering is conceived on basis of the combined expertise of the host and the applicant and state-of-the-art infrastructure at the UOXF. A secondment at Oxford PV will test the commercial viability of the project. This project addresses Horizon 2020s goals on clean and sustainable energy and the EUs concern on toxicology of Pb . Completion of the project will open up new areas in low-cost electronic materials with wider impact and improve EUs competitiveness in materials research. While the applicant will get an opportunity to learn new experimental skills in condensed matter physics and spectroscopy and benefit from industrial exposure. UOXF will benefit from the applicant by using his skills and broader broader collaboration with leading researchers in materials science. A plan is also proposed to carry out public engagement, dissemination and commercial exploitation.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194659;650447;ASTHMAPOC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Disposable nitric oxide POC (point-of-care) test for home care easy management of asthma in chronic patients;1/10/2014;31/01/2015;;"The ultimate goal we seek in ASTHMAPOC project is to develop a ready to the market point-of-care disposable device for self-patient management of chronic asthma. According to WHO statistics more than 235 million people suffer from asthma worldwide. As for all other chronic diseases, effective management of asthma is full of challenges because of the difficulties in determining the appropriate treatment programs and the low adherence to control medications. This typically results in many patients non-effectively prevented from asthma exacerbations and the consequent unnecessary too often visits to emergencies. ASTHMAPOC aims providing a low-cost affordable solution to chronic asthmatic patients for self-management of their disease. Patients who self-test can have a better control over their chronic condition, and make therapeutic, behavioral, and environmental adjustments in accordance with advice from healthcare professionals.
Our approach to achieve ASTHMAPOC goals is to develop a point-of-care device based on disposable electrochemical biosensors capable to determine the concentration of FENO (fractional exhaled nitric oxide). FENO emerged in the last decade as an important biomarker for asthma assessment and management. The clinical utility of FENO has been already validated to the extent that currently there are approved standards in US and EU (further details will be provided in section 1.3). However, only few point-of-care devices have been developed for clinical use (section 1.4), while there is no single product for self-patient management in the market. This niche market is the one we seek exploring with ASTHMAPOC, but in order to be successful in this market we need first to carry out an in-depth feasibility study.";71429;50000;H2020-SMEINST-1-2014;SME-1;TECNOLOGIAS AVANZADAS INSPIRALIA SL;ES;;; 194867;653449;TYPES;SIGNED;H2020-EU.3.7.;DS-01-2014;H2020;Towards transparencY and Privacy in the onlinE advertising businesS;1/05/2015;31/10/2017;;"Online advertising generated in 2013 $42B worth of revenue and more than 3.4 million direct and indirect jobs in Europe in 2012 alone. It supports some of the most important Internet services such as search, social media and user generated content sites. However, the lack of transparency regarding tracking techniques and the type of information companies collect about users is creating increasing concerns in society. Software tools for implementing total mitigation (e.g., ad blocker or cookies blocker) have been released to block any transfer of information from end users towards the online advertising ecosystem. A massive adoption of these tools by end users may cause disruptions in the digital economy by affecting the online advertising sector and leading to consequences such as losing of a large number of employments.
TYPES aims to cope with this challenge by defining, implementing, and validating in pre-market status a holistic framework of technologies and tools that guarantees both transparency and privacy preservation, gives the end user control upon the amount of information he/she is willing to share, and defines privacy-by-design solutions. In particular, these tools should enable the end user: i) to configure the privacy settings so that only the information allowed by the end-user is collected by online advertising platforms; ii) to understand the flow of their information within the online advertising ecosystem and how it is being used; iii) to detect episodes of information collection occurring without consent and identify the offender; iv) to know the value of their data.
TYPES will demonstrate solutions that protect users privacy while empowering them to control how their data is used by service providers for advertising purposes. At the same time, TYPES will make it easier to verify whether users online rights are respected and if personal data is exchanged for a reasonable value-added to users.";4661142,5;3992663;H2020-DS-2014-1;IA;FUNDACIO BARCELONA MEDIA UNIVERSITAT POMPEU FABRA;ES;"NEC EUROPE LTD;UPCOM BVBA;INTERACTIVE ADVERTISING BUREAU EUROPE;ASOCIACION DE USUARIOS DE INTERNET;WEDIA LIMITED;TELEFONICA INVESTIGACION Y DESARROLLO SA;THE OPEN UNIVERSITY*;UNIVERSIDAD CARLOS III DE MADRID;FUNDACION IMDEA NETWORKS";"UK;BE;ES;EL;IL"; 194817;652821;ECOROADS;SIGNED;H2020-EU.3.4.;MG-8.1b-2014;H2020;Effective and COordinated ROAD infrastructure Safety operations;1/06/2015;31/05/2017;;"'The general objective of the project is to overcome the barrier established by a formal interpretation of the two Directives 2008/96/EC (on road infrastructure safety management) and 2004/54/EC (on tunnels), that in practice doesnt allow to perform infrastructure safety checks inside tunnels.
The main problem is that, while from the users (drivers) point of view a road is a unique linear infrastructure generally in open terrain and sometimes in closed environment (tunnels), a strict application of the two Directives leads to a non-uniform approach to the infrastructure safety management outside and inside tunnels.
To overcome this barrier, Ecoroad aims at the establishment of a common enhanced approach to road infrastructure and tunnel safety management by using concepts and criteria of the Directive 2008/96/CE on road infrastructure safety management and the results of related EC funded projects.
Such objective will be achieved through the following specific objectives:
- Workshops with the stakeholders (European tunnel and road managers); Analysis/review of national practices regarding Road Safety Inspections (RSI) and Road Safety Audit (RSA), starting from the results of the 2 studies recently launched by DG Move to assess the impact of the two Directives 2008/96/EC (on road infrastructure safety management) and 2004/54/EC (on tunnels)
- Exchange of best practices and experiences between European tunnel experts and road safety professionals
- Pilot joint safety operations in some European road sections having both open roads and tunnels
- Recommendations and guidelines for the application of the RSA and RSI concepts within the tunnel safety operations
Thanks to the high transferability of the ECOROADS results, the present formal gap (explained in details in the following paragraph) between the Directive 2008/96/EC and the Directive 2004/54/EC will be completely filled and will lead to 'faster, more sustainable and better planned interventions'.'";999500;999500;H2020-MG-2014_SingleStage_B;CSA;FORUM DES LABORATOIRES NATIONAUX EUROPEENS DE RECHERCHE ROUTIERE;BE;"EUROPEAN TRANSPORT SAFETY COUNCIL;EUROPEAN UNION ROAD FEDERATION;SOUTH-EAST EUROPE TRANSPORT OBSERVATORY;ASSOCIATION EUROPEENNE DES CONCESSIONNAIRES D'AUTOROUTES ET D'OUVRAGESA PEAGE;ASSOCIAZIONE ITALIANA DEI PROFESSIONISTI PER LA SICUREZZA STRADALE";"BE;RS;FR;IT"; 195003;654837;EACISD;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-GF;H2020;Embodied and Abstract Concepts in Sensory-motor Deprivation;1/05/2015;30/04/2018;;"How is information organized in the brain? Does our understanding of everyday concepts rely on our perceptual experience, and our ability to sense them? And can this uncover how abstract information is coded in our brains?
These puzzles are at core of cognitive neuroscience and brain organization. Two major theoretical bodies differ in their account of neural concept organization: Classical cognitive theories propose that concepts are symbolic and non-sensory, and are further linked to sensory-motor aspects, whereas embodied cognition theories (e.g. mirror neuron system theory) postulate that concepts are represented only in a sensory-motor manner, and representations depend on the ability to simulate, re-enact, its perceptual process or action.
To address this contradictory account of concepts organization, a systematic interdisciplinary neuroimaging investigation will be conducted in a combination of special populations, each deprived from birth from an entire sensory modality or ability.
The neural correlates of impossible-to-embody concepts will be studied in congenitally blind (e.g. rainbow), deaf (e.g. jazz) and ULD subjects (born without functional hands; e.g. manually handles tools). Brain responses will be analyzed using multiple, state-of-the-art neuroimaging decoding techniques to reveal brain areas representation content and dependence on sensory experience. The neural networks of such concepts will be charted, to investigate the link between abstract thought and sensory inputs. A novel non-linear measurement method to quantity the richness of representations will be developed and applied to the sensorily-deprived groups, to map the dimensions related to specific sensory modalities. At the final stage, these methods will also be applied to study the developing brain in children.
The findings have the potential to revolutionize our understanding of brain organization and pave the road towards rehabilitation of multiple sensory and cognitive deficits.";263385;263385;H2020-MSCA-IF-2014;MSCA-IF-GF;BEN-GURION UNIVERSITY OF THE NEGEV;IL;;; 194765;652114;KIT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Kidney Injury Technology;1/11/2014;30/04/2015;;Bio-inRen has developed and patented a revolutionary biomarker-based diagnostic system for a highly and increasingly incident (>10% yearly) and dismally deadly disease (Acute Renal Failure -AKI) posing a huge global health and economic problem worldwide. Bio-inRens diagnostic system is envisioned to 1) change the concept and approach to AKI clinical handling, 2) become a reference diagnostic, 3) reduce AKI incidence (by 2.5-5% initially) and improve patient prognosis, and 4) reduce the elevated cost associated to AKI (1% of their global health expenditure, which will be reduced initially in 650 M in this 1.35 billion people population). An ELISA-based, clinically useful prototype kit has been developed for measurement of human samples. Clinical validation has started, although Bio-inRens system needs thorough clinical validation to acquire technological maturity and transferability, for which Phase I and II SME instrument are necessary, on which all the companys resources will be laid. As a new concept, Bio-inRens technology has no competitors in the market or under development. The In Vitro Diagnostic Market grows at a 7% annual rate and will reach $69.1 billion by 2017. AKI-specific market is estimated at 3.5 M cases and 70 M diagnostic tests of the existing gold standard marker. Because Diagnostics is a global and regulated market, Bio-inRen will license the system to large companies and SMEs in the IVD market with manufacturing capacity and international commercialization channels. Technology transfer is expected by 2018 to yield 1 M upfront and 5% royalties on sales thereafter. 5% market penetration is sought by 2023. As of today, 5% of 70 M tests poses 3.5 M tests as Bio-inRens market (6.4 M tests by 2023 at 7% annual growth rate). At a unitary sale price of 20 /test, this means 128 M . 5% royalties will produce a yearly income of 6.4 M to Bio-inRen, which are critical for the consolidation and growth of the company.;71429;50000;H2020-SMEINST-1-2014;SME-1;BIO-INREN SL;ES;;; 194665;650502;MONILET;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Monitoring Bracelet for Health Use;1/11/2014;30/04/2015;;"The objective of the project is to further develop and take to market the prototype of the wearable bracelet and cloud based IT platform for 24/7 continuous medical supervision. This is the worlds first wearable health monitoring platform for automated, continuous supervision of pulmonary, heart and sleep related diseases generating preventive alert. This exploits a patented and revolutionary wrist blood oxygen sensing technology called trans-illumination pulse oximetry. Existing systems use a fingertip monitor which is both uncomfortable to wear and has to be connected to bedside or portable machinery and is prone to disconnection and damage in an active environment e.g. on children, and during sleep.

This robustness and ease of use (requiring less medical intervention to set up) will reduce the costs in use. The current prototype (TRL6\ demonstrated in a relevant environment and first clinical trials) needs re-engineering to a more acceptable size as part of the development to a saleable product. It is important for widespread acceptance by patients that the device is small and comfortable and does not look like a medical monitoring device.

The Oxitone bracelet pulse oximetry health monitor continuously measures, processes, transmits and documents patients key vitals taken entirely from the wrist and generates a Dynamic Health Status with minute (60 second) resolution. Oxitones advanced algorithm will enable preventive and emergency alert based on real-time correlative analysis of the key vital signs that includes blood oxygen saturation, pulse rate and variability, breathing rate, skin temperature, medical grade activity and sleep pattern. In addition to the wearable platform we offer an advanced mobile health application and Cloud portal which traces, analyses and alerts patients health status in real time.";71429;50000;H2020-SMEINST-1-2014;SME-1;OXITONE MEDICAL LTD;IL;;; 194713;651171;Pastguide;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Pastguide - guide app to run and witness full 3d reenactments of the past events in the heritage place on your mobile device;1/11/2014;30/04/2015;;"Pastguide is the mobile app that will read tourist user location and will run 3D scene with the events and people who lived in the location in the past. Scenes will match what user sees behind the tablet and his location. Gamified tasks will provide additional learning value. We will feature main European destinations as well as popular places worldwide on global market.

Currently the problem is heritage places offer primitive mobile apps, books and audioguides and with the advent of stronger mobile devices Pastguide intends to make their visit more engaging. There's even larger group of users who can't for various reasons see the places in real life and tourists who want to try virtual samples before they travel. Industry specialists say virtual travel is going to be one of the main trends in future tourism.

There's no solution like this on the market, it holds tremendous potential to show places that disappeared or changed significantly and popular locations. We want to reach out to heritage places to partner with us to promote this app with their locations, let them profit from each download with our partner programme and offer them development of the scene for free.

Pastguide won the EMMInvest Coaching Track funded by the European Commission in 2014 as one of the top 3 graduates.
We have built early prototype that proves it's working on mobile tablet and Oculus RIft. App geolocates user showing him a 3D scene, but we still need to improve accurate matching of what user sees on the tablet with the surroundings and validate the idea with users. Over 200 users signed up for the invite list with us in 2 weeks and we continue to build early traction but we need their feedback on our work. Feasibility study concluding the 1st phase will include: business plan, market fit report, field study results, technology assessment and benchmarked prices. We will also secure first partnerships with heritage sites.";71429;50000;H2020-SMEINST-1-2014;SME-1;FILIPOWIAK JAN;PL;;; 194802;652642;AGRISPIN;SIGNED;H2020-EU.3.2.;ISIB-02-2014;H2020;Space for Agricultural Innovation;1/03/2015;31/08/2017;;"AgriSPIN: creating SPace for INnovation
The project name reflects the overall aim of this project: to strengthen support systems in creating space for innovating farmers.
Innovative farmers are everywhere, but their environment determines the rate of success. The project aims to create more space for innovations, through amplifying good examples of innovation support systems and through multi-actor learning about ways to stimulate innovation and remove obstacles. The main target group is intermediates who connect initiators to other actors for involving them in creating innovations, such as farmers, knowledge workers, actors in the value chain, administrators, civil society groups, etc.
11 European project partners are playing this intermediate role in their regional AKIS. 4 scientific partners complete the team. Each regional partner will host a Cross Visit. The visiting team, composed of project partners, studies interesting cases of agricultural innovations. The scientists provide sound methodology for making these visits valuable.
Throughout the project period partners support each other in an emerging professional innovation network. They inspire each other and initiate improvements in their own systems. The project also addresses the institutional environment, involving public managers, administrators and policy makers.
Case studies and lessons learned are made available to a wider public. Attention will be given to cultural and historical particularities, requiring tailor made solutions for every region. The scientists explore lessons to be generalised and added to the scientific discourse on knowledge brokers.
Once the approach of joint learning through Cross Visits has been well tested and the professional network is functional, the project is ready for collaboration with other partners such as thematic networks and operational groups under the EIP as well as other interested regions in joint learning about innovation support systems.";1994306,75;1994306,25;H2020-ISIB-2014-1;CSA;SEGES PS;DK;"FUNDATIA ADEPT TRANSILVANIA;UNIVERSITAET HOHENHEIM;CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC;ZUIDELIJKE LAND- EN TUINBOUWORGANISATIE VERENIGING;Boerenbondvereniging voor Projecten vzw;VERBAND DER LANDWIRTSCHAFTSKAMMERNEV;LATVIJAS LAUKU KONSULTACIJU UN IZGLITIBAS CENTRS;TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY;FUNDACION HAZI FUNDAZIOA;PROAGRIA ETELA-POHJANMAA RY;Association de Coordination Technique Agricole;INTERNATIONAL FEDERATION OF ORGANIC AGRICULTURE MOVEMENTS EUROPEAN UNION REGIONAL GROUP;AGRICULTURAL UNIVERSITY OF ATHENS;REGIONE TOSCANA";"RO;DE;FR;NL;BE;LV;IE;ES;FI;SE;EL;IT"; 194644;650045;INFINITE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;INNOVATIVE LASER MACHINE FOR INDUSTRIAL ENGRAVING AND 3D TEXTURING;1/10/2014;31/01/2015;;"Created 15 years ago, the innovative Italian company ML Engraving Srl is one of the leaders in laser engraving and texturing on moulds/dies and parts for automotive and consumer goods industries in one of the most industrialised regions in Europe, Lombardia. ML Engraving is also part of the partners alliance Cactooos, The Engraving Network , which gathers the best companies ML Engraving, DS4 and 2 other Italian SMEs (Jockoo and NovaTex) specialized in services connected to the creation and engraving and texturing on moulds.
With INFINITE project, they are developing an innovative laser machine for high precision engraving and 3D surface texturing, fully adapted to these industries in terms of design requirements, productivity, repeatability, easy operability & price. This new technology will allow ML Engraving to consolidate its position in the laser engraving/texturing services (\32% services in 5 years) while extending its business in partnership with DS4 as laser machine supplier for these markets and other production lines industries in Europe and Worldwide (25 million accumulated sales for 2017-2021).";71429;50000;H2020-SMEINST-1-2014;SME-1;ML ENGRAVING SRL;IT;DS4 SRL;IT; 194721;651335;APTOS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;APTOS: industrial scaleup of an Advanced tube forming -Process through Thermal Optimization, enabling energy and manufacturing costs Savings;1/10/2014;31/03/2015;;"The project aims at the up scaling and industrial exploitation of the APTOS manufacturing process which innovatively combines hydroforming and hot tube gas forming of light-metal tubes of titanium, aluminium and magnesium alloys, enhanced with optimized pre-thermal treatment and temperature gradients respectively.
In many forming processes of tubes made by low-formability alloys and/or with complex geometries, about 5 forming stages has to be performed to achieve the final shape, each one requiring the production of different dies and additional pre-heating steps. Within APTOS project, economic and energy savings of the overall manufacturing process (up to 30%) will be achieved by MASPERO, with the suppression of one step in the forming cycle.
MASPERO will exploit in APTOS the results of on-going and previous research projects, for accelerating the innovation and market uptake of the APTOS manufacturing process, which will allow producing pieces with increased geometrical complexity. A fully operational up scaled process will be set up in Phase 2, which will lead for future pre-production series.
A partnership is already supporting MASPERO in Phase 1 and some additional partners will be identified during Phase 1: Politecnico di Milano, Mechanic Department, with great and long experience in advanced forming processes, Fraunhofer IWU of Chemnitz, with a remarkable experience in hot gas forming, and CiaoTech, an European firm active in Economic services for industry.
The potential market of the proposed fully optimized process is enormous as structural and functional shaped light-alloy tubes are used in all kinds of vehicles (bicycles, motorbikes, cars, trains, airplanes, helicopters) and household appliances, kitchenware and other industrial design items, where the lightweight design is a plus. Nowadays, the motorbikes sector is about 19% of Maspero total turnover, automotive 9%, trains 6%, aerospace 2%, kitchenware 3%, with lower percentages for other sectors.";71429;50000;H2020-SMEINST-1-2014;SME-1;FONDERIA MASPERO SRL;IT;;; 194978;654603;FLYELEC;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Quantum Optics with single flying electrons;1/04/2015;31/03/2017;;"In quantum optics, a single photon source as well as a single photon detector is the elementary building block for the manipulation of information coded into a quantum state, a qubit. When combined with beam splitters, polarizers etc., photonic qubits can be manipulated to process quantum information. A well-known example is quantum cryptography, a secure way to transmit information.
In analogy with photons, similar experiments should be possible with single flying electrons in a solid-state device. The advantage of performing quantum optics experiments with flying electrons is the existing Coulomb interactions between the electrons. Photons are basically non-interacting quantum particles and they therefore have a longer coherence time than electrons. However, due to the absence of interactions it is more difficult to construct a two-qubit gate, which operates at the single photon level. This represents a fundamental limitation to the development of quantum computation with photons.
Recent experiments have now demonstrated that quantum optics with single flying electrons is in reach. Indeed, it has been shown that a single electron can be transferred on-demand between distant quantum dots. In these experiments, flying electrons have been transported by a sound wave and high fidelity for single electron emission as well as single electron detection has been demonstrated. This opens the possibility to perform quantum optics experiments with electrons in solid-state devices, which we aim to realize with this proposal. Due to the fact that electrons in solids are strongly interacting particles, new quantum entanglement schemes can be envisioned, not possible with photons.";173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194706;651086;ACfoil;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Anti-counterfeit foil for security packaging;1/10/2014;31/03/2015;;"Problem
More than one million people die each year from counterfeit medicines. 700,000 people in Africa die each year as victims of counterfeit malaria or tuberculosis drugs. The pain is not just financial more than 200,000 jobs are lost due to counterfeiting in the US and Europe alone.

Solution the innovation
Authenticity can be guaranteed by adding holograms to each individual box or bottle of medicine, but costs have so far been prohibitive. Inmold has found a way to mass-produce such holograms at least 100 times faster and 10 to 10,000 times cheaper than current state-of-the-art, and as a small and simple expansion of packaging equipment already commercially available. Inmolds innovation can be both retrofitted and delivered with new equipment.

The project
Inmold has taken out four patents on the innovation, demonstrated a prototype with success with respect to parameters such as price and production speed, and established that there is an interesting market opportunity. However, since the pharma industry is quite conservative it is necessary to show customers customized designs as well as to get feedback from the market on sales and price models, implementation strategies and product features, which is the purpose of the project.

Business model
Inmold and Danapak has formed a collaboration where Inmold supplies production equipment and consultancy to Danapak using a licensing model with profit sharing. Danapak already supplies packaging equipment to the pharma industry and, hence, is a perfect partner for Inmold, who cannot approach the pharma market alone.

Customers and market
The pharma market is very large, yielding a significant packaging market volume of at least 700m. Danapak has a market penetration of 20-35%, depending on segment. Glaxo Smith Kline, Johnson & Johnson and LTS (Lohmann Therapie Systeme) have already shown a keen interest and will deliver feedback to Inmold during the project.";71429;50000;H2020-SMEINST-1-2014;SME-1;INMOLD AS;DK;;; 194895;653749;INSPEC2T;SIGNED;H2020-EU.3.7.;FCT-14-2014;H2020;Inspiring CitizeNS Participation for Enhanced Community PoliCing AcTions;1/05/2015;30/04/2018;;INSPEC2T projects scope is to develop a sustainable framework for Community Policing that effectively addresses and promotes seamless collaboration between the police and the community. INSPEC2T approach bases its conceptual foundations on EU crime prevention and Member States specific Internal Security Policies, validated research results and best practices from cooperation between police and local, regional and national communities. This is perceived as an origin to apprehend special characteristics, particularities and determinants for trust between all stakeholders. INSPEC2T is focusing on a user-centric design and development approach, and has already mobilized and engaged a critical user group mass, in EU and abroad. With special emphasis on social media, it consolidates and modernizes bidirectional communication of stakeholders, using multi-level anonymity flags and having a clear understanding of acceptability issues. Driven from accommodated transnational and multicultural best practices, it adheres to an approach where social, cultural, legal and ethical dimensions are embedded into core user centric design specifications and implementation procedures. INSPEC2T will be demonstrated and validated in 5 EU cities by a wide range of relevant stakeholders. INSPEC2T engagement and active participation is stimulated through fully dynamic, interactive and immersive training Serious Game applications that empower players to familiarize themselves with the system, gain an intuitive understanding of its functionalities and motivate their engagement in Community Policing activities. Special focus will be given to Community Policing awareness raising activities for both police and citizens. The above activities and associated results, will provide a solid foundation for the evolution of the Next Generation Community Policing roadmap in Europe.;4957253,75;4941003,75;H2020-FCT-2014;RIA;KENTRO MELETON ASFALEIAS;EL;"INTRASOFT INTERNATIONAL SA;PlayGen Ltd;THE CHIEF CONSTABLE OF LANCASHIRE CONSTABULARY;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;TRILATERAL RESEARCH & CONSULTING LLP;CGI NEDERLAND BV;IMC DIACHIRISI PLIROFORION KAI EPIKINONION ANONYMOS ETAIRIA;MINISTERIO DEL INTERIOR;ADITESS ADVANCED INTEGRATED TECHNOLOGY SOLUTIONS & SERVICES LTD;TRILATERAL RESEARCH LTD;ETICAS RESEARCH AND CONSULTING SL;FUNDACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES VICOMTECH;AYUNTAMIENTO DE VALENCIA;EXUS SOFTWARE LTD;VIENNA CENTRE FOR SOCIETAL SECURITY - VICESSE, WIENER ZENTRUM FUR SOZIALWISSENSCHAFTLICHE SICHERHEITSFORSCHUNG;SATWAYS - PROIONTA KAI YPIRESIES TILEMATIKIS DIKTYAKON KAI TILEPIKINONIAKON EFARMOGON ETAIRIA PERIORISMENIS EFTHINIS EPE;DEUTSCHE HOCHSCHULE DER POLIZEI;UNIVERSITY OF ULSTER";"LU;UK;NL;EL;ES;CY;AT;DE"; 194746;651675;BioGuidePCa;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Biomarker Guided Prostate Cancer Management;1/11/2014;30/04/2015;;The BioGuidePCa project is designed to validate previously reported biomarkers for prostate cancer (PCa) management during surveillance of early and advanced PCa. With availability of PSA-screening an increase of insignificant PCa has been observed leading to over-diagnosis and overtreatment. Consequently active surveillance (AS) is an alternative to immediate therapy. AS is expectant management with curative intervention only for those patients with local tumor progression. Neuhaus et. al reported a peptide panel, derived from seminal plasma for the estimation of PCa aggressiveness. A main objective of the project is the validation of these biomarkers in regards of its use in AS. On the other hand, advanced metastasized PCa is still a deadly disease. The majority of patients initially responding to therapy progress after a median duration of 30 months. Therapy of castrate resistant prostate cancer (CRPC) relies on hormone therapy and cytotoxic chemotherapy. Recent developments have resulted in novel substances for treatment. However the optimal sequence of the drugs has not been determined. Thus there is a clear clinical need for the development of new approaches for early detection of metastatic disease to guide initiation of alternative therapy. We have recently identified urine based biomarkers, specific for cancer progression. The second main objective of this project is to validate these peptides for their use in assessment of risk of progression and development of metastatic disease. Both biomarker panels will be developed into a non-invasive urine tests for the routine monitoring of CRPC and PCa progression. The study uniquely integrates leading PCa clinical experts with experts on proteome analysis and in an implementation-oriented workflow. The proposed study will provide strong evidence for utility of the new BMs and will set the foundation for diagnostic devices to guide early patient management and personalized therapeutic intervention in PCa and CRPC.;71429;50000;H2020-SMEINST-1-2014;SME-1;MOSAIQUES DIAGNOSTICS GMBH;DE;;; 194852;653350;TARGET;SIGNED;H2020-EU.3.7.;FCT-07-2014;H2020;Training Augmented Reality Generalised Environment Toolkit;1/05/2015;31/10/2018;;"TARGET will deliver a pan-European serious gaming platform featuring new tools, techniques and content for training and assessing skills and competencies of SCA (Security Critical Agents - counterterrorism units, border guards, first responders (police, firefighters, ambulance services civil security agencies, critical infrastructure operators).
Mixed-reality experiences will immerse trainees at task, tactical and strategic command levels with scenarios such as tactical firearms events, asset protection, mass demonstrations, cyber-attacks and CBRN incidents. Trainees will use real / training weaponry, radio equipment, command & control software, decision support tools, real command centres, vehicles. Social and ethical content will be pervasive. Unavailable real-source information will be substituted by AVR (Augmented / Virtual Reality - multimedia, synthetic role players). Near-real, all-encompassing and non-linear experiences will enable high degrees of dynamics and variability.
The distributed Open TARGET Platform will provide extensible standards driven methods to integrate simulation techniques and AVR technology with existing SCA training equipment and be customisable to local languages, national legal contexts, organisational structures, established standard operational procedures and legacy IT systems. At key training points real-time benchmarking of individuals and teams will be instrumented. TARGET will support inter-agency SCA exercising across the EU and act as a serious gaming repository and brokerage facility for authorised agencies to share training material and maximise reuse and efficiency in delivering complex exercises.
TARGET, combining training, content and technology expertise, will be co-led by users and technologists, mainly SMEs. 2 successively developed and trialled versions of the TARGET Solution will support user-technologist dialogue. The TARGET Ecosystem will enable sustainable impact, commercial uptake and synergies at EU level.";5992360;5992359,75;H2020-FCT-2014;RIA;ARTTIC;FR;"ECOLE NORMALE SUPERIEURE;UNIVERSITE DU LUXEMBOURG;OSLO CENTER FOR SCIENCE IN SOCIETY;INSTITUT DE SEGURETAT PUBLICA DE CATALUNYA;ECOLE NATIONALE SUPERIEURE DE LA POLICE;INCONNECT BV;CLEVELAND FIRE AUTHORITY;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;MINISTERIO DEL INTERIOR;ISEM-INSTITUT PRE MEDZINARODNU BEZPECNOST A KRIZOVE RIADENIE, NO;LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY;VectorCommand Ltd;SISEKAITSEAKADEEMIA;ATRISC;INCONNECT VOF;ISCC GMBH;DEUTSCHE HOCHSCHULE DER POLIZEI;Fachhochschule der Polizei des Landes Brandenburg";"FR;LU;NO;ES;NL;UK;DE;SK;EE;AT"; 194771;652206;LAST CHANCE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;New super-energy efficient non-volatile memory manufacturing bringing Europe back on the semiconductor track;1/10/2014;28/02/2015;;"The project will map out the global market and technical specifications for new non-volatile static random-access memory products (nvSRAM) and systems (system on chip, embedded systems) in a feasibility study, including a business plan for the market introduction. ANV, as a fabless company, will prepare an innovative SONOS-module with 90nm-technology for SOC solutions with extremely low power nv memory cells. This is a ground-breaking solution, merging the advanced but dissimilar technologies Logic, DRAM, and FLASH in one cost-effective solution.
The nvSRAM IP blocks offer unlimited and fast (< 20ns access) read and write operation and a reduced energy demand by factor 10,000 compared to a conventional Flash. No comparable solutions on the market provide such scalable high energy efficiencies, application areas and cost saving opportunities. This will enable the target users to integrate low power nv memory into SOC and dedicated stand-alone solutions at competitive prices. Industrial electronics, medical technology products, measuring/sensor technology and data storage/server technology (computing) are the core markets with a fast growing volume of about $150Mn for nvSRAM products and estimated $15.7 Bn for embedded FLASH.
The micro-electronics industry in Europe, comprising research-intensive SME, fabless and producing companies receive competitive SOC solutions for new product innovation in order to step back on the road to success in the semiconductor world.
The feasibility study will assess and prioritize technical specifications for process integration at the production line according to customer needs as well as tasks for production robustness of the new NVSM. It will prove the economic viability focusing on market trends and development of a licensing and IP strategy and elaborate a business plan including pilot products, ROI, risk assessment and financing model.";71429;50000;H2020-SMEINST-1-2014;SME-1;ANVO-SYSTEMS DRESDEN GMBH;DE;;; 194650;650206;TherVIS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;A Thermal-Visual Integrated System Mounted on an Unmanned Aerial Vehicle for 3D energy performance mapping and forecasting and damage evaluation;1/10/2014;31/03/2015;;"Objective of this project is the implementation, validation and demonstration up to the commercial phase of an innovative and flexible device mounted on an Unmanned Aerial Vehicle (UAV), named in the following TherVIS. The device is suitable for: i) mapping energy building performance for energy saving within large extent areas (e.g. building blocks, districts, small communities), ii) evaluating structural health of civilian infrastructures (including bridges, new, old and historical buildings, pipelines, etc.) for public security.
The age of existing buildings is rising and, as a result, they continuously undergo degradation. The improvement of the energy consumption efficiency of buildings and their environmental impacts is a general issue of increasing importance for the construction industry in Europe and all over the world.
For minimizing energy losses TherVIS device is proposed, consisting in a monitoring device integrating a new generation thermal camera coupled with a stereo camera or laser scanning. The monitoring system is mounted on a micro-UAV equipped with different navigation sensors, stabilized by a microcontroller-based flight control and basically operated by GPS navigation or manual remote control. An innovative methodology would be implemented allowing the 3D aerial pictures and thermal images, acquired at a high sensitivity rate, high speed and low frequency, to be automatically integrated in a combined 3D spatial-thermal image within a purposely-built model. Using in situ measured meteorological conditions, the model would allow for quantification of local energy losses and for detection of structural damages of the building. This approach would lead, within large extent areas (e.g. building blocks, districts, small communities) and with a limited number of images (i.e. low operating costs), to: i) an automatic cracking pattern recognition and to ii) a smart 3D spatial-thermal mapping for energy performance assessment.";71429;50000;H2020-SMEINST-1-2014;SME-1;TEA SISTEMI SPA;IT;;; 194872;653497;PANORAMIX;SIGNED;H2020-EU.3.7.;DS-01-2014;H2020;Privacy and Accountability in Networks via Optimized Randomized Mix-nets;1/09/2015;31/08/2018;;"'The objective of the PANORAMIX project is the development of a multipurpose infrastructure for privacy-preserving communications based on 'mix-networks' (mix-nets) and its integration into high-value applications that can be exploited by European businesses. Mix-nets protect not only the content of communications from third parties, but also obscure the exact identity of the senders or receivers of messages, through the use of cryptographic relays. Mix-nets are absolutely necessary for implementing strong privacy-preserving systems and protocols. This project directly aims to realize, integrate and demonstrate the use of a European infrastructure for mix-nets in the context of three diverse high-value applications that have clear, measurable, realistic, and achievable objectives. Our objectives are as follows. (Objective 1): Building a Mix-Net Infrastructure for Europe, by creating a European mix-network open-source codebase and infrastructure, (Objective 2): apply our infrastructure to private electronic voting protocols, where anonymity is necessary to guarantee ballot secrecy, and verifiability is needed for holding fair, transparent and trustworthy elections; (Objective 3): apply our infrastructure to privacy-aware cloud data-handling, in the context of privacy-friendly surveying, statistics and big data gathering protocols, where protecting the identity of the surveyed users is necessary to elicit truthful answers and incentivize participation; (Objective 4): apply our infrastructure to privacy-preserving messaging, where two or more users may communicate privately without third parties being able to track what is said or who-is-talking-to-whom. PANORAMIX facilitates a genuine collaboration between academia, civil society and industry bringing together a team of researchers from academia with a proven track record on privacy technologies and industry in domains where privacy technologies can have a very high impact.'";4459711,43;3796625;H2020-DS-2014-1;IA;THE UNIVERSITY OF EDINBURGH;UK;"TARTU ULIKOOL;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;SAP SE;GREENHOST;VIKINGCO;CENTER FOR THE CULTIVATION OF TECHNOLOGY GEMEINNUTZIGE GMBH;UNIVERSITY COLLEGE LONDON;KATHOLIEKE UNIVERSITEIT LEUVEN;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE";"EE;EL;DE;NL;BE;UK"; 194787;652240;TRACKANT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Mobile Smart Tracking Antenna System for Remotely Piloted Aircrafts;1/11/2014;30/04/2015;;"PIDSO, an Austrian SME holding several patents, specializes in ultra?light carbon?fibre antenna solutions for diverse applications e.g. in the automotive sector.
Based on its outstanding antenna technology know-how, PIDSO recently has developed an innovative communication and control system for Remotely Piloted Aircrafts (RPAs), which is - compared to competitive solutions - significantly lighter and smaller allowing to mount it on RPAS creating the opportunity for using one RPAS as a relay station for another RPAS thereby dramatically increasing range as well as data transmission features. This provides the missing technological base for Beyond-line-of-sight navigation needed to cross through areas with obstacles like buildings in cities or diverse topographical factors. This will pave the way to deploy RPAS for public safety applications (disaster, rescue, ) or precision agriculture (maturity measurement, crop control, disease detection, fertilizer deployment), both unfolding huge commercial and societal impact. Our system is an innovative ICT solution building on a proprietary hardware and electronic construction (antenna, hybrids, 2-axis gimbal, motor-control, contactless rotary joint) plus a highly-sophisticated software consisting of initialization, tracking algorithms, stabilization and closed loop motor controls based on existing and newly developed models, position and direction finding and power management. Our project fits perfectly with the development and business strategy of PIDSO as well as with the requirements of this SME call, adding a completely new, market changing solution.
Specific objectives for the feasibility study include field tests with three test partners, in particular RPAS manufacturers, to collect feedback from the primary business opportunity fields to be fed into fine-tuning of the solution to get our product from current to TRL9, building up cost models for production and elaborating a detailed business and market entry plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;PIDSO -PROPAGATION IDEAS & SOLUTIONS GmbH;AT;;; 194629;649867;STEAM-UP;SIGNED;H2020-EU.3.3.7.;EE-16-2014;H2020;STEam And Management Under Pressure;1/03/2015;28/02/2018;;"The industrial sector could reduce its energy use by at least 13%. 75% of the potential savings can be found in steam and electric motor systems. Actions to tap the full potential in steam systems have been taken in the past but without success since findings from energy audits were not, or partly, implemented.

The following barriers have been identified:
? There is no business case for steam saving measures for enterprise decision makers;
? There is a lack of technical (steam) expertise of energy auditors and within enterprises generally;
? There is no formal organisational structure for dealing with energy efficiency (energy management).
The objectives and goals of the STEAM-UP proposal are:
Bridging the gap between audit results and implementation by developing an in-depth steam audit covering:
? state of the art steam expertise;
? involvement of all stakeholders in the enterprise;
? identification of non-energy benefits to strengthen business cases;
? energy management to secure prolongation.
Reducing the effort for measure implementation by developing an integrated solution for business case reporting and energy management implementation.
Achieve energy savings during this action of 55,6 GWh/a through piloting 75 of the in-depth steam audits.
Building capacity amongst 400 energy auditors for the use of the in-depth steam audit methodology in their daily practise.
Building capacity amongst stakeholders in 75 enterprises on steam and the business benefits to increase steam efficiency.
Building capacity amongst 40 energy management training providers to enable integration of the in-depth steam audit methodology in regular energy training programmes.
Promote knowledge transfer on steam and the benefits to increase steam efficiency.
This project focuses on the large, energy-intensive industry but the methodology will also be applicable for SMEs. The developed methodology can be made applicable for a wide range of utilities and processes.";1503105;1503104,5;H2020-EE-2014-3-MarketUptake;CSA;INDUSTRIAL ENERGY EXPERTS BV;NL;"AURA RADGIVNING AS;ISNOVA ISTITUTO PER LA PROMOZIONE DELL' INNOVAZIONE TECNOLOGICA SCARL;ADELPHI RESEARCH GEMEINNUTZIGE GMBH;CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;OSTERREICHISCHE ENERGIEAGENTUR AUSTRIAN ENERGY AGENCY;CONSUL SYSTEM SPA;MINISTERIE VAN ECONOMISCHE ZAKEN;ENVIROS SRO;ESCAN SL";"DK;IT;DE;EL;AT;NL;CZ;ES"; 194880;653639;KMET-READ;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Reading of lysine methylation discovery, biological function and application;1/10/2015;30/09/2017;;Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. Recently, it was also shown to influence the stability and activity of non-histone proteins. Lysine methylation marks manifest their biological effect via so-called readers (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. Reading domains include Plant homeodomains (PHD) and Chromodomains (CD) found in many chromatin proteins. KMET-READ plans to investigate the biological role of these reading domains in essential histone lysine methyltransferases - PHDs in MLL2 and MLL3 and CDs in SUV39H1 and SUV39H2. The results obtained here will advance the understanding of chromatin changes in human cells. The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). Importantly, the KMET-READ project will also develop a yeast-3-hybrid method for the identification of new reading domains, which will allow to discover binding partners for just recently characterized new protein methylation marks. This novel method will be patented and introduced into market. All project partners will ensure an efficient dissemination and communication of the results of the KMET-READ project. The project will provide excellent training in research methods and other skills for the fellow that will strongly support her future career and initiate new and sustainable collaborations between the partners.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;Universitaet Stuttgart;DE;;; 194857;653383;IMPACT;SIGNED;H2020-EU.3.7.;DRS-21-2014;H2020;Impact of Cultural aspects in the management of emergencies in public Transport;1/05/2015;31/10/2017;;"The objective of the IMPACT project is to investigate the essential role played by cultural factors in managing safety- and security-issues related to emergencies in public transport systems.
The IMPACT Coordination and Supporting Action is aimed at analysing the different cultural behaviours for the prevention of emergencies with particular emphasis on risk and situational awareness perception of the different cultural groups; information to passengers with different socio-cultural backgrounds; cooperation towards prevention of security threats; security checks.
Moreover, it is aimed at analysing the different cultural behaviours for the management of emergency events and the post-events with particular emphasis on: crowd management; management of first responders to care for different cultural groups; information to passengers.
From the above analyses IMPACT will produce a cultural risk assessment methodology and the associated mitigation actions for the public transport sector also developing simulators and models; identify innovative solutions that can support public transport operators in improving the communication with passengers through tailored messages to the different cultural communities (via mobile phones and social networks) and other solutions to enhance the management of emergencies considering cultural aspects; develop best practices, dedicated training material and procedures for both public transport operators and first responders; develop policy recommendations for policy makers, regulators, municipalities and public transport operators.
The IMPACT Consortium has an intercultural and interdisciplinary approach with an extensive expertise in different disciplines, ranging from social and cultural psychology, sociology and anthropology, to safety, security and emergency management and from computer-science to communication and event organization. The consortium is composed by 2 SMEs, 1 big Industry, 4 Universities and 1 National Authority.";1398912,5;1398912,5;H2020-DRS-2014;CSA;DEEP BLUE SRL;IT;"STICHTING VU;NUOVO TRASPORTO VIAGGIATORI SPA;VISSHE UCHILISHTE PO MENIDZHMANT;ANADOLU UNIVERSITY;UNIVERSITY OF LEEDS;PROPRS Ltd.;URZAD MORSKI W GDYNI";"NL;IT;BG;TR;UK;PL"; 194689;650793;InlinePlat;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;InlinePlat - Innovation in metal coating through automatic high speed electroplating units, process intensification and closed water cycles fully integrated with mechanical manufacturing lines;1/11/2014;30/04/2015;;"By realising a very high process intensification of the electrochemical metal deposition process, the InlinePlat project aims to develop and bring to market modular, fully automated production units for electroplating of mechanical parts and components which can be directly integrated into the manufacturing lines of mechanical engineering companies, automotive suppliers, components and systems manufacturers etc. as self-standing functional metal coating systems. Compared to the very high degree of automation and production integration of the machining, assembling and other mechanical manufacturing processes, the electroplating processes still have a very high potential of optimization in terms of process efficiency, reduction of logistics, increase of automation and production integration.
The business concept of the InlinePlat project breaks up with the old electroplating business model i.e. maximum flexibility of electroplating plants and integrates fully automated electroplating units as product specific manufacturing cells directly into the production line of a mechanical manufacturing company. The units will be reconfigurable so that the InlinePlat concept will support the concept of the reconfigurable factory. The automated electroplating solution shall reduce the high labour costs and use the existing staff for more sophisticated, higher productive work. Costs will further be reduced by substantially improved resource efficiency (energy and materials) and effluent free operation with limited exhaust air emission; this will allow to install the InlinePlat units without any individual environmental permission. Hence, integration of InlinePlat units into manufacturing lines should be no more complicated than any manufacturing machine, so that the benefits of modern process automation with advanced control options, integration to overall factory control systems, and substantial reduction of logistical effort can be full derived.";71429;50000;H2020-SMEINST-1-2014;SME-1;LUDY GALVANOSYSTEME GMBH;DE;;; 194837;653223;USIFlux;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Unveiling Stomata 24/7: Using Stable Isotopes and COS to quantify diurnal and nocturnal carbon and water vegetation-atmosphere Fluxes under future climate scenarios;1/04/2016;31/03/2018;;Rising atmospheric CO2 concentration, increasing temperature and altered precipitation patterns dramatically impact the terrestrial biosphere with important consequences for all biogeochemical cycles. Predictions of carbon (C) and water exchange between vegetation and the atmosphere require detailed mechanistic understanding of how plants control water loss and C gain through their stomatal pores. Currently, global circulation models incorporate formulations of stomatal conductance (gs) based on stomatal optimisation theory. However, these models ignore gs regulation: (1) during night time, despite clear evidence for significant nocturnal transpiration, (2) in non-vascular plants and (3) during leaf development and senescence. To reduce the uncertainty associated with current C and water fluxes in models, we need to incorporate robust predictions of gs in response to novel environmental conditions (higher temperature, decreased water availability and elevated CO2). To fill these gaps, USIFlux, will develop a novel tracing technique to measure gs during the dark, when fluxes are an order of magnitude smaller than during the day. To do so, we will combine measurements of COS (carbonyl sulphide) uptake with CO18O fluxes and changes in the oxygen isotope composition (?18O) of water in leaves. We will relate the response of gs at night to changes in gs during the day and in response to drought and elevated CO2. These measurements will be coupled to an experiment to investigate stomatal regulation during leaf ontogeny and in different life forms. Here, we will challenge the stomatal optimisation theory in life forms lacking active stomatal control (mosses and brackens) and during leaf development, when leaf construction costs constrain the optimisation of C gain. Empirical formulations arising from these experiments will be incorporated into large-scale soil-vegetation-atmosphere transfer models to explore their impact at larger scales.;173076;173076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;;; 194756;651901;Toor-IG-ICT37-2014;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Enabling mass access to the social phenomenon of e-sports tournaments by integrating In-Game Platform in worlds leading video games;1/10/2014;31/03/2015;;"A new universe of video game tournament (called e-sports) has transformed dramatically the video game industry over the last two years. However, organising and participating in e-sports tournaments remain complicated for players and publishers. OXENT wants to support and amplify this massive growth of e-sports by integrating an e-sports platform directly in top selling video games (so-called in-game approach).

The current state-of-the-art reveals that no in-game tournament solution exists. With its innovation, OXENT wants to change the way video games are played, with a massive shift towards tournaments among the average player. OXENT aims to become the world leader of e-sports tournament technology with 34 million income in 2017 and 20 employees.

Our BtoBtoC solution meets the needs of both players and of publishers. Direct integration into video games democratises the use for players, by giving access to the platform automatically and intuitively. Publishers will easily shift from single sales business model to subscription. Therefore, client retention will increase, and the games life cycle will be extended. In addition, new sources of revenue will be created through tournament fees.

The feasibility study will assess three key levels:
1. Technical: Test in-game performance and improve design and ergonomics.
2. Economic: Define the business model through meetings with global publishers and potential business partners
3. Legal: Identify data collection legal issues and the opportunity to protect our knowledge.
For global commercialisation of our innovation, total funding requirement during 2 years for Phase 2 is estimated at 2 800 000.

The dissemination of the innovation will be global. For cultural and market size reasons, target geographies for video game players include the major European markets in France, Germany, UK and the Scandinavian countries, as well as in North America. These countries, combined, comprise 60% of the global market.";71429;50000;H2020-SMEINST-1-2014;SME-1;OXENT;FR;;; 194963;654386;FUTURES;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Energy Futures of the High North: Assessing Intermediary Expertise and New Valuation Practices that Guide Arctic Hydrocarbon Development;1/06/2016;31/05/2018;;"I will undertake research assessing the role of intermediaries (consultants) in creating Arctic energy futures and utilize a training plan of Professor Markku Kivinen, Director, Aleksanteri Institute, U Helsinki, in order to transition into a globally recognized leader of Cultures of Expertise frameworks for scholars involved in the anthropologies of finance, futurity and expertise, linked to Science and Technology Studies-related genealogies. I want to improve the state of theory and knowledge in relation to how intermediaries engage in valuation practices that drive the location and content of pivotal conversations on Arctic oil and gas extraction. Two patterns of development will be addressed: the increasing visibility of Arctic energy futures as detailed expectations that represent strategic resources for attracting attention from (financial) sponsors to stimulate agenda-setting processes; and, the rise of intermediaries suggesting a trend towards greater control over access to Arctic knowledge that is privatized via commodification. Research objectives include building a conceptual terminology and typology of the kinds of assessments that consultants produce, further developing alignments at the intersection of proprietary practice and multidisciplinary analysis. I will combine data collection at two consulting firms and at six key networking events with a training secondment at Regional Council of Lapland in order to pilot industry and policy relevance. My US National Science Foundation research will create EU knowledge transfers for the systematized study of intermediary experts and Arctic energy futures through graduate supervision and symposiums leading to four peer-reviewed journal articles and a co-edited volume. Supervised training on science management involving Institute decision-making procedures, raising my profile through high h-index journal publications and advisory responsibilities will increase my prospects for securing a tenured professorship.";179325,6;179325,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;HELSINGIN YLIOPISTO;FI;;; 194731;651495;HiCompost;TERMINATED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Novel business based on high efficiency composting technology;1/11/2014;30/04/2015;;"There is a trend towards encouraging biowaste management companies (solid waste and waste water treatment plants) and biowaste producers (shopping centres, food manufacturers, agricultural cooperatives and farms) to invest in composting plants in order to improve the treatment of organic waste. Additionally, laboratories are also installing composting facilities focussed on biomaterials testing taking into account that these materials, whose production is increasing year by year, need to be validated with regards to compostability requirements.
Nevertheless, the composting technologies currently used by each of the three sectors present some drawbacks. Biowaste producers and managers use composting systems which needs large treatment areas and long times, produces compost not always compliant with quality standards and generates several problems such as low lixiviate control, fire risks and bad odours. Regarding labs, they need to adapt their facilities to the technical requirements of the compostability tests carried out, which generates high costs related to the time invested by technicians in making facilities compliant.
BASTAN has been working on the design of composting technology to solve these limitations. These composters permit to reduce composting times, minimize investment and production costs, control process parameters and lixiviate generation, reduce bad odours and fire risks, as well as guarantee the required quality in the final compost.
Therefore, the objective of the HiCompost project is to design and implement a business plan focussed on the broad penetration of BASTAN composters in these three market segments. This business plan will be based on three pillars: (1) technological improvement in comparison with traditional composting systems; (2) innovative service based on composting know-how adapted to each client; and (3) technology validation based on the technology alignment with the requirements on compost quality and testing.";71429;50000;H2020-SMEINST-1-2014;SME-1;HIDROMECANICA J. BASTAN SL;ES;;; 194741;651636;EFFGT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Aurelia Turbines proof of concept for very high efficient small gas turbine;1/10/2014;31/03/2015;;"The EFFGT project aims to develop a feasibility study and all the elements needed for a comprehensive business plan to Aurelia Turbines Oy for selling very high efficient micro gas turbines (microturbines).

Aurelia is a Company that has been established to commercialize microturbine developed by Lappeenranta university of Technology / Finland (LUT). The microturbine has a nominal power output of 450 kW with a net electrical efficiency of 45,8%. This is more than with any existing technology in this class. Furthermore, the easy recovery of excess heat from clean exhaust gas makes the microturbine well suitable for almost any combined heat and power (CHP) application. This microturbine has the possibility to be a real game changer of the decentralized power generation and CHP.

In this project a strong focus is being given to determine the end-customer needs and expectations, sales network, cost structure and overall financial planning of the company. The technical development of the microturbine itself will be conducted by LUT.";71429;50000;H2020-SMEINST-1-2014;SME-1;AURELIA TURBINES OY;FI;;; 194988;654724;GROUPCOG;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;From individual cognition to collective intelligence;1/04/2016;31/03/2018;;In many taxa, individuals form groups that collectively process information and make decisions. Through pooling information, these groups can theoretically achieve better decisions than solitary agents. However, it has become increasingly clear that understanding successes and failures of collective decision-making requires a detailed understanding of individual cognitive abilities and of information transfer among group members. I would like to build on my background in social insect collective behavior to investigate a longstanding question in complex systems science: when and how does collective intelligence emerge from individual cognition? I propose to elucidate this issue using novel experiments with homing pigeonsa species that has numerous advantages as a model system. First, pigeons can process information both individually and collectively. When flying alone, each pigeon establishes idiosyncratic habitual routes over time, based on memorized chains of landscape cues. Flocks of pigeons are also collectively able to develop distinctive routes. Thus, I can directly compare the cognitive performance of individuals and groups by giving them the same spatio-cognitive tasks. Second, as pigeons have been among the most important subjects in laboratory experiments on animal cognition, a wealth of data is available on pigeons individual cognition. Finally, cutting-edge GPS devices provide high-resolution spatiotemporal data, allowing me to create and validate highly detailed individual-based models. My results will be applicable to multiple research fields, including optimal decision-making theory and collective robotics.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194716;651226;VIPREP;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;MAGPIE POLYMERS: Vertical Integration into PGM Refining Processes;1/10/2014;31/03/2015;;"Magpie Polymers, a start-up founded in 2011, produces proprietary filtration technology with extreme selectivity and high performance in difficult to treat waste or process water. Selectively removing metals from complex effluents creates value for industries dealing with precious metals such as palladium, platinum, iridium, rhodium and gold. The main focus of commercial development of the SME is the precious metal refining industry, with growth potential in precious metal mining.

Whereas initial sales of Magpie Polymers' technology are made for the treatment of waste-streams to recover the last traces of precious metals, in the innovation program VIPREP, the SME aims to accelerate growth by integrating vertically into refining processes.

Vertical integration for Magpie consists in adjusting and improving its unique technology so that it can be used upstream in the refining process of the customers. The drivers for this vertical integration are speeding-up the refining process and decreasing the loss of precious metals at each step. Magpie's resins are furthermore easy-to-handle and non-toxic, contrary to the reagents currently used in the industry.

Vertical integration of the unique filtration beads that selectively bind platinum group metals will translate to a 20x larger accessible market for the SME, stronger customer engagement and creation of higher added value for the user.";71429;50000;H2020-SMEINST-1-2014;SME-1;MAGPIE POLYMERS SAS;FR;;; 194784;652599;InnProBio;SIGNED;H2020-EU.3.2.;ISIB-07-2014;H2020;Forum for Bio-Based Innovation in Public Procurement;1/03/2015;28/02/2018;;"InnProBio aims to build a community of public procurement practitioners interested in Public Procurement of Innovation (PPI) with Bio-Based Products and Services (BBPS). The community will be supported by online network facilities.
Based on stakeholder identification and needs assessment the project consortium will develop an elaborated and legally solid toolbox which will assist public procurers to inform themselves about BBPS and ultimately provide all relevant information to prepare an actual tender. The toolbox will be used for capacity building activities including trainings for public procurers and decision makers, market dialogues and exchanges with standardization experts. It will furthermore be presented in an online decision support tool and a multilingual handbook. The workshop and dialogue concept for trainings can subsequently be used throughout Europe.
Recommendations for decision makers and standardization bodies on how to support PPI of BBPS in order to boost innovation in Europes bioeconomy will be provided. Feasibility of an cross-national buyers group of public procurers on the innovation procurement of BBPS will be assessed.
Based on a dissemination and exploitation strategy, project results will be communicated through various channels to the relevant target groups (public procurers, public decision makers, business, standardization bodies and NGOs).
Specific groups will be set up on the Procurement Forum (www.procurement-forum.eu). The community will be one channel to share and distribute project results.
Via the integration of the project and its products into the existing Procurement of Innovation Platform (https://www.innovation-procurement.org/), the project results will be sustainable. Integration of the bio-based products section is a win-win situation for the existing platform and for the bio-based products sector who as a newcomer can profit from existing infrastructure and knowledge.";1971805,75;1964868,5;H2020-ISIB-2014-1;CSA;Fachagentur Nachwachsende Rohstoffe e.V.;DE;"STICHTING NEDERLANDS NORMALISATIE - INSTITUUT;B.T.G. BIOMASS TECHNOLOGY GROUP BV;NOVA-INSTITUT FUR POLITISCHE UND OKOLOGISCHE INNOVATION GMBH;MINISTERIE VAN ECONOMISCHE ZAKEN;ICLEI EUROPEAN SECRETARIAT GMBH (ICLEI EUROPASEKRETARIAT GMBH)*;UNIVERSITY OF HULL;UNIWERSYTET LODZKI";"NL;DE;UK;PL"; 194948;654198;NONNH;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Mechanism of hydrogenation and transfer hydrogenation of polar unsaturations catalyzed by non N-H systems;12/07/2015;11/07/2017;;The project addresses the reduction of polar unsaturations catalyzed by metal complexes under strongly basic conditions. This is an important reaction that enters the manufacture of many high added value fine chemicals. The role of the strong base for catalysts that do not contain active protons in the ligand donor functions is unclear, as well as the relationship between the mechanisms of hydrogenation by H2 and transfer hydrogenation. The sought mechanistic understanding can lead to the design of improved catalysts and operating conditions. The project will be implemented by a multifaceted approach that includes synthesis, characterization, catalysis, kinetics, and computations and be further enriched by parahydrogen NMR studies through a 3-month secondment at the University of York. This multisectorial training will put the ER on an excellent basis to further develop his professional career in research. The ER has an excellent basic training from one of the premier institutions in his Country and an outstanding publication record. The ER will be expected to mentor undergraduate students in the group, to deliver 4 presentations at group meetings, to present his results in at least one international conference and to contribute to drafting research publications. The project is expected to lead to high impact fundamental knowledge resulting in high quality publications, presentations at international conferences, and popularized articles in University magazines.;185076;185076;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194697;650854;VSM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Validated Surge Model;1/10/2014;31/03/2015;;"Filton Systems Engineering (FSE) intends to establish methodologies, which have been verified using test data, to provide validated accurate surge pressure predictions within aircraft fuel systems. This would replace physical Aerospace Test Rigs with a virtual test rig to reduce development cost and lead-time by improving the robustness/integrity of surge/ two phase flow fluid modelling. This allows aerospace companies to optimise architecture early in the design phase minimising installation and structural weight, increasing aircraft efficiency, thereby lowering operating cost and also reducing carbon footprint.
Commercial realisation of the programme is through the sale of services/methodologies to aerospace customers and also potentially through the sale of validation test data to software houses to improve their marketing position relative to claims for predicting surge pressures; and the expansion of methodologies to cover fluid applications in other industries.
FSE is uniquely positioned to succeed within this task due to existing surge analysis, test management and rig specification capabilities which will also protect further work that develop from this programme of work.
The feasibility study undertaken under Phase 1 will comprise:
1. IP investigation
a. Current IP for similar methodologies
b. Use of IP to protect methodologies
c. Use of copyright to protect data
2. Potential commercial arrangements with final customers
a. Requirements
b. Use of data, services & methodologies
3. Potential commercial arrangements with software house
a. Support for commercial code
b. Use of validation test data
4. Statement of Work for Phase 2 (inc. plan & budget)
5. Top level test facility requirements
6. Top level test requirements
7. Produce Comprehensive Feasibility Report
If Phase 1 is successful, further funding will be applied for under Horizon 2020 Phase 2 with FSE providing the balance of the funding. It is estimated that Phase 2 will take a further 2? years.";71429;50000;H2020-SMEINST-1-2014;SME-1;FILTON SYSTEMS ENGINEERING LTD;UK;;; 194614;649743;STORM;SIGNED;H2020-EU.3.3.1.;EE-13-2014;H2020;Self-organising Thermal Operational Resource Management;1/03/2015;31/08/2018;;"In STORM a generic district heating and cooling (DHC) network controller will be development and demonstration, with the ambition to increase the use of waste heat and renewable energy sources in the DHC network.

The general applicability will be guaranteed by the following measures:
- Applying self-learning control techniques instead of model-based control approaches, will make the controller easy to implement in different configuration and generations of DHC networks.
- Three control strategies are included in the controller (peak shaving, market interaction, cell balancing). Dependent of the network, one or more of these strategies can be activated.
- The controller will be an add-on to many existing DHC network controllers and SCADA systems.

To present this general applicability, the controller will be demonstrated in two existing grids: one highly innovative low-temperature DHC network In the Netherlands and a more common medium-temperature district heating grid in Sweden.

Since additional value is created by applying the control strategies in the controller, innovative business models should be developed to distribute this value amongst the different market players (producers, transporters, consumers of energy). This will also be addressed in the project.

Also a plan will be developed on how the developed controller can be replicated to other countries than the ones of the demonstrators, taking into account different market organizations and legal framework.

With respect to dissemination two levels of dissemination will be applied. A international dissemination will address the international research community, DHN network controller suppliers, international energy companies etc Besides that, an additional local level will be implemented where two local dissemination platforms will be installed integrating all local stakeholders (the energy company, users, local educational institutions, local politicians). Special attention is foreseen for education.";1972125,94;1972125,94;H2020-EE-2014-2-RIA;RIA;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.;BE;"SIGMA ORIONIS SA;STICHTING ZUYD HOGESCHOOL;EUROHEAT & POWER;VAXJO ENERGI AB;MIJNWATER BV;NODAIS AB";"FR;NL;BE;SE"; 194676;650657;MIGOSA;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Modified Internal Gate image sensor for low light optimised Out-door Security surveillance Applications;1/11/2014;30/04/2015;;"In todays cameras the photographic film has been replaced by image sensors, which are silicon chip transforming light into digital images. The image sensors have large amount of pixels measuring locally the amount of light impinging on the pixel and jointly forming the digital image. The image sensors are manufactured like any other silicon chips in foundries having clean rooms and sophisticated silicon processing tools.

So far there have been two different ways to readout the pixel specific signal, namely, External Gate (EG) configuration utilized e.g. in present Charge Coupled Device (CCD) and Complementary Metal Oxide Semiconductor (CMOS) image sensors as well as Internal Gate (IG) readout configuration that is prone to manufacturing issues and consequently its use is extremely limited. The EG was invented in the sixties and the IG in the seventies. The problem with both of them is that they suffer from non-optimal low light performance.

Pixpolar has invented, developed, and patented (more than 20 patents are already granted) a third fundamentally new image sensor pixel readout configuration called the Modified Internal Gate (MIG) that provides superior low light performance when compared to the two other older technologies.

The MIGOSA project comprises three different tasks. The first one is business plan development work comprising meetings with potential customers in order to ensure that there is sufficient need for the MIG technology and that the development work fulfills customer needs. The second one is an Intellectual Property Right (IPR) study to be performed in order to investigate whether there are any IPR obstacles for MIG image sensor manufacturing. The third one is a manufacturability study performed by the chosen foundry in order to find out whether our pixel design complies with the foundrys manufacturing process.";71429;50000;H2020-SMEINST-1-2014;SME-1;PIXPOLAR OY;FI;;; 194661;650473;General Purpose DP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;A Compact Dynamic Positioning System of General Purpose for Marine Units, Crafts and Ships;1/07/2014;31/12/2014;;"Operation of floating units in the sea often requires the units to maintain position, as for instance in the rescue after a ship wreck or when assisting a wind farm. Due to the stochastic behaviour of the sea, Dynamic Positioning (DP) Systems accurately automate this task reducing the risk of human error. However, current DP1 systems in the market evolve from those used in the Oil&Gas, which are highly redundant and expensive.
Seaplace has designed seaDP-1C, a DP1 System with the operator station and the real time controller in a single CRIO 908X unit. This compact system is cheap, robust, requires little space, and provides great flexibility due to its modularity. Our DP will come with a smart green autopilot, which, by filtering waves, corrects accurately the drift course, reducing consumption by 1 to 3%. With SeaDP-1C we will generalize the use of smart control and manoeuvring, offering an affordable product and reaching the niche market of the most technological units.
As a naval architecture firm with 34 years of experience, Seaplace knows many different players of the marine sector interested in seaDP. Shipyards and yacht manufacturers can choose the provider of a system among those approved in the makers list, and ours will offer a great price. Providers of propulsion systems and electronic installations without DP will use the modularity of our system to offer turn-key projects. Shipowners without DP will also install our system because of its price and consumption reduction.
In Phase 1 we will confirm the costs, the market opportunity and plan the implementation. In Phase 2 we will build and check the real product, install it aboard, and get the Class Approval so that we can start selling it, which will convert us onto a high-growth company: in the 3rd year our turnover will increase by 6 million .
Through our system the EU will get a feasible way to increment the safety at sea, allow more efficient operations and minimize fuel consumption and emissions.";71429;50000;H2020-SMEINST-1-2014;SME-1;SEAPLACE SL;ES;;; 194701;650832;AirWatt;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Feasibility study of a microturbine for delocalized electrical energy, off-grid generation;1/10/2014;31/03/2015;;"Advanced Microturbines S.r.l. developed a microturbine for local generation of electricity from pressurized gases, in the range of 20-50W. The present study will evaluate the feasibility of energy storage and supply system for off-grid applications, based on the microturbine technology, characterized by being low costs, low carbon, flexible, robust and easy to maintain. From a business standpoint, the market need for a similar device was realized by the experience of the proposer in the oil&gas industry. In this context, having a local and distributed energy generation in smart distribution grids represents a potential for cost saving and performance improvements: for example, leakages can be detected by distributed sensors and information sent via wireless transmitters, powered by the microturbine. The microturbine can be used in two operating modes:
As micro-turbo expander exploiting available pressure drops for generating electricity to power up delocalized sensors and transmitters.
As air-powered generator, supplying critical loads for short periods, taking energy from a pressurized tank.
Three main objectives shall be reached during the feasibility: a first validation of the technical concepts, a detailed picture of the markets (smart distribution grids, remote off-grid repeaters and possible niches) and a refined business model and plan. On these results, Advanced Microturbines S.r.l. is willing to base the application for phase2. In line with its objectives, the study will include the following activities:
Analysis of the technical scenario and concept design: trends and current IPR scenarios, preliminary list of technology suppliers and potential future partners. Study of the markets: trends, Porters 5 Force analysis, strategy for market entering. Business model, business plan and action plan towards phase2: main technical and economical conclusions, inputs for the final deliverable, detailed technical development plan for phase2 and after.";71429;50000;H2020-SMEINST-1-2014;SME-1;ADVANCED MICROTURBINES SRL;IT;;; 194750;651788;QUALIGRAIN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Increasing grain quality through advanced oxidation treatment during storage;1/09/2014;31/01/2015;;"Our company, La Sanfermese, with more than 200 year experience, is specialized in the clearing, drying, storage and commercialization of cereals, in particular maize and wheat. Our main products are white maize, yellow maize, flint maize, durum wheat, peeled durum wheat and calibrated durum wheat coming from non-genetically modified crops (non-GMO) in the Po Valley (Italy). Our main customers are mills and producers of grain-based derivatives. La Sanfermese has an annual storage capacity of 80.000 tons of maize and 40.000 tons of wheat.
Since the application in September 2008 of the EC Regulation N 396/2005 on maximum residue levels of pesticides in or on food and feed of plant and animal origin, the cleaning of the grain is only performed by mechanical methods, as the most effective synthetic chemical insecticides available for the protection of stored product, such as phosphine, are now banned. On the other hand, EC regulation regarding maximum levels for contaminant in foodstuffs as regards Fusarium toxins (mycotoxin) are every time more stringent, as the new limits set by the EC Regulation N 1881/2006 for maize and maize products.
This means that, in case the crop has been contaminated during the harvest with insects or fungi (mycotoxins) we have no possibility to eliminate this infection. Furthermore, this situation can get worse during the storage, as once the grain has been infected, the microorganism can grow influence by parameters such as moisture and temperature. In this case, the maize will not be longer suitable for human use and we will have to sell it for zootechnical or industrial purposes (depending on the mycotoxin content), with the corresponding differential price (45 ton).";71429;50000;H2020-SMEINST-1-2014;SME-1;LA SANFERMESE SpA;IT;;; 194646;650169;LIRON-2020;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Disruptive Technology for the Global Laundry Equipment Market;1/10/2014;31/03/2015;;"LIRON 2020 addresses the Multi-Billion global market for domestic laundry equipment with a highly innovative, disruptive technology that will revolutionise the industry and provide significant economic, lifestyle and environmental benefits.

There are an estimated 840 million domestic washing machines in use worldwide, with predictions of 36% growth by 2020 and 62% by 2030. Together, these washing machines account for approximately 2% of the total residential sector electricity consumption and utilise about 19 billion cubic metres of water per year.

With energy and water prices soaring there is a constant drive towards more energy- and water-efficient laundry technology within the home. In addition, there is a further demand from consumers to make their lives easier and improve the time-efficiency of their laundry process.

Woodrow Scientific Limited (WSL) was established to address this need, inventing methods and apparatus that enable on demand cleaning of garments with massively reduced electricity and water consumption and without the fabric wear and tear of conventional washing machines.

The technical feasibility of WSLs LIRON technology has been proven with the worlds first laser-laundered shirts and informal consumer research has identified a market appetite for the unique technology and lifestyle benefits it offers.

The LIRON-2020 project presents an opportunity for WSL to further evaluate the market feasibility and identify the optimum route to commercialising the technology for this >1Billion global market.

Horizon 2020 funding will enable the company to further validate the performance benefits of its unique technology, strengthen and expand its IP portfolio and prepare the business strategy to leverage further investment / partnership and (potentially) Phase 2 project funding required to exploit the technology globally.";71429;50000;H2020-SMEINST-1-2014;SME-1;WOODROW SCIENTIFIC LIMITED;UK;;; 194973;654492;UACSURF;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Understanding atmospheric circulation from a surface perspective;1/04/2015;31/03/2017;;"Circulation changes are at the heart of changes in both regional precipitation and temperature and extreme events ranging from heavy precipitation to heat waves or cold spells. Understanding and modelling circulation changes in a warming climate therefore constitutes an emerging challenge for climate science. General circulation models still struggle to represent important features of the large-scale circulation in the present-day climate, which undermines confidence in future projections.
The present project is to combine a small-scale process-level with a large-scale dynamical perspective to investigate how drag processes at the Earth's surface associated with boundary-layer turbulence, orography and gravity waves affect large-scale circulation. Our aim is to develop a climatological view of the distribution and variability of individual components of surface drag as represented in general circulation models and to understand which processes or model parametrisations are responsible for current model biases especially in the representation of mid-latitude storm tracks.";195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF READING;UK;;; 194772;652200;EeHPC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Energy efficient High Performance Computing;1/11/2014;30/04/2015;;"Qarnot computing aims to develop a flexible High Performance Computing grid able to reuse the heat emitted by calculation units for the heating purposes of houses and business premises.

Regularly, huge data centers are opened for storage or calculation of numerical data. Needs, including calculation power, are becoming increasingly important, which explains the creation and implementation of more and more of these data centers. However, the past few years have shown that these clusters are particularly energy-consuming not only because of the calculations but also because of the cooling systems.

The idea is to sale processing power on the cloud. The calculations are smartly distributed to a remote computing grid. The grid is composed of calculation units that are actually electric heaters. The heat is produced by the processors that perform the computing.

Qarnot computing sales cloud HPC on one end, and refunds the electricity used by electric heaters on the other end. This solution allows Qarnot to build progressively a scalable computing grid avoiding the massive investments of a data center. Furthermore, there is no need to cool the infrastructure as the heat is directly used for heating purposes. Seasonality has already been taken into account by using CPU low power mode, install calculation units in strategic hosts such as schools that are closed during summer. In addition, computing power demand is seasonal, there is less jobs to perform during summer. Qarnot computing grid will be able to guarantee all year long a certain capacity, the extra power will be offered for free to universities and will be used as an adjustment variable (to meet the needs for calculation and the needs for heat).

Qarnot can therefore propose a very energy efficient cloud HPC for reasonable prices. This is one key to address the HPC market which already represents billions of euros. Qarnot will be able to propose greener cloud HPC for lower prices than the competitors.";71429;50000;H2020-SMEINST-1-2014;SME-1;QARNOT COMPUTING;FR;;; 194599;649689;SUNShINE;SIGNED;H2020-EU.3.3.7.;EE-20-2014;H2020;Save your bUildiNg by SavINg Energy towards 202020m2 of deeply renovated multifamily residential buildings;1/03/2015;28/02/2018;;"Deep renovation the idea of capturing the full economic energy efficiency potential of existing buildings with focus on building envelopes leads to remarkable energy savings. As nearly all of Latvias stock of multifamily residential buildings continues to rapidly deteriorate due to harsh weather conditions and lack of proper maintenance, the idea is attractive.
Realizing this potential requires designing, financing and implementing complex energy efficiency investments, but today nearly all apartments in Latvia are privately owned. Practice shows that individual owners are inadequately organized to manage their collective property. Combined with a lack of awareness and technical knowledge, limited availability of funding, high risk perception and reluctance for debt financing, the barriers overwhelm most people.
A concept that addresses these constraints is Energy Performance Contracting (EPC). A key feature of EPC is that the provider, an energy service company (ESCO), guarantees energy savings.
SUNShINE supports public and private ESCO's and leads to an innovative investment scheme with a pipeline of projects worth 30m, guaranteed savings over 26GWh/year, and 202020m2 of deeply renovated buildings. A major objective is to demonstrate the financial viability of deep renovation via suitable financial engineering of public funds and private capitals.
The proposed approach is simple, yet very innovative: most ESCOs have limited balance sheet capacity and are not able to support much long term debt. So re-financing is usually achieved by selling future cash flows (receivables) by a forfaiting transaction. After this transaction the ESCO continues to guarantee energy savings for the entire EPC term (15-20 years). Unfortunately, in emerging EPC markets like Latvia, there are not enough track records, so banks are not yet ready to offer these services to ESCOs. The project delivers the same service by establishing a special purpose fund for EPC.";1555991,25;1555991,25;H2020-EE-2014-4-PDA;CSA;RIGAS TEHNISKA UNIVERSITATE;LV;"ECO.NRG SIA;RENESCO SIA;EKODOMA;SIA SALASPILS SILTUMS;EKU SAGLABASANAS UN ENERGOTAUPIBAS BIROJS;FUNDING FOR FUTURE BV";"LV;NL"; 194682;651009;Smartick Games;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Smartick games. Augmented math learning.;1/11/2014;28/02/2015;;"This project is about perfecting Smartick, a leading online math training method, to introduce into the product a major new feature, so we can help millions of kids, mainly in Europe and Latin America, to improve their math and cognitive skills for learning.
As shown by international studies such as PISA and TIMSS, math skills are in short supply and are very much needed to power the high-skilled jobs required by todays society. Those jobs are needed if we want Europe to be competitive in a digital world currently dominated by the US, with some countries in Asia moving rapidly, with millions of highly skilled graduates coming out their universities every year.
To achieve it, we will integrate cognitive training with Smartick math, which will move Smartick strategic positioning into a non-occupied market space. With this unique product and the EC support, we can boost our growth to reach over 500.000 clients and generate over 100M in revenues in a period of 4 years, and fulfil our potential as one of Europes gazelle companies.
With this project we want to:
- Phase I: measure the potential, analyze the competitive landscape and design marketing and commercial strategies for the different target markets and languages,
- Phase I and mostly phase II: Scientifically challenge our vision with the help of two renowned research groups at the University of Granada and scale up internationalization strategy.
We honestly believe that, bringing together our technical capabilities, data and existing access to thousands of children, with the know-how, experience, scientific grounding and outreach capacity of two well-respected research groups, we will be able to further improve Smartick and build a learning and cognitive training platform second to none in the world.
With this project, at the end of the day, we want to help students in Europe improve their math skills to be better prepared for the technically qualified careers which Europe increasingly need.";71429;50000;H2020-SMEINST-1-2014;SME-1;SISTEMAS VIRTUALES DE APRENDIZAJE, S.L.;ES;;; 194790;652476;TORUS PROJECT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;HIGH PERFORMANCE COMMUNICATIONS FOR FINANCIAL SERVICES AND BIG DATA;1/11/2014;30/04/2015;;"The objective of this proposal is to receive funding and support for commercializing a set of disruptive high-speed communication protocols (IPR protected by patent and trade secret) which bypass the legacy and inefficient TCP/IP, the Internet protocol, designed 40 years ago. The technology is the result of \10 year R&D at University of A Corunna and the successful outcome of a Proof-of-Concept project (2011-2014) funded by Fundacion Barrie (0.5 M investment), which led to incorporate TORUS in April 2013 to further develop, commercialize and support the technology.
TORUS has 3 products in the market (Java Fast Sockets, Universal Fast Sockets and FastMPJ) which are up to 40 times faster than TCP/IP. These products reduce significantly the time-to-results of critical software, providing significant competitive advantages in multiple sectors, particularly for financial services, real time Big Data analytics (with multiple applications, such as real time online advertising), biotech (supporting DNA processing in hours, instead of weeks), and defense/space (FastMPJ has reduced up to 94% the time to distribute satellite images of ESAs Gaia Mission). Additionally, the technology reduces costs (power and software licensing) significantly, as fewer servers with TORUS outperform a higher number of servers interconnected via TCP/IP.
The specific objectives of the feasibility study are: (1) acquire knowledge on how clients perceive TORUS value; (2) develop an effective go-to-market strategy; and (3) partner with key industry players (TORUS is in talks with two multibillion companies listed in NASDAQ). TORUS is about to rise 1M for funding next commercialization steps during 2014-2015. A new round of 4M is expected in 18-24 months, to definitively enter in the growth stage. SME Instrument would definitively fuel this high-tech disruptive European project. Our mission is to make servers respond faster than the speed of thought, no more waiting for computers!";71429;50000;H2020-SMEINST-1-2014;SME-1;TORUS SOFTWARE SOLUTIONS S.L.;ES;;; 194865;653434;MitSyn;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Alpha-synuclein and mitochondrial dysfunction: key links between Gauchers disease and Parkinsons?;13/04/2015;12/04/2017;;"Recent studies have highlighted a strong genetic association between Parkinsons disease (PD) and Gauchers disease (GD), a lysosomal storage disorder that causes severe neurodegeneration in children and shares some pathophysiological features of PD. GD results from mutations that reduce activity of the enzyme glucocerebrosidase (GCase), causing impaired lysosomal function. It was recently shown that GCase mutations cause several defects associated with impaired cellular quality control - impaired autophagy, mitochondrial dysfunction and accumulation of oligomeric alpha-synuclein, a protein strongly involved in sporadic and genetic PD forms. In fact, alpha-synuclein aggregates are the main constituent of Lewy Bodies, characteristic proteins inclusions found in parkinsonian brains. While PD shows similar features and involves defects in the same pathways, it remains unclear how these diverse findings relate to each other.
In the present study we propose to identify the specific interactions between intracellular signaling pathways, cellular quality control pathways and alpha-synuclein oligomerization in an attempt to generate a unifying hypothesis that brings together known features of GD and PD pathophysiology. We will use primary neuronal cultures from gba knockout mice and inducible pluripotent stem cells derived from the GD mouse model and from patients, in which alpha-synuclein will be overexpressed or silenced. Mitochondrial (dys)function, impaired clearance mechanisms and alpha-synuclein oligomerization will be quantitatively characterized in these models by means of an array of biochemical, biophysical and advanced imaging techniques. The results of the work will give us further insights into PD molecular mechanisms and may provide new therapeutic targets.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITY COLLEGE LONDON;UK;;; 194774;652237;INCH;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;INteractive CHarging;1/09/2014;28/02/2015;;"The INteractive Charging (INCH) project aims to commercialise a price-performance optimised smart AC charging station for plug-in electric vehicles (PEVs). It will be designed primarily for home use and use in semi-private areas where several PEVs are charging at the same time. The device will support smart charging of PEVs by offering advanced features not yet available on the market: remote interactive charging power management, real-time communication with external actors, advanced power management, different connectivity options, clustering of charging stations in the same area, precise metering of energy consumption within the charging station and support for latest charging protocols. The INCH project will present an enabling technology for the integration of PEV charging into the European smart grids and for the provision of new services in electromobility.
There are two main categories of users that will benefit from INCH: end users who use the PEV charging station and other electromobility actors (service providers, PEV supply equipment operators, DSOs, energy providers, VPP operators) who can offer new services to these end users. End users will benefit from easily charging a PEV on the existing installation without worrying about potential outages, thanks to built-in flexible power management. Other electromobility stakeholders will be able to offer new added value services based on controllability and new data coming from smart charging stations.
The proposed feasibility assessment will produce a study which will assess the technical and commercial feasibility of INCH by identifying relevant use cases, analysing user needs, defining the corresponding new functionalities, and researching the HW and SW required for the support of these new functionalities. Economical feasibility of the project will be assessed within the initial business plan, which will include evaluation of project costs and a detailed time-plan for the potential Phase II.";71429;50000;H2020-SMEINST-1-2014;SME-1;ETREL SVETOVANJE IN DRUGE STORITVE DOO;SI;;; 194726;651452;GALNIMBUS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Disruptive cloud-based irrigation controller to optimize water use efficiency in agriculture;1/10/2014;31/01/2015;;"The objective of GALNIMBUS is to improve irrigation-water use efficiency up to 30% by developing a cloud-based irrigation controller able to perfectly match irrigation and fertigation doses to crop needs.
The system in order to perform detailed real-time forecasts for crop water requirements
-Defines irrigation needs based on crop specific data bases
-Analyses real time data from the field (soil moisture, solar radiation, pH, plant stress, etc ) to evaluate crop status.
-Checks online weather forecasts to readjust irrigation doses
-Satellite images
Thanks to GALNIMBUS irrigation tasks are fully automatized, and the grower can monitor the crop or activate irrigation valves remotely anywhere at anytime.";71429;50000;H2020-SMEINST-1-2014;SME-1;GALCON BAKARIM AGRICULTURAL COOPERATIVE SOCIETY LTD;IL;;; 194735;651556;SO2SAFE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Enzymatic SO2 biosensor for rapid food safety monitoring;1/10/2014;28/02/2015;;"Overall objective of the SO2SAFE Project is to develop a new miniaturized ready to use biosensor based on disposable screen printed electrodes (SPE) which will allow a highly sensitive, selective, fast, low-cost and user friendly method for determination of sulphites in crustaceans, since this is a type of food where the sulphite is commonly used. The novel solution will have a direct impact not only in the food industry economy, but also in the society due to the direct impact the sulphite has in health. In order to achieve this main objective, the following specific objectives will be targeted:
Design and fabrication of disposable and high reproducible SPE that can be mass manufactured by microfabrication technologies.
Biofunctionalization of SPE with a specific enzyme for sulphites detection.
Development of a fast, simple and user-friendly miniaturized measure device for SPE lecture.
Development of a reproducible large-scale fabrication methodology (scale-up) that allows the commercialization of the ready to use pre-calibrated solution in order to simplify analysis by eliminating pre-analytical steps.
BIOLAN has already developed at the laboratory scale a simple, reliable and specific enzymatic biosensor for sulphite determination and has obtained relevant data that support the innovative project here proposed versus the other methods currently available. Based on these data, BIOLAN expects to address the above listed objectives and become ready to give answer to the expected demand first in the specific market segment of crustaceans and later to open new market opportunities in other sectors such as wine, juices, etc.
Through the Phase 1, BIOLAN will be able to better study the feasibility of the here proposed innovation project and design in the more accurate way the breakthrough innovation activities to be developed during Phase 2, opening new market opportunities that will be reflected in the company growth and internationalisation.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOLAN MICROBIOSENSORES S.L.;ES;;; 194668;650513;SURVEIRON;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.7.";DRS-17-2014-1;H2020;SURVEIRON: Advanced surveillance system for the protection of urban soft targets and urban critical infrastructures;1/09/2014;28/02/2015;;"SURVEIRON is an innovative solution for the protection of urban environments and critical infrastructures that provides those in charge of public and private security with an intelligent surveillance service, allowing them to take optimal security decisions. SURVEIRON constitutes a powerful tool not only for the prevention of disasters but also for their management. In both cases, SURVEIRON makes it possible to make the most secure decisions possible. Thanks to this system, those in charge of coordinating security will be able to minimise the risks currently taken due to a scarcity of available information, which in general is provided solely by security cameras (where these exist or control the area to be protected) and telephone calls. Such gaps in the information available cause serious security problems.

The project is based in a set of intelligent robots embedded inside a fleet of unmanned aerial vehicles (UAVs). This fleet is deployed in fixed and mobile locations and supervised from an emergency command center. Once an alarm is notified, the system sends one or more UAVs to the emergency area avoiding any obstacle in their way. Once there, SURVEIRON starts scanning the environment with different detection technologies. All the data obtained is sent to the control center and represented in a 3D environment for an easy interpretation and evaluation of the current events in real time. As an example, in a fire emergency, SURVEIRON will provide the actual status of the infrastructure affected and the total amount of energy generated by the fire. With this information, the system is capable of measuring the volume of fire extinguisher needed to suffocate the fire and the amount of personnel that have to be mobilized to participate in the fire-fighting tasks. It will also scan for people in the surrounding area that might need evacuation or assistance. All this information will be displayed in the command center.";71429;50000;H2020-SMEINST-1-2014;SME-1;AEORUM ESPANA S.L.;ES;;; 194769;652138;Briareo;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Implementation of a vertical axis micro-wind turbine capable of working at high efficiency even at a low wind speed.;1/10/2014;31/01/2015;;"Briareo is an innovative micro-wind turbine intended at offering users a higher efficiency of power generation with low speed winds, thereby increasing the penetration rate of this renewable energy technology throughout the European Union and worldwide. Current commercial micro-turbines operate on average only 20% of the time being unable to work at wind speeds less than 4m/s. This result has given micro-wind turbines an inefficient and undesirable reputation, and they are now scarcely recommended by suppliers as they cannot guarantee their payback time.

The patented Briareo polymeric blade has been designed by applying high quality aerodynamic principles to operate in both lift and drag modes according to the specific wind, being especially performing in winds lower than 4m/s. The SME proponents have eventually developed their own turbine which in tests has exhibited a rotational capacity 4x that of current turbines. The Briareo micro-wind turbine is based on the Ikea concept: it can be purchased of the shelf, easily self-assembled and installed without needs for certification, not imposing greatly on its residency (smaller than 100cmx150cm) or producing much noise. The high manufacturability of Briareo allows the use of the low cost rotational moulding industrial process.

The technology has reached a TRL of 6 and Phase 1 project aims at establishing a robust industrialization and operational plan, at identifying all stakeholders in the value chain securing appropriate suppliers, sale channels and strategic partnerships, at contacting potential early adopters communities that can ensure a quick market test and at strengthening the business model with an in-depth market analysis, sound marketing strategy and reliable financial projections.
Briareo project is proposed by 2 Italian SMEs, Arken and Gymnotus, who have strictly cooperated on the design, prototype development and test since the beginning, equally sharing the IP ownership.";71429;50000;H2020-SMEINST-1-2014;SME-1;ARKEN SPA;IT;GYMNOTUS SAS DI FOCANTI VALERIO & PROFILI MARCO;IT; 194757;651921;Elastomer Recycling;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;World`s first innovative method for recycling of elastomers and plastics from industrial waste;1/11/2014;30/04/2015;;"World`s first innovative method for recycling of elastomers and plastics from industrial waste

The demand of plastics is increasing constantly. More than 300 million tons of plastic are consumed each year. This leads to 30 million tons of plastic waste per year. The HLW TEC GmbH can handle this waste.
The HLW TEC GmbH will provide environmental friendly solution for industrial thermoplastic and elastomeric waste, as well as an efficient access to high quality raw material.
Our goal is to increase the ratio of significant feedstock recycling by utilizing industrial plastic and elastomer waste.
Nowadays there are no conclusive solutions for the recovered substance cycle for plastic material which can ensure the same quality as the primary synthetic materials.
The HLW method allows to preserve industrial waste, even elastomers, in the raw material cycle. Processed materials are brought into the original mixture without any loss of characteristics.
Since the demand for plastic materials increased by 9.5% every year since 1950 Europe faces austerity of feedstock. In addition to that one of EUs goals to reduce waste dumping up to 0% which seems to be difficult regarding the nowadays waste salvage in Europe. The HLW-TEC method can serve as a solution.
Main goal of phase one is to collect all relevant information for a reliable feasibility study. Phase two is to bring our innovative method to every plastic processing company across the globe.";71429;50000;H2020-SMEINST-1-2014;SME-1;HLW TEC GMBH;DE;;; 194631;649883;URBAN LEARNING;SIGNED;H2020-EU.3.3.7.;EE-07-2014;H2020;Integrative energy planning of urban areas: collective learning for improved governance;1/03/2015;30/11/2017;;"URBAN LEARNING gathers capitals and other large cities across Europe facing the common challenge of considerable population growth while being committed to significantly reduce fossil energy consumption and CO2 emissions. E.g. Stockholm grew by more than 12.000 people / a (1.5%); in the next 10 years Vienna has to build for 200.000 new people. Efficient and effective planning processes will be crucial for climbing this mountain.
Vienna, Berlin, Paris, Stockholm, Amsterdam/Zaanstad, Warsaw and Zagreb aim to enhance the capacity of their local authorities on integrative urban energy planning, as response to new challenges from EU EPBD and RES directives as well as to changes of technologies and market conditions and the pressure to provide sufficient, affordable homes. The focus is put on the governance processes related to the (re-)development of concrete sites. While some cities already started ambitious urban development projects, the institutionalisation of these experiences is missing - despite awareness and willingness, due to lack of knowledge, lack of time and the need for collaboration across departments, which is not a common practice in many administrations in Europe. External stimulus is needed to overcome these barriers, and to address these issues collectively with external key stakeholders, such as DNOs and energy suppliers, and across cities.
Focus will be on multi-disciplinary learning concentrating on innovative technological solutions, instruments and tools as well as on innovative governance elements - and to capitalise this learning to institutionalise integrative urban energy planning.
Improving the governance processes is expected to have significant energy impacts on homes and workplaces to be built and refurbished for over 3 million more people in the participating cities in the next 20 years: more than 1.700 GWh/a of energy savings and over 2.000 GWh/a renewable energy produced. Special emphasis is put on knowledge transfer to 150 more cities.";1850062,5;1850062,5;H2020-EE-2014-3-MarketUptake;CSA;TINA VIENNA GMBH;AT;"STOCKHOLMS STAD;GRAD ZAGREB;BERLINER ENERGIEAGENTUR GESELLSCHAFT MIT BESCHRANKTER HAFTUNG;GEMEENTE AMSTERDAM;AGENCE PARISIENNE DU CLIMAT ASSOCIATION;ENERGETSKI INSTITUT HRVOJE POZAR;MIASTO STOLECZNE WARSZAWA;MAGISTRAT DER STADT WIEN;VILLE DE PARIS;GEMEENTE ZAANSTAD";"SE;HR;DE;NL;FR;PL;AT"; 194850;653337;NEXES;SIGNED;H2020-EU.3.7.;DRS-19-2014;H2020;NEXt generation Emergency Services;1/05/2015;30/04/2018;;"The NEXES Research and Innovation Action aims to research, test and validate the promising integration of IP-based communication technologies and interoperability into the next generation emergency services, so that they attain increased effectiveness and performance.
Empowered by smartphones with cameras, messaging and internet-based applications connecting to social media, citizens expect emergency services to use the same technologies. However, this is not the case.
NEXES innovates the approach to the dynamics between emergency services and citizens, allowing (i) the use of total conversation capabilities in emergencies, including social media, to the benefit of citizens, including those with disability or special needs (ii) the exploitation of improved location information to rapidly and effectively identify and locate the caller and the incident site and (iii) the leverage of Internet-enabled connectivity to enhance interoperability and shared awareness among emergency services, to the benefit of a more secure society.
The NEXES Consortium gathers world-class European entities, well experienced in the research and development of innovative solutions for communications and emergency products and solutions. The NEXES Team presents extensive background knowledge and in-house solutions to adapt, test and validate in NEXESs open Testing Regime and Validation Framework, ensuring solid results are achieved to produce relevant Recommendations and contributions to Europes standardisation effort on emergency services. To leverage related dissemination and market exploitation activities, the NEXES System, Apps and its operational benefits are demonstrated in three realistic pilots to end-users and stakeholders. In fact, end-users involvement, directly ensured by NEXES Partners and indirectly by invited Advisors, is a key contributor to guarantee NEXESs operational validity as a reference implementation system for next generation emergency services.";5761083,75;5760836;H2020-DRS-2014;RIA;RINICOM LIMITED;UK;"European Union of the Deaf;Azienda Regionale Emergenza Urgenza;AIMTECH CONSULTING LIMITED;ORANGE ROMANIA SA;INSTA DEFSEC OY;OMNITOR AB;Prefecture de Police;UNIVERZA V LJUBLJANI;MINISTERO DELL'INTERNO;DEVERYWARE;POLICE AND CRIME COMMISSIONER FOR WEST YORKSHIRE;POLIISIAMMATTIKORKEAKOULU;TEAMNET INTERNATIONAL SA;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS;TELEKOM SLOVENIJE DD;Ambulance and Emergency Physicians Association";"BE;IT;UK;RO;FI;SE;FR;SI;EL;TR"; 194653;650242;GEO PAC RET;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;GEO PAC RET an Innovative Heat Pump for Geothermal district heating in Europe;1/10/2014;31/03/2015;;"While Europe undertakes an energy and ecological transition toward cleaner way of producing electricity, transportation and heating remains highly dependent of fossil fuels. We believe that heating systems in Europe could be rapidly transformed into low carbon systems using geothermal sources coupled with efficient heat pump, and that this transformation can be done with great benefit, a reduction of the cost of energy and the use of a well-known almost unlimited resource: the geothermal energy. Technologies are available, the potential is big, regulatory barriers are low, but new players are required to make things change on the market at a greater scale.

Since Fall 2012, Enertime is developing PACRET, a new concept of industrial high temperature heat pump (above 80C) with a high performance proprietary compressor. A conceptual study has been started in 2013, involving university of Liege for support in cycle definition and EPFL in Lausanne for the compressor aero dynamical design.

Enertime wants to perform a feasibility study /market study for its innovative flexible heat pump PACRET using geothermal energy as primary heat sources in Europe. This study will be conducted with the support of GZB, the International Geothermal Centre based in Bochum, Germany as subcontractor

Ahead is the opportunity to transform centralized carbon intensive district heating networks into low carbon distributed District Heating powered by geothermal energy, possibly using also the Heat pump to absorb excess electricity production using the thermal inertia of the District Heating network.";71429;50000;H2020-SMEINST-1-2014;SME-1;ENERTIME SA;FR;;; 194822;652925;MIGRANTCHRISTIANITY;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Migration, religion and work in comparative perspective. Evangelical ethnic churches in Southern Europe;1/09/2015;31/08/2017;;How do Evangelical migrants use religion and church-related networks to seek employment, pursue social mobility, construct respectability and resist racism? How do Evangelical churches become brokers of socio-economic integration of their members thus stakeholders in immigration countries? These are the main questions that this project seeks to answer. MIGRANTCHRISTIANITY investigates how migrant men and women from Sub-Saharan Africa and Latin America make use of a minority religion in negotiating their social and economic integration in Europe. The project focuses on Ghanaian and Ecuadorian migrants in Italy and Spain. I investigate how migrants develop strategies of integration through the Evangelical churches and how such strategies are shaped by ethnicity, class, gender and age. I also look at how Evangelical churches act as brokers of integration, in relation to employment but also with reference to a wider social positioning of the migrant as a minority Christian. In doing so, the research contributes to our understanding of the role of religion in migrants integration or marginalisation and of how migration is reconfiguring the Italian and Spanish societies through the production of new understandings of Christianity: these churches challenge the Catholic majority religion as well as dominant views of migrant religion as Islam only. The MIGRANTCHRISTIANITY project brings together two hitherto separate strands of research: that on migrant labour and ethnicity on the one hand, and that on migration and religion, more specifically on migration-driven Evangelical churches, on the other.;160477,2;160477,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;EUROPEAN UNIVERSITY INSTITUTE;IT;;; 194960;654261;ToEfDeCo;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Towards Guaranteeing the Right to Effective Assistance of Defence Counsel in Member States in Trans-border Criminal Cases;1/01/2016;31/12/2017;;"The right to effective assistance of defence counsel (READC) is one of the fundamental features of fair trial. In the context of open borders and increasing number of trans-border criminal cases it is important that all EU Member States (MS) guarantee the READC to suspects and requested persons in European arrest warrant cases at least on a minimum level. The Strasbourg system is no designed to achieve this goal, so the EU has taken the initiative via the Directive 2013/48/EU on the right of access to a lawyer in criminal proceedings etc. (22 Oct 2013). Considering the imminent transposition date of 27 Nov 2016, this project aims at determining how the MS are progressing in implementing the Directive. As the Directive not only guarantees the READC, but also requires that in case of breach of the READC, the MS have to ensure effective remedies, the final goal of the project is to propose remedies for trans-border cases that could be common to all MS. The research activities will be performed in the international environment of the Maastricht University, a centre of expertise on research on the READC in Europe, and will consist of two parts.
The first part of the research will be empirical; competent representatives of all MS will be interviewed about how the MS have implemented or are planning to implement the Directive, including any difficulties they are encountering. In addition, the representatives will be queried about the remedies provided currently or prospectively.
The second part of the research will be normative; information received from MS will be compared to legislation of the EU, the jurisprudence of the European Court of Human Rights, the European Court of Justice, international tribunals, the International Criminal Court, and the Supreme Court of the US as well as the theoretical approach to the READC in the US. As a result common remedies for the violation of the READC in the EU with a special focus on trans-border criminal cases will be proposed.";177598,8;177598,8;H2020-MSCA-IF-2014;MSCA-IF-EF-CAR;UNIVERSITEIT MAASTRICHT;NL;;; 194686;650716;OPTIFUEL;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;A reliable and transparent solid biofuels online quality control system;1/10/2014;31/01/2015;;"Ultimate target is to develop a reliable and transparent online solid biofuels quality control system and concept that enables for the biomass power plants:
- Reduces energy production costs 1-5 %
- Increases plants efficiency 0,1 - 1 %
- Reduces GHG emissions by 5-10 % in the whole production chain.
- Reduces the need of sampling and laboratory analysis by 70-90 %
- Enables up to 1 million euros savings per power plant in investment costs compared to current automatic sampling systems
- Payback time less than 2 years
In the EU level the exploiting of the system decreases greenhouse gas emissions annually by up to 500 000 tons, increases renewable energy production and increases EUs self-sufficiency in biofuels. The size of the market is estimated to be over one billion euros.

In bioenergy production the solid fuel quality and especially moisture content and share of foreign matter are the key parameters. The water content of the fuel is a parameter used in the regulations of some manufacturers to manage the settings of a biomass boiler. But it is also essential for verifying energy content of the fuel delivered to the power plant which is base for fuel pricing. Solid biofuels often contains foreign matter such as stones, sand, soil and also metals that lowers energy content and increases operation and maintenance costs in the power plant. High moisture content and amount of foreign matter in biofuels increases operation and maintenance (O&M) costs for the whole production chain.
Current practise of biofuel quality control is based mainly on manual sampling and laboratory analysis method which is uncertain and requires a lot of manual work. Inrays technology that enables solid biofuels online quality data that can be used in optimizing power plants processes.

Specific objectives for this feasibility study are: End-user survey, Partner search, IPR survey and Elaborated Business plan development.";71429;50000;H2020-SMEINST-1-2014;SME-1;INRAY OY LTD;FI;;; 194584;649456;ENLIGHTEN;SIGNED;H2020-EU.3.6.;EURO-4-2014;H2020;European Legitimacy in Governing through Hard Times: the role of European Networks;1/04/2015;31/03/2018;;ENLIGHTEN responds to the first part of the EURO-4 call on The future of European integration - 'More Europe less Europe?' by bringing together an interdisciplinary next generation research team that integrates insights from Comparative Political Economy, European Studies, International Political Economy, and Sociology. ENLIGHTEN answers the call by focusing on how European modes of governance respond to fast-burning and slow-burning crises. These types of crises differ in how they affect the legitimacy of European input, output, and throughput processes in established and emergent modes of governance. In fast-burning crises interests are quickly formed and ideational and resource battles ensue over how to coordinate policy ideas, what institutions should be engaged, and communicating these changes to the public. Networks in fast crises are composed of defined groups seeking to protect or carve out their interests. In slow-burning crises interests are less obvious and the key task is often how to define the issues involved and who should address the problem. Here networks are commonly composed of experts who battle over how issues should be defined, as well as the boundaries on how coordinative and communicative discourses are articulated. Both fast- and slow-burning crises must be addressed by European modes of governance, with serious implications for the legitimacy and efficiency of the European project. Both raise political, social, and economic sensitivities that are transforming democratic politics in Europe. ENLIGHTEN addresses these themes through a series of linked cases that speak directly to the legitimacy and efficiency of European modes of governance.;2484111,25;2484111;H2020-EURO-SOCIETY-2014;RIA;COPENHAGEN BUSINESS SCHOOL;DK;"COMITE EUROPEEN DE COORDINATION DE L'HABITAT SOCIAL AISBL;UNIVERSITE LIBRE DE BRUXELLES;FINANCE WATCH AISBL;TAX JUSTICE NETWORK LIMITED;CONFEDERATION EUROPEENNE DES SYNDICATS ADF;UNIVERSITEIT VAN AMSTERDAM;KOZEP-EUROPAI EGYETEM";"BE;UK;NL;HU"; 194638;649982;SEI Metrics;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Developing Sustainable Energy Investment (SEI) metrics, benchmarks, and assessment tools for the financial sector;1/03/2015;28/02/2018;;"The challenge we aim to address in this project is the lack of investment in sustainable energy and energy-efficient assets from public and private financial institutions. The core approach of the project is to define what a sustainable asset and a sustainable investment portfolio is, and to develop an assessment framework in order to allow financial institution to measure their performance and set progress targets vis--vis energy-climate goals. This approach builds on the research done over the past few years by various organizations. The project will develop an assessment framework allowing investors to measure and manage their climate performance (i.e. their exposure to sustainable energy and energy efficiency investments). This framework will include a translation of climate-energy investment roadmaps into targets for the finance sector, an assessment methodology for assets (e.g. equity shares in companies), and an assessment methodology for investment portfolios. The project will embed the framework into the standard toolbox used by investors to inform their asset allocation strategy, which will include an upgrade of databases used by investors; the integration of Sustainable Energy Investment performance metrics into portfolio optimisation tools, in order to allow investors to optimize climate and financial performance at the same time; and SEI benchmark indices in order to allow asset owners to integrate climate goals in the mandates of asset managers. The project will lead to several publications and a series of workshops with practitioners on Sustainable Energy Investment Metrics including a study on the risk-adjusted returns of SEI strategies; a study dealing with the implications of SEI metrics for financial policy-makers; and various workshops across Europe involving experts and financial institutions, to discuss methodological options, train practitioners on the assessment frameworks, and get feedbacks from road tests.";2511253,75;2362378,75;H2020-EE-2014-3-MarketUptake;CSA;ASSOCIATION 2 INVESTING INITIATIVE;FR;"WWF EUROPEAN POLICY PROGRAMME AISBL;FRANKFURT SCHOOL OF FINANCE & MANAGEMENT GEMEINNUTZIGE GMBH;WWF DEUTSCHLAND;UNIVERSITAET ZUERICH;CLIMATE BONDS INITIATIVE;KEPLER CAPITAL MARKETS SA;SOCIETE DE MATHEMATIQUES APPLIQUEES ET DE SCIENCES HUMAINES;CDP WORLDWIDE (EUROPE) GEMEINNUTZIGE GMBH";"BE;DE;CH;UK;FR"; 194711;651158;ENABLE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Establishment of a Neutrophil elastase Activity home test for the Better management and treatment of Lung Exacerbations;1/10/2014;31/03/2015;;"Chronic obstructive airways disease (COPD) is a leading cause of death of increasing prevalence worldwide and is characterised by progressive airflow reduction, breathing difficulties and irreversible lung damage. Management of COPD varies extensively, with patients not receiving proactive disease management at greater risk of poorer outcomes. Routine measurement of an active protease (enzyme) biomarker called neutrophil elastase (NE) will empower clinicians and patients to adopt proactive approaches to disease management and treatment, reducing exacerbations and emergency hospital admissions.

Our goal is therefore to develop a novel, simple to use Point-of-Care (PoC) test that will improve patient outcome and reduce the clinical, societal and economic burdens associated with chronic respiratory disease (CRD). The activity of NE (NEa) in the airways is known to correlate with the severity of several CRDs such as COPD, cystic fibrosis (CF) and bronchiectasis, and importantly is highly predictive of infection and an early marker of exacerbation. Our novel device, NEATstikTM (Neutrophil Elastase Airways Test), will enable the rapid measurement of NEa at PoC and has been designed for home use (patient self-management) in mind, with a view to remote monitoring. It is expected that this test will help to improve patient management and outcome, with the ultimate goal of reducing the individual, European and global burden of COPD.

This phase 1 proposal is to provide a feasibility assessment which will maximise the potential for success the clinical validation of NEATstikTM, a PoC device that will enable the proactive management of chronic respiratory diseases such as COPD.";71429;50000;H2020-SMEINST-1-2014;SME-1;PROAXSIS LTD;UK;;; 194742;651643;BAG-FS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Biopolus Aero Green - Feasibility Study;1/09/2014;30/11/2014;;"The objective of the innovation project is to bring to market a high-yield, highly automated aeroponic plant cultivation system suitable for resource efficient, high quality vegetable and fruit production in a limited physical footprint. This core technology and the associated supporting services are expected to be enablers of the widespread appearance of urban farms.
The system lessens agricultural land use. Moving production closer to the place of consumption enables reduction in transportation needs, emissions and food waste production. The aeroponic technology produces very high yields while using the fraction of water. The system has the following main economic benefits for the users:
year-round crop production
no weather-related crop failures
no use of pesticides, herbicides
use of 75-95 % less water than the same productive technologies
greatly reduced food-miles
higher food security and safety
high yield in crop production
User needs met by the system: demand for products with trustworthy proof of socially and environmentally responsible business practices, demand for chemical-free food products.
Targeted users are those SMEs and farmers who produce indoor, and those restaurants and supermarkets where day-to-day fresh fruits and vegetables are important.
Economic benefits and ecological impact are the main appeals of the technology. The feasibility assessments goal is to quantify these advantages which are major milestones toward successful commercialization.
Phase 2 plans are a first demonstration facility and building out full capacity of manufacturing.
European dimension: Flagship sustainable biological technologies like Biopolus Aero Green system can help the EU secure its leading position to address ecological challenges and achieve economic growth.
Global dimension: BAG system enables food production in urbanized areas and lessens dependence on outside sources and imported foods.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOPOLUS TECHNOLOGIAK ZRT;HU;;; 194696;650796;SignSigma;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Launching the next generation of mobile and multi-platform signature system based on biometric parameters;1/09/2014;30/11/2014;;"The SignSigma technology, developed by the SME Sigma Technologies, allows verifying the identity of a person from the dynamic parameters of their biometric signature with an extremely very low error ratio for first time merely using a common tablet or smartphone. The technology is not based on the image of the signature but on its dynamic biometric parameters (pressure, velocity, acceleration, etc.). This technology has been recognised as the best technology in the First International Signature Verification Competition.

Smartphones, tablets and the growing access to mobility will accelerate identification needs, and ease its introduction through various applications like banking, the health sector, insurance, digital preservation, control access, etc. The range of applications is huge, as this disruptive technology creates new markets as it will permit to be identified at anytime, and anywhere.

We are almost done developing technology and we need the SME Instrument in order (i) to finalise the extensive trials we are undertaking on the different platforms (smartphones, tablets), (ii) to select and prioritize the most adequate application/s, (iii) to implement the final applications and integrate them with the specific enterprise content management systems, (iv) to undertake an intensive pilot tests of the product and the technology and (v) to assess the security of the whole system. In Phase 1, our specific objective is to prepare a clear Feasibility Study and Business Plan on how to reach and exploit this extraordinary technology properly in different scenarios, which might imply different business models, and different market strategies.

It is expected that a new European directive will be issued authorizing and giving much more legal power to biometric signatures as in the US. This technology will permit to reduce paperwork, reduce costs, save time in operations, and decrease fraud by bio-identity, consequently having a significant impact on the economy.";71429;50000;H2020-SMEINST-1-2014;SME-1;SIGMA TECHNOLOGIES S.L.;ES;;; 194671;650571;SMARTGEARBOX;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Development of a new gearbox without lubricants for low OM costs, higher efficiency, and oiless applications;1/11/2014;28/02/2015;;"Located in the Bologna region in Italy, our company, VARVEL, is specialized in manufacturing of speed reducers and variators for light industry applications, such as machinery, conveyors, feeding systems, photovoltaic devices or sliding doors and so on (metalworking, chemical, textile, farming, construction industries).
From its establishment in 1955, innovation has been guiding our company in every decision and business strategy, making us a strong and reliable partner in power transmission equipment on the international scene (Production: 300,000 units/Turnover: 31 million [2013]): from product research to increasing use of automation and robotics in manufacturing, from company management by formalized processes to logistics flow computerization. All our efforts focusing on the customers needs and satisfaction, in terms of product uses, costs and performance.
Listening to our customers feedback and concern on oil maintenance and leaking risks, we have been working on new oiless gearbox: by eliminating oil lubricants, we can decrease the operation and maintenance costs of our products by 50% and increase their efficiency by 10-15% while making them more environmental friendly. Besides, this new product will allow us to penetrate new markets such as food processing and medical, where the use of lubricants is prohibited. This project, called Smart GearBox, aims at integrating our developments on our worm-wheel gearboxes for commercialization, achieving a long-term profitability for both our customers and our company: increase of sales margin by 11% and sales by 42%, leading to an additional 6.3 million of turnover by 2020";71429;50000;H2020-SMEINST-1-2014;SME-1;VARVEL SPA;IT;;; 194720;651315;NIR-PERFECT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Non-contact Near Infra-Red insPEction and monitoRing For Evaluation of ComposiTes;1/11/2014;30/04/2015;;"Increasing automation and demands for quality in production (food, pharmaceuticals, non-metals such as polymers and composite components etc.) has resulted in visual and optical inspection by humans becoming impractical in certain situations. Therefore there have been a number of non-destructive techniques developed to inspect, monitor and detect impurities and defects within products in production lines. Existing inspection tools such as X-ray imaging have been used to inspect engineering materials and food products but are subject to health and safety issues as well as large equipment footprint and high cost resulting in unsuitability for many inspection situations.
Structural health monitoring (SHM) and damage detection techniques are also of great importance in the offshore, civil, mechanical and aeronautical engineering communities, both for safety reasons and because of the economic benefits that can result. The need to be able to detect damage in complex structures has led to the development of a vast range of non-destructive techniques (NDT), of which many are based upon structural vibration analysis. However, the majority of NDT systems for SHM are slow, costly and require long periods of downtime to complete. They also struggle to give structural information on near surface (<10 mm) layers.
We have developed an innovative and new form of NDT, based on Near Infrared (NIR) inline inspection and detection of defects, which has been validated for non-metallic engineering materials and is capable of providing a rapid, more informative and cost effective NDT solution for composite manufacturers and end users.
The NIR-PERFECT project will therefore develop a more robust business plan for this new NIR NDT inspection and monitoring system. This will then enable us to define end user specifications and allows us to align our engineering approaches to further optimise the system to meet future end user requirements.";71429;50000;H2020-SMEINST-1-2014;SME-1;INSPECTION TECHNOLOGIES LTD;UK;;; 194727;651475;SINTRAN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Safe and INtegrated thermal TRANsformation of humid organic waste resulting in green energy and valuable remainders;1/11/2014;30/04/2015;;"The objectives of the overall innovation project are the optimization and certification and EU-wide commercialization of a methodology to safely transforming humid organic waste (such as sewage sludge) into green energy (electricity) by combustion while extracting valuable materials from the remainder ash like phosphate. The technological feasibility has already been demonstrated; therefore the project outcome will be a system that is certified, marketable and clearly positive on cost-benefit side.
The waste in the scope of the SINTRAN project taints and environmental risk factor. Its humidity is high; therefore simple combustion is challenging and may be hazardous. The state-of-the-art handling methodology does not eliminate the risk of soil pollution (e.g. heavy metals may leak into the soil or water). SINTRAN projects proposed technology not only takes care of this risk, but also integrates green electricity generation and may act as a resource of valuable agricultural material, processing the remainder of the disposed waste, while increasing the employment potential in the waste recycling and energy sector around Europe.
The proposal is made for Horizon 2020 topic SIE-01-2014-1 Phase 1 Stimulating the innovation potential of SMEs for a low-carbon energy system. Measured data of the working prototype clearly indicates the solutions potential in low-carbon, green energy supply, addressing the challenge reducing energy consumption and carbon footprint by smart and sustainable use as well with the important added value of secure and safe disposal and recycling of hazardous waste such as extracting valuable materials from the remainder ash like phosphate.";71429;50000;H2020-SMEINST-1-2014;SME-1;BIOMORV LTD.;HU;;; 194681;651036;iBoard;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Large scale interactive multi-touch displays;1/11/2014;30/04/2015;;"There is currently an established worldwide market worth annually more than $2 billion for interactive whiteboards. These whiteboards are mainly used in schools and other educational establishments. The end-users expect that a new generation of interactive whiteboards will support multi-touch finger input, yet current touch sensing solutions, while adding thousands of dollars to the cost of a large display, are striving to meet the technical specification for multi-touch interfaces. Our technology will disrupt this existing market. Alterix has invented a novel, highly efficient and low-cost electronic solution for measuring touch inputs. By achieving a hundred-fold increase in the measurement speed compared to the touch interfaces commonly used in tablets and mobile phones, our technology scales easily to large displays with diagonal sizes up to 250cm and is compatible with interactive whiteboards and flat-panel TVs. To serve the educational market the cost of interactive transparent TV display overlays must be reduced by replacing the indium a critical raw material in short supply - which otherwise would be used to build the transparent sensor grid. To achieve this goal Alterix is transferring the inexpensive technology for making laminated ultrafine (nearly invisible) wires developed in the last decade for heating the windscreens of modern cars.

It is now of strategic importance for Alterix to study the feasibility of establishing a functional supply chain, preferably within Germany and Portugal, for manufacturing TV display overlays and interactive whiteboards at the affordable cost point, validate possible issues with the manufacturing yields caused by novel aspects of the integration of large area electronics, and to articulate the companys commercialisation plans. The outcomes of the project will help to establish a pilot production capability and to secure further investment in scaling up our business with possible support from Phase 2 funding.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALTERIX LTD;UK;;; 194656;650314;CP2;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;CP2 is a project to develop a new wrist placement technology that can detect anomalies with both the Cardio and Vascular systems simultaneously.;1/10/2014;31/03/2015;;'Combined Pressure and Cardiac Performance (CP2) is a project that develops a diagnostic device that enables a paradigm shift in physiological performance analysis. CP2 utilises multi-modal sensing to identify both Cardiac Performance as well as Vascular system performance from the subject, in 30 seconds, with the subject remaining clothed. The CP2 system draws on the experience from monitoring high performance engines within the world of F1 motorsport and transfers these techniques into medical care. By using new diagnostic sensing technologies and by analyzing the data for Biomarkers, the project is be able to identify the following disorders of the Cardio-Vascular system. Hypertension, Peripheral Arterial Disease, Aortic Stenosis, Atrial Fibrillation, Atrial Flutter, Ectopic beats, Bradycardia, Tachycardia and Type 1 & 2 Heart Block. The CP2 system works by placing an array of sensors under both wrists, with the subject actively engaged in the process. No straps or restraints are involved, the subject remains in complete control at all times throughout the process and so there is the potential to reduce 'Hypertensive White Coat' syndrome. The new multimodal sensing system allows both the Vascular and Cardio side of the Heart and Circulatory system to be tested simultaneously and the results from both halves to the equation to be reviewed against each other. The CP2 project thus brings together existing physiological parameters in new forms that should not only allow the identification of known disease, but also might lead to the establishment of biomarkers previously undetected owing to the two systems being operated asynchronously. It is easy to produce a better incarnation of what has gone before, but CP2 seeks to produce a paradigm shift in the usage of medical devices in the proactive screening role. With a screening taking only 30 seconds the opportunity exists to optimise the patient care pathway and to enhance patient flow within Primary Care locations.';71429;50000;H2020-SMEINST-1-2014;SME-1;CARDIOCITY LIMITED;UK;;; 194943;654166;CREMLIN;SIGNED;H2020-EU.1.4.3.2.;INFRASUPP-6-2014;H2020;Connecting Russian and European Measures for Large-scale Research Infrastructures;1/09/2015;31/08/2018;;"This CREMLIN proposal is to foster scientific cooperation between the Russian Federation and the European Union in the development and scientific exploitation of large-scale research infrastructures. It has been triggered by the recent so-called megascience projects initiative launched by and in the Russian Federation which is now very actively seeking European integration. The proposed megascience facilities have an enormous potential for the international scientific communities and represent a unique opportunity for the EU to engage in a strong collaborative framework with the Russian Federation.
The CREMLIN proposal is a first and path finding step to identify, build and enhance scientific cooperation and strong enduring networks between European research infrastructures and the corresponding megascience facilities to maximize scientific returns. The proposal follows the specific recommendations of an EC Expert Group by devising concrete coordination and support measures for each megascience facility and by developing common best practice and policies on internationalisation and opening.
CREMLIN will thus effectively contribute to better connect Russian RIs to the European Research Area.";1696250;1696250;H2020-INFRASUPP-2014-2;CSA;STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY;DE;"FACILITY FOR ANTIPROTON AND ION RESEARCH IN EUROPE GMBH;FORSCHUNGSZENTRUM JULICH GMBH;ASSOCIATION INTERNATIONALE EXTREME-LIGHT-INFRASTRUCTURE DELIVERY CONSORTIUM;EUROPEAN SPALLATION SOURCE ESS AB;Budker Institute of Nuclear Physics of SB RUS;TECHNISCHE UNIVERSITAET MUENCHEN;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;JOINT INSTITUTE FOR NUCLEAR RESEARCH;EUROPEAN SYNCHROTRON RADIATION FACILITY;RUSSIAN RESEARCH CENTRE KURCHATOV INSTITUTE;A.V. SHUBNIKOV INSTITUTE OF CRYSTALLOGRAPHY RUSSIAN ACADEMY OF SCIENCES;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;INSTITUT MAX VON LAUE - PAUL LANGEVIN;FEDERAL STATE BUDGETARY ORGANIZATION B.P. KONSTANTINOV PETERSBURG NUCLEAR PHYSICS INSTITUTE;INSTITUTE OF APPLIED PHYSICS, RUSSIAN ACADEMY OF SCIENCES;LUNDS UNIVERSITET;HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH;EUROPEAN X-RAY FREE-ELECTRON LASERFACILITY GMBH";"DE;BE;SE;RU;FR;CH"; 194616;649767;RESCOOP MECISE;SIGNED;H2020-EU.3.3.7.;EE-20-2014;H2020;RESCOOPs Mobilizing European Citizens to Invest in Sustainable Energy;1/03/2015;28/02/2019;;RESCOOP MECISE is short for Renewable Energy Sources COOPeratives Mobilizing European Citizens to Invest in Sustainable Energy. As European citizens and local authorities often lack time, financial means and technical expertise to initiate the necessary energy renovations of their houses and public buildings, the potential for energy efficiency projects remains largely untapped. RESCOOP MECISE will develop an integrated and innovative approach that gives answer to this impeding challenge. By integrating both renewable energy and energy efficiency projects into one innovative investment scheme RESCOOP MECISE will elaborate a completely new financing format. The financing scheme will make European citizens, REScoops, local authorities, the European Investment Bank and other related investment funds partners into the transition towards a more sustainable society. Moreover RESCOOP MECISE will encourage citizens and local authorities to initiate deep energy renovation projects by providing them with personal assistance and technical expertise that now remains with the REScoops. The RESCOOP MECISE project will also provide a clear cut solution for the financing problem that REScoops face when they want to start up with their first project. By means of setting up a European fund for both renewable energy and energy efficiency projects or through the development of a financial facilitation service for REScoops the REScoop MECISE project will enhance the potential for more successful energy efficiency projects throughout Europe.;2185000;2185000;H2020-EE-2014-4-PDA;CSA;ECOPOWER;BE;"ENERCOOP;COURANT D AIR SCRL FS;RESCOOP EU ASBL;ENERGY4ALL LTD;SOM ENERGIA SCCL";"FR;BE;UK;ES"; 194754;651829;PILOTS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Prototyping Internet Lot of Things Software;1/10/2014;31/03/2015;;"Virtual platforms have been mainly used to support anticipation of embedded software (eSW) development of very complex System on Chip (SoC) or for Software-based functional validation of complex IP. The explosion of the number of connected things change the complexity paradigm: the challenge is now to manage hundreds of distributed platforms (SoCs or boards) that include processors, sensors, MEMs and communication devices.

Using physical board to prototype each of these platforms to verify the overall system behaviour is too expensive and not scalable for system providers. System integrators require a scalable solution for system prototyping. The use of virtual platforms appears to be the answer, but they lack tools to deploy and integrate this solution in their prototyping flow.

According to state of the art and technical analysis with CEA and Fraunhofer, no such solution is available today; as a long time provider of hardware integration platform, Magillem has been a pioneer in design environment software for SoC integration and SoC virtual platform since its early days and believe to be in a unique position to introduce a very innovative solution for IoT enablement. By using PILoTS, European leading system integrators, as well as suppliers of MEMS, micro-controllers, connected systems would save time and cost, during design, verification and certification, and vastly improve their competitiveness.";71429;50000;H2020-SMEINST-1-2014;SME-1;MAGILLEM DESIGN SERVICES SAS;FR;;; 194666;650506;16gAirTest;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Development of replacement method for all kind of 16g dynamically tested aircraft cushions.;1/10/2014;28/02/2015;;"'Airline operators are faced with increased need to replace passengers seat cushions, certified for security standards at sustainable retrofit costs. Since October 2009, the Federal Aviation Administration (FAA) regulation 121-135 has imposed more strict standards for aircraft seats, which must sustain a load of 16g in forward direction and 14g in down direction. As a consequence airlines need to gradually replace current '9g seats' (approx. 65% of current aircraft seats) with new ones compliant with the 16g standard. At present the 16g certification requires testing of the entire seat, which may cost up to 1,3 K/pax. while a new certified cushion may cost 200-250 . The aircraft cushions and seats market is almost totally occupied by a few manufacturers who keep prices high, especially when the original cushion model is phased-out and either the entire seat must be replaced, or costly custom-made cushions produced. Consequently many airlines avoid replacement or adopt non-standard cushions, despite risks for passengers' safety. Testori Aero Supply has achieved a EASA approval for a certification method for 16g monolithic cushions, and has already produced such replacement cushions for a client on a Boeing B777. At present Testori is the only independent company holding this qualification. This project intends to exploit this method to the certification of 16g multilayer cushions, and to produce and sell them at a competitive price of 200-250.
The feasibility study will assess the market positioning, the industrialization and production costs, the market demand and the market potential for the company, taking into consideration the customers (airline operators) and the aircraft fleets (current and new) in the areas where Testori already successfully operates. The project will open new business in airplane retrofit market for Testori and increase competitiveness for European SMEs operating in this field.'";71429;50000;H2020-SMEINST-1-2014;SME-1;TESTORI AERO SUPPLY SRL;IT;;; 194651;650216;OntoPerson;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Ontology of Personal Identity;1/09/2015;31/08/2016;;"'Animalism and the so-called simple view, among many others, constitute competing theories of personal identity. According to the first, persons are biologically individuated animals whose persistence through time consists of some kind of biological continuity. According to the latter, there are no criteria of personal identity: no sort of continuity is both necessary and sufficient for a person to survive. Although these theories usually stand in radical opposition, there is, nevertheless, room for a possible link between them. The main objective of this project is to demonstrate that under certain assumptions both theories are reconcilable and that the combined position has measurable theoretical and practical advantages over existing approaches. In this project I intend to develop a new approach to human persons, according to which it would be possible, first, to reconcile some thus far contradictory conceptions of the human person and personal identity, second, to solve some of the interpretational difficulties concerning issues related to personal identity and constitution, third, to give a coherent and uncontroversial philosophical two-fold picture of human beings, enabling rational decision-making in the areas that are of practical importance. The consecutive research stages of the project are: (1) an analysis of various forms of the so-called simple view with regard to personal identity; an analysis of the criteria of personhood and of the ontological structure of persons; an examination whether the term 'person' is a sortal term (resp. whether persons comprise a natural kind); (2) a reconstruction of differences between many versions of animalism; a reconciliation of a specific form of the simple view with a chosen version of animalism; (3) a verification whether the obtained results have any bearing on the debates in philosophical thanatology and bioethics.'";85730,4;85730,4;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSITAET AUGSBURG;DE;;; 194705;651084;iMUC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Improving the Management of Unexplained Chest-pain;1/11/2014;30/04/2015;;"The iMUC project is designed to validate the improvement of cardio vascular outcomes in patients with unexplained chest-pain using a novel methodology of endothelial function diagnosis and adjusting their treatment, including life style modification, accordingly. iMUC is focused on the validation of a new biomarker based non-invasive novel technology which detects and scores endothelial dysfunction in cardiovascular disease through the different states of the disease.
iMUC EndoPATTM diagnostic technology is based on the PAT signal biomarker developed by Itamar Medical. It is a non-invasive, robust and totally non-operator-dependent technology and thus could fit well into clinical settings, providing an enhanced tool to improve disease management.

iMUC aims to validate that endothelial function as scored by the iMUC technology can help to better manage patients with chest pain that undergo diagnostic angiography and are released without intervention. In addition, iMUC aims to show and validate in the same patient population that adherence to and compliance with intensive life style changing is improved when progress is followed and monitored with the novel iMUC technology.

iMUC Phase I study will focus on the development of a business plan, and on a feasibility study of the project's concept. It will conduct a clinical market research quantifying the relevant market segments as well as their size, by studying the related health care economic viability, and the relevant scientific literature. iMUC feasibility study will include the establishment of a steering committee composed of relevant Key Opinion Leaders (KOLs), the detailed design of the project clinical protocol, the plan of the project risk management, as well as conducting a partner search including medical centers, CRO, and a bio-statistic group.";71429;50000;H2020-SMEINST-1-2014;SME-1;ITAMAR MEDICAL LTD;IL;;; 194835;653203;EU-LIVE;SIGNED;H2020-EU.3.4.;GV-5-2014;H2020;Efficient Urban LIght VEhicles;1/06/2015;31/05/2018;;"'EU-LIVE will provide a comprehensive European solution for the next generation of electrified, cost- and energy-efficient light urban vehicles to cope with the challenges of future personal urban mobility, based on both user needs and acceptance.

EU-LIVE will establish the 'EU-LIVE modular platform', a systematic approach for efficiently designing, developing and building a wide range of L-category vehicles from more close-to-the-market to radically new ones. This comprises a set of modular electrified powertrain components and subsystems for PHEVs and BEVs, modular bodies (within the same L-vehicle class), and an integrated modular co-simulation platform to guarantee re-usability, flexibility and sharing of components as well as subsystems for L-category vehicles.

EU-LIVE will provide innovative solutions regarding cost-efficient, energy-efficient, low-emission and low-noise powertrains (in-wheel motors, novel highly efficient transmission for PHEV, 48V batteries \ electric board net) and future-proof, flexible and scalable vehicle architectures. To leverage expertise beyond the consortium, an open innovation contest for a radically new light vehicle based on the EU-LIVE modular platform will be carried out. Eventually, both real and virtual full-vehicle demonstrators (L5e PHEV 3-wheeler beyond EURO 5, L3e BEV 2-wheeler, L6 BEV 4-wheeler) will be shown.

By its modular approach and the efficient transfer of expertise from high-volume automotive to low-to-medium-volume light vehicle industry, EU-LIVE will enable economies of scale, therefore overcoming a major barrier to affordable light urban vehicles. Through its excellent partner consortium - including 2 OEMs and several key suppliers - EU-LIVE is able to credibly provide a clear route to market for a range of different L-category vehicles which feature series producibility, attractive cost-of-ownership, full comfort, safety and connectivity, for both European and non-European markets.'";6713338,75;6713338,75;H2020-GV-2014;RIA;Kompetenzzentrum - Das Virtuelle Fahrzeug, Forschungsgesellschaft mbH;AT;"SAMSUNG SDI BATTERY SYSTEMS GMBH;ELAPHE POGONSKE TEHNOLOGIJE DOO;SPIRIT DESIGN - INNOVATION AND BRAND GMBH;PEUGEOT MOTOCYCLES;MONDRAGON GOI ESKOLA POLITEKNIKOA JOSE MARIA ARIZMENDIARRIETA S COOP;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;PEUGEOT CITROEN AUTOMOBILES S.A.;FRENI BREMBO Spa;fka Forschungsgesellschaft Kraftfahrwesen mbH Aachen;Continental Automotive GmbH;IFP Energies nouvelles;MAGNA STEYR BATTERY SYSTEMS GMBH & CO OG";"AT;SI;FR;ES;DE;IT"; 194690;650877;AST-FCS_vF;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;ADAPTIVE SELF-TUNING FLIGHT CONTROL SYSTEM COMPLETE AND QUALIFIED;1/10/2014;31/03/2015;;"The objective of the overall innovation project is the commercialization of the first Adaptive Self-Tuning Flight Control System
(AST-FCS) in the history of aeronautics, based on internationally patented ADEX technology.";71429;50000;H2020-SMEINST-1-2014;SME-1;ADAPTIVE PREDICTIVE EXPERT CONTROL ADEX SL;ES;;; 194759;651956;PREMADES;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Preterm Feeding Maturity Measurement and Evaluation;1/10/2014;31/03/2015;;The aim of the proposed product is to detect the feeding maturity of preterm babies in an objective manner, by analyzing the swallowing patterns acquired using sensors placed around their hyoid regions. It is also intended to monitor the improvements by regular measurements and analysis of feeding maturity in the preterm infants and compare past evaluations. The product is expected to be proper for point of care usage, marketable globally. Moreover, this non-invasive design will be painless for infants and user friendly for the medical staff. Currently, in practice, doctors utilize observational, trial-and-error techniques or nursing assessment for identification of feeding skills in preterm infants which are mostly subjective. Efforts aimed at more objective assessment techniques have focused on invasive, pressure measurement methods that can be particularly painful for infants. However, such methods are not well suited for regular and real-time monitoring of feeding maturity, thus are not preferred in practice. If successfully completed, the proposed business idea, which aims to detect the feeding maturity by tracking swallowing function merely with sensors placed around infants hyoid regions, will meet a highly important need, particularly in the neonatal medicine. At the end of Phase-1, an intensive feasibility study, including market and profitability analyses, and a work plan for Phase-2, which will lead us to the final product on the shelf will be produced. Furthermore in Phase-1, in addition to the feedbacks from the medical staff experimenting with the device, possible improvements required for the prototype will be determined by surveying the point of care medical devices used in the newborn units of the hospitals. Moreover, collaboration opportunities in European countries will be investigated which will be instrumental for forming a consortium in the Phase-2 project. Furthermore, in Phase-1 certification costs and duration will be estimated.;71429;50000;H2020-SMEINST-1-2014;SME-1;KUARTISMED MEDIKAL ARASTIRMA GELISTIRME DANISMANLIK EGITIM SANAYI VE TICARET LIMITED SIRKETI;TR;;; 194602;649690;HERON;SIGNED;H2020-EU.3.3.6.;EE-12-2014;H2020;Forward-looking socio-economic research on Energy Efficiency in EU countries.;1/05/2015;30/11/2017;;"HERON aims at facilitating policy makers of multi-level governance in EU, to develop and monitor energy efficiency policies in building and transport sectors, through forward-looking socio-economic research in seven EU and one candidate countries.
The objectives are: i. the impact of socio-economic and institutional factors on implementing energy efficiency policies and measures, ii. the development of energy-efficient pathways to the horizon 2030 and beyond taking into account the socio-economic drivers and the updated energy efficiency measures, iii. the contribution to improving energy modeling by incorporating social, educational and cultural factors so as to reflect the end-user behavior, iv. the establishment of communication channels between researchers, decision makers of different governance levels and social and market stakeholders.
These objectives will be achieved through: (1) Mapping of energy efficiency policy instruments, available technologies and social, economic, cultural and educational barriers in transport and buildings, (2) Assessment of the evidenced barriers and the main driving factors, in order to define their weight/importance for the implementation of energy efficiency policies, (3) Determination of linkages between the factors and the energy efficiency, (4) Forward-looking scenario analysis, focusing on macro- and micro-economic impacts of energy efficiency policy options, (5) Policy recommendations through multi-criteria evaluation and feedback mechanisms with policy makers and market stakeholders from EU (member states, Covenant of Mayors) and neighboring countries (Business Council of BSEC).
HERON will develop an innovative decision support tool to incorporate non-economic and non-market elements, such as social, educational and cultural, into scenario analysis.";958750;958750;H2020-EE-2014-2-RIA;RIA;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;EL;"SIHTASUTUS STOCKHOLMI KESKKONNAINSTITUUDI TALLINNA KESKUS;UNIVERSITEIT ANTWERPEN;UNIVERSITA COMMERCIALE LUIGI BOCCONI;WUPPERTAL INSTITUT FUR KLIMA, UMWELT, ENERGIE GMBH;OXFORD BROOKES UNIVERSITY;UNIVERSITY OF BELGRADE - FACULTY OF MINING AND GEOLOGY;SDRUZHENIE CHERNOMORSKI IZSLEDOVATELSKI ENERGIEN TSENTAR";"EE;BE;IT;DE;UK;RS;BG"; 194712;651167;ELOXIRAS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Electrochemical Oxidation in the Recirculating Aquaculture Systems Industry;1/10/2014;31/03/2015;;"ELOXIRAS is an innovative water treatment concept specially developed to improve the productivity and environmental impact of marine RAS used by the exponentially growing aquaculture industry.
Worldwide aquaculture sector is a market with an annual average growth of 10%. At European countries the aquaculture industry production is about 1.26 Mt/year. Aquaculture sector is a successful business opportunity
The economic feasibility of inland hatchery aquaculture activities requires high biomass culture densities (kg species /m3 of water). Recirculating Aquaculture Systems (RAS) are emerging as the preferred technology to provide adequate culture water quality in hatchery activities. RAS production within EU is conservatively estimated in 0.029 Mt/year with a market value of 175 M/year and an average growing rate of 14%/year. RAS industry is mainly established in The Netherlands and Denmark with raising interest in other European countries, for example Spain.
ELOXIRAS is an innovative treatment of the culture water from marine RAS hatcheries, which is based on electrochemical oxidation technology. The novelty respect to the main competitors is related to:
- High efficiency and removal of all key pollutants, including bacteria and virus.
- Compact and modular design.
- Reduction of water and energy requirements.
- Easy to operate with adaptable capacity to required productivity.
The introduction of ELOXIRAS improves the annual benefits and/or the environmental impact of the marine RAS equipped with existing competitor solution (biofilter\ozone). Thus, the introduction of this process into the actual aquaculture industry constitutes an advantaged business opportunity.
The main objective of the present proposal (phase 1) is the determination of the ELOXIRAS technological and economic feasibility. After checking its feasibility a ELOXIRAS prototype will be developed in order to conduct several demonstration activities (phase 2)";71429;50000;H2020-SMEINST-1-2014;SME-1;APRIA SYSTEMS S.L.;ES;;; 194636;649956;FESTA;SIGNED;H2020-EU.3.3.7.;EE-20-2014;H2020;Fostering local energy investments in the Province of Matera;1/03/2015;31/08/2017;;"FESTA has the overall objective to foster local energy investments on public buildings (primarily in schools, a significant target in Italy for energy efficiency) and to spread the PPP approach also through the innovative, for the context, Energy Performance Contracts (EPC) in convergence regions.
The main specific objectives of the proposed action are:
1. to define technical, financial, legal and administrative specifications of a package of investments that are economically sustainable and attractive for private investors;
2. to assess a PPP scheme and to define an EPC model for the energy efficiency of public buildings, also to create better condition to renewal this aged (> 30 years) buildings;
3. to publish the call for tender and to procure the bundled investments through EPC and sign the investment contracts;
4. to become a best practice for the mobilisation of local energy investments of the area where municipalities are preparing the SEAPs (Province of Matera leader of this project is the coordinator);
5. to share all this advances with local actors and other MLEI European partners.
Specifically, the project (regarding a complex of schools in Matera and in Policoro with the neighboring hospital) aims to experiment, with technological and method approaches, the achievement of the objective that all schools in the area become climate neutral by 2020.
The project also aim to generate capacity building in the field of renewable energy and energy saving through:
the inter-institutional collaboration between different public authorities to increase the interventions scale (that is very important considering both the small average size of the local administrations and the low population density);
the development of approaches that pay special attention to the potential of the PPP in the field of energy;
better understanding of the features that this kind of projects should have in order to be attractive to both lenders and ESCOs.";498157;498157;H2020-EE-2014-4-PDA;CSA;PROVINCIA DI MATERA;IT;"UNIVERSITA DEGLI STUDI DELLA BASILICATA;AZIENDA SANITARIA LOCALE DI MATERA";IT; 194586;649484;TransCrisis;SIGNED;H2020-EU.3.6.;EURO-4-2014;H2020;Enhancing the EU's Transboundary Crisis Management Capacities: Strategies for Multi-Level Leadership;1/04/2015;31/03/2018;;"The European Union (EU) is facing the daunting prospect of transboundary crises: threats that escalate across national borders and policy domains. EU member states must collaborate to address these crises. EU governance can play a pivotal role in facilitating a joint response. But does the EU have the institutional leadership capacities to deal with transboundary crises?
The response to the financial crisis a textbook example of a transboundary crisis revealed deep problems with crisis leadership, including conflicting diagnoses, regulatory gaps, unclear political jurisdictions and responsibilities, a lack of problem solving capacity, and blame-shifting. Growing euroscepticism has been directly related to the EUs role during this transboundary crisis.
This project outlines the institutional requirements for effective and legitimate crisis leadership in the face of transboundary crisis. We define crisis leadership as a set of strategic management functions, including the detection of impending threats, the collection and sharing of information, the coordination of partners, and the communication to the public about the crisis and the response.
The project analyses the capacities of political leaders in EU institutions and member states to fulfill these leadership functions. It will pinpoint the existing and required capacities to support these functions. It investigates the crisis management capacities of individual political leaders, and EU institutions. It explores the effects of political leadership on the member state level and studies how crisis management capacity is exercised in various policy sectors.
The project will result in recommendations for effective and legitimate crisis leadership. It establishes a crisis management capital index that allows for an evidence-based assessment. It proposes strategies to build support for transboundary crisis management in a multilevel system, reconnecting citizens with an idea of what the EU can do for them.";2280809,5;2280209;H2020-EURO-SOCIETY-2014;RIA;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;UK;"Crisisplan B.V.;TAENKETANKEN EUROPA (TAENKETANKEN);UNIVERSITEIT UTRECHT;UNIVERSITA DEGLI STUDI DI CATANIA;INSTITUT BARCELONA D ESTUDIS INTERNACIONALS, FUNDACIO PRIVADA;KOZEP-EUROPAI EGYETEM;STOCKHOLMS UNIVERSITET";"NL;DK;IT;ES;HU;SE"; 194739;651612;FINESSE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Feasibility of an INnovative, Efficient, Solid State Energy saving system;1/11/2014;30/04/2015;;The overall project objective is to successfully develop and to scale up for market readiness, a sophisticated voltage optimisation system that can reduce electrical energy consumption by up to 20%. The EU consume 3,361.69 TWh of electricity p.a and that is growing, as is our reliance on imported energy. EU supply standard EN 50160 has been harmonised at a single phase line voltage of 230Vac 10%, Consequently actual voltages differ significantly across Europe with from 220Vac, through 230 to 240Vac, with peak mean voltages up to 253Vac. Whilst initially perceived as a UK issue, there are in fact 11 EEA countries which have an upper limit of 230V \10%, and another 13 to follow. The Business Opportunity is that virtually all European electrical equipment is designed to operate most efficiently at 220Vac. This over voltage leads to inefficiency and losses, (heat, eddy currents, magnetic hysteresis), increased energy bills, increased maintenance, down-time and reduced equipment life. These problems can be solved by reducing and stabilising the line voltage at the point of use, results in energy savings up to 20% if the input line voltage is 253V (230V\10%), thus representing a significant opportunity to reduce electricity bills. As we will demonstrate in section 1.4, conventional solutions and the current state of the art, do not fully solve this problem and have a number of limitations. There is therefore an urgent, unmet need for a system to reliably optimise electrical energy savings and provide a rapid return on investment for the customer. Our breakthrough solution is novel, patent protected and tested at lab scale. We initially require help to undertake a feasibility study to elaborate and de-risk our business plan. If successful we will unlock a market opportunity of 70m, create 70 jobs, reduce energy costs by 228m and CO2 by 272,270 tonnes 5 yrs post project. Ultimately helping Europe achieve demanding 2020 targets.;71429;50000;H2020-SMEINST-1-2014;SME-1;POWER STABILISATION LIMITED;UK;;; 194695;650880;EFICONSUMPTION;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Innovative System for Electrical Energy Efficiency in industrial plants;1/10/2014;28/02/2015;;"The general objective of EFICONSUMPTION will be focused on the development and further commercialization of an innovative system able to reduce the electricity consumption in industries in a percentage up to 40%, related in terms of unitary energy cost, by means of an optimal measurement, monitoring, smart modeling, remote control and horizontal scalable management of industrial plant production and service processes.

The new solution will be a combination of a specific device able to measure the main electricity parameters at any place, and an expert system, which will receive the real time data and will be able to establish efficient consumption patterns to effectively reduce the electricity consumption. This reduction will also contribute to reduce carbon footprint and emissions.

EFICONSUMPTION has the following specific objectives to be accomplished in this first stage:
- To develop a business and exploitation plan adjusted to the technical and commercial features of the project, including the assessment of the cost-effectiveness and exploitation potential of the envisaged solution.
- To tackle the main bottlenecks and barriers for the full commercialization of the innovative technologies, mainly related to legislative and regulatory aspects in each country.
- To widely disseminate project outcomes to stakeholders and end-users, strengthening synergies with other initiatives and platforms to reach the maximum impact.
- To analyse the market and business strategies in the sector in order to find the best combination of external agents and international entities to develop cooperation strategies for market exploitation and further products commercialization.";71429;50000;H2020-SMEINST-1-2014;SME-1;CYSNERGY SL;ES;;; 194724;651425;HTSew;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Use of HTC technology as an innovative reuse method for sewage sludge;1/10/2014;31/03/2015;;"Efficient municipal wastewater treatment, such as the systems currently in place in most European municipalities, produces vast amounts of sewage sludge. The latest data collected show a yearly production of 9.637 thousands of tons in the EU28 countries. Sludge treatment issues are often neglected in comparison with water-related parameters which results in serious technical difficulties and highly expensive disposal methods. As a result, an energy efficient, environmentally sound and economically viable process for sludge disposal hardly exists.
The most common disposal methods for sludge are spreading on agricultural soil, composting and incineration. Landfilling has been long banned, the use as fertilizer, although very moderate in costs, is being banned in many regions due to concerns about contamination of soils with heavy metals and endocrine disruptive compounds. Composting raises the same concerns, and it is a labor-intensive and unsafe process, which leaves incineration as the most used option, albeit an expensive and not effective one. Incineration entails the highest costs (80-110 /ton), but is also considered the safest disposal method and is fast growing and widely adopted. It presents also technical difficulties, such as the low overall efficiency of the process, the huge logistic efforts required to transport the sludge to the incineration plants, or the disposal of the ashes after the sludge has been incinerated.
In this situation, the proposing company, Ingelia, has the objective to demonstrate and commercialize their proprietary technology for hydrothermal carbonization (HTC) to the conditions of sewage sludge, showing clearly technical and economic advantages compared to incineration. Ingelia aims to increase the amount of sludge converted into high value products such as fuel or activated carbons for water treatment. The HTSew process turns the sewage sludge disposal from a costly process into an income-generating activity.";71429;50000;H2020-SMEINST-1-2014;SME-1;INGELIA SL;ES;;; 194933;654123;GRENHAS;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Green and Smart Communications with Energy Harvesting: A Signal Processing Approach;1/03/2015;28/02/2017;;"Efficient usage of energy resources is a growing concern in today's communication systems. Solutions that consider energy harvesting, where nodes in a communication system utilize other available energy sources, such as solar, wind power or man made signals, instead of completely relying on a fixed battery or the power from the grid, offer a promising perspective. Such approaches have a wide range of applications including wireless sensor networks, smart homes and smart cities.
Understanding the information transfer capabilities of communication systems with energy harvesting features have been the attention of a number of recent works. At the moment the main line of research on the subject is typically done in an information theoretic framework with the rate maximization criterion. This line of work is important for understanding the fundamental limits in energy harvesting systems, yet it falls short in applicability in the context of practical scenarios.
Here we propose an alternative estimation theoretic perspective where the problem is investigated within a practical signal processing framework. We will focus on efficient transmission and resource allocation strategies. Practical receiver structures with linear filtering, low complexity designs such as linear precoders, power allocation methods will be important ingredients in our work. The resulting solutions will complement the existing information theoretic solutions, and contribute to creating future green and smart communication systems.";185857,2;185857,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;CHALMERS TEKNISKA HOEGSKOLA AB;SE;;; 194683;650946;SolDent;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;An innovative dental implant with osteoinductive properties by means of bioactive sol-gel coating;1/10/2014;31/03/2015;;"In the treatment of edentulous patients with dental implants, there are usually strict patient selection criteria based on well-recognised risk factors that are associated with poor bone-forming activity, such as diabetes, smoking or metabolic bone disorders. Therefore, many patients remain untreated with dental implant clinical practice. Additionally, the expectations of both surgeons and patients of shortening the recovery phase of the dental implant treatments have led Ilerimplant a well-recognised Spanish manufacturer of dental implants with an excellent worldwide network of distributors to develop an innovative osteoinductive dental implant by means of a biodegradable coating. The osteoinductive properties, one of the most desired in the last generation of dental implants but not reached yet, have been obtained by a bioactive organic-inorganic hybrid material specially tailored for this purpose by a sol-gel coating process.
Ilerimplants overall goals with this innovation project are to industrialise and introduce in the market a new generation of osteoinductive dental implants based on this sol-gel coating (SolDent). Taking into account that the global dental implant markets are continuously growing and that SolDent will be the unique product in the market with effective osteoinductive properties, Ilerimplant expects to make a qualitative leap in market shares and sales with an eminently European and international approach.
Firstly, we will conduct a practical and economic feasibility study in Phase 1 in order to assess the industrialisation process, regulatory issues and commercialisation strategy, ending with the elaboration of a comprehensive business plan. In Phase 2, we will address industrialisation and clinical trial in order to achieve full commercialisation during Phase 3.";71429;50000;H2020-SMEINST-1-2014;SME-1;ILERIMPLANT, S.L.;ES;;; 194621;649819;ENERWATER;SIGNED;H2020-EU.3.3.7.;EE-16-2014;H2020;Standard method and online tool for assessing and improving the energy efficiency of wastewater treatment plants;1/03/2015;28/02/2018;;"Waste Water Treatment Plants (WWTPs) is one of the most expensive public industries in terms of energy requirements accounting for more than 1% of consumption of electricity in Europe. EU Water Framework Directive (WFD) 91/271/CEE made obligatory waste water treatment for cities and towns. Now within the EU-27, the total number of WWTPs is estimated as 22.558, for which we can estimate a total energy consumption of 15,021 GWh/year. Although most of the objectives of the WFD in relation to water protection have been achieved, most of these aging plants show unsustainable energy consumption and must be optimized to the maximum and renovated accordingly. However, in Europe there is no legislation, norms or standards to be followed, and as consequence, a gigantic opportunity for reducing the public electric expense remains unregulated.

The main objective of ENERWATER is to develop, validate and disseminate an innovative standard methodology for continuously assessing, labelling and improving the overall energy performance of WWTPs. For that purpose a collaboration framework in the waste water treatment sector including research groups, SMEs, utilities, city councils, authorities and industry will be set up. ENERWATER will devote important efforts to ensure that the method is widely adopted. Subsequent objectives are to impulse dialogue towards the creation of a specific European legislation following the example of recently approved EU directives, to achieve EU energy reductions objectives for 2020, ensuring effluent water quality, environmental protection and compliance with the WFD.
These actions should bring European Water Industry a competitive advantage in new products development and a faster access to markets by facilitating evidence of reduction therefore fostering adoption on new technologies.";1731087;1731087;H2020-EE-2014-3-MarketUptake;CSA;UNIVERSIDAD DE SANTIAGO DE COMPOSTELA;ES;"TECHNISCHE HOCHSCHULE KOLN;ESPINA & DELFIN SL;ENERGIA TERRITORIO RISORSE AMBIENTALI - ETRA SPA;WELLNESS SMART CITIES SLU;ASOCIACION ESPANOLA DE NORMALIZACION;CRANFIELD UNIVERSITY;AGGERVERBAND;ARC-Net Applied Research On Cancer Centre, University of Verona";"DE;ES;IT;UK"; 194667;650507;CONCEPT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;CONductive fast Charge system for Electric buses in Public Transport;1/09/2014;28/02/2015;;"Heliox, a company specialized in switch mode power technology, is developing a Conductive Fast Charge System for buses which will offer a cost-effective breakthrough technology for zero emission public transport AND competitive strength to the European Bus manufacturing industry. Heliox' Conductive Fast Charge System is designed for opportunity charging at e.g. end of bus line, extending the range of an (H)EV. A minimal onboard energy storage, enough to reach the next charging station, becomes practically sufficient to optimally operate a vehicle with low TCO and high availability. Potential userds are: Potnetial users are public transport operators and European bus manufacturers.

The objective of this feasibility study is to further verify the technological /practical as well as economical viability of the product. The 6 months of Phase 1 will be used to develop a detailed business plan, strengthen the relationship with potential customers and partners and define the technology. Heliox intend to submit a Phase 2 appliciation after finishing Phase 1.";71429;50000;H2020-SMEINST-1-2014;SME-1;HELIOX BV;NL;;; 194620;649789;BEenerGI;SIGNED;H2020-EU.3.3.7.;EE-20-2014;H2020;Bundling sustainable energy investments for GIronas municipalities;1/04/2015;31/03/2018;;Gironas municipalities are mainly small so lack the technical or financial capacity to carry out ISE on their own. BEenerGI will support these municipalities from technical, legal and financial points of view. So in the next three years 6.48 MEUR of investments will be mobilized to increase energy efficiency in street lighting in 65 municipalities and 9.40 MEUR will be mobilized in energy efficiency investments in 85 public buildings. BEenerGI specific objectives are: launching sustainable energy investments to strengthen innovative organisational models, establishing and promoting a new funding scheme, capacity building among all key actors involved and final beneficiaries, opening access to energy consumption data and communication of results across Europe. BEenerGI is innovative both for the organisation of project development assistance (PDA) and for its proposed financial engineering. Regarding PDA innovation, the project will join investments in at least 15 packages in order to make them bankable. Regarding the innovation of the proposed financing engineering, BEenerGI will encourage contracts between municipalities and ESCOs or Small and Medium Enterprises-Micro-ESCOs Local energy sector SMEs (local maintainers, local energy suppliers,..). In some cases, Ddgi will give a subsidy of 2 MEUR to municipalities (during the whole period) to make the planned investments in public buildings bankable and to decrease the payback of these investments. BEenerGI foresees using the monitoring system for energetic consumption already installed in Covenant municipalities as a monitoring tool to evaluate the impact and results of the project. BEenerGI will disseminate its results among Covenant Coordinators or other local authorities that want to replicate these innovative organizational models to mobilize bankable bundled IES.;1024887,5;922398,75;H2020-EE-2014-4-PDA;CSA;DIPUTACION DE GERONA;ES;;; 194928;654065;EUDAT2020;SIGNED;H2020-EU.1.4.1.3.;EINFRA-1-2014;H2020;EUDAT2020;1/03/2015;28/02/2018;;"EUDAT2020 brings together a unique consortium of e-infrastructure providers, research infrastructure operators, and researchers from a wide range of scientific disciplines under several of the ESFRI themes, working together to address the new data challenge.

In most research communities, there is a growing awareness that the rising tide of data will require new approaches to data management and that data preservation, access and sharing should be supported in a much better way. Data, and a fortiori Big Data, is a cross-cutting issue touching all research infrastructures.

EUDAT2020s vision is to enable European researchers and practitioners from any research discipline to preserve, find, access, and process data in a trusted environment, as part of a Collaborative Data Infrastructure (CDI) conceived as a network of collaborating, cooperating centres, combining the richness of numerous community-specific data repositories with the permanence and persistence of some of Europes largest scientific data centres.

EUDAT2020 builds on the foundations laid by the first EUDAT project, strengthening the links between the CDI and expanding its functionalities and remit. Covering both access and deposit, from informal data sharing to long-term archiving, and addressing identification, discoverability and computability of both long-tail and big data, EUDAT2020s services will address the full lifecycle of research data.

One of the main ambitions of EUDAT2020 is to bridge the gap between research infrastructures and e-Infrastructures through an active engagement strategy, using the communities that are in the consortium as EUDAT beacons and integrating others through innovative partnerships.

During its three-year funded life, EUDAT2020 will evolve the CDI into a healthy and vibrant data-infrastructure for Europe, and position EUDAT as a sustainable infrastructure within which the future, changing requirements of a wide range of research communities are addressed.";19052882;18865385;H2020-EINFRA-2014-2;RIA;CSC-TIETEEN TIETOTEKNIIKAN KESKUS OY;FI;"ISTITUTO NAZIONALE DI GEOFISICA E VULCANOLOGIA;EUROPEAN MOLECULAR BIOLOGY LABORATORY;HELSINGIN YLIOPISTO;CINECA CONSORZIO INTERUNIVERSITARIO;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;FORSCHUNGSZENTRUM JULICH GMBH;THE UNIVERSITY OF EDINBURGH;UNINETT SIGMA AS;UNINETT SIGMA2 AS;UNITED KINGDOM ATOMIC ENERGY AUTHORITY;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;Uppsala universitet;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;E-SCIENCE DATA FACTORY;CINES;SURFSARA BV;JISC LBG;UNIVERZITET U NOVOM SADU;INSTYTUT CHEMII BIOORGANICZNEJ POLSKIEJ AKADEMII NAUK;CENTRE EUROPEEN DE RECHERCHE ET DE FORMATION AVANCEE EN CALCUL SCIENTIFIQUE;STICHTING LIBER;KARLSRUHER INSTITUT FUER TECHNOLOGIE;UMWELTBUNDESAMT GMBH;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CLARIN ERIC;LUNDS UNIVERSITET;EBERHARD KARLS UNIVERSITAET TUEBINGEN;UNIVERSITY COLLEGE LONDON;HELMHOLTZ ZENTRUM POTSDAM DEUTSCHESGEOFORSCHUNGSZENTRUM GFZ;DEUTSCHES KLIMARECHENZENTRUM GMBH;ETHNIKO DIKTYO EREVNAS TECHNOLOGIAS AE;KONINKLIJK NEDERLANDS METEOROLOGISCH INSTITUUT-KNMI;BIOSENSE INSTITUTE - RESEARCH AND DEVELOPMENT INSTITUTE FOR INFORMATION TECHNOLOGIES IN BIOSYSTEMS;TRUST-IT SERVICES LIMITED";"IT;DE;FI;NL;UK;NO;SE;ES;FR;RS;PL;AT;CH;EL"; 194641;650018;SPS_TFP_Strut;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Application of tailored fibre placement technology in integral composite structures for ultra-lightweight space applications;1/10/2014;31/03/2015;;"The project is intended to investigate feasibility of applying the tailored fibre placement (TFP) technology for design and manufacturing of composite structural parts for space applications.

One structural element commonly used in load carrying structures for space is the strut. Struts attachment fittings have been impossible to manufacture with lightweight FRP (fibre reinforced polymer) materials due to limitations of the FRP manufacturing technologies. State-of-the-art is therefore a CFRP tube with bonded metallic fittings.

With the recent evolvement of TFP technologies in terrestrial applications, Space Structures is convinced that it is possible to manufacture and qualify fully integral CFRP struts, including CFRP fittings, for space applications.

The TFP strut product targets 3 areas of concern to our customers, the space industry:
Ultra-lightweight, due to replacement of metallic fittings, with CFRP and maximum efficiency carbon fibre orientation and continuity along the load paths
Cost and manufacturing time reduction, due to cheaper material, manufacturing automation and simplification of processes
Environmental friendly. Smaller footprint because the energy intensive manufacturing and chemical bonding of metallic fittings is removed from the process. Ultra-light structures also reduce the propellant consumption during launch of space vehicles.

By using the most innovative technology for CFRP manufacturing, all aspects of the product are improved and consequently the worldwide commercial potential is immense, ultimately redefining the state-of-the-art.

The feasibility study in phase 1 will investigate if this type of structure can be designed to meet space requirements and will conclude with the manufacturing of a prototype. A feasibility report and a business plan for the product will be delivered.

A potential phase 2 will aim at achieving space qualification by extensive testing, a prerequisite to enable market access.";71429;50000;H2020-SMEINST-1-2014;SME-1;SPACE STRUCTURES GMBH;DE;;; 194820;652871;FIBERSTAR;TERMINATED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;FIBER-optic sensors for Smart Thermal Ablation at Radiofrequency;1/09/2016;31/08/2018;;"FIBERSTAR is a multidisciplinary project aimed at the development of point-of-care optical fiber sensors to support non-invasive radiofrequency thermal ablation (RFTA) of tumors.

RFTA is an interventional medical procedure that brings tumor cells to mortality by generating a spatially selective high-temperature field, localized within the tumor, using a percutaneous ablation device. RFTA provides ablation up to 5 cm size in hard tissues (kidney, lung), while ablation size is limited to 3 cm in liver; on the other hand, the miniature ablation device ensures a non-invasive outpatient treatment.

In clinical procedures, RFTA is an image-guided procedure, which limits its efficiency. The possibility to install miniature, biocompatible, and quasi-distributed fiber-optic sensors on RFTA device, returning real-time biophysical data, can disrupt RFTA procedure. The applicant has carried out significant groundwork in the application of optical fiber sensors to ex-vivo thermal ablation on porcine liver phantoms.

Building on groundwork, FIBERSTAR aims at the development of innovative fiber-optic sensors that aim at solving the main limitations of RFTA. Research addresses the development of (1) a sensor embedding pressure and distributed temperature on a single fiber, to be installed on the RFTA device, (2) a sensor for positioning RFTA device in tumor, (3) miniature quasi-distributed temperature sensors to detect the approaching of the ablation.

FIBERSTAR aims at building four-fold impact:
1) Implement and demonstrate smart-RFTA, whereas real-time sensors data are used to drive the RFTA treatment in close-loop complementing imaging data.
2) Extend RFTA to safe treatment of prostatic and pancreatic tumors, using sensors to protect key organs from ablation.
3) Provide disruptive improvement of treatment of encapsulated tumors, implementing pressure detection.
4) Provide a quantified improvement of RFTA outcome in terms of reduction of failure rate and predictability.";158121,6;158121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;UNIVERSIDAD CARLOS III DE MADRID;ES;;; 194744;651665;BMEVLP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Biomarkers for clinical assessment of lungs intended for transplantation;1/11/2014;30/04/2015;;"Lung transplantation is the only therapeutic option for selected patients suffering from end-stage lung diseases. 80% of all donated lungs are not used for transplantation. The main reason is uncertainty of the function and quality of the lung.

Ex vivo lung perfusion (EVLP) is a technique used to assess quality of lungs prior to transplantation. In collaboration with leading clinical scientists, XVIVO has developed solutions and systems for EVLP. EVLP has recently become internationally clinically accepted. More than 300 patients have received transplanted lungs that would otherwise not have been used. Centers establishing a clinical program for EVLP increase the number of lung transplantations significantly. Clinical outcomes are at least equivalent to outcomes for patients receiving standard lungs. However, in order to disseminate the EVLP technique to a broader range of hospitals, it is necessary to offer objective metrics assessing lung function in addition to the subjective assessment methods used today.

Exploitation of EVLP has an impact for XVIVO. Each EVLP generates an income of about 15 000. Today about 5000 lung transplantations are performed each year. If we can reach 25% increase, it would contribute to a revenue increase of at least 18 MEUR. It also means that 1250 critically ill patients on the waiting lists will receive new lungs. The true potential is to increase the utilization rate of donated lungs to 40-60%.
The project aims to carefully select optimal biomarkers in phase 1 and confirm validity and clinical relevance in phase 2 through a clinical study. By introducing new biomarkers, XVIVO will be able to commercialize a device that will broaden the companys product portfolio and fulfill the customer need for validated tools making clinicians more comfortable to use donated organs that are being discarded today. The project will be performed in collaboration with identified biomarker companies and thus also catalyze their access to market.";71429;50000;H2020-SMEINST-1-2014;SME-1;XVIVO PERFUSION AKTIEBOLAG;SE;;; 194623;649829;multEE;SIGNED;H2020-EU.3.3.7.;EE-07-2014;H2020;Facilitating Multi-level governance for energy efficiency;1/03/2015;31/08/2017;;"MultEE aims to improve the ease and quality of energy efficiency (EE) policy planning and implementation in the projects partner countries and beyond, addressing the challenges of evidence-based policy-making in a multi-level governance setting. It contributes to making EE and sustainable energy planning vertically consistent between the national, regional and local level, to facilitating horizontal coordination between policy levels and to improving the quality of monitoring energy efficiency.
The project pursues a two-faceted, yet integrated, approach in order to reach this objective: (1) building on a mapping of European best practices and experience from a pilot project carried out by the lead partner, country-specific solutions for effective monitoring and verification (M&V) based on bottom-up data will be developed and their implementation supported; (2) the implementation of innovative M&V schemes will be facilitated via coordination mechanisms developed and introduced together with the partners, aimed at spurring on exchange and cooperation between policy levels. The project pays particular attention to providing opportunities for peer learning between old and new EU Members States and neighbouring countries from Southeast Europe to partner countries from the EU and its South-Eastern neighbourhood as well as to disseminating results beyond partner countries and to other policy areas. One of the specificities of multEE is that its activities target the interplay between administrative levels rather than focusing on a single one of them.
Particular focus will be put on capacity-building for the entities and officials involved with EE planning in the partner countries. MultEE will be put in practice by experienced partners within a strong consortium led by GIZ, drawing upon solid experience and a well-established network of contacts to ensure dissemination and high impacts within and beyond the project.";1981743,75;1981743,75;H2020-EE-2014-3-MarketUptake;CSA;DEUTSCHE GESELLSCHAFT FUR INTERNATIONALE ZUSAMMENARBEIT (GIZ) GMBH;DE;"SLOVENSKA INOVACNA A ENERGETICKA AGENTURA;CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;ECOLOGIC INSTITUT gemeinntzige GmbH;ROSKILDE UNIVERSITET;OSTERREICHISCHE ENERGIEAGENTUR AUSTRIAN ENERGY AGENCY;LIETUVOS ENERGETIKOS INSTITUTAS;FIZIKALAS ENERGETIKAS INSTITUTS;ENERGETSKI INSTITUT HRVOJE POZAR;MACEDONIAN CENTER FOR ENERGY EFFICIENCY SKOPJE-MACEF ASSOCIATION";"SK;EL;DE;DK;AT;LT;LV;HR;MK"; 194675;650655;QFast2;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Fast Multitarget Pathogen Detection Platform Traceable within a Quality Assurance System;1/10/2014;31/03/2015;;"Every year, millions of people become ill and thousands die as a result of eating unsafe food. According to the European Food and Safety Authority more than 320,000 human cases of food-borne diseases caused by pathogenic micro-organisms are reported each year in Europe. For that reason, the European Food Safety Authority is imposing strict food safety regulations specifying the maximum permitted level of any contaminant in food. EFSA has also specified that all food manufacturers are responsible for safety of the food they commercialize. The implementation of these regulations has resulted in the growth of the food safety testing market as well as new innovative technologies for detection of all kinds of pathogens.

In this regard, the project QFast2 aims at performing a feasibility study for the market introduction of the first Rapid Multi-Target Pathogen Detection Kit in development by iMICROQ. This is a revolutionary product that will enable the fast (<24h), cost-effective and simultaneous detection of three different pathogens (Salmonella, Listeria Monocytogenes and Staphylococcus) directly on-site for food&feed safety industry by non-specialised personnel, with a platform that allows the user to implement the instrument within its own information technology protocol, with full traceability of the sample through the overall process.";71429;50000;H2020-SMEINST-1-2014;SME-1;INTEGRATED MICROSYSTEMS FOR QUALITYOF LIFE, SOCIEDAD LIMITADA;ES;;; 194571;649307;HERA JRP UP;SIGNED;H2020-EU.3.6.;REFLECTIVE-1-2014;H2020;HERA Joint Research Programme Uses of the Past;1/01/2015;31/12/2019;;"Abstract
The HERA Joint Research Programme Uses of the Past (HERA JRP UP) consortium will establish a 3rd joint transnational programme for multi-disciplinary research into a topic at the heart of the reflective society: Uses of the Past. The innovative projects funded will fundamentally link past(s), present and future(s) creating valuable new knowledge that gives insights into the forces shaping the social, cultural and political transformation in Europe today.
The HERA JRP UP will also pursue additional activities aiming at international capacity-building in humanities research, promoting embedding of humanities researchers in Horizon 2020, and will explore and prepare new joint actions.

Twenty-four organisations from 23 countries have pooled a substantial amount of their humanities research funding (21 M EUR) for this HERA JRP, thus increasing the efficiency and impact of public funding. The HERA JRP UP involves the launch of a joint Call for Proposals and a commonly-agreed two-stage evaluation process involving an independent, international Review Panel. The consortium expects to fund 21 transnational humanities centred projects of ~1.2 M EUR each. EC support is awarded to the level of 33% of the joint call budget. The HERA JRP UP consortium will actively support knowledge exchange activities and stimulate wider dissemination about the valuable contributions of new humanities research.

With this large transnational JRP and its associated activities the HERA JRP UP will mobilise the intellectual energies and collaborative potential of a wide range of humanities disciplines, and further develop the knowledge base of the European Research Area by sharing and debating interpretations of the human past and its relation to the present and future. While this proposal is for the delivery of the Uses of the Past programme, the wider vision of a collaborative, multi-disciplinary and impact-rich humanities sector across Europe is at the forefront of our collective endeavour.";20572084;5000000;H2020-REFLECTIVE-SOCIETY-2014;ERA-NET-Cofund;NEDERLANDSE ORGANISATIE VOOR WETENSCHAPPELIJK ONDERZOEK;NL;"Lietuvos mokslo taryba;DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;AKADEMIE VED CESKE REPUBLIKY;FONDS ZUR FRDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG;SIHTASUTUS EESTI TEADUSAGENTUUR;THE ICELANDIC CENTRE FOR RESEARCH;SCHWEIZERISCHER NATIONALFONDS ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG;THE ARTS AND HUMANITIES RESEARCH COUNCIL;FONDS VOOR WETENSCHAPPELIJK ONDERZOEK-VLAANDEREN;STYRELSEN FOR FORSKNING OG UDDANNELSE;VETENSKAPSRADET - SWEDISH RESEARCH COUNCIL;MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD;SUOMEN AKATEMIA;FONDS NATIONAL DE LA RECHERCHE;CONSIGLIO NAZIONALE DELLE RICERCHE;NORGES FORSKNINGSRAD;AN TUDARAS UM ARD OIDEACHAS;AGENCE NATIONALE DE LA RECHERCHE;VALSTS IZGLITIBAS ATTISTIBAS AGENTURA;HRVATSKA AKADEMIJA ZNANOSTI I UMJETNOSTI;Ministrstvo za izobrazevanje, znanost in sport;FONDS NATIONAL DE LA RECHERCHE SCIENTIFIQUE;FUNDACAO PARA A CIENCIA E A TECNOLOGIA;NARODOWE CENTRUM NAUKI";"LT;DE;CZ;AT;EE;IS;CH;UK;BE;DK;SE;ES;FI;LU;IT;NO;IE;FR;LV;HR;SI;PT;PL"; 194652;650236;SKEMAS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Share Knowledge for Effective Management of Aviation Safety;1/11/2014;30/04/2015;;"In aviation, experience has shown that accidents are often preceded by safety-related incidents and occurrences revealing hazards at technological level, human factors and organisational deficiencies, but solely reactive interventions have limited efficacy. Existing legislative acts of the Union impose obligations on organizations involved in aviation activities to establish occurrence-reporting systems in the context of their Safety Management System supporting the performance of safety and risk assessment evaluations, utilising appropriate methods and techniques, coupled with specific information about an organization. The implementation of occurrence reporting should be proportionate to the size of an organization and the scope of its activity. However, the community of SMEs active in Europe in Aviation face serious issues both of data availability and specific methodologies, due to the fact that they experience only very few occurrences and events per year and are not very familiar with practical implementation of risk assessment approaches. Consequently, they need data, information about incidents and abnormal occurrences, as well as useful correlations for hazards analysis.
This project aims at offering the possibility for SMEs to Share Knowledge for Effective Management of Aviation Safety (SKEMAS). The SKEMAS tool will enable SMEs both to fully comply with existing regulation and to enrich their usually scarce data sets in view for more complete and more realistic safety analysis. The generation of a shared database of methods for risk analysis and real data on occurrences and events will represent a substantial source of information and data shared amongst the various contributors, enabling to carry out valuable statistical analysis and risk assessment. Moreover, in strict compliance with the most recent EU regulations, such a database should ensure full protection from improper use of the data, deidentification of the sources and maximum confidentiality.";71429;50000;H2020-SMEINST-1-2014;SME-1;KITE SOLUTIONS SRL;IT;;; 194807;652677;AORAC-SA;SIGNED;"H2020-EU.3.5.;H2020-EU.3.2.";BG-14-2014;H2020;Atlantic Ocean Research Alliance Support Action;1/03/2015;29/02/2020;;"The Atlantic Ocean Research Alliance Coordination and Support Action (AORAC-SA) is designed to provide scientific, technical and logistical support to the European Commission in developing and implementing trans-Atlantic Marine Research Cooperation between the European Union, the United States of America and Canada. The Coordination and Support Action (CSA) is carried out within the framework of the Atlantic Ocean Research Alliance as outlined in the Galway Statement on Atlantic Ocean Cooperation (May 2013). Recognising the evolving nature of the Atlantic Ocean Research Alliance, the hallmark of this proposal is that it is flexible, responsive, inclusive, efficient, innovative, value-adding and supportive.

To support the Commission in negotiations with the USA and Canada on trans-Atlantic Ocean Research Cooperation, the AORAC-SA support and governance structure comprises a Secretariat and Management Team, guided by a high-level Operational Board, representative of the major European Marine Research Programming and Funding Organisations as well as those of the USA and Canada. This structure is further able to draw on significant marine research expertise and experience through its partner organisations

The CSA, reporting to the Commission representatives of the Atlantic Ocean Research Alliance, will be responsible for the organisation of expert and stakeholder meetings, workshops and conferences required by the Atlantic Ocean Research Alliance and related to identified research priorities (e.g. marine ecosystem-approach, observing systems, marine biotechnology, aquaculture, ocean literacy, seabed and benthic habitat mapping), support actions (e.g. shared access to infrastructure, dissemination and knowledge transfer, establishment of a knowledge sharing platform) and other initiatives as they arise, taking into account related Horizon 2020 supported trans-Atlantic projects (e.g. BG1, BG8 and BG13) and on-going national and EU collaborative projects (e.g. FP7).";4295137,5;3447000;H2020-BG-2014-1;CSA;MARINE INSTITUTE;IE;"INTERNATIONAL COUNCIL FOR THE EXPLORATION OF THE SEA;MINISTERIO DA CIENCIA E TECNOLOGIA;THE ICELANDIC CENTRE FOR RESEARCH;CIENCIA VIVA-AGENCIA NACIONAL PARA A CULTURA CIENTIFICA E TECNOLOGICA;WOC - WORLD OCEAN LIMITED;INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER;CONSORCIO PARA EL DISENO, CONSTRUCCION, EQUIPAMIENTO Y EXPLOTACION DE LA PLATAFORMA OCEANICA DE CANARIAS;HAVFORSKNINGSINSTITUTTET";"DK;BR;IS;PT;UK;FR;ES;NO"; 194793;652574;SMEphase1;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Go to market strategy and technology roadmap towards development of a new license product based upon Onomondo's (form. Hello World Mobile) innovative telecommunications software technology;1/02/2015;31/07/2015;;"Onomondo (form. Hello World Mobile) has created a unique telecom software technology to combine mobile networks across carriers and/or across borders, offering a complete seamless roaming free experience for the end user. We simply remove roaming on network level completely (and not just roaming charges). Our aim is strictly B2B, and our potential customers could be Mobile Network Operators (MNOs) and Mobile Virtual Network Operators (MVNOs).
Today the first part of the solution is being live tested together with telecom operators (MNOs) at network level in Scandinavia.
THIS PROJECT aims to investigate the market opportunities for the platform technology in order to investigate the opportunity of developing a new technology product.
The project will result in a technology roadmap of how the technology can be developed into a license product aimed at the (through the project) identified new target groups, together with a comprehensive market analysis and go to market strategy.";71429;50000;H2020-SMEINST-1-2014;SME-1;ONOMONDO APS;DK;;; 194729;651487;BIOCERAMINK;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;New ecological BIO CERAMIC INK based on bio-solvents for ink jet printing (BIOCERAMINK);1/11/2014;30/04/2015;;"The goal of BIOCERAMINK project is to commercialize a new type of ceramic ink produced using solvents obtained by vegetal oil instead of solvents made of glycol ether.
The BIOCERAMINK wil be derived from vegetable oils, easily available, improving even the graphics, reducing the fouling of the heads and bars of printers, eliminating clogging or the closing of the nozzles, improving and finally reducing the cost of the inks, of about 30%.
In this way the quality of the products will improve and consequently quality of the prints, without increasing production costs. It should be added that the development of vegetable-based inks can solve the problem of the reduced availability of hydrocarbon-based solvents, such as glycol ether (TPnB), due to an over-production of related compounds pollutants, little used.
The expected results at the end of overall innovation project will be:
1. new marketable ecological products, with low content of alcohol, reduced effects of sedimentation and new range of pigments (colors);
2. full range of produce prototype inks based on components renewable and capable of becoming industrial products (pre-industrial prototypes)
3. full demonstration of BIOCERAMINK in industrial application pilots;
In order to achieve the above mentioned innovation objectives, a feasibility study is needed:
1. to carry out an extensive market analysis and validation study allowing to clearly identify and quantify main market segments, also defining main market drivers, customers desiderata and go to market strategy.
2. To define an industrial development plan aiming at setting up the requirements for a pilot plant that will simulate the reproducibility of the BIOCERAMINK product at commercial scale. The technological roadmap will drive DEF in completing the BIOCERAMINK development, according to result of market study and market validation activities.";71429;50000;H2020-SMEINST-1-2014;SME-1;DEF DI R. DONI S.P.A.;IT;;; 194660;650458;TripOD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Advanced Analytics for Trip Origin-Destination Matrices;1/09/2014;28/02/2015;;"The planning and management of transport systems requires accurate, reliable and updated travel demand information, including travellers socio-economic profile, origin and destination of the trips, trip purpose, transport modes and route choice. Traditional data collection methods, such as household travel surveys, are expensive and require months or even years to complete. TripOD is an innovative solution developed by Nommon that mines and analyses a variety of ICT-based data sources (e.g., mobile phone records, smart cards), alone or in combination with traditional data (e.g., census, traffic counts), to provide frequently updated and rich demographic and travel demand information in a fraction of the time and cost required by traditional methods.
The targeted users are those stakeholders in need of travel demand data, including public authorities and agencies in charge of transport planning and management, public and private transport operators and service providers (e.g., toll road concessionaires), consultants and researchers. Altogether, these users constitute a market of significant size, which is expected to grow continuously along the coming decades due to the increasing awareness about the importance of sustainable and efficient transport systems and the cost-efficiency of the TripOD solution, which makes it affordable for public bodies and companies of any size.
The overall goal of the feasibility study is to assess the technological and economic viability of the proposed concept and elaborate a detailed business plan. The specific objectives are:
- to evaluate the technical feasibility of the solution in operational conditions;
- to provide an in-depth analysis of the market at worldwide level, including users and their needs, competitors and entry barriers, data providers, stakeholders and potential alliances;
- to evaluate financial feasibility;
- to design a strategy to protect intellectual property rights;
- to identify risks and opportunities.";71429;50000;H2020-SMEINST-1-2014;SME-1;NOMMON SOLUTIONS AND TECHNOLOGIES SL;ES;;; 194645;650082;EO-FARM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;EARTH OBSERVATION FARMING;1/10/2014;31/03/2015;;"EOFARM project will cover the topic of Precision Farming (PF), one of the main applications of Earth Observation in the agriculture industry; it makes use of satellite images to help farmers in monitoring and managing crops from planting to harvesting. One of the main needs of farmers, in particular smaller ones which account for 80% of the UAA in EU27, is the possibility to increase yields while reducing the costs and environmental impacts of current crop production processes.
EOFARM main objective is to launch in the market an innovative PF service which targets small farms (average size between 5-30ha), addressing a clear user need, and to enter in the emerging market of commercial applications of EO downstream services in agriculture, estimated to be worth approximately 43 million in 2015.
EOFARM will be based on:
-an innovative algorithm able to integrate the algorithm indexes derived from NDVI(Normalized Difference Vegetation Index), LAI (LEAF AREA INDEX) and OSAVI (Optimized Soil-Adjusted Vegetation Index) for the production of 3 different kind of maps at the same time: crop vigor maps, vegetation status maps, green leaf maps,
- free satellite data derived from the constellation Copernicus (sentinel 2) and Landsat 8
- Open Geo, an open source solution
The impact on the EU Market of agriculture will be huge, considering that the current market for commercial applications of EO downstream services in agriculture is about 34 million and the estimated EO downstream services Total Addressable Market (TAM) for the Agriculture sector amounts to approximately 0,4 billion.
In this context The EOFARM project is expected to boost IPTSAT growth in terms of turnover, EBIDTA and employment opportunity.
Additionally EOFARM will have positive impacts on the small farmers by increasing productivity and sustainability by means of improved resource efficiency: it will possible to use less water, energy, fertilisers (especially phosphorus and nitrogen) and pesticides.";71429;50000;H2020-SMEINST-1-2014;SME-1;IPTSAT SRL;IT;;; 194709;651137;GLAD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;GNSS/INS Low-Cost Attitude Determination System;1/10/2014;31/03/2015;;"The objective of GLAD Phase 1 is the study of the commercial feasibility of a low-cost attitude determination and navigation system based on non-dedicated mass market GNSS receivers and antennas aided by MEMS sensors.
The fusion of GNSS and inertial data takes advantage of the complementarity of these two technologies to achieve accurate and reliable navigation: inertial sensors provide excellent dynamic response at very high data rates, while GNSS serves as an absolute reference to prevent the drift inherent to the numerical integration of acceleration to calculate velocity and position. In addition, differential GNSS carrier-phase measurements can be used to obtain extremely accurate orientation by using a multi-antenna configuration.
This novel navigation system brings the advantages of multi-antenna GNSS systems to applications where these would not be usable otherwise by proposing a cost-effective implementation with competitive performance, size and power, relying on non-dedicated receivers and compensated inexpensive sensors.
The technical feasibility of this approach has already been successfully proven with the fabrication and test of a complete low-cost hardware prototype in a previous R&D project funded by the FP7 programme. The accuracy of the navigation solution using novel algorithms was demonstrated integrating data recorded with this hardware platform, while the computational complexity of a real-time implementation of said algorithms was shown to be suitable for the targeted embedded microcontroller.
A preliminary study of its commercial feasibility was already drafted within this project as well; the objective of this proposal is now to perform a proper commercial feasibility analysis and business plan to guide the path from the prototype demonstrator to mass production of a fully-capable navigation system making use of GPS, Galileo and EGNOS.";71429;50000;H2020-SMEINST-1-2014;SME-1;ACORDE TECHNOLOGIES S.A.;ES;;; 194714;651185;TISSUE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Tissue In Stroke Stratification Using e-ASPECTSTW;1/10/2014;31/03/2015;;"Stroke is a burden with far reaching socioeconomic impact. The only approved treatment in ischaemic stroke is intravenous thrombolysis, which is restricted to 4.5 hours after symptom onset and currently, only 20% of all stroke cases are eligible to receive it. An additional 25% remain untreated because they arrive at the hospital with unknown time of onset.

The objective of the Tissue In Stroke Stratification Using e-ASPECTSTW (TISSUE) proposal is to clinically validate the ASPECTS method and its automated version, the medical device software e-ASPECTSTW, as an imaging biomarker on Non-Contrast Computed Tomography (NCCT) brain scans for identifying ischaemic stroke patients with unknown time of onset who can benefit from thrombolysis.

e-ASPECTSTW addresses the growing worldwide market of 3,250,000 patients (275,000 patients in Europe) every year having a stroke with unknown time of onset. The annual global market size of e-ASPECTSTW is 325,000,000 Euros. Users of e-ASPECTSTW will be hospitals worldwide that provide acute stroke treatment. e-ASPECTSTW will be integrated in existing clinical pathways offering a standardised, fast, reliable and easily accessible assessment of NCCTs. This will increase the uptake of thrombolysis and provide significant economic benefits to hospitals and the health system.
The commercial exploitation of the project results will enhance the growth of Brainomix Ltd leading to increased revenues, profits, employment and will position Brainomix as leaders in imaging biomarkers for neurological and cerebrovascular disorders.

The output of the feasibility study will be a full business plan, including an analysis of the European and global stroke market, an analysis of direct, indirect and potential competition; a detailed business model and pricing strategy as well as financial projections and a detailed design and budget of the prospective multi-centre clinical trial including the participating stroke units.";71429;50000;H2020-SMEINST-1-2014;SME-1;BRAINOMIX LIMITED;UK;;; 194805;652654;OK-Net Arable;SIGNED;H2020-EU.3.2.;ISIB-02-2014;H2020;Organic Knowledge Network Arable;1/03/2015;28/02/2018;;"The overall aim of the thematic network OK-Net Arable is to improve the exchange of innovative and traditional knowledge among farmers, farm advisers and scientists to increase productivity and quality in organic arable cropping all over Europe, in order to satisfy future market demand.

To achieve this, 'OK-Net Arable' has three specific objectives:
1) to create a European network of well-functioning farmer innovation groups representing the best examples of co-innovation by farmers and researchers. The network of farmer innovation groups will serve to exchange experiences in the area of arable crop production and test the innovative end-user and education material developed in the project;
2) to digest and synthesize the considerable knowledge available from the reservoir of scientific and practical knowledge in the area of organic arable farming and to identify the best methodology in learning and knowledge exchange. Based on this easily understandable education and end-user material will be developed;
3) to create a platform for knowledge exchange across Europe unique in organic farming, offering both innovative education and end-user material as well as offering opportunities for farmer-to-farmer, advisor-to-advisor or researcher-to-advisor-to-farmer learning.

The multi-actor approach is prominent in this proposal: (1) at EU level with scientific partners and farmers' associations jointly coordinating the work packages; (2) on the local level with farmers, farm advisors and scientists cooperating in farmer innovation groups. The whole consortium covers in total 13 countries from all corners of Europe giving a well-balanced representation of different climate, geographical and socio-economic conditions.";2185377,5;1936627,5;H2020-ISIB-2014-1;CSA;INTERNATIONAL FEDERATION OF ORGANIC AGRICULTURE MOVEMENTS EUROPEAN UNION REGIONAL GROUP;SE;"EESTI MAHEPOLLUMAJANDUSE SIHTASUTUS;CONSORZIO MARCHE BIOLOGICHE - SOCIETA COOPERATIVA AGRICOLA;OKOLOGIAI MEZOGAZDASAGI KUTATOINTEZET KOZHASZNU NONPROFIT KFT;EIROPAS LAUKSAIMNIECIBAS UN LAUKU KONSULTANTU ASOCIACIJA;CENTRO INTERNAZIONALE DI ALTISTUDI AGRONOMICI MEDITERRANEI;INSTITUT TECHNIQUE DE L AGRICULTURE BIOLOGIQUE;AARHUS UNIVERSITET;FONDATSIYA ZA BIOLOGICHNO ZEMEDELIE BIOSELENA;FORSCHUNGSINSTITUT FUR BIOLOGISCHENLANDBAU OSTERREICH, ABGEKURZT FIBLOSTERREICH;BIOLAND BERATUNG GMBH;FORSCHUNGSINSTITUT FUR BIOLOGISCHENLANDBAU STIFTUNG;ASSOCIAZIONE ITALIANA PER L AGRICOLTURA BIOLOGICA*AIAB;BIOFORUM VLAANDEREN;FIBL PROJEKTE GMBH;PROGRESSIVE FARMING TRUST LTD LBG;SEGES PS";"EE;IT;HU;LV;FR;DK;BG;AT;DE;CH;BE;UK"; 194626;649849;ENTROPY;SIGNED;H2020-EU.3.3.1.;EE-11-2014;H2020;DESIGN OF AN INNOVATIVE ENERGY-AWARE IT ECOSYSTEM FOR MOTIVATING BEHAVIOURAL CHANGES TOWARDS THE ADOPTION OF ENERGY EFFICIENT LIFESTYLES;1/09/2015;31/08/2018;;"Taking into account the fact that buildings constitute the largest end-use energy consuming sector, the design and development of solutions targeted at reducing their energy consumption based on the adoption of energy efficient techniques and the active engagement of citizens/occupants is considered crucial. Innovative solutions have to be implemented upon properly understanding the main energy consuming factors and trends, as well as properly modeling and understanding the citizens behaviour and the potential for lifestyle changes.
The ENTROPY project addresses this challenge by building upon the integration of technologies that facilitate the deployment of innovative energy aware IT ecosystems for motivating end-users behavioural changes and namely: (1) the Internet of Things that provides the capacity for interconnecting numerous devices and applying energy-efficient communication protocols, (2) the evolvement of advanced Data Modelling and Analysis techniques that support the realization of semantic models and knowledge extraction mechanisms and (3) the Recommendation and Gamification eras that can trigger interaction with relevant users in social networks, increase end users awareness with regards to ways to achieve energy consumption savings in their daily activities and adopt energy efficient lifestyles as well as provide a set of energy efficient recommendations and motives.
Novel practices that fully integrate information collected from a set of sensor networks and mobile crowd sensing activities are going to be exploited along with processes for monitoring, reporting and analysing sets of data with regards to energy consumption and the behavioural profile of citizens. The engagement and inclusion of end users will be strongly supported upon the development of a set of serious games and personalised applications.
The designed IT ecosystem is planned to be validated in three pilot sites.";2439467,5;1997592,5;H2020-EE-2014-2-RIA;RIA;UNIVERSIDAD DE MURCIA;ES;"DRUSTVO ZA KONSALTING, RAZVOJ I IMPLEMENTACIJU INFORMACIONIH I KOMUNIKACIONIH TEHNOLOGIJA DUNAVNET DOO;GIOUMPITEK MELETI SCHEDIASMOS YLOPOIISI KAI POLISI ERGON PLIROFORIKIS ETAIREIA PERIORISMENIS EFTHYNIS;HYPERBOREA SRL;Polo Navacchio S.p.A.;HAUTE ECOLE SPECIALISEE DE SUISSE OCCIDENTALE;INTELEN SERVICES LIMITED;UNIVERSITAET INNSBRUCK;ATHENS UNIVERSITY OF ECONOMICS AND BUSINESS - RESEARCH CENTER";"RS;EL;IT;CH;CY;AT"; 194556;649082;BAS-SBBT;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Bacterial Amyloid Secretion: Structural Biology and Biotechnology.;1/06/2015;31/05/2020;;"Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria. Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimers and Parkinsons disease, curli are the product of a dedicated protein secretion machinery. Curli formation requires a specialised and mechanistically unique transporter in the bacterial outer membrane, as well as two soluble accessory proteins thought to facilitate the safe guidance of the curli subunits across the periplasm and to coordinate their self-assembly at cell surface.

In this interdisciplinary research program we will study the structural and molecular biology of E. coli curli biosynthesis and address the fundamental questions concerning the molecular processes that allow the spatially and temporally controlled transport and deposition of these pro-amyloidogenic polypeptides. We will structurally unravel the secretion machinery, trap and analyse critical secretion intermediates and through in vitro reconstitution, assemble a minimal, self-sufficient peptide transport and fiber assembly system.

The new insights gained will set the stage for targeted interventions in curli -mediated biofilm formation and this research project will develop a new framework to harness the unique properties found in curli structure and biosynthesis for biotechnological applications as in patterned functionalized nanowires and directed, selective peptide carriers.";1989488,75;1989488,75;ERC-2014-CoG;ERC-COG;VIB;BE;;; 194606;649717;RESFARM;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Developing and implementing financial instruments for the mobilisation of investments in renewable energy in the agrarian sector;1/03/2015;31/12/2017;;On-farm Renewable Energy Systems (RES) can provide agrarian communities with an extra source of stable income, while guaranteeing long term clean energy supply for society. Despite their enormous potential for RES, in practice many farmers are not capable of accessing the financial, technical and administrative resources required for installing RES capacity on their farms. This is caused by RES investments generally being restricted to project finance for large installations while RES types that can be installed on farms require bank loans. This limitation greatly restricts capital supply while raising overall cost. Most farms in the targeted countries have a low credit profile that disqualifies them for loans. To overcome this limitation and fully take advantage of the last few years cost reductions and performance advancements in RES, a tailored investment instrument is needed that can attract capital from capital markets and especially from institutional investors to on-farm RES. The recent appearance of innovative investment schemes, addressed to overcome similar challenges in other sectors, demonstrates that, by creating pools of RES, access to capital market resources can be realized. The proposed action is designed to initiate a structured dialogue among farmers, financiers and other relevant experts and stakeholders in order to develop and promote such an investment instrument, tailored for on-farm RES. The consortium that presents this proposal includes, among other key stakeholders, a leading European financial institution, a university as well as the largest farmers associations of Spain, Italy and Greece. The quality of the consortium and the relevance of the expected results mean that this proposal is a unique opportunity to increase the financeability of on-farm RES in Europe.;1625250;1625245;H2020-EE-2014-3-MarketUptake;CSA;UNIONS AGRARIAS UPA;ES;"ELA, INGENIERIA Y MEDIO AMBIENTE SL;BANCO DE SABADELL;INSTITUTO ENERGETICO DE GALICIA - INEGA - INSTITUTO ENERXETICO DE GALICIA;UNION DE COOPERATIVAS ASOCIACION GALEGA DE COOPERATIVAS AGRARIAS;UNIVERSIDADE DA CORUNA;ASOCIACION AGRARIA JOVENES AGRICULTORES-ASAJA GALICIA;SINDICATO LABREGO GALEGO - COMISIONS LABREGAS;AGRICOLTURA E VITA - ASSOCIAZIONE;BIOMASS RESEARCH BV;PANHELLENIC CONFEDERATION OF UNIONS OF AGRICULTURAL COOPERATIVES SOMATEIO;RESEARCH4LIFE B.V.";"ES;IT;NL;EL"; 194567;649263;MOVE;SIGNED;H2020-EU.3.6.;YOUNG-2-2014;H2020;Mapping mobility pathways, institutions and structural effects of youth mobility in Europe;1/05/2015;30/04/2018;;"The overall ambition of MOVE is to provide a research-informed contribution towards an improvement of the conditions of the mobility of young people in Europe and a reduction of the negative impacts of mobility through the identification of ways of good practice thus fostering sustainable development and wellbeing. The consortium of MOVE is built up of nine partners within six countries: Luxembourg, Germany, Hungary, Norway, Romania and Spain.

The main research question is: How can the mobility of young people be good both for socio-economic development and for individual development of young people, and what are the factors that foster/hinder such beneficial mobility?
Based on an interdisciplinary and multilevel research approach the main objectives of MOVE are to:
[1] carry out a comprehensive analysis of the phenomenon of mobility of young people in the EU;
[2] generate systematic data about young peoples mobility patterns in Europe based on qualitative case studies, a mobility survey and on secondary data analysis;
[3] provide a quantitative integrated database on European youth mobility;
[4] offer a data based theoretical framework in which mobility can be reflected, thus contributing to the scientific and political debates.
[5] explore factors that foster and factors that hinder good practice based on an integrative approach with qualitative and quantitative evidence.
[6] provide evidence-based knowledge and recommendations for policy makers through the development of good-practice models.

MOVE is based on a multilevel research design, including case studies on six types of mobility (higher education, voluntary work, employment, vocational training, pupil's exchange and entrepreneurship), a survey (N=6400) and secondary data analysis, taking into consideration social inequality (e.g. migration background, gender, educational inequalities, impairments). The focus will be on the regional contexts of mobility and the agency of young people.";2499910;2499910;H2020-YOUNG-SOCIETY-2014;RIA;UNIVERSITE DU LUXEMBOURG;LU;"EUROPEAN RESEARCH AND PROJECT OFFICE GMBH;STIFTUNG UNIVERSITAT HILDESHEIM;DEUTSCHES JUGENDINSTITUT EV;HOGSKULEN I SOGN OG FJORDANE;ILUSTRE COLEGIO NACIONAL DE DOCTORES Y LICENCIADOS EN CIENCIAS POLITICAS Y SOCIOLOGIA;MISKOLCI EGYETEM;AGENCE EUROPEENNE POUR L'INFORMATION ET LE CONSEIL DES JEUNES ASBL;ACADEMIA DE STUDII ECONOMICE DIN BUCURESTI";"DE;NO;ES;HU;LU;RO"; 194541;648551;GRANN;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Graphene Coated Nanoparticles and Nanograins;1/07/2015;30/06/2020;;"In a truly cross-disciplinary research project encompassing surface science, optics, nano-science, astrophysics and chemistry we will synthesize a novel family of high quality mono-layer graphene coated nanoparticles and graphene nanograins with new chemical and optical properties and investigate their catalytic activity, chemical stability and optical characteristics to gauge their relevance for and applicability in industrial catalysis, solar cells, and interstellar chemistry.

This will be accomplished by extending existing expertise, knowledge and methods developed by us and by international colleagues for graphene synthesis, graphene reactivity and chemical functionalization, graphene coatings on industrially relevant samples and interstellar surface astrochemistry on carbonaceous materials, into the nanoparticle regime. Combined with state-of-the-art surface science characterization methods with emphasis on scanning tunnelling microscopy and spectroscopy, high resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and thermal desorption mass spectrometry, complemented by Raman and transmission spectroscopy, this will enable us to design, characterize, and understand the properties of this new family of particles at the atomic level.

The vision is to harness and combine the remarkable properties of graphene and nanoparticles to create systems with entirely new and unexplored characteristics, to tune these characteristics to be useful for real-world applications, and to exploit the new systems as the first realistic laboratory models of catalytic nanoparticles for interstellar surface chemistry.

This ambitious and cross-disciplinary research program will predominantly take place at the Surface Dynamics Laboratory at Aarhus University which is headed by the applicant, but will also involve local, national and international collaborators.";1996147;1996147;ERC-2014-CoG;ERC-COG;AARHUS UNIVERSITET;DK;;; 194630;649875;BRISKEE;SIGNED;H2020-EU.3.3.6.;EE-12-2014;H2020;Behavioural Response to Investment Risks in Energy Efficiency;1/03/2015;31/08/2017;;"Investments in energy efficiency in the residential sector (27% of EU final energy demand) may also provide economic benefits at different levels of the economy. These benefits may not be realized because of barriers, which are typically reflected in implied discount rates. BRISKEE (Behavioural Response to Investment Risks in Energy Efficiency) provides evidence-based input to energy efficiency policy design and evaluation, thereby supporting the market uptake of energy efficiency technologies in the EU residential sector. It contributes to the work programme by addressing the interrelations between microeconomic factors, sectoral energy demand and macroeconomic effects, relying on a consistent methodological framework implemented in 5 work packages:
Provide empirical evidence for the magnitudes of discount rates accounting for differences across households, technologies and countries, and assess their effects on the diffusion of efficiency technologies in the EU (micro-level). A multi-country survey (1000 interviews per country) will be carried out and analyzed econometrically.
Explore the impact of time discounting and risk preferences (and of policies affecting those factors) on the diffusion of energy efficient technology and energy demand in the EU residential sector until 2030 (meso-level). Established bottom-up vintage stock models will be employed for appliances (FORECAST-Residential) and for buildings (Invert/EE-Lab).
Explore the macro-level impacts of changes in microeconomic decision-making and of energy efficiency policy on employment, GDP and exports in the EU until 2030. This involves simulations with an established macro-economic model for the EU (ASTRA).
Provide evidence-based recommendations for key energy efficiency policies and input for impact assessments and policy analysis at the three levels of analysis.
Communicate and disseminate empirical findings to policy makers, national experts, the research community and the general public.";1029133,25;1029133,25;H2020-EE-2014-2-RIA;RIA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"TECHNISCHE UNIVERSITAET WIEN;EUROPEAN COUNCIL FOR AN ENERGY EFFICIENT ECONOMY FORENING - ECEEE;Chambre de Commerce et d'Industrie de Grenoble;CARDIFF UNIVERSITY";"AT;SE;FR;UK"; 194791;652474;PICOMB;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Photonic Integrated Comb Source: An Economic Feasibility Study;1/10/2014;31/03/2015;;"Optical telecommunication networks are being put under huge strain by the rise in mobile video, video-on-demand and other bandwidth intensive services. New disruptive innovations are needed to avoid the impending 'capacity crunch' that that has the potential to affect the growth of the Internet with knock-on adverse effects for the European and global economy and society.

Optical Frequency Comb Sources represent one such disruptive innovation. Optical Frequency Combs allow new modulation techniques to be used that increase the data carrying capacity and spectral efficiency of these networks.

The benefits of Optical Frequency Combs are well known, but to date no-one has figured out a cost-efficient means to employ them in network equipment. Pilot Photonics Ltd., an Irish SME has licensed a suite of intellectual property around Optical Frequency Combs that has the potential to disrupt the market and displace the single mode lasers that have been used in long haul optical transport equipment for two decades.

The intellectual property offers two capabilities: The cost-effective generation of a suitable optical comb, and the cost-efficient demultiplexing of that optical comb for modulation. Both techniques are suitable for photonic integration and can be fabricated using foundry compatible processes, enhancing their viability greatly. The comb generation technique is currently being marketed in bench-top form factor, while integrated prototypes have been produced. The demultiplexing concept has been proven in both bench-top experiments and in photonic integrated circuits. The innovation is in their combination to create value beyond the sum of the parts.

The PICOMB project will examine the economic feasibility of this disruptive innovation, through detailed interaction with potential customers and partners. The outputs will be a detailed market survey, desired customer specifications, and cost model which will be combined into a comprehensive business plan.";71429;50000;H2020-SMEINST-1-2014;SME-1;PILOT PHOTONICS LTD;IE;;; 194611;649647;TOPTEN ACT;SIGNED;H2020-EU.3.3.7.;EE-10-2014;H2020;Enabling consumer action towards top energy-efficient products;1/03/2015;28/02/2018;;"TOPTEN ACT aims at empowering consumers to ACT: to purchase top energy-efficient products that will save energy over their lifetime.

TOPTEN ACT develops a comprehensive market transformation strategy targeting consumers, manufacturers, retailers, large buyers, consumer associations and other key actors in 16 European countries, covering a combined population of 447 Mio inhabitants. It works with these actors to help them embrace and promote energy-efficient products, so that they become the natural choice for consumers. Project partners will:
- Manage 16 Topten websites presenting up-to-date, consumer-oriented information to 2 Mio visitors per year. These websites will showcase top energy-efficient models in a number of product groups: domestic appliances, cooling and lighting equipment, consumer electronics, vehicles etc. They build on independent and reliable market surveys selecting the best available technologies (BATs) amongst hundreds of thousands of products. ? Consumers identify top products, compare costs and understand the benefits of energy performance on their electricity bills and for the environment.
- Push this information to consumers through extensive use of the media, communications and partnerships with key organisations acting as multipliers. ? Impartial information reaches consumers.
- Work with retailers, leveraging on their unique market position, directly in contact with consumers about to ACT, to further increase purchases of energy-efficient product. ? In just one click, consumers will find and buy top efficient products.

TOPTEN ACT impacts are both quantitative savings of 331 GWh/year triggered per million invested and qualitative: markets are more transparent, media report on top efficient products, multipliers relay the Topten message to their target groups, consumers change their using and purchasing behaviour, retailers change their range and highlight BAT products, manufacturers shift their production lines.";1933671,5;1793866,5;H2020-EE-2014-3-MarketUptake;CSA;AGENCE DE L'ENVIRONNEMENT ET DE LA MAITRISE DE L'ENERGIE;FR;"SEVEN STREDISKO PRO EFEKTIVNI VYUZIVANI ENERGIE O.P.S.;ASOCIACION PARA LA DEFENSA DE LA NATURALEZA;NORGES NATURVERNFORBUND;OEKO-INSTITUT E.V. - INSTITUT FUER ANGEWANDTE OEKOLOGIE;LIETUVOS NACIONALINE VARTOTOJU FEDERACIJA ASOCIACIJA;FUNDACJA NA RZECZ EFEKTYWNEGO WYKORZYSTANIA ENERGII;SOCIETA COOPERATIVA SOCIALE ELIANTE ONLUS;GUIDE TOPTEN SARL;SVENSKA NATURSKYDDSFORENINGEN I;THE ENERGY SAVING TRUST LIMITED;OSTERREICHISCHE ENERGIEAGENTUR AUSTRIAN ENERGY AGENCY;BOND BETER LEEFMILIEU VLAANDEREN;INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ENERGIE ICEMENERG-BUCURESTI;OEKOZENTER PAFENDALL ASBL;Quercus - Associao nacional de Conservao da natureza;BUSH ENERGIE GMBH";"CZ;ES;NO;DE;LT;PL;IT;FR;SE;UK;AT;BE;RO;LU;PT;CH"; 194700;651054;BEVSTREAM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;High Pressure Processing (HPP) equipment for large beverage productions;1/11/2014;30/04/2015;;"Hiperbaric is an SME leader in designing, manufacturing and commercializing High Pressure Processing (HPP) machines on an industrial scale. HPP is an innovative processing technology for many types of food (meat, seafood, vegetable, fruit products) with an important growing potential over the traditional techniques such as thermal pasteurization. This process inactivates food microorganisms, increasing safety and shelf-life, keeping flavor, nutrients and product freshness.

HPP is currently a batch post-packaging process and this fact limits its productivity as the packaged/bottled product takes up more room of allowable vessel volume. This low productivity prevents the development of HPP in some important markets such as the beverage market (650 million tons in 2012).

The final objective of the Bevstream project is to commercialize the first semi-continuous HPP equipment for large productions of beverages or liquid food, reaching a 2% beverage global market penetration in 2026 (200 machines). Hiperbaric proposes a breakthrough concept for liquid processing, changing the approach from a batch post-packaging process to a semi-continuous prepackaging process. This will be achieved by scaling-up a Hiperbaric prototype to industrial large scale machine able to process liquid food directly into the vessel. This concept will mean increasing HPP productivity, lowering processing cost, and energy consumption and easing the installation within beverage production lines.
The expected market for Hiperbaric is 40 machines in the 5 years following SME Instrument Phase 2 project. This new business line will suppose more than 50% of Hiperbaric turnover in 2021 and a 40% staff increase.

The proposed feasibility assessment will evaluate this new concept by measuring market size, defining an IPR strategy and determining product technical and economic feasibility. The results will determine how the project could be developed in SME Instrument Phase 2.";71429;50000;H2020-SMEINST-1-2014;SME-1;HIPERBARIC SA;ES;;; 194554;649008;QLev4G;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Quantum control of levitated massive mechanical systems: a new approach for gravitational quantum physics;1/06/2015;31/05/2020;;"Quantum physics and general relativity are probably the most successful and well-tested theories of modern science. At the same time, their fundamental concepts are so dramatically different that there is disagreement on the most obvious questions such as how does a mass in a quantum superposition state gravitate?. Achieving progress on such foundational questions requires experiments at the interface between quantum physics and gravity, of which to date only a few of exist. The main objective of the proposed research is to establish quantum control of levitated massive objects as a new paradigm system for such experiments and to enter a hitherto inaccessible parameter regime of large mass and long quantum coherence.

The proposal builds on the enormous recent success in quantum control of the motion of solid-state mechanical resonators, which has emerged over the last decade as a new branch of interdisciplinary research in quantum and solid-state physics. Applied to optically or magnetically levitated systems this methodology promises (i) exceptional sensitivity to weak gravitational forces, hence enabling measurements of gravity between sub-millimeter objects; (ii) unprecedented levels of decoupling from the environment, thereby opening up a new route for long-lived quantum coherence of genuinely massive systems. Quantum control is achieved by coupling the motion either of optically trapped particles to an optical cavity field or of magnetically trapped particles to superconducting circuits. We will explore both methods for systematically expanding the available parameter space of macroscopic quantum systems and for first proof-of-concept experiments aimed towards addressing fundamental questions of gravitational quantum physics.

If successful, this research program will become a door-opener to the quantum regime of genuinely massive objects, where gravity of the quantum system itself may start to play a role for the correct description of a quantum experiment.";2155285;2155285;ERC-2014-CoG;ERC-COG;UNIVERSITAT WIEN;AT;;; 194694;650913;FFI;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Forward Flow Infusion - Low Cost Composite Manufacturing Process for High Volume Production;1/11/2014;30/04/2015;;"Fibre reinforced polymer composites are used in many markets including industrial mouldings, marine, wind energy and aerospace. They are produced by embedding load-bearing fibres into a thermosetting or thermoplastic resin matrix. Depending on the choice of fibre, resin and their physical structure, a wide range of properties can be obtained and in large part this explains their widespread use.

Available manufacturing processes include hand or spray layup, resin transfer moulding (RTM), compression moulding, vacuum infusion and the use of pre-impregnated materials, which are normally consolidated in pressurised autoclaves. The choice of fibre, fabric and matrix materials influence processing requirements, so that selecting a manufacturing process is a complex decision taking into account material properties, cost, quality, capital expenditure and the number of parts to be manufactured.

Composite manufacturing processes are slow, labour intensive and consequently costly. For example, RTM requires high capital investment for tooling and resin injection equipment. Prepreg materials are expensive to purchase and the cost of autoclaves is only justified for high value applications. Vacuum infusion is slow with ongoing consumable costs. Although the use of composites has increased in aerospace and wind energy markets, high manufacturing costs continue to hold back composites growth, particularly in high volume markets.

Forward Composites has a solution to the above issues. We have demonstrated a new process where infusion time can be reduced by over 80% and materials costs can be reduced by up to 75% compared to prepregs. Once fully commercialised, labour savings will be realised through automation and cure times will be reduced using localised heating and cooling solutions. Initially, we plan to exploit opportunities in automotive chassis manufacture. Longer term, we will expand our use of the process and license the technology to other composites manufacturers.";71429;50000;H2020-SMEINST-1-2014;SME-1;FORWARD COMPOSITES LIMITED;UK;;; 194637;649972;EURECA;SIGNED;H2020-EU.3.3.7.;EE-08-2014;H2020;Datacenter EURECA Project;1/03/2015;31/08/2017;;The EURECA project tackles the lack of knowledge and awareness of how to identify and procure environmentally sound and greener data centres. The work will encompass solutions for pre-commercial procurement (PCP) and procurement of innovative solutions (PPI). This will be achieved by consolidating recognised and emerging benchmark criteria into an easy-to-use tool that can be deployed by non-experts. EURECA will recommend an improvement roadmap indicating the procurement options(s) to reduce energy consumption, make efficiencies and minimise the environmental footprint. Key criteria will be presenting the Cost-Benefit analysis, covering the life cycle of the datacentre and the environmental impact. The project will strengthen business cases by presenting training and advisory resources on how to establish the options with both technical and commercially neutral information, without prejudice. These options include, as appropriate, to perform detailed studies on investing in existing staff, refitting facilities, consolidation actions, new builds, or outsourcing or specific combinations or subsets of these. The resources include RFI, ITT or RFP templates, technical & environmental data directories and a case study catalogue, structured along the procurement workflow. The ultimate goal is to enable procurement teams to choose environmentally sound buying options whilst producing true and robust cost-benefit visibility to enable successful triggering of tenders. To ensure efficient use of the projects developments, we will deliver a coherent set of targeted and efficient training components, developed throughout the project that supports the use of the EURECA tool and its resources. The consortiums existing comprehensive liaisons to European and international standards committees and industry groups will ensure the EURECA programme is a living resource that is sustainable, interactive and able to reflect the latest developments.;1534055,5;1534055,5;H2020-EE-2014-3-MarketUptake;CSA;UNIVERSITY OF EAST LONDON;UK;"NORLAND MANAGED SERVICES (IRELAND) LIMITED;TELECITYGROUP GERMANY GMBH;WOLF MARC-ANDREE;CARBON3IT LTD;STICHTING GREEN IT CONSORTIUM REGIO AMSTERDAM;DATA CENTRE ALLIANCE LIMITED;MAKI CONSULTING GMBH;CERTIOS BV";"IE;DE;UK;NL"; 194526;648179;ConTExt;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Connecting the Extreme;1/09/2015;31/08/2020;;Advances in technology and methodology over the last decade, have enabled the study of galaxies to the highest redshifts. This has revolutionized our understanding of the origin and evolution of galaxies. I have played a central role in this revolution, by discovering that at z=2, when the universe was only 3 Gyr old, half of the most massive galaxies were extremely compact and had already completed their star formation. During the last five years I have led a successful group of postdocs and students dedicated to investigating the extreme properties of these galaxies and place them into cosmological context. Combining a series of high profile observational studies published by my group and others, I recently proposed an evolutionary sequence that ties together the most extreme galaxies in the universe, from the most intense dusty starburst at cosmic dawn, through quasars: the brightest sources in the universe, driven by feedback from supermassive black holes, and galaxy cores hosting the densest conglomerations of stellar mass known, to the sleeping giants of the local universe, the giant ellipticals. The proposed research program will explore if such an evolutionary sequence exists, with the ultimate goal of reaching, for the first time, a coherent physical understanding of how the most massive galaxies in the universe formed. While there is a chance the rigorous tests may ultimately reveal the proposed sequence to be too simplistic, a guarantied outcome of the program is a significantly improved understanding of the physical mechanisms that shape galaxies and drive their star formation and quenching;1999526;1999526;ERC-2014-CoG;ERC-COG;KOBENHAVNS UNIVERSITET;DK;;; 194615;649753;OrbEEt;SIGNED;H2020-EU.3.3.1.;EE-11-2014;H2020;ORganizational Behaviour improvement for Energy Efficient adminisTrative public offices;1/03/2015;28/02/2018;;"Tertiary sector buildings sector consume a sizeable proportion of EU total energy consumption and the majority of consumption is directly attributed to the operational phase of the building life-cycle. Occupant behaviour is a major cause of this consumption. OrbEEt proposes an ICT-based framework to induce behaviour change toward energy efficiency by transforming energy measurements into personalized feedback delivered through engaging user interfaces.
To achieve this challenge, OrbEEt foresees dynamic, spatially fine-grained extensions of building-level Operational Rating methodologies and Display Energy Certificates to provide a detailed view of energy use in office spaces, business processes and organizational entities rather than entire buildings. The fusion of information from Building Information Models, Business Process Models and real-time energy use measurement via a comprehensive ICT cloud service - the Systemic Enterprise Operational Rating framework - will enable energy use tracking and will establish direct accountability of people, processes and spaces toward overall consumption.
Exposing the direct influence of occupant behaviour on energy use enables the design and successful deployment of behavioural change campaigns in public organization buildings. OrbEEt proposes interventions appealing to intrinsic/extrinsic human motivators through intra-organization social competitions and organization-wide social collaboration endeavours.
The OrbEEt framework and behavioural change interventions will undergo real-life pilot validation in four EU public buildings that provide the business, cultural and geographical diversity for demonstration of result effectiveness and transferability.
Finally, the OrbEEt consortium will use a User Driven Innovation Approach throughout its development, deployment and validation of phases to leverage and actively support Open Innovation and the EU Cleanweb/start-up community toward further exploitation of its outcomes.";1776625;1776625;H2020-EE-2014-2-RIA;RIA;SOLINTEL M&P SL;ES;"COVENTRY UNIVERSITY;BUNDESMINISTERIUM FR FAMILIEN UND JUGEND;UNIVERSITATSKLINIKUM ERLANGEN;GRINDROP LTD;HYPERTECH (CHAIPERTEK) ANONYMOS VIOMICHANIKI EMPORIKI ETAIREIA PLIROFORIKIS KAI NEON TECHNOLOGION;MUNICIPALITY OF PERNIK;BALKANIKA ENERGY AD;AYUNTAMIENTO DE ASPARRENA;BOC ASSET MANAGEMENT GMBH";"UK;AT;DE;EL;BG;ES"; 194684;650697;PRIME;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;PRIME (Push Relevantly to Increase Mobile Engagement);1/10/2014;31/03/2015;;"'The rapid growth of smartphones and tablets pave the way for proliferation of a variety of mobile applications. Push notifications, which provide enhanced communication when compared to SMS, became the de facto messaging tool between application owners and mobile users. However, push notifications are still sent carelessly which results user frustration, low open rates (10%) and decreased user retention.

PRIME (Push Relevantly to Increase Mobile Engagement) is cloud service which aims to create the next leap in push messaging by gathering various sensory information from mobile devices analyzing big data and providing real-time insights by using machine learning, data mining and home grown pattern matching algorithms. PRIME will anticipate mobile users context, and forecasts their needs from previous usage patterns and dynamic models. PRIME will either send relevant push notification immediately or refer it for a more relevant time in the near future.

PRIME anticipates the prime time of mobile user and send push notifications accordingly. The dynamic model of PRIME is expected to increase open rates of push notifications among smartphone and tablet users tremendously. PRIME has both benefits to mobile users and mobile application owners. Sending push notifications relevantly increases customer retention due to mobile user satisfaction and increases mobile engagement which in turn increases mobile revenues.

The initial research for PRIME has been done by DONE A.S. and funded by TB?TAK (Scientific and Technological Research Council of Turkey). The research findings, which are also published in 'Human Computer Interaction International' 2013 and 2014, demonstrated a 36% user engagement increase and 21% increase in the number of active users. These demonstrated results equal to an impact of 26.62 billion EURO in 2018 globally, whose details are given in the proposal document.'";71429;50000;H2020-SMEINST-1-2014;SME-1;DONE ILETISIM BILGI SISTEMLERI VE YAY. SAN. VE TIC. A.S.;TR;;; 194591;649497;QuInnE;SIGNED;H2020-EU.3.6.;EURO-2-2014;H2020;Quality of Jobs and Innovation Generated Employment Outcomes;1/04/2015;31/03/2018;;"The EU is facing long-term structural challenges compounded by the recent economic crisis. More and better jobs are needed to lower unemployment, raise the employment participation rates of female, older, migrant, low-skilled and young workers and thus tackle social exclusion and inequality. The EUs growth strategy, Europe 2020, wants smart, sustainable and inclusive growth, with innovation and job quality as flagship initiatives. Innovation and job quality are however currently treated separately but ought to be better integrated in policy and workplace practice. Research that can lever this to mutually boost innovation and job quality is needed.
QuInnE contributes to the EU growth strategy of boosting innovation, job quality and employment by exploring the mutually reinforcing relationship between innovation and job quality and identifying mechanisms that can be accelerated to deliver both more and better jobs, which in turn help tackle social exclusion and inequality.
QuInnE creates a new analytical framework of for understanding the relationship between innovation and job quality and that relationships impact on employment. This framework is then used to statistically analyse existing datasets to create a typology of innovation-job quality dynamics by industry and country. The analysis is then extended to assess how different types of relationships create jobs, and provide jobs that are accessible and sustainable for groups of workers currently struggling in the labour market, and reduce social inequalities by age, class and gender. QuInnE then explores how the innovation-job quality dynamic creates more and better jobs at firm level.
There are three main outcomes: new scientific understanding of the innovation-job quality-employment dynamic; new diagnostic and developmental tools to help monitor and measure this dynamic at national level and improve that dynamic in firms and workplaces; evidence-based advice on developing policy to boost EU growth.";2498869;2498869;H2020-EURO-SOCIETY-2014;RIA;LUNDS UNIVERSITET;SE;"MAGYAR TUDOMANYOS AKADEMIA TARSADALOMTUDOMANYI KUTATOKOZPONT;UNIVERSIDAD DE SALAMANCA;MALMOE HOEGSKOLA (MALMOE UNIVERSITY);UNIVERSITAET DUISBURG-ESSEN;THE UNIVERSITY OF WARWICK;ERASMUS UNIVERSITEIT ROTTERDAM;Centre Pour La Recherche Economique Et Ses Applications;UNIVERSITEIT VAN AMSTERDAM";"HU;ES;SE;DE;UK;NL;FR"; 194604;649718;SPP Regions;SIGNED;H2020-EU.3.3.7.;EE-08-2014;H2020;SPP Regions;1/04/2015;31/03/2018;;"The SPP Regions project is aimed at promoting strong networking and collaboration at both the European and sub-national regional level on sustainable and innovative procurement (SPP/PPI), to help promote and embed capacity building and knowledge transfer.

At the regional level networking will be promoted to build capacities and transfer skills in sustainable and innovative procurement implementation, and to collaborate directly on tendering for eco-innovative solutions. New networks will be established, or existing networks strengthened in 7 European regions (Copenhagen, Rotterdam, Torino, Bristol, Barcelona, West France and Gabrovo). Networking activities will include an intensive capacity building programme and collaboration on at least 6 tenders per region - 42 in total.

At the European level a Sustainable Procurement and Innovation Network will be launched, expanding on the existing Procura\ Campaign. In-depth research will be conducted into European best practice relating to a series of key SPP/PPI topics (market engagement, life cycle costing, output/performance-based specifications, circular procurement) by a series of experts in consultation with network participants. A series of European seminars and expert workshops will be organised, together with an ongoing webinar series, and the annual presentation of a PPI award for European best practice.";1492459,63;1492459,13;H2020-EE-2014-3-MarketUptake;CSA;ICLEI EUROPEAN SECRETARIAT GMBH (ICLEI EUROPASEKRETARIAT GMBH)*;DE;"GEMEENTE ROTTERDAM;REGION HOVEDSTADEN;MUNICIPALITY OF GABROVO;CITTA METROPOLITANA DI TORINO;UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL;ASSOCIATION DU RESEAU GRAND OUEST DEVELOPPEMENT DURABLE ET COMMANDE PUBLIQUE;AGENZIA REGIONALE PER LA PROTEZIONE AMBIENTALE DEL PIEMONTE;MUNICIPAL ENERGY EFFICIENCY NETWORKECOENERGY ASSOCIATION;BRISTOL CITY COUNCIL;ECOINSTITUT SCCL S.COOP;DIPUTACION DE BARCELONA;The Danish Environmental Agency";"NL;DK;BG;IT;UK;FR;ES"; 194513;647573;MODEST;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Mathematical Optimization for clinical DEcision Support and Training;1/07/2015;30/06/2020;;"Physicians need to make many important decisions per day. One clinical example is the scheduling and dosage of chemotherapy treatments. A second example is the discrimination of atrial fibrillation from atypical atrial flutter, based on ECG data. Such important and complex decisions are usually based on expert knowledge, accumulated throughout the life of a physician and shaped by subjective (and sometimes unconscious) experience. It is not readily transferable and may be unavailable in rural areas. At the same time, the available imaging, laboratory, and basic clinical data is abundant and waits to be used. This data is not yet systematically integrated and often single data-points are used to make therapy decisions.

More and more clinical decision making tasks will be modeled in terms of mathematical relations.
I propose a systematic approach that supports and trains individual decision making. The developed ideas, mathematical models, and optimization algorithms will be generic and widely applicable in medicine and beyond, but also exploit specific structures, resulting in a patient- and circumstance-specific personalized medicine.

This allows, e.g., a physician to first simulate the impact of his decisions on a computer and to consider optimized solutions.
In the future, it will be the rare and unwanted exception that an important decision can not be backed up by consultation of a model-driven decision support system or based upon a systematic model-driven training.

MODEST has a mathematical core. It builds on a comprehensive, interdisciplinary work program, based on disciplinary expertise in mixed-integer optimal control and existing collaborations with medical and educational experts. It is both timely, given the increasing availability of data and the maturity of mathematical methods, models, and software; as well as high-impact, due to the large number of clinical areas that may benefit from optimization-based decision support and training tools.";1998500;1998500;ERC-2014-CoG;ERC-COG;OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG;DE;;; 194913;653961;IPAD-MD;SIGNED;H2020-EU.1.4.3.2.;INFRASUPP-6-2014;H2020;Research Infrastructures for Phenotyping, Archiving and Distribution of Mouse Disease Models - Promoting International Cooperation and User Engagement to Enhance Biomedical Innovation;1/06/2015;31/05/2019;;"The IPAD-MD project addresses cooperation and coordination between the pan-European INFRAFRONTIER Research Infrastructure and complementary research infrastructures in America, Asia and Australia, contributing to the global effort of the International Mouse Phenotyping Consortium (IMPC). In order to increase the reach of INFRAFRONTIER, IPAD-MD will also reach out to complementary infrastructures and user communities in Africa.
IPAD-MD will organise a series of workshops to achieve three major objectives:

1) Strengthen the coordination between the global research infrastructures. A particular focus of IPAD-MD will be to improve global access to the common resources created by INFRAFRONTIER and the IMPC and to align the scientific strategy with international research agendas.
2) Promote the involvement of the key international stakeholders to improve the resources and services offered by INFRAFRONTIER and established in the context of the IMPC. IPAD-MD will involve funders and program offices in the discussions about the future of the resources and services developed in INFRAFRONTIER and the IMPC.
3) Coordinate globally the development of innovative technology solutions for the improvement of the resources and services provided by INFRAFRONTIER and the IMPC. Importantly, the development of related quality control measures to sustain the high quality standards established in INFRAFRONTIER and in the IMPC, ensuring the reproducibility of results.

The outcomes of the IPAD-MD workshops will be made available in reports and in key publications in scientific journals and on the INFRAFRONTIER and IMPC websites. A dedicated Communications & Dissemination Group will ensure the outreach to the wider scientific community and to the general public. The IPAD-MD will improve the quality and global accessibility of high-quality resources and services enabling the biomedical research community to tackle the global health challenges.";1109863,75;1103613,75;H2020-INFRASUPP-2014-2;CSA;Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH);DE;"EUROPEAN MOLECULAR BIOLOGY LABORATORY;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;MEDICAL RESEARCH COUNCIL;INFRAFRONTIER GMBH;Centre Europen de Recherche en Biologie et Mdecine;CONSIGLIO NAZIONALE DELLE RICERCHE;Toronto Centre for Phenogenomics Inc.;UNIVERSITAT AUTONOMA DE BARCELONA;USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE;Genome Research Limited";"DE;ES;UK;FR;IT;CA;CZ"; 194609;649737;BUStoB;SIGNED;H2020-EU.3.3.7.;EE-04-2014;H2020;BUILD UP Skills to Business;1/03/2015;28/02/2018;;"This project is directed towards establishing and upgrading large-scale qualification and training schemes in the Netherlands for craftsmen and other on-site workers, in the continuation of the BUILD Up Skills Initiative. The proposed project uses the results of the IEE-projects and is a necessary step towards closing the gap between existing and needed skills for craftsmen and building workers in the Netherlands in the respect of meeting the 2020 energy objectives. The main objective of the project is to develop and pilot missing training materials on EQF-levels 2 - 4 based on the future-ready qualification schemes developed in BUILD UP Skills Pillar II. Secondary objective is to construct short skill measurement tests which enables the prevention of mistakes made by unconsciously incompetent workers, the detection of skills gaps and supply of industry relevant upskilling advice to craftsmen and building workers.Tertiary objective is to organise regional pilots in which we focus on implementation and evaluation of the developed materials and regional capacity building. We will support regional training partnerships with train-the-trainer sessions, regional labour market intelligence and implementing the developed trainings and assessments in practice in regional building and/or renovation projects. As results of the project the following will be achieved:
Increase the skills of 3000 craftsmen by the end of year 2018
Increase in RES-production of 11 GWh/year
Decrease of energy consumption of 69 GWh/year (EE)
Increase the employability of the building workforce with 3000 of which at least 5% women
Increase in investments in innovative sustainable energy technologies with 42.7 million
Acquired additional funding of 1.000.000,- to sustain the action";1392562,5;1392562,5;H2020-EE-2014-3-MarketUptake;CSA;STICHTING OPLEIDINGS- EN ONTWIKKELINGSFONDS VOOR HET TECHNISCH INSTALLATIEBEDRIJF*ST.POL.- EN ONTWIKK.FONDS TECH INSTALL.BEDR OTIB;NL;"MBO RAAD;STICHTING ROC NIJMEGEN EO;STICHTING KENTEQ, KENNISCENTRUM BEROEPSONDERWIJS BEDRIJFSLEVEN VOOR TECHNIEK;STICHTING ROC MIDDEN NEDERLAND;STICHTING INSTITUUT VOOR STUDIE ENSTIMULERING VAN ONDERZOEK OP HETGEBIED VAN GEBOUWINSTALLATIES;STICHTING REGIONAAL ONDERWIJS CENTRUM 'S HERTOGENBOSCH;STICHTING SBRCURnet;STICHTING REGIONAAL OPLEIDINGENCENTRUM VAN TWENTE;STICHTING KENTEQ";NL; 194596;649621;GreenPlay;SIGNED;H2020-EU.3.3.1.;EE-11-2014;H2020;Game to promote energy efficiency actions;1/03/2015;28/02/2018;;"The GreenPlay project consists in raising awareness among citizens through the implementation of a real time monitoring energy consumption platform and the development of a serious game.

This system will consist of four key elements:
A monitoring energy consumption in real time
A web-based platform to monitor its consumption
Advice and challenges available for users on the platform to reduce consumption
A serious game to raise awareness of users

The demonstration of this project will take place in three European cities and reach at least 200 homes. These targeted homes, located in public owned buildings, will have to fulfil two conditions:

i. Being heated with electricity
ii. Having an internet access

The expected impact of the solution is to decrease by 30% the energy consumption of the testing homes.";1705500;1705500;H2020-EE-2014-2-RIA;RIA;CHAMBRE DE COMMERCE ET D'INDUSTRIE DE BAYONNE PAYS BASQUE;FR;"BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM;EUROQUALITY SARL;FUNDACION AXENCIA INTERMUNICIPAL DA ENERXIA DE VIGO;EGREEN;IKASPLAY SL";"HU;FR;ES"; 194679;650702;SmartAct-2-3;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Scaling of a midsized patented low energy, light weight, highly efficient actuator to meet the demands of smaller and larger scale functions;1/10/2014;28/02/2015;;"The Smart Actuator Company Ltd develops smart, RIFT Driven actuators our first was delivered to market in Q3-2013. The system is proven to use 25% less copper, be 80% lighter and 75% more energy efficient than our competitors. Early success means that the first two years production scheduling is already sold to 90% capacity and The Smart Actuator Company now own global rights for the use of RIFT Technology in electrically powered actuators. Put simply, we believe our technology is a game changing product capable of delivering benefits worldwide by dramatically reducing;
energy required to automate everyday tasks in many applications
volume of raw materials, including copper and magnets, used to manufacture automated systems
inventory and therefore administration complexity
weight, thereby reducing fuel use in logistics and shipping
Carbon Footprint in manufacturing and distribution
need for sourcing manufacturing capability outside Europe";71429;50000;H2020-SMEINST-1-2014;SME-1;THE SMART ACTUATOR COMPANY LTD;UK;;; 194601;649673;EnerGAware;SIGNED;H2020-EU.3.3.1.;EE-11-2014;H2020;Energy Game for Awareness of energy efficiency in social housing communities;1/02/2015;31/01/2018;;"The main objective of the EnerGAware project is to achieve a 15-30% energy consumption and emissions reduction in a social housing pilot and increase the social tenants understanding and engagement in energy efficiency.

The EnerGAware project will develop and test, in publically owned social housing, a serious game that will be linked to the actual energy consumption (smart meter data) of the game users home and embedded in social media and networking tools. The solution fits within all three ICT areas suggested in the topic EE-11 scope: gaming, social networking and personalised data driven applications.

The EnerGAware solution will provide an innovative IT ecosystem in which users can design their own virtual home and Avatar and learn about the potential energy savings from installing energy-efficiency measures and changing user behaviour, whilst maintaining the comfort of their Avatar. The user will need to learn to balance the energy consumption, comfort and financial cost of their actions. Energy savings achieved both virtually in the game, calculated by building performance simulation, and in reality, in the users actual homes, measured through smart meter data, will enable progression in the serious game. The social media features will provide users a platform to share data of their achievements, compete with each other, give energy advice, as well as, join together to form virtual energy communities.

The EnerGAware solution will be developed and deployed with the cleanweb philosophy in mind: Capital light, Quick to market and Quick to scale, therefore the EnerGAware project will aim to go beyond just testing in a social housing pilot, but will seek commercial exploitation of the solution at the end of the project, through our industrial partners, in particular EDF Energy, a global energy provider, with 38 million European energy customers.";1963225;1963225;H2020-EE-2014-2-RIA;RIA;UNIVERSITAT POLITECNICA DE CATALUNYA;ES;"FREMEN CORP;ADVANTIC SISTEMAS Y SERVICIOS SL;UNIVERSITY OF PLYMOUTH;INSTITUTO SUPERIOR DE ENGENHARIA DO PORTO;DEVON AND CORNWALL HOUSING LTD;EDF ENERGY R&D UK CENTRE LIMITED";"FR;ES;UK;PT"; 194775;652291;usenns;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Neurotechnology to understand the emotions of customers in market research;1/09/2014;30/11/2014;;"Human-Centric Marketing is the current trend in marketing that looks at customers holistically, recognizing their emotions as one of the most important dimensions. All experts indicate that only the companies that adapt to this trend will successfully survive the current competitive and global environment. However, traditional market methodologies cannot objectively measure emotional insights as this information is unconscious and cannot be accessed under rational processes. BitBrain has already developed a neurotechnology solution able to measure emotions completely adapted to the market research sector, and the objective of the usenns project is to penetrate the market.
This solution has 3 main innovations: i) two new measurement devices (neuroheadset and a ring) adapted to the market research sector; ii) the encapsulation and integration within the technology of all the neuroscience knowledge on design-execution of experiments and on elaborated data analysis, in a completely transparent manner for the user; and iii) presentation of the results on emotions of consumers in a comprehensible and valuable language for the market researcher and its client. This results in a technology easy to implement in market research companies without incurring a risk due to high initial investments (clients pay an affordable price for the measurement devices), and a pay-per-use with a reasonable price only charged at the end of a study. This pay-per-use service with a visualization and interaction web-based application make this business model highly scalable.
The objectives of the feasibility project are to accelerate the process of corroborating the business plan, and to define an action plan to reach mainstream commercial use from the current prototype state. After the feasibility study, the action plan will bring to the market a solution that will revolutionize the global market research sector by helping companies to design better strategies adapted to their customers";71429;50000;H2020-SMEINST-1-2014;SME-1;BIT&BRAIN TECHNOLOGIES SL;ES;;; 194669;650549;ALGAEPRINT;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Algae Products' Internationalization;1/10/2014;28/02/2015;;"Microalgae are an inexhaustible source of proteins, lipids, pigments, vitamins or carbohydrates, among others. Therefore, they find potential commercial applications in several sectors of economic activity. Some of them are already commercially viable, such as aquaculture, agriculture, human nutrition or cosmetics, while some others still need R&D to be further developed, such as bioenergy or feed.

In addition, bearing in mind that microalgae are the most efficient natural CO2 capturing system, are very productive and do not compete with fertile lands, they have potential to simultaneously contribute to palliate the big crisis humankind is facing: environmental sustainability, energetic efficiency, and food security.

AlgaEnergy, a solid Spanish biotechnology based SME, did identify this potential. Since its establishment, it has served as a vehicle to consolidate the existing knowledge within the scientific field of microalgae in Spain -a recognized international hub in the matter-, which was dispersed across universities. Using it as a stepping stone, it has been investing in generating further R&D in order to scale-up the processes and develop ready to market products, so that the achievements in the laboratory phase reach also the society.

Within this task, AlgaEnergy has recently been able to reach a semi-industrial scale (TRL 7) with the start of the first phase operations of its semi-industrial plant in South of Spain, that captures real flue gas emissions directly from the second biggest combined cycle plant in Europe, being a worldwide premier. Therefore, AlgaEnergy is now ready to orientate its technology towards the commercialization of its already commercially viable products.

Algae Products' Internationalization (ALGAEPRINT) is based on the commercial orientation that is needed to make AlgaEnergy financially autonomous, after 7 years and millionaire resources invested in applied R&D.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALGAENERGY SA;ES;;; 194903;653861;Silver Stream;SIGNED;H2020-EU.3.4.;GV-5-2014;H2020;Social innovation and light electric vehicle revolution on streets and ambient;1/06/2015;31/05/2018;;"The SilverStream project addresses the challenges associated with sustainable and affordable personal mobility for the growing and ageing population in congested European cities. The project combines both ergonomic concepts conceived for elderly people and advanced automotive technologies that are quiet, clean, energy efficient and safe. The particular objectives of SilverStream are: i) specifications related to the needs of urban and ageing population; ii) enhanced vehicle manoeuvrability for urban context; iii) sustainable ergonomics, health monitoring and adaptive HMI for minimum-fatigue vehicle operation; iv) dual voltage 12/48 V power network for modular and scalable E/E architecture; v) hybrid energy storage system for extended operating life and increased efficiency; vi) compact in-wheel drive units for light urban mobility solutions; and vii) maximizing project impact for enhanced European competitiveness.
To achieve these objectives, the SilverStream project brings together 10 committed and complementary European partners that cover the whole value chain, including SMEs, large industry, academia and research institutes. The developed technologies will be driven by a team of expert in the field of medical and cognitive science domain through a top/down approach, and will be demonstrated with a vehicle prototype running in a realistic test environment.
In conclusion, SilverStream will develop and demonstrate a radically new light and affordable vehicle concept (L-category). In doing so, SilverStream provides one possible mobility solution to address the tough challenges faced by Europe in relation to the field of air quality, noise and environmental protection, traffic congestion, competiveness and jobs preservation, as outlined in the specific challenge of the work programme.";4573567,5;3990111,25;H2020-GV-2014;RIA;INFINEON TECHNOLOGIES AG;DE;"IDEAS & MOTION SRL;MAXWELL TECHNOLOGIES SA;ELAPHE POGONSKE TEHNOLOGIJE DOO;M.T.M. SRL;JAC ITALY DESIGN CENTER SRL;UNIVERSITY OF SURREY;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;INFINEON TECHNOLOGIES AUSTRIA AG;FONDAZIONE CENTRO SAN RAFFAELE";"IT;CH;SI;UK;DE;AT"; 194576;649396;ADEMU;SIGNED;H2020-EU.3.6.;EURO-1-2014;H2020;A Dynamic Economic and Monetary Union;1/06/2015;31/05/2018;;"In response to the European debt crisis and associated deep recession, a number of important steps have recently been taken towards redesigning the institutional architecture of EMU, based on the roadmap outlined in the Van Rompuy Report (2012). But these institutional innovations in particular the fiscal compact, the ESM, the SSM and the SRM retain relatively weak theoretical foundations. In particular, there is a noticeable gap between policy-oriented analyses of the precise EU challenges, and the major developments in dynamic macroeconomic theory of the past three decades.
ADEMU brings together eight research groups from leading European institutions with the aim of closing this gap. It studies the overall monetary and fiscal structure of the EU and the euro area, and the mechanisms of fiscal policy coordination among member states, with specific focus on: i) ensuring the long-term sustainability of EMU, addressing issues such as debt overhang, fiscal consolidation, public debt management, risk-sharing within the union, and crisis management mechanisms; ii) building resilience to economic shocks, with special emphasis on the coordination of fiscal policies, fiscal multipliers and labor market risks; and iii) managing interdependence in the euro area, analyzing both fiscal and financial spillovers and the effects of macroeconomic imbalances on financial and money markets, and, to confront these issues, new forms of banking regulation and monetary policy.
ADEMU is at the frontier of dynamic macroeconomic research, and the project will generate new knowledge that will be used to provide a rigorous assessment of the current institutional framework, and detailed proposals for improving it. It will also be a focal point in debates among academics, policymakers and other stakeholders regarding the implementation of new policies. The scope of the project will include a full consideration of political economy and legal dimensions to alternative institutional reforms";2499999;2499999;H2020-EURO-SOCIETY-2014;RIA;EUROPEAN UNIVERSITY INSTITUTE;IT;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UNIVERZITA KARLOVA;FUNDACIO PRIVADA BARCELONA GRADUATE SCHOOL OF ECONOMICS;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN;FONDATION JEAN-JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES;UNIVERSIDADE CATOLICA PORTUGUESA;UNIVERSITY COLLEGE LONDON";"UK;CZ;ES;DE;FR;PT"; 194539;648518;SUPERCELL;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Single-Use paPER-based fuel CELLs;1/07/2015;30/06/2020;;"The advances in paper microfluidics taking place in recent years show that the new generation of paper-based devices will be able to overcome the limitations of traditional lateral flow tests and offer more accurate and specific information. However, the quantification of paper devices signals by colorimetry, electrochemistry or fluorescence entails the use of sensors and electronic components that require energy to function. Up to now, this has been solved by the use of battery-powered bulky readers, but this is only cost-effective when the reader is meant to be used thousands of times (hospital, care rooms, etc). It is becoming clear that the proliferation of paper-based sensors and their enormous potential impact when applied to personalized healthcare ask for innovative solutions that provide affordable readout. Despite dedicated on-chip solutions that integrate all the required components within a disposable test seem to be the most promising approach, available examples of realization are still scarce.
The SUPERCELL project aims to develop a new generation of disposable and low environmental impact fuel cells. The approach presented in this proposal will be a major breakthrough in the fuel cell field, as these devices are conceived for the first time as single-use and disposable power sources. It will also have an enormous impact in the point-of-care diagnostics domain, as it will provide simple, reliable and clean power sources to an upcoming generation of smart paper-based sensors and allow them to be energetically autonomous. Fuel will be harvested from the biological sample to be analyzed in case of urine and blood or taken from hydrogen produced in situ upon the addition of any liquid in the paper platform. The proposal is very innovative in conception as well as in technology as these devices will be developed by means of a smart integration of paper microfluidics, printed electronics and electrocatalysis technologies.";1920738;1920738;ERC-2014-CoG;ERC-COG;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 194496;647328;RNArepair;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Site-directed RNA Editing to Manipulate RNA and Protein Function;1/08/2015;31/07/2020;;"Enzymatically active RNA-guided proteins, like the RNA-induced silencing complex (RISC), are particularly versatile tools for the rationally programmed manipulation of genetic information. After successful re-addressing of various natural RNA-guided machineries it is now time to tackle the engineering of novel, user-defined tools. With this respect we have recently achieved the engineering of an RNA-guided adenosine-to-inosine RNA editing machinery. Since inosine is biochemically read as guanosine, A-to-I editing alters genomic information on the RNA-level and may potentially allow for the manipulation of RNA processing or protein function. We have already achieved to apply our RNA editing approach for the repair of several missense and nonsense point mutations on reporter and disease-related genes in vitro and demonstrated its applicability in mammalian cell culture.

Now, we want to push the method further towards application. To enable editing in oocytes, primary cells and neurons, we will establish to deliver the editing tool by lentiviral vectors and stabilized mRNAs. We further aim to create cell lines expressing the artificial editing machinery under conditional control. We will repair reporter genes in developing worm oocytes, and we want to reconstitute mutations that cause neuro-diseases. We also wish to establish new features including photocontrol and the application of editing to steer protein localization.

If successful, site-directed RNA editing will enable us to manipulate RNA and protein function in a yet unprecedented way. The ready introduction of point mutations into mRNAs without the need for genomic engineering may dramatically facilitate the study of protein function, disease mechanism and may even allow for the treatment of diseases based on personalized genetic information.";1808200;1808200;ERC-2014-CoG;ERC-COG;EBERHARD KARLS UNIVERSITAET TUEBINGEN;DE;;; 194664;650485;MICROAB;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Micro machining with abrasive waterjets;1/10/2014;31/03/2015;;"Miniaturisation of products requires non-contact machining of micro components. Lasers, wire discharge machining (EDM) and abrasive waterjets are the three main non-contact machining methods but abrasive waterjets have yet to be commercialised for micro machining. This project will result in micro abrasive waterjets becoming an established method for micromachining components from ceramics, metals, glasses, composites and layered materials.

Finepart Sweden AB has been assigned patented and patent applied technologies by a UK based pioneer of micro abrasive waterjets in exchange for shares. A prototype micro abrasive waterjet system, with cutting jet diameters down to 80 m, has been used to cut a wide range of materials and material thicknesses. Technical developments will be scalable to smaller cutting jet diameters and for exploitation in fine and macro machining.

Finepart manufactures and sales a fine abrasive waterjet machining centre whose platform is constructed to advanced machine tool standards with accuracies needed for micromachining. The machining platform will be adapted for micromachining including 5 axis capabilities.

It is estimated that the development of micro cutting capabilities will increase the market for abrasive waterjet based machine tools by 20%. The market in 2014 is estimated at EUR 0.7 billion with predictions it will grow to over five times its current size.

Fineparts strategic objective is to develop an international business based on micro abrasive waterjet machining centers. Selling will be through a global network of machine tool distributors with an extensive European distributor network in place when sales of micro abrasive waterjet center commence. A business plan will set out the technical developments needed and costs to demonstrate the commercial viability of micro abrasive waterjets and the management and commercial actions to develop Finepart. The business plan will form part of a proposal for stage 2 funding.";71429;50000;H2020-SMEINST-1-2014;SME-1;FINEPART SWEDEN AB;SE;;; 194590;649496;EXCEPT;SIGNED;H2020-EU.3.6.;YOUNG-1-2014;H2020;Social Exclusion of Youth in Europe: Cumulative Disadvantage, Coping Strategies, Effective Policies and Transfer;1/05/2015;30/04/2018;;Against the background of increasing labour market insecurities among youth during the recent crisis, the aim of this interdisciplinary and internationally comparative project is to provide a comprehensive understanding of the consequences of youth labour market vulnerability for risks of social exclusion in Europe. A multidimensional dynamic perspective on both objective and subjective dimensions of the social exclusion of young people is adopted in order to identify the complex interrelationships and potential risks of cumulative disadvantages and possible compensatory mechanisms. Specifically, implications of labour market insecurities for youths risks of poverty and material deprivation, their subjective well-being and health status as well as their ability to reach independence from parental home are investigated in a mixed-method approach. First, qualitative interviews are conducted with youths from nine selected European countries including Ukraine in order to reach an in-depth understanding of how disadvantaged youths perceive their social situation and try to cope with it in different economic, institutional and cultural environments. Second, quantitative methods are applied using EU-28 and national micro-data in order to identify the causal interrelationships and dynamic processes of youths social exclusion in different national contexts. Third, the diffusion and effectiveness of EU and national policies that address various issues of youth social exclusion are assessed in EU-28 based on expert interviews and policy evaluation analyses. A central objective of this comparative project is to learn about examples of best practises and provide suggestions for reforms and policies that help improving the social situation of young people who face labour market insecurities and also involve youth own voice in this process. By involving and addressing different stakeholder groups at all stages of the project the dissemination of results will be ensured.;2497416,25;2497414,75;H2020-YOUNG-SOCIETY-2014;RIA;TALLINN UNIVERSITY;EE;"INTERNATIONAL CIVIC ORGANISATION KYIV ECONOMICS INSTITUTE;INSTYTUT BADAN EDUKACYJNYCH;ARISTOTELIO PANEPISTIMIO THESSALONIKIS;UNIVERSITAET DUISBURG-ESSEN;UNIVERSITY OF KENT;UNIVERSITA DEGLI STUDI DI TORINO;UMEA UNIVERSITET;OTTO-FRIEDRICH-UNIVERSITAET BAMBERG;Institute for the Study of Societies and Knowledge";"UA;PL;EL;DE;UK;IT;SE;BG"; 194481;647000;MobiliSense;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Air pollution and noise exposure related to personal transport behaviour: short-term and longer-term effects on health;1/07/2015;30/06/2020;;"To support policies at the European and national levels, MobiliSense aims to explore the effects of air pollution and noise exposure related to personal transport habits on respiratory and cardiovascular health. Building on methods from Epidemiology, Geography, and Transport sciences, the objectives of MobiliSense are to quantify the contribution of personal transport to the air pollution and noise exposure of individuals; to compare the air pollution and noise exposure in the different transport modes; to investigate whether total and transport-related personal exposure to air pollutants and noise are associated with short-term and two-year changes in respiratory and cardiovascular health; and to examine whether transport-related exposures mediate socioeconomic disparities in health. The MobiliSense project will use passive and active sensors of location, behaviour, environmental nuisances, and health in a representative sample of 1000 participants followed-up over two years. It addresses a gap in knowledge: (i) by assessing transport behaviour over 8 days with GPS receivers and an electronic mobility survey; (ii) by considering the personal exposure to both air pollution and noise and improving its characterisation (inhaled doses, noise frequency components, impulsive noise, and interactions with subjective annoyance); (iii) by measuring a wide range of respiratory and cardiovascular outcomes (smartphone-assessed respiratory symptoms, lung function assessed by spirometry and impedance pneumography, resting blood pressure, ambulatory brachial / central blood pressure, and heart rate variability); and (iv) by investigating short-term and longer-term effects of transport. To assist policy-makers, the final aim is to deliver a simulation tool permitting to determine the extent to which scenarios (i) of changes in personal transport behaviour and (ii) of changes in exposure levels during transport affect individual exposure and respiratory / cardiovascular health.";2000000;2000000;ERC-2014-CoG;ERC-COG;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;FR;;; 194777;652350;AERFOR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Proactive Passenger Flow Management for Airports with an Advanced Forecasting System;1/10/2014;28/02/2015;;"The worldwide airport passenger volume increased from 2000 to 2014 from 1,6 Billion to over 3,3 Billion passengers and further growth is already predicted. The steady increase of available passenger capacities therefore is one of the most important targets for airports in Europe and worldwide. Ideally this passenger increase can be reached with existing airport infrastructure and without the necessity to invest in new buildings and facitlities.

AMORPH.aero is an innovative airport software solution for proactive passenger flow and resource allocation analysis and management by means of advanced forecasting methods. It is build upon Amorph Systems unique OFC-Technology (OFC = Online Forecast) for accurate and fast forecasting of logistic systems.

AMORPH.aeros innovative concept supports in a proactive instead of reactive management of problems in passenger flow. The decision makers can perform what-if scenarios, executing validation forecasts before deciding to take a specific measure.

AMORPH.aero is operated very successfully at the International Airport in Frankfurt and improved Frankfurt's competitiveness to other airports worldwide significantly. At the beginning of the project the maximum number of passengers was between 54-56 Million per year. Now the maximum capacity is positioned between 62-64 Million per year without investing in new infrastructure.

As a next step Amorph Systems plans to market AMORPH.aero to other airports in Europe and worldwide. Airports will gain high advantages by being able to
- increase airport capacity with existing infrastructure
- reduce required investments in new airport buildings
- contribute to environmental targets by optimally using existing airport facilities
- enable more efficient resource planning
- realize significant cost savings
- gaining more satisfied customers.";71429;50000;H2020-SMEINST-1-2014;SME-1;AMORPH SYSTEMS GMBH;DE;;; 194649;650195;SeagateSail;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;20% fuel saving for commercial vessels through a hybrid wind plus motor cruise mode.;1/10/2014;31/03/2015;;"Seagate is developing an innovative collapsible-automatic-retrofittable delta wing sail that can be applied to commercial vessels. Seagate Sail and cruise control aims to provide an adoptable and beneficial solution for commercial ship owners to reduce their fuel bills and cut emissions by 20%. The system is able to offer a solution to both problems whilst at the same time being suited to the needs of commercial ships, which makes the solution unique and highly desirable. The Seagate Sail, installed on the vessels deck, will convert wind into driving force. The Seagate Cruise Control will convert the driving force into fuel saving, by proportionally reducing the engine power. With the Seagate solution, the vessel will cruise at the original speed (and therefore keep to the Estimated Time of Arrival) using 20% less fuel.
The solution is at a mature stage of development and therefore the feasibility assessment will focus on the development of the industrial chain to set-up and validate the scale-up production of Seagate Sail, a sound IP management strategy, solid financial projections and the sale agreements for the commercialisation. The sails will be developed in Europe involving different industrial partners, managed by a British and Italian team. Once commercialised, Seagate will maintain its headquarters and manufacturing activities in Europe offering new job opportunities across the continent. Seagate aims to set a commercial partnership with a top European engine supplier to speed up the commercial growth of its products in Europe and Worldwide.";71429;50000;H2020-SMEINST-1-2014;SME-1;SEAGATE SRL;IT;SMAR Azure Ltd;UK; 194581;649439;FairTax;SIGNED;H2020-EU.3.6.;EURO-1-2014;H2020;Revisioning the Fiscal EU: Fair, Sustainable, and Coordinated Tax and Social Policies;1/03/2015;28/02/2019;;"Plans for economic and monetary integration in the European Union call for fundamental changes in fiscal relations among EU member states and other countries. The 2012 Blueprint for the European Monetary Union (EMU) calls for deeper integration of fiscal policies at the level of domestic EU members, including establishing EU own-source revenues. The 2013 Social Dimension of the EMU emphasizes that this fiscal revisioning must also improve coordination of employment and social policies post-crisis to counteract declines in state revenues, evaluate fragmented policy initiatives during the crisis, and improve human well-being and capabilities ends in themselves and as preconditions to stable integration and sustainable growth.

This project will carry out in-depth comparative, interdisciplinary research using constitutional, legal, technical, institutional, qualitative, and quantitative methods to address four core issues:

* Options for expanding EU legislative competences or governance mechanisms for
effective harmonization of member tax and social policies;
* Reform options for state-level coordination of fairer, more stable, and more sustainable tax and social policy regimes;
* Strategies for the increased effectiveness and harmonization of tax administration and
compliance structures within the EU and non-EU areas; and
* Recommendations for true own-source EU revenues.

This project is relevant to fundamental political and structural challenges that face the EU as it pursues deep fiscal integration. Fiscal policies encompass both revenue production and state spending priorities, and have tremendous impact on life choices, business planning, and economic development. Whether under conditions of stable growth or disruption, state revenues remain at the heart of state governance capacities; throughout, the well-being of the population as a whole remains at the heart of social and political stability and productivity.";2889000;2472750;H2020-EURO-SOCIETY-2014;RIA;UMEA UNIVERSITET;SE;"Queen's University at Kingston;THE UNIVERSITY OF EXETER;LINKOPINGS UNIVERSITET;MENDELOVA UNIVERZITA V BRNE;STIFTELSEN HANDELSHOYSKOLEN BI;COPENHAGEN BUSINESS SCHOOL;NATIONAL UNIVERSITY OF IRELAND, GALWAY;FUNDACAO GETULIO VARGAS;OSTERREICHISCHES INSTITUT FUR WIRTSCHAFTSFORSCHUNG VEREIN;KING'S COLLEGE LONDON";"CA;UK;SE;CZ;NO;DK;IE;BR;AT"; 194760;651964;SliceWatch;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;Monitoring Meat Texture To Optimize Slicing Yield And Reduce Wasted Meat In High-Speed Slicing Lines;1/09/2014;31/01/2015;;"Meat processing industry generates an annual turnover of 160.6b in the EU-25, from which 50% corresponds to meat processing SMEs. Over the past years, the demand for sliced cured meat products has steadily grown driven by the higher acceptance of consumers for ready-to-eat products. Despite the growing market demand, operational costs of automated slicing lines are significant. Meat losses represent over 5% of the total costs, and are responsible for wasting tons of meat yearly in Europe. About t10,000 and t3,0000 of meat are annually lost during bacon and ham slicing operations, respectively, with an impact of over 110M.
To a great extent, the variability in meat texture is responsible for these losses. Besides the associated economic and environmental implications, variations in product texture are responsible for frequent line stoppages, and reduced processing throughput.
Based on our patent-pending electromagnetic scanning technology, we aim at developing a non-destructive inspection system to evaluate in-line meat texture before slicing. SliceWatch would allow diverting soft or hard pieces from the slicing line, thus preventing line stoppages and minimizing meat losses. This technology shall constitute a breakthrough innovation in the meat processing sector, and shall allow meat producers to reduce manufacturing costs and waste generation. Being a niche market, we estimate the total market value for SliceWatch in Europe in 150M. We expect to generate a NPV of 6M over a 5 years period after starting commercialization (ROI=3.9).
In collaboration with a potential client, we have already assessed the economic and technical feasibility of the project in a production line of sliced cured ham. Through this innovation project we aim at: (1) completing the technical feasibility study, and elaborating a detailed business plan Phase I; and (2) developing and demonstrating a complete qualified system (TRL8) Phase II.";71429;50000;H2020-SMEINST-1-2014;SME-1;LENZ INSTRUMENTS SL;ES;;; 194622;649820;FLEXYNETS;SIGNED;H2020-EU.3.3.1.;EE-13-2014;H2020;Fifth generation, Low temperature, high EXergY district heating and cooling NETworkS;1/07/2015;30/06/2018;;"District Heating and Cooling networks distribute energy from a centralized generation plant to a number of remote customers. As such, actual DHC systems suffer from
significant heat losses
highly unexplored integration potential of different available energy sources (e.g. renewables and waste heat) into the network
high installation costs.
FLEXYNETS will develop, demonstrate and deploy a new generation of intelligent district heating and cooling networks that reduce energy transportation losses by working at neutral temperature levels. Reversible heat pumps and chillers will be used to exchange heat with the DHC network on the demand side. In this way, the same network can provide contemporary heating and cooling.
FLEXYNETS solutions will integrate effectively multiple generation sources (including high- and low-temperature solar thermal, biomass, PV, cogeneration and waste heat) where they are available along the DHC network, by managing energy at different temperature levels and assuring optimized exergy exploitation.
Together with storages, control strategies that optimize the harvest of renewable energy sources are key from the technical and economic points of view. On the one hand, strategies will be assessed that assure a thermal balance among diffused heat generation, storage and utilization. On the other, policies will be elaborated to decide when energy is to be gathered locally or exchanged (both purchased and sold) with the electricity and gas networks.
The optimal management of such new generation networks will lead to a synergic effect on primary energy savings (hence on the reduction of the CO2 emissions), assuring at the same time investment and operation profitability. As such, FLEXYNETS will contribute to a higher penetration of smart DHC networks on the heating and cooling market, and will contribute to the European recovery plan.";1999363,75;1999363,75;H2020-EE-2014-2-RIA;RIA;ACCADEMIA EUROPEA DI BOLZANO;IT;"SOLID AUTOMATION GMBH;PLANENERGI FOND;ENISYST GMBH;HOCHSCHULE FUR TECHNIK STUTTGART;ACCIONA CONSTRUCCION SA;LATERIZI GAMBETTOLA SRL";"DE;DK;ES;IT"; 194888;653642;VisiOn;SIGNED;H2020-EU.3.7.;DS-01-2014;H2020;Visual Privacy Management in User Centric Open Environments;1/07/2015;30/06/2017;;"Public Administration (PA) authorities are working towards upgrading the level of their online services through new governance models such as the Open Government. This pushes for greater transparency, accountability and innovation aiming at increasing citizen levels of confidence and trust in PA online services. In this context, user data privacy is an important issue. VisiOn will deliver a high Technology Readiness Level (TRL) Visual Privacy Management Platform, which empowers any citizen to achieve desired levels of privacy by creating and monitoring a personal Privacy Level Agreement. The platform will provide clear visualisation of privacy preferences, relevant threats and trust issues along with an insight into the economic value of user data. The platform will equip PAs with the right tools to improve the transparency and accountability of their operations, by supporting visual analysis of (i) privacy issues at different levels (e.g. design, run-time) and perspectives (i.e. citizen, PA); (ii) regulation compliance; and (iii) business/operational processes. The VisiOn consortium will leverage existing software, tools and methodologies, which partners have developed in previous projects, towards the implementation of the privacy platform software components. The latter will be tested in an operational environment (i.e. TRL 7), in three different pilot scenarios across two different scenario types (i.e. citizen/PA & PA/cross-border PA). Pilots will involve users from three European countries. Driven by the lack of appropriate products in the market, as identified by the relevant market analysis, the VisiOn exploitation strategy is based on commercialisation of the project results at three levels: platform-as-a-whole, fragments of the platform, and partner individual exploitation. This strategy will enable partners to integrate the project results into their existing commercial offerings, thus exploring and establishing new business opportunities and ventures.";3161000;2748912,5;H2020-DS-2014-1;IA;BUSINESS-E SPA;IT;"VELTI ANONYMI ETAIREIA PROIONTON LOGISMIKOU & SYNAFON PRIONTON & PIRESION;MINISTERO DELLO SVILUPPO ECONOMICO;UNIVERSITY OF BRIGHTON;SERVICIO MADRILENO DE SALUD;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;MILITARY MEDICAL ACADEMY;""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS"""""";UNIVERSITAET KOBLENZ-LANDAU;UNIVERSITA DEGLI STUDI DI TRENTO;ATOS SPAIN SA;DIMOS ATHINAION EPICHEIRISI MICHANOGRAFISIS;OSPEDALE PEDIATRICO BAMBINO GESU";"EL;IT;UK;ES;DE;BG"; 194654;650256;MPSAT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.6.";Space-SME-2014-1;H2020;Multi-Payload satellite as an innovative service for technology experimentation in space;1/10/2014;31/03/2015;;"The project objective is to provide a low-cost and fast service for test and evaluation of technology devices in outer space. The most outstanding added value of this proposal is to bring the space sector closer to technology developers through the standardization of the payload integration.

The rate of production of new components and technologies in the European space industry is currently not accomplished to the availability of opportunities for in-orbit testing. European space industry needs to increase rapidly the maturity level of these components, in order not to lose the leading position in terms of technological competitiveness and innovation. This situation brings the commercial opportunity for a low cost and time effective service to evaluate new technologies in space environment, providing a multiple payload integration service to gain heritage as fast as the industry is demanding at present.

This innovative business opportunity, called Multi-Payload Satellite (MPSAT), is focused on achieving a new concept of space mission based on small satellites for in-orbit demonstration. The proposed project will develop a feasible and flexible service, drastically increasing the availability of opportunities for in-orbit testing for the whole technology developers community.

The proposal concept mimics a previous successful initiative known as Multi-project Chip Wafer (MPW). MPW is a foundry service in microelectronics, where the share of the non-recurrent costs involved in the manufacturing of several integrated circuits on a single run drastically reduces its price. In this way, MPSAT service offers flight opportunities to the technology developers without resources for managing their own mission, offering dedicated payload slots and including all the mission steps as a unique kit: Mission management, platform assembly, payloads integration, operational and environmental tests, launch, and in-orbit experiment evaluation services.";71429;50000;H2020-SMEINST-1-2014;SME-1;SOLAR MEMS TECHNOLOGIES SL;ES;;; 194466;646659;NANOREACTOR;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Multiscale modelling of stimuli-responsive nanoreactors;1/08/2015;31/07/2020;;"The catalysis by metal nanoparticles is one of the fastest growing areas in nanoscience due to our society's exploding need for fuels, drugs, and environmental remediation. However, the optimal control of catalytic activity and selectivity remains one of the grand challenges in the 21st century.

Here, I propose to theoretically derive design rules for the optimization of nanoparticle catalysis by means of thermosensitive yolk-shell carrier systems. In the latter, the nanoparticle is stabilized in solution by an encapsulating, thermosensitive hydrogel shell. The physicochemical properties of this polymeric 'nanogate' react to stimuli in the environment and thus permit the reactant transport and the diffusion-controlled part of the catalytic reaction to be switched and tuned, e.g., by the temperature or the pH. The novel hybrid character of these emerging 'nanoreactors' opens up unprecedented ways for the control of nanocatalysis due to new designable degrees of freedom.

The complex mechanisms behind stimuli-responsive nanocatalysis call for a concerted, interdisciplinary modelling approach that has converged in my group in the recent years. In particular, it can only be achieved by combining my expertise in multiscale computer simulations of solvated polymers with the statistical and continuum mechanics of soft matter structures and dynamics. The key challenge is to integrate the molecular solvation effects and our growing knowledge of hydrogel mechanics and thermodynamics into advanced reaction-diffusion equations for a quantitative rate prediction. In addition, I envision exciting novel phenomena such as a chemo-mechanical 'self-regulated catalysis' or an amplifying 'resonant catalysis', if hydrogel response and fluctuations couple to the chemical output signal.

The expected results and design principles will help our collaborators to synthesize tailor-made, superior nanocatalysts and will advance our understanding of their structure-reactivity relationship.";1987500;1987500;ERC-2014-CoG;ERC-COG;HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH;DE;;; 194575;649395;NEGOTIATE;SIGNED;H2020-EU.3.6.;YOUNG-1-2014;H2020;Negotiating early job-insecurity and labour market exclusion in Europe;1/03/2015;28/02/2018;;"Through an innovative use of four key concepts (resilience, capability, active agency and negotiation) and primary data (life course interviews, vignette experiments), NEGOTIATE will deliver gender-sensitive comparative knowledge about consequences of early job insecurity. We move beyond the state-of-the-art by investigating the linkages across macro, meso and micro levels as mechanisms of early job insecurity. General labour market processes and a severe employment crisis currently define the macro level. The micro level is characterised by young people with unequal opportunities to influence individual job prospects. The organisation of meso level structures creates differential access to public and private support within and across countries. NEGOTIATEs core question is how young peoples scope for agency interacts with different layers of structural conditions in a multi-level governance system. By actively involving national and European stakeholders including young people NEGOTIATE will contribute to policies that promote the employability of young Europeans, thus maximising societal and scientific impact. We will observe the present, learn from the past and project the future to inform policies that help prevent early labour market exclusion and adverse effects of job insecurity in the short and long term, thereby leading Europe closer to the Europe 2020 goals.
A trans-disciplinary Consortium of nine research institutions from BG, CZ, DE, EL, NO, PL, ES, CH, UK and one international CSO will implement NEGOTIATE. The participating countries are differently affected by the economic crisis and display historical variations across key institutional factors, such as welfare state arrangements, employment relations and youth transition regimes. The participation of SOLIDAR will strengthen NEGOTIATEs policy impact. Overall, the participants wide set of research skills enable a rich combination of advanced quantitative and qualitative comparative analyses.";2919232,75;2476609;H2020-YOUNG-SOCIETY-2014;RIA;HOGSKOLEN I OSLO OG AKERSHUS;NO;"PANTEIO PANEPISTIMIO KOINONIKON KAIPOLITIKON EPISTIMON;Masarykova univerzita;UNIVERSITY OF BRIGHTON;SOLIDAR FOUNDATION FOR HUMANITARIAN DEVELOPMENT AND EUROPEAN COOPERATION;UNIVERSITAET BASEL;UNIVERSITAET BREMEN;UNIWERSYTET EKONOMICZNY W POZNANIU;Institute for the Study of Societies and Knowledge;UNIVERSITAT DE GIRONA";"EL;CZ;UK;BE;CH;DE;PL;BG;ES"; 194593;649538;CATCH-EyoU;SIGNED;H2020-EU.3.6.;YOUNG-5a-2014;H2020;Constructing AcTive CitizensHip with European Youth: Policies, Practices, Challenges and Solutions;1/09/2015;31/08/2018;;"The proposal will investigate young peoples views of the EU and of their role in building the EU through their participatory practices at EU, national, regional and local levels. These issues will be examined from an interdisciplinary perspective (Political Sciences, Sociology, History, Media and Communications, Education, Psychology) as building blocks for a new and groundbreaking conceptualization and theoretical model of youth active citizenship in the EU, including psychological citizenship and practices of social and political engagement.
To achieve this aim, the proposal will adopt an innovative approach combining traditional theoretical hypothesis testing with empirical-phenomenological analysis and allowing to integrate the perspectives of young people, as co-producers of knowledge, with those of researchers and other stakeholders. A wide range of research methods will be used including documentary and media analysis, interviews and focus groups, a cross-national longitudinal study, ethnographic case studies of participatory practices and a socially innovative intervention. These quantitative and qualitative methods will allow to develop a new, robust and cutting-edge conceptualization of youth active citizenship in the EU and new evidence-based multilevel integrated theoretical model.
This approach will offer a multifaceted understanding of the different factors influencing the perspectives of native EU citizens and the ways in which they engage in society, leading to groundbreaking changes in the ways in which youth engagement, participation and active citizenship are understood. Moreover, the project will provide policy makers with a set of evidence-based ideas, recommendations and instruments to integrate young peoples perspectives into various areas of policy-making. The findings of the project will thus fully cover the challenges, scope and impact of bringing the EU closer to its young citizens and boosting their participation.";2498786;2498786;H2020-YOUNG-SOCIETY-2014;RIA;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;IT;"TARTU ULIKOOL;Masarykova univerzita;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;FORUM NAZIONALE DEI GIOVANI ASSOCIAZIONE;FRIEDRICH-SCHILLER-UNIVERSITAT JENA;OREBRO UNIVERSITY;UNIVERSIDADE DO PORTO";"EE;CZ;EL;UK;IT;DE;SE;PT"; 194585;649473;PROF-TRAC;SIGNED;H2020-EU.3.3.7.;EE-04-2014;H2020;PROFessional multi-disciplinary TRAining and Continuing development in skills for NZEB principles;1/03/2015;28/02/2018;;"A successful design and construction process for NZE buildings and renovation requires to follow an integrated design approach and to work in multi-disciplinary teams. However, this approach is still not common PROF-TRAC offers a solution for this barrier by developing and maintaining an education platform for dedicated trainings and continuous development for professionals, i.e., both technical experts as architects, in integrated multi-disciplinary approach for nZEB principles, in a Post Graduate qualification/curriculum. PROF-TRAC has the following objectives:
1. Mapping of the required skills and current skills gap of professionals in NZEB.
2. Development of an open training platform including methods for a systematic and sustainable access to knowledge.
3. Development of a Train the Trainers programme for the developed curriculum and/or qualification scheme This training programme will be tested on a national scale in six national pilots and on an international scale by a train-the-trainer program provided by two EU umbrella organisations representing engineers (REHVA) and architects (ACE).
4. Development of a repository of the training material for use in education and post-initial education
PROF-TRAC is specifically targeting the need to train architects, engineers, building managers and other building professionals in the necessary skills for designing, constructing, managing and operating NZE construction and retrofitting. The proposed approach will lead to a substantial reduction of skills mismatch for professionals, Increased managerial capacity to support innovation and sustainable energy use in buildings through new leadership, design, construction and management skills for professionals at middle and senior level and fostering of a better cooperation between disciplines. PROF-TRAC is building upon previous IEE projects (BuildUpSkills, IDES-EDU etc.) and is initiated by the largest European associations for the sector (REHVA, ACE, CECODHAS).";1499871,25;1499871,25;H2020-EE-2014-3-MarketUptake;CSA;Huygen Installatie Adviseurs;NL;"COMITE EUROPEEN DE COORDINATION DE L'HABITAT SOCIAL AISBL;INSTITUTO VALENCIANO DE LA EDIFICACION;AALBORG UNIVERSITET;FUNDATECYR;CAE Services GEIE;STICHTING INSTITUUT VOOR STUDIE ENSTIMULERING VAN ONDERZOEK OP HETGEBIED VAN GEBOUWINSTALLATIES;CESKE VYSOKE UCENI TECHNICKE V PRAZE;HRVATSKA KOMORA INZENJERA STROJARSTVA;CESKA KOMORA AUTORIZOVANYCH INZEYRU A TECHNIKU;DANVAK APS;CONSIGLIO NAZIONALE DEGLI ARCHITETTI PIANIFICATORI PAESAGGISTI E CONSERVATORI;NEDERLANDSE TECHNISCHE VERENIGING VOOR INSTALLATIES IN GEBOUWEN TVVL;CONSEIL DES ARCHITECTES D'EUROPE;ZBORNICA ZA ARHITEKTURO IN PROSTORSLOVENIJE;FEDERATIE VAN VERENIGINGEN VOOR VERWARMING EN LUCHTBEHANDELING IN EUROPA VERENIGING";"BE;ES;DK;NL;CZ;HR;IT;SI"; 194762;651993;EB2BSN;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Let us build the first European Business-to-Business Social Network;1/10/2014;31/03/2015;;"ALG is an innovative SME founded in 2010, builder of the Attestation Lgale platform (http://www.attestationlegale.fr), currently in use by thousands of French businesses. The Attestation Lgale platform is a Software as a Service (SaaS) Web application through which businesses can share their administrative documents and can benefit from alerts and always up-to-date documents.

Because of the future implementation of a European directive that reinforces the obligation of diligence in Europe (http://www.lemoniteur.fr/165-commande-publique/article/actualite/23657764-bruxelles-adoption-definitive-des-directives-marches-publics-et-concessions), our objective and our main motivation for this project proposal are to investigate the possibility of deploying our solution on a European scale.

The deployment of such a solution will lead to the following outcomes:
- Improvement of the competitiveness of European businesses by the administrative simplification accelerated by the European directive;
- Better regulation in the context of worker secondment and contribute to the effort on countering unfair competition between multiple European Union businesses.

These outcomes will also lead to the following impacts:
- Usage disruption by eliminating the redundant processes and costs related to the diffusion and the collect of administrative documents;
- Technological disruption by modeling and exploiting these Business-to-Business social networks while respecting the requirement of privacy and data property specific to businesses actors;
- Data governance disruption by letting the members of our platform to remain the owner of the produced data.

The objectives of this phase 1 are to identify the European countries in which our solution can be deployed. If such countries are found in phase 1, the phase 2 would enable us to either prototype or modify our current solution to support these countries and to let their businesses benefit from our solution.";71429;50000;H2020-SMEINST-1-2014;SME-1;ALG;FR;;; 194873;653508;Phil-Threats;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;The Representation of External Threats in the Configuration of Spanish Power in the Philippines (1600-1800);1/02/2016;31/01/2018;;"Challenging the traditional understanding of colonial rule in the early modern period, this project proposes a new perspective on how colonial systems of dominance operated, offering an innovative view on mechanisms of governance. Applying interdisciplinary methods, it emphasizes political communication as key element in the creation and consolidation of a system of power. Focussing on the colonial Philippines as a transcontinental cultural contact zone, this project investigates the concept of external threats as a fundamental element of political communication. Thereby, it advances simultaneously along two analytic lines, investigating (1) forms of threat representation, and (2) their effects.

Based on the sociological theory that external threats can foster the cohesion of a group, the hypothesis of this project is that specific representations of enemies contributed to the success of the Spanish colonial system for a long period (1565-1898), by strengthening the unity within the Spanish system and helping to overcome internal problems. To prove this effect, the project combines aspects of (1) system theory (N. Luhmann) and (2) the method of dispositif analysis (M. Foucault), which until now have only been applied separately. Based on system theory models, a concept of threat-communication is defined as a first analytic step for the investigation. It is completed with the concept of a dispositif of threat, which includes not only discourses in texts, but also visual forms of representation, objects, and performative acts giving the project a pronounced interdisciplinary feature.

Overall, the project will contribute to a better understanding of the power structures of the Spanish colonial systems in particular and mechanisms of political communication in general. In addition, it will enhance the skills of the Experienced Researcher (ER), enabling him to become a leading expert in his field and to find an independent position in research.";170121,6;170121,6;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;;; 194898;653784;OrganoMag;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Organometallic Single-Molecule Magnets;1/10/2015;30/09/2017;;In this project, we will develop new single-molecule magnets (SMMs) that combine the strong magnetic anisotropy of lanthanide ions with a series of novel radical ligands. Highly unusual di- and tri-metallic Ln-SMMs are proposed in which the metals are bridged by radicals with heavy Group 15 donor atoms (i.e. the pnictogens, phosphorus-bismuth). The SMM field is dominated by systems with diamagnetic ligands: our radical ligands are novel, hence their applications in single-molecule magnetism will be unprecedented. We will exploit the rich electrochemistry of the proposed ligands: our DFT calculations show that the target heavy pnictogen radical anions have huge spin densities on the donor atoms, hence the diffuse unpaired spin of the radicals will provide a way of switching off the quantum tunnelling mechanisms that otherwise prevent hysteresis. Ultimately, this project introduces the potential for creating SMMs that show hysteresis at unprecedentedly high temperatures.;183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE UNIVERSITY OF MANCHESTER;UK;;; 194560;649160;Pro-Staph-ID;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical biomarker and rapid diagnostic test for Staphylococcus aureus induced ventilator-associated pneumonia;1/10/2014;31/12/2014;;"Hospital acquired infections such as ventilator associated pneumonia (VAP) are associated with unacceptably high mortality rates and spiraling healthcare costs. Staphylococcus aureus (S. aureus) is a major human pathogen, and one of the leading causes of VAP and other nosocomial infections. Vital to the effective management and treatment of S. aureus VAP is the use of appropriate antimicrobial therapies, and ideally prophylactic measures. Antibiotic stewardship efforts, aimed to reduce the spread of antibiotic resistance, are resulting in changing clinical guidelines so the causative pathogen is identified before antibiotic treatment is initiated. Such approaches rely on diagnostic measures to identify the infecting bacteria and resistance pattern, and usually take over 24 hours to complete. Therefore, early identification of patients at risk of developing VAP coupled with characterization of the causative pathogen would allow early treatment and potential prevention, ultimately translating to reduced mortality and healthcare cost.

The overall aim of this project is the clinical validation of a novel biomarker identified by Arsanis Biosciences to identify patients likely to develop S. aureus induced VAP. In parallel, we aim to develop a unique rapid diagnostic test incorporating this biomarker and detecting other markers to characterize the bacteria, for use to at the bedside to identify these at risk patients in the intensive care unit (ICU). The test is aimed to give the ICU clinician rapid information to inform early clinical intervention.

During the feasibility study we will assess the market and clinical utility of the diagnostic test through dialogue with KOLs, healthcare professionals and end users from a range of EU hospitals. We will also validate the format and design of the diagnostic kit, and design a road-map for clinical study and approval. We will also assess pricing and reimbursement issues and complete FTO analysis for the concept.";71429;50000;H2020-SMEINST-1-2014;SME-1;Arsanis Biosciences, GmbH;AT;;; 194745;651669;CAPTOR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.7.";DRS-17-2014-1;H2020;cAPTor captures Advanced System Threats;1/10/2014;28/02/2015;;"CAPTOR is a set of tools whose main objective is to characterize, identify and detect APTs as well as minimize their impact in the target organization. CAPTOR should be able to operate in complex environments, like Urban Critical Infrastructures, where IT, industrial, energy and network infrastructures must be protected from security threats.

The most important innovation of CAPTOR is the application of a set of techniques and methodologies known as anomaly detection, which will be later explained and an approach more akin to classic intelligence as opposed to the malware-detection-centered approach used by the vast majority of proposed commercial solutions.

S2 s objective is to position CAPTOR as a leading European toolset to protect Critical Infrastructures in general and Urban Soft Targets and Critical Infrastructures in particular.
Advances in the integration of ICT technologies in urban areas and their infrastructures have brought undeniable advantages to the cities economic management, inhabitability and have helped to reduce their environmental impact.

Unfortunately, together with these advantages, many cyber security vulnerabilities have been introduced in infrastructures where these threats have never before been taken into account. The threat posed by cyber terrorists and cyber criminals continually grows and organizations are increasing their awareness of the possibility of an incident.

An APT (Advanced Persistent Threat) is a planned multimodal attack targeted at a specific organization or infrastructure, where several types of malware, under control of a command center is combined with techniques like social engineering, use of insiders or access through third parties, with the objective of gaining access to critical physical or virtual assets and, exfiltrate information, obtain economic advantage or sabotage infrastructures. APTs are the most important kind of cyber attacks a critical infrastructure can suffer today.";71429;50000;H2020-SMEINST-1-2014;SME-1;S2 GRUPO DE INNOVACION EN PROCESOS ORGANIZATIVOS SL;ES;;; 194524;647989;Brain circRNAs;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Rounding the circle: Unravelling the biogenesis, function and mechanism of action of circRNAs in the Drosophila brain.;1/02/2016;31/01/2021;;"Tight regulation of RNA metabolism is essential for normal brain function. This includes co and post-transcriptional regulation, which are extremely prevalent in neurons. Recently, circular RNAs (circRNAs), a highly abundant new type of regulatory non-coding RNA have been found across the animal kingdom. Two of these RNAs have been shown to act as miRNA sponges but no function is known for the thousands of other circRNAs, indicating the existence of a widespread layer of previously unknown gene regulation.
The present proposal aims to comprehensively determine the role and mode of actions of circRNAs in gene expression and RNA metabolism in the fly brain. We will do so by studying their biogenesis, transport, and mechanism of action, as well as by determining the roles of circRNAs in neuronal function and behaviour. Briefly, we will: 1) identify factors involved in the biogenesis, localization, and stabilization of circRNAs; 2) determine neuro-developmental, molecular, neural and behavioural phenotypes associated with down or up regulation of specific circRNAs; 3) study the molecular mechanisms of action of circRNAs: identify circRNAs that work as miRNA sponges and determine whether circRNAs can encode proteins or act as signalling molecules and 4) perform mechanistic studies in order to determine cause-effect relationships between circRNA function and brain physiology and behaviour.
The present proposal will reveal the key pathways by which circRNAs control gene expression and influence neuronal function and behaviour. Therefore it will be one of the pioneer works in the study of this new and important area of research, which we predict will fundamentally transform the study of gene expression regulation in the brain";1971750;1971750;ERC-2014-CoG;ERC-COG;THE HEBREW UNIVERSITY OF JERUSALEM;IL;;; 194607;649660;Save at Work;SIGNED;H2020-EU.3.3.7.;EE-10-2014;H2020;save@work - The Energy Saving Contest for Public Authorities;1/02/2015;30/09/2017;;"save@work focusses on overcoming the barriers to energy saving practices in public office buildings and changing the behaviour of public sector employees at work place. A minimum of 9000 employees in at least 180 public office buildings (administrative buildings - municipal/regional or federal state operated) from nine countries will compete in a year-long energy saving contest to achieve the highest energy savings possible compared to the previous year. Throughout the competition participants will benefit from expert knowledge provided by the partners; a web-based Energy Saving Online Tool (feedback system) which helps to visualise actual energy consumption and savings made by each building; tailor made information and campaign materials and the exchange of experience with other participants. The energy saving competition between public office buildings is embedded in an energy quality management system: Analysis Development of Measures Implementation Monitoring and Continuation, which ensures an individual, professional goal-oriented and sustainable approach for realising energy savings.
It is projected that the project will lead to 13 GWh primary energy saved and 3,100 t of CO2 avoided in public buildings across Europe.

Support from behavioural change experts and an accompanying evaluation of the implemented measures and results will help provide important insights useful for both project implementation as well as future initiatives in this field. Factors of success, barriers and the impact of the project in respect to mid- and long-term changes will be analysed.
Project activities and results will be disseminated through a wide communication campaign to the public, as well as other stakeholders in public administrations and academic institutions. By providing a complete set of strategies and materials needed to replicate this project, our goal is to inspire others to follow our lead and develop energy efficient offices of the future.";1408990;1408990;H2020-EE-2014-3-MarketUptake;CSA;B. & S.U. BERATUNGS- UND SERVICE-GESELLSCHAFT UMWELT MBH;DE;"GRAZER ENERGIEAGENTUR GMBH;PRIORITERRE;ENERGIKONTOR SYDOST AB;EKODOMA;GREENDEPENDENT INTEZET NONPROFIT KOZHASZNU KORLATOLT FELELOSSEGU TARSASAG;SEVERN WYE ENERGY AGENCY LTD;AGENZIA PER L'ENERGIA E LO SVILUPPO SOSTENIBILE ASSOCIAZIONE;ARBEID & MILIEU VZW";"AT;FR;SE;LV;HU;UK;IT;BE"; 194570;649293;ProCold;SIGNED;H2020-EU.3.3.7.;EE-09-2014;H2020;ProCold: Empowering stakeholders to deliver highly energy efficient professional cold products;1/02/2015;31/01/2018;;"The general objective of the project is to empower private stakeholders and public authorities in adapting and enforcing EU and national energy efficiency policies in the sector of professional cold products.

A specific objective is to ensure more energy efficient professional cold products enter the EU market and increase their market shares, thereby contributing to the EUs energy efficiency goals and policies.

The product groups concerned relate to products cooling, refrigerating or freezing foodstuff and drinks in professional premises from public buildings, to hotels, retailers, and canteens. These represent significant energy consumption, important differences exist between various models of the same product category, but, due to lack of clear regulation and lack of information, the potential for more energy efficient models remains untapped.

The specific legislation concerned is the one regulating the minimum energy performance standards (Ecodesign) and energy labelling, as well as public procurement activities. The project benefits from ideal timing, since a number of the above mentioned product groups do not have an energy efficiency regulation in place, but these are planned to be developed and the project would therefore contribute to the knowledge of public authorities and policy makers on the specific performance characteristics of these product groups, based on which an effective legislation could be implemented and monitored.

Target groups of this project are threefold: empowering public authorities in implementing effective policies on energy efficiency of professional cold products; motivating product manufacturers and suppliers in delivering more efficient models to the market; and working with the food industry, retailers, building operators and other stakeholders in demanding and procuring more efficient professional cold products.";1178270,55;974671,8;H2020-EE-2014-3-MarketUptake;CSA;AGENCE DE L'ENVIRONNEMENT ET DE LA MAITRISE DE L'ENERGIE;FR;"SEVEN STREDISKO PRO EFEKTIVNI VYUZIVANI ENERGIE O.P.S.;OEKO-INSTITUT E.V. - INSTITUT FUER ANGEWANDTE OEKOLOGIE;GUIDE TOPTEN SARL;SVENSKA NATURSKYDDSFORENINGEN I;OSTERREICHISCHE ENERGIEAGENTUR AUSTRIAN ENERGY AGENCY;POLITECNICO DI MILANO;Quercus - Associao nacional de Conservao da natureza;BUSH ENERGIE GMBH";"CZ;DE;FR;SE;AT;IT;PT;CH"; 194545;648667;PQC;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Photonic Quantum Computing;1/06/2015;31/05/2020;;"This CoG will simultaneously address the outstanding research challenges to establishing the feasibility of large-scale photonic quantum computing by:

1. designing, fabricating and optimising the required hardware (WP1) componentsinc. waveguides, couplers, phase shifters, delays, interconnects, spectral filters, photon sources and detectors, and control electronics

2. establishing paths to the integration (WP2) of these components into complete systems

3. developing accurate, exhaustive and verified model of errors (WP3) in photonic quantum systems for optimised fault tolerance strategies, and efficient large-scale architectures (WP4)

4. exploring and developing approaches to optimising this architecture both generally, and for specific applications (WP5)

Addressing these challenges in parallel will be essential to realising the vision because interim outputs are required to address each challenge, and an iterative approach with the flexibility to redistribute resources and effort is necessary to reach an optimal solution in minimal time.";2009429;2009429;ERC-2014-CoG;ERC-COG;UNIVERSITY OF BRISTOL;UK;;; 194555;649053;BIZEB;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Bio-Imaging of Zoonotic and Emerging Bunyaviruses;1/04/2015;31/03/2020;;We aim to understand host cell entry of enveloped viruses at molecular level. A crucial step in this process is when the viral membrane fuses with the cell membrane. Similarly to cellcell fusion, this step is mediated by fusion proteins (classes IIII). Several medically important viruses, notably dengue and many bunyaviruses, harbour a class II fusion protein. Class II fusion protein structures have been solved in pre- and post-fusion conformation and in some cases different factors promoting fusion have been determined. However, questions about the most important steps of this key process remain unanswered. I will focus on the entry mechanism of bunyaviruses by using cutting-edge, high spatial and temporal resolution bio-imaging techniques. These viruses have been chosen as a model system to maximise the significance of the project: they form an emerging viral threat to humans and animals, no approved vaccines or antivirals exist for human use and they are less studied than other class II fusion protein systems. Cryo-electron microscopy and tomography will be used to solve high-resolution structures (up to ~3 ) of viruses, in addition to virusreceptor and virusmembrane complexes. Advanced fluorescence microscopy techniques will be used to probe the dynamics of virus entry and fusion in vivo and in vitro. Deciphering key steps in virus entry is expected to contribute to rational vaccine and drug design. During this project I aim to establish a world-class laboratory in structural and cellular biology of emerging viruses. The project greatly benefits from our unique biosafety level 3 laboratory offering advanced bio-imaging techniques. Furthermore it will also pave way for similar projects on other infectious viruses. Finally the novel computational image processing methods developed in this project will be broadly applicable for the analysis of flexible biological structures, which often pose the most challenging yet interesting questions in structural biology.;1998375;1998375;ERC-2014-CoG;ERC-COG;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;HELSINGIN YLIOPISTO;FI; 194747;651682;ProZero;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;ProZero - Carbon Based fast boats for professional use;1/10/2014;31/03/2015;;"The overall objective of the ProZero project is to overcome barriers and challenges connected to introducing carbon fibre boats on the fast boats market for professional use. The market has remained unchanged for decades and the introduction of a range of lightweight boats made out of carbon fiber would have a series of positive economic and environmental outcomes.
Tuco Marine Group ApS aims to pursue a major market opportunity by developing and commercializing carbon fibre boats for professional use. More specifically, Tuco aims to target 3 categories of boats: i) Fast Rescue Boats (FRB), ii) Daughter Crafts (DC - boats used for transport between mother ships and oilrigs or windmill parks), and iii) Work Boats (WB) designed with a deck for different work purposes. The objectives for the feasibility study (phase 1) are:
1. To perform a deep industry analysis, a market analysis and a mapping of internal capabilities in order to complete the business and project plan for carbon fibre FRBs, DCs and WBs.
2. To select and establish agreements with end-user for demonstration of carbon fibre boat.
3. To initiate the design of the whole ProZero Series including specifications for the boats, design of the necessary tools and moulds.
4. To initiate the development of a design portal and a non-disclosure-agreement for clients wanting to enter the portal.

Technological objectives to be accomplished during the innovation project (phase 2):
1. Design and develop moulds and tools for the scalable and cost-effective production of carbon fibre boats.
2. Showcase carbon based boats in operational use.
3. Develop the designs for a product range to complete the offering. The result will be a complete series of boats which can be built to order on the same platform, and thus without additional fix costs for each order.
4. Develop and implement a design portal, enabling customers to get access to the designs and drawings.";71429;50000;H2020-SMEINST-1-2014;SME-1;TUCO YACHT VRFT APS;DK;;; 194730;651490;Accellta;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.4.";BIOTEC-5a-2014-1;H2020;Accellta Market Study;1/11/2014;30/04/2015;;Human pluripotent stem cells (hPSCs) and hPSCs-derived differentiated cells, such as cardiomyocytes and neuronal cells, are rapidly advancing discoveries in drug screening and development processes and hold much promise for personalised regenerative medicine. The affordable mass production of industrial-grade high quality hPSCs will enable meeting the research and clinical demands of the rapidly growing stem cell market. Accellta Ltd. offers a range of innovative solutions for culturing mass quantities of premium quality stem cells in a cost-effective manner. These solutions are the result of research dated since 1998 at the Stem Cell Centre at the Technion Israel Institute of Technology. As a newly developed SME, this company has exceptional expertise in innovative hPSC culturing solutions, including growing stem cells in 3D suspension, with unique, animal-free reagents. These technologies are protected by numerous pioneering, granted and acknowledged patents and since its establishment in 2012. This SME already succeeded to license its IP to multi-national cell research companies. Accellta's future vision is to become a leading provider of premium quality differentiated cell lines and services to customers, which include pharmaceutical and biomedical companies. Despite the huge market potential, proper industry and market research plan is essential and organizing a professionally conducted study, using proper consultation and market research databases, is of the utmost importance. Understanding the market's direction and demands would provide the directives in which the company can proceed and find success. Accellta has the know-how, intellectual property, team and infrastructure required to emerge as a leader in this field. The company's remarkably unique techniques in pluripotent stem cell culturing would provide high quality hPSCs-derived differentiated cells will advance drug development and regenerative therapies.;71429;50000;H2020-SMEINST-1-2014;SME-1;ACCELLTA LTD;IL;;; 194634;649925;ingREeS;SIGNED;H2020-EU.3.3.7.;EE-04-2014;H2020;Setting up Qualification and Continuing Education and Training Scheme for Middle and Senior Level Professionals on Energy Efficiency and Use of Renewable Energy Sources in Buildings;1/03/2015;28/02/2018;;"The Project will extend the implementation of the Roadmap established and endorsed under Pillar I Build Up Skills project in Slovakia and the Czech Republic to middle and senior level professionals . These Roadmaps identified key measures for setting up a national qualification and training scheme and other measures for ensuring development of skills essential for the field of buildings to contribute to the fulfillment of the Europe 2020 energy targets. The project will particularly focus on key measure 1.3 and facilitate implementation of key measures 1.1, 1.2, 1.5 and 2.2 of the Roadmap endorsed in Slovakia, and on priority 4.3.1 and measures 1,2 and 4 of the Roadmap endorsed in the Czech Republic.

This will strengthen the qualification of professionals identified as target group in the Roadmaps . The project will facilitate further investments in the skills anticipated in the EU Roadmap to a Resource Efficient Europe .

Particularly the project will lead to:
Development of 5 education and training programmes for further education and training of middle and senior professionals in the field of buildings;
Setting up permanent network of trainers delivering the training programmes developed under the project;
Training of trainers for delivery of the programmes;
Proposal for financial measures to be established to facilitate and motivate middle and senior level professionals in participating to training programmes and SMEs to invest into further education;
Proposals to Slovak Government for incentives boosting demand for highly qualified professionals;
Reaching financing agreements using ESF for dissemination of training programmes.

The project will establish necessary resources and prepare technical, organizational and financial conditions for training and re-training on energy efficiency and use of renewable energy sources for middle and senior level professionals in the field of buildings.";1399622,72;1399622,72;H2020-EE-2014-3-MarketUptake;CSA;SLOVENSKA KOMORA STAVEBNYCH INZINIEROV;SK;"SEVEN STREDISKO PRO EFEKTIVNI VYUZIVANI ENERGIE O.P.S.;SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE;VIAEUROPA COMPETENCE CENTRE SRO;TECHNISCHE UNIVERSITAET GRAZ;Zvaz stavebnych podnikatelov Slovenska;SVAZ PODNIKATELU VE STAVEBNICTVI V CESKE REPUBLICE SDRUZENI;UNIVERSITAET FUER BODENKULTUR WIEN;NARODNY USTAV CELOZIVOTNEHO VZDELAVANIA";"CZ;SK;AT"; 194639;649997;Solar Bankability;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Improving the Financeability and Attractiveness of Sustainable Energy Investments in Photovolatics: Quantifying and Managing the Technical Risk for Current and New Business Models;1/03/2015;28/02/2017;;"The overall objective of this proposal is to reduce the risk associated with investments in sustainable energy projects. The project results should increase trust from investors, financers and insurance companies. The project aims to establish a common practice for professional risk assessment based on technical and financial due diligence. The focus is on photovoltaic (PV) installations, with emphasis on projects on buildings or at the customer side of the electricity consumption meter and financed by professional investors.

The project pursues the following specific objectives:
- To develop, document and establish practices for evaluating and mitigating the technical risks associated with investments in photovoltaics
- To develop, document and establish practices for valuing such risks when modeling the costs of a PV investment as investors do when evaluating the life cycle costs of such projects
- To evaluate how these risks affect the electricity production and the expected return on investment in different business models
- To enable the key actors, and particularly the financial market actors, to widely adopt the project results as best practices for the mitigation of risk of sustainable energy investments with current and new business models.

The project will be based on large amount of empirical data available within the consortium and from other projects, allowing to formulate recommendations that are statistically significant and based on a large evidence base.

The project will involve all relevant stakeholders being financial market actors, valuation and standardization entities, building and PV plant owners, industry, energy prosumers and policy makers. The impacts to be achieved are reduced uncertainty, increased investors confidence and trust, valuation methodologies agreed by the market, standardized descriptions of investments, labelling schemes or harmonized frameworks for investment, and support to national strategies for financing.";1355106;1355106;H2020-EE-2014-3-MarketUptake;CSA;ACCADEMIA EUROPEA DI BOLZANO;IT;"3E NV;ACCELIOS SOLAR GMBH;EPIA SOLARPOWER EUROPE AISBL;TUV RHEINLAND ENERGIE UND UMWELT GMBH";"BE;DE"; 194592;649532;EMU_SCEUS;SIGNED;H2020-EU.3.6.;EURO-1-2014;H2020;The Choice for Europe since Maastricht. Member States' Preferences for Economic and Financial Integration;1/07/2015;30/06/2019;;The Eurozone crisis corroborated the warnings of economists that weak economic policy coordination and loose fiscal oversight would be insufficient to stabilise the monetary union. To prevent a recurrence of the crisis, economists, political actors and the Blueprint of the European Commission are asking for the construction of a deep and genuine economic and monetary union with reinforced governance architecture beyond the recently adopted mechanisms. Many models of a fiscal union have been proposed and discussed. What is missing are not ideas and economic analysis, but the political consensus among member states governments for a specific integration path. Therefore, this political science project analyses the politics of economic and fiscal integration, that is, the conflict structure among member states. To this end, we aim to study the preferences of member states governments for different models of a fiscal union. Our theoretical framework builds on the comparative political economy literature and liberal intergovernmentalism and argues that domestic economic, fiscal and political factors are the main determinants of member states preferences. To empirically study the extent to which governments preferences are shaped by these factors, we propose to conduct 165 semi-structured interviews with decision makers in all member states. The interview data will be analysed with a mixed-method strategy including quantitative analysis as well as case studies. We fully expect that the findings of the project will provide guidance for the successful implementation of a feasible reform of the governance architecture of the EU to the effective stabilisation of the economy. In addition to the political feasibility analysis, we aim to study the legal context of potential integration scenarios. The consortium conducting this research covers all regions of the EU and consists of 8 distinguished political scientists and one legal scholar.;2290669;2150794;H2020-EURO-SOCIETY-2014;RIA;PARIS-LODRON-UNIVERSITAT SALZBURG;AT;"UNIVERSITY OF EAST ANGLIA;LUISS LIBERA UNIVERSITA INTERNAZIONALE DEGLI STUDI SOCIALI GUIDO CARLI;UNIVERSITAET BASEL;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;UNIVERSITAT KONSTANZ;KOZEP-EUROPAI EGYETEM;STOCKHOLMS UNIVERSITET";"UK;IT;CH;IE;FR;DE;HU;SE"; 194566;649261;FIRSTRUN;SIGNED;H2020-EU.3.6.;EURO-1-2014;H2020;Fiscal Rules and Strategies under Externalities and Uncertainties;1/03/2015;28/02/2018;;The FIRSTRUN project advances the theoretical and practical debates on the effective mechanisms of fiscal policy coordination. It analyzes the very reason why fiscal policy coordination may be needed in the first place, namely cross-country externalities (spillovers) related to national fiscal policies. Specifically, it identifies different types of spillover effects, investigates how they work in the EU and in the EMU, and analyses whether they work in the same fashion under different states of the economy and over the short and the long run. The project describes different forms that fiscal policy coordination can take in practice, e.g. ex-ante coordination and risk-sharing, and provides a critical assessment of the mechanisms already put in place. The FIRSTRUN project provides new tools for fiscal policy design by incorporating the new EU fiscal rules regarding e.g. government debt and deficit into applied models for fiscal policy evaluation. The tools can be used to support the decision makers in the implementation of the enhanced EU economic governance. FIRSTRUN also investigates the political economy of fiscal cooperation, for instance, the difficult inter-play between domestic political pressures and EU level priorities as well concerns about legitimation. By shedding light on the character of the governance framework for fiscal coordination, FIRSTRUN will highlight the features that work well or badly and provide insights that the EU level can exploit in its surveillance and advisory roles.;2197883;2197883;H2020-EURO-SOCIETY-2014;RIA;ELINKEINOELAMAN TUTKIMUSLAITOKSEN KANNATUSYHDISTYS RY;FI;"INSTITUT FUER HOEHERE STUDIEN - INSTITUTE FOR ADVANCED STUDIES;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;CENTRE FOR EUROPEAN POLICY STUDIES;LUISS LIBERA UNIVERSITA INTERNAZIONALE DEGLI STUDI SOCIALI GUIDO CARLI;EKONOMICKY USTAV SLOVENSKEJ AKADEMIE VIED;NATIONAL INSTITUTE OF ECONOMIC ANDSOCIAL RESEARCH LBG;CASE - CENTRUM ANALIZ SPOLECZNO- EKONOMICZNYCH- FUNDACJA NAUKOWA";"AT;UK;BE;IT;SK;PL"; 194578;649416;PARTISPACE;SIGNED;H2020-EU.3.6.;YOUNG-5a-2014;H2020;Spaces and Styles of Participation. Formal, non-formal and informal possibilities of young peoples participation in European cities.;1/05/2015;30/04/2018;;"Existing research suggests that political participation and European orientation of young people depend on how they experience influence and involvement at local level. This reflects that individuals need the experience of self-efficacy to engage in wider communities. Research also reveals that only few young people engage in formalised participation (parties, trade unions, or youth councils) as these are not flexible enough for individualised concerns, biographies and life styles and they reflect patterns of social inequality.
The project Spaces and Styles of Participation (PARTISPACE) starts from the assumption that all young people do participate while not all participation is recognised as such. The study asks for the different ways in which young people participate in decisions which concern them and, in general, the life of their communities. How do 15- and 30-year-olds engage with the public in formal, non-formal and informal settings and how is this supported or inhibited by local youth policies and youth work? The countries involved Bulgaria, France, Germany, Italy, Sweden, Switzerland, Turkey and the UK secure contrasting contexts of young peoples growing up as well as differing orientations towards Europe.
The design of PARTISPACE includes:
National research literature reviews and policy analysis;
Analysis of European Social Survey data on young peoples participatory orientations;
Local case studies in one major city per country including expert interviews, focus groups discussions, city walks and biographical interviews with young people, ethnographic case studies of formal, non-formal, and informal participatory spaces.
Activating and supporting participatory action research by young people themselves.
The analysis relates local constellations with national and European patterns and discourses of youth participation. Findings are constantly discussed with representatives of the youth sector at local and European level.";2575965;1985711;H2020-YOUNG-SOCIETY-2014;RIA;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;DE;"UNIVERSITE DE CERGY-PONTOISE;THE UNIVERSITY OF HUDDERSFIELD;Goeteborgs Universitet;THE MANCHESTER METROPOLITAN UNIVERSITY;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;NEW EUROPE CENTER FOR REGIONAL STUDIES SDRUZHENIE;YEDITEPE UNIVERSITY VAKIF;ECOLE DES HAUTES ETUDES EN SANTE PUBLIQUE;FHS ST. GALLEN HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN";"FR;UK;SE;IT;BG;TR;CH"; 194881;653511;RESOLVE;SIGNED;H2020-EU.3.4.;GV-5-2014;H2020;Range of Electric SOlutions for L-category VEhicles;1/05/2015;30/04/2018;;"RESOLVE proposal aims at enabling the development of a range of cost-effective, energy efficient and comfortable ELVs (Electric L-category Vehicles) that will primarily attract ICE car drivers to switch to ELVs for daily urban commutes.
EU cities are increasingly congested due to the demand and usage of motor vehicles that results in emissions and noise levels increase and scarcer parking, affecting the quality of life and health of city-dwellers. To tackle such issue, European-wide emission targets are becoming stricter and urban mobility plans are being drawn.
Future scenarios for EU urban centres see a modal shift in personal mobility from cars to lighter, smaller, more specialised and environmentally friendly alternatives.
ELVs are such alternatives that can cater to the average commuters needs because of their smaller size, lighter weight, lower on board energy requirement and thus smaller batteries, which supports lower costs and faster recharge.
However this modal shift has not been without challenges: many car drivers do not consider LVs as a viable and comfortable option.
To achieve that, the project will develop components and systems that meet the very low cost requirements for the segment, particularly modular and scalable LV-specific electric powertrains and battery architectures.
At the same time the project will deliver an exciting and attractive ELV driving experience by proposing new concepts (tilting & narrow track), while keeping the vehicle energy consumption at very low level.
All the advances will be demonstrated in two tilting four wheelers demonstrator ELVs (L2e and L6e category), though a large number of such advances will also be applicable to the complete range of ELVs (including powered-two wheelers).
The RESOLVE consortium is optimally positioned to drive such innovations: PIAGGIO and KTM are the 2 largest LV manufacturers in the EU and the whole ELV value chain is represented, complemented by top component suppliers and universities.";6920277;6844027;H2020-GV-2014;RIA;PIAGGIO & C S.P.A.;IT;"RICARDO DEUTSCHLAND GMBH;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;Robert BOSCH GMBH;RE:LAB S.R.L.;CESKE VYSOKE UCENI TECHNICKE V PRAZE;UNIVERSITA DI PISA;WAMTECHNIK SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA;UNIVERSITA DEGLI STUDI DI FIRENZE;THE UNIVERSITY OF WARWICK;KISKA GMBH;KTM MOTORRAD AG;IDIADA AUTOMOTIVE TECHNOLOGY SA;MAGNETI MARELLI S.P.A.";"DE;AT;IT;CZ;PL;UK;ES"; 194509;647557;SSBD;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Small Summaries for Big Data;1/05/2015;30/04/2020;;"A fundamental challenge in processing the massive quantities of information generated by modern applications is in extracting suitable representations of the data that can be stored, manipulated and interrogated on a single machine. A promising approach is in the design and analysis of compact summaries: data structures which capture key features of the data, and which can be created effectively over distributed data sets. Popular summary structures include the Bloom filter, which compactly represents a set of items, and sketches which allow vector norms and products to be estimated. These are very attractive, since they can be computed in parallel and combined to yield a single, compact summary of the data. Yet the full potential of summaries is far from being fully realized.

The Principal Investigator will lead a team, working on important problems around creating Small Summaries for Big Data. The goal is to substantially advance the state of the art in data summarization, to the point where accurate and effective summaries are available for a wide array of problems, and can be used seamlessly in applications that process big data. Several directions will be pursued, including: designing and evaluating new summaries for fundamental computations such as tracking the data distribution; summary techniques for complex structures, such as massive matrices, massive graphs, and beyond; and summaries that allow the verification of outsourced computation over big data. Success in any one of these areas could lead to substantial impact on practice, as evidenced by the influence of existing summary
techniques.

Support in the form of a five-year research grant will allow the PI to consolidate his research in this area, and build an expert team to focus on these challenging algorithmic questions.";1565502;1565502;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF WARWICK;UK;;; 194540;648527;DISTRUCT;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Structure Theory for Directed Graphs;1/07/2015;30/06/2020;;"Structural graph theory has proved to be a powerful tool for coping with computational intractability. It provides a wealth of concepts and results that can be used to design efficient algorithms for hard computational problems on specific classes of graphs that occur naturally in applications.

In many applications in computer science, the natural mathematical model are directed graphs. Unfortunately, research in structural graph theory has so far almost exclusively focussed on undirected graphs and no structure theory for directed graphs comparable to the tree-width and graph minors based approach for undirected graphs has been developed that would provide for a similar set of tools and concepts to deal with computational problems on directed graphs.

The objective of this proposal is to develop such a structure theory aimed specifically at algorithmic applications on directed graphs. The novelty of our approach is that:

a) it is based on directed minors which allows us to avoid the algorithmic problems faced by existing digraph width measures and has not been studied before in this context

and

b) it facilitates our recent proof of the excluded directed grid theorem which is likely to allow entirely new algorithmic techniques for directed graphs.

The focus of the project is on the development of the structural foundations and algorithmic techniques for designing efficient algorithms for a wide range of algorithmic digraph problems. In particular, we will use an approach based on logical definability for developing such algorithmic techniques.

Furthermore, we will apply our methods to two specific application areas, model-checking in computer-aided verification and inference problems in Bayesian networks.";1826773;1826773;ERC-2014-CoG;ERC-COG;TECHNISCHE UNIVERSITAET BERLIN;DE;;; 194858;653391;HDGAS;SIGNED;H2020-EU.3.4.;GV-7-2014;H2020;Heavy Duty Gas Engines integrated into Vehicles;1/05/2015;30/04/2018;;"The overall objective of HDGAS is to provide breakthroughs in LNG vehicle fuel systems, natural gas and dual fuel engine technologies as well as aftertreatment systems. The developed components and technologies will be integrated in up to three demonstration vehicles that are representative for long haul heavy duty vehicles in the 40 ton ranges. The demonstration vehicles will:
a) comply with the Euro VI emission regulations
b) meet at minimum 10% CO2 reduction compared to state of the art technology
c) show a range before fueling of at least 800 km on natural gas;
d) be competitive in terms of performance, engine life, cost of ownership, safety and comfort to 2013 best in class vehicles.

Three HDGAS engine concepts/technology routes will be developed:
- A low pressure direct injection spark ignited engine with a highly efficient EGR system, variable valve timing comprising a corona ignition system. With this engine a stoichiometric as well as a lean burn combustion approach will be developed. Target is to achieve 10% higher fuel-efficiency compared with state of the art technology
- A low pressure port injected dual fuel engine, a combination of diffusive and Partially Premixed Compression Ignition (PPCI) combustion, variable lambda close loop control and active catalyst management. Target is to achieve > 10% GHG emissions reduction compared with state of the art technology at a Euro VI emission level, with peak substitution rates that are > 80%;
- A high pressure gas direct injection diesel pilot ignition gas engine, that is based on a novel injector technology with a substitution rate > 90% of the diesel fuel. Target is to achieve same equivalent fuel consumption (< 215g/kWh) and 20% lower GHG emissions than the corresponding diesel engine.

HDGAS will develop all key technologies up to TRL6 and TRL7 and HDGAS will also prepare a plan for a credible path to deliver the innovations to the market.";27801977,81;19890587,5;H2020-GV-2014;IA;AVL LIST GMBH;AT;"DAIMLER AG;TECHNISCHE UNIVERSITAET GRAZ;Robert BOSCH GMBH;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;DINEX ECOCAT OY;RICARDO UK LIMITED;VOLVO TECHNOLOGY AB;Kompetenzzentrum - Das Virtuelle Fahrzeug, Forschungsgesellschaft mbH;FPT INDUSTRIAL;IVECO ESPANA SL;HOCHSCHULE ESSLINGEN;UNIRESEARCH BV;POLITECNICO DI MILANO;BORGWARNER LUDWIGSBURG GMBH;SAG MOTION GMBH;MAN TRUCK & BUS AG;ITA-SUOMEN YLIOPISTO;IDIADA AUTOMOTIVE TECHNOLOGY SA";"DE;AT;NL;FI;UK;SE;IT;ES"; 194530;648239;GLYCO-TOOLS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Bio-Inspired Tools for Glycoscience;1/07/2015;30/06/2020;;"Cell surface carbohydrates play key roles in cell recognition mechanisms. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer.

Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. This effect is known as the multivalency or clusterglycoside effect and has been well documented for lectincarbohydrate interactions as increasing ligand affinity and selectivity. The fundamental understanding of these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and several cancers to be defined, which will facilitate the identification of effective treatments and diagnostics for these conditions in due course.

This is a multidisciplinary project involving synthetic organic and inorganic chemistry, enzymology and glycobiology. The proposal centres on the development of expedient synthetic and chemo-enzymatic methodologies for the preparation of novel multivalent O-glycan probes that will be used in the screening of O-glycosylation-linked interactions in health and in disease. These studies will help us understand the parameters controlling the combinatorial diversity of O-glycans and the implications of such diversity on receptor binding and subsequent intracellular signalling, which in turn will lead us to the development of new glycan-based diagnostic tools and therapeutics.";1986356;1986356;ERC-2014-CoG;ERC-COG;UNIVERSITY OF BRISTOL;UK;;; 194451;646529;TILOS;SIGNED;H2020-EU.3.3.;LCE-08-2014;H2020;Technology Innovation for the Local Scale, Optimum Integration of Battery Energy Storage;1/02/2015;31/01/2019;;"TILOS aims to demonstrate the optimal integration of local scale energy storage in a fully-operated, smart island microgrid that will also communicate with a main electricity grid. The main objective of the project will be the development and operation of a prototype battery storage system, based on NaNiCl2 batteries, provided with an optimum, real-environment smart grid control system and coping with the challenge of supporting multiple tasks, ranging from microgrid energy management, maximization of RES penetration and grid stability, to export of guaranteed energy amounts and provision of ancillary services to the main grid. The battery system will support both stand-alone and grid-connected operation, while proving its interoperability with the rest of microgrid components, including demand side management aspects and distributed, residential heat storage in the form of domestic hot water.

At the same time, TILOS project addresses the high-priority area of the specific call concerning island regions. In doing so, apart from Tilos island, TILOS also engages the islands of Pellworm, La Graciosa and Corsica, aiming to create an island platform that will enable transfer of technological experience by making use of the smart grid system of Pellworm on the one hand, and by offering new case studies for the development of similar projects on the other. Elaboration of new case studies will be enabled by the development of an advanced microgrid simulating tool, i.e. the Extended Microgrid Simulator, offering the potential for the detailed examination of different battery technologies and microgrid configurations (stand-alone, grid connected and power market-dependent systems). Finally, by also addressing social issues, through public engagement, and by developing novel business models and policy instruments, TILOS puts emphasis on the market diffusion of the developed battery storage system and the integrated energy solution implemented on the island of Tilos.";13738569,58;11008622,5;H2020-LCE-2014-3;IA;Technological Educational Institute of Piraeus;EL;"FIAMM ENERGY STORAGE SOLUTIONS SRL;OPEN ENERGI LIMITED;EUNICE LABORATORIES AE;DIACHEIRISTIS ELLINIKOU DIKTYOU DIANOMIS ELEKTRIKIS ENERGEIAS AE;INSTITUTO TECNOLOGICO DE CANARIAS, S.A.;KUNGLIGA TEKNISKA HOEGSKOLAN;UNIVERSITY OF EAST ANGLIA;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SMA Solar Technology AG;UNIVERSITE DE CORSE PASCAL PAOLI;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;EUROSOL PROJEKT UND MANAGEMENT GMBH;YOUNICOS AG;WORLD WIDE FUND FOR NATURE GREECE;SCHLESWIG-HOLSTEIN NETZ AG";"IT;UK;EL;ES;SE;FR;DE"; 194732;651505;Direct Drive TT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Feasibility study for an innovative direct drive tidal turbine;1/10/2014;31/03/2015;;"Nova Innovation is a leading designer and manufacturer of tidal turbines. We have designed, built, deployed and are currently operating a grid-connected turbine in Scotland. In this project we will conduct a feasibility study into the market potential for our direct-drive tidal turbine design.

One way to reduce the cost and increase the reliability of tidal turbines is to find innovative ways to utilise the benefits of the subsea environment by using seawater to lubricate and cool the turbine drive train. Another is to reduce the number of offshore components by eliminating the gearbox to produce a direct-drive turbine. These steps reduce or eliminate the need for expensive and failure-prone equipment such as high pressure shaft seals, watertight bulkheads and cooling systems. This reduces operational costs and increases device reliability and yield.

No company to date has developed a direct drive tidal turbine that is reliable and economically viable. Our design is innovative in the particular combination of drive train, blade and support structure design, which is optimised to minimise the lifetime cost of the integrated system.

Potential customers are tidal energy project developers seeking to generate predictable, reliable energy from the tides at minimum lifetime cost. The market for tidal power is global, but Europe is taking a lead with potential clients in the UK, France and Ireland. Once proven in Europe the technology can be exported worldwide, with a potential global market of 800 TWh per annum (IEA-OES), or annual electricity sales of over 40 billion.

In Phase 1 we will conduct a feasibility study including a detailed IP review and strategy development, supply chain and market study and risk assessment to reinforce our business plan for exploiting this invention. In Phase 2 we will conduct a full-scale demonstration of the technology in a real-world setting: Nova Innovations existing, permitted, in-sea, grid-connected tidal energy site.";71429;50000;H2020-SMEINST-1-2014;SME-1;NOVA INNOVATION LTD;UK;;; 194551;648913;GAPS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Spectral gaps in interacting quantum systems;1/09/2015;31/08/2020;;"Interactions in a many body quantum system are encoded in a Hamiltonian, where the physical intuition that particles can only interact with those which are closeby is formally imposed as a local structure in the Hamiltonian, and homogeneity in space is imposed by a translational invariant structure on a given regular lattice in one, two or three dimensions. The first main aim of this proposal is to characterize the existence of a uniform (with the system size) lower bound on the gap between the two lowest eigenvalues of a given local translational invariant Hamiltonian.

There are many reasons which motivate this study, coming from different fields, and hence many potential applications. We will concentrate here on those coming from quantum information theory and from condensed matter physics and mainly, as the second main aim of this proposal, on classifying the different possible quantum phases arising in this type of models.";1462750;1462750;ERC-2014-CoG;ERC-COG;UNIVERSIDAD COMPLUTENSE DE MADRID;ES;;; 194624;649836;ICPEU;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Developing Protocols to standardize the development and documentation of energy efficiency projects in the built environment and accelerate their financing.;1/02/2015;31/01/2018;;"The importance of increasing investor confidence in energy efficiency as an asset class was stressed in a recent EU chartered Energy Efficiency Financial Institutions Group report which also highlighted the US based Investor Confidence Project as a relevant model and recommended an EU Investor Confidence Project. This project will deliver that Investor Confidence Project (ICP) to the EU.
Several studies document the potential energy savings for efficiency investments as well as the scale of the investment needed. BPIE estimated EUR937bn investment would be necessary in their Deep Scenario to achieve 78% energy savings and 90% CO2 savings.
Despite evidence of the potential attractiveness of investments, the flow of finance into energy efficiency remains much lower than required. Analysis reveals several barriers that hold private capital back but especially a lack of standardised processes and documentation, analogous to those used in the oil & gas and renewables industries. All financial markets are enabled by buyers and sellers agreeing standards. Scaling up investment in efficiency will require standardisation and greatly increased capacity in the financing market ICP Europe addresses these issues.
The project will work with key stakeholders to develop open source Protocols and apply them to real projects. The project has measurable KPIs but the real aim is to get commitment from investors that they will specify the use of the Protocols by project developers seeking finance making them standards.
The advantages of standardization, the adoption of the ICP in the US, and the high level of interest from EU investors that this pan-European multi-disciplinary consortium has already demonstrated lead us to believe that this is realisable objective within the 36 month project. A few key early financial adopters in each market will lead to wider adoption. We have already identified and engaged with a significant number of potential early adopters.";1912187,5;1912187,5;H2020-EE-2014-3-MarketUptake;CSA;ENERGYPRO LIMITED;UK;"THE ECOFIN RESEARCH FOUNDATION;RDA - CLIMATE SOLUTIONS UNIPESSOAL LDA;DNV KEMA LIMITED;PLUS ULTRA ASSET MANAGEMENT GMBH;VERCO ADVISORY SERVICES LIMITED;SERIMUS;DENKSTATT GMBH";"UK;PT;DE;LU;AT"; 194561;649180;NET4SOCIETY4;SIGNED;H2020-EU.3.6.;REFLECTIVE-10-2014;H2020;Transnational network of National Contact Points (NCPs) of Societal Challenge 6 'Europe in a changing world - inclusive, innovative and reflective Societies' (SC6);1/02/2015;31/01/2019;;"NET4SOCIETY4 will be the transnational network of National Contact Points (NCPs) for Societal Challenge 6 (SC6) Inclusive, innovative, and reflective societies in Horizon 2020. NCPs are set up to guide researchers in their quest for securing EU funding. NET4SOCIETY4 will further develop the current NET4SOCIETY network of SC6 NCPs (former NCPs for Socio-economic Sciences and Humanities), which was first established in 2008 and includes currently around 80 SC6 NCPs from Europe and beyond.

NET4SOCIETY4 will ensure that all SC6 NCPs have the relevant knowledge and skills for their work and can offer professional, high-quality and tailor-made services to applicants. All nominated SC6 NCPs (also non-beneficiaries) will have access to information and capacity building tools such as workshops, NCP Info days, trainings, webinars, factsheets or newsletters.

NET4SOCIETY4 foresees targeted activities to support applicants in SC6. The project will facilitate interdisciplinary and international consortium building through the organisation of brokerage events, through a dedicated partner search service and through a research directory of SC6 key players. In addition, NET4SOCIETY4 will organise expert meetings e.g. on impact of SC6 research and disseminate the meetings results to NCPs and applicants.

To support the successful implementation of embedding Socio-economic Sciences and Humanities (SSH) in all parts of Horizon 2020, NET4SOCIETY4 will carry out surveys on the integration of SSH in Horizon 2020. The project will publish success stories and factsheets on embedding, as well as a document listing funding opportunities for SSH in all of Horizon 2020.

NET4SOCIETY4 will organise two large conferences in the thematic area of SC6 to provide visibility to the funding programme and the possibility to discuss future research needs. Various promotion activities enhancing the visibility of NET4SOCIETY4 services and the SC6 in Horizon 2020 will underline these efforts.";3043489,37;2999989;H2020-REFLECTIVE-SOCIETY-2014;CSA;DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;DE;"FUNDACION ESPANOLA PARA LA CIENCIA Y LA TECNOLOGIA;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;THE ICELANDIC CENTRE FOR RESEARCH;IDRYMA PROOTHISIS EREVNAS;BELARUSIAN STATE UNIVERSITY;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;VEREIN EURESEARCH;CENTRUM VEDECKO TECHNICKYCH INFORMACII SLOVENSKEJ REPUBLIKY;ETHNIKO IDRYMA EREVNON;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;AGENCIA ANDALUZA DEL CONOCIMIENTO;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"ES;AT;IS;CY;BY;PL;FR;HR;CH;SK;EL;IT;PT"; 194494;647295;SYMBIOSYS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Symbolic Analysis of Temporal and Functional Behavior of Networked Systems;1/08/2015;31/07/2020;;"The goal of SYMBIOSYS is to assure the reliability and interoperability of networked (software) systems, a crucial requirement in todays networked information society. To this end, we devise a software and systems analysis methodology that for the first time considers the vital influence factors that determine the behavior of networked systems, especially including input and temporal uncertainty of network interactions. With SYMBIOSYS, we will be able to automatically
and effciently explore and analyze the vast amount of distributed execution paths in networked systems in a highly structured manner inspired by Symbolic Execution (SE).

The combination of the benefits of model checking (rigorous exploration) and of dynamic software testing (analyzing real systems code) represents a quantum leap in the field of network analysis. Orthogonal to and complementing formal model-based approaches, which target the design of reliable systems on an abstract (model-) level, we also address system- and
implementation-level aspects of (typically heterogeneous) implementations that interact via unpredictable networks. To achieve this, we introduce the fundamentally new approaches Symbolic Distributed Execution (SDE), Symbolic Temporal Execution (STE) and their symbiosis (SDTE). This is a breakthrough in the symbolic analysis of real systems and significantly widens the scope of SE to new analysis domains.

Our novel approach raises the issue of complexity and path explosion. Yet, our experience from early work on SDE strongly suggests that the use of domain-specific knowledge and further general optimization strategies allow to significantly reduce this complexity and enable an efficient analysis. SYMBIOSYS also enables and fosters the design of new methods and tools to ensure reliability, interoperability, and other vital properties of networked systems. We demonstrate our new methodology through examples from Cyber-Physical Systems and low-latency communication.";1988750;1988750;ERC-2014-CoG;ERC-COG;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;DE;;; 194525;648229;CNT-QUBIT;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Carbon Nanotube Quantum Circuits;1/09/2015;31/08/2020;;"The aim of this proposal is to use spin qubits defined in carbon nanotube quantum dots to demonstrate measurement-based entanglement in an all-electrical and scalable solid-state architecture. The project makes use of spin-orbit interaction to drive spin rotations in the carbon nanotube host system and hyperfine interaction to store quantum information in the nuclear spin states. The proposal builds on techniques developed by the principal investigator for fast and non-invasive read-out of the electron spin qubits using radio-frequency reflectometry and spin-to-charge conversion.

Any quantum computer requires entanglement. One route to achieve entanglement between electron spin qubits in quantum dots is to use the direct interaction of neighbouring qubits due to their electron wavefunction overlap. This approach, however, becomes rapidly impractical for any large scale quantum processor, as distant qubits can only be entangled through the use of qubits in between. Here I propose an alternative strategy which makes use of an intriguing quantum mechanical effect by which two spatially separated spin qubits coupled to a single electrical resonator become entangled if a measurement cannot tell them apart.

The quantum information encoded in the entangled electron spin qubits will be transferred to carbon-13 nuclear spins which are used as a quantum memory with coherence times that exceed seconds. Entanglement with further qubits then proceeds again via projective measurements of the electron spin qubits without risk of losing the existing entanglement. When entanglement of the electron spin qubits is heralded which might take several attempts the quantum information is transferred again to the nuclear spin states. This allows for the coupling of large numbers of physically separated qubits, building up so-called graph or cluster states in an all-electrical and scalable solid-state architecture.";1998574;1998574;ERC-2014-CoG;ERC-COG;UNIVERSITY COLLEGE LONDON;UK;;; 194577;649397;R4E;SIGNED;H2020-EU.3.3.7.;EE-07-2014;H2020;Roadmaps for Energy;1/03/2015;28/02/2018;;"Within the Roadmaps for Energy (R4E) project the partners will work together to develop a new type of energy strategy through visions and roadmaps for the 8 partner cities, in co-creation with local stakeholders. The stakeholders include the benefactors of the strategy, such as citizens, as well as relevant research and industry partners, to offer a clear picture of the future potential of the city.
In the R4E project a four step process is applied. The FIRST step sets the ambitions for the project. The ambitions of the participating cities on sustainable energy and Smart Cities in general are set, as well as the partner cities' choice for 2 focus areas within Smart Energy Savings: 1.Smart Buildings, 2. Smart Mobility or 3. Smart Urban Spaces. The SECOND step is to develop desired scenarios for the cities for the selected focus areas. During the THIRD step the roadmap will be created, existing and future technologies and other developments will be identified, which enable the realization of the desired future scenarios. Opportunities and developments will be plotted on a timeline to provide insight in the required steps and milestones towards the favoured scenarios. The roadmaps will contain generic parts that are common for the partner cities, as well as specific parts that cater for the specific context of the cities. During the final and FOURTH step a project portfolio will be generated with new projects and initiatives to reach the ambitions, visions and roadmaps of the cities. This portfolio provides an overview of individual and joint projects and includes a cross-city learning plan and a financial plan.
At the end of the project each partner city will each have 2 future scenarios, 2 roadmaps and a portfolio of individual and joint projects to implement sustainable energy policies and measures. Also the visioning and roadmapping capacities within the municipalities are developed to spur future development and implementation of innovative energy solutions.";1999840,25;1999840;H2020-EE-2014-3-MarketUptake;CSA;GEMEENTE EINDHOVEN;NL;"AJUNTAMIENTO DE SANT CUGAT DEL VALLES;COMUNE DI PALERMO;AYUNTAMIENTO DE MURCIA;Istanbul Metropolitan Municipality;NEWCASTLE CITY COUNCIL;COMUNE DI FORLI;UNIVERSITAT POLITECNICA DE CATALUNYA;TALLINNA KESKKONNAAMET;TECHNISCHE UNIVERSITEIT EINDHOVEN";"ES;IT;TR;UK;EE;NL"; 194715;651203;PRECEDE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;PRECEDE: PancREatic Cancer Early DEtection;1/10/2014;31/03/2015;;"PRECEDE (PancREatic Cancer Early DEtection): Pancreatic cancer is a devastating disease. Five year survival is only 3% and this figure has not changed for 40 years. A recent EU study has shown that this is the only cancer whos incidence and mortality are set to increase. By the time patients present with symptoms, the disease is usually advanced and untreatable. The most effective way to improve survival would be to diagnose the disease earlier when therapy is more likely to be successful.
CA19.9 is an approved biomarker for aiding diagnosis of pancreatic cancer in symptomatic individuals. Its sensitivity and specificity are not high enough for screening healthy high risk individuals due to the high number of false positives caused by the natural variation in levels within a population. Abcodia has developed an algorithm that learns an individuals healthy baseline of CA19.9 and spots any inflection point as pancreatic cancer develops. This personalisation of the CA19.9 test increases sensitivity by identifying low but increasing values, improves specificity by discounting high but flat profiles and detects the disease earlier through regular testing and spotting inflection points.
Abcodia has developed the algorithm based on longitudinal pre-diagnosis levels of CA19.9 levels from 64 pancreatic cancer cases and 161 healthy controls from the UK Collaborative Trial in Ovarian Cancer Screening, which for over 10 years monitored the health of 202,000 initially free from cancer women. The algorithm improves the performance of the marker CA19.9 and detects the disease earlier than standard diagnostic practice. The algorithm now requires clinical validation in a population based clinical trial across Europe to allow full commercialisation.
This phase 1 project will build a robust business plan for the validation and commercialisation of one of the first examples of a personalised screening diagnostic that aims to finally improve survival in this devastating disease.";71429;50000;H2020-SMEINST-1-2014;SME-1;ABCODIA LIMITED;UK;;; 194843;653284;GelSwimming;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;Bacterial motion in polymer solutions and biogels;26/02/2016;25/02/2018;;Many cavities in the human body such as the lungs, the stomach or the reproductive tract are covered and protected by a thin layer of mucus gel. Under certain conditions pathogenic bacteria are able to penetrate the mucus layer which leads to serious infections. For example, in cystic fibrosis motile bacteria swim through the mucus layer and form biofilms which can be resistant to antibiotic medication. Interestingly, corals in the ocean are also covered by mucus. Again, pathogenic bacteria are able to penetrate the coral mucus layer and cause serious diseases resulting in a world-wide decline of corals. The underlying mechanisms how the bacteria are able to move through mucus are not yet understood. We aim, in our proposal, to clarify physical conditions under which bacterial locomotion in polymer solutions and gels is possible. In contrast to existing theories on swimming in viscoelastic fluids we explicitly model the gel and the bacteria via mesoscale computer simulations. Our novel approach will enable us to identify the microscopic conditions for bacterial locomotion in gels and the conditions for immobility (gel-trapping). Our findings may also inspire biologists and medical researchers in designing novel medication and finding strategies to avoid bacterial invasion into mucus of relevance to both the prevention of human disease and the degradation of corals.;195454,8;195454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194515;647895;gluactive;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Activation Mechanism of a Glutamate Receptor;1/07/2015;30/06/2020;;Glutamate receptors are amongst the most important signalling molecules in the brain. Activation of receptors by the neurotransmitter glutamate is required for nervous system function, underlying cognition, learning, memory and sensation. Despite advances in the study of their structural biology and physiology, how glutamate receptor complexes are activated remains unclear. With this proposal, we aim to determine how receptor activation and desensitisation are driven by glutamate binding. Our central approach is to map the motions of glutamate receptors during synaptic-like activity, in order to grab the frames needed to produce the movie of receptor activation. We aim to detect motion within the receptor on the angstrom scale by trapping conformational states during activation with artificial metal ion binding sites and disulfide bonds. Trapped receptors will be examined using biochemical measures of subunit association, biophysical reports of receptor activity and by structural biology. The results we obtain will be useful to rationally interfere with excitatory synapses in the brain and may therefore help the development of therapies.;1981500;1981500;ERC-2014-CoG;ERC-COG;FORSCHUNGSVERBUND BERLIN E.V.;DE;;; 194619;649773;MEnS;SIGNED;H2020-EU.3.3.7.;EE-04-2014;H2020;Meeting of Energy Professional Skills;1/03/2015;31/08/2017;;"MENS is a project conceived in order to provide an enhance the NZEB skills of building managers such as engineers and architect through a series of accredited training activities developed by 9 universities and 3 market players. MENS aims:
- To increase the knowledre and skills of at least 1800 building managers (engineers, architects) in NZEB design and construction, out of which 50% would be women or unemployed.
- To create and implement a new education and training program for such professionals in 10 countries, under the European Qualifications Framework provisions and based on desired and common learning outcomes of Level 7.
- To create and implement an innovative, interdisciplinary education and training program with an integrated approach, focusing on real case studies
- To accredit courses using the formal procedure in each country and assign ECTS credits.
- To enhance and support the development of a professional network in Europe specifically focused on retrofitting of housing stocks towards NZEB. A connection with over 250,000 stakeholders and market players.
- To provide working opportunities to unemployed professionals, by bringing them closer to possible employers and improving their qualifications, at a percentage of 30% of those attending.
- To continue the education and training courses for at least 5 years after the end of the project based on concrete sustainability plans agreed by University partners.
- To result in energy savings and/or increased use of renewables of at least 28,96 GWh/year.
MENS is developed through 3 sets of training activities: national accreditation professional courses; e- learning and webinars: and case studies experiences around Europe and it involves involves major universities and stakeholders either directly or as Associated Partners engaged with LOS. MENS finally benefits from a strong media promotional activity through a wide network of local TVs and RTBF.";1478160;1478160;H2020-EE-2014-3-MarketUptake;CSA;ENERGIA-DA SRL;IT;"INSTITIUID TEICNEOLAIOCHTA BHAILE ATHA CLIATH;ARISTOTELIO PANEPISTIMIO THESSALONIKIS;RADIO-TELEVISION BELGE DE LA COMMUNAUTE FRANCAISE;Ss. CYRIL AND METHODIUS UNIVERSITY IN SKOPJE;UNIVERSITE LIBRE DE BRUXELLES;UNIVERSITAET KASSEL;ENERGY CONSULTING NETWORK APS;KNOWLEDGE TRANSFER NETWORK LIMITED;UNIVERSITAT POLITECNICA DE VALENCIA;BRUNEL UNIVERSITY LONDON;UNIVERSITY OF CYPRUS;UNIVERSITATEA TEHNICA CLUJ-NAPOCA";"IE;EL;BE;MK;DE;DK;UK;ES;CY;RO"; 194563;649189;InnoSI;SIGNED;H2020-EU.3.6.;EURO-3-2014;H2020;Innovative Social Investment: Strengthening communities in Europe (InnoSI);1/05/2015;31/10/2017;;"There is growing consensus in Europe that an active set of approaches to welfare known as Social Investment will improve human capital, enable more people to participate in society, and reduce intergenerational deprivation, yet implementation has been uneven across member states and much remains to be learned, especially with regard to regional and local realities of Social Investment. This proposal is for EURO-3-2014: European societies after the crisis. Within that call its focus is on Innovative social investment approaches for the modernisation of social policies and services. We will deploy multidisciplinary research on innovative ways of implementing and financing social welfare that promise lasting benefits. Our aims are threefold:
-Identify and evaluate existing innovative and strategic approaches to social welfare reform at a regional and local level;
-Explore social and psychological impact of these innovations on individuals and communities;
-Collate useful, practical learning from this new body of evidence and mobilise it to inform policy and practice across the EU.
We will deliver on our first two aims through:
Macro and micro-level research on social investment policies and initiatives;
Mixed method case studies in ten member states, taking account of local and regional networks, institutions and assets, as well as national and European policies;
A distinct understanding of Social Investment utilizing social innovation as a key concept;
A strong user voice, ensured throughout the project by recruiting and training Community Reporters

Approximately a third of the resource on this project is devoted to impact generation (Aim 3). Results from the research will be assimilated in a Foresight Analysis where we will work with policy makers, user-led organizations and social entrepreneurs to consider options for innovative ways of implementing and financing social welfare systems in the future. 10 impact partners will assist us.";2375832,75;2375832,25;H2020-EURO-SOCIETY-2014;RIA;THE MANCHESTER METROPOLITAN UNIVERSITY;UK;"FUNDACJA INSTYTUT SPRAW PUBLICZNYCH;INSTITOUTO ERGASIAS;A.I.C.CO.N.;PANTEIO PANEPISTIMIO KOINONIKON KAIPOLITIKON EPISTIMON;DEBRECENI EGYETEM;EUCLID NETWORK;FUNDACION TECNALIA RESEARCH & INNOVATION;PEOPLE S VOICE MEDIA LBG;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER;FORUM - IDEBURNA ORGANISATIONER MED SOCIAL INRIKTNING;Stichting Hogeschool Utrecht;TURUN AMMATTIKORKEAKOULU OY;UNIWERSYTET WROCLAWSKI;UNIVERSITAT POLITECNICA DE VALENCIA;LOCALITY (UK) LBG;KARLSTADS UNIVERSITET";"PL;EL;IT;HU;UK;ES;DE;SE;NL;FI"; 194717;651230;IPCC;SIGNED;H2020-EU.3.5.;Environment;H2020;Support for the Intergovernmental Panel on Climate Change (IPCC) to facilitate the preparation of its next Assessment Report;1/05/2015;30/04/2020;;The Intergovernmental Panel on Climate Change (IPCC) is the key global climate science-policy interface, underpinning European and international climate change policy-making and is the leading global body responsible for the scientific assessment of climate change. In preparation of the next Assessment Report, support will be provided to increase the participation of experts from developing countries and EU countries, should their governments be unable to provide appropriate funding, consistent with IPCC practices, to the IPCC process and enhance visibility of the IPCC goals in Europe.;2634537,5;700000;H2020-Adhoc-2014-20;CSA;ORGANISATION METEOROLOGIQUE MONDIALE;CH;;; 194435;646453;ENSCC;SIGNED;H2020-EU.3.3.2.;LCE-18-2014;H2020;ERA-NET Smart Cities and Communities;1/12/2014;30/11/2019;;"'Smart Cities and Communities have been identified as key to achieving the energy efficiency targets for 2020 and 2050. The main objective of this ERA-NET is to stimulate successful practice and facilitate replicability within Smart Cities and Communities projects and also across projects in order to achieve a technological shift in the current energy system and provide smart and integrated solutions for technology, government and society. ERA-NET Smart Cities and Communities aims to create solutions in the form of projects, which demonstrate or at least constitute a decisive step towards implementations that
(1) help cities deal with a long uncertain time horizon,
(2) monitor ongoing experiences and implement change in the project when necessary, and
(3) avoid pitfalls already encountered by others and facilitate collective learning of stakeholders embedded within a physical and social context.
Additional activities within the planned ERA-NET are: (A) to work towards a joint call with China and (B) to align national R&D funding with Structural Funds. (A): A structured and systematic approach towards a joint call with China on smart city research will be developed making highest use of existing relations, activities and experience of European Funding Agencies with Chinese partners in order to develop a joint call with China. Beneficiaries of this call (mainly research organisations and companies) would be given a good starting position for further research and development projects. (B) The realisation of smart cities measures requires large investment volumes. Thus, the combination and clustering of different financing instruments is necessary. In line with the new 'smart specialization' strategy of the EC, the proposed additional activities should encourage and enable Member States, regions and their Managing Authorities to align their national R&D funding schemes with available Structural Funds (in particular ERDF, but also ESF resources).'";21925020,07;6428753,43;H2020-LCE-2014-3;ERA-NET-Cofund;BUNDESMINISTERIUM FUER VERKEHR, INNOVATION UND TECHNOLOGIE;AT;"FEDERAL DEPARTMENT FOR ENVIRONMENT TRANSPORTS ENERGY AND COMMUNICATION;INNOVAATIORAHOITUSKESKUS TEKES;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;NEDERLANDSE ORGANISATIE VOOR WETENSCHAPPELIJK ONDERZOEK;IDRYMA PROOTHISIS EREVNAS;STATENS ENERGIMYNDIGHET;VERKET FR INNOVATIONSSYSTEM;Ministerul Educatiei Nationale;SERVICE PUBLIC DE WALLONIE;NORGES FORSKNINGSRAD;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;Institut pour l'Encouragement de la Recherche scientifique et de l'Innovation de Bruxelles;FONDS NATIONAL DE LA RECHERCHE SCIENTIFIQUE;FORSKNINGSRDET FR MILJ, AREELLA NRINGAR OCH SAMHLLSBYGGANDE;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"CH;FI;AT;NL;CY;SE;RO;BE;NO;TR;ES;PT"; 194868;653450;SEREN 3;SIGNED;H2020-EU.3.7.;DRS-08-2014;H2020;Security Research NCP Network 3;1/05/2015;30/04/2018;;"SEREN3 is a 36-month Coordination and Support Action with the overall aim of facilitating trans-national co-operation among NCPs for Secure Societies, identifying and sharing good practices, and raising the general standard of the support to programme applicants across the EU, Associated and Third countries. To reach the objective above, the project will develop three main activity axes, corresponding to the projects specific objectives: 1) capacity building of NCPs; 2) strengthening the participation of relevant stakeholders to Horizon 2020 funding opportunities; 3) and supporting networking opportunities within the Secure Societies constituency. Cross-cutting activities of dissemination and communication will addup to this main set of activities, helping to enhance their impact.
SEREN3 is the continuation and evolution of the precedent network, SEREN2, whose results and lessons learnt have been taken into consideration with the logic of improving the future network and in order to valorize the networks strengths. SEREN3 will also take into account the paradigmatic change brought by Horizon 2020. This will be reflected in particular in a stronger attention of the network in terms of multidisciplinary competences, consideration of related societal challenges, and linkage with other EU relevant initiatives, funding programmes and policies. Finally, the network will seek further opening to a wider target of stakeholders and businesses in the Secure Societies field.
SEREN3 consortium comprises 17 beneficiaries, with a good mix of well-experienced and less experienced NCPs, and representing Member States, Associated Countries and Third Countries. Besides beneficiaries, the project services will be offered to all officially appointed H2020 Secure Societies NCPs, who will be involved as associated partners.";1995451,02;1995451;H2020-DRS-2014;CSA;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;IT;"COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH;SIHTASUTUS EESTI TEADUSAGENTUUR;THE ICELANDIC CENTRE FOR RESEARCH;IDRYMA PROOTHISIS EREVNAS;TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY;AGENCE BRUXELLOISE POUR L'ENTREPRISE;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;ROMANIAN SPACE AGENCY;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;RIGAS TEHNISKA UNIVERSITATE;DIENST VOOR WETENSCHAPPELIJKE EN TECHNISCHE INFORMATIE- SERVICE D'INFORMATION SCIENTIFIQUE ET TECHNIQUE;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;CENTRUM VEDECKO TECHNICKYCH INFORMACII SLOVENSKEJ REPUBLIKY;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;MATIMOP - THE ISRAELI CENTER FOR R&D";"ZA;EE;IS;CY;CZ;BE;EL;RO;PL;LV;HR;SK;TR;ES;IL"; 194536;648432;MEMBRANEFUSION;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Structure and mechanism of viral and cellular membrane fusion machineries;1/09/2015;31/08/2020;;Fusion of two biological membranes is essential to life. It is required during organism development, for trafficking of material between cellular compartments, for transfer of information across synapses, and for entry of viruses into cells. Fusion must be carefully controlled and the core fusion components are typically found within a complex regulatory machine. There have been decades of research on the structure and function of individual components, on the dynamics and biophysics of fusion, and on phenotypes resulting from mutating or inhibiting component proteins. These have led to a model for fusion in which regulated refolding or assembly of proteins draws two membranes closer together until they fuse. Despite this breadth of study, we know very little about how the components of the fusion machinery function in context: How are they arranged on the membrane around the site of fusion? How do they respond structurally to regulation? How does the fully assembled machinery rearrange to reshape the membrane and drive fusion? These gaps in knowledge can be attributed to a shortage of structural biology methods able to derive structural data on proteins assembled within complex, heterogeneous or dynamic environments such as a fusion site. Here I propose to apply a combination of state-of-the-art cryo-electron tomography, image processing and correlative fluorescence and electron microscopy methods to obtain detailed structural information on assembled fusion machineries and of fusion intermediates both in vitro and in vivo. I will study how influenza virus fuses with a target membrane, complemented by studies on fusion of HIV-1 and of synaptic vesicles. By determining how viral and synaptic fusion complexes reposition and restructure prior to fusion, how they arrange around the fusion site, how they reshape the membrane to induce fusion, and how these processes can be regulated and inhibited, I will derive a mechanistic model of membrane fusion in situ.;1965961;1965961;ERC-2014-CoG;ERC-COG;MEDICAL RESEARCH COUNCIL;UK;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE; 194546;648709;Clock Mechanics;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Mechanosensation and the circadian clock: a reciprocal analysis;1/09/2015;31/08/2020;;"All forms of life adjust themselves to the daily rhythms of their environments using endogenous oscillators collectively referred to as circadian clocks. Peripheral and central body clocks exist, which both require extrinsic information (e.g. light or temperature changes) to keep in sync with the geophysical cycle (entrainment). In addition, intrinsic cues (e.g. activity levels) have been linked to clock entrainment. Recently, we could show that activation of proprioceptors is sufficient to entrain the central clock of the fruit fly Drosophila melanogaster. Proprioceptors are mechanosensors that monitor the positions, and relative movements, of an animals own body parts. The existence of proprioceptive entrainment pathways has significant implications; it implies that an animals clock time is computed by integrating, and weighting, various external and internal conditions, suggesting the existence of external and internal time.
Using Drosophila, I will investigate the relationship between mechanosensory and circadian systems in a dual, and bidirectional, approach. The projects first aim is to dissect the neurobiological bases of proprioceptive clock entrainment (i) identifying the specific stimulus requirements for effective entrainment, (ii) determining its mechanosensory pathways and, in a combined computational and experimental strategy, (iii) quantifying the precise contributions of an animals activity to its sense of time. The projects second aim, in turn, is to unravel the roles of the clock, and clock genes, for the function of mechanosensory systems. Previous studies have linked the clock to noise vulnerability in mammalian ears, and clock genes to regeneration in avian ears. Our own preliminary data reveal severe mechanosensory defects in flies mutant for core clock genes. I will use the Drosophila ear as a unifying model to analyse the specific roles of the clock, and clock genes, for the function of mechanotransducer systems.";1899549;1899549;ERC-2014-CoG;ERC-COG;UNIVERSITY COLLEGE LONDON;UK;;; 194479;647019;CHILE;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;A Comparative History of Insurance Law in Europe;1/09/2015;31/08/2020;;"The objective of the project is to work out interactions between the national developments of insurance law in Europe, to explore the possibility of common historical roots of European insurance law, and to reassess the history of insurance law in Europe. The project does, thereby, aim at creating a historical basis for a European legal scholarship in the field of insurance law.

Todays state of research in the field of the history of insurance law is unsatisfactory: with the exception of maritime insurance, modern research focuses on national developments and the history of insurance law is told differently in the European countries. Even though modern research suggests that there have been interactions between the national developments these interactions often appear to be only footnotes to a mainly national development.

For the first time, the project takes these points of interactions as a starting point for an in depth research into the history of insurance law in Europe. It is, to take an example involving England and Germany, known that English life and fire insurers where present on the German market since the late 18th century and that those who, in the beginning of the 19th century, were involved in founding the first commercial life and fire insurers in Germany had been working for English insurers. What needs to be explored is what impact this had on the practice and standard contract terms of German insurers. On the basis of the research into this and other points of interactions it will, for the first time, be possible to research into the doctrinal history of insurance law on a European level.

The project will help to reassess the history of insurance law in Europe and it will create a historical basis for a European scholarship in the field of insurance law: the harmonization of European insurance contract law is on the agenda. Comparative historical research will help to understand the existing differences between the insurance laws in Europe.";1992500;1992500;ERC-2014-CoG;ERC-COG;UNIVERSITAET AUGSBURG;DE;;; 194500;647390;EXPLORINGMATTER;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Exploring Matter with Precision Charm and Beauty Production Measurements in Heavy Nuclei Collisions at LHCb;1/04/2015;31/03/2020;;"Collisions of ultra relativistic nuclei are a tool to reach huge energy densities and to form a new state of matter called Quark-Gluon Plasma (QGP), where quarks and gluons can move freely. A number of experiments have studied the possible formation of QGP, but the behaviour of heavy particles such as charm (c) and beauty (b) quarks when they traverse this medium is largely unknown and is the most powerful tool to prove the creation of the QGP and to characterise it. I will perform novel measurements using the LHCb detector at CERN, which covers an unique kinematic region, essential for a full understanding of QGP and nuclear matter in general. LHCb has been optimised to perform c and b quark physics measurements in proton-proton collisions. In EXPLORINGMATTER I propose to extend the LHCb programme to collect for the first time data in heavy ion collisions. Three experimental scenarios are foreseen: (1) Collisions of protons, benchmark to understand the behaviour of the c and b particles in other more complicated environments, as well as providing the final answers to the mechanism of heavy quarkonium production; (2) Collisions of protons with heavy nuclei, where cold nuclear matter effects in high-energy collisions can be studied in detail to understand lead nuclei collisions, where QGP is expected to be formed. (3) Collisions of heavy nuclei, pursued (a) by analysing heavy nuclei interactions through a dedicated setup in which gas will be injected in the LHCb interaction region, reaching energy densities typical of dedicated fixed target experiments; (b) by collecting heavy ion collision data at the LHC. This second setup, which has not been envisaged by LHCb up to now will revolutionise the measurements in this area thanks to the LHCb coverage and precision not achievable by any other experiment. My measurements will furthermore indicate the route to new experiments that could be designed on the basis of these findings.";1849957;1849957;ERC-2014-CoG;ERC-COG;UNIVERSITA DEGLI STUDI DI CAGLIARI;IT;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR; 194510;647678;CC;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Combinatorial Construction;1/01/2016;31/12/2020;;"Combinatorial Construction is a mathematical challenge with many applications. Examples include the construction of networks that are very sparse but highly connected, or codes that can correct many transmission errors with little overhead in communication costs. For a general class of combinatorial objects, and some desirable property, the fundamental question in Combinatorial Construction is to demonstrate the existence of an object with the property, preferably via an explicit algorithmic construction. Thus it is ubiquitous in Computer Science, including applications to expanders, sorting networks, distributed communication, data storage, codes, cryptography and derandomisation. In popular culture it appears as the unsolved 'lottery problem' of determining the minimum number of tickets that guarantee a prize. In a recent preprint I prove the Existence Conjecture for combinatorial designs, via a new method of Randomised Algebraic Constructions; this result has already attracted considerable attention in the mathematical community. The significance is not only in the solution of a problem posed by Steiner in 1852, but also in the discovery of a powerful new method, that promises to have many further applications in Combinatorics, and more widely in Mathematics and Theoretical Computer Science. I am now poised to resolve many other problems of combinatorial construction.";1706729;1706729;ERC-2014-CoG;ERC-COG;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK;;; 194702;651007;PneumoSIP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;PneumoSIP a cost-effective solution for the rapid diagnostic of pneumonia;1/10/2014;28/02/2015;;"Despite significant advances in sanitation and medicine, infectious diseases still annually claim in excess of 15 million lives. Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. Pneumonia is also the leading cause of death in children worldwide. It kills an estimated 1.6 million children under the age of five every year, about 25% of all pediatric deaths around the world more than AIDS, malaria and tuberculosis combined. In the EU about 3.3 million cases are reported annually with hospitalization rates ranging from 2050%, meaning that there are about 1 million hospital admissions for CAP per year in the EU. In addition, the growing resistance to antibiotic treatments (>10% in EU), makes pathogen identification and streamlining of antibiotic treatment even more important.
AlphaSIP aims the development of a cost-effective solution for the rapid diagnostic of pneumonia.
Infectious diseases represent the largest segment of the In-Vitro Molecular Diagnostics Market with nearly 50%. It is a big market that is growing fast: $ 5 B with a 14% CAGR. The Point-of-Care Molecular Diagnostics devices market for infectious diseases based on microfluidics has a size of approximately 900 M $ with an even higher growth rate.
PneumoSIP product line is expected to become the main source of growth for the company in the next 5 years. The H2020 SME instrument phase I feasibility study has four main objectives:
- To verify with final users (physicians and lab technicians) the features of the problem.
- To validate and close the first specifications of the product with final users and customers.
- To confirm with updated market studies the future Pn";71429;50000;H2020-SMEINST-1-2014;SME-1;LABORATORIOS ALPHA SAN IGNACIO PHARMA S.L. - ALPHASIP;ES;;; 194699;650731;NDTMF;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;New Drying Techniques for Moulded Fibres;1/10/2014;31/03/2015;;"Problem
Disposable plastic bottles are an increasing threat to our environment. 50 billion water bottles alone are consumed every year and 80 % of all plastic bottles end up in landfills. EcoXpac owns the technology to produce a 100% biodegradable bottle the Green Fibre Bottle.

Solution
The fibre material is not new in itself, but so far it has not been possible for packaging manufacturers to produce a bottle at a competitive prize - primarily due to the extremely energy consuming and complicated drying process and long production cycle. EcoXpac owns the rights to an energy saving impulse-drying technique that will disrupt the market for moulded fibres. The technique will make it possible to replace all kinds of plastic products with biodegradable fibre products.

The project
Proof of concept has so far been achieved in a test facility. The purpose of the current project is to prepare the construction of an impulse drying process facility at a larger and more advanced scale that can serve as a demonstration plant. The innovation in this project has the potential to revolutionize the packaging industry in the same way as Tetra Pak did.

The customer
The end customers will be large manufacturers of Fast Moving Consumer Goods. The business model of EcoXpac is to sell the rights to use the fibre bottle within a specific end-user segment, e.g. dairy products, to global manufacturer and then work closely with the packaging manufacturer to customize the production line to their needs.

The team
The team behind EcoXpac possesses high-expertise in moulded fibre process technology and a proven commercial track record. EcoXpac works in close collaboration with the biggest dairy producer in Scandinavia, Arla Foods, about the development of a fibre bottle for Arla Foods products.";71429;50000;H2020-SMEINST-1-2014;SME-1;ECOXPAC A/S;DK;;; 194562;649186;ISIGrowth;SIGNED;H2020-EU.3.6.;EURO-2-2014;H2020;Innovation-fuelled, Sustainable, Inclusive Growth;1/05/2015;30/04/2018;;"ISIGrowth aims to offer comprehensive diagnostics of the relationships between innovation, employment dynamics and growth in an increasingly globalized and financialised world economy, and, on the grounds of such analysis, elaborate a set of policy scenarios and deliver a coherent policy toolkit able to achieve the Europe 2020 objectives of smart, sustainable and inclusive growth.
ISIGrowth brings together researchers from eight international institutions that have contributed to some of the most cutting edge areas of innovation studies (e.g. systems of innovation; technological trajectories/paradigms; industry dynamics) and areas that connect understanding of economic growth at the macro, meso and micro level. Key individuals leading the work packages have shaped these areas internationally and have expertise in managing successful international projects (including EU ones) at the highest level. The research agenda is ambitious and transformative, while building solidly on the foundations of the EC 2020 strategy (and the Innovation Union in particular), so to create policy recommendations that can both improve the EC2020 strategy as well as connect it to the fundamental need facing policy makers today in the face of one the largest financial and economic crisis in history: the relationship between innovation policy, financial market reform, and macroeconomic stimulus policy.
ISIGrowth will be policy focussed, with policies emerging from a strong interaction between key theoretical insights (e.g. from Schumpeterian economics of innovation and Keynesian demand policies), with key empirical studies (using cutting edge methods in complexity science, non parametric statistics, as well as detailed case studies of business and industry histories). This theoretical and empirical interaction will be embedded in a dynamic process of engagement with stakeholders in our cutting edge and innovative Civil Action Network (CAN) and Business Forum (BF).";3073610;2498610;H2020-EURO-SOCIETY-2014;RIA;SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;IT;"FONDATION NATIONALE DES SCIENCES POLITIQUES;UNIVERSITAET ZUERICH;TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;UNIVERSITY OF SUSSEX;UNIVERZA V LJUBLJANI;UNIVERSITAET BIELEFELD";"FR;CH;US;UK;SI;DE"; 194608;649639;EnPC-INTRANS;SIGNED;H2020-EU.3.3.7.;EE-21-2014;H2020;Capacity Building on Energy Performance Contracting in European Markets in Transition;1/03/2015;28/02/2017;;"A project proposed by Deutsche Gesellschaft fr Internationale Zusammenarbeit (GIZ) GmbH in cooperation with the Climate Protection and Energy Agency of Baden-Wrttemberg/Germany and European competence centres on Energy Performance Contracting (EnPC) in Croatia, Greece and Slovenia, a competence centre for e-learning in Slovakia, and key actors for the promotion of EnPC at the local level in Latvia, Serbia, Romania and Ukraine.
Objective of EnPC-INTRANS is to increase the market uptake of technologies for the improvement of energy efficiency (EE) in public buildings and services by means of fostering private sector participation in innovative financing schemes for EE investments. This will be achieved by means of implementing large-scale capacity building for local public authorities and SMEs to jointly set-up and use adapted EnPC models for EE services (topic 3 in the scope of the EE21 call).
European best practices in EnPC are adapted to local conditions (WP2) and presented to relevant target groups in the partner countries (WP3). Training needs of local public authorities and SMEs are assessed in intensive stakeholder dialogue, providing the basis for design and implementation of efficient training concepts and tools making use of advanced on-line technologies for European-wide capacity development (WP3). Trainers are trained throughout the partners networks (WP4) and the developed training concepts and tools are demonstrated in national and international cooperation seminars (WP5). The achieved impact of large-scale capacity development on the European market for EnPC projects is continuously monitored and evaluated (WP6), and the project results are disseminated to all EU28 member states (WP7).
At least 50 trained trainers and 3,000 trained experts will directly benefit from the project and cater for the initiation and development of EnPC projects in partner countries and beyond, providing for energy savings of more than 60 GWh per year when implemented. (The lead Partner) GIZ has been commissioned by the German Federal Ministry of Economic Cooperation and Development (BMZ) with the implementation of the project Energy Efficiency in Municipalities in the Ukraine. The EC through this Horizon 2020 project thus contributes complementarily to achieving the overall objectives of the BMZ-funded project as the BMZ-funded project supports the implementation of the EU Horizon project. None of the activities covered by this work programme are funded by any other funding.";1922870,85;1922870,1;H2020-EE-2014-3-MarketUptake;CSA;DEUTSCHE GESELLSCHAFT FUR INTERNATIONALE ZUSAMMENARBEIT (GIZ) GMBH;DE;"CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;AGENTIA PENTRU EFICIENTA ENERGETICASI ENERGII REGENERABILE PLOIESTI-PRAHOVA ASOCIATIE;FIATU;STALNA KONFERENCIJA GRADOVA I OPSTINA;ZAVOD ENERGETSKA AGENCIJA ZA SAVINJSKO SALESKO IN KOROSKO;KEA KLIMASCHUTZ- UND ENERGIEAGENTUR BADEN-WUERTTEMBERG GMBH;BIEDRIBA ZEMGALES REGIONALA ENERGETIKAS AGENTURA;ENERGETSKI INSTITUT HRVOJE POZAR;E-CODE";"EL;RO;UA;RS;SI;DE;LV;HR;SK"; 194828;653004;MARGIN;SIGNED;H2020-EU.3.7.;FCT-13-2014;H2020;Tackle Insecurity in Marginalized Areas;1/05/2015;30/04/2017;;The MARGIN project coordination activities are intended to contribute to the creation of sustainable modes of cooperation between stakeholders dealing with security issues. The project provides policy makers with evidence-based tools for developing and assessing strategies targeted at the reduction of insecurity among different demographic and socioeconomic groups. It sets up an international environment for knowledge exchange involving some of the leading EU institutions in Crime Victimization Surveys (CVSs). Along with police statistics, CVSs have become an internationally recognized tool for identifying and analysing factors affecting public and personal perceptions of insecurity. Perception of insecurity arises as a very heterogeneous concept not limited to actual crime rates but encompassing a wide range of other aspects including personal wellbeing, trust in public institutions, justice and social integration. MARGIN addresses the topic of insecurity by taking into account its heterogeneity. Based on previous and on-going research activities, the project's specific aims are: (1) to create a framework enabling end-users to contrast objective and subjective measures of insecurity (i.e. compare police statistics with CVS data), (2) to develop and validate a thematic survey with a sample of 15.400 citizens that allows for the assessment of the impact of demographic, socio-economic and socio-geographic variables on the perception of insecurity (3) to investigate the socio-cultural determinants of insecurity perception through the implementation of anthropological fieldwork in five EU countries (4) to share best practices and outcomes in a final event with 100 key end-users. By deepening the understanding of the root causes of insecurity, MARGIN is expected to foster the creation of community resilience practices empowering citizens (especially among those at risk of exclusion) to better face risks and increase the public and personal perception of security.;1881399,5;1881399,5;H2020-FCT-2014;CSA;UNIVERSITAT DE BARCELONA;ES;"EUROCRIME - RESEARCH, TRAINING AND CONSULTING SRL;ORSZAGOS KRIMINOLOGIAI INTEZET;UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA;UNIVERSITY COLLEGE LONDON;Departament d'Interior - Generalitat de Catalunya;INSTITUT NATIONAL DES HAUTES ETUDES DE LA SECURITE ET DE LA JUSTICE";"IT;HU;UK;ES;FR"; 194605;649727;BUILD UPON;SIGNED;H2020-EU.3.3.7.;EE-09-2014;H2020;A multi-stakeholder Regional Action Network as a living structural base to effectively help define and implement deep energy efficient building renovation at local, national and European level.;1/03/2015;28/02/2017;;"BUILD UPON: Empower stakeholders to assist public authorities.

1. Provide large-scale capacity building or engagement activities: The key objective is to engage and empower a critical mass of over 1,000 stakeholders with the process of defining and implementing their long-term national renovation strategy (Article 4, Energy Efficiency Directive). Process carried out by an important organisational innovation, Green Building Councils (GBCs), in BG,CZ,ES, HR, IT, IE, FI, LV, RO, SE, SI, SK and TR. GBCs are multi-stakeholder platforms, formalising a Regional Action Network of connected actors who will ensure the continuation of the activities beyond the projects duration.

2. Target specific actors among a wide spectrum of stakeholders: The renovation stakeholder ecosystem will be mapped across the Project countries, to understand precisely which organisations will be needed to define and implement Article 4 and how this system functions. BUILD UPON has received over 100 letters of support across all its target groups.

3. Demonstrate a strong European added value: The complex landscape of renovation initiatives (both public policy and market driven) will be compressed in a living RenoWiki resource, to enable stakeholder understanding and dialogue, and ensure all stakeholders are on the same page. The stakeholder community will be developed through a series of nearly 80 workshops across the region at local, national and European level. These will explore collaborative and solution focused working methods to deliver the stakeholder buy-in required by government to define and implement ambitious and viable Article 4 strategies. Experts involved with the design and management of identified best practice renovation initiatives will help stakeholders assess feasibility for implementing these in other countries, to move best practice sharing beyond information to action, and an incubator for new concepts will help launch further implementation orientated projects.";2351567,5;2351563;H2020-EE-2014-3-MarketUptake;CSA;GREEN BUILDING COUNCIL-ESPANA CONSEJO PARA LA EDIFICACION SOSTENIBLE-ESPANA;ES;"SLOVENSKO ZDRUZENJE ZA TRAJNOSTNO GRANDJO;GBC SUOMI RY;UKGBC LIMITED;IRISH GREEN BUILDING COUNCIL LIMITED LBG-IGBC;CEVRE DOSTU YESIL BINALAR DERNEGI IKTISADI ISLETMESI;LATVIJAS ILGTSPEJIGAS BUVNIECIBAS PADOME;HRVATSKI SAVJET ZA ZELENU GRADNJU;GREEN BUILDING COUNCIL ITALIA;CESKA RADA PRO SETRNE BUDOVY;BULGARIAN GREEN BUILDING COUNCIL;BUILDING GREEN IN SWEDEN AB;SLOVENSKA RADA PRE ZELENE BUDOVY;ASOCIATIA ROMANIA GREEN BUILDING COUNCIL";"SI;FI;UK;IE;TR;LV;HR;IT;CZ;BG;SE;SK;RO"; 194421;646172;AURES;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-04-2014;H2020;Auctions for Renewable Energy Support: Effective use and efficient implementation options;1/01/2015;31/12/2017;;Auctions, as a competitive and market-based mechanism, are on the verge of becoming a prevailing feature in support policies for renewable energy in Europe. A comprehensive assessment of auctions and their suitability for renewable support in Europe is urgently needed to facilitate their successful design and cost-efficient implementation. Auctions have the potential to significantly improve the performance of renewable electricity support in Europe, but there are potential pitfalls and difficulties to be avoided. AURES combines dedicated, detailed and target-oriented analysis of auctions and their interactions with other energy policy mechanisms and markets with capacity building of policy makers and market participants. The project will identify and evaluate suitable auction design options and their effects under different market conditions using tailored theoretical, empirical, experimental, and model-based approaches, and so develop best practices and policy recommendations for future auction design. Building on worldwide experiences with auctions in energy policy and other industries and on close cooperation with ongoing auction implementation cases in Europe, a strong knowledge base will be developed, enabling policy makers and market participants to make informed decisions. This knowledge base will be processed in a flexible policy support tool that provides policy makers with tailor-made information suited to their specific situation and policy preferences. By facilitating an intense and continuous stakeholder dialogue and by establishing a knowledge sharing network via workshops, webinars, bilateral meetings, and expert consultations, the project will serve as capacity building platform. The project consortium consists of eight renowned public institutions and private firms representing seven European countries and includes some of the leading energy policy experts in Europe, with an impressive track record of successful research and coordination projects.;1552600,75;1552600,75;H2020-LCE-2014-3;CSA;DANMARKS TEKNISKE UNIVERSITET;DK;"ECOFYS GERMANY GMBH;TECHNISCHE UNIVERSITAET WIEN;THE UNIVERSITY OF EXETER;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;TAKON GmbH - SPIELTHEORETISCHE BERATUNG;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;CONCITO";"DE;AT;UK;ES;DK"; 194853;653354;CERAM;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;First ceramics of Atlantic Europe: manufacture and function;1/10/2015;30/09/2017;;"The arrival of farming had important consequences on many aspects of human society, from health to ideology. The study of this process therefore constitutes a key theme in prehistory and archaeology. One of the traits traditionally associated with the transition to farming in Europe is the introduction of pottery technology. For centuries, archaeologists have documented the appearance and dispersal of ceramic vessels across the European continent, using them as proxy for the shift to farming, domestication and sedentism, collectively known as the Neolithic transition. However, the role of pottery in the transition to farming is unclear. In other parts of world there are examples of both pre-farming pottery production and aceramic farming communities. With new research the basis that has underpinned centuries of Neolithic research is beginning to be questioned. Crucially, only by understanding the use and function of pottery can this technology be meaningfully linked to farming. By applying the latest chemical and molecular analysis, CERAM aims to reconstruct the use of pottery during this key transition focusing on the sequence of Atlantic Southern Europe.
The host will train a ceramic specialist from Spain, with no prior experience of organic residue analysis, in the latest molecular and isotopic techniques providing the necessary skills for her to establish a similar facility in her home country where none currently exist. In turn, the fellow will bring specific expertise of ceramic technological analysis, not currently available at the host institution. Through her extensive prior experience and contacts, she will also provide an opportunity for the host to expand the application of organic residue analysis to a novel and under-researched context, i.e. Atlantic Southern Europe and consolidate long-term collaborations with a leading institute of coastal prehistory.";183454,8;183454,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;University of York;UK;;; 194521;648143;SpoKiGen;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Spore killer genomics: elucidating causes and consequences of a fungal meiotic drive element;1/05/2015;30/04/2020;;The traditional view of the genome is that of a highly coordinated network that has evolved to produce a successful individual. However, the alternative view of the genome as containing intrinsically conflicting parts that coevolve antagonistically, has recently emerged. Today, it is widely accepted that conflicts caused by selfish genetic elements is a driving force for evolutionary innovation, and hence, is of fundamental importance for all aspects of evolution. Nevertheless, empirical data on the topic is largely lacking. Here, I introduce the fungus Neurospora as a novel study system of the evolutionary significance of meiotic drive. In this sexual eukaryote model system, the meiotic drive element Spore killer is found. The cytological properties and natural distribution of Spore killing in Neurospora has been investigated for several decades, and preliminary data suggests that it is an important driver of both genome evolution and of higher-order evolutionary processes. The existing knowledge and resources of this system provide a foundation for the proposed research program, in which I plan to build a tool-kit of genomic and experimental resources to I) identify and characterize the gene(s) encoding Spore killer elements, II) assess the strength of Spore killer as a meiotic drive, III) unravel the evolutionary history of the Spore killer complex in Neurospora, IV) investigate the association between Spore killer and genome evolution, and V) analyze the role of Spore killer as a driver of speciation and mating system transitions. This research program will manifest the Spore killer as a primary and pioneering model for the study of meiotic drive, and profoundly impact our understanding of segregation distorters as drivers of eukaryote genome evolution. Furthermore, insights emerging from the project presented are conceptually important for basic evolutionary biology, in the study of natural selection acting at multitudinal levels in a biological hierarchy.;2000000;2000000;ERC-2014-CoG;ERC-COG;Uppsala universitet;SE;;; 194531;648283;GROWMOF;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Modelling of MOF self-assembly, crystal growth and thin film formation;1/08/2015;31/07/2020;;"Metal-organic frameworks (MOFs) constitute one of the most exciting developments in recent nanoporous material science. Synthesised in a self-assembly process from metal corners and organic linkers, a near infinite number of materials can be created by combining different building blocks allowing to fine tune host guest interactions. MOFs are therefore considered promising materials for many applications such as gas separation, drug delivery or sensors for which MOFs in form of nanoparticles, composite materials or thin films are required. For MOFs to realise their potential and to become more than just promising materials, a degree of predictability in the synthesis and the properties of the resulting material is paramount and the full multiscale pathway from molecular assembly to crystal growth and thin film formation needs to be better understood.

Molecular simulation has greatly contributed to developing adsorption applications of MOFs and now works hand-in-hand with experimental methods to characterise MOFs, predict their performance and study molecular level phenomena. In contrast, hardly any simulation studies exist about the formation of MOFs, their crystal growth or the formation of thin films. Yet such studies are essential for understanding the fundamentals which will ultimately lead to a better control of the material properties. Building on my expertise in molecular modelling including the development of methods to model the synthesis of porous solids, we will develop new methods to study:

1. the self-assembly process of MOFs under synthesis conditions
2. the formation of nanoparticles
3. the integration of MOF nanoparticles into composite materials and the self-assembly into extended structures
4. the layer-by-layer growth of thin films

At the end of the project we will have transformed our understanding of how MOFs form at a variety of length scales and opened up new research directions for the targeted synthesis of MOFs fit for applications.";1738715;1738715;ERC-2014-CoG;ERC-COG;UNIVERSITY OF BATH;UK;;; 194687;650785;SWaM;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Smart Water Manager SCADA system for entire grid of water wells management.;1/11/2014;28/02/2015;;"The problem: water reservoir and water wells are fragmentarily managed. This causes high energy inefficiency of water pumping and provision operations and depletion of aquifers.

The solution: the Smart Water Manager - SWAM is a system composed by a set of sensors and actuators interfaced through a remote data logger to a data mining, analytics and actuation expert system.

Value Proposition: the SWAM is able to control and optimise the water pumping and the aquifer exploitation, increasing the overall energy efficiency and reducing maintenance cost of entire grids of water wells.

Business Model: Main revenue streams are the royalties on the energy savings achieved by water managers trough the SWAM system (ESCO model).

Users/Clients: Water Management Companies and Public Autorithies

Market: 20M revenues at the 3rd year after commercialization.

Competition: Specific competitors dealing with SCADA/DCS automation systems for water plants and aqueduct monitoring and innovative solution for optimising the performance of drinking water networks

Revenue Streams: royalties on the energy savings achieved by water managers trough the SWAM (ESCO model).

Team: Edillio Srl, Hydroingea Srl

Required funding: 1,5M";71429;50000;H2020-SMEINST-1-2014;SME-1;HYDROINGEA SRL;IT;EDILLIO SRL;IT; 194685;651039;ECOBREW;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.2.";SFS-08-2014-1;H2020;New eco-efficient and healthy professional espresso coffee machine;1/11/2014;30/04/2015;;"Coffee is the first food commodity in the world, and a big part of it is consumed in form of expresso in bars, restaurants or coffee shops. However, current professional espresso coffee machines are based on technologies that have barely evolved in 100 years. These machines are extremely energy inefficient whilst also, due to the materials used internally in the machine, generate unhealthy metal impurities which are then passed to the customer in the drink.

This creates a market anomaly, since the niche of coffee shop customers who are looking for environmentally and socially responsible coffee is one of the only fast growing segments in the mature coffee market.
For thirty years the SME Company IBERITAL has been designing, manufacturing and selling professional espresso coffee machines to coffee shops across the World. IBERITAL has noticed the market anomaly and has therefore developed a prototype coffee shop espresso machine that reduces energy consumption by 30% and does not allow migration of metals from the machine to the final consumer.

IBERITALs prototype generates the following benefits: reduction of energy consumption of professional espresso coffee makers by 30%; reduction of overall energy consumption in the professional coffee sector by 3% within 5 years; production of heavy metal impurity-free espresso coffee; opening a competitive new business line for IBERITAL.

The overall aim of ECOBREW is to confirm the potential of the prototype, to perform the necessary production line adaptations and industrial up scaling, and finally to demonstrate and prepare for commercialisation of the ECOBREW professional espresso coffee machine.";71429;50000;H2020-SMEINST-1-2014;SME-1;IBERITAL DE RECAMBIOS SA;ES;;; 194547;648711;GAINBYSTRAIN;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Gain by Strain: Precise Cuts of Cyclopropanes as Key to Molecular Complexity;1/07/2015;30/06/2020;;"A central discipline of chemistry is the design und creation of molecules with defined structural and chemical properties. Stretching synthetic horizons is a never-ending endeavor to inspirit the chemist s creativity in preparing compounds and materials yet to be discovered. Relying on their high strain energy cyclopropanes, as carriers of the most fundamental ring geometry, offer a unique reactivity which allows for a multitude of transformations being grouped in ring-opening reactions, cycloadditions and rearrangements. Major advantage of all these processes is the cyclopropane-derived intrinsic atom-economy.
In this research project, we propose a number of uncommon and challenging reactions making use of donor-acceptor cyclopropanes. Introducing a distinctively controlled bond cleavage we seek to develop novel modes of 1,3-bifunctionalization by ?-bond metathesis, by using hypervalent iodine reagents and by merging organocatalysis with photoredox catalysis. Unprecedented ring-enlargements to four-membered rings by [3\1]-cycloadditions employing isonitriles, carbenes and nitrenes are envisioned, aryne insertions into the three-membered ring leading to indane systems are planned and a general concept for [3\3]-cycloadditions with 1,3-dipoles is presented paving the way to unusual syntheses of heterocycles.
A distinct class of compounds obtainable by our methodology will set the stage to access completely unexplored heterocyclic -systems being of interest for material science and molecular electronics.
Besides our central goals of advancing organic methodology and to demonstrating the synthetic utility of these novel reactions, we anticipate that mechanistic insights gained by experimental and computational means will be of high impact for the chemistry of this fundamental structural unit in general.";1994250;1994250;ERC-2014-CoG;ERC-COG;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;DE;;; 194485;647077;NewSpindleForce;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;A new class of microtubules in the spindle exerting forces on kinetochores;1/04/2015;31/03/2020;;At the onset of division the cell forms a spindle, a micro-machine made of microtubules, which divide the chromosomes by pulling on kinetochores, protein complexes on the chromosome. The central question in the field is how accurate chromosome segregation results from the interactions between kinetochores, microtubules and the associated proteins. According to the current paradigm, the forces on kinetochores are produced by k-fibers, bundles of microtubules extending between the spindle pole and the kinetochore. The proposed project is built upon a groundbreaking hypothesis that a new class of microtubules, which we term bridging microtubules, bridge sister kinetochores. Our preliminary results show that bridging microtubules are responsible for the positioning of kinetochores in HeLa and PtK1 cells. Bridging microtubules have not been studied before because this requires cutting-edge microscopy and laser microsurgery techniques. By applying these methods, with which I have extensive expertise, we will determine the organization of these microtubules, identify the proteins that link them with k-fibers, and uncover where and how the forces for kinetochore positioning and movement are generated. My strength is in taking an interdisciplinary approach, which I will use in this project by combining laser microsurgery with genetic perturbations, quantitative measurements of the responses and comparison with theoretical models. Understanding the role of bridging microtubules in force generation and chromosome movements will not only shed light on the mechanism of chromosome segregation, but may also increase the potential of mitotic anticancer strategies, as the spindle is a major target for chemotherapy. The proposed ERC funding is essential for the success of these timely and ambitious experiments, allowing me to strengthen my position as an international leader in research on cell division, thereby increasing Europe's foremost position in this field.;2150000;2150000;ERC-2014-CoG;ERC-COG;RUDER BOSKOVIC INSTITUTE;HR;;; 194464;646649;SymplecticEinstein;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;The symplectic geometry of anti-self-dual Einstein metrics;1/09/2015;31/08/2020;;"This project is founded on a new formulation of Einstein's equations in dimension 4, which I developed together with my co-authors. This new approach reveals a surprising link between four-dimensional Einstein manifolds and six-dimensional symplectic geometry. My project will exploit this interplay in both directions: using Riemannian geometry to prove results about symplectic manifolds and using symplectic geometry to prove results about Reimannian manifolds.

Our new idea is to rewrite Einstein's equations using the language of gauge theory. The fundamental objects are no longer Riemannian metrics, but instead certain connections over a 4-manifold M. A connection A defines a metric g_A via its curvature, analogous to the relationship between the electromagnetic potential and field in Maxwell's theory. The total volume of (M,g_A) is an action S(A) for the theory, whose critical points give Einstein metrics. At the same time, the connection A also determines a symplectic structure \omega_A on an associated 6-manifold Z which fibres over M.

My project has two main goals. The first is to classify the symplectic manifolds which arise this way. Classification of general symplectic 6-manifolds is beyond current techniques of symplectic geometry, making my aims here very ambitious. My second goal is to provide an existence theory both for anti-self-dual Poincar--Einstein metrics and for minimal surfaces in such manifolds. Again, my aims here go decisively beyond the state of the art. In all of these situations, a fundamental problem is the formation of singularities in degenerating families. What makes new progress possible is the fresh input coming from the symplectic manifold Z. I will combine this with techniques from Riemannian geometry and gauge theory to control the singularities which can occur.";1162880;1162880;ERC-2014-CoG;ERC-COG;UNIVERSITE LIBRE DE BRUXELLES;BE;;; 194548;648763;INTERACT;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Intelligent Non-woven Textiles and Elastomeric Responsive materials by Advancing liquid Crystal Technology;1/04/2015;31/03/2020;;"A grand challenge in todays materials research is the realization of flexible materials that are also intelligent and functional. They will be the enablers of true breakthroughs in the hot trends of soft robotics and wearable technology. The standard approach to the latter is to decorate rubber sheets with electronic components, yielding two serious flaws: rubber is uncomfortable as it does not breath and solid state electronics will eventually fail as a garment is flexed and stretched when worn. While the softness of rubber is ideal it must be used in the form of textile fibers to provide breathability, and for long-term failure resistance we need intelligent components that are soft. A solution to this conundrum was recently presented by the PI with the concept of liquid crystal (LC) electrospinning. The extreme responsiveness of LCs is transferred to a non-woven textile by incorporating the LC in the fiber core, yielding a smart flexible mat with sensory function. Moreover, it consumes no power, providing a further advantage over electronics-based approaches. In a second research line he uses microfluidics to make LC rubber microshells, functioning as autonomous actuators which may serve as innovative components for soft robotics, and photonic crystal shells. This interdisciplinary project presents an ambitious agenda to advance these new concepts to the realization of soft, stretchable intelligent materials of revolutionary character. Five specific objectives are in focus: 1) develop understanding of the dynamic response of LCs in these unconventional configurations; 2) establish interaction dynamics during polymerisation of an LC precursor; 3) elucidate LC response to gas exposure; 4) establish correlation between actuation response and internal order of curved LCE rubbers; and 5) assess usefulness of LC-functionalized fibers and polymerized LC shells, tubes and Janus particles in wearable sensors, soft robotic actuators and high-security identification tags.";1929976;1929976;ERC-2014-CoG;ERC-COG;UNIVERSITE DU LUXEMBOURG;LU;;; 194813;652757;ARCGATE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;ARCGATE: maximizing the potential of Arctic Ocean Gateway array;1/07/2015;30/06/2017;;Predictions that the Arctic Ocean might be ice-free by the middle of the 21st century are of major social, economic, political and scientific interest. Making sensible decisions on European Arctic economic development requires that scientific knowledge and data are more accessible and usable by both academics and non-academics alike. ARCGATE aims to obtain innovative physical and biogeochemical budgets for the Arctic Ocean based on the Arctic gateway observations. Integrating Arctic gateway observations the applicant has recently developed an innovative method to obtain quasi-synoptic and time varying comprehensive budget estimates using a box inverse model. The main objective of ARCGATE is to extend the inverse box model methodology to calculate multi-year Arctic heat and fresh water (FW) budget variations during 2004-2010, including import of heat, export of FW and storage of both. Over 20 million euro has already been spent on Arctic observations during this period. The host institute of this proposal holds about half of historical Arctic gateway observations. The obtained budget estimates will be disseminated and exploited through an open data policy. Furthermore, ARCGATE aims to push disciplinary and sectional boundaries. By applying the same pan-Arctic approach, the total alkalinity budget for summer 2005 will be calculated. A sound estimate of the total alkalinity budget will significantly advance understanding of the entire carbonate system of the Arctic Ocean. Mobility from UK to Germany is key to the success of ARCGATE enabling synthesis of the pan-Arctic inverse box-model developed in UK over the last six years with state-of-the-art estimates of Arctic Ocean heat, FW storage changes in time, and a new interpretation of total alkalinity all developed at the host institute for this project. Close links to the commercial Arctic shipping sector will be developed by disseminating the results of ARCGATE at international shipping conferences.;171460,8;171460,8;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ALFRED-WEGENER-INSTITUT HELMHOLTZ- ZENTRUM FUER POLAR- UND MEERESFORSCHUNG;DE;;; 194495;647311;Sol-Pro;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Solution Processed Next Generation Photovoltaics;1/07/2015;30/06/2020;;The profound advantages of printed photovoltaics (PVs), such as their light weight, mechanical flexibility in addition to the small energy demand, and low cost equipment requirements for roll-to-roll mass production, characterise them as a dominant candidate source for future electrical power. Over the last few years, the discovery of novel solution processed electronic materials and device structures boosted PV power conversion efficiency values. Despite that, power conversion efficiency is not a 'stand-alone' product development target for next generation PVs. Lifetime, cost, flexibility and non-toxicity have to be equally considered, regarding the technological progress of solution processed PVs. The ambit of the Sol-Pro research programme is to re-design solution processed PV components relevant to the above product development targets. Based on this, processing specifications as a function of the electronic material properties will be established and provide valuable input for flexible PV applications. Adjusting the material characteristics and device design is crucial to achieve the proposed high performance PV targets. As a consequence, a number of high-level objectives concerning processing/materials/electrodes/interfaces, relevant to product development targets of next generation solution processed PVs, are aimed for within the proposed ERC programme.;1840940;1840940;ERC-2014-CoG;ERC-COG;TECHNOLOGIKO PANEPISTIMIO KYPROU;CY;;; 194507;647548;Protein Lego;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Protein design from sub-domain sized fragments;1/09/2015;31/08/2020;;"Proteins are ubiquitous, very diverse, and participate in virtually every cellular process. Nature has generated this impressive set of proteins using mechanisms such as recombination of smaller, sub-domain sized protein fragments that serve as building blocks in a Lego-like manner. Based on these observations we propose a rational design strategy in which new functional proteins are build from fragments of existing proteins. With this approach we aim to tackle a long-standing goal in biochemistry, namely the design of complex, custom-made proteins.
Initial experiments that recombine fragments from the same as well as from different folds have been successful in creating new proteins. Moreover, the utilized fragments contribute their unique functional properties to the protein chimeras, which is a tremendous advantage of using existing subunits for the design. Here, we aim to generalize this approach. We will identify common structural fragments and classify them based on their associated functions. We will build stable hybrid proteins from different folds, transfer functional sites associated with particular fragments, and thereby learn about general design rules.
The proposed approach offers a rigorous test for the identification of minimal determinants of protein structure and function. It simultaneously allows us to test our understanding of protein evolution and will have profound implications on the current view of structural classification and interactions. And lastly, the development of a reliable methodology for the design of complex proteins will be very valuable for synthetic biology and bioengineering approaches.";1950000;1950000;ERC-2014-CoG;ERC-COG;UNIVERSITAET BAYREUTH;DE;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE; 194589;649493;STEP;SIGNED;H2020-EU.3.6.;YOUNG-5b-2014;H2020;Societal and political engagement of young people in environmental issues;1/06/2015;30/11/2017;http://step4youth.eu/;"The overall objective of the project is to develop and pilot test a cloud eParticipation SaaS platform, (available as a mobile application and through a web platform) enhanced with web / social media mining, gamification, machine translation, and visualisation features, which will promote the societal and political participation of young people in the decision-making process on environmental issues.
The project will employ innovative social media analytics and monitoring tools, as part of effective strategies that will be developed, in order to engage young citizens in the pilot activities and increase their motivation to participate.
Four pilots in an operational environment have been selected for the deployment of STEP solution in 4 locations: Italy, Spain, Greece, and Turkey, with the participation of one regional authority, 3 municipalities, and an association of municipalities. The pilots are expected to involve testing by 8.200 young users and 85 policy makers. 65 decision-making procedures with an impact on the environment are expected to be tested.
The project will assess the usability, effectiveness and impact of the STEP service project in embedding open engagement in public sector processes, and will identify the key barriers for wide scale deployment.
Dissemination activities specifically designed for the needs of young people and policy makers will be employed.
A business strategy will be developed for the wide take-up of the integrated STEP platform and its reusable components, individually, or in combinations. The potential for scalability and adaptation to other regions will be assessed, and organisations that can be involved in the wide deployment of the platform and its components will be approached.";3157941,07;2559187,5;H2020-YOUNG-SOCIETY-2014;IA;DRAXIS ENVIRONMENTAL S.A.;EL;"THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERTAY DUNDEE;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;PLANO2 SYMVOULEFTIKES YPIRESIES IKE;KAIROS FUTURE AKTIEBOLAG;KRITI;AYUNTAMIENTO DE VALDEMORO;YOUTH AND ENVIRONMENT EUROPE;INMARK EUROPA SA;HATAY METROPOLITAN MUNICIPALITY;COMUNE DI SANT'AGATA DEL BIANCO;Sampas Bilisim Ve Iletisim Sistemleri Sanayi Ve Ticaret A.S.;LINGUATEC GMBH;INMARK ESTUDIOS Y ESTRATEGIAS SA;AJUNTAMENT DE MOLLET DEL VALLES";"UK;EL;SE;ES;CZ;TR;IT;DE"; 194406;645984;ERN;SIGNED;H2020-EU.2.1.3.7.;NMP-34-2014;H2020;The European Remanufacturing Network - coordinating and supporting European remanufacturers;1/02/2015;31/01/2017;;"Remanufacturing is an important component of a resource efficient manufacturing industry. By keeping components and their embodied material in use for longer, significant energy use and emissions to air and water can be avoided. In addition to environmental benefits, remanufacturing provides opportunities for the creation of highly skilled jobs and economic growth.

Despite these accolades, remanufacturing is an undervalued part of the industrial landscape and an under-recognised sustainable industry. Activity to promote remanufacturing is currently undertaken at a sectoral level for some product sectors. In Europe, unlike in the recycling industry, cross-sectoral activities to facilitate knowledge transfer and promote the industry do not exist. Our major competitors, the US and China, already have a common vision and strategy for remanufacturing within their industrial landscape. An outcome may be that European remanufacturing could lose competitiveness against these more organised sectors. As a result, there is a real need for a European-level solution to encourage remanufacturing throughout Europe.

This proposal sets out the formation, coordination and support of a European Remanufacturing Network (ERN) over a project period of two years, which aims to:
encourage new businesses to take up remanufacturing
help existing remanufacturers improve their operations
improve competitiveness of remanufacturers domestically and internationally
create greater awareness of remanufacturing in the public and policy makers to increase demand and address barriers.

The aims of the ERN will be achieved through:
mapping out the current remanufacturing landscape in Europe and estimating its future potential
disseminating best practice in remanufacturing business models, processes and design
providing industry with remanufacturing knowledge, tools and partnerships
undertaking an information campaign to raise the profile of the European remanufacturing industry.";1489221,25;1489221,25;H2020-NMP-CSA-2014;CSA;OAKDENE HOLLINS LIMITED;UK;"LINKOPINGS UNIVERSITET;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;TECHNISCHE UNIVERSITEIT DELFT;COOPERATIEVE CIRCLE ECONOMY UA;INSTITUT POLYTECHNIQUE DE GRENOBLE;TEKNOLOGIAN TUTKIMUSKESKUS VTT;Teknologian tutkimuskeskus VTT Oy;UNIVERSITY OF STRATHCLYDE";"SE;DE;NL;FR;FI;UK"; 194517;647812;UQMSI;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Uncertainty Quantification and Modern Statistical Inference;1/09/2015;31/08/2020;;"Some of the most important and exciting challenges of our information age have led to the development of novel statistical methodology and algorithms that are designed to deal with inference settings involving high-dimensionality, graphical and network structures, inverse problems, big data, stochastic differential equations, diffusion processes, cosmic microwave background maps, brain tomography etc.
While an abundance of algorithms is now available, a scientifically rigorous theory of uncertainty quantification and statistical decision making for such procedures has not been developed yet. Traditional approaches such as maximum likelihood estimation or parametric Bayesian inference cannot be used naively in increasingly complex contemporary statistical models. The construction of confidence statements and critical values for significant hypothesis tests is, however, of crucial importance for all applications of the statistical sciences to the modern world.
In this research we propose an objective, mathematically rigorous, and practical paradigm for uncertainty quantification in modern statistical inference problems, and illustrate how this approach can be used in some of the recently emerged areas of statistics. Our theory can validate both Bayesian and frequentist approaches to statistical inference, and can be expected to be optimal in an information-theoretic sense. It has potential impact on all areas of scientific theory building, on legal and medical practice, public management of the internet, modern media and other information structures, and also on the foundations of the mathematical discipline of statistics in itself.";1733767;1733767;ERC-2014-CoG;ERC-COG;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194595;649619;IN-BEE;SIGNED;H2020-EU.3.3.6.;EE-12-2014;H2020;Assessing the intangibles: the socioeconomic benefits of improving energy efficiency;1/03/2015;31/03/2017;;"Improving energy efficiency can deliver a range of benefits to the economy and society. However, energy efficiency programmes are often evaluated only on the basis of the energy savings they deliver, without considering the many other socio-economic and environmental intangible benefits delivered. As a result, the full value of energy efficiency improvements in both national and global economies may be significantly underestimated.

The main aim of IN-BEE is to address the theme of energy efficiency and to describe and provide evidence for the many intangible benefits of improving energy efficiency through a multi-disciplinary approach, combining methods, datasets, and techniques from cutting edge research in law and economics, humanities and consumer behavior, regulation and environmental sciences, as well as engineering.

The overall outcome of IN-BEE is to consolidate a set of policy recommendations for the EU and public/private institutions in charge of promoting energy efficiency, competitiveness and environmental and social sustainability.


IN-BEE will impact on both consumers (residential and companies) and policy makers, by:

Developing a set of indicators to measure intangible benefits of energy efficiency
Developing Key Performance Indicators to assess the impact of energy efficiency strategies
Studying relevant cases and identifying best practices
Bridging policy makers and researchers through a web platform
Involving a vast audience of stakeholders

IN-BEE combines a strong scientific base with a concrete and focused approach (based on real-life case studies), aiming to involve primarily regional and local stakeholders and to support them in assessing results of previous plans and initiatives on energy efficiency and, above all, in designing new effective strategies.";1020687,5;1020687,5;H2020-EE-2014-2-RIA;RIA;UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO;IT;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UNIVERSITAET GRAZ;SOFIA ENERGY CENTRE LTD;INSTYTUT ENERGETYKI;DELOITTE ADVISORY SL;TEKNOLOGIAN TUTKIMUSKESKUS VTT;Teknologian tutkimuskeskus VTT Oy";"UK;AT;BG;PL;ES;FI"; 194838;653227;EU-CIVCAP;SIGNED;H2020-EU.3.7.;BES-12-2014;H2020;Preventing and responding to conflict: developing EU CIVilian CAPabilities for a sustainable peace;1/12/2015;30/11/2018;;"The goals of preventing the outbreak of conflict and promoting sustainable peace remain a fundamental challenge to policymakers and analysts alike. The European Union (EU) and its member states require an adequate set of capabilities if they are to address this challenge in a timely and effective manner. EU-CIVCAP will provide a comprehensive, comparative and multidisciplinary analysis of EU civilian capabilities for external conflict prevention and peacebuilding in order to identify the best civilian means to enhance these capabilities and address existing shortfalls. More specifically, this project has identified three inter-related objectives: (1) To assess EU civilian capabilities for external conflict prevention and peace building; (2) To identify and document lessons learned and best practices in EU conflict prevention and peacebuilding; (3) To enhance future policy practice and research on EU conflict prevention and peacebuilding. The project will gather, synthesise, further develop and disseminate knowledge and learning on civilian conflict prevention and peacebuilding. This will be done through, inter alia, the development of a catalogue of lessons learned and best practices reports, the creation of an expert network, engagement through social media, and the organisation of dissemination events in different formats in this area.";1714975;1714974,5;H2020-BES-2014;CSA;UNIVERSITY OF BRISTOL;UK;"THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN;CENTRE FOR EUROPEAN POLICY STUDIES;UNIVERSITEIT MAASTRICHT;ROSKILDE UNIVERSITET;EUROPEAN UNION SATELLITE CENTRE;ISTITUTO AFFARI INTERNAZIONALI;TRANSPARENCY SOLUTIONS LIMITED;FORSVARET OG FORSVARSMINISTERIETS STYRELSER;EUROPEAN PEACEBUILDING LIAISON OFFICE;BEOGRADSKI CENTAR ZA BEZBEDNOSNU POLITIKU UDRUZENJE";"UK;BE;NL;DK;ES;IT;RS"; 194532;648295;GraM3;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Surface-grafted metallofullerene molecular magnets with controllable alignment of magnetic moments;1/06/2015;31/05/2020;;"The molecules retaining their magnetization in the absence of magnetic field are known as single molecule magnets (SMMs). Important problems to be solved on the way to the applications of SMMs in molecular spintronics is their deposition on surfaces and addressing their spins on the single molecular level. In this project we will address these problems by designing SMMs based on endohedral metallofullerenes (EMFs) derivatized with anchoring groups. SMM behaviour recently discovered for DySc2N@C80 and Dy2ScN@C80 in PIs group is governed by a strong magnetic anisotropy (magnetic moments of Dy ions are aligned along the DyN bonds) and ferromagnetic exchange interactions between Dy ions within the clusters. Protected by the carbon cages, these SMMs exhibit uniquely long zero-field relaxation times of several hours at 2 K and provide an ideal system for addressing the individual spin states. Spatial orientation of magnetic moments in EMF-SMMs is determined by the endohedral cluster and is therefore influenced by the orientation of the EMFs molecules and their internal dynamics. We will apply three strategies to control the spatial arrangement of the magnetic moments in EMF-SMMs: (i) deposition of EMF molecules via sublimation; (ii) exohedral modification of EMFs with anchoring groups for grafting of EMFs on surfaces; (iii) introducing photoswitchable units into the anchoring groups which can reversibly change their geometry upon impact of light and will allow switching direction of the magnetic moment in a fully controllable way. Magnetic behaviour of the surface-grafted SMMs will be studied by bulk- and surface-sensitive techniques including X-ray magnetic circular dichroism and especially spin-polarized scanning tunneling microscopy. Successful fulfillment of the objectives of this interdisciplinary high-risk/high-gain project will revolutionize the field of the surface molecular magnetism by allowing the study and control of the SMMs on a single spin level.";1912181;1912181;ERC-2014-CoG;ERC-COG;LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V.;DE;;; 194670;650561;TWIMP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Innovative Laser Solution for Cutting Welding TWIP steel with Improved Performance;1/10/2014;28/02/2015;;"Located in Scurzolengo, city with a high concentration of technology, robotics and automation companies,our Company, ELETTROSYSTEM SAS, is an expert for designing and building high technology solutions through assembly and testing process machines. Currently, ELETTROSYSTEM is one of the leaders in automation technology, with 17 products sold last year regarding special assembly machines, testing benches and complete process automatic lines production, where we obtained 7.4 million turnover in the past year and we offer customized and dedicated solutions to our clients in most of the industrial fields, especially in automotive, aeronautical, energy and biomedical sectors. In addition, ELETTROSYSTEM has experienced an overall growth of 100 % in the last five years (from 3.7 million to 7.4 million turnover) thanks to the special relevance that our international expansion has starred, having presence in Germany, France, rest of Europe and North Africa, South America and Asia.
TWIMP, is the stand-alone equipment for a complete cutting and welding process for TWIP steel. Our product does not only meet the finishing requirements but also will solve the other two current problems:
-Cut and weld complex shapes (required for vehicles structural parts) by using a fiber laser head combined with a robotic arm and a CNC controller, which allows the possibility of moving the source to a precise position.
-Reduce the total cost of the whole process by avoiding the use of filler material and making a final small and compact process machine (so power consumption will be reduced and no foundations would be required).";71429;50000;H2020-SMEINST-1-2014;SME-1;ELETTROSYSTEM di TONA PAOLINO, TONA GIUSEPPE E C. S.A.S.;IT;;; 194672;650572;GEOAPPS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;APPS for geotechnical field work;1/10/2014;31/03/2015;;"The construction market (including civil engineering, environment, energy and mining activities), is a very important market at international level, mainly in the emerging countries. In most of the construction activities, important geotechnical problems must be solved, like slope stability, laying foundation, etc. For solving them, it is necessary to perform a big number of in situ measures and tests, call field work. For example, in the construction of a bridge, SPT test will be needed each 2-5 m for designing the foundations. This work field requires taking measures in situ and then processes them, at the office, for then elaborating the reports to the client. This process is manual, and therefore is high time and cost consuming. Nevertheless, the apps technology and the new smartphones functionalities present a new opportunity to automatize the process: taking the measures with the smart phone, processing them in the smart phone and elaborating the corresponding reports in the smart phone for being sent to the client by e-mail, cloud uploading, server connection, etc.

TERRASOLUM, as international geotechnical engineering, with expertise in apps development, detected this business opportunity with high market impact possibilities, and decided to develop a family of 30 apps for field and laboratory tests and checking and designing calculations in the field works (on-the-fly). Thanks to this apps, the end users (geologists, geotechnical engineers, builder engineers, architects, civil construction technicians) will reduce the time for taking measures from 1-2 days to 1 hours and the cost from 720 to 75, obtaining a very relevant improvement in their productivity.

GEOAPPS will be a strategic project for TERRASOLUM. This project will allow to increase its staff in 6 persons and invoice more than 9,000,000 euros in three years.";71429;50000;H2020-SMEINST-1-2014;SME-1;TERRASOLUM S.L.;ES;;; 194480;646990;NICHOID;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Mechanobiology of nuclear import of transcription factors modeled within a bioengineered stem cell niche.;1/05/2015;30/04/2020;;"Many therapeutic applications of stem cells require accurate control of their differentiation. To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as synthetic niches for the cells, mimicking the native ones. The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of the nuclear pore complexes. If verified, this idea could lead to a breakthrough in biomimetic approaches to engineering stem cell differentiation.
I investigate this question specifically in mesenchymal stem cells (MSC), because they are adherent and highly mechano-sensitive to architectural cues of the microenvironment. To verify my hypothesis I will use a combined experimental-computational model of mechanotransduction. I will a) scale-up an existing three-dimensional synthetic niche culture substrate, fabricated by two-photon laser polymerization, b) characterize the effect of tridimensionality on the differentiation fate of MSC cultured in the niches, c) develop a multiphysics/multiscale computational model of nuclear import of transcription factors within differentially-spread cultured cells, and d) integrate the numerical predictions with experimentally-measured import of fluorescently-labelled transcription factors.
This project requires the synergic combination of several advanced bioengineering technologies, including micro/nano fabrication and biomimetics. The use of two-photon laser polymerization for controlling the geometry of the synthetic cell niches is very innovative and will highly impact the fields of bioengineering and biomaterial technology. A successful outcome will lead to a deeper understanding of bioengineering methods to direct stem cell fate and have therefore a significant impact in tissue repair technologies and regenerative medicine.";1903330;1903330;ERC-2014-CoG;ERC-COG;POLITECNICO DI MILANO;IT;Istituto di Ricerche Farmacologiche Mario Negri;IT; 194470;646769;TUNEMEM;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Externally Tuneable Separations for Membrane Reactors;1/08/2015;31/07/2020;;"I will develop an all new type of reactor for pharmaceutical and chemical process applications the tuneable membrane reactor. These contain ground-breaking conducting polymer composite membranes that will allow in-situ tuning of the molecular selectivity for both neutral and charged species through them. This is revolutionary: current state-of-the-art membranes can be electrically tuned for charged species only. The project is timely, developing a new technology that can give the EU a competitive advantage for our declining pharmaceutical and (petro)chemical manufacturing base and builds on my recent research innovations.

To do this, my team of 3 PDRAs, 3 PhDs and I will develop unique stable polymer-polymer acid-nanoparticle composite membranes that can be externally electrically tuned to different pore sizes and/or molecular selectivity, uniquely tuning for neutral and charged species. We will characterise the chemical, physical and transport mechanisms responsible for the membrane tuneablity and relate these to transport models. We will then determine the feasibility of applying these unique tuneable membranes into membrane reactors, to allow in-situ external control of two key reactor parameters currently not possible: (1) Membrane fouling - membrane pore size/free volume and charge will be changed by applied potential allowing the fouling layer to be pushed off/through the membrane. (2) Precise external control of the reactant and product spectrum in the reactor by modifying species retention. By doing this, these tuneable membranes can be used to control the reaction rate, emissions and catalyst retention to maximise reaction rate and selectivity. This increases energy efficiency and emission control, helping the EU 20-20-20 environmental targets to be met. The overall impact applies beyond the project we will be able to increase the control of membrane separations used worldwide, helping industries including food, water, healthcare and chemicals.";1996946;1996946;ERC-2014-CoG;ERC-COG;UNIVERSITY OF BATH;UK;;; 194798;652635;PLATFORM2;SIGNED;H2020-EU.3.2.;ISIB-10-2014;H2020;Platform of bioeconomy ERA-NET Actions;1/03/2015;28/02/2018;;"PLATFORM brings together ERA-NETs in the area of the bioeconomy. The current proposal will continue and expand the work of FP7 PLATFORM (2012-2014) with the following objectives: to further increase collaboration among actors, to foster inclusiveness, to increase capacities for efficient and effective ERA-NETs, and to inform research policy making.

FP7 PLATFORM organised inspiring annual events, dedicated workshops, a master class for call managers, fruitful two-way interaction with the Commission, the EIP AGRI and with the BBI-JU, and produced a comprehensive book about the bioeconomy ERA-NETs and their activities. Surveys, analysis and events also engaged ERA-NETs from neighbouring themes with bioeconomy relevance, JPIs Oceans and FACCE, SCAR WGs, and self-sustained ERA-NETs.

PLATFORM2 will build on these activities and will further strengthen mutual learning, maximise synergies and increase coordination. PLATFORM2 will expand the network to new ERA-NET actions (Cofund), to more JPIs and will also seek stronger interaction with SCAR. On the website, a searchable database on bioeconomy ERA-NET joint calls will be constructed, including statistics and impact assessments, such as on leverage. Data may flow into other data repositories, e.g. an EIP Agri database on projects in the area of agriculture. A World Caf workshop is scheduled to ponder new, sustainable and alternative models for cooperation between public research programmes. PLATFORM2 will make an inventory of alignment actions taken by ERA-NETs. The series of Annual Events will be continued and enable actors to discuss emerging cooperation needs, opportunities and tools. PLATFORM2 will foster inclusiveness in all its work, in particular by a master class directed at new Member States and sessions at the Annual Events on improving both involvement and performance. Capacities will be increased by sharing experience and by way of master classes on planning and managing (Cofund) calls, as well as through evaluation and monitoring of ERA-NETs. The reflections and recommendations will be summarised in policy briefs.";499593,75;499593;H2020-ISIB-2014-1;CSA;STICHTING WAGENINGEN RESEARCH;NL;"MINISTERO DELLE POLITICHE AGRICOLE ALIMENTARI E FORESTALI;FORSCHUNGSZENTRUM JULICH GMBH;AARHUS UNIVERSITET;Fachagentur Nachwachsende Rohstoffe e.V.;MINISTERIE VAN ECONOMISCHE ZAKEN;BUNDESMINISTERIUM FUER LAND-UND FORSTWIRTSCHAFT UMWELT UND WASSERWIRTSCHAFT;INNOVATIONSFONDEN;Ministrstvo za izobrazevanje, znanost in sport";"IT;DE;DK;NL;AT;SI"; 194491;647276;MARS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Electronic Order, Magnetism, and Unconventional Superconductivity probed in Real-Space;1/09/2015;31/08/2020;;"The interplay of electronic order with antiferromagnetism and superconductivity has recently emerged as a vital question for rationalizing the physics of all classes of unconventional superconductors. The electronic order is rarely sufficiently long-range correlated to render it susceptible for diffraction techniques. Instead, a local probe is usually required to detect it experimentally. It is clear, however, that such a probe must provide sensitivity at the same time to electronic order, superconductivity, and static magnetism for clarifying the interplay between these ordering phenomena. The only experimental technique which is capable of fulfilling these requirements simultaneously is spin-polarized scanning tunneling microscopy (SP-STM). This technique utilizes spin-polarized tunneling currents in order to measure signatures of electronic order, superconducting gaps, and the magnetic structure at the atomic scale. To the best of our knowledge, SP-STM has never been applied to unconventional superconductors, despite the mandatory necessity.

Exactly this is the goal of the MARS project: We want to combine SP-STM, which we recently established in our microscopes, with our experience in scanning tunneling microscopy on unconventional superconductors. We will apply highest-resolution SP-STM systematically to prototype representatives of the most important classes of unconventional superconductors, viz. cuprate, iron-arsenide, and heavy-fermion superconductors. For this purpose, a unique milli-Kelvin scanning tunneling microscope will be built, in order to achieve unprecedented resolution in spin-polarization, energy, and real-space.";2747025;2747025;ERC-2014-CoG;ERC-COG;LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V.;DE;;; 194574;649378;FIRES;SIGNED;H2020-EU.3.6.;EURO-2-2014;H2020;Financial and Institutional Reforms for the Entrepreneurial Society;1/06/2015;31/05/2018;;In this project we will analyse the broader contexts of smart, inclusive and sustainable growth in Europe to support implementation of the Commissions 'Europe 2020' growth strategy and to restore Europes ability to innovate, grow and create jobs over the coming decades. In this proposal we argue that entrepreneurship must play a central role in that effort. 'Entrepreneurship' tends to make people think of the US and its model of high growth and high-tech start-ups in Silicon Valley. We are keenly aware, however, that a European growth agenda requires a focus on European entrepreneurship. US recipes and models will not fit the European context and do not deliver the results Europe wants. Our project's objective is therefore to thoroughly analyse European institutional arrangements and their current (in)ability to mobilise Europes human, financial and knowledge resources for entrepreneurial activity. This will help us formulate an effective reform strategy to reinvigorate European economies. The current diversity of institutional arrangements in Europe has long and common historical roots that must first be recognised and understood. Based on common global trends in technology and competition, we then establish the urgency and desirability for making the transition to a more entrepreneurial economy throughout Europe. Once this has been established, our project will develop and provide the tools for policy makers to assess the quality of national and regional entrepreneurial ecosystems and to identify the main strengths and weaknesses with regard to making the transition. Based on this assessment we will formulate specific proposals to enhance the allocation of talent, finance and knowledge to new value creation and we will conclude our project with a legal analysis to see where competencies currently lie and what action could be taken.;2544641;2544641;H2020-EURO-SOCIETY-2014;RIA;UNIVERSITEIT UTRECHT;NL;"LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;FRIEDRICH-SCHILLER-UNIVERSITAT JENA;Stiftelsen Institutet for Naringslivsforskning (THE RESEARCH INSTITUTE OF INDUSTRIAL ECONOMICS);INSTITUTO SUPERIOR TECNICO;UNIVERSITY OF PIRAEUS RESEARCH CENTER;PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS;POLITECNICO DI MILANO;KATHOLIEKE UNIVERSITEIT LEUVEN";"UK;DE;SE;PT;EL;HU;IT;BE"; 194449;646511;REMOURBAN;SIGNED;H2020-EU.3.3.1.3.;SCC-01-2014;H2020;REgeneration MOdel for accelerating the smart URBAN transformation;1/01/2015;31/12/2019;;"REMOURBAN aims at the development and validation in three lighthouse cities (Valladolid-Spain, Nottingham-UK and Tepebasi/Eskisehir-Turkey) of a sustainable urban regeneration model that leverages the convergence area of the energy, mobility and ICT sectors in order to accelerate the deployment of innovative technologies, organisational and economic solutions to significantly increase resource and energy efficiency, improve the sustainability of urban transport and drastically reduce greenhouse gas emissions in urban areas. The urban renovation strategy will be focused on the citizens, because they become the cornerstones to making a smart city a reality and will not only be the most affected by the improvements but also they will be the common factor of each of them.

HOW THE OBJECTIVE WILL BE ACHIEVED
1. Developing a sustainable urban regeneration model, considering a holistic approach, which supports the decision making of the main stakeholders for addressing wide renovation and city transformation processes.
2. Validating the urban regeneration model by means of large scale interventions on several cities called lighthouse cities, Valladolid, Nottingham and Tepebasi/Eskisehir (more than 1.000 dwellings retrofitted, more than 190 EV deployed and a total investment higher than 14 M).
3. Guaranteeing the replicability of the model at European level. Two cities will be also involved in the consortium, called follower cities, Seraing (Belgium) and Miskolc (Hungary) and will be developed a procedure for assessing the replicability potential of the model.
4. It is planned an intense activity focused on generating exploitation and market deployment strategies to support the commercial exploitation of the project outcomes.
5. It will be deployed a powerful communication and dissemination plan. This plan will integrate a citizen engagement strategy and will disseminate the benefits of the project to a wide variety of audiences (more than 11.000 citizens engaged).";23791529,88;21541949,13;H2020-SCC-2014;IA;FUNDACION CARTIF;ES;"XERIDIA S.L.;SASIE Ltd;GRUPO MECANICA DEL VUELO SISTEMAS SA;ANADOLU UNIVERSITY;VEOLIA SERVICIOS LECAM SOCIEDAD ANONIMA UNIPERSONAL;DEMIR CANER;YOURIS.COM;AYUNTAMIENTO DE VALLADOLID;Nottingham City Council;IBERDROLA INGENIERIA Y CONSTRUCCION SAU;OLCSAN CAD TEKNOLOJILERI YAZILIM DONANIM DANISMANLIK SANAYI VE TICARETANONIM SIRKETI;INFOHUB Ltd;OFFICINAE VERDI SPA;STEINBEIS INNOVATION GGMBH;ENERGON ENERJI VERIMLILIGI DANISMANLIGI HIZMETI VE TICARET LIMITED SIRKETI;MISKOLC HOLDING ONKORMANYZATI VAGYONKEZELO ZARTKORUEN MUKODO RESZVENYTARSASAG;THE NOTTINGHAM TRENT UNIVERSITY;ACCIONA CONSTRUCCION SA;ASSOCIATION POUR LE REDEPLOIEMENT ECONOMIQUE DU BASSIN SERESIEN - AREBS;THE NOTTHINGHAM ENERGY PARTNERSHIP LBG;TEPEBASI MUNICIPALITY";"ES;UK;TR;BE;IT;DE;HU"; 194533;648330;TIAMO;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Trapping Ions in Atoms and Molecules Optically;1/08/2015;31/07/2020;;"Isolating ions and atoms from the environment is essential in experiments on a quantum level. For decades, this has been achieved by trapping ions with radiofrequency (rf) fields and neutral particles with optical fields. Our group demonstrated the trapping of ions by interaction with light. We see these results and our proposal as starting point for finally combining the advantages of optical trapping and ions. In particular, ions provide individual addressability, high fidelities of operations and long-range Coulomb interaction, significantly larger compared to those of atoms and molecules
The aim of this proposal is to (i) study and establish optically trapping of ions and atoms in general, to (ii) demonstrate the substantial improvement of our approach in the context of interaction and reaction at ultra-low temperatures and to (iii) explore further perspectives by adapting methodology of quantum optics to gain control and state-sensitive detection on the level of individual quanta within the merged ion-atom system.
The field of ultra cold chemistry is perfectly suited as a showcase for this purpose. We will embed optically trapped ions into quantum degenerate gases to reach temperatures, 4-5 orders of magnitude below the current state of the art. Our approach circumvents the currently inevitable excess kinetic energy in hybrid traps, where ions are kept but also driven by rf-fields. It permits to enter the temperature regime where quantum effects are predicted to dominate, (i) in many-body physics, including the potential formation and dynamics of mesoscopic clusters of atoms of a Bose-Einstein-Condensate, binding to the impurity ion, as well as (ii) the subsequent two-particle s-wave collisions, the ultimate limit in ultra-cold chemistry.

Further development of our novel and generic tools for quantum engineering can be expected to propel several other striving fields of research, such as, experimental quantum simulations";1792500;1792500;ERC-2014-CoG;ERC-COG;ALBERT-LUDWIGS-UNIVERSITAET FREIBURG;DE;;; 194823;652938;TELE;SIGNED;H2020-EU.1.3.2.;MSCA-IF-2014-EF;H2020;DOES IT PROMOTE ECONOMY AND WELL-BEING? THE IMPACT OF TELEWORKING ON ENVIRONMENT AND LABOUR MARKET OUTCOMES;1/06/2015;31/05/2017;;"This project examines the telework effects on environment and labour market outcomes. More specifically, the first aim of the project is to analyse the link between job satisfaction, labour productivity and firm performance. The second aim is to examine the effects of teleworking on labour productivity/job satisfaction and environment (e.g. traffic, air pollution). The final aim of this study is to examine how teleworking affects the labour market and housework division between men and women. Two databases are used; the Workplace Employment Relations Survey (WERS) and British Household Panel Survey (BHPS). Various econometric techniques are applied, such as Fixed Effects and Dynamic Generalized Methods of Moments (GMM) models Instrumental Variables (IV) and Generalized Latent Class Ordered Probit Models, Seemingly Unrelated Regressions (SURE) and Three Stage Least Squares (3SLS).";168277,2;168277,2;H2020-MSCA-IF-2014;MSCA-IF-EF-ST;ARC-Net Applied Research On Cancer Centre, University of Verona;IT;;; 194579;649435;TransSOL;SIGNED;H2020-EU.3.6.;EURO-3-2014;H2020;European paths to transnational solidarity at times of crisis: Conditions, forms, role-models and policy responses;1/06/2015;31/05/2018;;"TransSOL is committed to the systematic, interdisciplinary and praxis-oriented analysis of European solidarity in times of crisis. It has three overarching objectives: (a) it will map and analyse solidarity in Europe by means of a cross-national database that comprises three surveys addressing the general population, organized civil society, and claims-making in the media; (b) it will gather systematic data on the contextual factors and engage into political and legal analyses to ascertain the influence of the socio-economic, political, and legal context on solidarity, in particular the impact of the crisis, the EUs political responses and target-groups specific public policies; and (c) it will identify and develop best practices of transnational solidarity, draft evidence-based policy recommendations, and engage proactive dissemination and communication activities. The project comprises teams from Denmark, France, Germany, Greece, Italy, Poland, Switzerland and the UK, including scientists from various disciplines and civil society practitioners, thus promising to deliver interdisciplinary and comparative analyses, knowledge-transfer and evidence-based, practicable recommendations.
The project will enable us to address the three topics of the call. First, TransSOL will provide the first rigorous and comprehensive analysis of transnational solidarity in Europe, its main forms, conditioning factors (e.g., individual features as gender and social class, spatial inequalities, and contextual factors), and underlying conflicts about contending norms, identities, and interests. Secondly, the project will address the impact of Europes cultural diversity and multiple identities on European solidarity by analysing public claims-making and debates within the media. And finally, we engage into a critical reflection about adequate policy responses, in particular about the potentials of social investments balancing civic virtues of solidarity with public responsibilities.";2847680;2483805;H2020-EURO-SOCIETY-2014;RIA;UNIVERSITAET SIEGEN;DE;"UNIWERSYTET WARSZAWSKI;PANEPISTIMIO KRITIS;FONDATION NATIONALE DES SCIENCES POLITIQUES;KOBENHAVNS UNIVERSITET;EUROPEAN ALTERNATIVES LIMITED LBG;EUROPEAN ALTERNATIVES BERLIN E V;UNIVERSITA DEGLI STUDI DI FIRENZE;THE UNIVERSITY OF SHEFFIELD;UNIVERSITE DE GENEVE;THE GLASGOW CALEDONIAN UNIVERSITY";"PL;EL;FR;DK;UK;DE;IT;CH"; 194391;645771;EMERGENT;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;ChiplEss MultisEnsor Rfid for GrEen NeTworks;1/01/2015;31/12/2017;;"EMERGENT takes up the broader scope of Marie Sk?odowska-Curie Research and Innovation Staff Ex-change Scheme of promoting knowledge-sharing-based cooperation and moves its steps forward to actual-ly support and facilitate the movement of skilled people between academia and industry committed to work on a research topic dealing with green chipless RFID tags and sensors.

EMERGENT will move towards strengthening of existing inter-sectoral networks between the three EU re-search institutes and the three EU SMEs involved by implementing a total of 68 knowledge transfer se-condments in order to facilitate the joint research and innovation work aiming to realize a new class of chipless RFID tags and sensors moving from conventional sensors towards next generation pervasive interconnected systems by employing environmental-friendly substrates such as paper and low-cost printing process.

EMERGENT will design hand in hand with both the chipless tag and sensor a dedicated reader for extracting the desired information. To this aim, novel signal processing algorithms will be developed and tested. EMERGENT will focus on system parameters of prominent relevance reliability, calibration) to assess the true performance of the tag, and to make comparisons among different implementations. The critical issues regarding the sensitivity and resolution of the reader will be carefully addressed and solved.

EMERGENT will deliver wireless passive chipless smart tags and sensors able to sense the changing environment by collecting information about quantities of interest which may include temperature, humidity, stress, gases. EMERGENT will enhance the performance and robustness of chipless RFID sys-tems and will bring RFID sensing outside research laboratories towards self-consistent products.";913500;913500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DI PISA;IT;"UNIVERSITAT ROVIRA I VIRGILI;Consortium Ubiquitous Technologies S.c.a.r.l.;ARDEJE SARL;GENERATION RFID S.L.;INSTITUT POLYTECHNIQUE DE GRENOBLE";"ES;IT;FR"; 194518;647723;Earth core;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Exploring Thermodynamic Properties of Earths Core-Forming Materials;1/06/2015;31/05/2020;;"It is known that the Earths core is less dense than pure iron by about 7%, which is due to the presence of a light element(s) such as Si, S, C, O, and H. The goal of this project is to construct a thermodynamic model of the Earths central core. A particular focus is on the identification of the light element because the inclusion of these elements in iron liquid depends on the pressure (P), temperature (T), and chemical environment and hence provides us invaluable information about the origin and evolution of the solid Earth. We will examine phase relations and density of phases in Fe-light element systems by conducting high-P-T experiments and employing thermodynamic calculations based on the experimental data.
High-P-T experiments will be conducted in a diamond anvil cell with three different kinds of heating techniques: laser heating, external-resistive heating, and internal-resistive heating. Of the three, the internal-resistive heating system is a special technique that I have developed and employed and I am currently generating 5000 K at 200 GPa with it. Structure of phases will be analysed by in-situ X-ray diffraction. Chemical analysis will also be employed on samples to determine element partitioning between the phases.
I will also employ thermodynamic calculations based on the experimental data to fully understand the thermodynamic properties of the materials and obtain physical properties which are difficult to directly determine by experiment such as sound velocity of liquids.
From the thermodynamic models, I will calculate the physical properties of light element-bearing iron liquids and compare them with seismologically constrained values of the Earths core to find out the best matching composition. From these results, I will discuss the physical and chemical environments during the core formation and implicate in the origin and evolution of the Earth. Also the results will be applied to other terrestrial planets which have metallic cores.";1891765;1891765;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF EDINBURGH;UK;;; 194501;647455;RegulRNA;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Modulation of RNA-based regulatory processes by viruses;1/01/2016;31/12/2020;;Small and large non-coding RNAs are essential components at the heart of gene expression regulation. The past fifteen years have witnessed the emergence of a new field of research impacting diverse domains of biology. Among these, virology is no exception and discoveries such as the antiviral role of RNA silencing, virus-encoded microRNAs (miRNAs), or miRNA-based regulation of viruses have notably shifted our views of host-virus interactions. Although we know a lot about the mechanisms of action of ncRNAs, and their role in the context of viral infections, we know much less regarding the control of the regulatory RNAs themselves. In other words, how are the regulators regulated? To provide answers to this burning question, we propose to use different viruses as models to investigate the various levels where modulation of regulatory RNA can occur. Thus, we will study the importance of RNA secondary and tertiary structure as well as accessory proteins in the regulation of miRNA primary transcript processing. In a second axis, we propose to investigate how the functional, mature miRNAs can be controlled. To this end, we will focus on the mechanisms of target-mediated miRNA decay and the role of competing endogenous RNAs. We will finally turn to the regulation of antiviral RNA silencing. Although it seems that this kind of defence mechanism exist in mammalian cells, it is not yet clear how physiologically relevant it is and how it interfaces with other innate immune mechanisms. In this multidisciplinary project, we will use a combination of techniques ranging from bioinformatics to cellular biology to achieve our goal to get a comprehensive view of how RNA silencing processes are regulated during virus infection.;1998291;1998291;ERC-2014-CoG;ERC-COG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194465;646650;SINGWAVES;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Singularity formation in nonlinear evolution equations;1/08/2015;31/07/2020;;'Non linear wave equations are central in the description of many canonical models in physics from nonlinear optics to fluid mechanics. A phenomenon of particular interest is singularity formation which corresponds to the concentration of the energy of the wave packet. The existence and description of such dynamics is still mostly mysterious, but fundamental progress have been made in the past ten years on canonical models like nonlinear wave and Schr\'odinger equations, with in particular the discovery of the fundamental role played by a specific class of nonlinear wave packets: the solitary waves. These very recent works open up a huge field of investigation on problems which were considered out of reach ten years ago. The aim of the SINGWAVES project is to strenghten our research group in the setting of an intense international activity with two main directions of investigation: the construction and classification of singular bubbles for some canonical models like non linear Schr\'odinger equations, the exploration of new deeply nonlinear dynamics in connection with classical models at the frontier of current research.';1211055;1211055;ERC-2014-CoG;ERC-COG;UNIVERSITE DE NICE SOPHIA ANTIPOLIS;FR;;; 194655;650292;ELINKKER;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Solutions for TCO optimized electrification of city bus systems;1/10/2014;31/03/2015;;"Linkker has developed total cost of ownership (TCO) optimized concept for electrification of city bus systems. Linkker solutions are lightweight city bus, energy efficient battery electric vehicle systems (BEV system) and conversion kits for bus retrofits.

Objective of 1st phase of commercialization is to study commercial potential of energy efficient bus system developed by Linkker in European cities. Speed up roll-out of energy efficient electric bus systems in a few selected cities in Europe for reduced emissions and lower TCO (Total Cost of Ownership). Faster transition will help cities achieve cost savings for public transportation quicker, reduce emissions faster and finally accelerate electric bus activities by European industry. This is our focus in Phase 1.

Long term objective is together with cities and bus operators to increase attractiveness of public transport with sustainable electric buses, which offer superior user experience.";71429;50000;H2020-SMEINST-1-2014;SME-1;LINKKER OY;FI;;; 194657;650381;COMAWARE;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;COMmunication and Assessment With Adaptive Realtime Environments;1/10/2014;31/03/2015;;"Our overall objective is to provide both new brain-computer interface (BCI) technologies and an innovative business model focused on user-centered assessment and communication for persons with disorders of consciousness (DOCs). We have recently shown that present clinical tools to assess DOC are inadequate. Across different studies, up to 43% of patients who had been designated as nonresponsive (including in a vegetative state (VS) or minimally conscious state (MCS) were in fact able to communicate through new BCI systems developed for such patients. For example, patients could produce reliable changes in motor activity in the EEG when asked via headphones to imagine left hand movement or walking through the house if their father was named (the correct name). In related work, patients could produce differential responses to YES/NO/SKIP questions (based on the P300 component) by counting vibrations of one out of three different tactors placed on the body. This creates a pressing social and economic challenge to provide more accurate information about these patients cognitive abilities to families, clinicians and the patients themselves about their long-term options. By providing BCI-based assistive technology (AT) for communication and control, we will allow patients to not only make their own decisions but also interact with their environments, the internet and other people, fostering inclusion and accessibility.
The main outcome will be a life-changing experience for many patients: being recognized as someone who can communicate. They will once again be able to convey their needs and desires to carers, and may influence decisions about therapy, end-of-life, living environments, long term care and use of ComAware products and services. Carers and medical staff will be able to better identify patients needs and provide care and help accordingly. Family and friends will again be able to communicate with someone they had been (mistakenly) told could not communicate.";71429;50000;H2020-SMEINST-1-2014;SME-1;GUGER TECHNOLOGIES OG;AT;;; 194476;646894;TRACES;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Tracing ancient microbial cells embedded in silica;1/05/2015;30/04/2020;;"Reconstructing the nature and habitat of early life is a difficult task that strongly depends on the study of rare microfossils in the ancient rock record. The preservation of such organic structures critically depends on rapid entombment in a mineral matrix. Throughout most of Earths history the oceans were silica-supersaturated, leading to precipitation of opal deposits that incorporated superbly preserved microbial cells. As we trace this record of life back in deep time, however, three important obstacles are encountered; 1) microorganisms lack sufficient morphologic complexity to be easily distinguished from each other and from certain abiologic microstructures, 2) the ancient rock record has been subjected to increased pressures and temperatures causing variable degradation of different types of microorganism, and 3) early habitats of life were dominated by hydrothermal processes that can generate abiologic organic microstructures. TRACES will study the critical transformations that occur when representative groups of microorganisms are subjected to artificial silicification and thermal alteration. At incremental steps during these experiments the (sub)micron-scale changes in structure and composition of organic cell walls are monitored. This will be compared with fossilized life in diagenetic hot spring sinters and metamorphosed Precambrian chert deposits. The combined work will lead to a dynamic model for microfossil transformation in progressively altered silica-matrices. The critical question will be answered whether certain types of microorganisms are more likely to be preserved than others. In addition, the critical nano-scale structural differences will be determined between abiologic artefacts such as carbon coatings on botryoidal quartz or adsorbed carbon on silica biomorphs and true microfossils in hydrothermal cherts. This will provide a solid scientific basis for tracing life in the oldest, most altered part of the rock record.";1999250;1999250;ERC-2014-CoG;ERC-COG;INSTITUT DE PHYSIQUE DU GLOBE DE PARIS;FR;;; 194455;646555;ENERGISE;SIGNED;"H2020-EU.3.;H2020-EU.3.3.;H2020-EU.3.3.4.";LCE-07-2014;H2020;ICT-based ENERgy Grid Implementation Smart and Efficient;1/01/2015;31/03/2017;;"ENERGISE sets out to facilitate the efficient deployment of smart grid solutions by offering to all relevant stakeholders telecommunication providers; industry associations in the telecommunications and utility sectors; energy suppliers; energy industry associations; national regulatory agencies; ministries of Member States; other players being active in the relevant fields a toolkit that supports their decision-making process as regards the use of telecommunication infrastructure for existing or projected business cases. Based on existing experience the consortium can deliver a particularly suitable toolkit that is based upon a broad survey of actual use cases. Concretely, the ENERGISE toolkit addresses the following issue.
Smart grid solutions hold immense opportunities for both European businesses as well as society as a whole and contribute substantially to achieving the objectives of a low carbon economy. Telecommunication infrastructure constitutes a vital part of any smart grid solution. Given the penetration of telecommunication infrastructure in Europe, it is likely that significant synergies can be achieved in the process of implementing smart grid solutions if existing telecommunication infrastructure can be used.
Identifying specific cases or business models, where shared infrastructure use is beneficial, is difficult for all stakeholders. ENERGISE sets out to solve this issue by providing energy suppliers and telecommunication providers as well as policy makers with a decision-supporting toolkit.
This toolkit will be able to account for all relevant framework conditions and will deliver useful advice to relevant stakeholders based on a broad survey of and exchange about existing use cases for smart grid solutions including a thorough cost-benefit analysis. Insights gained from the toolkit will enable a more evidence-based appreciation of innovative business for both innovators in the private sector and research and innovation policy makers.";998000;998000;H2020-LCE-2014-3;CSA;TUEV RHEINLAND CONSULTING GMBH;DE;WIK WISSENSCHAFTLICHES INSTITUT FUER INFRASTRUKTUR UND KOMMUNIKATIONSDIENSTE GMBH;DE; 194783;652593;odis;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014;H2020;Ensygnia Onescan Market Disruptive Technology;1/04/2015;30/09/2016;;"Ensygnia Onescan Open Disruptive Innovation Scheme
If awarded the 500,000 grant, Ensygnia would use it to accelerate the companys market disruption activity in Europe. This would involve expansion by hiring key Business Development and Sales Executives to engage with target companies across Europe and increase awareness Ensygnias Onescan platform and App.

Onescans patented process will fuel the uptake of mobile payments and also has applications for transaction authentication and logon services. Onescan introduces new levels of enhanced security coupled with ease of use factors which have the power to revolutionise the payments landscape.

Ensygnias progress so far has already been recognised within the mobile and payments industries:
Mobile Industry Awards: Best Software Solution Ensygnia [June 2014]
UK winner in the Innotribe start up challenge 2014 organised by SWIFT the banking industry group. We will now take part in the global Innotribe finals in Boston later this year
Voted by the audience at the Mobile World Congress as one of the top three companies most likely to have the greatest impact on the global mobile industry over the next ten years (March 2013)

In Europe, Ensygnia will first look to target Spain, Germany, and France. We have both a direct and an indirect customer acquisition strategy. We are targeting companies with large customer bases so will work with key partners where necessary but can also deal direct. We aim to create an eco-system of consumers able to use the Onescan App to make payments online and in-stores anywhere in Europe and beyond. Onescan securely associates identity with transactional information both personal and financial - and has the power to disrupt traditional methods of payment, and other vertical market applications, on a global scale.";10477921,25;500000;H2020-SMEINST-2-2014;SME-2;ENSYGNIA LIMITED;UK;;; 194559;649149;EuroMED-IMWC;SIGNED;H2020-EU.3.6.;Europe;H2020;EuroMED Cooperation. Inland and Marine Water Challenges;1/07/2014;31/12/2014;;"The project supports the organization of the Italian Presidency event EuroMED cooperation. Inland and Marine Water Challenges, strongly emphasizing Mediterranean cooperation on research and innovation. In the framework of the ENP and the UNEP/MAP Barcelona Convention and in line with H2020 work-programme, the event is designed as a two day conference embracing present political debate for the identification of urgent challenges to advance the frontier of science and to foster technological innovation to sustain economic growth and EuroMED cooperation. The event - to be held in Naples in September 2014 - offers the unique opportunity to underline the links between inland and marine waters, with special emphasis to the impacts that such a link has on society and economic growth, particularly in a Region whose relevant economic activities like fishery, agriculture, and coastal and marine tourism are clearly affected by the water management issue. As milestone towards the definition of a roadmap to tackle these objectives, on the first day four parallel workshops will address: (1) Water resources and land management impacts on inland and sea water in the Mediterranean Region; (2) A Mediterranean integrated Ocean observing system to support sustainable coastal and marine tourism; (3) Building Ecosystem based approach to Fishery and Aquaculture in the Mediterranean Sea; (4) Ecosystem-Based Management (EBM) in the Mediterranean Region. On the second day, a plenary session will finally deliver the key output message. In order to guarantee the effectivness of the event, different stakeholders from public and private sector will actively be involved in the organization, including policy makers at Ministry level and private companies. Besides Member States and international organizations, a broad participation of representatives from non-EU countries is expected. To maximize the impacts strong efforts will be also devoted to communication and dissemination activities.";125500;100000;H2020-Adhoc-2014-20;CSA;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;;; 194434;646260;R2R Biofluidics;SIGNED;H2020-EU.2.1.2.1.;NMP-04-2014;H2020;Large scale micro-and nanofabrication technologies for bioanalytical devices based on R2R imprinting;1/02/2015;31/01/2019;;"Roll-to-roll (R2R) technologies are mature core processes in manufacturing lines for graphical printing industry. In several other areas (e.g. electronics or optics) R2R techniques are emerging, being expected to notably lower the unit prices of flexible devices.

In particular, recently developed roller-based nanoimprinting methods enable unrivalled throughput and productivity for precise fabrication of micro- and nanoscale patterns.
Areas that will benefit strongly from adopting such R2R nanoimprinting technologies are microfluidics and lab-on-chip products for diagnostics, drug discovery and food control. Such devices require combined printing of micro- and nanostructures and large quantities at low unit costs.

The project R2R Biofluidics aims on the development of a complete process chain for first-time realization of production lines for two selected bioanalytical lab-on-chip devices based on high-throughput R2R nanoimprinting in combination with complementary printing and manufacturing technologies.

Two types of demonstrators will be fabricated targeting application areas, which would clearly benefit from technology advancement in high volume manufacturing, show large potential for commercial exploitation and adopt current standard formats (microtiter plate and microscope slides).

Demonstrator 1 will represent an in-vitro diagnostic (IVD) chip suitable for point-of-care applications, showing improved sensitivity thanks to imprinted nanoscale optical structures and microfluidic channels. R2R fabrication will further greatly reduce production costs and increase manufacturing capacity with respect to currently used products.

Demonstrator 2 will provide a device for improved neuron based high-throughput screening assays in drug development. It will consist of nano to microstructured, interconnected channels in combination with dedicated biofunctionalized surfaces for alignment and controlled growth of neurons.";7929411;6421672,57;H2020-NMP-PILOTS-2014;IA;JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH;AT;"GREINER BIO-ONE DIAGNOSTICS GMBH;FUNDACION TECNALIA RESEARCH & INNOVATION;MICRO RESIST TECHNOLOGY GESELLSCHAFT FUER CHEMISCHE MATERIALIEN SPEZIELLER PHOTORESISTSYSTEME MBH;INMOLD AS;BIONIC SURFACE TECHNOLOGIES GMBH;Innovative Technologies in Biological Systems;BIFLOW SYSTEMS GMBH;BIONANONET FORSCHUNGSGESELLSCHAFT MBH;EV GROUP E. THALLNER GMBH";"AT;ES;DE;DK"; 194564;649200;E-saving Ultrasonics;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Energy-saving and reducing carbon emissions by applying advanced ultrasonic technology to industrial maintenance services for compressed air systems;1/10/2014;31/03/2015;;"SONOTEC aims to develop innovative ultrasonic measurement devices and sensors primarily applied to highly improved methods for leak detection and estimation of the degree of energy-loss in compressed air systems to facilitate the reduction of energy-waste and carbon emissions among industries.

Compressed air is accounted for about 10 % of industrial consumption of electricity in the world. Estimates indicate direct accountability to an annual electricity consumption of over 120 TWh (>90 million tons of CO2) in the EU and over 760 TWh (>570 million tons of CO2) worldwide. Alarming ~30 % of the energy used in compressed air systems is wasted due to leakages. Prevention and repair of leaks are emphasized as the means with highest savings potential (over 42 %). Estimated reductions of energy-waste of over 15 TWh and carbon emissions of over 11 million tons of CO2 per year could be achieved by leak detection and repair only in the EU.

Technologies based on non-harmful ultrasound are commonly used in almost every sector of industrial maintenance. Though existing technology and methods be applied to leak detecting and evaluation in compressed air systems are greatly simplified and not adequate to provide realistic estimations of the physical nature and size of leakages.

SONOTECs realisation of an innovative product will be in form of a novel mobile/handheld device with modular equipment combining modern components for air ultrasonic sensors, measurement principles, testing procedures, embedded IT and a flexible interface for user-oriented maintenance management. Basic research has been completed and prototypes are successfully developed (TRL 6/7). The new sensor materials based on piezoelectric composites provide higher sensitivity and broader frequency range meeting the requirements for advanced maintenance services of modern industries to reduce energy-waste as well as carbon emissions and accordingly production costs.";71429;50000;H2020-SMEINST-1-2014;SME-1;SONOTEC ULTRASCHALLSENSORIK HALLE GMBH;DE;;; 194511;647850;OCTAVE;SIGNED;H2020-EU.3.7.;DS-02-2014;H2020;Objective Control for TAlker VErification;1/06/2015;31/07/2017;;"Industry needs alternatives to textual passwords for access control. While tokens can still be stolen or transferred to other persons, biometrics technology can provide reliable, cost-effective and user-friendly solutions.
The proliferation of smart services calls for unsupervised authentication at a distance. Being natural, non-intrusive and readily compatible with smart and mobile devices, automatic speaker verification (ASV) is an appealing solution. Even so, todays state-of-the-art ASV systems lack robustness to environmental variability and are vulnerable to spoofing. Concerns regarding interoperability, scalability and privacy also form barriers to exploitation.
While embracing standards, in addition to a privacy and interoperability-by-design ethos, OCTAVE will integrate commercial-grade and new, hybrid ASV systems with the latest environmental robustness and anti-spoofing technologies to deliver a scalable, trusted biometric authentication service (TBAS). While simultaneously relieving end-users from the inconvenience of dealing with textual passwords, the OCTAVE platform will reduce the economic and practical burdens related to password loss and recovery. The TBAS will support single (text-dependent, text-prompted and text-independent) in addition to hybrid operating modes. The delegation of authentication to a single, yet distributed TBAS, will increase trust and privacy, avoid single points of failure and allow for rapid breach notification and remediation.
Solutions will be installed in data-sensitive and mission-critical services and validated in two real commercial trials: banking services and physical access within a critical airport infrastructure. Flexibility will support wider exploitation in future applications in, for example, customer care, telephone banking, e-commerce, logical and physical access control. OCTAVE will thus fuel new opportunities for commercial services making use of electronic identification and authentication.";5208985;4406116;H2020-DS-2014-1;IA;FONDAZIONE UGO BORDONI;IT;"ADVALIA SRL;AALBORG UNIVERSITET;APLCOMP OY;EURECOM;SOCIETA PER AZIONI ESERCIZI AEROPORTUALI SEA SPA;ATOS SPAIN SA;VALIDSOFT UK LIMITED;ITA-SUOMEN YLIOPISTO;RESEARCH AND EDUCATION LABORATORY IN INFORMATION TECHNOLOGIES;The University of Hertfordshire;FINDOMESTIC BANCA SPA";"IT;DK;FI;FR;ES;UK;EL"; 194502;647471;SUPERNEMS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Superconducting Diamond Quantum Nano-Electro-Mechanical Systems;1/07/2015;30/06/2020;;"In this project, the fabrication and characterisation of all diamond superconducting Nano-Electro-Mechanical Systems (NEMS) is proposed for the investigation of macroscopic quantum states. This involves state of the art Chemical Vapour Deposition (CVD) of diamond, doping, nanofabrication and modelling of devices. The fundamental properties of superconducting diamond, the associated mechanical properties of diamond NEMS and the characterisation of low temperature and low dimensional quantum effects will be investigated.

Critically, the unprecedented resonant frequencies of diamond cantilevers allow the possibility of cooling cantilever devices down to the ground state. Coupled with its superconducting-based read out possibilities, this material offers new opportunities for challenging the Standard Quantum Limit, the study of quantum entanglement and the fabrication of superconducting diamond Qubits. This work is highly ambitious, as it aims to manipulate systems by exploiting fundamental quantum limits. However, the applicant has already demonstrated the individual constituents of this approach and thus it is not reckless to propose to integrate them.";2734048,75;2734048,75;ERC-2014-CoG;ERC-COG;CARDIFF UNIVERSITY;UK;;; 194808;652682;BioSTEP;SIGNED;H2020-EU.3.2.;ISIB-08a-2014;H2020;Promoting stakeholder engagement and public awareness for a participative governance of the European bioeconomy;1/03/2015;28/02/2018;;The bioeconomy holds potential solutions to important challenges of the future. The social, economic and environmental impacts associated with its products and processes, however, will require extensive dialogue processes on the future development of the bioeconomy. For this purpose, BioSTEP will apply a three-tier approach which aims at reaching all relevant actors in the bioeconomy domain, particularly policy makers, various stakeholder groups (scientists, business, non-governmental organisations, etc.), and citizens. Tailored communication tools, including workshops, conferences and exhibitions, will be developed for each target group in order to maximize outreach and to facilitate active engagement in public debates on the bioeconomy. At a regional level, a living lab approach will be applied and tested, which facilitates the involvement of public-private networks of stakeholders in bioeconomy-based innovation and business model development processes.;1760581,25;1758081,25;H2020-ISIB-2014-1;CSA;ECOLOGIC INSTITUT gemeinntzige GmbH;DE;"WIRTSCHAFT UND INFRASTRUKTUR GMBH & CO PLANUNGS KG;BIOCOM;BALGARSKA STOPANSKA KAMARA - SAYUZ NA BALGARSKIA BIZNES;AGHETERA SAS DI VALE MANFREDI & C;UNIONE REGIONALE DELLE CAMERE DI COMMERCIO INDUSTRIA, ARTIGIANATO E AGRICOLTURA DEL VENETO;THE UNIVERSITY OF NOTTINGHAM;STICHTING WAGENINGEN RESEARCH;UNIVERSITY OF STRATHCLYDE";"DE;BG;IT;UK;NL"; 194642;650027;bettervest;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Crowdfunding for a low carbon energy system: addressing major challenges for EU-wide public and private investments in energy and carbon saving measures;1/10/2014;31/03/2015;;"A low carbon energy system is realizable with current proven technologies provided that appropriate investments for installing these technologies are made. The challenge with energy-efficiency measures is that they require high initial investments and are only profitable in the long run. Thus, many SMEs, non-profit organizations and local authorities cannot afford that or simply lack the interest of investing in these types of actions.
bettervest bridges the gap between funding and action. It is the first crowdfunding platform that focuses on energy-efficiency projects from a size of 5.000 to 200.000 Euros and allows the crowd to benefit from the savings generated through the reduced energy consumption. A defined percentage of the savings is distributed to the crowd until the investment plus a previously agreed upon profit has been completely paid back. Additionally, the project owners can use the crowdfunding project as a customer bonding and staff participation measure that rise awareness for their corporate social responsibility activities and increases identification with the firm.
The Federal Ministry for Economic Affairs and Energy (BMWi) estimates that the benefit of energy-efficiency measures in Germany belongs to 27 Billion Euros in 2012 by avoiding imports of fossil energy carriers. McKinsey estimates that again 850.000 jobs could be generated in the energy-efficiency sector in Germany by 2020. Until 2012 around 500.000 jobs have been generated (BMWi 2014). Applied to the EU these numbers should be multiplied accordingly.
bettervest receives in sum a theoretical impact over an average contract period of five years of 3.750 MWh energy-savings and 4.500 tons carbon reductions for every 1.000.000 Euros funded within the crowd. The already funded projects would not have been implemented without the innovative finance instrument of bettervest.
This proposal aims to explore the opportunity to expand bettervest's activities to other European countries.";71429;50000;H2020-SMEINST-1-2014;SME-1;bettervest GmbH;DE;;; 194486;647106;TUSUPO;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Tubular Supramolecular Polymers: A new class of therapeutic polymers;1/07/2015;30/06/2020;;This research programme will establish a new class of materials and develop them into functional devices for biomedical applications. We will design tubular supramolecular polymers, supramolecular polymer brushes (SPBs), based on the self-assembly of cyclic peptide polymer conjugates. The synergy between the cyclic peptide, which directs the formation of the SPBs and the polymer conjugate, which provides functionality, will open the route to a wealth of new functional structures. We will build on our initial work and expand our research to generate new synthetic routes for the ligation of polymers to peptides, develop new protocols for the characterisation of the materials, and establish the mechanism of supramolecular polymerisation. This research programme will open new horizons in the fundamental understanding and production of supramolecular polymers. In particular, beyond the generation of new materials, the functionality of these systems may allow the development of supramolecular living polymers, a long-standing goal in polymer chemistry that is still elusive. The functionality and versatility of the SPBs obtained in this work open the route to a wealth of applications, and we will focus on one specific target: the fabrication of drug delivery vectors. We will exploit the unique combination of features presented by this new class of polymer therapeutics, such as multiple attachment points for one or more drug(s) / targeting ligands / markers, the ability to self-disassemble into smaller and easy-to-excrete components, and an elongated shape that enables diffusion and interaction with cells more efficiently than traditional globular delivery systems. We will study the pharmacology properties of the SPBs, including their stability, toxicity, mode of cell penetration and ability to deliver a single or a combination of bioactive agent(s) (in the case of concerted mechanisms).;1692376;1692376;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF WARWICK;UK;;; 194461;646604;PeroxiSystem;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Systematic exploration of peroxisomal structure and function;1/09/2015;31/08/2020;;Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental questions remain open. For example, we do not know the entire proteome of peroxisomes, the extent of their metabolic functions, how peroxisomes change to meet cellular requirements or how they interact and communicate with other cellular organelles. In this proposal we suggest to employ our expertise and unique toolsets, successfully applied in the study of whole organelles, to shed new light on peroxisomes as a cellular unit a PeroxiSystem. We propose to combine state-of-the art high content tools with mechanistic studies to uncover new peroxisomal proteins under a variety of growth conditions (Aim1), map the functions of unstudied peroxisomal proteins using both systematic and hypothesis driven approaches (Aim 2) and unravel how peroxisomes communicate with other organelles (Aim 3). To perform these studies we will build on expertise attained during an ERC StG: combining high throughput genetic manipulations of yeast libraries alongside high content screens. Importantly, we will try to bridge the knowledge gap in peroxisomal biology by creating new tools that can be applied to this unique organelle. Our findings should make an important step towards an unprecedented, thorough and multifaceted understanding of peroxisomes, their cellular geography and roles as well as their regulation when presented with various metabolic conditions. More broadly, the approaches presented here can be easily applied to study any organelle of choice, thus providing a conceptual framework in the study of cell biology.;2000000;2000000;ERC-2014-CoG;ERC-COG;WEIZMANN INSTITUTE OF SCIENCE;IL;;; 194376;645740;PRECeDI;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Personalized PREvention of Chronic DIseases;1/01/2015;31/12/2018;;"The aim of the Personalized pREvention of Chronic DIseases consortium (PRECeDI) is to provide high-quality, multidisciplinary knowledge through training and research in Personalized Medicine (PM), with specific reference to prevention of chronic diseases. There is a large consensus that PM is a driver of innovation for research and health care, and also for the health care system and industry as a whole. In order to harness the potential of this new concept, the PRECeDI consortium provides a cohesive framework for training staff from academic and non-academic (NA) institutions on research topics related to PM, with specific reference to the prevention of chronic diseases where there is a lack of substantial evidence, though the potential is huge. The acquisition of skills from staff will come from dedicated secondments aimed at training on research topics not available at the home institutions, and attendance to courses, workshops, seminars, conferences. The goal of secondment is to enable staff to make informed decisions for appropriately serve health care systems, new biotech industries and policy makers at the dawn of the post-genomic era
PRECeDI is a multidisciplinary group of institutions working on different facets of PM, from basic research, to economic evaluations, health service organization, and ethical, social, and policy issues. The consortium is embedded in existing cooperation structures, such as the PerMed project and the Erasmus Mundus ERAWEB II program, with additional leading SMEs in Europe and Canada as beneficiaries. The consortium consists of 8 beneficiaries and 3 partners, of which 7 are academic institutions and 4 NA, including 2 SMEs. During 4-years, 23 ESRs and 7 ERs will be seconded to 11 institutions, where researchers will be supported by a team of leading EU scientists in PM-related disciplines.
In the long run, PRECeDI will foster the integration of PM in the field of prevention, thus contributing to better health for Europes citizen";792000;792000;H2020-MSCA-RISE-2014;MSCA-RISE;Universit Cattolica del Sacro Cuore;IT;"DEBRECENI EGYETEM;STICHTING VU;STICHTING VUMC;LINKCARE HEALTH SERVICES SL;Myriad Genetics Srl;BETTER VALUE HEALTHCARE LTD;ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM;European Public Health Association;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA";"HU;NL;ES;IT;UK"; 194544;648615;VIBRA;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Very fast Imaging by Broadband coherent RAman;1/06/2015;31/05/2020;;"The VIBRA project aims at developing an innovative microscope for real-time non-invasive imaging of cells and tissues, which promises to have a revolutionary impact on several fields of biology and medicine. Chemically specific vibrational signatures of molecules enable their direct structural characterization. Reliable and quantitative endogenous bio-markers can be established, e.g., to follow cell differentiation and to identify crucial properties of tissues (malignant vs benign phenotype of a tumour). In this way neoplasms can be located and their borders with normal tissue traced for surgery.

Spontaneous Raman spectroscopy demonstrated this capability, but it is intrinsically too slow for imaging. Coherent Raman microscopy, on the other hand, can reach extremely high speed (up to the video rate) but at the expense of poor chemical selectivity, being limited to a single vibrational frequency.

The ground-breaking goal of VIBRA is to combine the most detailed molecular information over the entire vibrational spectrum with the highest acquisition speed. The PI will develop a complete coherent Raman microscope for near-video-rate broadband vibrational imaging. This high risk/high gain goal will be achieved by the combination of four key developments: improved pulsed laser source; optimized non-linear interaction, enhancing the signal; increase in acquisition speed, thanks to innovative spectrometers; parallel on-board data processing.

In the final application phase, the VIBRA project will validate the performances of the novel vibrational imaging system studying two important bio-medical problems: cancerous cell differentiation and detection of neuronal tumours. This will pave the way towards future virtual histopathology: intraoperative non-invasive evaluation of cancerous tissue. My vision is to allow researchers and doctors without a specific knowledge in lasers and optics to routinely visualize functional properties of cells and tissues in vivo.";1822500;1822500;ERC-2014-CoG;ERC-COG;POLITECNICO DI MILANO;IT;;; 194640;650006;PROFIT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Cost-effective high speed Production for Fasteners in Titanium for the automotive industry;1/10/2014;31/01/2015;;"Starting originally in 1950 with the manufacturing of titanium components for motorsports, we, POGGIPOLINI became official suppliers for the Formula One (Ferrari and McLaren) in the 80s, the aerospace industry in the 90s (Augusta helicopters) and finally the automotive industry in 2004 (Ferrari, Lamborghini, Bugatti, McLaren and Porsche). Following a change in F1 regulations in 2009 limiting our production, we decided to reorient our strategy towards the aerospace and automotive industries. Today, we have become a recognized specialist in technical weight reduction solutions, critical components and structural fastening systems. With over 60 years of experience with titanium, aluminium, special alloys and composite, our full service capabilities range from engineering, R&D to system integration and final turnkey packaging using the most technological equipment and processes available. Currently, aerospace represent 54% of our business (total turnover > 8 million). Regarding automotive, thanks to the close relationship between the industries of motorsport and automotive, we have been able to develop a robust customer base for high end products and limited series. Nonetheless, this segment occupies only 21% of our total business.
With the ProFiT project and its revolutionary manufacturing process for titanium bolts, POGGIPOLINI will move from a semi-manual production (200,000 units / 13.5 production cost) towards a mass production process (potential up to 30 million / < 5 production cost): the subsequent price reduction (> 60%) of the titanium bolts will allow us to expand our automotive market to general cars and by doing so triple our turnover by 2020.";71429;50000;H2020-SMEINST-1-2014;SME-1;POGGIPOLINI SRL;IT;;; 194768;652132;eyePoC;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of a new diagnostic and monitoring PoC medical device based on quantification of biomarkers in tear fluids to improve the quality of eye health care;1/10/2014;31/03/2015;;"Ocular diseases are not only relevant social, sanitary and economic issues, but also a growing market opportunity in an increasingly ageing population. Ophthalmology is a health care area where the availability of easy to use point of care (PoC) medical devices based on biomarkers is fundamental for improving patient vision care, reducing number and frequency of sick leave and disability due to visual problems and for getting a significant reduction of overcrowding of ophthalmology units at health systems. The use of medical devices able to detect and measure biomarkers in human samples in a fast and non-invasive method will allow the easy introduction of these systems at the doctors office, thus enabling diagnosis of diseases in an objective manner and accurately monitoring of treatments effectiveness to be introduced into the standard clinical protocols.
The present project is aimed to the clinical validation and market introduction of a device previously developed for ocular surface diseases (OSDs), named Tear Monitor and focused on diagnosis and monitoring of the Dry Eye and inflammation by measuring biomarkers in tears. For this purpose, two European SMEs specialised on ophthalmology establish a collaborative partnership to joint their respective expertises in a complementary synergism to reach the objectives proposed. Horus Pharma, a French pharmaceutical company, specialised on production, distribution and sales of pharmaceutical and biotech products for eye therapy and diagnostic; and Bioftalmik, a Spanish company specialised on biomarker discovery and development of medical devices for ophthalmology applications.
This project is crucial for the economic growth and international expansion of both companies and constitutes the base for strategic development in the immediate future.";71429;50000;H2020-SMEINST-1-2014;SME-1;HORUS PHARMA SAS;FR;BIOFTALMIK S.L.;ES; 194450;646517;DemoWind;SIGNED;H2020-EU.3.3.2.;LCE-18-2014;H2020;DemoWind ERA-NET Cofund action - delivering cost reduction in offshore wind;1/01/2015;31/12/2019;;"DemoWind proposes to launch and implement a coordinated, collaborative, joint offshore wind technology demonstration Call worth in excess of 100m between 2015-19 under Horizon 2020 topic LCE 18 2014: Supporting Joint Actions on demonstration and validation of innovative energy solutions.

Partners: Belgium, Denmark, the Netherlands, Portugal, Spain, and the United Kingdom, aim to pool their national resources of up to M21.2, matched with M10.4 of funding from the EC.

DemoWind is focussed on enabling industry, through partnership, to push technologies through TRLs 5-6 to 6-7 in transnationally funded projects. We aim to connect existing and new European offshore wind demonstration opportunities, exchange knowledge and facilitate the acceleration of cost reducing innovative technologies to commercialisation.
This action will contribute to European cost reduction targets for offshore wind, economic development of the European offshore wind sector and help to maintain the EUs internationally leading position in offshore wind. Reducing the technology cost is essential to increase the deployment of offshore wind making a significant contribution to the EUs climate change targets, replacing aging fossil burning power plant with affordable wind energy.

DemoWind has 5 work packages which will be overseen by a Management Group, and coordinated by the UK Department of Energy and Climate Change. A Project Secretariat will support implementation and an Advisory Board will ensure that actions remain relevant to the needs of the offshore wind industry. Other work packages include:
Preparation and launch of the transnational Call for proposals;
Proposal assessment and selection;
Monitoring of projects and evaluation of the overall programme and individual projects;
Communication, dissemination and exploitation to ensure that funded transnational projects deliver impact.";23585334;7783160,22;H2020-LCE-2014-3;ERA-NET-Cofund;The Department Of Energy and Climate Change;UK;"MINISTERIE VAN ECONOMISCHE ZAKEN;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;ENERGISTYRELSEN;AGENTSCHAP VOOR INNOVATIE DOOR WETENSCHAP EN TECHNOLOGIE;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"NL;ES;DK;BE;PT"; 194503;647473;CWASI;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Coping with water scarcity in a globalized world;1/07/2015;30/06/2020;;"We intend to set up a new globalized perspective to tackle water and food security in the 21st century. This issue is intrinsically global as the international trade of massive amounts of food makes societies less reliant on locally available water, and entails large-scale transfers of virtual water (defined as the water needed to produce a given amount of a food commodity). The network of virtual water trade connects a large portion of the global population, with 2800 km3 of virtual water moved around the globe in a year. We provide here definitive indications on the effects of the globalization of (virtual) water on the vulnerability to a water crisis of the global water system. More specifically, we formulate the following research hypotheses:
1) The globalization of (virtual) water resources is a short-term solution to malnourishment, famine, and conflicts, but it also has relevant negative implications for human societies.
2) The virtual water dynamics provide the suitable framework in order to quantitatively relate water-crises occurrence to environmental and socio-economic factors.
3) The risk of catastrophic, global-scale, water crises will increase in the next decades.
To test these hypotheses, we will capitalize on the tremendous amount of information embedded in nearly 50 years of available food and virtual water trade data. We will adopt an innovative research approach based on the use of: advanced statistical tools for data verification and uncertainty modeling; methods borrowed from the complex network theory, aimed at analyzing the propagation of failures through the network; multivariate nonlinear analyses, to reproduce the dependence of virtual water on time and on external drivers; multi-state stochastic modeling, to study the effect on the global water system of random fluctuations of the external drivers; and scenario analysis, to predict the future probability of occurrence of water crises.";1222500;1222500;ERC-2014-CoG;ERC-COG;POLITECNICO DI TORINO;IT;;; 194549;648785;BODY-UI;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Using Embodied Cognition to Create the Next Generations of Body-based User Interfaces;1/05/2015;30/04/2020;;"Recent advances in user interfaces (UIs) allow users to interact with computers using only their body, so-called body-based UIs. Instead of moving a mouse or tapping a touch surface, people can use whole-body movements to navigate in games, gesture in mid-air to interact with large displays, or scratch their forearm to control a mobile phone. Body-based UIs are attractive because they free users from having to hold or touch a device and because they allow always-on, eyes-free interaction. Currently, however, research on body-based UIs proceeds in an ad hoc fashion and when body-based UIs are compared to device-based alternatives, they perform poorly. This is likely because little is known about the body as a user interface and because it is unclear whether theory and design principles from human-computer interaction (HCI) can be applied to body-based UIs. While body-based UIs may well be the next interaction paradigm for HCI, results so far are mixed.

This project aims at establishing the scientific foundation for the next generations of body-based UIs. The main novelty in my approach is to use results and methods from research on embodied cognition. Embodied cognition suggest that thinking (including reasoning, memory, and emotion) is shaped by our bodies, and conversely, that our bodies reflect thinking. We use embodied cognition to study how body-based UIs affect users, and to increase our understanding of similarities and differences to device-based input. From those studies we develop new body-based UIs, both for input (e.g., gestures in mid-air) and output (e.g., stimulating users muscles to move their fingers), and evaluate users experience of interacting through their bodies. We also show how models, evaluation criteria, and design principles in HCI need to be adapted for embodied cognition and body-based UIs. If successful, the project will show how to create body-based UIs that are usable and orders of magnitude better than current UIs.";1853158;1853158;ERC-2014-CoG;ERC-COG;KOBENHAVNS UNIVERSITET;DK;;; 194439;646433;NAIADES;SIGNED;H2020-EU.3.3.;LCE-10-2014;H2020;Na-Ion bAttery Demonstration for Electric Storage;1/01/2015;31/12/2018;;"Wide scale implementation of renewable energy will require growth in production of inexpensive, efficient energy storage systems. The extension of battery technology to large-scale storage will become necessary as intermittent renewable energy sources such as wind, solar and wave become more prevalent and integrated into electrical grid. Lithium-ion battery appears as quite mature for this application but its cost per mWh remains high in comparison to high temperature technology such as Zebra, which integrate low cost sodium base materials. Furthermore, as the use of large format lithium battery becomes widespread; increase demand for lithium commodity chemicals combined with geographically constrained Li mineral reserves will drive up prices. Based on the wide availability and low cost of sodium, ambient temperature sodium-based batteries have the potential for meeting large scale grid energy storage needs. In NAIADES we will demonstrate the feasibility of ambient temperature Na-ion battery from the knowledge and achievement that has been done at the laboratory scale, up to a module demonstration in a realistic application environment.
Several European industrials, institutes and universities belonging to ALISTORE-ERI have decided to join their efforts to assess the Na-ion technology for stationary storage application through building a 1 kW modules system Na-ion cell which will serve as data base to demonstrate economical and public acceptance.
These module prototypes will be developed to meet performances in a 1kW system in a cost-effective, sustainable and environmental-friendly manner. New energy policy will be developed to integer the Na-ion battery in the Smart Grid initiative and promote the penetration of renewable energy in the electric network.";6492262,5;6492262;H2020-LCE-2014-3;RIA;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FR;"RHODIA OPERATIONS;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;VDE PRUF- UND ZERTIFIZIERUNGSINSTITUT GMBH;MAST CARBON INTERNATIONAL LTD;CHALMERS TEKNISKA HOEGSKOLA AB;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;ESTABANELL Y PAHISA ENERGIA SA;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.;SAFT";"FR;ES;DE;UK;SE;BE"; 194419;646155;INSPIRED;SIGNED;H2020-EU.2.1.2.1.;NMP-05-2014;H2020;INdustrial Scale Production of Innovative nanomateRials for printEd Devices;1/01/2015;31/12/2018;;"Printed electronics (PE) is set to revolutionise the electronics industry over the next decade and can offer Europe the opportunity to regain lost market share. Printed electronics allows for the direct printing of a range of functional (conductive, resistive, capacitive and semi-conducting) nanomaterials formulations to enable a simpler, more cost-effective, high performance and high volume processing in comparison to traditional printed circuit board and semiconductor manufacturing techniques. It has been reported by Frost and Sullivan that the market for printed electronics will increase in revenues from $0.53Bn in 2010 to $5.04 Bn in 2016 at a compound annual growth rate of 32.5%.
However, the migration towards low-cost, liquid-based, high resolution deposition and patterning using high throughput techniques, such as inkjet printing, requires that suitable functional nanomaterials formulations (e.g. inks) are available for end users in industrially relevant quantities. Presently, there are issues with industrial supply of nanomaterials which are low cost, high performance, environmentally friendly and tailored for high throughput systems. Therefore better collaboration is warranted between supply chain partners to ensure nanomaterial production and nanomaterial formulations are tailored for end use applications to meet this need.
The INSPIRED project will address these fundamental issues within the printed electronics industry: Ensuring that suitable functional nanomaterials formulations (inks) are available for end users in industrial scale quantities. Production of these nanomaterial formulations on an industrial scale and then depositing them using cost-effective, high throughput printing technologies enables rapid production of printed electronic components, on a wide variety of substrates. Therefore, enabling new electronics applications, whilst overcoming the problems associated with traditional manufacturing.";8005838,79;6414871,8;H2020-NMP-PILOTS-2014;IA;JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH;AT;"NANOTECCENTER WEIZ FORSCHUNGSGESELLSCHAFT MBH;FUNDACION TECNALIA RESEARCH & INNOVATION;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;NANOTECHNOLOGY INDUSTRIES ASSOCIATION;NEXCIS;THOMAS SWAN & CO LIMITED;INTRINSIQ MATERIALS LIMITED;UNIVERSIDAD DE SANTIAGO DE COMPOSTELA;EUROLCDS SIA;BIONANONET FORSCHUNGSGESELLSCHAFT MBH;NANOGAP SUB-NM-POWDER SA;TOUCHNETIX LIMITED;M-SOLV LTD";"AT;ES;IT;BE;FR;UK;LV"; 194795;652491;OILMOD;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Optical Injection Locked Modulator;1/11/2014;30/04/2015;;"Video, mobile and cloud have driven network bandwidth to grow at astonishing rates, estimated at about 40% growth year over year. Between 2000 and 2009 channel data rates in commercial optical fibre networks were peaking at 10Gb/s. Introduction of coherent technology caused a step change and around 2011 rates jumped to 100Gb/s for long haul transmission. It was enabled by advances in digital signal processing, narrow linewidth lasers, coherent receivers and optical modulators. Such modulators are used to control both the level and phase of the optical signal to send data and are the main topic of this proposal.
State of the art modulators are based on a common optical transmitter circuit (a Mach-Zehnder Modulator) to encode the data. In 2012 researchers at the Univ. Southampton invented a new device and applied for a patent on the concept. It is based on optical injection locking (OIL) and allows directly modulated lasers to be used to encode the data. Demonstration systems were developed in partnership with Eblana Photonics who provided the OIL laser devices and is the exclusive licensee to the patent IP. Eblana, established in Dublin in 2001, provides laser sources for sensing and high volume comms applications.
The technique has received strong interest from the scientific community and, significantly, network system manufacturers who have stated eagerness to trial prototypes.
Differentiators are that the output is linear, drive electronics are fundamentally simpler and uses half the number of high speed connections compared to the competition. Key advantages include low cost, low power consumption and amenable to miniaturisation to very small sizes.
Coherent 100G transmission will migrate to shorter reach and wider usage in metropolitan networks (60-800km range) and in enterprise and access at shorter distances and these are the market focus. Eblana Photonics will exploit this technology to become the highest volume supplier of such modulators in the world.";71429;50000;H2020-SMEINST-1-2014;SME-1;EBLANA PHOTONICS LIMITED;IE;;; 194487;647107;SEMICOMPLEX;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Divide and conquer ab initio semiclassical molecular dynamics for spectroscopic calculations of complex systems;1/11/2015;31/10/2020;;"Given the continuing revolution in nano and bio technologies, it is urgent for chemists to be able to carry out reliable quantum dynamics simulations of complex molecular systems. The goal of this project is to fill the gap between theory and experiment and provide the community with a user-friendly computational tool for nuclear spectra (IR, vibro-electronic, etc.) calculations of very complex systems.
Present theoretical methodologies are hampered either by artificial nuclear potential interactions or by local potential perturbation assumptions. The semiclassical molecular dynamics method that I have been pioneering is not affected by these limitations because it is based on ab initio classical trajectories. The nuclear forces can be calculated by any electronic structure software and trajectories can explore the entire potential surface. The remaining challenge is to overcome the exponential scaling of computational power.
I will adopt a divide-and-conquer strategy to beat the curse of dimensionality. Firstly, the ab initio classical molecular dynamics is performed for the entire complex system. Then, partial spectra are calculated by using the semiclassical information derived by the projection of the trajectories onto lower dimensional spaces. Vibrational modes are not artificially decoupled. Finally, the entire spectrum is reconstructed piece by piece. This method allows chemists to have a more reliable spectral interpretation in a wider context up to the nanoscale. With the help of my own previous experience and my collaborations, I will simulate pollutant photodegradation for environmental remediation and the vibro-electronic spectra of carcinogenic molecules adsorbed on TiO2. I will also reproduce the spectroscopic properties of molecular nano-texturing of titania films for outdoor cultural heritage preservation.
A new generation of semiclassical fellows will be educated to put Europe on the leading edge of quantum simulations for spectroscopy.";1899973;1899973;ERC-2014-CoG;ERC-COG;UNIVERSITA DEGLI STUDI DI MILANO;IT;;; 194529;648235;MITOsmORFs;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Identification and analysis of novel mitochondrial proteins encoded by small open reading frames;1/09/2015;31/08/2020;;Mitochondria are essential organelles with crucial roles in cellular energy metabolism, Fe-S cluster biogenesis, signaling and apoptosis. Mitochondrial dysfunction causes encephalomyopathy and neurodegenerative diseases. Mitochondria possess a remarkably high content of small proteins compared to other cellular compartments. About one third of the cellular proteins 15 kDa characterized to date are located in mitochondria. Functional examples of such small proteins cover the whole mitochondrial biology like cristae morphology, Fe-S cluster formation, metabolite transport, protein biogenesis and respiration. However, the intracellular localization and function of most small proteins is unknown. These small proteins constitute one third of the uncharacterized open reading frames and even three quarters of the dubious open reading frames in the model organism budding yeast. Taken together we predict that more than 10% of the mitochondrial proteome deserves to be discovered. In an initial study we demonstrated the mitochondrial localization of several uncharacterized small open reading frame (smORF) proteins. MITOsmORFs aims to identify over 100 novel small mitochondrial proteins. MITOsmORFs will determine the submitochondrial localization and the functional role of the novel mitochondrial proteins by genetic, proteomic, metabolomic and lipidomic analysis, including interaction mapping and characterization of mitochondrial activities in vivo and in organello to explore the unknown biology of smORF proteins localized to mitochondria.;2000000;2000000;ERC-2014-CoG;ERC-COG;UNIVERSITAETSKLINIKUM FREIBURG;DE;ALBERT-LUDWIGS-UNIVERSITAET FREIBURG;DE; 194753;651823;POLARIS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.7.";DRS-17-2014-1;H2020;Preventative OperationaL procedures for space weAtheR threats to CrItical InfraStructure;1/12/2014;31/05/2015;;"Protection of critical infrastructure in particular in the areas of energy/transport and communication grids is now crucial within our highly technical dependent societies. The scope for this project is to focus on the development of a commercial service offering to operators of such critical infrastructure which provides preventative operational procedures tailored to their individual needs. The operational procedures are based upon threat assessments received from external sources and in this proposal we are focusing on the initial threat detection which shall be incorporated into the service which is based upon Space Weather analysis.

Space weather can have detrimental, and in some cases catastrophic, effects upon critical infrastructure on which we depend as part our daily lives. Adverse space weather has dramatically different effects on these the services provided by such critical infrastructure based on the underlying technologies in use and there location.

For example a power transmission network operator in high latitudes and a traffic flow monitor network operator is low latitudes have completely different preventative operational procedures and space weather concerns. An operator therefore needs to understand the impact for their facility on a threat, an expert analysis and interpretation on a received threat and be informed in terms the operator understands on the steps required to prevent the threat escalating to become a major issue.

Currently only global forecasts and information on the type of space weather events are available, missing the vital links between space weather and the operational procedures to mitigate the threat for a particular operator.

We therefore propose to develop a system and a service offering titled, POLARIS, that will provide a single point of contact for the alerting alerting of threats, expert analysis and the issuing of operational procedures tailored to the needs of a particular urban critical infrastructure.";71429;50000;H2020-SMEINST-1-2014;SME-1;SKYTEK LTD;IE;;; 194627;649860;GreenS;SIGNED;H2020-EU.3.3.7.;EE-08-2014;H2020;GreenS Green public procurement supporters for innovative and sustainable institutional change;1/06/2015;31/05/2018;;"The main goal is to strengthen capacity of public authorities to successfully apply GPP with priority, enhancing their ability and capacity to save energy, reduce CO2 emissions and costs by applying innovative solutions on GPP. By the establishment of supporting permanent structures, called G.PP.S. Green Public Procurement Supporters (Supporting Units) within the participating Energy Agencies, the project implementation provides long-term support and technical assistance on GPP to the public authorities, and multi-level cooperation among different actors at national, regional and local level on GPP. The project objectives are to address the obstacles to the uptake of GPP that have been identified by the partners in their own country (context analysis) and which come from the WP2 Institutional needs on GPP and Good and bad practices analysis in each participating country. The implementation of pilot projects, by aiming to intensively consult public administrations in the implementation of pilot green procurement process, have the scope to test on the field that are the most efficient and effective actions to provide GPP implementation and up-take. More concretely, the project aims at achieving the specific objectives, by implementing the following actions:
analysing in each participating country the existing bad and good practices on GPP;
analyzing the SEAPs in each participant country. By the SEAPs analysis, the consortium will find where local authorities need support for Green products and services (energy related);
establishing so-called G.PP.S. in Energy Agencies in 7 EU participating countries;
giving support on GPP instruments and tools;
setting up and supporting sustainable training programmes (including how to finance them) and finding long-term solutions by the institutionalisation of GPP training;
testing GPP application and innovation;
at least 21 PA will be invited to experiment the technical support by the G.PP.S.";1489540,33;1489540,33;H2020-EE-2014-3-MarketUptake;CSA;AGENZIA LOCALE PER L'ENERGIA E LO SVILUPPO SOSTENIBILE DELLA PROVINCIA DI COSENZA SRL;IT;"FEDERACION ANDALUZA DE MUNICIPIOS Y PROVINCIAS;ENERGIKONTOR NORR AB;NATIONAL ASSOCIATION OF MUNICIPALITIES IN THE REPUBLIC OF BULGARIA;LOKALNA ENERGETSKA AGENCIJA ZA POMURJE ZAVOD ZA PROMOCIJO IN POSPEVANJE TRAJNOSTNEGA ENERGETSKEGA RAZVOJA MARTJANCI;CHERNOMORSKA REGIONALNA AGENZIA ZA UPRAVLENIE NA ENERGIYATA;RIGAS PLANOSANAS REGIONS;CALABRIA REGIONE;SKUPNOST OBCIN SLOVENIJE;ICLEI EUROPEAN SECRETARIAT GMBH (ICLEI EUROPASEKRETARIAT GMBH)*;FUNDACION MEDIO AMBIENTE, ENERGIA Y SOSTENIBILIDAD PROVINCIA DE CADIZ;ENERGEIAKO GRAFEIO KYPRION POLITON (CYPRUS ENERGY AGENCY);RIGAS DOME;MINISTRY OF AGRICULTURE, RURAL DEVELOPMENT AND ENVIRONMENT OF CYPRUS";"ES;SE;BG;SI;LV;IT;DE;CY"; 194446;646476;EMPOWER;SIGNED;H2020-EU.3.3.4.;LCE-07-2014;H2020;Local Electricity retail Markets for Prosumer smart grid pOWER services;1/01/2015;31/12/2017;;"The aim is to explore and develop an integrated ICT solution to support the development of an electricity local market place and innovative business models, including operational methods to encourage micro-generation with renewable resources and participation of consumers and prosumers. The creation of incentives for all players would allow for exploiting the latent flexibility of the user-side of the electricity distribution net. This would greatly enhance the benefits of distributed renewable resources and enhance the impact and sustainability of demand-response programs. A local electricity market approach supported by innovative ICT platforms can operate effectively in a synchronized way with the overall energy system and market. The solution will create a shared engagement of local supply alleviating the traditional DSOs need to invest in centralized sourcing.
The proposals integrated ICT real-time platform would be able to manage trading, metering and management of electricity flow according to the transactions completed within the local market and beyond its boundaries. EMPOWER follows a micro-grid approach where energy flow is controlled by devices that are managed by a cloud-based management module. The management module also supports the trading that is handled by customizable software agents. Aggregation of contributions from the user community, metering, credit assignments, predictions and strategy maintenance would be aligned to different business models. A real-time communication module links the management part with the micro-grid control and household devices assigned to an integrated demand-response regime.
EMPOWER will be tested at three representative locations across Europe, to prove that a ICT-supported local market approach would be accepted by consumers and prosumers, ensuring the required engagement and benefits to establish a highly efficient self-adaptive market solution able to balance supply and demand effectively at local level.";6120486,25;4429808,12;H2020-LCE-2014-3;IA;Schneider Electric Norge AS;NO;"FREDRIKSTAD ENERGI NETT AS;UNIVERSITAET ST. GALLEN;SMART INNOVATION NORWAY AS;ESMART SYSTEMS AS;UNIVERSITAT POLITECNICA DE CATALUNYA;MALTA INTELLIGENT ENERGY MANAGEMENT AGENCY;NEWEN PROJECTS GMBH";"NO;CH;ES;MT;DE"; 194471;646809;DIMR;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Data Intensive Modelling of the Rhizosphere Processes;1/09/2015;31/08/2020;;"We rely on soil to support the crops on which we depend. Less obviously we also rely on soil for a host of 'free services' from which we benefit. For example, soil buffers the hydrological system greatly reducing the risk of flooding after heavy rain; soil contains very large quantities of carbon, which would otherwise be released into the atmosphere where it would contribute to climate change. Given its importance it is not surprising that soil, especially its interaction with plant roots, has been a focus of many researchers. However the complex and opaque nature of soil has always made it a difficult medium to study.
In this ERC research program I will develop a state of the art image based model of the physical and chemical properties of soil and soil-root interactions, i.e., a quantitative, model of the rhizosphere based on fundamental scientific laws.
This will be realised by a combination of innovative, data rich fusion of structural and chemical imaging methods, integration of experimental efforts to both support and challenge modelling capabilities at the scale of underpinning bio-physical processes, and application of mathematically sound homogenisation/scale-up techniques to translate knowledge from rhizosphere to field scale. The specific science questions I will address with these techniques are: (1) how does the soil around the root, the rhizosphere, function and influence the soil ecosystems at multiple scales, (2) what is the role of root-soil interface micro morphology and mycorrhizae on plant nutrient uptake, (3) what is the effect of plant exuded mucilage on the soil morphology, mechanics and resulting field and ecosystem scale soil function and (4) how to translate this knowledge from the single root scale to root system, field and ecosystem scale in order to predict how the climate change, different soil management strategies and plant breeding will influence the soil fertility.";1996246;1996246;ERC-2014-CoG;ERC-COG;UNIVERSITY OF SOUTHAMPTON;UK;;; 194625;649846;FosterREG;SIGNED;H2020-EU.3.3.7.;EE-07-2014;H2020;Fostering public capacity to plan, finance and manage integrated urban REGeneration for sustainable energy uptake;1/06/2015;31/05/2017;;"The lack of proper coordination of aspects related to regulation, financing and management of energy efficiency measures within urban regeneration initiatives, as well as the frequent misalignment of public stakeholders at different levels, are hindering the potential benefits of addressing these processes from an integrated perspective.

FosterREG aims at enhancing public capacity at local, regional and national levels to plan, finance and manage integrated urban regeneration for sustainable energy uptake, through capacity building, promotion and articulation of effective multilevel coordination, and national as well as European network strengthening. These objectives will be achieved through public stakeholders engagement in joint analysis and knowledge development activities, as well as creation and dissemination of targeted training materials and activities across Europe.

FosterREG relates to the Work Programme objectives by:

1) Focusing on the integration of energy efficiency measures within urban regeneration plans, with especial emphasis on building retrofitting while promoting synergies with other sectors such as transport and land-use planning.
2) Enhancing multilevel coordination (European, national, regional and local) of public authorities in the reduction of EU energy consumption.
3) Building capacity for civil servants at national, regional and local level in relation with policy design, planning, financing and management of energy efficiency measures within urban regeneration plans.
4) Fostering the implementation of the Energy Effciency Directive, in particular Articles 4 and 7.";1401921;1401921;H2020-EE-2014-3-MarketUptake;CSA;FUNDACION TECNALIA RESEARCH & INNOVATION;ES;"NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;GEMEENTE UTRECHT;Vivienda y Suelo de Euskadi, S.A.;MEDUNARODNI CENTAR ZA ODRZIVI RAZVOJ ENERGETIKE VODA I OKOLISA;GRAD OSIJEK;BILBOKO BERREGOKIPENERAKO HIRIGINTZA ELKARTEA SA - SURBISA;ENTE VASCO DE LA ENERGIA;AGENCIJA ZA PRAVNI PROMET I POSREDOVANJE NEKRETNINAMA;ASM CENTRUM BADANI I ANALIZ RYNKU SP ZOO";"NL;ES;HR;PL"; 194488;647158;FlexNets;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Quantifying Flexibility in Communication Networks;1/09/2015;31/08/2020;;Communication networks have emerged to become the basic infrastructure for all areas of our society with application areas ranging from social media to industrial production and healthcare. New requirements include the need for dynamic changes of the required resources, for example, to react to social events or to shifts of demands. Existing networks and, in particular, the Internet cannot meet those requirements mainly due to their ossification and hence limitation in resource allocation, i.e., lack of flexibility to adapt the available resources to changes of demands on a small time-scale and in an efficient way. In recent years, several concepts have emerged in networking research to provide more flexibility in networks through virtualization and control plane programmability. In particular, the split between data plane and a centralized control plane as defined by Software Defined Networking (SDN) is regarded as the basic concept to allow flexibility in networks. However, a deeper understanding of what flexibility means remains open. In this project, flexibility focuses on the dynamic changes in time and size of a network that is characterized by its resources (link rate and node capacities) and connectivity (network graph). It is the objective of this research to analyse the fundamental design space for flexibility in SDN-based networks with respect to cost such as resource usage, traffic overhead and delay. The outcome will be a set of quantitative arguments pro and contra certain design choices. An analytical cost model to quantitatively assess the trade-off for flexibility vs. cost will be developed. To assess flexibility with respect to general graph properties a graph model will be designed. The detailed analysis is based on three use cases: dynamic resource allocation, QoS control, and resilience. In the state of the art, selected aspects of flexibility have been explored for certain network scenarios, a fundamental and comprehensive analysis is missing.;1931250;1931250;ERC-2014-CoG;ERC-COG;TECHNISCHE UNIVERSITAET MUENCHEN;DE;;; 194534;648381;FNPMLS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Fundamental nuclear properties measured with laser spectroscopy;1/04/2015;31/03/2020;;The prime research theme of this project is the study of short-lived exotic nuclei with laser spectroscopy. Over the next 5 years my team will study the role of three-nucleon forces and their associated influence on nuclear structure and the limits of nuclear existence. This work will investigate the interplay between tensor and central forces and the associated effect on quantum shells in exotic nuclear systems. This proposal will study how the shape of the nucleus is modified at the limits of nuclear existence. We will use innovative laser spectroscopy methods to achieve these goals. The project will be carried out at the ISOLDE facility, CERN, which is the premier radioactive beam facility at the precision frontier. The proposed research activity closely matches the NuPECC (Nuclear Physics European Collaboration Committee) 2010 Long Range Plan. The wider scientific impact of this research will influence modelling explosive stellar processes and nuclear synthesis, understanding the structure of astrophysical compact-objects such as neutron stars and predicting regions of enhanced stability in the super heavy elements. The FNPMLS project will develop ultra-sensitive methodologies that set a new paradigm in laser spectroscopy. It builds on the cutting edge technology of collinear resonance ionization spectroscopy (CRIS) that I have developed during my STFC Advanced Fellowship. The CRIS technique combines the high resolution nature of collinear laser spectroscopy with the high sensitivity of resonance ionization spectroscopy. The research programme and investment outlined in this proposal will place my team in a unique and world leading position. This work will happen in advance of the next generation of radioactive beam facility such as SPIRAL2, FAIR and FRIB and will provide the essential ingredients for future fundamental questions.;1846541,99;1846541,99;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF MANCHESTER;UK;;; 194436;646307;PLATFORM;SIGNED;H2020-EU.2.1.2.4.;NMP-01-2014;H2020;Open access pilot plants for sustainable industrial scale nanocomposites manufacturing based on buckypapers, doped veils and prepregs;1/02/2015;31/01/2018;;"Two FP7 European projects ELECTRICAL and SARISTU aim to develop methods to manufacture CNT reinforced multifunctional composites compatible with current industrial manufacturing processes. According to the results, three CNT integration strategies appear as promising methods to be driven towards an industrial scale manufacturing process: buckypapers, CNTtreated prepreg and CNT doped nonwoven veils. Although each of the technologies can act separately they can be combined synergistically in a way that a higher multifunctional level can be achieved according to the final requirements of the application.
This project aims to develop open access pilot lines for the industrial production of buckypapers, CNT treated prepreg and CNT doped non-woven veils for composite applications in sectors such as Aeronautic and Automotive. The purpose is to efficiently and economically manufacture components using novel developed at a scale suitable for industrial uptake. The developed facilities will not only provide increased capabilities to the operating company but also offer a network of nanorelated manufacturing facilities suited to the needs of related SMEs. A European platform of nanobased pilot lines will be created to which companies, and more precisely SMEs, can gain access and make use of the facilities as well as the experience and knowledge of the operating RTO.The partners will work with existing EU clusters and initiatives aimed at the establishment of an EU nanosafety and regulatory strategy framework to ensure the safe use of these products particularly at an industrial scale. This will be achieved through collaboration with end users to ensure the developed products are accepted within existing health and safety procedures or through the introduction of new ones.PLATFORM proposes solutions that will generate new market opportunities for European Aeronautic and Automotive components manufacturing offering to OEMs new added-value products based on nano-enabled products";7797727,5;7797727,5;H2020-NMP-PILOTS-2014;RIA;FUNDACION TECNALIA RESEARCH & INNOVATION;ES;"CARBURES EUROPE SA;CENTRO RICERCHE FIAT SCPA;ADAMANT AERODIASTIMIKES EFARMOGES ETAIREIA PERIORISMENIS EFTHYNIS;SISTEPLANT SL;ELEMENT MATERIALS TECHNOLOGY HITCHIN LIMITED;NANOCYL SA;DELTA TECH SPA;ASOCIACION ESPANOLA DE NORMALIZACION;FUNDACION PARA LA INVESTIGACION, DESARROLLO Y APLICACION DE MATERIALES COMPUESTOS;FUNDACJA PARTNERSTWA TECHNOLOGICZNEGO TECHNOLOGY PARTNERS;TOMASZ MARIAN KOSMIDER;PANEPISTIMIO PATRON";"ES;IT;EL;UK;BE;PL"; 194472;646807;EXMAG;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Excitonic Magnetism in Strongly Correlated Materials;1/06/2015;31/05/2020;;Spontaneous symmetry breaking leading to states of matter with long-range order is one of the central topics in condensed matter physics. Common types of order, such as ferro- and anti-ferromagnetic, are characterized by spin or charge densities modulated on inter-atomic scale, therefore well studied thanks to various scattering experiments. Order parameters that are not of this type are much more difficult to detect, giving rise to names such as hidden order or electronic nematicity. Their impact on transport or thermodynamic properties may, nevertheless, be substantial. In the EXMAG project we will investigate excitonic condensation in systems with strongly correlated electrons as a new mechanism leading to unconventional ordered states. The objective of the project is to characterize the physical properties of various excitonic phases and to find their realization in real materials. We will focus on intermediate coupling strength and doped systems where the interaction between the excitonic order and the charge carriers is expected to lead to new physics. In particular, we want to explore the potential of the excitonic order to induce instabilities, e.g. magnetic or superconducting, that are not present in the normal phase. We will also address the possibility of topologically non-trivial quasi-particle band-structures in the excitonic phase. Our main tool will be numerical simulations based on the dynamical mean-field theory and ab initio band-structure methods. We will pursue two main lines of research: investigation of simple models allowing access to many physical observables and studies of real materials capturing the chemical complexities at the cost of more severe approximations. Ultimately, we want to understand in detail the properties of the excitonic magnets and their potential functionalities,and to identify the main control parameters and promising materials.;1382500;1382500;ERC-2014-CoG;ERC-COG;TECHNISCHE UNIVERSITAET WIEN;AT;FYZIKALNI USTAV AV CR V.V.I;CZ; 194778;652365;Insuwaste;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;Recycling of hard-to-treat, post-consumer textile wastes and conversion to insulation material for construction industry using a novel conversion technology.;1/11/2014;30/04/2015;;"This project, is relevent to call topic SC5-20-2014-1, is designed to scale up, develop and commercialise a manufacturing process for converting currently unusable post-consumer contaminated fibre waste from carpets and mattresses to a value added thermal and/or acoustic insulation for use in the building & construction industry. The project develops a novel insulation panel or roll with the effective design and development of a manufacturing system to collect and reprocess with novel anti-bacterial treatments to produce a competitive product that can be systemised at the commercial scale.

A successful proof of principle trial and sample material has been produced. A detailed techno-economic feasibility study and experimental work is required for the improvement of the thermal performance and neutralisation of the bacterial contamination in the recycled fibre waste from carpets and mattresses. In addition, the production line requires machinery for cutting, tearing, cleaning, anti-bacterial contamination processing and packaging at the manufacturing level. EC support is the catalyst needed to drive this innovation into the market, while the exposure the scheme brings will help us to penetrate the market more quickly and exploit this technology in the UK, and will exploit within Europe and/or licence to others. The likely benefits to the partners, endusers and society are the access to valuable textile fibre, a significant reduction of carbon emissions and fostering business models that bring fibre waste close to zero and build a better understanding of the environmental impact of carpet waste fibre, as well as to mitigate the dependency of Europe on imported raw textiles.";71429;50000;H2020-SMEINST-1-2014;SME-1;JAMES ROBINSON FIBRES LIMITED;UK;;; 194516;647849;RINGE3;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Structural and mechanistic insights into RING E3-mediated ubiquitination;1/05/2015;30/04/2020;;Ubiquitin (Ub) conjugation regulates a myriad of cellular processes in the eukaryotic cell. Ub-ligases (E3) play a pivotal role in deciding the substrates fate and function by catalyzing the transfer of Ub from Ub-conjugating enzyme (E2) to a substrate protein lysine sidechain. Successive rounds of E3-catalyzed substrate ubiquitination lead to the formation of poly-Ub chains or multi-monoubiquitination, which direct the substrate to different biological fates such as degradation by the 26S proteasome. RING E3s comprise the largest family of E3s with approximately 600 members in humans. Over the last fifteen years, structural biology and biochemical studies have paved the way for understanding how RING E3s interact with E2s and substrates, and how they are regulated. Recently my group has trapped the crystal structure of a RING E3 bound to an E2 covalently-linked to Ub (E2~Ub), thus providing a molecular snapshot of how RING E3 optimizes E2~Ub for catalysis. Despite these advances, the mechanisms of RING E3-catalyzed ubiquitination are not completely understood. Here, we propose to investigate three key aspects of RING E3 functions. First, we will determine structures of several RING E3s bound to E2~Ub to dissect the molecular basis for RING E3-E2~Ub selectivity. Second, our recent structure of a RING E3, Cbl-b, bound to E2~Ub and a substrate peptide provides a starting point for structural determination of a more challenging RING E3-E2~Ub-intact substrate complex to elucidate the mechanisms of substrate ubiquitination. Third, we have developed an ubiquitinated Cbl-substrate mimetic to study the mechanisms of RING E3-catalyzed poly-ubiquitination using structural and biochemical approaches. Expected results will greatly expand our knowledge of RING E3-mediated ubiquitination and will foster strategies in exploiting E3s for therapeutic development, since deregulation of E3s underlies many diseases including cancers.;2000000;2000000;ERC-2014-CoG;ERC-COG;BEATSON INSTITUTE FOR CANCER RESEARCH LBG;UK;;; 194404;645909;I-LINC;SIGNED;H2020-EU.3.6.;INSO-6-2014;H2020;Platform for ICT learning and inclusion for youth employability and entrepreneurship;1/01/2015;31/12/2017;;"'The current proposal responds to the H2020 topic 'Platform for ICT for Learning and Inclusion'. Its main objective is to establish a sustainable, overarching platform for ICT (for) learning and inclusion focused on boosting the employability and entrepreneurship of young people.
As key stakeholders in the ICT learning and e-Inclusion sector themselves, the consortium partners are called to lead such a platform and be a guarantee for its sustainability. This will bring together a broad spectrum of stakeholders (civil society organisations, educational institutions, ICT industry, policy-makers, researchers, individual experts and practitioners) and end users (youth). Three main stakeholder groups coordinated by partners, i.e. formal education and training institutions and organisations [European SchoolNet]; digital and socio-economic inclusion organisations/networks [Telecentre Europe] and organisations focused on youth employability [Telefnica], plus a selected pool of changemakers, will collaboratively design innovative and sustainable solutions by benefiting from existing platforms, networks and resources that the project will collect and link. In achievement of the overall objective of the proposed action, this project aims to:
- Develop a wide, rich and active community of stakeholders, aspiring to become a reference point in the long run in the field of ICT (for) learning and inclusion;
- Link existing stakeholder activities in the field of ICT (for) learning and inclusion and join them to increase their impact both on policy-maker and end-user level.
- Contribute to the improvement of existing platforms by creating a common (blended) space for open dialogue and meetings, and foster active mutual exchanges and peer-learning activities.
- Define directions on how to improve tools and services for the modernisation of education and training and the employability of young people while tackling the risk of digital and socio-economic exclusion (i.e. eInclusion).'";1109250;1109250;H2020-INSO-2014;CSA;TELECENTRE-EUROPE AISBL;BE;"TECHNISCHE UNIVERSITAT DORTMUND;EUN PARTNERSHIP AISBL;TELEFONICA SA";"DE;BE;ES"; 194738;651611;GO4APP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Graphene oxide for advanced polymer applications;1/10/2014;28/02/2015;;"GRAPHENEA proposes the present project in order to take the Graphene Oxide (GO) a step closer to the market through specific polymer applications. This will have a direct impact not only in the global economy, but also in the society, and at the same time will lead GRAPHENEA to become the worldwide reference as GO producer with the necessary production capacity to supply the polymer industry and the research laboratories. More specifically, the GO4APP objectives are:
To use all the competitive advantages of GO (aspect ratio, surface area, mechanical properties, functionality) as filler material in advanced polymer composites.
To produce tailor made GO materials (further functionalised) to improve compatibility with different matrices, leading to a broad range of applications.
The large-scale synthesis of GO to be able to enter/supply the advanced polymers industry.
The integration of GO into polymeric matrices in order to obtain dramatically improved mechanical, thermal and electrical properties via the favourable interactions between GO and polymers followed by in-situ processing.
To provide cost-competitive final advanced polymer composites.
The clear GO cost reduction via dramatically increasing the production scale.
Based on already obtained and validated data for GRAPHENEAs GO competitive production methodology and its application into polymeric matrices, GRAPHENEA expects to address the above listed objectives and become ready to provide answers to the expected GO demand in the different market segments. Through the Phase 1 of the SME instrument, GRAPHENEA will be able to study the feasibility of the GO to be the centre of the herein proposed innovation project, and design in a more accurate way the breakthrough innovation activities to take the tailor made GO materials into the market, guarantying a high quality large-scale manufacturing of GO-based products.";71429;50000;H2020-SMEINST-1-2014;SME-1;Graphenea S.A.;ES;;; 194361;645690;TraSaCu;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Traffic Safety Cultures and the Safe Systems Approach Towards a Cultural Change Research and Innovation Agenda for Road Safety;1/03/2015;28/02/2018;;"Traffic Safety Culture (TraSaCu) aims at developing a cultural approach in road traffic safety research and accident prevention. Traditional approaches to traffic safety shall be complemented by a cultural perspective which has emerged recently in safety research and prevention. Safety culture has been identified as an important factor of road safety as it helps understanding and explaining the typical patterns of risk perception and risk taking that prevail in different national, regional or local traffic systems as well as their relationships with numbers and forms of accidents. A weak safety culture produce higher numbers of accidents which are more severe. A strong safety culture helps reducing the number of accidents as well as mitigating their severity. It strengthens safety relevant attitudes and behaviour and it is also a condition for making road safety measures more effective.
According to a working definition of the US Department of Transportation Safety Council (US DOT), traffic safety culture is defined as the shared values, actions, and behaviours that demonstrate a commitment to safety over competing goals and demands. However, a unified concept of safety culture still does not exist. Therefore, the project will elaborate an empirically grounded and theoretically adequate concept of traffic safety culture, based on this definition by conducting a number of case studies of different traffic safety cultures across Europe. It focuses on the safety cultures that emerge under different institutional, demographic and topographical conditions and their influence on the numbers and forms of accidents.

Research focuses on the culturally mediated interaction between traffic participants and their environment in terms of the cultural patterns of risk taking and risk perception. It also looks at those cultural elements that can be changed easily in order to improve road safety of the investigated traffic systems.";499500;499500;H2020-MSCA-RISE-2014;MSCA-RISE;KURATORIUM FUER VERKEHRSSICHERHEIT;AT;"SUOMALAINEN LIIKENNETUTKIMUSKESKUS OY;""HELLENIC RESEARCH AND EDUCATIONAL INSTITUTE """"PANOS MYLANOS"""" FOR THE ROAD SAFETY AND THE PREVENTION/REDUCATION OF TRAFFIC ACCIDENTS"";TECHNISCHE UNIVERSITAET WIEN;TELECOMMUNICATION AND COMPUTER NETWORKING TNC SHPK;TALLINNA TEHNIKAULIKOOL;CO-PLAN INSTITUTI PER ZHVILLIMIN EHABIITATIT;UNIVERSITETI POLIS SHPK;STICHTING WETENSCHAPPELIJK ONDERZOEK VERKEERSVEILIGHEID;MIDDLE EAST TECHNICAL UNIVERSITY";"FI;EL;AT;AL;EE;NL;TR"; 194425;646426;STORY;SIGNED;H2020-EU.3.3.;LCE-08-2014;H2020;STORY- Added value of STORage in distribution sYstems;1/05/2015;30/04/2020;;"The main objective of STORY is to show the added value storage can bring for a flexible, secure and sustainable energy system. This will be achieved by showing the inter-relations between technologies and stakeholders as well as the potential and impact of policy and regulation.

The future European grid has to serve a diverse and mixed landscape of users in a situation of mixed rules and responsibilities depending on the policy and regulatory choices that will be made. Challenges include high penetration of renewables, bi-directional flows of different energy vectors, growing number of users and requirements for higher security. The European commission wants to strengthen the position of the EU energy industry, including those players active in producing solutions for security of supply, increased share of renewables and grid stability. The advances in ICT technology, intelligent control algorithms, inverter and storage technologies provide strong tools to cope with these challenges.
Given this context, STORY focuses on providing relevant and wide-covering demonstrations that serve as input for a thorough and transparent analysis on what the impact of storage can be for the involved stakeholders. Storage is considered as a means, while not neglecting other competing technologies that could provide a similar or complementary functionality.
The actions that the 18 members from 9 European countries in STORY consortium are going to take in a 5-year project bring a valuable contribution to turn these challenges into opportunities. They will not only develop the most viable storage and ICT solutions for the demonstration sites, but they will also analyse the impact of large penetration of the technologies through simulations, analyse the effect of policies and regulations to the business opportunities of storage related industry and communicate the findings to wider community through systematic strategies for impact creation.";15353839,26;12484339;H2020-LCE-2014-3;IA;Teknologian tutkimuskeskus VTT Oy;FI;"EXPOSICION Y CONSERVACION DE ALIMENTOS Sa;PROSPEX INSTITUTE VZW;VIESSMANN-BELGIUM;TH!NK E BVBA;ACTILITY SAS;JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH;UC LEUVEN;ELEKTRO GORENJSKA PODJETJE ZA DISTRIBUCIJO ELEKTRICNE ENERGIJE DD;VLERICK BUSINESS SCHOOL;BASEN OY;HAWKER GMBH;FUNDACION CENER-CIEMAT;BENEENS JOZEF EN ZONEN BVBA;B9 ENERGY STORAGE LTD;UNIVERZA V LJUBLJANI;LOPTA FILM GMBH;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.";"ES;BE;FR;AT;SI;FI;DE;UK"; 194432;646347;WMF2015;SIGNED;"H2020-EU.2.1.;H2020-EU.2.1.3.;H2020-EU.2.1.5.;H2020-EU.2.1.2.;H2020-EU.2.";NMP-38-2014;H2020;World Manufacturing Forum 2015;1/02/2015;31/07/2016;;"The aim of this supporting action is the planning and the organization of the World Manufacturing Forum 2015 (WMF2015) to be held in the second semester of 2015. Keeping the WMF2015 in Europe is pivotal in order to retain the European leadership in key Manufacturing enabling technologies. The aim of this specific proposal is the planning and the organization of an event that can represent the flagship initiatives for the year 2015. In order to take advantage of the previous successful experience and reputation accomplished, the event will be called World Manufacturing Forum 2015. Strategic objectives of the event are:
To be an open and independent environment where industry leaders and key policy makers from all over the world, together with all relevant stakeholder, will discuss global trends, challenges threats and objectives in Manufacturing to give authorities in policy, science and industries advice for the orientation of innovation perspectives for a global competitive and sustainable development;
To be a platform where the most recent state-of-the-art of the Manufacturing research is spread and disseminated at the same time where the most interesting trends and research needs are identified, discussed and shared among interested parties and involved communities;
To be a platform for the communication of the European Commission strategies and policies to a global audience;
To be an ambitious event to present results of the European cooperative research, to support the Horizon2020 and to discuss about international cooperation in R&D;
To create visibility and better synergies between industrial and social initiatives launched by the Commission and by the Member States in a fair interplay with the other global regions.";565500;565500;H2020-NMP-CSA-2014;CSA;FONDAZIONE POLITECNICO DI MILANO;IT;"INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;CENTRE CIM FUNDACIO PRIVADA";"PT;ES"; 194473;646849;LYMPHORG;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Organ-specific mechanisms of lymphatic vascular development and specialisation;1/05/2015;30/04/2020;;Lymphatic vasculature maintains tissue fluid homeostasis and has important emerging roles in inflammation, immunity, lipid metabolism, blood pressure regulation and cancer metastasis. Lymphatic vessels are specialised to fulfil the functional needs of different organs while diseases associated with lymphatic dysfunction frequently affect vessels of specific tissues. How functional specialisation of vessels is achieved and what underlies tissue-specific vessel failure is not understood. I hypothesise that organ-specific manifestation of lymphatic dysfunction in disease is due to vascular bed-specific differences in vessel formation. In this project my aim is to identify genes and mechanisms required for organ-specific lymphatic development. Building on our recent discovery of a previously unknown progenitor cell type that is required for lymphatic development in an organ-specific manner I set out to identify the origin and function of lymphatic endothelial progenitor cells (LEPC) during development and assess their potential for therapeutic lymphatic regeneration. Towards this aim, we will identify organ-specific origins of lymphatic vasculature using lineage tracing and determine genetic signatures of lymphatic endothelial progenitors by mRNA sequencing. Cells and tissues from normal and mutant mice that show organ-specific lymphatic defects will be analysed. To identify molecular and cellular mechanisms of LEPC derived vessel formation, we will functionally characterise LEPC signature genes using mouse models and visualise vessel development by in vivo two-photon microscopy. The function and therapeutic potential of LEPCs and LEPC derived vessels will be assessed using mouse models of tolerance, inflammation, obesity and lymphoedema. This work will provide novel insights into organ-specific mechanisms of vascular morphogenesis and identify a progenitor cell that may be expoited to restore lymphatic function in disorders associated with lymphatic vessel failure.;2368439;2368439;ERC-2014-CoG;ERC-COG;Uppsala universitet;SE;;; 194519;648001;EPAF;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Role of Epithelial Apoptotic Force in Morphogenesis;1/09/2015;31/08/2020;;"Contrary to previous beliefs, recent studies have suggested that apoptotic cells play an important dynamic role during morphogenesis. Nonetheless, the mechanisms whereby dying cells drive tissue shape modification remain elusive.
Using the Drosophila developing leg as a model system to study apoptosis-dependent epithelium folding, we have recently shown that apoptotic cells produce a pulling force through the unexpected maintenance of their adherens junctions that serves as an anchor to an apico-basal Myosin II cable. The resulting apoptotic apico-basal force leads to a non-autonomous increase in tissue tension and apical constriction of surrounding cells, leading to epithelium folding. These results reveal that, far from being passively eliminated as generally thought, dying cells are very active until the end of the apoptotic process. The objective of the present proposal is to understand how apoptotic cells influence their surroundings from the micro-environment to the macro-scale level.
Our first aim is to dissect the cellular mechanisms governing the generation of the apoptotic force and its transmission to the tissue, both apically through planar polarity and basally through the extra-cellular matrix (ECM), in parallel with the identification of the network of genes orchestrating apoptosis-dependent morphogenesis through a powerful genetic screen. Interesting preliminary results have already identified the epithelio-mesenchymal-transition gene Snail as essential for the progression of apoptosis, thus validating our approach.
Therefore, the second aim of this project is to compare Snail function in the control of adhesion and ECM dynamics and in the generation of tissue tension in both EMT and apoptosis. This original comparative study should bring novel insight into these two fundamental processes.

To perform this work, we will use elegant genetic tools combined to state-of-the-art live imaging techniques, together with robust biophysical modelling.";2311843,75;2311843,75;ERC-2014-CoG;ERC-COG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194612;649656;RentalCal;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Incentives through Transparency: European Rental Housing Framework for Profitability Calculation of Energetic Retrofitting Investments;1/03/2015;28/02/2018;;"The current level of energy efficiency investments in the rental housing sector is in danger of missing EU policy targets. RentalCal aims to develop models and tools for assessing the commercial viability of energy efficiency retrofitting in the rental housing stock. This will reduce split incentive barriers, price in green added value and show a clear road map towards a sustainable housing stock. In particular, RentalCal seeks to make the following key contributions:
1. Develop the first commercial viability assessment framework for energy efficiency refurbishments specifically for rental housing
Although rental housing represents the majority of Europes multifamily housing stock, current viability calculation methods for energy efficiency retrofits are geared towards owner occupiers and ignore some inherent characteristics of the specific national rental market such as split incentives, rental regulations, tax regimes etc. RentalCal will develop an innovative standardised methodology for assessing retrofits in the private rental housing sector.
2. Increase the transparency of investment conditions in the EU housing industry
RentalCal will provide transparent information on the viability of energy efficiency investments based on legal, technical and financial conditions in eight participating member states. The standardised framework will allow for a transparent comparison of investment conditions in the EU, help to remove investment barriers in national housing markets and stimulate cross-border investment activity.
3. Disseminate key insights into the 'Green Value' proposition to specific target groups
RentalCal will provide rental property investors with target group specific information regarding the viability of a proposed retrofit investment. This includes the valuation benefits of energy-efficient buildings as well as other indirect financial benefits. All information will be available on RentalCals web based calculation and information platform.";1996766,25;1996765,75;H2020-EE-2014-3-MarketUptake;CSA;INSTITUT WOHNEN UND UMWELT GMBH;DE;"UNIVERSIDAD DE ALICANTE;STU-K AS;TiasNimbas Business School B.V.;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;AALBORG UNIVERSITET;Narodowa Agencje Poszanowania Energii SA;DELPHIS DEVELOPPEMENT ETUDES POUR LE LOGEMENT LA PROMOTION DE L'HABITAL'INNOVATION ET LE SOCIAL ASSOCIATION;KARLSRUHER INSTITUT FUER TECHNOLOGIE;UNIVERSITAET REGENSBURG;EUROPEAN GREEN CITIES APS";"ES;CZ;NL;UK;DK;PL;FR;DE"; 194499;647351;ChronHib;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Chronologicon Hibernicum A Probabilistic Chronological Framework for Dating Early Irish Language Developments and Literature;1/09/2015;31/08/2020;;"Early Medieval Irish literature (7th10th centuries) is vast in extent and rich in genres, but owing to its mostly anonymous transmission, for most texts the precise time and circumstances of composition are unknown. Unless where texts contain historical references, the only clues for a rough chronological positioning of the texts are to be found in their linguistic peculiarities. Phonology, morphology, syntax and the lexicon of the Irish language changed considerably from Early Old Irish (7th c.) into Middle Irish (c. 10th12th centuries). However, only the relative sequence of changes is well understood; for most sound changes very few narrow dates have been proposed so far.
It is the aim of Chronologicon Hibernicum to find a common solution for both problems: through the linguistic profiling of externally dated texts (esp. annalistic writing and sources with a clear historical anchorage) and through serialising the emerging linguistic and chronological data, progress will be made in assigning dates to the linguistic changes. Groundbreakingly, this will be done by using statistical methods for the seriation of the data, and for estimating dates using Bayesian inference.
The resultant information will then be used to find new dates for hitherto undated texts. On this basis, a much tighter chronological framework for the developments of the Early Medieval Irish language will be created. In a further step it will be possible to arrive at a better chronological description of medieval Irish literature as a whole, which will have repercussions on the study of the history and cultural and intellectual environment of medieval Ireland and on its connections with the wider world.
The data collected and analysed in this project will form the database Chronologicon Hibernicum which will serve as the authoritative guideline and reference point for the linguistic dating of Irish texts. In the future, the methodology will be transferable to other languages.";1804229,62;1804229,62;ERC-2014-CoG;ERC-COG;NATIONAL UNIVERSITY OF IRELAND MAYNOOTH;IE;;; 194456;646560;Bin2Grid;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.3.1.;H2020-EU.3.3.2.";LCE-14-2014;H2020;Turning unexploited food waste into biomethane supplied through local filling stations network;1/01/2015;31/12/2017;;"The overall objective of Bin2Grid concept is to promote segregated collection of food waste as energy source, conversion to biogas, and its upgrading to biomethane and utilization in associated network of filling stations.
To that end, accent will be given to defining strategies for establishing efficient network of food and beverage waste collection methods and practices. Also, whole range of food waste producers will be taken under consideration, i.e. manufacturing entities, catering/food services, retail stores.
Since biological treatment (anaerobic digestion) is without an alternative for energy utilization of food waste and together with other raw materials creates a synergy for renewable energy production (biogas/biomethane). One of the biggest advantages of such a concept of energy production is having two issues covered at the same time: environmental protection with sustainable management of food waste and the production of renewable energy with its utilization as a biofuel.
The existing technologies which are specific for this kind of raw materials will be explored. Having in mind that chemical energy of biogas is fully used when it has been upgraded to biomethane and used as a biofuel, particular attention will be given to advanced biogas to biomethane upgrading techniques for purification and technical requirements for its usage through local filling stations as a biofuel, in public transportation sector in particular (e.g. waste management trucks).";709468,75;709468;H2020-LCE-2014-3;CSA;ZAGREBACKI HOLDING DOO;HR;"WIRTSCHAFT UND INFRASTRUKTUR GMBH & CO PLANUNGS KG;JAVNO SOOBRAKAJNO PRETPRIJATIE SKOPJE;INSTITUTO ANDALUZ DE TECNOLOGIA.;GUSSING ENERGY TECHNOLOGIES GMBH;SVEUCILISTE U ZAGREBU, FAKULTET STROJARSTVA I BRODOGRADNJE;OBSERVATOIRE REGIONAL DES DECHETS D'ILE DE FRANCE;CITY OF SKOPJE";"DE;MK;ES;AT;HR;FR"; 194763;652017;BIOFERLUDAN;SIGNED;"H2020-EU.3.5.;H2020-EU.2.3.1.";SC5-20-2014-1;H2020;BIOFERLUDAN: COST-EFFECTIVE HUMIC FERTILIZERS TROUGH DIGESTATE TREATMENT AT INDUSTRIAL BIOGAS PLANT;1/10/2014;31/03/2015;;"Ludan Renewable Energy S.L. (LRE) is an engineering company with extensive experience in the business of biogas and treatment of bio-wastes. LRE main product is biogas compact plant, focus to small/medium energy projects (250-400 kW) where self-supply and waste management are the main targets. With BIOFERLUDAN project, LRE wants to take a step beyond responding new demands of cost-effective and reliable treatment for the digestate, the main by-product of these installations, developing an on-site recovery process to treat it obtaining high quality humic fertilizers.
BIOFERLUDAN aims to implement in biogas plants a new process to obtain liquid fertilizers with high organic matter content, in form of humic substances, recovering them from the digestate. Based on previous R&D works done by LRE, a biogas plant which use BIOFERLUDAN process will produce a minimum of 60L of fertilizer per ton of digestate. The implementation of the new solution will mean around 450.000 /year of potential incomes for each plant.
Being a great business opportunity for LRE, the success of this approach relays on the fact that it will constitute a business and improvement opportunity for clients (biogas plants) as well as they will obtain outcomes such as:
? Improved efficiency and productivity of the biogas plant recovering up to 55% and 25% of thermal and electrical energy surplus respectively produced
? Diminution of operating cost reducing up to 50% volume of digestate managed (current digestate management cost reaches average annual expenditure of EUR 90,000 for each biogas plant)
? Increased revenues by commercialisation of high quality fertilizers (450.000 /year)
? An estimated return period of the investment of 1,5 years
BIOFERLUDAN success will come from the fact that THERE IS NOT any so competitive solution in the market and, what else, it will suppose an estimated annual turnover of 315 million considering its implementation in at least 10% of the current 7000 EU biogas plants.";71429;50000;H2020-SMEINST-1-2014;SME-1;Ludan Renewable Energy Espaa S.L.;ES;;; 194389;645769;C-FOOT-CTRL;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Developing on line tools to monitor, control and mitigate GHG emissions in WWTPs;1/04/2015;31/03/2019;;"C-FOOT-CTRL aims to develop, test and validate a new software tool for the online monitoring, control and mitigation of the carbon footprint of wastewater treatment plants (WWTPs). Gaseous emissions are emitted from various stages of treatment in a WWTP. Currently, in developed countries the energy required for wastewater treatment accounts for approximately 3% of the total electrical load. Also, WWTPs are the biggest single energy consumers of municipalities with a share of 20% of the total energy consumption. The typical energy efficiency of WWTPs in Europe is less than 50%, when energy efficiency is defined as the ratio of electricity generated at WWTP to the electricity needed from grid to operate the WWTP. Strategies to decrease the required amount of energy may in fact cause greater harm due to the increase of GHG emissions. Various greenhouse gas emissions are associated with the construction and operation of WWTPs. These include carbon dioxide, methane, nitrous oxide, with nitrous oxide being 298 times more harmful than CO2. The development of a tool that will be able to accurately record on line the various gaseous emissions during the construction and in the different treatment processes of WWTPs is important in order to (i) track the emissions at the moment of occurrence (ii) immediately apply measures to reduce gaseous contaminants and to (iii) link the gaseous emission with a particular activity in the plant.

The on line GHG emissions monitoring and control system will be an innovative, low cost and flexible system based on wireless sensor networks for monitoring and supervising activities aiming to reduce GHG emissions during the operation of WWTPs at all stages (pre-treatment, primary treatment, biological treatment, tertiary treatment).";711000;711000;H2020-MSCA-RISE-2014;MSCA-RISE;NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA;EL;"AERIS TECNOLOGAS AMBIENTALES S.L.;UNISENSOR SENSORSYSTEME GMBH;UNIVERSITAT AUTONOMA DE BARCELONA;BRUNEL UNIVERSITY LONDON";"ES;DE;UK"; 194457;646568;FLEXMETER;SIGNED;H2020-EU.3.3.4.;LCE-07-2014;H2020;Flexible smart metering for multiple energy vectors with active prosumers;1/01/2015;31/12/2017;;"The introduction of the electricity market, the widespread diffusion of distributed generation from renewable and non-programmable energy sources and the need for storage are quickly changing the problems that Transmission and Distribution system operators have to face in their activity and are requiring a smarter grid. A first step in this direction is the development and installation of a flexible smart metering architecture for multiple energy vectors. Up to now the smart meters that in some countries are being installed at the users are nearly only devoted to billing improvements. The new metering systems must go much further to provide their contribution to various objectives such as end-user affordability of electricity, energy and market efficiency improvement, CO2 emissions and pollutants reduction. In the FLEXMETER project a flexible, multi-utility, multi-service metering architecture will be designed and deployed in two demonstrators. Simple off-the-shelf meters will be placed at the users for electric, thermal and gas metering; they will communicate with a building concentrator, where the smartness of the metering system will reside. A central cloud system will collect data from the building concentrators and from MV/LV substation meters. Data collection, fusion and mining algorithms will be adopted. The proposed architecture will allow for innovative services for the prosumers (e.g. analysis of the energy consumption), for the Distribution System Operators (DSOs) (e.g. fault detection, network balancing and storage integration) and for the retail market. Also demand side management devices could be plugged into the system. In the FLEXMETER project two pilot applications in two different countries (Italy and Sweden), on real systems, with the involvement of the local DSOs and volunteer prosumers will be demonstrated. The results on the demonstrators will then be scaled up to the size of the cities in order to evaluate the advantages on a real scale.";3869607,25;3197791,38;H2020-LCE-2014-3;IA;POLITECNICO DI TORINO;IT;"TELECOM ITALIA SPA;E.ON SVERIGE AB;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;UNIVERSITATEA POLITEHNICA DIN BUCURESTI;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;STMICROELECTRONICS SRL;INSTITUT POLYTECHNIQUE DE GRENOBLE;SIVECO ROMANIA SA;IREN SPA;IREN ENERGIA SPA;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"IT;SE;RO;DE;FR;BE"; 194723;651414;TM Field Analyzer;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.7.";DRS-17-2014-1;H2020;Developing a monitoring system for urban gas pipelines by utilizing state of the art accelerometers, advanced signal processing, and advanced intelligent algorithm based recognition;1/10/2014;28/02/2015;;"The gas grid monitoring systems cannot reliably estimate incident risks nor detect and isolate faults. At best, there are automatic solutions to avoid abrupt incidents. Incipient as well as intermittent fault detection and isolation still occurs randomly. Also, more than 50% of Europes ageing infrastructure has been built before 1983, while gas consumption continues to grow. Regarding safety, although the standards and regulations enable to mostly avoid abrupt failures, the current maintenance requirements incur excessive costs for gas grid operators. E.g. in Germany, grid leakages are controlled by expensive airborne LIDAR monitoring systems. This is especially problematic in urban environments, in which most of the consumers are situated- without viable alternatives, grid operators must accept the cost.

Nevertheless, recent advancements in remote measurement technologies enable to develop substantially more effective grid monitoring solutions. For example, THE Systems and its team has already proven the viability of networked accelerometers for continuous grid monitoring tasks (THE Systems has tested the solution in an industrial environment in Finland).

As a result of this project, THE Systems will combine state of the art accelerometers with advanced signal processing based on computationally efficient algorithms. The uniqueness for urban settings stems from the nodes highly effective dampening features and the algorithms non-parametric, multivariate, and non-linear characteristics that operate despite high rates of random noise. Thus, it will be possible for grid operators to continuously detect and isolate faults in urban gas networks in an economically feasible manner. The broader impact will be an increase in urban gas grid safety, and at least a 50% reduction in respective grid maintenance costs. For THE Systems, TM Field Analyzer could generate up to 70 mEUR by year 5 after the product launch, and increase the number of staff by at least 70 employees.";71429;50000;H2020-SMEINST-1-2014;SME-1;THE Systems OU;EE;;; 194346;645553;DANCE;SIGNED;H2020-EU.2.1.1.;ICT-31-2014;H2020;Dancing in the Dark;1/01/2015;31/12/2017;;"The baby, assailed by eyes, ears, nose, skin, and entrails at once, feels it all as one great blooming, buzzing confusion (W.James Principles of Psychology, 1890). The hyper-connected teenager may not be far from such a state of confusion. Information overload leads to new cognitive and attention problems with social consequences, as seen in dramatic growth of attention disorders. Too much information leads to emotional and social malfunctioning, such as in autism. In the non-clinical population, continuously bombardment of the senses from multiple sources may lead to blunting and cause a cognitive or emotional blindness that has undesirable social and cultural consequences. DANCE addresses the role of multisensory information and the risks of overload by creating sensory deprivation as a means of sharpening the senses. DANCE not only want to look at how dance can influence socio-emotional perception in healthy individuals, but also focus on the congenitally blind. DANCE will compare social perception of dance and participation-blindness, found naturally in the congenitally blind, and induced in normally seeing subjects. DANCE will lead to the development of ICT (1) to treat the individual as an interactive participant in auditory perception rather than as a passive receiver; (2) to enable blind people to perceive movement by sensory substitution by means of innovative techniques of interactive sonification and active (embodied) music experience; (3) to integrate the individual experience and social creation process; (4) to assess and measure cognitive and cultural enhancement through non-verbal, full-body expression, emotion,and entrainment, and to explore how non verbal emotion dimensions can contribute to sensory substitution in the perception of dance and movement in general, for both blind and seeing people; (5) to explore and integrate theories of artistic creativity and to inspire novel scientific research challenges.";1276250;1276250;H2020-ICT-2014-1;RIA;UNIVERSITA DEGLI STUDI DI GENOVA;IT;"KUNGLIGA TEKNISKA HOEGSKOLAN;UNIVERSITEIT MAASTRICHT";"SE;NL"; 194610;649724;COMBI;SIGNED;H2020-EU.3.3.6.;EE-12-2014;H2020;Calculating and Operationalising the Multiple Benefits of Energy Efficiency Improvements in Europe;1/03/2015;28/02/2018;;"In recent years, research has shown that energy savings resulting from energy efficiency improvements have wider benefits for the economy and society such as increases in employment, GDP, energy security, positive impacts on health, ecosystems and crops or resource consumption. In order to develop more cost-effective energy efficiency policies and optimised long-term strategies in the EU, these multiple benefits have to be accounted for more comprehensively in the future.
Although this field of research is growing, the findings are disperse and mostly have important gaps regarding geographic, sectorial or technical measure coverage and findings vary largely. This makes a consideration of multiple benefits in policy making and policy evaluation difficult today.
The proposed project addresses these issues and aims at closing the identified gaps by five central research innovations: 1) data gathering on energy savings and technology costs per EU country for the most relevant 20 to 30 energy efficiency measures in the residential, commercial, industrial and transport sectors, 2) developing adequate methodologies for benefit quantification, monetisation and aggregation, 3) quantifying the most important multiple benefits and where adequate, monetising, 4) developing an openly available calculation tool that greatly simplifies the evaluation of co-impacts for specific energy efficiency measures to enable decision-making and 5) developing a simple online visualisation tool for customisable graphical analysis and assessment of multiple benefits and data exportation. Project outcomes can thus directly be used by stakeholders and will help to define cost-effective policies and support policy-makers and evaluators in the development and monitoring of energy efficiency strategies and policies in the future.";996548,75;996548,75;H2020-EE-2014-2-RIA;RIA;WUPPERTAL INSTITUT FUR KLIMA, UMWELT, ENERGIE GMBH;DE;"UNIVERSITEIT ANTWERPEN;THE UNIVERSITY OF MANCHESTER;ABUD MERNOKIRODA KFT;COPENHAGEN ECONOMICS AS";"BE;UK;HU;DK"; 194504;647490;COBHUNI;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Contemporary Bioethics and the History of the Unborn in Islam;1/09/2015;31/08/2020;;"COBHUNI will for the first time provide a comprehensive investigation of the History of the Unborn in Islam until today. This aims at diversifying our understanding of how pre-natal life is conceptualized in texts of Islamic normativity. At the center will be the analysis of statements in the Quran and the prophetic sayings (Hadith) relating to the unborn and the commentary tradition which evolved around them over ca. the last millennium. The objectives of COBHUNI: 1. Thematically: Showing how processes of communication a) between religious communities, b) different regions within the Muslim community, and c) the emergence of modern medicine impacted on the imagination of the unborn. 2. Conceptually: Drawing on three new approaches in the study of Islam: a) emergence of Islam within the context of late antiquity, b) canonization studies, and c) study of exegetical literature. 3. Methodologically: Developing and applying computerlinguistic approaches to Arabic text material and thus improving significantly on the state of the art of Arabic Digital Humanities. The realization will encompass the analysis of the text material along two axes. Vertical axis: citations and cross-referencing within the exegetical tradition; Horizontal axis: contextualizing the exegesis and scrutinizing links to other genres. I have been working on contemporary Islamic Bioethics since 2003 and since 2008 I have broadened my research to the historical scope of the topic. With my comprehensive experience in the study of Contemporary Islamic Bioethics and historical texts from Islamic Normativity and my knowledge in the study of Arabic Quran and Hadith exegesis I will be able to successfully lead this cutting-edge project. My team will generate additional data and enhance the IT applications necessary for its analysis. My project will offer powerful approaches to show the complex web of influences impacting on the imaginations of the unborn in Islam.";1956338;1956338;ERC-2014-CoG;ERC-COG;UNIVERSITAET HAMBURG;DE;;; 194484;647073;FORCASTER;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Force, Motion and Positioning of Microtubule Asters;1/07/2015;30/06/2020;;"Cells must move and position internal components to perform their function. We here focus on the physical designs which allow microtubule (MT) asters to exert forces in order to move and position themselves in vivo. These are arrays of MTs radiating from the centrosome, which fill up large portions of cells. They orchestrate nuclear positioning and spindle orientation for polarity, division and development. Forces that move asters are generated at nanometer and second scales by MT-associated motors from sites in the cytoplasm or at the cell surface. How MTs and force-generators self-organize to control aster motion and position at millimeter and hour scales is not known. We will use a suit of biophysical experiments and models to address how aster micro-mechanics contribute to aster migration, centration, de-centration and orientation in a single in vivo system, using the early stages of Sea urchin development as a quantitative model.
We aim to: 1) Elucidate mechanisms that drive aster large-scale motion, using sperm aster migration after fertilization during which asters grow and move rapidly and persistently to the large-egg center. We will investigate how speeds and trajectories depend on boundary conditions and on the dynamic spatial organization of force-generators.
2) Implement magnetic-based subcellular force measurements of MT asters. We will use this to understand how single force-events are integrated at the scale of asters, how global forces may evolve will aster size, shape, in centration and de-centration processes, using various stages of development, and cell manipulation; and to compute aster friction.
3) Couple computational models and 3D imaging to understand and predict stereotyped division patterns driven by subsequent aster positioning and aster-pairs orientation in the early divisions of Sea urchin embryos and in other tissues.
This framework bridging multiple scales will bring unprecedented insights on the physics of living active matter.";2199310;2199310;ERC-2014-CoG;ERC-COG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194420;646159;BASMATI;SIGNED;H2020-EU.2.1.2.1.;NMP-05-2014;H2020;Bringing innovAtion by Scaling up nanoMATerials and Inks for printing;1/01/2015;31/12/2017;;"The BASMATI project will address the development of active nanomaterial and electrochemical inks for printing technologies such as screen and inkjet printing. The ink formulations will be tested on a case study through printing of a thin film battery. The general objective of the project is to scale-up the ink formulations to pilot line ensuring large volume fabrication of new products with improved properties for printing application. Especially, the particles definition at nanometer size will be one key parameter for the compatibility in ink jet printing. Moreover, knowledge will also be generated on electrochemical inks formulation and additives used in order to stabilize the ink products.
The concept of nanomaterials for printing application will be applied to flexible printed electronics and more specifically to printed batteries. These printed batteries are needed as power source at the closest part and the development of printed electronics so as to as to design an all-in-one product allowing better process ability in ink jet process for 3D design and 2D screen printing process.
BASMATI will also provide a new source of nanomaterials for the formulation of conductive and electrochemical inks. These nanomaterials will be metallic particle (Ni, Cu, Al) that will be usable for numerous applications of printed electronic on flexible substrate. Another type of nanomaterials will be layered positive active material such as LiNi1/3Mn1/3Co1/3O2 (NMC) and olivine LiFePO4 (LFP).
The know-how level reached in BASMATI by research groups and transfer and up-scale to pilots (TRL 6) at SMEs and industry facilities will pave the way for future industrialization of inks formulations production for mass markets such as printed electronics. The compatible formulations in high throughput technologies will ensure a reproducible and reliable process for sophisticated fully digital micro-structured devices. Nanosafety will also be carefully considered in BASMATI project.";6136703,75;5000359,75;H2020-NMP-PILOTS-2014;IA;UMICORE;BE;"PRAYON S.A;BELIFE;ARISTOTELIO PANEPISTIMIO THESSALONIKIS;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;MICRODROP TECHNOLOGIES GMBH;VARTA MICROBATTERY GMBH;GWENT ELECTRONIC MATERIALS LIMITED;GENES'INK;ACONDICIONAMIENTO TARRASENSE ASSOCIACION;JSR MICRO NV";"BE;EL;FR;DE;UK;ES"; 194374;645733;Sustain-Owner;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Sustainable Design and Management of Industrial Assets through Total Value and Cost of Ownership;1/01/2015;31/12/2018;;"SoThe project will examine the potential of Total Value and Cost of Ownership (TVO, TCO) for supporting the design and through-life management of industrial assets.
Until now, some leading companies that are aware of all the costs throughout the asset life cycle use TCO to support procurement, operations and maintenance decisions. The benefit of using TCO is that a decision maker could be incentivised to go beyond the consideration of capital expenditure, and think of the potential whole-life cost arising through the use of their assets. In this regard, TCO helps achieving a cost-efficient life cycle management of the assets owned by the company. But TCO models are still poorly practiced in industry, in spite of their advantages. Further on, the flavour of the day in the industrial and academic world is to encourage innovative thinking to extract the maximum value from the assets, instead of thinking only about cost. Value can be tangible or intangible, and is determined by the organization and its stakeholders, thus TVO extends cost-based decisions. Although the importance of value maximisation in physical asset management is currently accepted, there are few works clarifying what value means, how to identify and quantify value, how to base decisions on it. The purpose of the project is to study the evolution of TVO and TCO as used in industry and understood by academics, with the aim to develop a framework for understanding, quantifying, and using TVO / TCO for decision-making. Overall, we aim at studying how asset life cycle management is possible thanks to TVO / TCO, providing the asset owner the capability to develop a sustainable factory according to the economic, social and environmental requirements of the local industry.Cross-fertilization of research and industry will be achieved through knowledge sharing between academics and industrial experts involved through interviews and workshops. Publications will provide outputs to promote knowledge sharing.";450000;450000;H2020-MSCA-RISE-2014;MSCA-RISE;POLITECNICO DI MILANO;IT;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UNIVERSIDAD DE SEVILLA";"UK;ES"; 194416;646130;ATLASS;SIGNED;H2020-EU.2.1.2.1.;NMP-04-2014;H2020;Advanced high-resolution printing of organic Transistors for Large Area Smart Surfaces;1/03/2015;31/08/2018;;Bringing intelligence and communication to everyday objects is a major challenge for future electronics. This Internet of Things concept envisions wide dissemination with new performances: robustness, large area, flexibility, eco-efficient large volume manufacturing at low cost. Beyond current TOLAE demonstration, a major technology jump driving the scalability towards nanoscale resolution via high-definition cost-effective printing is required to deliver the properties and electrical performances expected by applications. ATLASS Innovation Action takes this huge step by bringing high resolution technologies to the printing industries for the demonstration of products at TRL6 in high impact markets. New multifunctional high-performing inks (semiconductor mobility >1cm2/Vs, dielectrics, ferroelectrics) and high-resolution (down to 500nm and ~100nm thickness) R2R/S2S printing including nano-imprinting and gravure printing will be engineered and scaled-up on pre-industrial pilot lines, enabling high performance devices (speed ~ 10 MHz). In-line control and novel automatic optical inspection tools and methodology will be installed to ramp-up the yield of developed processes (>99%) thus enabling cost-efficient fabrication of advanced circuits (>1000 transistors, 50kHz clock rate). The technology capability is benchmarked with conventional TOLAE process and demonstrated with 4 applications in the field of Interactive objects and Sensing surfaces (temperature tag for smart food packaging, electronic label for logistics, impact force sensing foils for automotive safety -, proximity sensing for safer human-robot collaboration ). With a consortium of 11 top companies (7 SMEs) from the cutting-edge, fast growing printed electronics sector and 4 RTOs with high-level technology expertise, ATLASS will strongly impact the global market of sensors, labels and smart objects expected to reach revenue of several EUR billion with printed sensors share of EUR 644 million by 2022.;7883005;6508043,38;H2020-NMP-PILOTS-2014;IA;MERCK CHEMICALS LTD;UK;"FLEXENABLE LIMITED;THE SHADOW ROBOT COMPANY LIMITED;JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;GRT GMBH&CO.KG.HAMM;MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN;ARKEMA FRANCE;GESELLSCHAFT FUR ANGEWANDTE MIKRO UND OPTOELEKTRONIK MIT BESCHRANKTERHAFTUNG AMO GMBH;CONCEPT TECH GMBH;TECHNISCHE UNIVERSITEIT EINDHOVEN;EFFICIENT INNOVATION SAS;TEKNOLOGIAN TUTKIMUSKESKUS VTT;THIN FILM ELECTRONICS AB;IN-CORE SYSTEMES SARL;Teknologian tutkimuskeskus VTT Oy";"UK;AT;FR;DE;NL;FI;SE"; 194748;651786;Robotic insulation;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.3.";SIE-01-2014-1;H2020;Fast and economic insulation of buildings using robotic systems;1/11/2014;30/04/2015;;"Thermal insulation of walls and floors are the greatest contributors to energy performance of buildings, but are some of the most challenging measures to implement in old infrastructures. Current methods for wall and floor insulation are disruptive, labour intensive and can be very costly. This severely limits the uptake and discourages most stakeholders from undertaking insulation works

Solving this technical challenge would open up a clear and well defined business opportunity. Driven by legislative targets to reduce energy consumption, this translates into a vast market and an immense aggregate welfare benefits to society.

To meet this demand, Q-Bot has developed an innovative process using a remotely controlled robotic device that can survey, assess and apply insulation. For both under floor and solid wall insulation Q-Bot radically reduces the time, cost and disruption compared to traditional methods.

The project will work with key stakeholders to further understand their needs. By preparing an in-depth market study and an Innovation Strategy Development plan, Q-Bot aims to effectively target high potential markets. The projects measurable KPIs, the company aims to deliver a dramatic improvement to the productivity, safety and the image of the construction industry. This would result in a measurable, positive and lasting impact on the environment and society across Europe and beyond.";71429;50000;H2020-SMEINST-1-2014;SME-1;Q-BOT LIMITED;UK;;; 194489;647204;QUINCY;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Quantifying the effects of interacting nutrient cycles on terrestrial biosphere dynamics and their climate feedbacks QUINCY;1/09/2015;31/08/2020;;Nutrient availability plays a pivotal role in the response of terrestrial ecosystems to increasing atmospheric CO2 and climate change. The global role of nutrients is only poorly understood quantitatively, limiting the predictive understanding of terrestrial biosphere - climate feedbacks. The first generation of global nutrient-carbon cycle models shows strongly diverging estimates of the nutrient effect, resulting from lacking integration of ecosystem observations and fundamental uncertainties in the representation of governing processes. The objective of QUINCY is to clarify the role of the interacting terrestrial nitrogen and phosphorus cycles and their effects on terrestrial C allocation and residence times as well as terrestrial water fluxes. QUINCY will create a novel, predictive framework founded on the principle of resource optimisation, shifting the paradigm of terrestrial biosphere modelling towards an active biological control of matter flows. QUINCYs main themes are (i) the effects of nutrient availability on plant photosynthesis and respiration, explicitly taking the energy requirement of nutrient acquisition into account, and (ii) the effects of vegetation-soil interactions, namely rhizosphere processes, on plant nutrient availability and soil C turnover. To corroborate these theoretical concepts, QUINCY will synthesise existing and ongoing ecosystem monitoring and manipulation studies. To specifically test emerging hypotheses on the effects of rhizosphere priming on soil C storage and plant nutrition - and to provide currently lacking data for soil-vegetation models - QUINCY will establish a tree mesocosm, elevated CO2 experiment. The novel model concepts will be consistently integrated to form a new general terrestrial biosphere model. For the first time, QUINCY will be able to address the multiway interactions of carbon, nitrogen, phosphorus and water cycles globally in a theoretically well-founded way commensurate with ecosystem observations.;2000000;2000000;ERC-2014-CoG;ERC-COG;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 194708;651131;MOSART;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Advanced Automated Process for Low Cost Efficient Custom Mosaic Manufacturing;1/10/2014;31/01/2015;;"'MOSART aims to bring to full industrialization and commercialization a proprietary advanced manufacturing system for high quality custom-made mosaics. Europe accounts for 30% global tile production and 26% consumption market share. Europe is recognized worldwide for innovative designs and concepts but high manufacturing costs have begun to deplete the design and art industry. The quality of mosaics have diminished immensely and jobs have been removed from Europe and outsourced to India and China. Artaic strives to resolve these issues and position European design innovation as a leader on a global stage, while returning jobs back to Europe, fostering creativity and stimulating the European art and construction market.
Today the process stages of mosaic artwork from design through installation are complicated and expensive with long lead times due to manual fabrication and lengthy supply chains. Artaics state of the art patent-pending robotic technology and CAD mass-customization software allow to automate production and assembly of large scale, high volume affordable custom-made mosaics with unparalleled speed, efficiency, flexibility, and cost savings. First generation robotic pilot production line proved to be 10x faster than the traditional method and the prototyped second generation robot, called 'TileJet', adds more speed (100-200x) and productivity together with accuracy and flexibility. Such a technology has reached now a TRL of 8.
MOSART Phase 1 project aims at establishing a robust industrialization and operational plan, at assessing the feasibility of a customer-centred web portal enabling direct B2C sales, identifying all stakeholders in the value chain securing appropriate sale channels and strategic partnerships and at strengthening the business model through an in-depth analysis of customer segments and financial projections.'";71429;50000;H2020-SMEINST-1-2014;SME-1;ARTAIC LTD;UK;WELLNESS SPA ITALY CO. LTD;MT; 194458;646573;progRESsHEAT;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-04-2014;H2020;Supporting the progress of renewable energies for heating and cooling in the EU on a local level;1/03/2015;31/10/2017;;"The RED, the EED and the EPBD (recast) require member states to develop ambitious policies for sustainable heating and cooling. The objective of this project is to assist policy makers at the local, regional, national and EU-level in developing and implementing integrated, effective and efficient policy strategies achieving a fast and strong penetration of RES and EE in heating and cooling. This will include the analysis of cross-sectoral effects between RES and EE measures in industry, buildings and DHC as well as the link to the electricity system.
The core part of the proposal is the communication and capacity building process with policy makers, administrative staff and other stakeholders at the local, regional and national level including the set up of policy group meetings, expert consultations, experience sharing and capacity building workshops as well as webinars. The process will focus on 6 target countries and regions. Together with the authorities heating and cooling strategies will be developed through a profound analysis of their specific situation including barriers & drivers and a model based assessment of policy intervention in scenarios up to 2050. progRESsHEAT will assist national policy makers in implementing the policies published in the national heating and cooling plans in an effective and efficient way by the means of a model-based quantitative impact assessment of local, regional and national policies up to 2050. Data, scenarios and recommendations will be provided for the target countries. Dissemination activities will transfer results to other countries and the EU-level.
Policy makers and other stakeholders will be strongly involved in the process, learn from the experience in other regions and gain deep understanding of the impact of policy instruments and their specific design. This will provide the ground for favourable, stable conditions for increasing the efficiency and the penetration of renewable heating and cooling in Europe.";1728305,6;1728305;H2020-LCE-2014-3;CSA;TECHNISCHE UNIVERSITAET WIEN;AT;"IREES GMBH - INSTITUT FUR RESSOURCENEFFIZIENZ UND ENERGIESTRATEGIEN;O.Oe. Energiesparverband;EE ENERGY ENGINEERS GMBH;GATE 21;AGENTIA PENTRU MANAGEMENTUL ENERGIEI SI PROTECTIA MEDIULUI BRASOV;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;MESTO LITOMERICE;DANMARKS TEKNISKE UNIVERSITET;ENERGY CITIES/ENERGIE-CITES ASSOCIATION;INEGI - INSTITUTO DE CIENCIA E INOVACAO EM ENGENHARIA MECANICA E ENGENHARIA INDUSTRIAL";"DE;AT;DK;RO;CZ;FR;PT"; 194597;649669;SMART-UP;SIGNED;H2020-EU.3.3.7.;EE-10-2014;H2020;Vulnerable consumer empowerment in a smart meter world;1/03/2015;28/02/2018;;"The overarching aim of SMART-UP is to encourage the active use of Smart Meters and In-House Displays by vulnerable customers, in those Member States where the roll-out of Smart Meters has been embarked upon. Indeed, previous studies have shown that Smart Meters do not lead to energy savings in the residential sector unless households actively use them and are encouraged to modify their everyday practices. Our project intends to fill in this gap, while also raising awareness on demand response services.
The way we intend to do so is by developing a training program for installers, social workers and other frontline staff in contact with vulnerable people, so that they can inform vulnerable consumers about the benefits brought about by smart metering and advise them on how to use their Smart Meter and In Home Display (IHD) units (where fitted) to best effect, each time they are in contact with them. Indeed, most vulnerable and low-income householders require a one-to-one and on-going support.
The training packages will be tested and improved before getting disseminated towards the major actors involved in smart meters deployment (DSOs, energy utilities, installers). From 50 to 100 installers or other frontline staff will be trained in each project partners country. Each of them will deliver face-to-face advise to 10 to 20 households, so as to reach 1,000 households in each country. DSO and energy utilities (depending on the national context) will be involved to provide the necessary support for this experiment and to ensure further dissemination of the training packages.
Besides empowering vulnerable consumers, the project will serve to get some feedback on their specific needs and on the ways to appropriately communicate with them and help them take profit of smart metering. The project will also help consolidate data on how much energy can be saved if vulnerable householders are empowered to make best use of the opportunities that Smart Metering offers.";791493;791493;H2020-EE-2014-3-MarketUptake;CSA;ALPHEEIS SAS;FR;"AISFOR SRL;PROJECTS IN MOTION LIMITED;ASOCIACION ECOSERVEIS;NATIONAL ENERGY ACTION LBG";"IT;MT;ES;UK"; 194469;646717;TUNNELCHEM;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Atom-Tunneling in Chemistry;1/07/2015;30/06/2020;;"Quantum mechanical tunneling of atoms is emerging as an ubiquitous phenomenon in chemistry. Every chemical reaction that includes a hydrogen transfer can be expected to be influenced by tunneling at room temperature. While simulations can monitor tunneling directly, experimental approaches can only detect the consequences. Theoretical investigations, as planned in TUNNELCHEM, have to keep up in order to aid the rational interpretation. We build on significant algorithmic breakthroughs recently achieved in the applicant's group, which allow accurate predictions of tunneling rates in larger systems than previously possible. These possibilities are to be exploited, which requires a big, combined project that can afford high-risk components.

In TUNNELCHEM, we will investigate aspects of tunneling in several different areas of chemistry: biochemistry, astrochemistry, catalysis and algorithmic development. The investigation of tunneling contributions to enzymatic reactions will allow to plan modifications which increase the selectivity and efficiency. Several astrochemical processes can only be understood if their tunneling contributions are properly accounted for. Accurate tunneling rates will significantly improve the predictive power of models of the interstellar medium. Many processes in homogenous and heterogenous catalysis involve tunneling. A fundamental understanding of the principles involved allows for the design of improved catalysts. Further development of methods and algorithms in accordance with the demands of the applications is required. TUNNELCHEM will shift the present paradigm from descriptive investigations to a rational design of catalysts enabled by a mechanistic understanding of atom tunneling processes.

Only such a combined effort may allow us to understand the principles of tunneling in chemistry and to develop concepts to exploit the tunnel effect for optimizing reactivity and selectivity of chemical reactions in biochemistry and catalysis.";1986750;1986750;ERC-2014-CoG;ERC-COG;Universitaet Stuttgart;DE;;; 194410;646039;ERANet SmartGridPlus;SIGNED;H2020-EU.3.3.2.;LCE-18-2014;H2020;ERA-Net Smart Grids Plus: support deep knowledge sharing between regional and European Smart Grids initiatives;30/01/2015;29/01/2020;;"'From local trials to a European knowledge community'.

The challenges of modernising the electricity grids in Europe lies in enabling an increased flexibility of the European power system, efficiently providing increased transfer capacity and enabling an active participation of users and new market actors (by providing the information, services, market architectures and privacy guarantees).
To address these challenges, innovation is needed in system integration, interoperable technologies, services, tools, co-ordination schemes, business processes, market architectures and regulatory regimes to plan, build, monitor, control and safely operate end-to-end networks in an open, competitive, decarbonised, sustainable and climate-change resilient market, under normal and emergency conditions.

The major challenge is now to overcome the fragmentation of knowledge and accelerate knowledge exchange between the already existing demonstration projects and R&D initiatives with the goal to enable them to develop European wide interoperable solutions, according to a common reference architecture. With this, critical masses shall be reached in the development of a European market for smart grids technology providers and smart grids service providers.

This initiative does not intend to find the final specifications for smart grids, but to organise the learning down to regional Smart Grids stakeholders, beyond the demonstration phase towards implementation.

The overall goal of the ERA-Net Smart Grids Plus is to support deep knowledge sharing between regional and European Smart Grids initiatives by financing 15-20 transnational projects on applied research, piloting and demonstration in the field of Smart Grids, taking a next step in Smart Grids development building on the knowledge base, R&D initiatives as well as research and demonstration facilities already in place at regional, national and European level. It will coordinate during 2015-19 national and regional RDD budgets of more than 30 M.'";44563055;13511432,22;H2020-LCE-2014-3;ERA-NET-Cofund;BUNDESMINISTERIUM FUER VERKEHR, INNOVATION UND TECHNOLOGIE;AT;"FEDERAL DEPARTMENT FOR ENVIRONMENT TRANSPORTS ENERGY AND COMMUNICATION;FOND ZA ZASTITU OKOLISA I ENERGETSKU UCINKOVITOST;INNOVAATIORAHOITUSKESKUS TEKES;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;SCOTTISH ENTERPRISE;NEDERLANDSE ORGANISATIE VOOR WETENSCHAPPELIJK ONDERZOEK;AGENCE DE L'ENVIRONNEMENT ET DE LA MAITRISE DE L'ENERGIE;FORSCHUNGSZENTRUM JULICH GMBH;STATENS ENERGIMYNDIGHET;Ministerul Educatiei Nationale;SERVICE PUBLIC DE WALLONIE;REGIONE LOMBARDIA;NORGES FORSKNINGSRAD;NARODOWE CENTRUM BADAN I ROZWOJU;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;MINISTRSTVO ZA INFRASTRUKTURO;VALSTS IZGLITIBAS ATTISTIBAS AGENTURA;AGENTSCHAP VOOR INNOVATIE DOOR WETENSCHAP EN TECHNOLOGIE;LATVIJAS ZINATNU AKADEMIJA;ENERGINET.DK;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"CH;HR;FI;AT;UK;NL;FR;DE;SE;RO;BE;IT;NO;PL;TR;ES;SI;LV;DK;PT"; 194442;646457;SECURECHAIN;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.3.1.;H2020-EU.3.3.2.";LCE-14-2014;H2020;Securing future-proof environmentally compatible bioenergy chains;1/04/2015;31/03/2018;;SecureChain promotes a Sustainable Supply Chain Management (SSCM) that meets highest environmental quality standards and targets local biomass suppliers, energy producers and financial sector players to mobilise more biomass, maximise the share of sustainable bioenergy in the final energy consumption, and reduce the transaction costs for further market uptake of most efficient systems in six European model regions. An open call for SSCM pilot projects is launched encouraging market actors to mobilise and secure additional supplies of biomass from regional sources. Following a merit-based, objective competition, selected SMEs are awarded 15-20 Innovation Vouchers for the realisation of proposed SSCM pilot projects with the support of specialised advisors. Learning Labs for SME clusters support the implementation of most sustainable and energy efficient solutions in each model region. Tested quality assurance tools are readily installed in the pilots and SMEs receive proper training. A complete LCA of pilot supply chains evaluates their broader environmental and socio-economic impacts, ensuring that QA protocols meet eligible international sustainability standards for high efficiency and low carbon footprint. Suppliers are prepared for and ultimately acquire sustainability certification via independent audits. To facilitate critical financial proofs for market actors and financiers, a risk assessment of supply chains in line with a close mentoring of pilot teams by financial advisors is carried out. Roadshows promoting the pilots showcase that future-proof investment proposals can attract local to international capital for secured implementation and upscaling of efficient solutions. SecureChain exploits and disseminates a broadly transferable SSCM model for local bioenergy chains that fosters sustainable, environmentally compatible mobilisation of biomass sources and a proactive promotion of the market through conscious investments into the bioenergy sector.;1809586,25;1809586,25;H2020-LCE-2014-3;CSA;B.T.G. BIOMASS TECHNOLOGY GROUP BV;NL;"ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;INTERNATIONALES INSTITUT FUR WALD UND HOLZ NRW EV;ENERGIKONTOR SYDOST AB;UNIVERSITAET FUER BODENKULTUR WIEN;CLIMATE BONDS INITIATIVE;UNIVERSITAT POLITECNICA DE CATALUNYA;DIN CERTCO GESELLSCHAFT FUER KONFORMITAETSBEWERTUNG MBH;MITTETULUNDUSUHING TARTU REGIOONI ENERGIAAGENTUUR;CLUSTER VIOENERGEIAS LAI PERIVALLONTOS DYTIKIS MAKEDONIAS;CENTRE TECNOLOGIC FORESTAL DE CATALUNYA";"EL;DE;SE;AT;UK;ES;EE"; 194331;645584;PRO4VIP;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;Innovative PROcurement for Visual Impaired People;1/02/2015;30/11/2016;;"Taking into account the objectives of Vision 2020, the WHO's 2006 initiative for the elimination of avoidable blindness. When globally people with low vision are increasing as a result of the ageing of the worlds population. Where low vision not only affects the independence but has significant psychosocial and economic impact on the individual, the family and society. Major consequences of vision impairment include a childs ability to pursue education and an adults ability for high quality employment, risk of falls, difficulties with daily living and increased dependence.

PRO4VIP project has the objectives of : (1) the creation of an European wide network of procurers (RITT, US, FVG, BFW, AQuAS); (2) the definition of a common innovation procurement roadmap in the short term and in the long term and (3) the definition of the public procurement of innovation procedure(s) that best meet(s) their needs (that could be either a Pre-Commercial Procurement (PCP) or a Public Procurement of Innovative Solutions (PPI) or both) and that in line with Vision 2020 would either support the early detection and the screening of functional low vision conditions or would support the provision for low vision services.

This will be achieved through a staged process whose main steps are: (1) the identification of the shared procurement needs; (2) the analysis of the state of the art, the technologies available in the market and the existing patents; (3) the engagement in open dialogues with other procurers, end-users and suppliers; (4) the analysis of the different public procurement of innovation options; and (5) the definition of the selected procurement procedure(s).

The consortium is an interdisciplinary team composed of procurers interested in the topic from different perspectives (Health, social & Assistive Technology), with entities having the expertise to support them in identifying their common needs, validate them with the end users, other procurers and the market.";607526,25;584926;H2020-ICT-2014-1;CSA;AGENCIA DE QUALITAT I AVALUACIO SANITARIES DE CATALUNYA;ES;"CONSORZIO PER L AREA DI RICERCA SCI ENTIFICA E TECNOLOGICA DI TRIESTE CONSORZIO AREA;BEDIN SARA;ZENIT ZENTRUM FUR INNOVATION UND TECHNIK IN NORDRHEIN-WESTFALEN GMBH;FUNDACION BARCELONA MACULA FOUNDATION RESEARCH FOR VISION;UNION EUROPEENNE DES AVEUGLES UEAASSOCIATION;BERUFSFORDERUNGSWERK DUREN GEMEINNUTZIGE GMBH ZENTRUM FUR BERUFLICHE BILDUNG BLINDER UND SEHBEHINDERETER MENSCHEN;ISTITUTO REGIONALE RITTMEYER PER I CIECHI DI TRIESTE;REGIONE AUTONOMA FRIULI-VENEZIA GIULIA;ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK;UNIVERSITA DEGLI STUDI DI SALERNO;UCL PARTNERS LIMITED";"IT;DE;ES;FR;UK"; 194474;646867;Learn;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Learning From Failing and Passing Executions At the Speed of Internet;1/10/2015;30/09/2019;;"Modern software systems must be extremely flexible and easily adaptable to different user needs and environments. However, this flexibility also introduces relevant quality issues. These problems are so common that is sufficient browsing the Web to find millions of reports about failures observed after updates and incompatibilities caused by the interaction of a newly installed component with the existing components.

The impact of problems introduced by end-users can be dramatic because end-users can easily modify applications, like developers do, but end-users have neither the knowledge nor the skill of developers, and they cannot debug and fix the problems that they unintentionally introduce. It is thus necessary to timely develop novel solutions that can increase the reliability of the moderns systems, which can be extended and adapted by end-users, with the capability to automatically address problems that are unknown at development-time.

The Learn project aims to produce innovative solutions for the development of systems that can work around the problems introduced by end-users when modifying their applications. The three key elements introduced by Learn to automatically produce a (temporary) fix for the software are: (1) the definition of the InternetLearn infrastructure, which is a network infrastructure that enables communication between every individual instance of a same program running at different end-users sites, thus augmenting each application with the capability to access a huge amount of information collected in-the-field from other sites; (2) the definition of analysis techniques that can learn the characteristics of successful and failed runs by monitoring executions in the field from a number of instances running at many end-user sites; and (3) the definition of techniques for the automatic generation and actuation of temporary fixes on an Internet (World) scale.";1141875;1141875;ERC-2014-CoG;ERC-COG;UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA;IT;;; 194693;650937;VEZ;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;VEZ;1/11/2014;31/08/2015;;"'VEZ will be a zero emission boat for public transports in water cities, featuring mission and characteristics at least similar to the typical Venice Vaporetto, which can be considered a worldwide reference for public water transports. VEZ will be powered by a hybrid energy generation and management system based on hydrogen-air fuel cells, roof mounted PV cells and electric batteries, demonstrating the possibility of reaching Zero emission in boat services even in such stressing conditions as in the Venice canals. It will exploit the advances that the automotive industry drove on those technological areas, particularly in Europe.
A few similarly powered boats exist for passengers' transports but for broader harbour waters or rivers. VEZ will be innovative as it will be conceived and designed for narrow and highly congested waters, by a whole systems engineering approach, optimizing the power system to be managed efficiently under the frequent start and stop requirements deriving from regular line service in relatively narrow and congested canals, such as the Venice Grand Canal, with potential application also in other worldwide 'water cities'. The low wave making hull will be optimized vs. power system and payload layout, manoeuvrability and safety requirements. The vessel will be an improvement also from the comfort point of view by the lower noise obtained and the integrated heat pump air conditioning. Another innovation, from a large fleet perspective, will be the lightweight Aluminium made hull, for better material recyclability and accommodation of the heavier energy generation and storage system.
Phase 1 will cover:
State of the art and market analysis of zero emission passenger boats;
Legal constraints, related to onboard fuel storage & handling;
Concept design;
VEZ functional and technical specification;
VEZ lifecycle cost estimate;
Phase 2 cost estimate (engineering and management, prototype construction, model test tank).'";71429;50000;H2020-SMEINST-1-2014;SME-1;IMS INDUSTRIE MECCANICHE SCARDELLATO SPA;IT;;; 194405;645963;SENSIBLE;SIGNED;H2020-EU.3.3.;LCE-08-2014;H2020;Storage-Enabled Sustainable Energy for Buildings and Communities;1/01/2015;30/06/2018;;"The project SENSIBLE addresses the call LCE-08-2014 by integrating electro-chemical, electro-mechanical and thermal storage technologies as well micro-generation (CHP, heat pumps) and renewable energy sources (PV) into power and energy networks as well as homes and buildings. The benefits of storage integration will be demonstrated with three demonstrators in Portugal, UK and Germany. vora (Portugal) will demonstrate storage-enabled power flow, power quality control and grid resilience/robustness in (predominantly low-voltage) power distribution networks under the assumption that these networks are weak and potentially unreliable. Nottingham (UK) will focus on storage-enabled energy management and energy market participation of buildings (homes) and communities under the assumption that the grid is strong (so, with no or little restrictions from the grid). Nuremberg (Germany) will focus on multi-modal energy storage in larger buildings, considering thermal storage, CHP, and different energy vectors (electricity, gas).
An important aspect of the project is about how to connect the local storage capacity with the energy markets in a way that results in sustainable business models for small scale storage deployment, especially in buildings and communities. SENSIBLE will also conduct life cycle analyses and assess the socio-economic impact of small-scale storage integrated in buildings distribution networks.
By integrating different storage technologies into local energy grids as well as homes and buildings, and by connecting these storage facilities to the energy markets, the project SENSIBLE will have a significant impact on local energy flows in energy grids as well as on the energy utilization in buildings and communities. The impacts range from increased self-sufficiency, power quality and network stability all the way to sustainable business models for local energy generation and storage.";15403636,38;11842396,76;H2020-LCE-2014-3;IA;SIEMENS AKTIENGESELLSCHAFT;DE;"LABELEC - ESTUDOS, DESENVOLVIMENTO E ACTIVIDADES LABORATORIALS SA;TECHNISCHE HOCHSCHULE NURNBERG GEORG SIMON OHM;EMPOWER IM OY;Adevice Solutions S.L.;INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;INDRA SISTEMAS SA;ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS;greenpower technologies;K & S GMBH PROJEKTMANAGEMENT;UNIVERSIDAD DE SEVILLA;THE UNIVERSITY OF NOTTINGHAM;MEADOWS OZONE ENERGY SERVICES LTD.;SIEMENS SA";"PT;DE;FI;ES;FR;UK"; 194401;645884;I3U;SIGNED;H2020-EU.3.6.;INSO-3-2014;H2020;Investigating the Impact of the Innovation Union;1/03/2015;28/02/2018;;"Innovation has been placed at the heart of the Europe 2020 strategy aimed at facing major structural changes, the increase of global competition and the current crisis, and to tackle major societal challenges such as climate change, energy and resource scarcity, health and ageing. The Innovation Union has the main objective to strengthen the European innovative potential, and sets 13 general objectives and 34 specific (policy) commitments associated to the objectives, and aimed at stimulating innovation.
The objective of this project is to deliver a system of assessment for the commitments. The approach starts from the evaluation of the state of achievement of the individual commitments, but puts crucial emphasis on their effects in the innovation system as a whole, as well as on the economy-wide effects of innovation. The basic idea is to retrace the entire chain of effects of the commitments, from their implementation to their final impact in terms of competitiveness, growth or employment.
The specific tasks that project sets out to undertake to achieve this are:
1) Data collection and identification of mechanisms;
2) Developing theoretical and econometric models in order to estimate the impact of the commitments;
3) Developing a conceptual model of the innovation system, leading to a reference tool on which the impact analysis of the commitments individually and as a whole will be based, and which will also play a role of interface between the assessments of the commitments impact and the macro sectoral econometric work.
4) A quantitative analysis of the commitments by use of the NEMESIS model, which is an existing macro-structural econometric model, but which will be modified and extended for the tasks at hand;
5) An ex-ante and ex-post policy assessment of the economic effects of the Innovation Union at European, national and regional levels;
6) To present policy conclusions and recommendations on the validation or the efficiency of the policies implemented.";2931486,25;2931486;H2020-INSO-2014;RIA;UNIVERSITEIT MAASTRICHT;NL;"SEURECO SOCIETE EUROPEENNE D'ECONOMIE SARL;SZKOLA GLOWNA HANDLOWA W WARSZAWIE;WIENER INSTITUT FUR INTERNATIONALE WIRTSCHAFTSVERGLEICHE;UNIVERSITETET I OSLO;ISTITUTO DI STUDI PER L'INTEGRAZIONE DEI SISTEMI (I.S.I.S) - SOCIETA'COOPERATIVA;UNIVERSITE LIBRE DE BRUXELLES;EKONOMSKI INSTITUT ZAGREB;ZENTRUM FUER EUROPAEISCHE WIRTSCHAFTSFORSCHUNG GmbH";"FR;PL;AT;NO;IT;BE;HR;DE"; 194733;651537;REVIVOS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;REVIVOS - REVIVING SINGERS THROUGH VOICE SYNTHESIS;1/11/2014;30/04/2015;;"Music Industry is seeking new forms of monetization of their catalogue. Online music distribution and current listening habits demand of innovative solutions for digital audiences that are today bigger than ever. Pop stars maintain a huge popularity years after their retirement or accidental decease. Moreover this interest gave recently a leap forward and moved to the stage, where holographic live shows revive artists in a mixed-reality concert.
In this scenario REVIVOS aims to commercialize a technology solution for synthesizing new songs with the voice of famous artists. The innovation of this project is the potential commercialization of Virtual Singers modeled from original artist recordings. The synthetic voice shall preserve not only their timbre but also the expression and singing style that make them unique. This project has a clear global dimension, focusing on the Western markets because they share a common popular music culture. Potential applications include among others the production of posthumous live shows, the release of new compositions, or the rejuvenation of the voice of a living or retired artist.
For the SME Instrument Phase 1, REVIVOS has as primary objective the realization of a study for the best business model for this new paradigm in the music and media industries. It consists of three stages: 1) Building a network of advisors; 2) Prototype and Demos preparation and 3) Business Plan elaboration. Outcomes shall define the implementation steps in a future Phase 2.
The team behind Voctro Labs has demonstrated excellence and capacity in the innovation related to Virtual Singers. Voctro Labs is an audio technology company specialized in singing voice synthesis. Cofounders are experts with more than 15 years of research and industrial experience. Founded in 2011, it is a spin-off of the Music Technology Group of the Pompeu Fabra University in Barcelona, a world-renowned research lab in sound and music computing.";71429;50000;H2020-SMEINST-1-2014;SME-1;VOCTRO LABS SL;ES;;; 194359;645684;Immuno-NanoDecoder;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins;1/04/2015;31/03/2019;;"The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells.
The Immuno-nanodecoder will be used for the accurate molecular characterization of skin cancer (melanoma) and glycogenosis type II cellular models and to evaluate the in vitro response to experimental therapies.
The nanodevices (nanodecoders) will consist of self-assembled DNA nanostructures that can reversibly change their fluorescence signal output in response to hybridization to nucleic acid sequences, or to a specific enzymatic reaction. Each nanodevice will be coupled to a specific molecular probe, such as an antibody, peptide, or protein that uniquely recognize disease biomarkers. The coupling will allow the nanodecoder to detect biomarker presence and distribution in cells and tissues, in a layer-by-layer fashion, using optical fluorescence microscopy.
The number of biomarkers that can be detected will be limited only by the capacity to design nanodecoders with differing specificities, which is essentially unlimited.
The creation of nanodecoders and optimization of their function will greatly advance biomarker imaging, which currently lacks a high-throughput, convenient method for the in situ, quantitative microscopic analysis of altered tissue regions.
This project will be driven by knowledge exchange and the expertise of an interdisciplinary team comprised of both early-stage and experienced university and hospital researchers.
Complementary research programs, ranging from nanotechnology to molecular medicine and pathology will support each step of the developmental and applicative parts of the project towards the achievement of its objectives.
Funding of this program will enable long-term, transformative collaborations that will contribute to the integration and collaboration of research groups between European Countries and key Third Countries.";441000;441000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA;IT;"UNIVERSITY OF LINCOLN;AZIENDA SANITARIA UNIVERSITARIA INTEGRATA DI UDINE";"UK;IT"; 194594;649594;EUth;SIGNED;H2020-EU.3.6.;YOUNG-5b-2014;H2020;EUth - Tools and Tips for Digital and Mobile Youth Participation in and across Europe;1/03/2015;28/02/2018;http://www.euth.net/;"With the experiences of 3 pilot projects and the expertise of 11 partners from 8 European countries, a digital European youth participation online platform will be built, which is tested and open to be used by administrations and youth organizations of any size and level to set up participative processes.
The platform consists of
comprehensive eParticipation package (EUth-applications), bringing together web online participation and mobile participation on a modular, adaptive basis. Foundation are the softwares Adhocracy and FlashPoll (developed in EIT/ICT Labs).
A modularized method-handbook (EUth-methods) made available in a digital decision-support-tool, giving practical support how to make optimum use of the applications features.
Country-specific guidelines (EUth-services) to take away fears and give advice on how to solve problems such as community management and online moderation, security etc.

The platform will be easy-to-use and perfectly user-adapted through participative product design in a living lab. Special focus is the evaluation of pilot projects using the platform:
The European youth organization AEGEE will improve its communication and discussion process with its members
In France, two institutions, the City of Paris and the French federation of community centers will foster youth empowerment and inclusion
In Italy and Slovenia a cross-border pilot will aim at guiding young community managers that will interact with their respective city administration

A sustainable impact is created through an innovation strategy which among other measures includes the deployment of the platform. Within an Open Call 10 European municipalities and local organizations are each given 10.000 to implement independent participation strategies on the online platform.
EUth will increase the trust of European youth in Europe and political institutions by making European youth participation more attractive for all involved actors and thus make it happen more frequently.";2932353,57;2579500;H2020-YOUNG-SOCIETY-2014;IA;NEXUS INSTITUT FUR KOOPERATIONS MANAGEMENT UND INTERDISZIPLINARE FORSCHUNG GMBH;DE;"IJAB FACHSTELLE FUER INTERNATIONALE JUGENDARBEIT DER BUNDESREPUBLIK DEUTSCHLAND e.V.;KUNGLIGA TEKNISKA HOEGSKOLAN;ASSOCIATION DES ETATS GENERAUX DES ETUDIANTS DE L'EUROPE;ISTITUTO DI STUDI PER L'INTEGRAZIONE DEI SISTEMI (I.S.I.S) - SOCIETA'COOPERATIVA;FONDEN TEKNOLOGIRADET;RAZVOJNI CENTER SRCA SLOVENIJE DOO;ALFSTORE SAS;LIQUID DEMOCRACY EV;AGENCE EUROPEENNE POUR L'INFORMATION ET LE CONSEIL DES JEUNES ASBL;MISSIONS PUBLIQUES";"DE;SE;BE;IT;DK;SI;FR;LU"; 194441;646456;GrowSmarter;SIGNED;H2020-EU.3.3.1.3.;SCC-01-2014;H2020;GrowSmarter;1/01/2015;31/12/2019;;"GrowSmarter aims to:
Improve the quality of life for European citizens by better mobility, housing and the quality of urban infrastructure while improving the citizens economy by lower energy costs and creating as much as 1500 new jobs (on the demonstration level).
Reduce the environmental impact by lower energy needs by 60 % and increased use of renewable energy thus reducing GHG emissions even more.
Create sustainable economic development by demonstrating and preparing a wider rollout of smart solutions.

GrowSmarter will demonstrate at 3 lighthouse cities 12 smart, integrated solutions as a way of preparing for a wider market rollout. These solutions are integrated in specially chosen sites making demonstration easy to reach and take part of for the 5 follower cities and other European and international study groups. All the smart solutions are fit into the Lighthouse-cities strategic development plans and the follower cities replication plans.

The solutions solve common urban challenges such as:
Renewal of existing buildings. GrowSmarter demonstrates the cost efficient renewal of 100.000 square meters of Nearly Zero or low energy districts reducing energy demand by 70-90%,
Integrated infrastructures for ICT, street lighting, smart grids district heating and smarter waste handling
Sustainable urban mobility for both passenger and gods integrated in smart grids, biofuels from household waste thus reducing local air quality emissions by 60%.

The integration of Cities, strong group of industrial partners together and quality research organisations guarantee that the solutions will be both validated by independent research organisations and transformed into Smart Business Solutions by industry for the wider rollout to Europe.

Growsmarter builds on integrated, close to the market solutions, to form business models for their wider deployment by the industrial partners. The project will help Europe GrowSmarter!";34560205,86;24820974,38;H2020-SCC-2014;IA;STOCKHOLMS STAD;SE;"STADT GRAZ;DALKIA SVERIGE AB;URBISUP CONSULTING SL;CAMARA MUNICIPAL DO PORTO;IBM SVENSKA AB;CONSORCI CENTRE D'INNOVACIO DEL TRANSPORT;AMPIDO GMBH;KUNGLIGA TEKNISKA HOEGSKOLAN;SKANSKA SVERIGE AB;RHEINENERGIE;ENDESA ENERGIA S.A.;CARRIER TRANSPORT AB;FUNDACIO INSTITUT DE RECERCA DE L'ENERGIA DE CATALUNYA;FORTUM SVERIGE AB;POLIS - PROMOTION OF OPERATIONAL LINKS WITH INTEGRATED SERVICES, ASSOCIATION INTERNATIONALE;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;AUTHORITY FOR TRANSPORT IN MALTA;SCHNEIDER ELECTRIC INDUSTRIES SAS;Philips GmbH;RETEVISION I, S.A.;ENVAC AB;FORTUM POWER AND HEAT AB;GAS NATURAL SDG SA;UNIVERSIDAD DE NAVARRA;ENDESA DISTRIBUCION ELECTRICA S.L;ANTEVERTI CONSULTING SL;Municipiul Suceava;STADT KOLN;DEUTSCHE WOHNUNGSGESELLSCHAFT MBH -DEWOG;TINGCORE AB;STATTAUTO KOELN GESELLSCHAFT FUER CAR SHARING MBH;ICLEI EUROPEAN SECRETARIAT GMBH (ICLEI EUROPASEKRETARIAT GMBH)*;INSTITUT MUNICIPAL D'INFORMATICA DE BARCELONA;REGIONAL ENVIRONMENTAL CENTER FOR CENTRAL AND EASTERN EUROPE -REC;ENDESA SA;AGT GROUP (R&D) GMBH;CORK CITY COUNCIL;INSERO AS;FUNDACIO PRIVADA I2CAT, INTERNET I INNOVACIO DIGITAL A CATALUNYA";"AT;SE;ES;PT;DE;BE;MT;FR;RO;HU;IE;DK"; 194443;646463;NETFFICIENT;SIGNED;H2020-EU.3.3.;LCE-08-2014;H2020;Energy and economic efficiency for todays smart communities through integrated multi storage technologies;1/01/2015;31/12/2018;;"The project will deploy and demonstrate local storage technologies which have reached TRL 5-6 in a real electrical grid, and will develop ICT tools to exploit the synergies between them, the smart grid and the citizens. The demonstration in this real environment will be driven by five use cases covering low voltage and medium voltage scenarios and a wide range of applications and functionalities. Viable business models will be defined for the cases, and proposal for changes in regulations will be made. Dissemination and exploitation activities will ensure these results drive market uptake of storage technologies.
The expected outcomes of the project are:
- An energy management system to be used by the energy companies to manage the energy of their associates storage devices.
- Control systems to integrate management and decision support tools that enable the integration of renewable generation, forecasting and storage systems into the smart-grid.
- Innovative storage solutions:
HESS (Hybrid Energy Storage System Ultracapacitors \ Li-ion batteries)
Second Life Electric Vehicle Batteries
Home Hybrid technologies (Ultracapacitors \ Li-ion batteries)
- Business models to allow easier deployment of energy storage technologies into the electricity market
- Proposed changes to regulators in the social and economic areas in order to lower barriers to the deployment of distributed storage for the defined use cases.
- Life Cycle Assessment / Life Cycle Cost of the storage systems used in the project
The project will achieve topic expected impacts and also environmental and socioeconomic impacts, like carbon emissions reduction and lowering the EU dependency of fossil fuels.
The project gives Energy Services Companies (ESCO) a main role in the deployment and exploitation of storage solutions. The consortium foresees the creation of an ESCO to exploit demonstrated business models after the project.
The consortium is designed to meet the requirements of this innovation action, with strong industrial members, innovative SMEs, research organizations, experts, DSO and a follower smart-city. This consortium is capable of bringing innovative technologies to socioeconomically viable solutions.";11404646,96;8993598,88;H2020-LCE-2014-3;IA;AYESA ADVANCED TECHNOLOGIES SA;ES;"WIRTSCHAFTSBETRIEBE DER STADT NORDSEEHEILBAD BORKUM GMBH;SCHNEIDER ELECTRIC GMBH;VANDENBORRE ENERGY SYSTEMS NV;ZIGOR RESEARCH & DEVELOPMENT AIE;CENTRO DI RICERCA, SVILUPPO E STUDI SUPERIORI IN SARDEGNA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;WIND INERTIA TECHNOLOGIES S.L;STEINBEIS INNOVATION GGMBH;UNIVERSITA DEGLI STUDI DI CAGLIARI;POWERTECH SYSTEMS;SWEREA IVF AB;WILLIAMS GRAND PRIX ENGINEERING LIMITED;AYUNTAMIENTO DE SANTANDER";"DE;BE;ES;IT;FR;SE;UK"; 194678;650690;MD-PACS;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;A new paradigm in medical imaging systems for hospitals, clinics and professionals in spite of their size;1/10/2014;31/03/2015;;"MD-PACS addresses the opportunity of providing a new product and business concept within the growing market for Medical Imaging Information Systems (which includes PACS and HISE). This market is estimated in 2,7 billion for 2014, with a 10% CAGR for the next years. Europe, together with North America account for over 60% of the world market.

The market is dominated by large players which impose costly contracts: their implementation and maintenance costs into an average-size hospital are estimated in 3M for a 10 years period. This represents about 2% of hospitals budget: savings could be allocated to quality of medical service. Furthermore, only medium and large hospitals can afford PACS and HISE.
Small hospitals, clinics and diagnostic freelancers are ignored by industry leaders. There is a clear market opportunity for offering a comprehensive PACS-HISE solution under a new cost-effective business model.

The goal of our project is to open and lead this market by reducing PACS and HISE costs for healthcare organizations by 65%.

MD-PACS, our flagship product, is a cost-effective and fully reliable PACS with embedded HISE for radiology, laboratory and cardiovascular specialties. Based on cloud computing and automation technologies, MD-PACS is able to cope the needs of hospitals and clinics of any size, under a coherent and cost-effective business model: 1) Costs are automatically adjusted depending of capacity needed 2) automated maintenance tasks cut significantly maintenance costs; 3) It integrates PACS and HISE functionalities into a single product.

We plan to undertake detailed studies for identifying key actions points for the internationalization and fine-tuning of MD-PACS to make it a global success, purposes of Phase 2, for which we estimate a total budget of 1M for 1 year. In Phase 3 we will focus in further private investment.";71429;50000;H2020-SMEINST-1-2014;SME-1;MEDICAL DEV SL;ES;;; 194316;645376;FLOBOT;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Floor Washing Robot for Professional Users;1/01/2015;31/12/2017;;"Industrial, commercial, civil and service premises, such as supermarkets and airports have huge floor surfaces to be cleaned daily and infra-daily.

These activities are time demanding in terms of human repetitive activities and take place at sundry times, not necessarily covering a work-shift duration; this depends on the kind of premise and available time slots as well as on the type of organisation. The floor washing activities are favourably suited for robotization.

Currently it does not exists a robot that satisfies the requirements of the professional users and cleaning services companies. Floor washing tasks are demanding under many aspects: autonomy of operation, navigation precision, safety with regards to humans and goods, interaction with the human cleaning personnel, cleaning operations on demand during opening hours, presence of multiple robots at the same time in the same building, optimization of paths, easy set-up of path and duties without reprogramming.

The project FLOBOT addresses these problems, integrating existing solutions and knowledge of the partners to produce a professional floor washing robot for wide area of industrial, civil and commercial premises. The work that will be caried out on production prototypes will be at TRL8.

The FLOBOT project derives requirements from professional users and implements four use case validations in real world operational environments: Supermarkets, Airport, Civil Buildings";4204713,75;3186473,75;H2020-ICT-2014-1;IA;CY.R.I.C CYPRUS RESEARCH AND INNOVATION CENTER LTD;CY;"FIMAP SPA;TECHNISCHE UNIVERSITAET WIEN;UNIVERSITY OF LINCOLN;ROBOSOFT Services Robots;S.S.C. SOCIETA' SVILUPPO COMMERCIALE;MANUTENCOOP FACILITY MANAGEMENT SPA;GROUPE SERVICES FRANCE;RIDGEBACK S.A.S. DI PAOLO BARATTINI & C.";"IT;AT;UK;FR"; 194390;645770;SmartHELMET;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Intersectoral Network for Innovation on Smart Thermal Solutions for Bicycle Helmets;1/03/2015;28/02/2019;;Bicycle helmets are a tremendously important asset against head injuries during accidents. However, their normal use is often associated with strong thermal discomfort due to the (thermally) insulating nature of the materials used in their structures. This affects directly the willingness to wear helmets, which has direct implications in terms of the risk to which riders are exposed to. However, the capacity and expertise to improve the thermal performance of helmets exist on academic institutions (e.g. expertise in thermal physiology, monitoring of bio-responses, active cooling) but they lack a viable supply chain to go from prototypes to finished products, ready for exploitation. On the other hand, SMEs lack the technical skills and research facilities to perform R&D activities, to solve the mentioned problem. To solve this intersectoral problem, the SmartHELMET project will create a sustainable ecosystem of collaboration and knowledge transfer between academic and industrial partners that will develop the next generation of bicycle helmets with smart thermal management. The projects innovative aspects in terms of new products, processes and applications are very significant, as the new knowledge has many potential applications in the development of other smart headgear products (e.g. motorcycle helmets, industrial protective headgear, sports related headgear, etc.) as well as smarts products in other sectors where the thermal aspect is crucial (e.g. protective garments, sports clothing and footwear). To achieve its objectives, SmartHELMET will put together research expertise and resources from three large academic partners with market, commercialization and innovation experience from three SMEs, to exchange knowledge through intersectoral staff secondments. The project will bridge research initiatives between the academic and industrial sectors, creating long-term cooperation between them, while raising society awareness about its implications for citizens.;1350000;1350000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSIDADE DO PORTO;PT;"CHRISTOS PAPADOPOULOS & SIA O.E.;CENTER FOR TECHNOLOGY RESEARCH AND INNOVATION LTD;LAZER SPORT NV;KATHOLIEKE UNIVERSITEIT LEUVEN;UNIVERSITE DE STRASBOURG";"EL;CY;BE;FR"; 194718;651263;ThinkEHR Platform;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;Think!EHR Platform as vendor-neutral, open health data platform, designed for real-time, transactional health data storage enabling to go from idea to application in one hour.;1/10/2014;28/02/2015;;"Governments, regions and healthcare organizations are beginning to realize that the real value of health IT is not in application but in data. Better data is a key to improving outcomes, managing chronic diseases, managing population health and must be kept and accessed for the lifetime of the patient.
Health IT vendors are developing monolithic healthcare applications covering all specialties with wide range of functionalities and proprietary health data models that were not designed for data outliving the application, making care coordination and lifelong health records difficult. Furthermore IT health data market is very competitive business environment, controlled by mega-vendors. Small companies and start-ups are facing severe difficulties when entering the market as these large corporations offer monolithic EHR solutions and lock-in their customers. Personalized IT solutions solving specific needs of health organisations are in these cases practically impossible to implement. Therefore it is not only necessary but critical to provide a vendor-neutral, big-data, high-performance platform designed to store,manage,query, retrieve and exchange structured electronic health record data based on open health data standards.
The Think!EHR Platform is based on open, community sourced clinical data models while providing the APIs and tools enabeling app developers to focus on innovation, new solution and easy clinical data management. Vendors relying on the platforms solid foundation, built in clinical data repository and the tools will benefit from reduced time to market and lower development costs.
With feasibility study we will verify the technological and economic viability of Think!EHR Platform as a product focusing on discovering technological and marketing bottlenecks and new opportunities. Based on outcomes we will prepare business plan with detailed marketing strategy for selected markets, described target stakeholders and approaches for each specific segment.";71429;50000;H2020-SMEINST-1-2014;SME-1;MARAND INZENIRING DOO;SI;;; 194393;645785;BLACK SEA HORIZON;SIGNED;H2020-EU.3.6.;INT-02-2014;H2020;Enhanced bi-regional STI cooperation between the EU and the Black Sea Region;1/02/2015;31/01/2018;;"BLACK SEA HORIZON has been designed to sustainably enhance bi-regional STI cooperation between the EU and the Black Sea region. The result of the projects STI dialogue support will be an improved knowledge base about EUs external environment and of the current framework for STI cooperation as well as an increased awareness to contribute to the elimination of remaining obstacles and to further intensify the bi-regional STI cooperation based on a jointly developed EU-Black Sea STI Cooperation Programme. To facilitate the pooling of resources the project will establish a group of committed funding parties, endowed with a functional call infrastructure and a clear set of rules and regulations, ready to implement a joint call for proposals. The participation of Black Sea researchers in HORIZON 2020 will be operationally facilitated through (i) identified common research topics taken-up in future calls for proposals, (ii) provision of up-to-date relevant information and good practices to participate in HORIZON 2020 to a large group of researchers, (iii) an increased number of joint research proposals through direct face-to-face meetings of, (iv) a young generation of social scientists trained in HORIZON 2020 and ready to promote and back up future RTI cooperation and (v) an increased readiness of programme owners both from the EU and Black Sea countries to engage jointly in JPIs and future COFUND ERA-NETs. Furthermore, the project will increase understanding of cluster policies and cluster management, establish direct business contacts between cluster managers from the EU and target countries and raise awareness on the programming of as well as on the advantages of inclusive, sustainable and social innovation.
The projects results will be broadly disseminated to increase awareness on bi-region STI cooperation activities and opportunities and will be exploited towards an enhanced introduction of the Black Sea region to the ERA.";1499503,75;1499503,75;H2020-INT-INCO-2014;CSA;ZENTRUM FUR SOZIALE INNOVATION GMBH;AT;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;STATE ORGANIZATION INSTITUTE FOR ECONOMICS AND FORECASTING UKRAINIAN NATIONAL ACADEMY OF SCIENCES;SHOTA RUSTAVELI NATIONAL SCIENCE FOUNDATION;NATIONAL ACADEMY OF SCIENCES OF THE REPUBLIC OF ARMENIA;CERISS - KENTRO PERIFEREIAKON KAI DIETHNON MELETON KAI YPOSTIRIXIS MONOPROSOPI IKE;INNO TSD;APPLIED RESEARCH AND COMMUNICATIONS FUND;SOCIEDADE PORTUGUESA DE INOVACAO - CONSULTADORIA EMPRESARIAL E FOMENTO DA INOVACAO S.A.;REGIONALIS INFORMACIOS ES FEJLESZTO TUDASKOZPONT KORLATOLT FELELOSSEGU TARSASAG;FEDERAL STATE AUTONOMOUS EDUCATIONAL INSTITUTION FOR HIGHER EDUCATION NATIONAL RESEARCH UNIVERSITY HIGHER SCHOOL OF ECONOMICS;INTERNATIONAL CENTER FOR BLACK SEA STUDIES;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;CENTRUL PROIECTE INTERNATIONALE;RUSSIAN FOUNDATION FOR BASIC RESEARCH;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;AZERBAYCAN RESPUBLIKASININ PREZIDENTI YANINDA ELMIN INKISAFI FONDU;ASOTSCIATSIA EVROPULI GAMOKVLEVEBI SAQARTVELOS INOVACIURI GANVITAREBISTVIS";"DE;UA;GE;AM;EL;FR;BG;PT;HU;RU;PL;MD;TR;RO;AZ"; 194427;646428;Flex4Grid;SIGNED;H2020-EU.3.3.4.;LCE-07-2014;H2020;Prosumer Flexibility Services for Smart Grid Management;1/01/2015;31/12/2017;;"The advent of distributed power sources, such as photovoltaics and windmill plants, gave rise to energy prosumers (producers-consumers), which generate and consume electrical energy. Energy demand and energy generation by prosumers are volatile and can impact the grid infrastructure and stakeholders, but they can be flexibly adapted to thwart those impacts.
Flex4Grid aims at creating an open data and service framework that enables a novel concept of managing flexibility of prosumer demand and generation, utilising cloud computing for power grid management and, opening DSO infrastructure for aggregator services. The system will be built up from existing ICT components developed by the consortium partners over many years in research projects on IoT and Cloud computing. This high maturity allows Flex4Grid to aim for a system prototype of TRL 7 which guarantees a maximum impact and competitiveness in the area of the smart grid challenge.
The Flex4Grid system will include a) a data cloud service with anonymised interface and advanced security and privacy mechanisms for data exchange and service management, b) prosumer generation and demand flexibility, and c) a more viable business model to accelerate the deployment. The major innovations are a) opening the market for new entrants by secure and privacy enabling third party cloud data and energy management services, b) actionable common and multilevel data management and analytics services for Smart Grids, and c) the use of co-creation to bring end users into the value creation process.
System validation will be carried out in real-world pilots in three live electricity networks with different scenarios ranging from deployment during smart meter rollout and retrofitting to large scale operation and federated demonstration of multi-site pilots.";3147871,25;2680253;H2020-LCE-2014-3;IA;TEKNOLOGIAN TUTKIMUSKESKUS VTT;FI;"INSTITUT JOZEF STEFAN;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;BOCHOLTER ENERGIE UND WASSERVERSORGUNG GMBH;SAE-AUTOMATION, S.R.O;ELEKTRO CELJE D.D.;ENERGIE- UND WASSERVERSORGUNG BONN/RHEIN-SIEG GMBH;SMART COM DOO INFORMACIJSKI IN KOMUNIKACIJSKI SISTEMI";"SI;DE;SK"; 194582;649447;RE-InVEST;SIGNED;H2020-EU.3.6.;EURO-3-2014;H2020;Rebuilding an Inclusive, Value-based Europe of Solidarity and Trust through Social Investments;1/03/2015;28/02/2019;;"In 2013, as a response to rising inequalities, poverty and distrust in the EU, the Commission launched a major endeavour to rebalance economic and social policies with the Social Investment Package (SIP). RE-InVEST aims to strengthen the philosophical, institutional and empirical underpinnings of the SIP, based on social investment in human rights and capabilities. Our consortium is embedded in the Alliances to Fight Poverty. We will actively involve European citizens severely affected by the crisis in the co-construction of a more powerful and effective social investment agenda with policy recommendations. This translates into the following specific objectives:
1. Development of innovative methodological tools for participative research, involving mixed teams of researchers, NGO workers and people from vulnerable groups in the co-construction of knowledge on social policy issues;
2. Diagnosis of the social damage of the crisis in terms of (erosion of) human rights, social (dis)investment, loss of (collective) capabilities;
3. Analysis of the relationships between the rise of poverty and social exclusion, the decline of social cohesion and trust, and the threats to democracy and solidarity in the EU;
4. Development of a theoretical model of social investment, with a focus on the promotion of human rights and capabilities;
5. Application of this model to active labour market policies and social protection: evaluation of policy innovations through qualitative and quantitative analyses;
6. Application of the same model to public intervention in five selected basic service markets: water provision, housing, early childhood education, health care and financial services, through qualitative and quantitative analyses;
7. Analysis of the macro-level boundary conditions for successful implementation of the SIP;
8. Capacity building in civil society organisations for the promotion of the European social investment agenda, through networking and policy recommendations.";2739600;2499600;H2020-EURO-SOCIETY-2014;RIA;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;"LIVERPOOL HOPE UNIVERSITY;OBSERVATOIRE SOCIAL EUROPEEN ASBL;FUNDATIA THE OPEN NETWORK FOR COMMUNITY DEVELOPMENT;REDE EUROPEIA ANTI POBREZA PORTUGAL ASSOCIACAO;NATIONAL UNIVERSITY OF IRELAND MAYNOOTH;INTERNATIONALES FORSCHUNGSZENTRUM FUER SOZIALE UND ETHISCHE FRAGEN;BEWEGING;RIGAS STRADINA UNIVERSITATE;THE POVERTY ALLIANCE;UNIVERSITE CATHOLIQUE DE LOUVAIN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;TECHNISCHE UNIVERSITEIT DELFT;LOUGHBOROUGH UNIVERSITY;COORDINAMENTO NAZIONALE COMUNITA DI ACCOGLIENZA ASSOCIAZIONE;UNIVERSITE DE GENEVE;ERASMUS UNIVERSITEIT ROTTERDAM;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;Soziologisches Forschungsinstitut Goettingen (SOFI) e.V.";"UK;BE;RO;PT;IE;AT;LV;FR;NL;IT;CH;DE"; 194454;646554;PV FINANCING;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-04-2014;H2020;PV FINANCING;1/01/2015;30/06/2017;;"Feed-in tariffs (FITs) have been the fuel for successful solar PV growth stories in basically every one of todays large solar markets. First in Europe, now in China and Japan. The US is the only exception backed by tax credits and net-metering, leasing has become a key means of financing residential solar systems there.
With many European countries phasing out FITs, the simplicity of selling solar power will be gone; and without safe and fair returns, real estate and homeowners will not invest in PV anymore. In post-FIT times, solar companies and/or electric utilities in partnership with financial institutions will have to come up with new business models and financing schemes for PV investors in order to continue the success story of the FIT era.
The German Solar Industry Association as project coordinator is driven by the mission to successfully evolve those business and financing models, to disseminate them among stakeholders and to shape the necessary policy framework and to remove barriers that prevent those models from realization.
Consequently, the goal of PV Financing is to help stakeholders from specific application segments with the implementation of PV projects based on new PV business models while applying innovative equity and debt financing schemes. The availability of financing for PV projects based on the new business models shall be increased and the transaction costs shall be decreased by educating investors, commercial banks and insurance companies on the PV business models and their risks.";2050938,75;2050938,75;H2020-LCE-2014-3;CSA;BSW - BUNDESVERBAND SOLARWIRTSCHAFT E.V.;DE;"COMITE EUROPEEN DE COORDINATION DE L'HABITAT SOCIAL AISBL;Ambiente Italia s.r.l.;ECLAREON GMBH;FRANKFURT SCHOOL OF FINANCE & MANAGEMENT GEMEINNUTZIGE GMBH;RESCOOP EU ASBL;OBSERVATOIRE ENERGIE RENOUVELABLES;ALLIANZ CLIMATE SOLUTIONS GmbH;PHOTOVOLTAIK AUSTRIA BUNDESVERBANDVEREIN;EPIA SOLARPOWER EUROPE AISBL;CREARA CONSULTORES SL;SOLAR TRADE ASSOCIATION LIMITED;ULUSLARARASI GUNES ENERJISI TOPLULUGU TURKIYE BOLUMU DERNEGI";"BE;IT;DE;FR;AT;ES;UK;TR"; 194663;650476;SmartPatch;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.7.";DRS-17-2014-1;H2020;Use of a cost effective smart skin sensor system for remote Structural Health Monitoring and post event structural damage assessment in Soft Urban Targets and Critical Infrastructures Protection;1/07/2014;31/12/2014;;"Analysis and testing of our Smart Skin Sensor System for remote Structural Health Monitoring in the ambit of remote and real time Post Event Damage Assessment. We intend to proof the value of our Sensor System in case of a disastrous event (so as terroristic attack, explosion or earthquake) causing damage to Soft Urban Targets and Critical Infrastructures so as bridges or tunnels, towers and buildings.
The Sensor System is composed by, embedded between two layers of impregnable fabric, a strain gauge made of conductive fibre and a system on chip able to transmit the measured values in RFID to the external reader and from there via Mesh Network to a central router and then to server for data elaboration. The single sensors has a minimum size of Din-A-4 paper sheet.
The sensor is able to detect damage before it reaches a critical state and allows rapid post-event assessment, e.g. after an explosion. The actual state of art in the Structural Health Monitoring involves very expensive technologies like fibre grating and extensive visual control and nondestructive testing through specialized personnel. Our Sensor System is much more cost effective and much easier to implement. Once applied, it becomes an integral part of the structure to be controlled. The system is able to integrate further sensors like thermometer, accelerometer, tilt sensor, in case needed.
Several very critical technical challenges are overcome and protected by two patent applications to be extended into PCT, more to follow, as the development points versus the possibility to eliminate the system on chip in a future version by using different material.
As several commercial pre contacts resulted very positive, particularly with a leading European cement supplier and a leading global supplier of advanced composite structures, an acceleration of the time-to-market is critical.";71429;50000;H2020-SMEINST-1-2014;SME-1;SMARTPATCH SRLS;IT;;; 194426;646397;NANOLEAP;SIGNED;H2020-EU.2.1.2.4.;NMP-01-2014;H2020;Nanocomposite for building constructions and civil infraestructures: European network pilot production line to promote industrial application cases.;1/01/2015;30/06/2018;;"NANOLEAP project aims at the development of a coordinated network of specialized pilot lines for the production of nanocomposite based products for different civil infrastructure and building applications.
The goal of this infrastructure is to support the research activities of European SMEs in the Construction sector in nanocomposite products enabling the progress of the product to next steps of technology deployment such as installation of industrial pilot lines and enter in the commercialization stage.
For the creation of the NANOLEAP project pilot line network, the most promising applications of polymeric nanocomposites in the construction and engineering sector have been selected. This project will support the pilot lines for the scaling up and production of these nanocomposite based products in order to facilitate their further adoption by the entire construction chain:
Antiweathering and anticorrosion nanocomposite coatings for the protection of structures exposed to aggressive environments such as wind turbines, offshore, marine infrastructure.
Multifunctional polymeric nanocomposites providing smart applications to traditional construction materials such as concrete and coatings including self-cleaning, hydrophobicity, optical properties, early warning crack and water leak alarm.
Prefab non-structural elements such as aerogels mechanically reinforced with nanoparticles for high-thermal insulation applications in building insulation.
Coated nanoparticles with improved compatibility with the matrix providing a wide range of functionalities and leading to high quality products and important saves of energy.
In order to implement and demonstrate this approach, NANOLEAP project brings together a European Network of pilot production facilities focused on scaling up nanocomposite synthesis and processing methods.";7679159,25;6878348,75;H2020-NMP-PILOTS-2014;RIA;UNIVERSIDAD DE CASTILLA - LA MANCHA;ES;"COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;SWEREA SICOMP AB;NANTO CLEANTECH SPA;INEA INFORMATIZACIJA ENERGETIKA AVTOMATIZACIJA DOO;D'APPOLONIA SPA;GRAPHENANO SL;PURINOVA Sp. z o.o.;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;NETCOMPOSITES LIMITED;SEPAREX SAS;LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV;FUNDACION IMDEA NANOCIENCIA;CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD;CENTRO EUROPEO PER I POLIMERI NANOSTRUTTURATI SCARL;STAMTECH SRL;EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT;ACCIONA CONSTRUCCION SA";"FR;SE;IT;SI;ES;PL;DE;UK;CH"; 194459;646578;Triangulum;SIGNED;H2020-EU.3.3.1.3.;SCC-01-2014;H2020;Triangulum: The Three Point Project / Demonstrate. Disseminate. Replicate.;1/02/2015;31/01/2020;;"The Triangulum project will demonstrate how a systems innovation approach based around the European Commissions SCC Strategic Implementation Plan can drive dynamic smart city development. We will test the SIP across three lighthouse cities: Manchester, Eindhoven and Stavanger, which represent the main typologies of European cities. They will be complemented by our follower cities Prague, Leipzig and Sabadell. This powerful combination reflects an urban population of between 100k and 1,2m inhabitants across six different countries, allowing us to demonstrate successful replication across a wide range of typical urban areas in Europe. Each city has already made significant progress towards the transition of becoming a smart city; developing their own individual approach reflecting specific local circumstances. These inherent strengths will now serve to accelerate the smart city development across proposed demonstration sites within Triangulum. The suite of projects developed will be based around zero/low energy districts, integrated infrastructures and sustainable urban mobility designed to deliver a range of cross-cutting outcomes across different sectors and stakeholders. This will provide the basis to road test the SIP and provide recommendations to the Commission on how it could be improved to facilitate wider replication. The Triangulum goals target a series of direct impacts around; reduced energy consumption of buildings, increased use of renewable energies, increased utilisation of electric vehicles, deployment of intelligent energy management technologies and the deployment of an adaptive and dynamic ICT data hub. The design and implementation of innovative Business Models and the activation of citizens as co-creators are core cross-cutting elements to base the technologies in real-world city environments and facilitate replication.";29501430,98;25420602,3;H2020-SCC-2014;IA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"STRIJP S ONTWIKKELING BV;INSTITUT PLANOVANI A ROZVOJE HLAVNIHO MESTA PRAHY;STICHTING WOONBEDRIJF SWS HHVL;THE UNIVERSITY OF MANCHESTER;AJUNTAMENT DE SABADELL;THE MANCHESTER METROPOLITAN UNIVERSITY;GEMEENTE EINDHOVEN;STEINBEIS INNOVATION GGMBH;SIEMENS PLC;LYSE AS;UNIVERSITETET I STAVANGER;STADT LEIPZIG;CLICKS AND LINKS LTD;Stavanger kommune;Universitaet Stuttgart;TECHNISCHE UNIVERSITEIT EINDHOVEN;GREATER STAVANGER ECONOMIC DEVELOPMENT AS;Koninklijke KPN NV;ROGALAND FYLKESKOMMUNE;TUV SUD IMMOWERT GMBH;MANCHESTER CITY COUNCIL";"NL;CZ;UK;ES;DE;NO"; 194344;645642;REC;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Root zone soil moisture Estimates at the daily and agricultural parcel scales for Crop irrigation management and water use impact a multi-sensor remote sensing approach;1/03/2015;28/02/2019;;"Sustainable water use is a growing concern in Europe. Nowadays, agriculture is an important pressure on water resources especially in Mediterranean countries where irrigation can represent up to 80% of the consumptive uses of water. Increasing water use efficiency in agriculture has been thus identified as one of the key themes relating to water scarcity and drought (EEA Report No 1/2012). It now becomes necessary to improve on-farm irrigation management by adjusting irrigation to crop water requirements along the growing season.

Modern irrigation agencies rely on in situ root zone soil moisture measurements to detect the onset of crop water stress and to trigger irrigation. However, in situ point measurements are generally not available over extended areas and may not be representative at the field scale. If remote sensing provides cost-effective techniques for monitoring broad areas, there is currently no algorithm dedicated to root zone soil moisture monitoring at the parcel scale.

REC proposes a solution to the need of root-zone soil moisture at the crop scale for irrigation management. It is based on an innovative operational algorithm that will allow for the first time to: 1) to map root zone soil moisture on a daily basis at the field scale and 2) to quantitatively evaluate the different components of the water budget at the field scale from readily available remote sensing data.

The methodology relies on the coupling between a surface model representing the water fluxes at the land surface atmosphere interface (infiltration, evaporation, transpiration) and in the soil (drainage), and remote sensing data composed of land surface temperature, and near-surface soil moisture retrieved from microwave radiometers and radars.

These estimates will be integrated in an irrigation management system that will be used to trigger irrigation. In addition, these estimates will allow making an impact assessment of the consumptive use of water and water footprint.";895500;895500;H2020-MSCA-RISE-2014;MSCA-RISE;ISARDSAT SL;ES;"UNIVERSITE PAUL SABATIER TOULOUSE III;CENTRO DE ASESORIA DOCTOR FERRER SL;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT";"FR;ES"; 194703;650759;CVDTEU;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;Clinical validation of the DiviTum assay in key European markets;1/11/2014;28/02/2015;;Many cancer therapies fail due to inadequate prediction of patient-specific treatment responses. In addition, a large number of clinical trials fail due to a lack of predictive tools for optimal cohort selection. Biovica has developed a sensitive and precise assay for the measurement of a biomarker thymidine kinase (TK) from serum as an indicator of cell proliferation. Our assay technology has been clinically tested and has demonstrated beyond state-of-the-art capability compared to existing solutions due to its unprecedented sensitivity. This allows for previously unrealized capabilities in monitoring and prediction of therapy response for most common cancers. The unique selling point of our technology is the documented ability to reliably measure solid tumor proliferation from serum, thereby making it cheaper, more scalable and less invasive for the patient than industry standards. Our key customers are drug developers and clinicians who will use it for optimal cohort selection for clinical trials, and prediction of treatment response for patients respectively. However, in order to reach these customers, we require carrying out extensive clinical validations to demonstrate technological soundness. Europe represents the largest market for biomarker diagnostics due to a growing ageing population. We therefore aim to conduct clinical studies in key European markets with access to relevant bio-banks. In phase 1 of the proposed project, we will perform a feasibility study with focus on market related activities in Europe. Thereafter we aim to conduct clinical studies in selected European countries in partnership with clinicians. Our ambition is to become the industry standard for cancer proliferation measurement worldwide.;71429;50000;H2020-SMEINST-1-2014;SME-1;BIOVICA INTERNATIONAL AB;SE;;; 194301;645244;EuDEco;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;Modelling the European data economy;1/02/2015;31/01/2018;;"The Modelling the European Data Economy (EuDEco) project will assist European sci-ence and industry in understanding and exploiting the potentials of data reuse in the context of Big and Open Data big data. The aim isto establish a self sustaining data market and thereby increase the competitiveness of Europe. To be able to extract the benefits of data reuse, it is crucial to know how to understand the underlying economic, societal, legal, and technological framework conditions and challenges to build useful applications and services. Despite the amount of activities in this domain, an effort is missing to develop use cases and business models that are economic viable, legally certain and taking societal needs and concerns into account.

EuDEco will accomplish this by leveraging the engagement of other projects conducting pilots on data reuse as well as by the engagement of external experts and stakeholders. EuDEco moves beyond the classical approaches by applying the approach of complex adaptive systems to model the data economy in order to indentify value networks, use cases and business models for data reuse. In the course of the project will develop and refine the data economy model in several steps further by case studies on previous pilots on data reuse, by in-depth analysis from legal, socioeconomic and technological point of view, and by extensive tests of use cases and business models with other projects. Therefore it will analyse framework conditions relevant and challenges related to data reuse and the emergence of a self-sustaining data market.

Finally, EuDEco will deliver a model of the data economy including viable use cases and business models as well as suggestions and recommendations addressing the main legal, contractual, societal, and technological concerns and challenges such as contractual framework or data protection. Above that EuDEco will develop an observatory for policy makers enabling them to track the development of the data economy.";2276625;2276625;H2020-ICT-2014-1;CSA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"ASCORA GMBH;SIGMA ORIONIS SA;ROOTER ANALYSIS SL;INFORMATIKAI TAVKOZLESI ES ELEKTRONIKAI VALLALKOZASOK SZOVETSEGE EGYESULET;UNIVERSITEIT LEIDEN";"DE;FR;ES;HU;NL"; 194375;645736;EVE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;INNOVATIVE ENGINEERING OF GROUND VEHICLES WITH INTEGRATED ACTIVE CHASSIS SYSTEMS;1/01/2015;31/12/2017;;Innovation technologies in ground vehicle engineering require strong interdisciplinary and intersectoral investigations with an international dimension. In this context the project EVE proposes sustainable approach based on intensive staff exchange that leads to collaborative research and training between universities and industrial organizations from Germany, Belgium, Spain, Sweden, The Netherlands, South Africa, and the USA. The project includes basic and applied research, development design, experimentations, networking, and dissemination and exploitation activities. The research objectives are focused on the development of (i) experimental tyre database that can be used in the design of new chassis control systems and subjected to inclusion into Horizon 2020 pilot on Open Research Data, (ii) advanced models of ground vehicles and automotive subsystems for real-time applications, and (iii) novel integrated chassis control methods. It will lead to development and improvement of innovative vehicle components such as (i) an integrated chassis controller targeting simultaneous improvements in safety, energy efficiency and driving comfort, (ii) new hardware subsystems for brakes, active suspension and tyre pressure control for on-road and off-road mobility, and (iii) remote network-distributed vehicle testing technology for integrated chassis systems. The project targets will be achieved with intensive networking measures covering (i) knowledge transfer and experience sharing between participants from academic and non-academic sectors and (ii) professional advancement of the consortium members through intersectoral and international collaboration and secondments. The project EVE is fully consistent with the targets of H2020-MSCA-RISE programme and will provide excellent opportunities for personal career development of staff and will lead to creation of a strong European and international research group to create new hi-tech ground vehicle systems.;616500;571500;H2020-MSCA-RISE-2014;MSCA-RISE;TECHNISCHE UNIVERSITAET ILMENAU;DE;"DSPACE DIGITAL SIGNAL PROCESSING AND CONTROL ENGINEERING GMBH;TENNECO AUTOMOTIVE EUROPE BVBA;SKF BV;CHALMERS TEKNISKA HOEGSKOLA AB;UNIVERSITY OF SURREY;INSTITUTO TECNOLOGICO DE ARAGON;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;TECHNISCHE UNIVERSITEIT DELFT;UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE;AKTIEBOLAGET SKF";"DE;BE;NL;SE;UK;ES;FR"; 194569;649266;SET IT;SIGNED;"H2020-EU.3.3.;H2020-EC";Energy75;H2020;Organization and Delivery of the Italian Presidency Conference on the European Strategic Energy Technology Plan (SET-Plan) the SET IT Project;1/07/2014;31/12/2014;;"The Seventh SET-Plan Conference will be aimed at i) providing a privileged forum for open discussions to develop a new integrated vision for the SET Plan and shared understanding; ii) providing stakeholders with an updated panorama of the European energy and technology framework policies as groundwork for spurring active participation and commitment to the SET Plan objectives; and iii) outreaching the SET Plan current portfolio, that is to address still untapped resources of relevant sectors.
The SET IT project covers all aspects of planning and delivering the SET Plan Conference, including the development of crucial accompanying activities such as an integrated awareness and dissemination campaign to enlarge audience from stakeholder groups to civil society, and enhance the Conference impacts. A special governance scheme has been conceived so as to create a synergy among political decision makers, the different stakeholder groups, and the communication experts and consultants involved in the conference organization and promotion. The exploitation of 2.0 technology will also contribute to the creation of a favorable environment for updated policy dialogues, strategic thinking, networking and dissemination; data and materials (i.e. social network pages) produced will outlast the project itself and will be passed on to future SET Plan Conference organizers. Thereby, the SET IT project will first provide a basis for creating a linkage connecting future SET Plan Conferences as part of a greater, lasting effort toward policy integration, building up experience and networking results, thus overcoming a typical weakness of such events, which are short-lived although quite expensive and labour intensive.";350000;262500;H2020-Adhoc-2014-20;CSA;AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE;IT;;; 194386;645760;DOMINO;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Design Oriented ModellINg for flexible electrOnics;1/12/2014;30/11/2018;;Our project aims to fill the gap between flexible electronic technology and design by developing highly predictive, generic, open-source, design-oriented organic and oxide based TFT compact model libraries, to be integrated in commercial Electron Design Automation (EDA) environments for full large area low cost circuit design for novel applications. These model libraries will be released together with parameter extraction standard templates to assist in the fast transfer between initial prototype device measurements to full product design. Such a facility will open the opportunity for wide flexible electronics design;742500;742500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITAT ROVIRA I VIRGILI;ES;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;SILVACO EUROPE LTD;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;INFINISCALE SA;ADMOS GMBH ADVANCED MODELING SOLUTIONS;ECOLE POLYTECHNIQUE;TECHNISCHE HOCHSCHULE MITTELHESSEN";"UK;NL;FR;DE"; 194648;650194;OTR;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Off The Rails;1/10/2014;28/02/2015;;"Off the Rails is a concept to develop a mobile application that intelligently understands user movement patterns, not just in terms of location, speed and transport mode. Utilising smart-phone sensors, GPS mapping and game mechanics, it will give the user the vectored detail of their daily travels.
The unique concept is being developed in the context of Mudlarks world-leading digital public transport game, Chromaroma, which turns all swipes of a players London travel smartcard into gameplays and achievements, promoting sustainable transport use by encouraging non-rush hour travel.
The advent and increasing accuracy of geolocation data harnessed with the prevalence of powerful personal mobile devices means we use OTR to make the individual traveller a transport integrator. We can build a platform that attracts these solo integrators and retains them by improving their travel experience, at the same time capturing individual journey data. That platform can then flip the transport integration problem by addressing it from the user level up.
By combining and transferring new and existing knowledge into an innovative, disruptive and competitive solution, we will enhance the profitability and growth performance of Mudlark (an SME). We need the funding from this grant to help seize the European and global business opportunity.
As well furthering our understanding the commercial case, our project objectives are to:
? Discover and understand the user needs. This will culminate in a framework and design scoping document.
? Test initial technical and tracking assumptions with an end-user group.
? Design the user experience and game using screen and paper prototypes.
? Produce a detailed report, game design document and business planning roadmap.
We will conduct a variety of analyses to confirm the viability of our game and justify further external investment, specifically
Phase 2 funding from this programme.";71429;50000;H2020-SMEINST-1-2014;SME-1;THE MUDLARK PRODUCTION COMPANY LIMITED;UK;;; 194428;646435;CrowdFundRES;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-04-2014;H2020;Unleashing the potential of Crowdfunding for Financing Renewable Energy Projects;1/02/2015;31/01/2018;;"We are currently seeing a deceleration of renewable energy growth in Europe. This is partly attributed to the challenges for financing renewable energy projects. Reduced access to conventional financing options over the past few years has triggered innovative financing schemes to emerge, with crowdfunding attracting a lot of attention.

CrowdFundRES recognises the vast potential of crowdfunding for financing renewable energy projects. The project has been developed for and in cooperation with the three target groups:
1) Renewable energy project developers whose access to financing is getting more challenging
2) The part of the public that has an interest in investing even very small amounts of their savings in renewable energy projects
3) Crowdfunding platforms who act as intermediaries facilitating the financial transaction between the public and the project developers.

The overall objective of the proposed project is to contribute to the acceleration of the renewable energy growth in Europe by unleashing the potential of crowdfunding for financing renewable energy projects. In order to achieve this, the work has been structured for achieving the following objectives:
1. Gain a deep understanding of the publics perception of crowdfunding
2. Analyse the challenges faced by the application of crowdfunding for renewable energy projects in Europe
3. Develop guidelines that support easier, more effective and wider accepted practices in crowdfunding renewable energy projects
4. Apply the guidelines and review them based on practical experience
5. Improve the market and regulatory framework
6. Promote the crowdfunding concept and its advantages among those who could contribute or raise funds";1994915;1893002,5;H2020-LCE-2014-3;CSA;WIRTSCHAFT UND INFRASTRUKTUR GMBH & CO PLANUNGS KG;DE;"VALOREM SAS;OSBORNE CLARKE ANWALTSSOZIETAT;University of Dundee;YOURIS.COM;EUROPEAN CROWDFUNFIND NETWORK;Abundance NRG Ltd;STICHTING ONE PLANET CROWD NEDERLAND;EPIA SOLARPOWER EUROPE AISBL;BNRG RENEWABLES LIMITED;GREEN CROWDING GMBH;ASSOCIATION EUROPEENNE DE LA PETITE HYDRAULIQUE AISBL;LUMO;GLOBAL 2000 UMWELTSCHUTZORGANISATION;RENEWABLE ENERGY GENERATION LIMITED;ONEPLANETCROWD INTERNATIONAL BV";"FR;DE;UK;BE;NL;IE;AT;JE"; 194380;645751;RISE_BPM;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Propelling Business Process Management by Research and Innovation Staff Exchange;1/05/2015;30/04/2019;;"RISE_BPM networks world-leading research institutions and corporate innovators to develop new horizons for Business Process Management (BPM). BPM is a boundary-spanning discipline focused on division and re-integration of day-to-day work in organisations and on analysis of process data for organisational decision-making. Recent break-through innovations in Social Computing, Smart Devices, Real-Time Computing, and Big Data Technology create a strong impetus for propelling BPM into a pervasive corporate topic that enables design of entirely new products and services.
All RISE_BPM consortium members possess excellent expertise in distinct aspects of the BPM lifecycle, ranging from Strategy and Modelling to Implementation and Analysis of business processes. RISE_BPM networks this complementary knowledge to create a unique environment for BPM research and innovation. The research activities are organised with reference to the design-science paradigm, including joint activities for analysing technological enablers and societal impact factors, as well as designing innovative IT artefacts for the BPM lifecycle.
Staff secondments and joint events promote a cumulative exchange of knowledge in a think-pair-square-share approach that networks large-scale research capabilities and innovation projects carried out by the involved organisations. Key objectives of RISE_BPM are (a) to propel BPM research into the era of Social Computing, Smart Devices, Real-Time Computing, and Big Data Technology; (b) to enable companies to develop new products and services for designing and analysing business processes; and (c) to supply the involved staff with a unique intellectual environment for accumulating boundary-spanning knowledge and skills that refer to the entire BPM lifecycle.
RISE_BPM extends the established administrative structures of the European Research Center for Information Systems (ERCIS) by involving additional BPM thought leaders and corporate innovators.";855000;855000;H2020-MSCA-RISE-2014;MSCA-RISE;WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER;DE;"WIRTSCHAFTSUNIVERSITAT WIEN;UNIVERSIDAD DE SEVILLA;TECHNISCHE UNIVERSITEIT EINDHOVEN";"AT;ES;NL"; 194552;648982;STERCP;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Synchronisation to enhance reliability of climate predictions;1/09/2015;31/08/2020;;"Climate prediction is the next frontier in climate research. Prediction of climate on timescales from a season to a decade has shown progress, but beyond the ocean skill remains low. And while the historical evolution of climate at global scales can be reasonably simulated, agreement at a regional level is limited and large uncertainties exist in future climate change. These large uncertainties pose a major challenge to those providing climate services and to informing policy makers.

This proposal aims to investigate the potential of an innovative technique to reduce model systematic error, and hence to improve climate prediction skill and reduce uncertainties in future climate projections. The current practice to account for model systematic error, as for example adopted by the Intergovernmental Panel on Climate Change, is to perform simulations with ensembles of different models. This leads to more reliable predictions, and to a better representation of climate. Instead of running models independently, we propose to connect the different models in manner that they synchronise and errors compensate, thus leading to a model superior to any of the individual models a super model.

The concept stems from theoretical non-dynamics and relies on advanced machine learning algorithms. Its application to climate modelling has been rudimentary. Nevertheless, our initial results show it holds great promise for improving climate prediction. To achieve even greater gains, we will extend the approach to allow greater connectivity among multiple complex climate models to create a true super climate model. We will assess the approachs potential to enhance seasonal-to-decadal prediction, focusing on the Tropical Pacific and North Atlantic, and to reduce uncertainties in climate projections. Importantly, this work will improve our understanding of climate, as well as how systematic model errors impact prediction skill and contribute to climate change uncertainties.";1999388,75;1999388,75;ERC-2014-CoG;ERC-COG;UNIVERSITETET I BERGEN;NO;;; 194412;646107;EU-GREAT;SIGNED;H2020-EU.2.1.3.;NMP-37-2014;H2020;European guide and recommendations for the combined funding of large-scale RDI initiatives;1/01/2015;31/12/2016;;"The rationale for EU-GREAT originates from the observation that more budget is needed and public and private sectors must join forces to increase the number of large-scale RDI initiatives in Europe, in order to ultimately boost the commercialisation of new technologies, products and services able to strengthen the competitive-edge of the European Industry while, at the same time, solve Europes societal challenges.
The overall objective of the project is to identify the key issues required to combine different funding mechanisms and support the scale up of research into market through large scale RDI initiatives. The expected impact of the project is to provide guidelines and initiate the development of RDI initiatives that combine different funding mechanisms. This will be facilitated with:
1. Identification of the key issues that are hindering setting up investment plans for large scale RDI initiatives.
2. Creating an overview of public as well as private investment sources.
3. Assessment of the (miss)match between demand and supply of funding.
4. Hands-on analysis and elaboration of concrete plans for investment, for at least 4 typical cases.
5. Manuals for (consortia of) organizations on how to create combined funding schemes for large RDI projects focusing on pilot production.
6. Recommendations for policy representatives on how to create and align combined funding schemes.
7. Raise awareness and knowledge among industrial players, policy-makers and other actors engaged in large-scale RDI initiatives on the problems and solutions to combining funding from different public and private sources.
EU-GREAT! consortium is a strong mix of research, industry and public authorities key to any innovation value chain. The success of EU-GREAT! is based upon the ability of the consortium as a whole to engage stakeholders in the project as well as their experience in establishing and operating large-scale RDI initiatives.";991325;991325;H2020-NMP-CSA-2014;CSA;FUNDACION TECNALIA RESEARCH & INNOVATION;ES;"POLITECHNIKA WROCLAWSKA;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;PLASTIQUES RG SAS;NANOFUTURES ASBL;HIGH VALUE MANUFACTURING CATAPULT;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;ARCELORMITTAL BELGIUM NV;TEKNOLOGIAN TUTKIMUSKESKUS VTT;Teknologian tutkimuskeskus VTT Oy";"PL;NL;FR;PT;BE;UK;ES;FI"; 194371;645717;PROTINUS;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;PROviding new insighT into INteractions between soil fUnctions and Structure;1/01/2015;31/12/2018;;"The PROTINUS proposal assembles a multi-disciplinary team to combine advanced, applied and theoretical research to create a new standard in imaging, analysing, modelling and predicting the interactions between soil structure and soil functions. Soil structure impacts a whole range of services soil renders to ecosystems, including for example contaminant filtering, carbon storage, root growth, and microbiological diversity.

By using modern imaging, image analysis and modelling techniques, we will develop an integrated approach to perform experiments in soil physics, bio-chemistry, to reconstruct soil structure in 3D and to model soil processes. The evaluated models will be used for predicting the different services soil renders to ecosystems in a dynamic way and for testing classical theory, where soil structure is not directly taken into account. To do so we will bring together the theoretical and practical expertise of the involved researchers, infrastructure of the partnering institutes, soil samples and databases.

The first stage will investigate todays best practise in experimental soil science and imaging, data analysis and modelling. Our findings will enable our second stage approach where synergies between the different disciplines will be explored. The third stage will provide the cornerstone of a new unified methodology meant to modify practise and outcomes of current experimental/imaging, analysis and modelling approaches. Our final stage will look at the changes brought to each of the specific research areas practises and how it impacts the understanding of soil structure and its functions.

It is expected that our proposal will foster bilateral collaborations within Europe and with our overseas partners through local and international funding, shared database and infrastructure management, and lead to the creation of a sustainable international network of researchers, infrastructure and institutes.";459000;175500;H2020-MSCA-RISE-2014;MSCA-RISE;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;FR;"AALBORG UNIVERSITET;AARHUS UNIVERSITET;NOVITOM SAS;UNIVERSITA DEGLI STUDI DI PADOVA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;UNIVERSITE GRENOBLE ALPES;UNIVERSITE DE LORRAINE";"DK;FR;IT"; 194440;646364;NANOFACTURING;SIGNED;H2020-EU.2.1.2.1.;NMP-08-2014;H2020;The Development of Medium- and Large-Scale Sustainable Manufacturing Process Platforms for Clinically Compliant Solid Core Nanopharmaceuticals;1/02/2015;31/01/2019;;"A number of nanomedicine formulations have enabled, or been shown to hold considerable potential for enabling more effective and less toxic therapeutic interventions. However, progress to date in translating these initiatives to commercial success has been limited. One of the main reasons for this bottleneck is due to the inability of researchers and stakeholders to manufacture batches of the nanomedicine product at the required scale and according to Good Manufacturing Practice (GMP) requirements. The NANOFACTURING project will focus on
- facilitating access to required infrastructures and expertise
- creating GMP pilot lines for up-scaling manufacturing
- addressing the current developmental and production gaps
- taking nanomaterials already successfully produced at proof-of-concept/milligram levels and facilitating their scale-up to sub-kilogram quantities
- providing large-scale and GMP production for clinical trials and nanomedicine translation.
The NANOFACTURING project, through a consortium of 9 partners, will develop the synthetic processes, process control methods, analytical assays for QA/QC, functional specifications, and best practices, interfacing existing R&D centres of excellence, transfer organisations and private GMP manufacturing facilities (including SMEs) to ensure efficient translation from discovery through to first in man, proof-of-concept studies and beyond to Phase III according to industrial and regulatory standards. Specifically, the NANOFACTURING project aims to create a platform process for early, mid- and large-scale manufacturing of glycan-coated gold nanoparticles (GNPs), a widely researched and developed class of self-forming nanoparticles. The ability to engineer new nanopharmaceuticals based on this patent protected platform technology, developed by Midatech Biogune S.L. (Project Coordinator), will have inherent advantages over existing treatments for multiple therapeutic areas.";8341906,75;7898781,5;H2020-NMP-PILOTS-2014;RIA;MIDATECH PHARMA ESPANA SL;ES;"Centre for Process Innovation Limited;INSTITUTO TUMORI GIOVANNI PAOLO II;MIDATECH LTD;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN;LGAI TECHNOLOGICAL CENTER SA;GALCHIMIA SA;PROCHIMIA SURFACES SP. Z O.O.;IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE";"UK;IT;CH;IE;ES;PL"; 194360;645686;HYMADE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes;1/02/2015;31/01/2019;;"HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. The capsules and particles have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis.
The project is based on the secondments of Early Stage Researchers and Experienced Researchers and networking and training activities between European and non European academic institutions.
HYMADE aims to profit from the combination of hybrid materials to fabricate advanced drug delivery systems with controlled release and targeting efficiency of biological entities. The project also aims to gain understanding of the self assembly process of hybrid materials and the transport properties of the drug delivery systems.The biological fate, drug release, degradation and therapeutical efficiency of the drug delivery systems will be studied in vitro and in vivo with state of the art imaging techniques. To achieve these goals we have gathered an international multidisciplinary team with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Biophysics and Imaging from Germany, Austria, France and Spain on the European side and from United States of America, Argentina and Armenia on the non European side.";1219500;1219500;H2020-MSCA-RISE-2014;MSCA-RISE;ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE;ES;"UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;Universitt Leipzig";"FR;AT;DE"; 194286;645127;ACINO;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;Application Centric IP/Optical Network Orchestration;1/02/2015;31/01/2018;;"The Internet has evolved into a three layer structure: at the top layer sit the applications generating traffic that is groomed at the IP and/or OTN layers and finally transported at the optical layer. Specific application needs, such as latency or protection requirements, are seldom guaranteed, because they are usually implicit and even when they are not, the need of the grooming layer to map large numbers of small flows into the small numbers of very large and static lightpaths is an obstacle to effective service fulfillment.

ACINO proposes a novel application-centric network concept, which differentiates the service offered to each application all the way down to the optical layer, thereby overcoming the disconnect that the grooming layer causes between service requirements and their fulfillment in the optical layer. This allows catering to the needs of emerging medium-large applications, such as database migration in data centers. To realize this vision, ACINO aims to develop an open source, vendor-agnostic modular orchestrator, which will expose to applications a set of high level primitives for specifying service requirements, and then perform multi-layer (IP and optical) planning and optimization processes to map these requirements into a set of lightpaths. The orchestrator will also be able to perform re-optimization, by means of a novel online in-operation planning module. The ACINO consortium has strong industrial foundations, and plans to demonstrate the advantages of its approach in a testbed with commercial equipment in a carrier environment.

ACINOs approach directly addresses the lack of dynamic control of optical networks, by automating planning and configuration tasks, and tackles the limitations in inter data center connectivity by allowing applications to request detailed and complex custom services to be provisioned in a timely manner. Overall, ACINOs open source and vendor-agnostic approach will foster the emergence of open industry standards.";2887055;2887055;H2020-ICT-2014-1;RIA;CREATE-NET (CENTER FOR RESEARCH AND TELECOMMUNICATION EXPERIMENTATION FOR NETWORKED COMMUNITIES);IT;"SEDONASYS SYSTEMS LTD;ADVA OPTICAL NETWORKING SE;TELEFONICA INVESTIGACION Y DESARROLLO SA;RESEARCH AND EDUCATION LABORATORY IN INFORMATION TECHNOLOGIES;RISE ACREO AB";"IL;DE;ES;EL;SE"; 194444;646469;P2P-SmarTest;SIGNED;"H2020-EU.3.;H2020-EU.3.3.;H2020-EU.3.3.4.";LCE-07-2014;H2020;Peer to Peer Smart Energy Distribution Networks (P2P-SmartTest);1/01/2015;31/12/2017;;P2P-SmartTest project investigates and demonstrates a smarter electricity distribution system integrated with advanced ICT, regional markets and innovative business models. It will employ Peer-to-Peer (P2P) approaches to ensure the integration of demand side flexibility and the optimum operation of DER and other resources within the network while maintaining second-to-second power balance and the quality and security of the supply. The proposed project will built upon extensive experience of the consortium on Information and Communications Technologies (ICT), especially ICT for the Energy Sector, Smart Grids including Distributed Energy Resources (DER) integration, MicroGrids, CELLs, Virtual Power Plants etc., power system economics, electricity markets and business models. The project comprises of 7 work packages (WP), of which 5 are technical WPs. Apart from project management (WP1) and dissemination and exploitation (WP7) the P2P-SmartTest project defines and demonstrates the suitable business models (WP2) for peer-to-peer based distributed smart energy grids, quantify the value from significantly increased system interaction and integration, and assess the required development in ICT and power networks in conjunction with commercial and regulatory frameworks to enable P2P trading realising its full potential. WP3 shall develop and demonstrate the distributed wireless ICT solutions capable of offloading the required traffic of different applications of energy trading, network optimization, AMR data and real-time network control to name a few. In WP4 the optimization mechanisms of energy flows in P2P context shall be defined, as well as market design solutions. To properly operate distributed network, WP5 shall integrate the necessary network operation functions for resilient distribution system operation. The results of WPs 2-5 will be integrated to demonstration and validation environment in WP 6 to provide real-life results of distributed energy system designs.;3866215;3496141,5;H2020-LCE-2014-3;IA;OULUN YLIOPISTO;FI;"REGENERA LEVANTE SL;FUNDACION CENER-CIEMAT;UNIVERSITY OF BATH;ENDESA SA;KATHOLIEKE UNIVERSITEIT LEUVEN;CARDIFF UNIVERSITY;INSTRUMENTACION Y COMPONENTES SA;CENTRE TECNOLOGIC DE TELECOMUNICACIONS DE CATALUNYA";"ES;UK;BE"; 194411;646080;ENF2015;SIGNED;"H2020-EU.2.1.3.;H2020-EU.2.1.5.;H2020-EU.2.1.2.";NMP-38-2014;H2020;EuroNanoForum 2015;1/07/2014;30/09/2015;;"This proposal is about organising the 2015 EuroNanoForum conference (ENF 2015) in Riga as part of the Latvian presidency of the European Union. The conference will focus in nano and materials technologies, strengthening European competitiveness and supporting the renewal and recovery from the economic crisis. The event will review the 2015 status of European nanotechnology, including the latest progress in nanoscience, innovations and business. The most relevant application fields and enabling technologies will be reviewed. In addition, the different aspects impacting European competitiveness will be covered, including smart specialisation, public-private partnerships, local support and Horizon 2020. In addition, the framework conditions like education, standardisation, regulations, IPR and safety issues, as well as issues related to entrepreneur- and industry-friendly decision making are included. The conference will also build on agendas of the previous conferences such as commercialisation and start-ups.
The conference will be organised on 10-12.6.2015. The conference will feature plenary sessions, presentations, workshops, poster sessions and a brokerage event. In addition, specific evening program for the speakers and delegates will be organised in order to give opportunities for networking during the conference days. The NanoTechEurope exhibition will complement the event as separate but parallel activity, showcasing various organisations and activities related to nanotechnology. The event will include also the best project, the best poster and the best exhibition stand competitions.
The European nanotechnology community, including the technology platforms and industrial associations, will be integrated in planning the content. A range of communications activities will assure extensive dissemination and wide participation in the event. The national outreach activities will activate the local nanotechnology community in Latvia and the Baltic States.";821675;599925;H2020-NMP-CSA-2014;CSA;LATVIJAS UNIVERSITATE;LV;SPINVERSE INNOVATION MANAGEMENT OY;FI; 194633;649905;LabelPack Aplus;SIGNED;H2020-EU.3.3.7.;EE-14-2014;H2020;Promotion and support to the implementation of the energy labelling for Space, Combi Heaters and Water Heaters with a focus on the Package label;1/03/2015;28/02/2018;;"The Label Pack A\ project aims at supporting the implementation of the energy labelling of heating appliances while boosting its impact, the focus being on the package label and its potential to push for the uptake or renewable technologies, in particular solar thermal, in combination with more efficient conventional technologies.

The project will address one of the main challenges related to this particular energy labelling process in relation to other Energy-related Products : the issuing of the package label by installers. This challenge involves the preparation of the industry, retailers and installers to this process, including the communication to the final consumer.

Therefore, the main objectives of the project are to:
- Provide guidelines, as well as standardized answers to clarify the responsibility of each actor in the supply chain. These activities will, in particular, focus on installers and SMEs, who might be facing specific implementation challenges;
-> Facilitate the exchange of product fiches and product related information on the format of equipments databases, available to all the actors in the energy labelling process;
-> Apply the energy labelling calculation methodology and make it available to all the actors in the supply chain in the form of a user-friendly online calculation tool;
-> Develop and provide industry specific training material, especially focusing on the responsibilities and roles of installers in the energy labelling process;
-> Provide tailor-made information for end consumers, which will either be directly accessible by them, or used by dealers to explain the significance and added value of the package label;
-> Provide consolidated expertise on the energy labelling process to the Commission and national authorities, based on the experiences gathered on the pilot implementation in the participating countries.";1385797,5;1385797,5;H2020-EE-2014-3-MarketUptake;CSA;European Solar Thermal Industry Federation;BE;"LEGAMBIENTE ASSOCIAZIONE ONLUS;ECLAREON GMBH;ENERPLAN;ASSOCIACAO PORTUGUESA DA INDUSTRIA SOLAR;SOLAR TRADE ASSOCIATION LIMITED;ASSOLTERM;ADENE-AGENCIA PARA A ENERGIA;BSW - BUNDESVERBAND SOLARWIRTSCHAFT E.V.;DECO -ASSOCIACAO PORTUGUESA PARA ADEFESA DO CONSUMIDOR;AUSTRIA SOLAR";"IT;DE;FR;PT;UK;AT"; 194688;650908;EUROCATED;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.4.";IT-1-2014-1;H2020;Innovative services and platform for sustainable transport based on ecodriving techniques;1/10/2014;31/01/2015;;"Eurocated project main objective consists of taking advantage of the opportunity presented in the market by the necessity of saving costs and reduce emissions in terms of fuel combustion in the operation of all kind of road transport professional fleets.
Based on the principle of efficient driving, the solutions, products and services, proposed by this project, will fit a market all around Europe of more than 200 million per year. Only Spanish market is ranged over 10 million per year. Thousands of vehicles from public and private fleets will save billions and tones of emissions, and fleet operators interest is growing as they become aware of the benefits of efficient driving technology supported systems over traditional training courses. Only a medium size city urban bus operator could save 375 thousand per year and reduce emissions in 750 Tn per year.
ADN Mobile Solutions distinguishes by its excellence in R&D activities that have permitted the firm to currently count with the most specialized, competitive and market oriented tech-powered efficient driving solution. After 4 years of developments, and with the support of public and private investors, the product has already achieved a TRL of 7, with operation on course of real trials and pilots in a number of early-adopters of the product: It is worth mentioning bus urban fleets operating in Valencia (Spain) and Oslo (Norway) cities as well as the already shown interest of Istanbul (Turkey) city .
The feasibility study aims to prepare completed full operation plan that will fill the gap between the current product and the version to be widely disseminated and introduced at European level. ADN expectations consist of reaching an annual turnover of 10 million by the end of 2019 with a phase II funding requirement estimated 1 million .";71429;50000;H2020-SMEINST-1-2014;SME-1;ADN CONTEXT - AWARE MOBILE SOLUTIONS SL;ES;;; 194537;648505;CSF;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;From Cloud to Star Formation;1/09/2015;31/08/2020;;"Star Formation is a hierarchical process from the build-up of large clouds to the assembly of stars. This ERC project aims at studying the multi-scale processes of this conversion from diffuse gas to stars. The fundamental data are provided by two PI-led large observing programs at two of the most advanced radio and mm interferometers, the Very Large Array (VLA) and the Plateau de Bure Interferometer (PdBI). This combined approach is designed to address outstanding key questions in the field of cloud and star formation.
The 225 hours THOR program at the VLA investigates the cloud formation and conversion of atomic to molecular gas, as well as feedback processes back to the interstellar medium (ISM). To reach these goals, THOR observes the Milky Way in atomic HI, molecular OH, and cm continuum and radio recombination lines tracing the ionized components of the ISM.
At smaller spatial scales, the 300 hours PdBI project CORE will study the fragmentation of the gas clumps to form clusters, the formation of accretion disks and outflows, and the gas infall rates as proxy for the accretion rates. Therefore, assisted by Atacama Large Millimeter Array (ALMA) observations, we will investigate a sample of high-mass star-forming regions at the highest spatial resolution of 0.2' to dissect the physical processes during the assembly of the highest mass stars.
The core aim of this ERC project is to study all spatial scales from molecular clouds to individual massive cores. This will be a decisive step in the understanding of the conversion of gas and dust into stars. Through his decade-long expertise and leadership in star/cloud formation, the PI is uniquely positioned to advance the field significantly. The surveys at the heart of the program are extremely computing and work intensive accumulating data in the 100 TByte regime. This proposals asks for a strong core group of three postdocs and one PhD student to conduct the project and fully exploit the scientific results.";1616050;1616050;ERC-2014-CoG;ERC-COG;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;DE;;; 194580;649436;Re.Cri.Re.;SIGNED;H2020-EU.3.6.;EURO-3-2014;H2020;Between the representation of the crisis and the crisis of representation. How crisis changed the symbolic background of European societies and identities. Implication for policies and policy making;1/05/2015;30/04/2018;;"This project aims to understand what kind of social identity change is going on within European societies. For policy-making, the analysis of social identity is highly valuable because the social identity moderates the impact of policies. And this is particularly true in times of crisis. In particular, the project aims: A) to verify whether the symbolic universes grounding the social identity has undergone a major change within European societies, as a consequence of the socio-economic crisis; B) to draw strategic and methodological implications for policy-making from point A. This project includes 4 core scientific work packages: a) Multilevel Analysis of the Symbolic Universes, aimed at mapping structurally and developmentally the systems of meaning (i.e. the symbolic universes) grounding the social identity; b) Case Studies for policies, aimed at see how different policies have been organized and how their impact might or might not have been moderated by the symbolic dynamics at stake; c) the results of this analysis will be transformed into abstract criteria, contextualised in 5 different European macro-Regions, discussed with stakeholders, opinions leaders, policy-makers and finally stored within the guidelines; d) finally, the guidelines will be validated in terms of pertinence, effectiveness and the feasibility criteria, through seminars with the policy makers, opinion leaders and stakeholders, belonging to national, European, international Agencies involved in the construction and implementation of policies. Also, focus groups will be organized in each cultural context in order to study the impact of context-specific criteria.";2719238,33;2719238,33;H2020-EURO-SOCIETY-2014;RIA;ASSOCIATION DES AGENCES DE LA DEMOCRATIE LOCALE;FR;"UNIVERSITA DEGLI STUDI ROMA TRE;UNIVERSITA DEL SALENTO;NEW BULGARIAN UNIVERSITY;AALBORG UNIVERSITET;UNIVERSITA TA MALTA;ARISTOTELIO PANEPISTIMIO THESSALONIKIS;PANEPISTIMIO KRITIS;TALLINN UNIVERSITY;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;ISTITUTO SCIENTIFICO BIOMEDICO EUROMEDITERRANEO SCPA;UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA;UNIVERSITE D'AIX MARSEILLE;University of Leicester;UNIVERSITY OF CYPRUS;UNIVERSITEIT VAN AMSTERDAM";"IT;BG;DK;MT;EL;EE;DE;ES;FR;UK;CY;NL"; 194365;645699;UNICAT;TERMINATED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Unique Biomaterial-Drug Solution for Multifunctional Central Venous Catheters;1/01/2015;31/12/2017;;"Central venous catheters (CVCs) play a critical role in healthcare and few medical devices are more important and widespread in modern medicine. Catheter-related bloodstream infection (CRBSI) is the most common life-threatening complication of CVCs. Reducing the risk of CRBSI among patients would save costs, reduce length of stay and improve mortality and morbidity.
The major challenge of UNICAT is thus to develop a new CVC solution to prevent infection and thrombosis. The project partners will introduce a whole new way of thinking by introducing a disruptive approach which is more than just a coating of devices. A new material will, for the first time, combine ultra-biocompatibility with chemical resistance and desired mechanical properties, to effectively prevent adverse host response, inflammation and infection. A major problem in biomaterials science is that bioresistant materials are inevitably also chemically inert and hence highly difficult to manipulate by traditional wet chemistry. If manipulation (e.g. coating) is achieved, the solution is often unstable and fragile. UNICAT will address this problem by combining two materials using a novel method based on super critical CO2-chemistry. It will result in a hybrid material which is stably formed and combines the best properties of two or more materials.
The success criterion is to exceed performance of coatings by producing the first fully biocompatible material to be used as sole robust bulk material of vascular access lines.
UNICAT is an international and inter-sector collaborative project comprising R&D activities and secondments between the SME BioModics (BM), the University of Minho (UMinho), the Bar-Ilan University (BIU) and the Simula Research Laboratory (Simula). The consortium has identified the RISE programme as a suitable vehicle for overcoming the identified major challenges and for bridging the knowledge gap, while helping to overcome the financial, technological and intersectoral barriers.";207000;207000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSIDADE DO MINHO;PT;"BIOMODICS APS;SIMULA RESEARCH LABORATORY AS;BAR ILAN UNIVERSITY";"DK;NO;IL"; 194522;647939;CosmicDust;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Lighting up the dark - the evolution of dust throughout cosmic time;1/09/2015;31/08/2020;;"After more than two decades of infrared astronomy, we still know very little about the origin and evolution of cosmic dust in galaxies, responsible for obscuring half of all starlight since the Big Bang. This obscured starlight is re-radiated in a region of the electromagnetic spectrum that is still relatively unexplored. Herschel provides a unique opportunity to resolve this by revealing the 90% of dust too cold to be detected before, yet only a tiny fraction of the largest survey of the sky carried out with Herschel has been exploited.

This project aims to unravel the dust and gas content of galaxies in the local universe and over cosmic time. I will produce the first statistical census of dust in galaxies, pushing out to earlier cosmic epochs than previously possible. This also provides us with an opportunity to detect unusual objects not seen in other surveys, including a population of extremely dusty galaxies found in Herschel with blue optical colours and very different properties to more evolved spirals typical of the Milky Way. I will use our multi-wavelength data to investigate the emissivity, gas and star formation conditions on resolved spatial scales. Our Herschel data will also expose the role of environment in the interstellar content of early-type and spiral galaxies.

I propose a novel approach to resolve the controversy of whether dust forms in exploding stars using polarized light. This could have implications for the detection of polarized signals in the relic radiation from the Big Bang, currently attributed to primordial gravitational waves. Our polarized dust maps of nearby supernova will reveal whether this could be a major contaminant to cosmological signals.

This project is timely due to the availability of final Herschel data products and new facilities in 2015-16 in combination with tools and techniques that we have tried and tested. This ERC award will provide me with the resources to continue to lead this emerging field.";1789713,75;1789713,75;ERC-2014-CoG;ERC-COG;CARDIFF UNIVERSITY;UK;;; 194329;645497;WeHubs;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;The European network of Women web Entrepreneurs Hubs;1/01/2015;31/12/2016;;"It is generally acknowledged that the web entrepreneurship sector can contribute significantly to the competiveness and economic growth of countries and regions. However, Europe is clearly lagging behind given that even though there are lots of European web start-ups, most of them rarely grow up to become global leaders. In this context, the position of women seems particularly weak given that only a very small percentage of them are web entrepreneurs.
Taking into account the limited development of web entrepreneurship in Europe as well as the limited participation of women in the web economy the WeHubs project seeks to create a favourable environment for women web entrepreneurs, by linking together local fragmented ecosystems nodes, and foster networking and exploitation of synergies, into the first European Network for Women Web Entrepreneurs Hubs. In this respect the project is aimed at providing a strong support to women web entrepreneurs and existing web entrepreneurs ecosystems enabling the latter to provide dedicated services to women.
As a result the project will foster the creation and scaling of web start-ups created by women (impact on women), strengthen the existing web entrepreneurs ecosystems through networking and complementary services (impact on ecosystems) and support the emergence of a dynamic European ecosystem for women web entrepreneurs contributing to the formulation of relevant policies, support the implementation of start-up Europe initiative and the wider enforcement of the European digital sector (policy impact).";756721,25;756721;H2020-ICT-2014-1;CSA;EUROPEAN BUSINESS AND INNOVATION CENTRE NETWORK AISBL;BE;"INTERINNOV SAS;MEDIA DEALS UG (HAFTUNGSBESCHRNKT);ENTERPRISING WOMEN LIMITED LBG;VILABS OE;EUROPEAN CENTRE FOR WOMEN AND TECHNOLOGY (ECWT) FORENING;BERYTECH FOUNDATION;Media deals;Founder Institute Europe";"FR;DE;UK;EL;NO;LB"; 194413;646113;ENATRANS;SIGNED;"H2020-EU.2.3.2.2.;H2020-EU.2.1.2.;H2020-EU.2.3.2.1.";NMP-09-2014;H2020;Enabling NAnomedicine TRANSlation;1/01/2015;31/12/2017;;"ENATRANS main objective is to network and support SMEs in translation of nanomedicine in Europe by providing a one-stop-shop service to interact and share information, experience and advice with up-to-date information and interactive tools, but also enabling personal contacts.
To be successful SMEs need to understand the requirements of the complex ecosystem made up of regulatory and reimbursement agencies, as well as the requirements of large industrial companies and clinical needs. ENATRANS will gather and provide information about approval processes, regulatory authorities and agencies, clinical and market data, and specific nanomedicine value chain analysis, relevant SME support projects and organisations. ENATRANS will convert this critical information in dedicated learning programs and tools dedicated to translation of nanomedicine.
ENATRANS aims at implementing the concept of a Translation Advisory Board (TAB) as central element of the ETPN White Paper. A TAB will be set-up with senior experienced translation experts to guide R&D teams (in SMEs and research institutes) along the translation process to successfully make it to clinical trials and later to the market.
Promising projects identified and supported by the TAB need access to clinical centers for first studies in patients, which are able to handle the specificity of new nanotechnology based therapeutics. In addition, financial resources are needed to go pass the regulatory and scale-up processes, which often require funding from investors and/or large companies. ENATRANS will build bridges to clinical trial centers, investors and large companies.
Promising projects need guidance to successfully master privileged contacts with the medical, the business or the investment community. ENATRANS will deliver special coaching sessions prior to showcasing of promising projects.
Partners in ENATRANS are VDI/VDE-IT, Nanobiotix, CEA, bioanalytik-muenster, Tel Aviv University, Fondazione Don Gnocchi, TecMinho.";1999406,25;1999406;H2020-NMP-CSA-2014;CSA;VDI/VDE INNOVATION + TECHNIK GMBH;DE;"GESELLSCHAFT FUR BIOANALYTIK MUNSTER EV;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;NANOBIOTIX SA;TEL AVIV UNIVERSITY;ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO;FONDAZIONE DON CARLO GNOCCHI ONLUS";"DE;FR;IL;PT;IT"; 194565;649255;GEMM;SIGNED;H2020-EU.3.6.;EURO-2-2014;H2020;Growth, Equal Opportunities, Migration and Markets;1/09/2015;31/08/2018;;"The Horizon 2020 programme of the European Commission provides an important opportunity for advancement of our knowledge of growth and innovation in the European Union labour markets as well as the dynamism that creates inclusive but competitive social environments. The GEMM project relates in particular to the Migration, Prosperity and Growth Dimension of the Call on the European Growth Agenda. With over 30 researchers located in several EU member states and Norway, our consortium will approach the topic and deliver:
- An analysis of the obstacles to the successful incorporation of migrants and in particular to the attraction and retention of highly-skilled migrants;
- A thorough assessment of the migration-related drivers of growth and the optimal functioning of markets;
- An assessment of ethnic inequality in the labour market as a barrier to competitiveness and innovation in EU member states.
- A set of policy recommendations that contain concrete guidelines as to how migrants can contribute to the EU economy and society

These deliverables are realised by putting forward a scientifically innovative research agenda that combines a variety of methods and crosscutting expertise. Our consortium contains economists, sociologists, political scientists, and anthropologists who have made outstanding contributions to the field of migration and inequality research. Furthermore, our empirical approach is multi-method; we make use of survey, experimental and qualitative research methods to advance knowledge.";2498510;2498510;H2020-EURO-SOCIETY-2014;RIA;UNIVERSITY OF ESSEX;UK;"UNIVERSITETET I OSLO;NEW EUROPE CENTER FOR REGIONAL STUDIES SDRUZHENIE;UNIVERSITEIT UTRECHT;CENTRUL DE SOCIOLOGIE URBANA SI REGIONALA - CURS SRL;THE WARDEN AND FELLOWS OF NUFFIELD COLLEGE IN THE UNIVERSITY OF OXFORD;WISSENSCHAFTSZENTRUM BERLIN FUR SOZIALFORSCHUNG GGMBH;UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA;UNIVERSIDAD CARLOS III DE MADRID;UNIVERSITEIT VAN AMSTERDAM";"NO;BG;NL;RO;UK;DE;IT;ES"; 194350;645660;TUMOCS;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;TUneable Multiferroics based on oxygen OCtahedral Structures;1/01/2015;31/12/2018;;The main objective of the project is development of new lead-free multiferroic materialshe for prospective application in forms of films and/or arranged layers in which the cross-coupling (magnetic-dipolar-elastic) can be tuned by both internal and external factors. This objective is to be achieved through preparation, investigation, and optimization of two kinds of Bi-containing oxygen-octahedral (BCOO) systems with paramagnetic ions involved: metastable perovskites and layered double hydroxides (LDHs). The characteristic feature of such materials is a possibility of supplementary control parameters in addition to temperature and external electric/magnetic field. Polarization in such metastable perovskites is easily switched by application of external pressure (or stress in the case of films). Electric and magnetic characteristics of BCOO LDHs are tuned through appropriate anion exchanges. It makes these characteristics dependent on environment conditions: humidity, pH, and presence of specific anion species. The BCOO materials of both mentioned groups are of interest as new and unusual multiferroics. No LDH materials have been considered as potential multiferroics so far, while the metastable BCOO materials proposed in this project have not been obtained before. Besides, a tuneability and high sensibility of their properties to external impacts make them promising for applications in sensors. Exploration and development of such materials require consolidation of specialists of complementary expertise in Physics, Chemistry, and Materials Science, with access to and skills in using specific and unique equipment and facilities. Therefore, formation of an interdisciplinary network of teams with different scientific culture and ensuring the effective knowledge & expertise transfer is important objective of the project. Advance in development of the BCOO multiferroics has potential market opportunities for R&D SME involved in this project.;814500;814500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSIDADE DE AVEIRO;PT;"VILNIAUS UNIVERSITETAS;SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;UNIVERSITAET DUISBURG-ESSEN;HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH;SMALLMATEK - SMALL MATERIALS AND TECHNOLOGIES LDA";"LT;UK;DE;PT"; 194396;645845;WeLive;SIGNED;H2020-EU.3.6.;INSO-1-2014;H2020;A neW concept of pubLic administration based on citizen co-created mobile urban services;1/02/2015;31/01/2018;http://www.welive.eu/;The WeLive project is devised to transform the current e-government approach by facilitating a more open model of design, production and delivery of public services leveraging on the collaboration between public administrations (PAs), citizens and entrepreneurs. WeLive applies the quadruple-helix approach based on the joint collaboration of 3 PAs, 4 research agents and 5 companies, constituing the consortium, plus citizens to deliver next generation personalised user-centric public services. WeLive aims to bridge the gap between innovation and adoption (i.e. take-up) of open government services. For that, it contributes with the WeLive Framework, an ICT infrastructure which adapts, enhances, extends and integrates Open Innovation, Open Data and Open Services components selected from consortium partners previous projects. An Open Innovation Area is proposed where stakeholders collaborate in the ideation, creation, funding and deployment of new services. A Visual Composer will enable non-ICT users to assemble public service apps from existing blocks. Stakeholders will upload/sell and download/purchase the generated apps to/from the WeLive Marketplace, thus impulsing economic activity around public services. Personalization and analytics of public services will be done through collaboration of the Citizen Data Vault, which manages personal information, with the Decision Engine, which matchmakes user preferences, profile and context against available public services. Two-phase pilots will be conducted in 3 cities (Bilbao, Novi Sad and Trento) and 1 region (Helsinki- Uusimaa) across Europe. Further, the business feasibility and commercial potential of the WeLive Framework, including its individual assets, will be validated by developing and deploying sustainable business models.;3367581,25;2973580;H2020-INSO-2014;IA;FUNDACION TECNALIA RESEARCH & INNOVATION;ES;"DRUSTVO ZA KONSALTING, RAZVOJ I IMPLEMENTACIJU INFORMACIONIH I KOMUNIKACIONIH TEHNOLOGIJA DUNAVNET DOO;ENGINEERING - INGEGNERIA INFORMATICA SPA;COMUNE DI TRENTO;CLOUD'N'SCI OY;CITY OF NOVI SAD;AYUNTAMIENTO DE BILBAO;JAVNO KOMUNALNO PREDUZECE INFORMATIKA NOVI SAD;EUROHELP CONSULTING SL;LAUREA-AMMATTIKORKEAKOULU OY;FONDAZIONE BRUNO KESSLER;UNIVERSIDAD DE LA IGLESIA DE DEUSTO";"RS;IT;FI;ES"; 194673;650594;NiGlucoMon;SIGNED;"H2020-EU.2.3.1.;H2020-EU.3.1.";PHC-12-2014-1;H2020;A Non-Invasive GLUCOse MONitoring device for diabetics based on Stimulated Raman Spectroscopy in a quick, cheap and painless method.;1/10/2014;31/03/2015;;"Today, diabetics must carry out a finger prick test as part of their blood glucose level management. It is recommended to do this test at least 4 times a day. Many diabetics fail to do so even once for a number of reasons: pain avoidance, disliking the sight of blood, cost of the test strips, the test protocol and the risk of infection. This failure to manage blood glucose levels has serious long term implications. Heart disease and blood vessel disease are the biggest complications that people with uncontrolled diabetes face. Blood vessel damage or nerve damage also lead to chronic foot and leg ulcers called diabetic foot that can result in amputations. More than 60% of leg and foot amputations not related to an injury are due to diabetes which is also the cause of new blindness and kidney disease. Our solution is a non-invasive glucose monitor that will allow people with diabetes to monitor their blood glucose levels in a quick and painless manner, for a low price.
When using normal Raman Spectroscopy very little light undergoes Raman scattering, therefore high integration times are required to achieve a usable signal-to-noise ratio. Expensive optics are necessary for collecting, isolating and dispersing the light. Our technique and system packaging promises to overcome all of these obstacles.
We use Stimulated Raman Spectroscopy, created when two light beams interact with each other in the presence of glucose. The energy is transferred from one beam of light to the other, and this transfer is proportional to the number of glucose molecules present. By measuring this energy transfer using a simple and inexpensive power meter, the glucose concentration is measured without the need for dispersing the light and analyzing the Raman Spectrum. A patent has been applied for.
We have completed the Technology Readiness Level 2 (technology concept formulated) and plan to complete Technology Readiness Level 3 (Experimental Proof of concept) in this project.";71429;50000;H2020-SMEINST-1-2014;SME-1;2M ENGINEERING LIMITED;UK;;; 194506;647544;PAW;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Automated Program Analysis for Advanced Web Applications;1/08/2015;31/07/2020;;"Web applications that execute in the user's web browser constitute a substantial part of modern software. JavaScript is the main programming language of the web, although alternatives are emerging, in particular, TypeScript and Dart. Despite the advances in design of languages and libraries, it is difficult to prevent errors when programming such web applications. Although the basic principles of software verification have been known for decades and researchers have developed an abundance of techniques for formal reasoning about programs, modern software has lots of errors, as everyday users can testify.

The PAW project will create novel automated program analysis algorithms for preventing errors and improving performance of advanced web applications. The project hypothesis is that a scientific breakthrough is within reach, due to recent results in static and dynamic program analysis for JavaScript. The central idea is to combine static and dynamic analysis in new ways. In addition, the project will make program analysis algorithms and infrastructure available in a form that embraces reusability.";1977382;1977382;ERC-2014-CoG;ERC-COG;AARHUS UNIVERSITET;DK;;; 194397;645846;MERID;SIGNED;H2020-EU.3.6.;INT-02-2014;H2020;Middle East Research and Innovation Dialogue;1/01/2015;31/12/2017;;"The MERID project (Middle East Research and Innovation Dialogue) proposes a comprehensive action to intensify and encourage research and innovation cooperation between the EU and the Middle East region, directly involving partners from Egypt, Iran, Iraq, Jordan, Lebanon and Palestine, directly involving partners from Egypt, Iran, Iraq, Jordan, Lebanon and Palestine. The project intends to build upon the experience carried out in countries of the region that have already participated in the previous framework programmes, and therefore are at a relatively advanced stage of research cooperation with Europe, like Egypt and Jordan. Attention is paid to calibrating in the most appropriate way the intervention logic of the project, adapting actions to the specific needs of the target countries and their research constituencies. The needs of Iran and Iraq will for sure prove different from those of countries where cooperation with the EU has a proven track record behind.

The project is the first attempt to systematise support to the policy dialogue and involvement of research communities of Iran and Iraq in the H2020 programme, as well as an initiative that seeks to give continuity to collaboration frameworks already established between the EU and Middle East countries. The project has high potential to deliver long-lasting impact and structuring effects on cooperation between the EU and the Middle East region. It focuses on enhancing direct cooperation among researchers and on laying or consolidating preconditions, in the region, fostering joint research projects and initiatives with the EU, establishing optimal framework conditions for international cooperation and increasing coordination between policies and programmes. These objectives will be achieved through series of different on-line and in-person activities, among which are meetings of researchers, brokerage events, info-days, training and coaching, webinars and other tools, relevant for this project proposals.";999750;999750;H2020-INT-INCO-2014;CSA;EVRO-SREDOZEMSKA UNIVERZA;SI;"UNIVERSITY OF JORDAN;Islamic University of Gaza;CERISS - KENTRO PERIFEREIAKON KAI DIETHNON MELETON KAI YPOSTIRIXIS MONOPROSOPI IKE;FUNDACION ESADE;CENTRO INTERNAZIONALE DI ALTISTUDI AGRONOMICI MEDITERRANEI;CONSEIL NATIONAL DE LA RECHERCHE SCIENTIFIQUE;EUROPE FOR BUSINESS LTD;SUSTAINABLE COMMUNICATION AISBL;IRANIAN ASSOCIATION FOR MANAGEMENT OF TECHNOLOGY;MINISTRY OF HIGHER EDUCATION AND SCIENTIFIC RESEARCH;FREIE UNIVERSITAET BERLIN;MINISTRY OF SCIENCE AND TECHNOLOGY";"JO;PS;EL;ES;IT;LB;UK;BE;IR;EG;DE;IQ"; 194424;646374;M-Future2015;SIGNED;"H2020-EU.2.1.3.;H2020-EU.2.1.5.;H2020-EU.2.1.2.";NMP-38-2014;H2020;Strategic investments in European manufacturing to win global challenges;1/12/2014;31/03/2016;;"As a coordination and support measure this project is aimed to increase the efforts of the EC and the Member States in pursuing the strategic objective of Europes reindustrialization and growth during Luxembourgs Presidency of the Council of the EU (June-December 2015) through the organization of the MANUFUTURE 2015 conference focused on options for strategic investments in European manufacturing.
The main objective of the conference is to identify and endorse new policy instruments, business models, support mechanisms and technologies that could help to strengthen and improve the manufacturing base in Europe given the existing regulatory framework and the constrains that EU manufacturers face on the global markets at this critical time.
More specifically, the conference aims to involve in the consultation process over 750 stakeholders (policy makers, business leaders, innovators and academics) representing all manufacturing sectors in the EU27.
The conference is structured along three major themes, including the issues related to widening access to finance for reindustrialisation and growth, moving European industry to the higher end of value chains, and creating synergy of support initiatives at EU level and in Member States with increased participation of financial markets. For each theme a list of sub-issues to be addressed by speakers have been identified through a consultation process with the High Level Group of Manufuture and the Ministries of Economy and Higher Education and Research which have endorsed the initiative of LXI to host this event.
The proposal addresses the work programme topic NMP-38-2014 which calls for organising an event of a major strategic nature during the EU presidency of Luxembourg that could contribute towards creating better synergies between public and private initiatives to the benefit of the coherence of the overall actions within the field of research and innovation for the manufacturing sector.";867203,75;600000;H2020-NMP-CSA-2014;CSA;LUXINNOVATION GIE;LU;"FEDIL BUSINESS FEDERATION LUXEMBOURG;FONDS NATIONAL DE LA RECHERCHE;UAB EUROPARAMA;FARVEST SARL";"LU;LT"; 194618;649772;TRUST-EPC-SOUTH;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Building TRUST in Energy Performance Contracting for tertiary sector energy efficiency and sustainable energy projects in Southern European Countries;1/03/2015;28/02/2018;;"The overall objective of TRUST-EPC-SOUTH is to scale up investments on Energy Efficiency (EE) and other Sustainable Energy (SE) in the tertiary sector of southern European countries, with particular focus on Energy Performance Contracts (EPC) projects. This objective will be achieved through the development of an ad hoc investment standardization and benchmarking framework and supported with the organisation of tailored capacity building activities that will allow project developers (including ESCOs , ESPCs and other EPC providers), project sponsors and tertiary sector actors to more easily access third party financing, thus unlocking the large tertiary sector EE/SE market potential.

Geographically, the project will be carried out in the following 6 countries: Portugal, Spain, France, Italy, Croatia and Greece, in which we both see a need to improve the situation and a large untapped market potential in the tertiary sector.";1936975;1936975;H2020-EE-2014-3-MarketUptake;CSA;CREARA CONSULTORES SL;ES;"Ambiente Italia s.r.l.;ENERGIA PROPRIA SA;SELF ENERGY ENGINEERING & INNOVATION, SA;ENERGIES 2050;LIFEGATE SPA;BUREAU VERITAS IBERIA SL;OFFICINAE VERDI SPA;ASSOCIATION GREEN RATING ALLIANCE;ENERGETSKI INSTITUT HRVOJE POZAR;THE RESEARCH COMMITTEE OF THE TECHNICAL UNIVERSITY OF CRETE";"IT;PT;FR;ES;HR;EL"; 194356;645672;AMMODIT;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Approximation Methods for Molecular Modelling and Diagnosis Tools;1/08/2015;31/07/2019;;"This proposal brings together research teams from the EU (Germany, Italy, and Austria) and the Ukraine (Kyiv, Donezk) in the area of applied mathematics with emphasis on medical and life science applications.

The goal is joint research in six research tasks concerning the study of mathematical methods for Magnetic Particle Imaging; entropy-like measures and quantification of system complexity; coarse-grain modelling for (bio)polymers; diagnostic tools for cardiac surgery; regularization methods for causality detection; meta-learning approach to Nocturnal Hypoglycemia prediction. Each such task will incorporate 24 months of research secondments (18 to the EU, 6 to UA).

Four project events (one per year), each including a scientific workshop, a training school and public outreach activities, are planned to be held in the Ukraine involving a total of 27 secondment months.

Senior scientists from Ukraine will have 15 secondment months targeted apart from scientific and management work - at discussing issues how their institutions should develop in a restructuring of the Ukrainian research landscape.";823500;823500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITAET ZU LUEBECK;DE;"POLITECNICO DI MILANO;OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN";"IT;AT"; 194271;645011;SERECA;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Secure Enclaves for REactive Cloud Applications;1/03/2015;28/02/2018;;"Cloud security is of immediate concern to organisations that must comply with strict confidentiality and integrity policies. More broadly, security has emerged as a commercial imperative for cloud computing across a wide range of markets. The lack of adequate security guarantees is becoming the primary barrier to the broad adoption of cloud computing.
The Secure Enclaves for REactive Cloud Applications (SERECA) project aims to remove technical impediments to secure cloud computing, and thereby encourage greater uptake of cost-effective and innovative cloud solutions in Europe. It proposes to develop secure enclaves, a new technique that exploits secure commodity CPU hardware for cloud deployments, empowering applications to ensure their own security without relying on public cloud operators. Secure enclaves additionally support regulatory-compliant data localisation by allowing applications to securely span multiple cloud data centres.
Although secure enclaves are a general mechanism, SERECA focuses on a particularly important and rapidly growing class of applications: reactive applications for the Internet of Things (IoT), Cyber-Physical Systems (CPS), augmented reality, gaming, computer-mediated social interaction, and the like. These applications are highly interactive, data intensive, and distributed, often involving extremely sensitive societal and personal information.
SERECA is validating its results through the development of two innovative and challenging industry-led use cases. One concerns the monitoring of a civil water supply network, a critical infrastructure targeted by malicious attacks. The other concerns a commercial software-as-a-service (SaaS) application for analysing the performance of cloud-deployed applications. Such a service collects sensitive performance metrics about live usage, assets that must be protected from industrial espionage and other criminal activities.";3834340;3834340;H2020-ICT-2014-1;RIA;TECHNISCHE UNIVERSITAET DRESDEN;DE;"ENTE PER LO SVILUPPO DELL'IRRIGAZIONE NELLA PUGLIA BASILICATA IRPINA;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;RED HAT LIMITED;JCLARITY LIMITED;CLOUD&HEAT TECHNOLOGIES GMBH;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;EPSILON S.R.L.";"IT;UK;IE;DE"; 194398;645852;DIGIWHIST;SIGNED;H2020-EU.3.6.;INSO-1-2014;H2020;The Digital Whistleblower. Fiscal Transparency, Risk Assessment and Impact of Good Governance Policies Assessed;1/03/2015;28/02/2018;http://digiwhist.eu/;"Increasing both transparency and efficiency of public spending in the age of austerity presents formidable challenges for European societies. Innovative, open data tools hold the key to simultaneously meet both. The key objective of the proposed project is to combine the provision of data on public spending in the area of public procurement with actionable governance indicators and a monitoring procedure facilitating whistleblowing and thus strengthening accountability and transparency of public administrations.
Since public procurement is prone to corruption and budget deficit risks, high quality open data and innovative assessment tools in this area are especially relevant for the efficient and transparent use of public resources. The project, in particular, aims to systematically collect, analyse, and broadly disseminate tender-level information on public procurement in 35 jurisdictions across Europe. This data will be linked to company and public organisation information on finances and ownership and to information on mechanisms that increase accountability of public officials in order to systematically investigate the patterns and mechanisms of allocation of public resources in Europe. The proposed project addresses directly the objectives of the call by using innovative ICT-based measures and services which will provide wide access to information about governments spending and additionally involve private and public agents to actively collaborate in improving the quality and volume of the relevant data.
Partners represent an effective combination of large, well-renowned institutions and small and highly-innovative ones, including scientists and researchers from computer and political sciences, sociology, criminology, and economics at 6 institutions from 4 European countries, both old and new members states. The project builds extensively on the partners prior innovative work in this area as well as their rich experience with EU funded projects.";3026360;2980880;H2020-INSO-2014;IA;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;"DATLAB SRO;AKKI ATLATHATO KORMANYZAS KUTATOINTEZET KFT;OPEN KNOWLEDGE FOUNDATION DEUTSCHLAND;Universit Cattolica del Sacro Cuore;HERTIE SCHOOL OF GOVERNANCE GGMBH";"CZ;HU;DE;IT"; 194314;645369;iBROW;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;Innovative ultra-BROadband ubiquitous Wireless communications through terahertz transceivers;1/01/2015;31/12/2017;;The demand for broadband content and services has been growing at tremendous rates, and predictions indicate that wireless data-rates of multiple tens of Gbps will be required by the year 2020, essentially for short-range connectivity. Currently available wireless technology cannot support these future demands, and so there is an urgent need to develop new technology platforms that are cost and energy efficient to enable ubiquitous ultra-broadband wireless communications seamlessly integrated with high-speed fibre-optic networks, paving the way for 100 Gbps datarates in the long term. The frequency spectrum currently in use is not expected to be suitable to accommodate the predicted future data-rate requirements, and therefore there is a need to embrace higher frequency bands, above 60 GHz and up to 1 THz. iBROW aims at developing a novel, low cost, energy-efficient and compact ultra-broadband short-range wireless communication transceiver technology, capable of addressing predicted future network usage requirements. This will be pursued through the exploitation of Resonant Tunnelling Diode (RTD) devices which represent the fastest pure solid-state electronic devices operating at room temperature with reported working frequencies exceeding 1 THz. Through the development of a unified technology that can be integrated into both ends of the wireless link, namely consumer portable devices and fibre-optic supported base-stations, the project aims at increasing the RTD output power, optical detection efficiency and energy efficiency at target frequencies, developing a methodology for low cost RTD manufacturing on a silicon platform, photonic integration and packaging, as well as identifying appropriate communication methods and architectures to enable its deployment in 10 Gbps short-range wireless communication devices in short term and paving the way for 100 Gbps in long term for both the mm-wave and THz frequency bands, seamlessly integrated with optical fibre networks;3995128,75;3995128,75;H2020-ICT-2014-1;RIA;UNIVERSITY OF GLASGOW;UK;"IQE Silicon Compounds Ltd;Optocap Ltd;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;ALCATEL-LUCENT DEUTSCHLAND AG;COMPOUND SEMICONDUCTOR TECHNOLOGIES GLOBAL LIMITED;III-V LAB;UNIVERSIDADE DO ALGARVE;VIVID COMPONENTS LTD";"UK;FR;PT;DE"; 194550;648909;LEXICAL;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Lexical Acquisition Across Languages;1/09/2015;31/08/2020;;Due to the growing volume of textual information available in multiple languages, there is a great demand for Natural Language Processing (NLP) techniques that can automatically process and manage multi-lingual texts, supporting information access and communication in core areas of society (e.g. healthcare, business, science). Many NLP tasks and applications rely on task-specific lexicons (e.g. dictionaries, word classifications) for optimal performance. Recently, automatic acquisition of lexicons from relevant texts has proved a promising, cost-effective alternative to manual lexicography. It has the potential to considerably enhance the viability and portability of NLP technology both within and across languages. However, this approach has been explored for a very small number of resource-rich languages only, leaving the vast majority of worlds languages without useful technology. The ambitious goal of this project is to take research in lexical acquisition to the level where it can support multi-lingual NLP, involving also languages for which no parallel language resources (e.g. corpora, knowledge resources) are available. Building on an emerging line of research which uses mainly naturally occurring supervision (connections between languages) to guide cross-lingual NLP, we will develop a radically novel approach to lexical acquisition. This approach will transfer lexical knowledge from one language to another as well as will learn it simultaneously for a diverse set of languages using new methodology based on guiding joint learning and inference with rich knowledge about cross-lingual connections. We not only aim to create next generation lexical acquisition technology but also aim to take cross-lingual NLP a big step toward to the direction where it is no longer dependent on parallel resources. We will use our approach to support fundamental tasks and applications aimed at broadening the global reach of NLP to areas where it is now critically needed.;1989203;1989203;ERC-2014-CoG;ERC-COG;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194492;647281;SOLACYLIN;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;A preparative approach to geometric effects in innovative solar cell types based on a nanocylindrical structure;1/09/2015;31/08/2020;;"The ERC Consolidator Grant project SOLACYLIN aims at providing experimental insight into the function of 'third-generation' photovoltaic systems by generating materials stacks structured in a well-defined, accurately tunable, nanocylindrical geometry.
To this goal, we will develop and exploit advanced preparative methods based on two fundamental ingredients: (a) ordered 'anodic' porous oxides and (b) atomic layer deposition (ALD). The former solids will be generated as templates providing ordered arrays of straight, cyclindrical pores, the diameter and length of which can be varied between 20 nm and 300 nm and between 0.5 microns and 50 microns, respectively. The latter method will be used to coat the inner pore walls with one or several layers of the photovoltaic stack, each with a thickness set to values chosen between 1 nm and 30 nm.
We will invent and characterize novel surface reaction schemes for the deposition in ALD mode (from the gas phase and from solutions) of functional materials (doped semiconductors and intrinsic light absorbers) with tailored chemical and physical properties. We will investigate the experimental conditions in which they can be combined in a way that optimizes the quality of their interfaces.
Finally, we will quantify the electrical and photovoltaic performance of p-i-n junctions prepared with our methods. We will have the unique capability of describing in a systematic, accurate manner how the experimental photovoltaic parameters depend on the individual thicknesses of the individual layers and on the length of the cylinders. This direct experimental handle on the amount of light absorbed, on the one hand, and the charge carrier transport distances to the electrical contacts, on the other hand, will be correlated with the relevant material parameters (absorption coefficients, carrier mobilities). This information will unveil the phenomena limiting the efficiency of each type of solar cell, and suggest avenues to remedy them.";1938655;1938655;ERC-2014-CoG;ERC-COG;Friedrich-Alexander University (FAU) Erlangen-Nrnberg;DE;;; 194658;650426;ANAPRINT;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.2.";NMP-25-2014-1;H2020;Additive Printing for Cell-based Analysis;1/10/2014;31/03/2015;;"The Project will develop and commercialise the additive printing of cell-based analysis systems. The objective is to deliver consistent, scalable manufacturing of cell-based models used by multiple industry sectors to evaluate materials ranging from new drugs to healthcare products and functional foods. The target market is global and growing (CAGR 12%; estimated $4.2Bn in 2016). Additive printing will have positive disruptive impact, automating assay assembly and producing complex models needed by industry to improve the predictive value of cell-based analysis. Operational efficiencies and competitive pricing of printed cell products and services will win market share by making high-end analysis available to non-specialist users, whilst allowing wider integration of complex models into high-volume screening. The market advantage will be cost-effective testing and greater confidence in commercial decisions with strategic and financial impact.
The Phase 1 business plan will be built on market data, IP/technology audit and financial planning arising from 8 years successful ACS cell-based business. Phase 1 shall also prototype assays printed with iPSC-derived hepatocytes aimed at high-value hepatotoxicity testing; prototypes will be moved to TRL7, and in Phase 2 to market-ready TRL9 with client-reactive design aided by beta testing with opinion leaders. Technical innovation will use ACS core skills in human cell culture and build on commercial partnership with the UK National Centre for Additive Printing. Phase 2 will extend the technology platform to other cell models, expanding product range and commercial value. Post-project, these will be marketed and sold by expanding existing operations: initial hepatotoxicity sales alone are forecast at 0.6M one year post-launch (0.15% of global market). Market/sales extension to remote markets e.g. SE Asia will use JV companies or third-party distributors e.g. Japan. The Project requires 2.5 years and a budget of 2-2.5M.";71429;50000;H2020-SMEINST-1-2014;SME-1;AvantiCell Science Ltd;UK;;; 194381;645754;Vaccinesurvey;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Monitor population immunity against vaccine preventable diseases;1/01/2015;31/12/2018;;In the recent years an unprecedented effort has been made to increase the rates of childhood immunization in resource poor countries. This has translated into an increased number of children receiving vaccines and a parallel decrease in the rate of illnesses from vaccine preventable diseases. However, in some regions it has proven difficult to achieve optimal levels of immunization mainly because of issues concerning communication, management and poor utilization of resources. Recent studies have questioned the validity of available vaccine coverage data and the way they are collected. Currently, both the progress of the vaccination programs and indirectly the level of protection in a population are inferred on the basis of administrative records. This largely unverified information is also utilized as performance indicator to allocate funds from government and donor agencies. Such self-certification practice does not incentivize the optimization of resources while it has been increasingly questioned in terms of its validity and integrity. We propose to develop and validate an innovative technical solution based on an assay system that integrates multiplex capability and analytical performance, to simultaneously quantify antibody levels against the major vaccine components, with both automation and wireless connectivity to produce spatial-temporal co-ordinates of individual determinations. The multiplex capability will facilitate the analysis of cross coverage monitoring while generating reactivity profiles against the different vaccine components to discriminate vaccinated versus infected individuals. Spatial temporal co-ordinates of assay results will be used to generate interactive data sets for modeling changes in the age-specific risk of infection and the risk of outbreaks. The proposed system represents a formidable tool of unprecedented power to monitor the progress of different vaccination programs and experimentally validate record-based coverage data.;1053000;1053000;H2020-MSCA-RISE-2014;MSCA-RISE;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;"GENIALIS D.O.O;MICROTEST MATRICES LTD;POLO D' INNOVAZIONE DI GENOMICA, GENETICA E BIOLOGIA SCARL;UNIVERSITA DEGLI STUDI DI PERUGIA;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA";"SI;UK;IT"; 194336;645582;RoMaNS;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Robotic Manipulation for Nuclear Sort and Segregation;1/05/2015;30/04/2018;;"The RoMaNS (Robotic Manipulation for Nuclear Sort and Segregation) project will advance the state of the art in mixed autonomy for tele-manipulation, to solve a challenging and safety-critical sort and segregate industrial problem, driven by urgent market and societal needs.

Cleaning up the past half century of nuclear waste, in the UK alone (mostly at the Sellafield site), represents the largest environmental remediation project in the whole of Europe. Most EU countries face related challenges. Nuclear waste must be sorted and segregated, so that low-level waste is placed in low-level storage containers, rather than occupying extremely expensive and resource intensive high-level storage containers and facilities. Many older nuclear sites (>60 years in UK) contain large numbers of legacy storage containers, some of which have contents of mixed contamination levels, and sometimes unknown contents.

Several million of these legacy waste containers must now be cut open, investigated, and their contents sorted. This can only be done remotely using robots, because of the high levels of radioactive material. Current state-of-the-art practice in the industry, consists of simple tele-operation (e.g. by joystick or teach-pendant). Such an approach is not viable in the long-term, because it is prohibitively slow for processing the vast quantity of material required.

The project will:
1) Develop novel hardware and software solutions for advanced bi-lateral master-slave tele-operation.
2) Develop advanced autonomy methods for highly adaptive automatic grasping and manipulation actions.
3) Combine autonomy and tele-operation methods using state-of-the-art understanding of mixed initiative planning, variable autonomy and shared control approaches.
4) Deliver a TRL 6 demonstration in an industrial plant-representative environment at the UK National Nuclear Lab Workington test facility.";6377521,25;6377521;H2020-ICT-2014-1;RIA;THE UNIVERSITY OF BIRMINGHAM;UK;"COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;NATIONAL NUCLEAR LABORATORY LIMITED;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;TECHNISCHE UNIVERSITAT DARMSTADT";"FR;UK;DE"; 194345;645640;SCAFFY;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Bio-scaffold engineered device for brown adipose tissue regeneration;1/10/2015;30/09/2019;;"Obesity and cardio-metabolic disease represent major health problems with vast impacts on the European healthcare systems. Recent advances in tissue engineering and regenerative medicine can be used to design novel techniques aiming to boost human metabolism; thus being promising candidates for human metabolic disease treatment. However, the development of these techniques requires the creation of new technology and knowledge in chemistry, biomaterials, toxicology, physiology, molecular biology as well as business management and marketing. SMEs do not have the technical capabilities or the facilities to conduct R&D activities at the level of excellence required for such development. Academic institutions have the capacity and facilities to conduct research and design activities necessary to develop the concept into a market product. However, they do not have a viable supply chain to develop the prototype post project and to exploit the product in the market. To solve this intersectoral problem, the SCAFFY project will create an effective intersectoral co-operation between academia institutions and SMEs to advance the concept of bio-scaffold for brown adipose tissue regeneration. SCAFFY will put together knowledge, research expertise and resources from two large academic participants with business, market and commercialization experience from three SMEs to: i) ensure a high degree of collaboration between academic and industrial participants though Networking Activities, ii) go beyond the current state of the art though Researcher & Training Activities, iii) increase intersectoral transfer of knowledge though Workshop Activities, iv) ensure high level of innovation capacity though Innovation Activities, v) ensure communication to the scientific community and to the public though Dissemination and Outreach Activities.";864000;864000;H2020-MSCA-RISE-2014;MSCA-RISE;VRIJE UNIVERSITEIT BRUSSEL;BE;"IMEDICA SA;CHRISTOS PAPADOPOULOS & SIA O.E.;UNIVERSITA DEGLI STUDI DI BRESCIA;TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL;Histocell S.L.";"RO;EL;IT;ES"; 194383;645757;VIVOIMAG;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Multimodal imaging of the in vivo fate of bone transplants;1/06/2015;31/05/2019;;"The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration.
The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies.
A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.";472500;472500;H2020-MSCA-RISE-2014;MSCA-RISE;"""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS""""""";EL;"UNIVERSITE DE MONS;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;TEXNOLOGIKES LYSEIS BIOEKPOMPIS OE;BIOIMAG SOLUCIONES DE CONTRASTE SL;BONUS THERAPEUTIC LTD";"BE;ES;EL;IL"; 194429;646443;greenGain;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.3.1.;H2020-EU.3.3.2.";LCE-14-2014;H2020;Supporting Sustainable Energy Production from Biomass from Landscape Conservation and Maintenance Work;1/01/2015;31/12/2017;;"The aim of greenGain is to strengthen the energy use of regional and local biomass from the maintenance of areas and landscape elements, which is performed in the public interest. The scope of the biomass used, will be any material predominantly produced from nature conservation and landscape management, but not from energy-crops.

The main target groups are regional and local players, who are responsible for maintenance and conservation work and for the biomass residue management in their regions. Moreover, the focus will be on service providers - including farmers and forest owners, their associations, NGOs and energy providers and consumers.

The project will show strategies to build up reliable knowledge on local availability of these feedstocks and know-how on issues from logistics to storage and sustainable conversion pathways for the transformation of these feedstocks to renewable energy (heat and energy products). Furthermore political, legal and environmental aspects will be addressed in model regions. Awareness raising, governance and public acceptance actions will be focussed on. General guidelines will be prepared to guarantee a wide dissemination to other regions in the EU. The regional partners will be actively supported by Technical Partners for the project measures development and implementation.

As a CSA, the project focal point will be the exchange between the model regions and other similar relevant players in the EU, by good practice exchange, a topic-specific website, several workshops and educational site visits in different regions as well as other standard public relations activities.

The project team is carefully balanced between technical and scientific organisations and local demand side oriented players. Regions in northern Europe with a wide knowledge in this field are cooperating with European (south-west, middle, east) regions, having an untapped potential, that can be accessed through efficient knowledge transfer.";1829390,5;1829390,5;H2020-LCE-2014-3;CSA;Fachagentur Nachwachsende Rohstoffe e.V.;DE;"FUNDACION CIRCE CENTRO DE INVESTIGACION DE RECURSOS Y CONSUMOS ENERGETICOS;CZ BIOM - CESKE SDRUZENI PRO BIOMASU;COMUNITA MONTANA-ASSOCIAZIONE DEI COMUNI TRASIMENO-MEDIO TEVERE;SYNCOM FORSCHUNGS- UND ENTWICKLUNGSBERATUNG GMBH;SOGESCA s.r.l.;GRUPO DE ACCION LOCAL BAJO ARAGON-MATARRANA;LANDWIRTSCHAFTSKAMMER NIEDERSACHSEN";"ES;CZ;IT;DE"; 194256;644869;DICE;SIGNED;H2020-EU.2.1.1.3.;ICT-09-2014;H2020;Developing Data-Intensive Cloud Applications with Iterative Quality Enhancements;1/02/2015;31/01/2018;;"The rapid increase in demand for data-intensive applications capable of exploiting Big Data technologies such as Hadoop/MapReduce, NoSQL, cloud-based storage, and stream processing is creating massive growth opportunities for European independent software vendors (ISVs). However, developing software that meets the high-quality standards expected for business-critical cloud applications remains a barrier to this market for many small and medium ISVs, which often lack resources and expertise for advanced quality engineering.

DICE will tackle this challenge by defining a quality-driven development methodology and related tools that will markedly accelerate the development of business-critical data-intensive applications running on public or private clouds. Building on the principles of model-driven development (MDD) and on popular standards such as UML, MARTE and TOSCA, the project will first define a novel MDD methodology that can describe data and data-intensive technologies in cloud applications. A quality engineering toolchain offering simulation, verification, and numerical optimisation will leverage these extensions to drive the early design stages of the application development and guide software quality evolution.

DevOps-inspired methods for deployment, testing, continuous integration and monitoring feedback analysis will be used to accelerate the incorporation of quality in data-intensive cloud application both in public and private deployments, enhancing the capability of small and medium European ISVs to enter the Big Data market.";3954484;3954484;H2020-ICT-2014-1;RIA;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;"NETFECTIVE TECHNOLOGY SA;INSTITUTUL E-AUSTRIA TIMISOARA;UNIVERSIDAD DE ZARAGOZA;Flexiant Limited;XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO;POLITECNICO DI MILANO;PRODEVELOP;ATHENS TECHNOLOGY CENTER SA";"FR;RO;ES;UK;SI;IT;EL"; 194382;645756;GLYCANC;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer;1/07/2015;30/06/2019;;Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.;567000;567000;H2020-MSCA-RISE-2014;MSCA-RISE;WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER;DE;"FIDIA FARMACEUTICI SPA;SEMMELWEIS EGYETEM;Uppsala universitet;SEREND-IP GMBH;""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS"""""";UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE;UNIVERSITA DEGLI STUDI DELL'INSUBRIA;PANEPISTIMIO PATRON";"IT;HU;SE;DE;EL;FR"; 194409;646031;MATCH;SIGNED;H2020-EU.2.1.3.7.;NMP-33-2014;H2020;The Alliance for Materials way to the creation of the MATerials Common House - MATCH;1/01/2015;30/06/2017;;"'With this proposal, a qualified and assorted representative group of the European Materials community, intend to propose an activity for further boosting and reinforcing a concept launched by Alliance for Materials (A4M): the creation of a strong, sustainable, inclusive network where any European Materials players (from Industry, Research, University) could feel comfortable and can gain real value for her/his own interest and expectations as far as Materials R&D&I is concerned.
This partnership promotes the integration of concerted and strategic challenges of national, regional and European needs in the field.

The MATCH proposal is focused in 4 main targets, crucial for the promotion of European sustainable development and innovation actions, as anticipated by future challenges to:
the enlargement and effective improvement within the existing Materials network at EU level;
the multidisciplinary connection of Materials to a large number of fields relevant for European growth and where concerted management actions are needed;
the integration with existing and/or promotion of new Materials networks at National and Inter/Regional levels;
the integration of EU and national and regional networks in a sustainable (long-lasting) effectively aligned network hubs.

MATCH foresees the establishment of comprehensive networks focusing on complementary stakeholder areas to enable promotion of connections between the scientific creativity represented by academia and the enterprises to focus on market needs.

As a result of the MATCH project any organisation interested in materials research in Europe will have a single reference network through which to obtain information, contacts and guidance in an efficient and transparent way. Established and well-connected material research stakeholders will be able to intensify their activities and extend their collaborative activities at European level, realising the A4M concept for the 'The Materials Common House'.'";1999100,5;1999100;H2020-NMP-CSA-2014;CSA;CENTRO SVILUPPO MATERIALI SPA;IT;"FUNDACION TEKNIKER;Conseil Europen de l'Industrie Chimique;THE INSTITUTE OF MATERIALS, MINERALS AND MINING;EUROPEAN MATERIALS RESEARCH SOCIETY;LABORATORIO DI SCIENZE DELLA CITTADINANZA;FEDERATION DES ASSOCIATIONS EUROPEENNES DE MATERIAUX AISBL;ENERGY MATERIALS INDUSTRIAL RESEARCH INITIATIVE AISBL;SPINVERSE INNOVATION MANAGEMENT OY;FUNDACION TECNALIA RESEARCH & INNOVATION;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;NANOFUTURES ASBL;CONSIGLIO NAZIONALE DELLE RICERCHE;EUROPEAN APPAREL AND TEXTILE CONFEDERATION;CENTRE DE RECHERCHE PUBLIC HENRI TUDOR;UNINOVA-INSTITUTO DE DESENVOLVIMENTO DE NOVAS TECNOLOGIAS-ASSOCIACAO;LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;European Virtual Institute on Knowledge-based Multifunctional Materials AISBL";"ES;BE;UK;FR;IT;FI;DE;LU;PT"; 194535;648382;WILLOW;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;WIreLess LOWband communications: massive and ultra-reliable access;1/04/2015;31/03/2020;;"The overall objective of WILLOW is to make wireless communication a true commodity by enabling lowband communications: low-rate links for massive number of devices and ultra-reliable connectivity. This research effort is a major endeavour in the area of wireless communications, taking a different path from the mainstream research that aims at 4G, but faster. Lowband communication is the key to enabling new applications, such as massive sensing, ultra-reliable vehicular links and wireless cloud connectivity with guaranteed minimal rate. The research in WILLOW is centred on two fundamental issues. First, it is the efficient communication with short packets, in which the data size is comparable to the size of the metadata, i.e. control information, which is not the case in broadband communication. Communication of short packets that come from a massive number of devices and/or need to meet a latency constraint requires fundamental rethinking of the packet structure and the associated communication protocols. Second is the system architecture in which graceful rate degradation, low latency and massive access can exist simultaneously with the broadband services. The principles from WILLOW will be applied to: (a) clean-slate wireless systems; (b) reengineer existing wireless systems. Option (b) is unique to lowband communication that does not require high physical-layer speed, but can reuse the physical layer of an existing system and redefine the metadata/data relationship to achieve massive/ultra-reliable communication. WILLOW carries high risk by conjecturing that it is possible to support an unprecedented number of connected devices and wireless reliability levels. Considering the timeliness and the relevance, the strong track record of the PI and the rich wireless research environment at Aalborg University, WILLOW is poised to make a breakthrough towards lowband communications and create the technology that will enable a plethora of new wireless usage modes.";1994411,25;1994411,25;ERC-2014-CoG;ERC-COG;AALBORG UNIVERSITET;DK;;; 194477;646951;Euler systems;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Euler systems and the Birch--Swinnerton-Dyer conjecture;1/07/2015;30/06/2020;;"The Birch--Swinnerton-Dyer conjecture, one of the Millennium Prize Problems, is one of the central unsolved problems in mathematics. It predicts a relation between the arithmetic of an elliptic curve and the properties of the L-function of the elliptic curve. Some special cases of the conjecture were proven by Kolyvagin; the main ingredient in his proof is an algebraic construction called an Euler system. Even though Euler systems are extremely powerful tools, so far only five examples are known to exist. I propose to construct several new examples of Euler systems, in order to prove new cases of the Birch--Swinnerton-Dyer conjecture. In particular, I believe the following theorem to be within reach:

Let A be either a modular elliptic curve over a (real or imaginary) quadratic number field, or a modular abelian surface over the rational numbers. If the L-value L(A, 1) is non-zero, then the Mordell--Weil group of A is finite (i.e. the Birch--Swinnerton-Dyer conjecture holds for A).";1070473;1070473;ERC-2014-CoG;ERC-COG;UNIVERSITY COLLEGE LONDON;UK;;; 194366;645701;GoMyTri;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Golden Mycological Triangle joining forces to exploit mycological biodiversity for novel anti-infectives and other beneficial metabolites;1/01/2015;31/12/2018;;"The proposed project aims at the intensification of cooperations between research infrastructure organisations in German, the Netherlands and Thailand that are recognised internationally as strongholds in mycological, biotechnological and microbiological research. The cooperation is intended to explore the mycological and microbiological biodiversity of Europe and Southeast Asia, in particular with regard to the search for the badly needed new antibiotics and other biologically active substances.
The working plan includes activities such as the systematic exploration of fungal biodiversity by using modern molecular phylogenetic and chemotaxonomic techniques, as well as genome sequencing, in conjunction with classical microbiology.
The focus of the research will be set on endophytes (in particular, Xylariaceae and Botryosphaeriaceae), invertebrate-associated ascomycetes (Cordycipitaceae), and marine fungi and fungal-like organisms, respectively. In addition, some basidiomycete cultures will also be studied.
Between the participating partners already exist very good personal contacts and smaller research collaborations, which will be intensified in the context of the proposed project. Several staff exchanges and workshops are planned, which should allow the partners to further increase and optimise their interactions and to attain interdisciplinary skills.
In the medium term the project is aimed at attaining an internationally visible strategic cooperation, including other departments of the institutions involved.";333000;333000;H2020-MSCA-RISE-2014;MSCA-RISE;HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH;DE;KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW;NL; 194330;645500;Film265;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Improving European VoD Creative Industry with High Efficiency Video Delivery;1/01/2015;30/06/2016;;"Film265 delivers a comprehensive approach to support European small and medium VoD services with the most innovative technology in video delivery. It aims at providing them with the technological edge needed to compete in the international market of film distribution in the internet. The core of Film265 is to adapt a HEVC/H.265 video codec for VoD scenarios, including a decoder integrated into a video player and an encoder integrated into a transcoding application in the cloud. This development will be supported by a comparison of HEVC/H.265 with current solutions that uses H.264/AVC for full length real-life film material.

In order to assess feedback on the user demands and needs of the resulting video playouts Film265 will develop statistic tools that allow to determine the Quality of Experience by measuring buffering times, performance, delivery rate, the time watched etc. The tool will mainly consist of a plugin and a player that can be used by any VoD service around the globe.

Finally, in order to create a fully market-ready solution, we will create APIs that allow all relevant industry participants to make use of what we have developed.

The consortium consists of one university: TU Berlin (Germany), and three SMES: Reelport (France/Germany), Cinando (France) and LevelK (Denmark). TU Berlin (AES group) has an extensive experience on efficient implementations of video codecs, Reelport is a VoD provider for film festivals and other film-related projects. Cinando handles the market of the Cannes FIlm Festival, and LevelK is a Danish film distributor using VoD technologies. TU Berlin will provide the new video codec; Reelport its existing PicurePipe solution cloud encoding solution, and the new quality analysis tool; and Cinando and LevelK will integrate the new technologies into their VoD solutions, and will provide feedback about the efficiency and quality obtained by using the new technologies.";1131934,75;908851;H2020-ICT-2014-1;IA;TECHNISCHE UNIVERSITAET BERLIN;DE;"reelport GmbH;LEVELK APS;SOCIETE DE GESTION D'OPERATIONS COMMERCIALES POUR LE FESTIVAL INTERNATIONAL DU FILM";"DE;DK;FR"; 194643;650029;TAIPI;SIGNED;H2020-EU.1.2.3.;FETFLAG-2-2014;H2020;Tools and Actions for Impact Assessment and Policy makers Information;1/01/2015;31/12/2017;;"TAIPI, Tools and Actions for Impact Assessment and Policy makers Information, is a CSA proposal to the Policy environment for FET Flagships topic of the call H2020-FETFLAG-2014. TAIPI addresses the scope of the this topic by undertaking actions related to: (i) Assessing the impacts of FET Flagship initiatives, including through metrics and indicators; (ii) Collection of information need for policy making, e.g. through consultation actions and surveys. The general objective of TAIPI is to support and strengthen the FET Flagship Initiative and the two selected Flagships. Specific objectives of TAIPI are: (i) To develop assessment methodologies along with the required toolkits which will be applied respectively to HBP and Graphene Flagships, (ii) To carry out the impact assessment of both Flagships and the Flagship policy by applying the specifically developed methodology and tools, (iii) To collect and provide information for policy makers and funding organizations participating to Flagships initiative, (iv) To transfer to the Flagships these developed toolkits, and to enable them to use these tools after the end of the CSA, thus ensuring the sustainability of the project activities. TAIPI is composed of 5 work packages: WP1 Management, WP2 Development of methodology, WP3 Impact assessment, WP4 Support to policy makers, WP5 Dissemination. TAIPI will assess the impacts of HBP and Graphene, enhance the flow of information from the Flagships towards policy makers, relevant stakeholders and wider public, improve the understanding of the impacts of the Flagships on science, technology, economy and society and contribute to create a stable and structured environment for the benefit of the FET Flagships. The environment created by TAIPI will thus benefit to the Flagships, allowing them to concentrate on the fields where they bring the highest added value to their stakeholders while they rely on up-to-date tools, developed by TAIPI, to monitor in real time their impacts.";873442,5;799837,5;H2020-FETFLAG-2014;CSA;ERDYN CONSULTANTS;FR;"ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;RISE RESEARCH INSTITUTES OF SWEDEN AB;ZENTRUM FUR SOZIALE INNOVATION GMBH;AGENCE NATIONALE DE LA RECHERCHE";"CH;SE;AT;FR"; 194339;645634;INEXCA;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Excellent research and expertise of quality of cancer care by internationally trained staff;1/03/2015;28/02/2019;;"There is an international imperative to improve healthcare through health service research, including nursing research and new innovations. This EU-RISE project Excellent research and expertise of quality of cancer care by internationally trained staff (INEXCA) aims to utilize expertise across the globe to improve research, researcher training and care of cancer patients, family caregivers and patient and public involvement through international and intersectoral collaboration and staff exchange. The ultimate objectives are to create innovative opportunities to improve research and researchers skills and increase knowledge transfer from research to practice and business. The participants in the project representing academic, non-academic and clinical settings as well as information technology industry and health-related business experts from Belgium, Denmark, Finland, Italy, Great Britain and United States of America have enormous and interdisciplinary competences of their specializing areas in research methodology, quality of care, cancer care, patient involvement, family care givers and information technology in academic, non-academic and clinical settings. The participating organizations will bring their best know-how through staffs secondments, workshops, training courses, conferences, publications and other activities. An innovative ICT platform will be developed for sharing information and knowledge. In total, 34 academic and non-academic staff members will be involved in this INEXCA project for 263 months. The participants synergies and complementarities from different disciplines, experiences, methodological advancements as well as clinical practice will be fully in use. The planned secondments will offer the best opportunity to get the best outcomes for patients, families, EU citizens as well as researchers.
Descriptors: HEALTH SERVICES, HEALTH CARE RESEARCH";913500;913500;H2020-MSCA-RISE-2014;MSCA-RISE;ITA-SUOMEN YLIOPISTO;FI;"CEREF SRL;SYDDANSK UNIVERSITET;POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA;UNIVERSITY OF SURREY;SENSOFTIA OY;KATHOLIEKE UNIVERSITEIT LEUVEN";"IT;DK;FI;UK;BE"; 194299;645239;SocketMaster;SIGNED;H2020-EU.2.1.1.1.;ICT-02-2014;H2020;Development of a Master Socket for optimised design of prosthetic socket for lower limb amputees;1/02/2015;31/01/2018;;The function of a lower limb prosthetic is highly dependent upon the characteristics and anatomical profile of the residual limb. This is unique to each individual and changes depending on the activities being engaged in by the amputee. A poorly fitting prosthetic socket can cause significant trauma so it is important to consider how to optimise the fit to maximise the amputee's comfort whilst wearing the limb prosthesis. Current practice in designing a prosthetic socket is time-consuming, and is highly dependent on the experience of the prosthetist. The SocketMaster project aims to integrate micro electronic, mechanical (pressure and acceleration), fluidic biomechanical and moisture sensors into a Master Socket which can help prosthetists to achieve fast customised design and manufacturing of prosthetic sockets for lower limb (trans-femoral and trans-tibial) amputees. Firstly, existing micro sensors such as piezoelectric, MEMS based pressure sensors will be adapted or developed so that pressure distributions within the interface between the residual limb and the socket can be measured. Secondly, a Master Socket will be built by assembling the sensor system in a rigid hosting socket in such a way that the sensors' positions can be adjusted to achieve a comfortable configuration for the patient. The pressure distributions at typical activities of a patient will be used to optimise the socket design to maximise the patients comfort. The digital 3D data of the optimised socket design can be fed into a rapid prototyping machine for fast fabrication. Thirdly, clinical trials will be carried out to validate the Master Socket. It is envisaged that SocketMaster will enable same day socket fabrication with optimised quality, and the fit and function of the prosthetic socket will be less dependent on the skills of the prosthetist.;3950085;3950084;H2020-ICT-2014-1;RIA;TWI LIMITED;UK;"SENSING FUTURE TECHNOLOGIES LDA;POLKOM BADANIA SP ZOO;UNIVERSITY OF SURREY;VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI;HUGH STEEPER LIMITED;INNORA PROIGMENA TECHNOLOGIKA SYSTIMATA KAI YPIRESIES AE;PROTOLAB SRL;FONDAZIONE BRUNO KESSLER";"PT;PL;UK;IT;EL"; 194367;645704;SUPERCONCRETE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;SUstainability-driven international/intersectoral Partnership for Education and Research on modelling next generation CONCRETE;1/07/2015;30/06/2019;;"SUPERCONCRETE is a synergetic cross-disciplinary international/intersectoral project addressing theoretical models for next-generation concretes, characterised by a significant sustainability enhancement for the construction industry.

Three advanced concrete classes (CCs) are selected which represent the projects key research lines:
- Low-Carbon Concrete (LCC), characterised by non-conventional constituents, often derived from recycling industrial waste or by-products;
- High-Class Concrete (HCC), encompassing materials with enhanced performance in strength, durability;
- Fibre-reinforced Cementitious Composites (FCC), with special features on fibre/textile reinforcement and matrix improvement.

Developing synergetic through-life multi-scale models for these novel materials is the key objective of the SUPERCONCRETE project. Particularly, three transversal modelling issues (MIs) are considered:
- Rheology and Early age, dealing with the various physical and coupled thermo-hygro-chemical phenomena taking place in the first hours after mixing;
- Hardened state and service life, approached by constitutive modelling intended at predicting the instantaneous and long-term behaviour, for both service and ultimate conditions;
- Extreme conditions, based on constitutive theories capable of simulating the response under fire and high temperature exposure.

Each CC and MI is covered by one participant and the interactions among them is based on a matrix-like organisational approach aiming at achieving a true synergistic collaboration among those with specific CC knowledge and the ones bringing in transversal competences on MIs. A further cross-cutting objective aims at defining a Sustainability Index, based on its constituents and processes requested for each CC.

SUPERCONCRETEs final deliverables will be 1) a joint international course on sustainable concretes with 2) an underlying textbook and 3) a web-based platform for interacting with students and practitioners.";504000;468000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DEGLI STUDI DI SALERNO;IT;"UNIVERSIDADE DO MINHO;FUNDACION TECNALIA RESEARCH & INNOVATION;TECHNISCHE UNIVERSITEIT DELFT;TECHNISCHE UNIVERSITAT DARMSTADT;GESELLSCHAFT FUER MATERIALFORSCHUNG UND PRUEFUNGSANSTALT FUER DAS BAUWESEN LEIPZIG MBH";"PT;ES;NL;DE"; 194414;646122;MACIVIVA;SIGNED;H2020-EU.2.1.2.1.;NMP-08-2014;H2020;MAnufacturing process for Cold-chain Independent VIrosome-based VAccines;4/05/2015;3/11/2018;;"MACIVIVA is a highly interdisciplinary consortium among well established and innovative SMEs with scientific excellence and complementary industrial world-leading experts with unique expertise and know-how in virosome technology, spray and freeze drying, large scale manufacturing and packaging. MACIVIVA will pave the path to other large scale thermostable nanopharmaceuticals products for therapeutic and prophylactic vaccines and other potential applications for direct application by non-invasive routes.
Liquid products are inherently prone to physical and/or chemical modifications and degradations. Solid vaccine dosage formats (e.g. powder) may prevent molecular motion and shear-induced degradation, and slow down degradation involving water and oxygen radicals, resulting in improved stability and enhanced shelf-life of vaccines. The cold chain storage is still fundamental for preserving the bioactivity of most liquid and freeze-dried vaccines, and a reconstitution step prior to administration is required for freeze dried vaccines that are usually administered intramuscularly or subcutaneously. These reconstituted freeze dried vaccines harbor important instability and must be used within hours and kept refrigerated. Because most liquid and reconstituted freeze-dried vaccines are susceptible to degradations, it may affect the immunological properties of the immunogens, with unwanted immune responses or insufficient immune protection.
For addressing liquid virosome-based vaccine instability and improving their shelf-life outside the cold chain, MACIVIVA will explore new galenic vaccine formulations through careful screening of excipients, stabilization and drying methods for generating new vaccine solid forms that can be easily self-administered. Robust universal manufacturing processes for upscale production of virosome dried powder for the non-invasive intranasal, oral and sublingual routes should be achieved by month 42.";8438905,63;5338886,88;H2020-NMP-PILOTS-2014;RIA;MYMETICS BV;NL;"CATALENT U.K. SWINDON ZYDIS LIMITED;UPPERTON LIMITED;MYMETICS SA;BACHEM AG;CHIMERA BIOTEC GMBH";"UK;CH;DE"; 194320;645403;RobDREAM;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Optimising Robot Performance while Dreaming;1/02/2015;31/01/2018;;"Sleep! For hominids and most other mammals sleep means more than regeneration. Sleep positively affects working memory, which in turn improves higher-level cognitive functions such as decision making and reasoning. This is the inspiration of RobDREAM! What if robots could also improve their capabilities in their inactive phases by processing experiences made during the working day and by exploring or dreaming of possible future situations and how to solve them best?
In RobDREAM we will improve industrial mobile manipulators perception, navigation and manipulation and grasping capabilities by automatic optimization of parameters, strategies and selection of tools within a portfolio of key algorithms for perception, navigation and manipulation and grasping, by means of learning and simulation, and through use case driven evaluation. As a result, mobile manipulation systems will adapt more quickly to new tasks, jobs, parts, areas of operation and various other constraints.
From a scientific perspective the RobDREAM robots will feature increased adaptability, dependability, flexibility, configurability, decisional autonomy, as well as improved abilities in perception, interaction manipulation and motion. The technology readiness level (TRL) of the related key technologies will be increased by means of frequent and iterative real-world testing, validation and improvement phases from the very beginning of the project.
From an economic perspective the Quality of Service and the Overall Equipment Efficiency will increase, while at the same time the Total Cost of Ownership for setup, programming and parameter tuning will decrease. These advantages will support the competitiveness of Europe's manufacturing sector, in particular in SME-like settings with higher product variety and smaller lot-sizes. They also support the head start of technology providers adopting RobDREAMs technologies to conquer market shares in industrial and professional service robotics.";5401911;5401911;H2020-ICT-2014-1;RIA;KUKA ROBOTER GMBH;DE;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;KUNGLIGA TEKNISKA HOEGSKOLAN;FUNDACION TECNALIA RESEARCH & INNOVATION;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN;ALBERT-LUDWIGS-UNIVERSITAET FREIBURG;Convergent Information Technologies GmbH";"DE;SE;ES;AT"; 194603;649666;EPC_PLUS;SIGNED;H2020-EU.3.3.7.;EE-21-2014;H2020;Energy Performance Contracting Plus;1/03/2015;28/02/2018;;"Energy Performance Contracting (EPC) is generally looked upon favourably, but its implementation can be complicated and lengthy. The reason lies mainly in the procurement law provisions and the long-term and complex contracts, which impede a real breakthrough in the spread of the EPC methodology. The other main barriers for the implementation of EPC in SMEs are:

The transaction costs for procuring energy services are too high
Investments and project sizes are too small
It is difficult to obtain financing for such small projects
High costs for guarantees, measurement and verification procedures

The ultimate goal of the EPC\ project is to reduce transaction costs of energy service packages drastically so that smaller investments and projects in SMEs become possible for companies offering energy services. This can only happen if both the technical solutions as well as the contractual issues of energy services are highly standardized. The energy services offered can be either partly or wholly financed with innovative financing solutions, or may be more service-oriented solutions with guaranteed energy performances.

The major outputs of the project include: (1) the development of commercial, standardized energy service packages for SMEs in each participant country. Each participant country will develop energy service packages that suit the specific and particular requirements of their country. These will include a standardized technical solution for a specific market sector, a model contract and, where possible, a financing solution. (2) the implementation of pilot projects for the EPC\ packages in each participant country (3) the set-up and management of clusters of companies (SPINS) in each participant countries. These clusters will offer energy services to the SME market, (4) the training of these clusters of companies in each participant country and (4) the development of an international e-market for energy service providers.";1486015;1486014,75;H2020-EE-2014-3-MarketUptake;CSA;CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;EL;"SEVEN STREDISKO PRO EFEKTIVNI VYUZIVANI ENERGIE O.P.S.;E7 ENERGIE MARKT ANALYSE;GRAZER ENERGIEAGENTUR GMBH;INSTITUT JOZEF STEFAN;INSTITUTO DE SISTEMAS E ROBOTICA-ASSOCIACAO;HELESCO ENERGY SERVICES SA;TIPPERARY ENERGY AGENCY LIMITED;ARBEITSGEMEINSCHAFT ASEW c/o VKU;FACTOR 4 BVBA;ESCO ITALIA SRL;SDRUZHENIE CHERNOMORSKI IZSLEDOVATELSKI ENERGIEN TSENTAR;ESCAN SL";"CZ;AT;SI;PT;EL;IE;DE;BE;IT;BG;ES"; 194368;645705;DECADE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Deploying High Capacity Dense Small Cell Heterogeneous Networks;1/08/2015;31/07/2019;;"Broadband mobile networks are experiencing exponential traffic growth. It is predicted that this trend will continue in the next five to ten years with an estimated compound annual growth rate of 0.6 to 1.0. Hence the traffic (mostly data) carried by a mobile operators network in 2022 could be over 1000 times of that in 2012. This traffic growth presents a huge challenge to both the mobile industry and to academic researchers.

Along with increased spectrum efficiency, spectrum bandwidth expansion and traffic offloading through WiFi, small cell deployment is regarded as one of the most promising ways to meet the use of broadband mobile service in both outdoor and in particular indoor scenarios in the next decade. The deployment of small cells in a macrocell coverage area leads to a multi-tier heterogeneous network (HetNet), in which a mix of access node types, such as macrocell, femtocell and relay, will co-exist. Despite the current research and development on small cell/HetNet from both industry and academia, there are still many challenges to be addressed and questions to be answered for successful small cell and HetNet deployment. These challenges range from the lack of fundamental understanding of HetNet network capacity to the need of Radio Access Network (RAN) Planning and Optimisation (PO) tool for HetNet deployment involving both indoor and outdoor scenarios.

The DECADE project adopts the scheme of Research and Innovation Staff Exchange (RISE), with the effect of inter-sectorial efforts and knowledge integration to tackle the challenges in HetNet planning and optimization. The research consists in fundamental capacity analysis, system modeling, algorithm development, and performance engineering for HetNets. In addition, DECADE serves as a solid platform to promote long-term collaboration between academia and industry collaboration in a rapidly evolving area of Information and Communication Technologies (ICT) in Europe.";634500;634500;H2020-MSCA-RISE-2014;MSCA-RISE;LINKOPINGS UNIVERSITET;SE;"Ranplan Wireless Network Design Ltd;IQUADRAT INFORMATICA SL;THE UNIVERSITY OF SHEFFIELD";"UK;ES"; 194395;645809;RINEA;SIGNED;H2020-EU.3.6.;INT-02-2014;H2020;Research and Innovation Support for Europe and Africa;1/03/2015;28/02/2018;;"In response to the present objectives of the EU-Africa partnership in science, technology and innovation, and addressing the STI priorities of the 2014 EU-Africa Summit, RINEA addresses three specific and complementary objectives by a range of targeted activities:
1. Strengthening the quality and quantity of partnerships between research and innovation actors in EU Member states, in Associated Countries and in countries in Africa through networking events between research and business communities, through proposing the elimination of cooperation obstacles and optimising framework conditions and through raising awareness and disseminate information of cooperation opportunities for research and innovation partnerships offered by H2020 and by other major programmes in Europe and Africa.
2. Encouraging transnational coordination of programmes and policies for international cooperation in STI for greater coherence, joint ownership and resource efficiency, through advancing the model established by ERAfrica for jointly owned EU-Africa funding instruments for STI cooperation and through facilitating the launch and the management of calls for proposals around topics of mutual concern and relevance to the EU-Africa bi-regional partnership.
3. Supporting and enriching formal and informal processes of bi-regional STI policy dialogue between the EU and Africa through building wider understanding of the objectives and outcomes of formal bi-regional policy dialogue, through contributing to the evidence base for policy and decision making, including strategic priority setting, by the recognised governance structures of the EU-Africa STI partnership, e.g. HLPD, through supporting the implementation of outcomes of formal policy dialogue and through fostering exchange between formal and informal dialogue processes, and with relevant regional and sub-regional structures such as SFIC, AU technical committees and RECs.
RINEAs activities will build on recent and existing initiatives an";1927362,5;1927362,5;H2020-INT-INCO-2014;CSA;DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;DE;"JYVASKYLAN YLIOPISTO;MINISTERE DE LA RECHERCHE SCIENTIFIQUE ET DE L'INNOVATION;ASSOCIATION OF COMMONWEALTH UNIVERSITIES;MINISTERE DE L'ENSEIGNEMENT SUPERIEUR ET DE LA RECHERCHE SCIENTIFIQUE;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;National Office for Technology Acquisition and Promotion Act;DEPARTMENT OF SCIENCE AND TECHNOLOGY;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;AFRICAN UNION;MINISTRY OF EDUCATION;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"FI;BF;UK;DZ;EL;BI;NG;ZA;FR;ET;NA;PT"; 194520;648032;DBA;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Distributed Biological Algorithms;1/05/2015;30/04/2020;;This project proposes a new application for computational reasoning. More specifically, the purpose of this interdisciplinary project is to demonstrate the usefulness of an algorithmic perspective in studies of complex biological systems. We focus on the domain of collective behavior, and demonstrate the benefits of using techniques from the field of theoretical distributed computing in order to establish algorithmic insights regarding the behavior of biological ensembles. The project includes three related tasks, for which we have already obtained promising preliminary results. Each task contains a purely theoretical algorithmic component as well as one which integrates theoretical algorithmic studies with experiments. Most experiments are strategically designed by the PI based on computational insights, and are physically conducted by experimental biologists that have been carefully chosen by the PI. In turn, experimental outcomes will be theoretically analyzed via an algorithmic perspective. By this integration, we aim at deciphering how a biological individual (such as an ant) thinks, without having direct access to the neurological process within its brain, and how such limited individuals assemble into ensembles that appear to be far greater than the sum of their parts. The ultimate vision behind this project is to enable the formation of a new scientific field, called algorithmic biology, that bases biological studies on theoretical algorithmic insights.;1894947;1894947;ERC-2014-CoG;ERC-COG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;WEIZMANN INSTITUTE OF SCIENCE;IL; 194241;644732;COCOHA;SIGNED;H2020-EU.2.1.1.4.;ICT-22-2014;H2020;Cognitive Control of a Hearing Aid;1/01/2015;31/12/2018;;We propose to design a hearing aid system that can be mentally (cognitively) steered so as to allow a more natural communication for the hearing disabled, a population that forms over 7% of Europeans (50 million people). Hearing disabilities lead to a degraded quality of life, exclusion, and associated costs for society. Hearing aids (and cochlear implants), while effective in quiet, are still unreliable in noisy reverberant environments typical of realistic everyday life situations. Based on recent success in decoding non-invasive cortical recordings (EEG, MEG), and our multidisciplinary team (of engineers, neurophysiologists, psychophysicists, and audiologists), we propose to develop and implement algorithms to decode brain signals picked up by EEG electrodes to extract intention signals, and to match them to acoustic sources within the environment. These in turn will steer an acoustic beam-former towards the targeted speaker or sound source. We propose to implement the design within a real hearing aid, and to evaluate the outcome with normal and hearing impaired subjects. The results of this project will benefit hearing aid and cochlear-implant industries (well represented in Europe), and the end users who are the elderly and hearing impaired. It will also lead to increased scientific understanding and knowledge of attention mechanisms, and how they might be harnessed to control sensory inputs. We hope the results of this project will be a forerunner for broader applications of cognitive brain imaging to decipher and exploit human intentions in prosthetic sensory systems, especially given the increased availability, miniaturization, and affordability of EEG recording setups in scientific research and medical diagnostics.;3998125;3217500;H2020-ICT-2014-1;RIA;ECOLE NORMALE SUPERIEURE;FR;"OTICON A/S;UNIVERSITAET ZUERICH;DANMARKS TEKNISKE UNIVERSITET;UNIVERSITY COLLEGE LONDON";"DK;CH;UK"; 194354;645664;BESIIICGEM;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;An innovative Cylindrical Gas Electron Multiplier Inner Tracker for the BESIII Spectrometer;1/01/2015;31/12/2018;;"Inner Trackers (IT) are key detectors in Particle Physics experiments; excellent spatial resolution, radiation transparency and hardness, and operability under high occupancies are main requirements. While planar Gas Electron Multiplier (GEM) detectors are common in modern spectrometers, only one Cylindrical-GEMs (CGEM) detector has been produced up to now by the KLOE2 Collaboration and is being commissioned.
We aim to design, build and commission by 2017 a CGEM detector candidate to be the new IT of the BESIII spectrometer, hosted on BEPC2 in IHEP, Beijing; BESIII data taking will last until at least 2020. The IT itself will represent an evolution w.r.t. the state of the art of GEM (and CGEM) detectors, since the use of new kind of supports for the GEM foils will reduce the total radiation length of the detector and improve its tracking performance; an innovative design of the CGEM anode will allow for smaller capacitance and hence for bigger signals.
The relatively strong BESIII magnetic field requires a new analogue readout; full custom front-end electronics, including a dedicated ASIC, will be designed and produced for optimal data collection.
Specific software will be developed to first simulate, and then reconstruct the CGEM hits to detect reaction products.
Proper benchmark channels will be identified and investigated to maximise the outcome of the project.
An existing cloud infrastructure hosting a virtualised grid Tier-2 will be further expanded, providing an advanced environment optimised for scientific computing, suitable to investigate specific tools beyond commercial standards as well.
The project could significantly enhance the already established interaction between the participating EU and Chinese Institutions in BESIII, strengthening in particular those technological aspects remained so far in the background of the cooperation, and providing clear deliverables as the CGEM IT, the secondments being the key to knowledge transfer within the network.";1498500;1498500;H2020-MSCA-RISE-2014;MSCA-RISE;ISTITUTO NAZIONALE DI FISICA NUCLEARE;IT;"Johannes Gutenberg Universitaet Mainz;Uppsala universitet";"DE;SE"; 194315;645372;ARCADIA;SIGNED;H2020-EU.2.1.1.3.;ICT-09-2014;H2020;A NOVEL RECONFIGURABLE BY DESIGN HIGHLY DISTRIBUTED APPLICATIONS DEVELOPMENT PARADIGM OVER PROGRAMMABLE INFRASTRUCTURE;1/01/2015;31/12/2017;;Given the inability of Highly-Distributed-Application-Developers to foresee the changes as well as the heterogeneity on the underlying infrastructure, it is considerable crucial the design and development of novel software paradigms that facilitate application developers to take advantage of the emerging programmability of the underlying infrastructure and therefore develop Reconfigurable-by-Design applications. In parallel, it is crucial to design solutions that are scalable, support high performance, are resilient-to-failure and take into account the conditions of their runtime environment. Towards this direction, the ARCADIA project aims to design and validate a Novel Reconfigurable-By-Design Highly Distributed Applications Development Paradigm over Programmable Infrastructure. The proposed framework will rely on the development of an extensible Context Model which will be used by developers directly at the source-code level. Proper Context-Model will be assisted and validated by IDE-plugins (for many IDEs) in order to re-assure that the generated executable files contain meaningful semantics. According to ARCADIAs vision, the generated executables should be on-boarded by a Smart Controller which will undertake the tasks of translating annotations to optimal infrastructural configuration. Such a controller will enforce an optimal configuration to the registered programmable resources and will pro-actively adjust the configuration plan based on the Infrastructural State and the Application State. The Context-Model and the aforementioned ARCADIA toolset will be complemented by a Development Methodology that will assure that developed Highly Distributed Applications are Reconfigurable-By-Design. The framework is planned to be validated and evaluated on three use cases that will be deployed over testbeds that host heterogeneous programmable infrastructure.;3543864;3543864;H2020-ICT-2014-1;RIA;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;"WINGS ICT SOLUTIONS INFORMATION & COMMUNICATION TECHNOLOGIES EPE;MAGGIOLI SPA;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;STIFTELSEN SINTEF;GIOUMPITEK MELETI SCHEDIASMOS YLOPOIISI KAI POLISI ERGON PLIROFORIKIS ETAIREIA PERIORISMENIS EFTHYNIS;TECHNISCHE UNIVERSITAET BERLIN;UNIVERZA V LJUBLJANI;ADITESS ADVANCED INTEGRATED TECHNOLOGY SOLUTIONS & SERVICES LTD";"EL;IT;NO;DE;SI;CY"; 194462;646623;NEUCOS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Neutrinos and the origin of the cosmic rays;1/09/2015;31/08/2020;;"The discovery of cosmic neutrinos is one of the major breakthroughs in science in the year 2013. These neutrinos are expected to point back to the origin of the cosmic rays, which are produced in the most powerful accelerators in the universe. In order to solve the puzzle where the highest energetic neutrinos and cosmic rays come from, the key information could be the composition of the observed cosmic ray flux. The question critical for the future development of high-energy astrophysics is especially how heavier nuclei can be accelerated and escape from the sources, such as gamma-ray bursts or active galactic nuclei, without disintegration, or what the consequences for the neutrino fluxes and cosmic ray compositions at the sources are. Neutrinos, on the other hand, may be good for surprises, such as new physics only detectable at extreme energies, distances, or densities. In addition, the possibility to measure neutrino properties in neutrino telescopes has been emerging, either using astrophysical or atmospheric neutrino fluxes, which means that the border line between neutrino physics and astrophysics applications in these experiments fades.
The key idea of this proposal is therefore to combine the expertise from astrophysics and particle physics in a multi-disciplinary working group 1) to study the effect of heavy nuclei on the source fluxes from multiple messengers, such as a neutrinos, cosmic rays, and gamma-rays, using efficient descriptions for the radiation processes and particle interactions, and 2) to optimize future experiment infrastructure in ice and sea water for both astro- and particle physics applications. The key goals are to eventually identify the origin of the cosmic rays and cosmic neutrinos, and to solve the open questions in particle physics, such as neutrino mass hierarchy and leptonic CP violation.";1746000;1746000;ERC-2014-CoG;ERC-COG;STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY;DE;;; 194505;647514;HISTROOTS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;HISTORICAL ROOTS OF CONFLICT AND DEVELOPMENT: FROM PREHISTORY TO THE COLONIZATION EXPERIENCE;1/05/2015;30/04/2020;;"I plan to study the effect of history on conflict and economic development with two historical microscopes.
Following the lead of the new institutional economics, part of the literature argues that institutions cause differences in productivity and factor endowments which, in turn, explain economic development. An alternative view assumes that human capital shapes institutional changes and, therefore, institutions are endogenous. In the first part of the project, which is the core of the research proposal, I will try to move one step further in this debate by taking an approach that uses administrative data on the first colonizers of Latin America. The data contain some personal characteristics on each of the settlers from 1492 to 1599 (town of origin in Spain, occupation, education, city of arrival in the Americas, etc). Using within-country analysis, since we have information on the precise destinations of the first pobladores (settlers), and the different institutional set-ups during the first years of colonization for different geographical areas in Latin America, I will reexamine the issue of institutions versus human capital in the explanation of economic development and conflict. The institutions in the initial times of colonization were not the same in all the regions of Latin America and, in many cases, represented an evolution of pre-Colombian institutions. The new data allows also the analysis of the interaction between human capital and institutions in the initial times. In addition the migrations and the evolution of institutions during the first century of colonization provide also some guidance for the research on the sources of institutional persistence.
In the second part I plan to go further back in time to understand how very old conflicts influence current conflict. I will construct a dataset with the location of old conflicts using archaeological evidence to analyze the dynamics of conflict by regions in the very long run.";1699664;1699664;ERC-2014-CoG;ERC-COG;Universitat Pompeu Fabra;ES;;; 194351;645666;CRIC;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Cultural Narratives of Crisis and Renewal;1/01/2015;31/12/2018;;"The objective of the Cultural Narratives of Crisis and Renewal project is to examine cultural production and cultural practices in periods of societal crisis at the turn-of the 20th Century on both sides of the Atlantic. The overarching aim of the project is to investigate the role of cultural production, not just as a vehicle to elaborate cohesive narratives in moments of crisis, but as a space to create alternative imaginaries for social renewal. We need to explore the changing nature of our societies and the reconfiguration of regional and/or national cultural landscapes into globalized real (and virtual) spaces that erode the cultural frontiers of the nation-state.
The project aims to address the scarcity of scientific research on cultural narratives elaborated around conjunctures of crisis and renewal, from the 1970s transition to neoliberalism in Latin America, to the aftermath of the 2008 financial crisis in Spain. The analysis of cultural narratives and production in periods of societal crisis will lead us to identify underlying sets of values, beliefs, and practices: the way people think and act; who those people are and why they operate in a given cultural set (Cardoso and Jacobetty 2012).
The programme will bring together researchers specialized in Hispanic and Latin American culture from 4 universities in Europe (Newcastle University (UNEW), Amsterdam University (UVA), Universitat de Valncia (UV) and Universitat de Lleida (UDL)) and 4 universities in Latin America (Universidad Austral de Chile (UACH), Pontificia Universidad Catlica del Per (PUCP), Universidad Nacional de Crdoba (UNC: Argentina), and Universidad Nacional Tres de Febrero (UNTREF: Argentina)). The project will support international networking, high quality academic publications (including at least 3 edited volumes, and 6 collaborative articles in international peer-reviewed journals), and knowledge transfer through research and training events, conferences, and exhibitions.";1044000;1044000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;"UNIVERSIDAD DE LLEIDA;UNIVERSITAT DE VALENCIA;RIJKSUNIVERSITEIT GRONINGEN;UNIVERSITEIT VAN AMSTERDAM";"ES;NL"; 194379;645749;NEXT-3D;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Next generation of 3D multifunctional materials and coatings for biomedical applications;1/06/2015;31/05/2017;;NEXT-3D is an innovative European-Australian project that consists of 4 academic and 2 non-academic members. The research methodology is based on the multi-disciplinary and inter-sectorial collaboration among the network participants and focuses into main themes: 3D Printing, Enhance Coating, and medical translation with the main aim to develop the next generation of multifunctional 3D materials for orthopaedic and dental implants. Multifunctional materials with drug delivery properties and antibacterial properties are desirable by clinicians. These materials promote healing and can reduce and prevent from unexpected effects on patients. Research will be conducted following a multi- and inter-disciplinary research methodology designed to develop innovative biomedical materials using advanced processing technologies (3D laser printing and sintering) with market potential. The proposed research and innovative programme will lead to the advancement of knowledge in the field and to new materials with superior properties.;193500;193500;H2020-MSCA-RISE-2014;MSCA-RISE;THE UNIVERSITY OF BIRMINGHAM;UK;"ASSOCIATION DES AMIS DE LA MEDECINE SOCIALE;INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE";FR; 194305;645314;TOP HIT;SIGNED;H2020-EU.2.1.1.1.;ICT-02-2014;H2020;Transfer-print operations for heterogeneous integration;2/02/2015;1/02/2018;;"Smart systems technologies are evolving towards ever increasing functionality and miniaturisation through the heterogeneous integration of separate components. The ideal integration requires precision placement of multiple types of devices on a substrate to allow their inter-connection. We propose to solve this integration challenge through an exciting new technique called micro-Transfer-Printing (TP) where the essential materials or devices, with thicknesses of a few microns, are separated from their native substrates and are transferred in parallel to the new platform according to the desired positioning while achieving micron-scale placement accuracy. Sequential application of the process enables different components of different functionality to be manipulated in a highly flexible and programmable way making best use of the materials. The TOP HIT project will aggressively develop and validate the TP technology by integrating electronics and photonics components for the magnetic and communication industries. These serve as examples for the broad capability of the technology which is compatible with low-cost manufacturing.
We will develop On Head Microelectronics for data storage smart systems through the embedded integration of custom electronic circuits directly into the magnetic read-head. We will demonstrate TP as a scalable method for the integration of compound semiconductor based elements (lasers, detectors) with silicon photonics platforms demonstrating both a compact receiver circuit and a transceiver.
The partners in the TOP HIT consortium include international companies with extensive manufacturing capabilities, an SME, and two research institutes. The output of this project will help establish TP as a mainstream technology for heterogeneous integration, enabling manufacturing to be carried out in Europe through sales of equipment and through foundry services.

New more efficient smart products will emerge from the research carried out here.";5252637,75;5252637,75;H2020-ICT-2014-1;RIA;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;"SEAGATE TECHNOLOGY IRELAND;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;X-FAB MEMS FOUNDRY GmbH;X-CELEPRINT LIMITED;HUAWEI TECHNOLOGIES RESEARCH & DEVELOPMENT BELGIUM;THE CENTRE FOR INTEGRATED PHOTONICS LIMITED";"UK;BE;DE;IE"; 194353;645662;SMARCOAT;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Development of Smart Nano and Microcapsulated Sensing Coatings for improving of Material Durability/Performance;1/01/2015;31/12/2018;;"The proposal aims to develop an innovative approach to impart sensing functionality and detect substrate degradation. The degradation processes targeted will be corrosion of metallic substrates and mechanical damage by impact on fibre reinforced plastics and composites (FRP), used as structural components in the vehicle industry worldwide.
The innovative sensing materials are based on controlled release of active species, encapsulated in polymeric and inorganic capsules with sizes ranging from several micrometres down to the nanometre range. These will be designed and prepared in a way that responds to specific triggers associated with the nature of the degradation process. The functional materials will be subsequently incorporated as additives in organic and hybrid organic-inorganic coating matrices, or directly impregnated in the substrate (FRP). The goal is to get coatings capable of sensing substrate degradation at early stages, making maintenance operations cost-effective without jeopardizing safety.
The range of selected materials encloses systems conceptually designed to be prepared and tested for the first time at lab scale (high breakthrough at research level) and others already studied at lab scale with promising results and which can already be tested at pilot scale (high innovation level). Furthermore, the characterization encompasses lab-scale, cutting-edge technologies and modelling, as well as upscaling and industrial validation.
The consortium upon which the present proposal is set has strong knowledge and previous experience in the topics above presented, reflected upon previous participation in large FP7 EU-projects as well as on Marie Curie actions (IRSES). Therefore, part of the interdisciplinary exchanging network necessary to successfully achieve the objectives and allow a flow and sharing environment of people, knowledge and methods has already been tested in previous projects with positive results.";900000;900000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSIDADE DE AVEIRO;PT;"LATVIJAS UNIVERSITATES POLIMERU MEHANIKAS INSTITUTS;SYNPO AKCIOVA SPOLECNOST;HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH;SMALLMATEK - SMALL MATERIALS AND TECHNOLOGIES LDA";"LV;CZ;DE;PT"; 194284;645119;TAPPS;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Trusted Apps for open CPS;1/01/2015;31/12/2017;;"Open and smart cyber-physical systems (CPS) are considered to be the next revolution in ICT with enormous economic potential enabling novel business models for integrated services and products. In many areas of CPS devices, there is a strong trend towards open systems, which can be extended during operation instantly adding functionalities on demand. The main goal of the TAPPS (Trusted Apps for open CPS) project is the development of a platform for CPS Apps, which can also access and modify device internals. Therefore, the solution will address all necessary layers from hardware over software to an app store concept always ensuring security and full real-time support for the applications. The extensibility and the pervasive trusted environment of TAPPS are important differentiators that will enable new market extensions to keep pace with user expectations and latest technology.

As current, rich execution platforms for apps are limited in security, the project will develop a parallel, real-time Trusted Execution Environment (TEE) for highly-trusted CPS Apps. The TEE is located separately from existing the execution environment inside the System Control Units and exploits functionalities provided by the novel hardware-, processor- and network-centric security mechanisms as well as a hypervisor for virtualization. Furthermore, TAPPS will provide and validate an end-to-end solution for development and deployment of trusted apps, including an App Store and a model-based tool chain for trusted application development including verification tools. This multi-level trusted Apps platform and tool chain are matured and validated in health and automotive application domains using industrial, realistic use cases paving the way for future exploitation in further demanding application domains.";3885484;3885484;H2020-ICT-2014-1;RIA;FORTISS GMBH;DE;"STMICROELECTRONICS GRENOBLE 2 SAS;CRP MECCANICA SRL;ACTILITY SAS;ENERGICA MOTOR COMPANY S.P.A.;FONDAZIONE CENTRO SAN RAFFAELE;VIRTUAL OPEN SYSTEMS SARL;TECHNOLOGICAL EDUCATIONAL INSTITUTE OF CRETE;TTTECH COMPUTERTECHNIK AG";"FR;IT;EL;AT"; 194628;649865;REFURB;SIGNED;H2020-EU.3.3.7.;EE-05-2014;H2020;REgional process innovations FOR Building renovation packages opening markets to zero energy renovations;1/04/2015;31/03/2018;;"As stated by the EC, renovation by the private housing sector towards increased energy efficiency is seriously lagging behind. As more than sufficient technological solutions are available, focus must be on removing non-technological barriers.

The main barriers relate to fragmentation of the renovation offers, resulting in inefficient or only partial solutions. In addition to financial restrictions and unclear benefits, house-owners do not have a structured way to obtain all the necessary information related to renovation measures.

One of the ways to solve this, is the use of 1-stop shop concept. Many initiatives have already been put into practice. Some of these projects were successful, but several were not. They often lack an understanding of the concerns and demands of the house-owners. REFURB 2.0 will tackle the complex interplay of these barriers through coordinated process organisation, innovation and optimization.

REFURB 2.0 will bridge the gap between supply and demand side by:
developing a holistic approach to the renovation process in which technology combinations trigger step-by-step deep energy renovation of existing, private residential buildings towards NZEB-standards.
accommodating the technology solutions to the decision-making psychology and language of residential house-owners; this will provide the drivers for empowerment and mobilisation of house-owners for deep renovation.
developing a quality and performance protocol to build trust on the demand side.

The above mentioned activities will result in dedicated renovation packages for different market segments and regions in Europe, starting with the private residential sector. A small scale pilot will be carried out in order to validate and demonstrate the REFURB 2.0 solution. This will be followed by a roll-out plan to stimulate EU wide uptake. In addition, a transferability plan will be established for other sectors, whereas the social housing sector will be the first follower.";2074875;2074875;H2020-EE-2014-3-MarketUptake;CSA;VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.;BE;"PROVINCIE FRYSLAN;CLEAN;Recticel N.V.;AALBORG UNIVERSITET;BAUVEREIN HALLE & LEUNA EG;RECTICEL BV;GEMEENTE LEEUWARDEN;BSC, POSLOVNO PODPORNI CENTER, DOO;BOUW FRANCIS BOSTOEN NV;ISW INSTITUT FUR STRUKTURPOLITIK UND WIRTSCHAFTSFORDERUNG GEMEINNUTZIGE GESELLSCHAFT MBH;PROJECT ZERO A/S;MITTETULUNDUSUHING TARTU REGIOONI ENERGIAAGENTUUR;INTERCOMMUNALE LEIEDAL;FUDURA BV";"NL;DK;BE;DE;SI;EE"; 194325;645471;DiasporaLink;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;DiasporaLink;1/02/2015;31/01/2019;;"DiasporaLink is a 4-year exchange program between 24 universities and research institutes representing EU, the Americas, Africa and Australia and will investigate, evaluate and facilitate transnational diaspora entrepreneurship, TDE as driver of development and wealth creation in countries of origin and residence.
The partners in DiasporaLink have together a unique possibility to have a substantial impact on a global, European and national level targeting different groups and stakeholders:
The international research community
Institutions and policy makers in the social, economic and development field
Diaspora organizations and communities
Media and press
This is underlined by the specific network of the partners
GEM Global Entrepreneurship Monitor
IMISCOE International Migration, Integration, Social Cohesion
International Council for Small Businesses
Swedish TDE network
Core tasks are:
Structure research on diaspora cross-border entrepreneurship in migration corridors
Create awareness among policy and decision makers of the potential of TDE through publications and a web-site
Build a IT-curricula for transnational entrepreneurship within and outside the universities
Build an ICT-platform for internal communication and for transnational team building
The exchange of staff is built around research in common WPs and around regular and touring workshops both internal and external.
The objective is to create a global, extended university network with the mission to monitor the entrepreneurship in migration corridors, define obstacles and support the corridor stakeholders with information and tuition.
Essential is close contacts with diaspora entrepreneurs and diaspora organizations are systematically approached through workshops and media, for involving diaspora organizations as active partners.";571500;571500;H2020-MSCA-RISE-2014;MSCA-RISE;ROSKILDE UNIVERSITET;DK;"SWEDISH ETHIOPIAN CHAMBER OF COMMERCE;INSTITIUID TEICNEOLAIOCHTA BHAILE ATHA CLIATH;STICHTING THE NETWORK UNIVERSITY;SYDDANSK UNIVERSITET;Uppsala universitet;INSTITUTO DE GEOGRAFIA E ORDENAMENTO DO TERRITORIO DA UNIVERSIDADE DELISBOA;Universitat Pompeu Fabra;UNIVERSITY OF EAST LONDON;THE UNIVERSITY OF BIRMINGHAM;GROUPE SUP DE CO MONTPELLIER;STOCKHOLMS UNIVERSITET;GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER;UNIVERSITY OF STRATHCLYDE";"SE;IE;NL;DK;PT;ES;UK;FR;DE"; 194588;649491;YMOBILITY;SIGNED;H2020-EU.3.6.;YOUNG-2-2014;H2020;Youth mobility: maximising opportunities for individuals, labour markets and regions in Europe;1/03/2015;28/02/2018;;"Research on international youth mobility has been fragmented, mostly based on relatively small samples and case studies. YMOBILITY develops a comprehensive research programme which addresses the following:
Identifying, and quantifying, the main types of international youth mobility in the EU, and their key characteristics. Particular attention will be given to differences between and within three main types: highly skilled, less skilled and students
Understanding what determines which individuals do and which do not participate in international mobility as personal and professional development strategies: their motives, migration channels and information sources
Analysing the individual outcomes in terms of both employability and careers (skills and competences) and non-economic terms (welfare and identities).
Analysing the territorial outcomes for the regions of both origin and destination, in economic, demographic and cultural terms
Differentiating between short-term and long-term outcomes, taking into account return migration and future intentions to migrate.
Identifying implications for policies in migration but also of education, the economy and housing
The research will utilise existing secondary data for the whole of the EU, but will mainly rely on primary quantitative data (large-scale surveys to be undertaken by polling agency) and qualitative data (interviews with migrants and returned migrants). The study will focus on 9 countries representing different contexts for youth mobility: Romania, Slovakia and Latvia as sources of emigration and return; the UK and Sweden as destinations for migrants; Germany, Italy, Ireland and Spain as both major destinations and countries of origin. The policy analysis will be informed by interviews undertaken with key informants, such as migrant associations and policy-makers. Experimental methods will be used to assess how individuals will respond to different scenarios of future economic and social change.";2450368;2450367,75;H2020-YOUNG-SOCIETY-2014;RIA;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA;IT;"UNIVERSIDAD DE ALMERIA;MALMOE HOEGSKOLA (MALMOE UNIVERSITY);UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;UNIVERSITATEA DIN BUCURESTI;PROGNOSTICKY USTAV SLOVENSKEJ AKADEMIE VIED;UNIVERSITY OF SURREY;UNIVERSITY OF SUSSEX;UNIVERSITAET BIELEFELD;LATVIJAS UNIVERSITATE";"ES;SE;IE;RO;SK;UK;DE;LV"; 194337;645648;Muscle stress relief;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Muscle Stress Relief: An integrated research program linking together basic research on secondary myopathies in stress states to innovative translation in applied myology.;1/03/2016;29/02/2020;;"A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in the developed countries. Clinical research on the mechanisms involved requires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with a leading team in the U.S. with expertise in the translation of muscle research into therapeutic interventions, and with one team from South Africa with cutting-edge expertise in the regulation of regenerative capacities in muscle.
Importantly, four SMEs will participate in this RISE network that provide expertise in early muscle disease detection, monitoring, and the developing preventive strategies: Their knowledge on muscle disease detection at early stages and their monitoring during interventions will promote translational innovation. To implement innovation and our joint research program, both early stage and advanced researchers will be seconded from the academic eight teams to these four SMEs and vice versa. Thereby, this RISE scheme will establish a long-term collaborative University-SME driven translational innovative research program innovation in our interdisciplinary field of growing socioeconomic medical importance.";1606500;1458000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITY OF ST MARK & ST JOHN;UK;"RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG;EUROPEAN MOLECULAR BIOLOGY LABORATORY;CHRISTOS PAPADOPOULOS & SIA O.E.;STICHTING VU;ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT;DLD GESELLSCHAFT FUR DIAGNOSTIKA UND MEDIZINISCHE GERATE MBH;IMMUNDIAGNOSTIK AG;THE UNIVERSITY OF LIVERPOOL;MYOMEDIX GMBH;TZARTOS - DIAGNOSIS & RESEARCH IN NEUROIMMUNOLOGY MEDICAL LIMITED LIABILITY COMPANY;FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS;UNIVERSITAT KONSTANZ;PANEPISTIMIO THESSALIAS;ASSOCIATION GENETHON";"DE;EL;NL;UK;IT;FR"; 194300;645241;TransFlexTeg;SIGNED;H2020-EU.2.1.1.1.;ICT-03-2014;H2020;Large area transparent thin film thermoelectric devices for smart window and flexible applications;1/01/2015;31/12/2018;;"The main objective is to develop an innovative large area distributed sensor network integrating transparent thin film thermoelectric devices and sensors for multifunctional smart windows and flexible high impact volume applications. Different breakthrough concepts are proposed: 1) large area high performance transparent thermoelectric thin films deposited on flexible substrates for thermal energy harvesting; 2) low cost high throughput thin film thermal sensors for thermal mapping and gesture sensing; 3) flexible smart windows and walls with energy harvesting, environmental sensing and wireless communication functionalities.
The developed technology aims to demonstrate the functionalities of a smart window able to measure air quality and environmental parameters such as temperature, sun radiation and humidity. The data is automatically collected and can be utilized for controlling heating, cooling and ventilation systems of indoors. Active radio interface enables long range communication and long term data collection with WiFi or a similar base station. The proposed concept of smart windows replaces several conventional sensors with a distributed sensor network that is integrated invisibly into windows. In addition to the power generated from the thermal energy harvesting, the thermoelectric elements (TE) are also used as temperature sensors that, while being distributed over large area, enable thermal mapping of the area instead of just one or a few values measured from particular points. This smart window can be produced on glass, but the final goal will be the fabrication on transparent flexible organic substrates using Roll to Roll Atomic Layer Deposition (R2R ALD), that can be fixed or retrofitted on existing windows or walls, which will significantly broaden the field of applications and improve business opportunities. High environmental impact is expected with savings of more than 25% of the electrical usage of residential homes and office buildings.";4091187,5;4091187,5;H2020-ICT-2014-1;RIA;UNINOVA-INSTITUTO DE DESENVOLVIMENTO DE NOVAS TECNOLOGIAS-ASSOCIACAO;PT;"SCIENCE TECHNOLOGY RESEARCH PARTNERS LIMITED;AGFA-GEVAERT N.V.;AALTO-KORKEAKOULUSAATIO;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;SOLEARTH LIMITED;PICOSUN OY;GRINP SRL;TEKNOLOGIAN TUTKIMUSKESKUS VTT;Teknologian tutkimuskeskus VTT Oy";"IE;BE;FI;FR;IT"; 194226;644632;MixedEmotions;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;Social Semantic Emotion Analysis for Innovative Multilingual Big Data Analytics Markets;1/04/2015;31/03/2017;;"MixedEmotions will develop innovative multilingual multi-modal Big Data analytics applications that will analyze a more complete emotional profile of user behavior using data from mixed input channels: multilingual text data sources, A/V signal input (multilingual speech, audio, video), social media (social network, comments), and structured data. Commercial applications (implemented as pilot projects) will be in Social TV, Brand Reputation Management and Call Centre Operations. Making sense of accumulated user interaction from different data sources, modalities and languages is challenging and has not yet been explored in fullness in an industrial context. Commercial solutions exist but do not address the multilingual aspect in a robust and large-scale setting and do not scale up to huge data volumes that need to be processed, or the integration of emotion analysis observations across data sources and/or modalities on a meaningful level. MixedEmotions will implement an integrated Big Linked Data platform for emotion analysis across heterogeneous data sources, different languages and modalities, building on existing state of the art tools, services and approaches that will enable the tracking of emotional aspects of user interaction and feedback on an entity level. The MixedEmotions platform will provide an integrated solution for: large-scale emotion analysis and fusion on heterogeneous, multilingual, text, speech, video and social media data streams, leveraging open access and proprietary data sources, and exploiting social context by leveraging social network graphs; semantic-level emotion information aggregation and integration through robust extraction of social semantic knowledge graphs for emotion analysis along multidimensional clusters.";3529617,14;3036910;H2020-ICT-2014-1;IA;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;"PARADIGMA DIGITAL SL;SINDICE LIMITED;MILLWARD BROWN CZECH REPUBLIC SRO;VYSOKE UCENI TECHNICKE V BRNE;DEUTSCHE WELLE;UNIVERSITAT PASSAU;EXPERT SYSTEM S.P.A.;PHONEXIA SRO;UNIVERSIDAD POLITECNICA DE MADRID";"ES;IE;CZ;DE;IT"; 194399;645860;ROUTE-TO-PA;SIGNED;H2020-EU.3.6.;INSO-1-2014;H2020;Raising Open and User-friendly Transparency-Enabling Technologies forPublic Administrations;1/02/2015;31/01/2018;http://routetopa.eu/;"ROUTE-TO-PA is a multidisciplinary innovation project, that, by combining expertise and research in the fields of e-government, computer science, learning science and economy, is aiming at improving the impact, towards citizens and within society, of ICT-based technology platforms for transparency.
ROUTE-TO-PA envisions that Information and Communication Technologies for Transparency must improve the engagement of citizens by making them able to socially interact over open data, by forming or joining existing online communities that share common interest and discuss common issues of relevance to local policy, service delivery, and regulation; moreover, ROUTE-TO-PA aims at engaging citizens to a higher degree by providing a robust and more holistic understanding of transparency, by underpinning the next generation open-data based transparency initiatives, ensuring that published data are those of value to citizens, with a personalized view in different forms to different segments of the citizens and public based on their profiles for facilitate better understanding.
ROUTE-TO-PA will deliver the experimented innovative and engaging ICT platforms to ensure citizen-friendly, conscious, and effective access to open-data, by offering easy understanding of, and social collaboration on, open data offered by PAs.
The objectives of Route-To-PA are: (1) develop a Social Platform for Open Data (SPOD) enabling social interactions among open data users and between open data users and government data ; (2) build Transparency-Enhancing Toolset (TET) as extensions for existing major Open Data Platforms; and (3) develop a set of recommendations (GUIDE) as good practice guide for open data publishers for achieving higher quality transparency through open data. The objectives are deployed, tested and experimented in a real setting, with at least 5 pilot studies in five different European countries.";3359875;3054625;H2020-INSO-2014;IA;UNIVERSITA DEGLI STUDI DI SALERNO;IT;"DUBLIN CITY COUNCIL;SZKOLA GLOWNA HANDLOWA W WARSZAWIE;OPEN KNOWLEDGE FOUNDATION LBG;ANDRIESSEN JEFFREY ELBERTUS BARTHOLOMEUS;COMUNE DI PRATO;ORTELIO LTD;ANCITEL SPA;NATIONAL UNIVERSITY OF IRELAND, GALWAY;UNIVERSITEIT UTRECHT;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;GEMEENTE DEN HAAG";"IE;PL;UK;NL;IT;FR"; 194490;647208;imbh;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Do intermediate-mass black holes exist?;1/09/2015;31/08/2020;;"With this proposed project I will determine whether intermediate-mass black holes (IMBHs) exist. I propose to use ESA's new Gaia mission, the rich Hubble Space Telescope data archive, and state-of-the-art techniques to investigate systems predicted to exist but not yet found hitherto, such as recoiled hyper-compact stellar systems, red-supergiant mass donors to ultra-luminous X-ray sources, and white dwarf tidal disruption events. The latter can only be detected if black holes with masses less than 1E5 Msun are involved. Using these systems and events we can probe the sphere of influence of the IMBH and determine the black hole mass dynamically.
Currently, there are strong indications for the existence of IMBHs, but dynamical evidence, the irrefutable proof of their existence, is still lacking. Whereas the unequivocal detection of an IMBH will be a breakthrough discovery in itself, it has also important consequences for searches of dark matter annihilation signals, it will provide a baseline for the rate predictions of gravitational wave radiation events involving IMBHs, and the properties of a population of IMBHs provides important constraints on the growth of supermassive black holes and galaxies. Finally, if we discover IMBHs in hyper-compact star clusters it validates numerical relativity simulations that predict that merging black holes receive a recoil kick.
My membership of Gaia's Data Processing and Analysis Consortium gives me a distinct advantage in analysing and interpreting Gaia data that, through the superb angular resolution, immediate spectroscopic observations and all-sky coverage, provides unique capabilities ideally suited for answering the question whether IMBHs exist.
My proposed project is the first to recognize the potential of Gaia (WP1&2) as well as the implications of having red supergiant mass donors in some ultra-luminous X-ray sources (WP3) for answering the question on the existence of IMBHs.";1999975;1999975;ERC-2014-CoG;ERC-COG;STICHTING SRON NETHERLANDS INSTITUTE FOR SPACE RESEARCH;NL;;; 194447;646482;FLEXICIENCY;SIGNED;H2020-EU.3.3.4.;LCE-07-2014;H2020;energy services demonstrations of demand response, FLEXibility and energy effICIENCY based on metering data;1/02/2015;31/01/2019;;Four major Distribution System Operators (in Italy, France, Spain and Sweden) with smart metering infrastructure in place, associated with electricity retailers, aggregators, software providers, research organizations and one large consumer, propose five large-scale demonstrations to show that the deployment of novel services in the electricity retail markets (ranging from advanced monitoring to local energy control, and flexibility services) can be accelerated thanks to an open European Market Place for standardized interactions among all the electricity stakeholders, opening up the energy market also to new players at EU level. The proposed virtual environment will empower real customers with higher quality and quantity of information on their energy consumptions (and generation in case of prosumers), addressing more efficient energy behaviours and usage as through advanced energy monitoring and control services. Accessibility of metering data, close to real time, made available by DSOs in a standardized and non-discriminatory way to all the players of electricity retail markets (e.g. electricity retailers, aggregators, ESCOs and end consumers), will facilitate the emergence of new markets for energy services, enhancing competitiveness and encouraging the entry of new players, benefitting the customers. Economic models of these new services will be proposed and assessed. Based on the five demonstrations, while connecting with parallel projects funded at EU or national levels on novel services provision, the dissemination activities will support the preparation of the Market Place exploitation strategies, as well as the promotion of the use cases tested during the demonstration activities.;19115935,65;13946741;H2020-LCE-2014-3;IA;E-DISTRIBUZIONE SPA;IT;"VERBUND Solutions GmbH;VATTENFALL ELDISTRIBUTION AB;FUNDACION CIRCE CENTRO DE INVESTIGACION DE RECURSOS Y CONSUMOS ENERGETICOS;JOULE ASSETS EUROPE AB OY;ENEL ENERGIA SPA;KIWI POWER LTD;ENDESA ENERGIA S.A.;SAP SE;VERBUND AG;VAASAETT LTD AB OY;AYUNTAMIENTO DE MALAGA;SIEMENS SPA;CYBERGRID GMBH;UNIVERZA V LJUBLJANI;ENDESA DISTRIBUCION ELECTRICA S.L;AGENCIA MUNICIPAL DE LA ENERGIA DE MALAGA;VATTENFALL AB;ELECTRICITE RESEAU DISTRIBUTION FRANCE SA;ENDESA SA;EUROPEAN DISTRIBUTION SYSTEMS OPERATORS FOR SMART GRIDS AISBL";"AT;SE;ES;FI;IT;UK;DE;SI;FR;BE"; 194338;645654;TOPWOOD;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Wood phenotyping tools: properties, functions and quality;1/04/2015;31/03/2019;;"The objective of TOPWOOD is to build a four-year scientific exchange program about the test and development of medium and high-throughput phenotyping measurement and analysis tools for selected basic wood properties in the laboratory and in the field (TOols for Phenotyping WOOD-TOPWOOD). The participants wish to exchange knowledge and experience for sharing and expanding skills, improving existing tools and developing new original measuring devices for wood properties involved in studies of wood quality and of wood biological functions. The phenotyping tools and methods of analysis developed and improved in TOPWOOD are intended to be used by the participants to investigate the genetic and environmental determinism of key wood properties involved in forest tree adaptation, as well as in wood production and wood quality for the forest and wood industries. The participants of TOPWOOD are three academic institutions and one private company from three European Union countries, Austria, France and Spain, and one third country, Argentina.
TOPWOOD WP1 is dedicated to the measurement of basic wood properties involved in wood quality (using near infrared spectroscopy, microdensity and ultrasonic approach). WP2 aims at studying and developing measuring devices for wood functional traits (wood hydraulic conductivity, vulnerability to cavitation and the dynamics of wood formation). WP3 aims at developing, discussing and disseminating data analysis methods dedicated to the large and complex data sets generated by these measuring devices. Finally WP4 is dedicated to coordination, management and dissemination.";675000;675000;H2020-MSCA-RISE-2014;MSCA-RISE;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE;FR;"UNIVERSITAET FUER BODENKULTUR WIEN;MADERA PLUS CALIDAD FORESTAL SL";"AT;ES"; 194290;645197;HOLA CLOUD;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Effective collaboration for European RD and Innovation in software, services and Cloud computing: Knowledge discovery and Roadmapping;1/01/2015;31/12/2016;;"HOLA CLOUD targets to establish effective mechanisms for efficient collaboration among the members of the software, services and Cloud computing community building on a decade of experiences acquired by people who are themselves core members of this community, and extends this collaboration to stakeholders who can turn the community knowledge into sustainable economic growth. Through a completely new take on scientific collaborations, researchers in the field will be given the opportunity not only to present their results, but they will be pushed to look into the future. The resulting scientific roadmap will be alloyed by database tools at the forefront of technology with federated results from past and present projects and social media into extended, searchable knowledge synthesising what Europe knows, and who knows it. This will enable companies, governments, and politicians to discover best practice solutions to their problems, and to identify future challenges that must be addressed to move European software intensive industries forward.

HOLA CLOUD will initiate an advanced conference series producing and revising an annual technology roadmap and providing an efficient venue for the members of the community to meet and exchange results and ideas for the future. To lower the barriers for industrial take-up, in particular with SMEs, HOLA CLOUD will organise an SME Event for companies to understand better how to create solutions to their problems together with the best European experts in the field. These events will be overarched by an advanced on-line knowledge platform ensuring the persistent access to information for all stakeholders. All the HOLA CLOUD activities and results will be promoted and supported by an efficient communication strategy involving an audience way beyond the normal constituency of the software, services and cloud computing domain with the aim to establish a European Cloud based eco-system that will endure after the end of the project.";818744,25;793463;H2020-ICT-2014-1;CSA;Research, Technology Development and Innovation, S.L.;ES;"UNIVERSITAET ULM;LINKNOVATE SCIENCE SL;UNIVERSITETET I OSLO;VERENIGING EUROCRIS;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS;PROMOTER SRL";"DE;ES;NO;NL;EL;IT"; 194364;645696;REMINE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Reuse of mining waste into innovative geopolymeric-based structural panels, precast, ready mixes and insitu applications;1/01/2015;31/12/2018;;The construction sector, currently in crises in some countries due to the economic development model adopted during last decades, can again play an important role for the European economy to be more innovative by using fewer resources (raw materials and energy) and reducing environmental impact (emission of greenhouse gases and dust pollution). Access to raw materials and resource efficiency are at the forefront of the EU political debate and recycling is a main part of the solution of many strategic objectives. It addresses resource scarcity and enhances security of material supply, while contributing to higher energy efficiency and lower environmental impacts. Moreover, recycling offers significant investment, innovation and employment opportunities in the EU. In this context, this RISE programme aims to promote international and inter-sector collaboration through research and innovation staff exchanges, share knowledge and ideas from research to market (and vice-versa) for the advancement of science and the development of innovation within the recycling and valorization of mining and quarrying wastes which represent 27% of the EU total waste generated from economic activities and households, promote utilization of innovative geopolymeric materials in the construction sector, and foster a shared culture of research and innovation that welcomes and rewards creativity and entrepreneurship and helps turn creative ideas into innovative products, services or processes in the materials industry through recycling mining wastes, by taking advantage of the integrated knowledge acquired in the complementary areas of the RISE partners. In this scenario, this RISE action aims at taking advantage of the recent developments in the areas of materials science, processing engineering, structural engineering, infrastructure systems, arts and design and market perspectives, turning mining waste into valuable materials for infrastructure and building products.;567000;567000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSIDADE DA BEIRA INTERIOR;PT;"BEIRA SERRA - ASSOCIACAO PROMOTORADO DESENVOLVIMENTO RURAL INTEGRADO;Refractarios ALFRAN, S.A.;SOFALCA SOCIEDADE CENTRAL DE PRODUTOS DE CORTICA LIMITADA;POLITECHNIKA SLASKA;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;ALSITEK LIMITED;BRUNEL UNIVERSITY LONDON;UNIVERSIDAD DE GRANADA;UNIVERSITY OF STRATHCLYDE";"PT;ES;PL;IT;UK"; 194613;649730;CITYnvest;SIGNED;H2020-EU.3.3.7.;EE-21-2014;H2020;Increasing Capacities in Cities for Innovative Financing in Energy Efficiency;1/02/2015;31/01/2018;;"CITYnvest strives to introduce innovative financing models (revolving funds, EPC,TPF, cooperative models, etc.) in 3 Pilot Regions (partners Lige (BE), Rhodope (BG) and Murcia (ES)) and conduct a wide-scale capacity building programme in 10 focus countries concerning specific financial instruments/business models. The assessment of innovative financial models is integral to discovering opportunities and identifying and overcoming barriers that specifically local and regional levels face. The project aims to develop a web-based portal that provides diverse practical guidance and match-makes experienced forerunners with less-experienced first-timer authorities. CITYnvest will spread the under-utilized financing models that enable project bundling and aggregation by mobilising the entire value chain at the regional/local level towards Horizon 2020s energy efficiency goals.

To succeed, the project will first tackle public authorities lack of understanding and knowledge on innovative financing models for sustainable energy services, especially retrofitting the building stock. Second, CITYnvests concrete guidance will ensure in-depth capacity building and training. Third, close collaboration with authorities will trigger innovative financing schemes implementation and mobilise finance for energy efficiency services. Organization of consistent follow-up will monitor progress towards the objective of 37,5 GWh savings/year and other commitments. Finally, the national structures (of CEMR and CA) and invited experts will liaise with the participating public authorities in the capacity building programs to achieve CITYnvests goal of ensuring long-term engagement.

CITYnvest partners liaise with an Advisory Expert Group and pool of experts to provide the expertise and guidance/training. CITYnvest will further create synergies with other wide-spread initiatives, such as the Covenant of Mayors, linking SEAPS to innovative financing models for energy efficiency.";1512938,75;1512937;H2020-EE-2014-3-MarketUptake;CSA;CLIMATE ALLIANCE - KLIMA-BUENDNIS - ALIANZA DEL CLIMA e.V.;DE;"INSTITUTO DE FOMENTO DE LA REGION DE MURCIA;GROUPEMENT DE REDEPLOIEMENT ECONOMIQUE DU PAYS DE LIEGE;RESCOOP EU ASBL;SOFIA ENERGY CENTRE LTD;CONSEIL DES COMMUNES ET REGIONS D'EUROPE-ASSOCIATION;ENERGINVEST";"ES;BE;BG"; 194335;645599;SoMa;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Soft-bodied intelligence for Manipulation;1/05/2015;30/04/2019;http://soma-project.eu/;"The main obstacle to a wide-spread adoption of advanced manipulation systems in industry is their complexity, fragility, lack of strength, and difficulty of use. This project describes a path of disruptive innovation for the development of simple, compliant, yet strong, robust, and easy-to-program manipulation systems. The idea is: Soft Manipulation (SoMa).

SoMa explores a new avenue of robotic manipulation with the environment, as opposed to manipulation of or in the environment. In our approach, the physical constraints imposed by objects in the environment and the manipulandum itself are not regarded as obstacles, but rather as opportunities to guide functional hand pre-shaping, adaptive grasping, and affordance-guided manipulation of objects. The exploitation of these opportunities, which we refer to as environmental constraints (EC), enables robust grasping and manipulation in dynamic, open, and highly variable environments.

The key ingredient for the exploitation of EC is softness of hands, i.e. their embodied ability to comply and adapt to features of the environment. The traditional paradigm for robotic manipulation is in complete disarray in front of this shift of focus: state-of-the-art grasp planners are targeted towards rigid hands and objects, and attempt to find algorithmic solutions to inherently complex, often ill-posed problems. Further complicating matters, the requirement of planning for soft, uncertain interactions between hand and environment is entirely beyond the state of the art. However, this is how humans most often use their hands, and how we plan to change robotic manipulation.";7131091,25;6321278,75;H2020-ICT-2014-1;RIA;TECHNISCHE UNIVERSITAET BERLIN;DE;"Institute of Science and Technology Austria;DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;THE WALT DISNEY COMPANY (SWITZERLAND) GMBH;UNIVERSITA DI PISA;OCADO INNOVATION LIMITED;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA";"AT;DE;CH;IT;UK"; 194573;649351;IIT;SIGNED;H2020-EU.3.6.;EURO-2-2014;H2020;Industrial Innovation in Transition;1/02/2015;31/07/2017;;"Industrial innovation has changed fundamentally over the last ten years. Companies have widely adopted new tools such as open innovation, innovation networks and ecosystems, systemic innovations, public/private partnerships, crowd sourcing, social media, and demand based innovations. These new practices have improved the innovation capabilities of companies and brought new challenges to the traditional innovation policy instruments. This project will examine widely companies current use of new innovation practices around Europe and the best practice experience of their use. It will also evaluate existing innovation policy portfolios at national and European levels, and analyze the differences between innovation processes and management practices in different industrial sectors.

The best practices and other results will be disseminated widely both to the European business community and governments to improve Europes innovation potential. International organizations such as the OECD and the ERT, industrial associations and government agencies are actively participating in the study and in the wide dissemination of its results throughout Europe.

The study will cover key industrial sectors in 11 EU Member States, with a survey aiming to achieve a response from some 800 companies. Coverage includes countries classified by the EU as Innovation Leaders, Followers and Moderate Innovators. The project will produce a toolbox for use comparative studies in other countries and use the data base created by the study to benchmark their innovation capacity against the best European practice. Some countries have already indicated their interest to conduct comparative national studies.

International research has widely shown the crucial contribution of high innovation performance to economic growth and job creation. This project will improve European industrys innovation capacity and its competitiveness and thereby help to restore economic and social development in Europe.";2377619;2377619;H2020-EURO-SOCIETY-2014;RIA;AALTO-KORKEAKOULUSAATIO;FI;"THE UNIVERSITY OF MANCHESTER;JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH;UNIVERSITEIT TWENTE;ZABALA INNOVATION CONSULTING, S.A.";"UK;AT;NL;ES"; 194269;644988;CREA;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;Network of summer academies for the improvement of entrepreneurship in innovative sectors;1/01/2015;30/04/2017;;"CREA aims to promote ICT development and creativity as new drivers able to produce specific structural changes and arrangements in the European entrepreneurial base, to influence the future paths of social change and innovation to a large extent. CREA project wants to validate a new European Model of Summer Academy for students who wants to develop business ideas focus on creativity and ICT and able to explore innovation in advanced fields: new products for new markets, social innovation, meaning drive innovation in old sectors, service innovation, technology driven innovation etc. CREA will test 2 edition of Summer Academy simultaneously organized in 6 European Cities (Milan, Stuttgart, Ljubljana, Newcastle, Tallin, Utrecht), which will end with an international event (CREA ICT Business Idea Contest) for the presentation of results to international investors and the awarding of a prize.
The project includes training courses, mentoring activities and the incubation program for start up companies that will be able to use the opportunities of ICT and Creativity to propose new business model with a European vision.
The general objectives of CREA project are:
- To create European wide system of Summer Academies for university and last year high school students entirely focused on ICT entrepreneurship;
- To create a model of Summer Academy action oriented with a strong focus on ICT and entrepreneurial skills development and a rich offer of mentoring, support for business planning, matchmaking opportunities and generation of ICT related business idea;
- To stimulate the development of new start up business ideas boosting on ICT and creativity;
- To complement and extend similar existing Summer Academy program while strongly focusing on ICT and creativity entrepreneurship;
- To organize and promote ICT Business Idea Contests.";1559422,5;1468896,37;H2020-ICT-2014-1;IA;POLITECNICO DI MILANO;IT;"SIHTASUTUS TALLINNA ETTEVOTLUSINKUBAATORID;STICHTING HOGESCHOOL VOOR DE KUNSTEN UTRECHT;UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE;UNIVERZA V LJUBLJANI;BWCON GMBH;PANEPISTIMIO AIGAIOU;ERASMUS STUDENT NETWORK ITALIA;REGIONALNA RAZVOJNA AGENCIJA - LJUBLJANSKE URBANE REGIJE ZAVOD";"EE;NL;UK;SI;DE;EL;IT"; 194475;646880;SynChI;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Striatal cholinergic cell assemblies in movement disorders;1/05/2015;30/04/2020;;"Pathological neuronal synchrony is the hallmark of many neurological disorders, including Parkinsons disease (PD) and Huntingtons disease (HD), which further share deficits in cholinergic signaling. Moreover, recent findings have underscored the therapeutic relevance of the synchrony among striatal cholinergic interneurons (ChI) that orchestrate this signaling. They have shown that excessively synchronous ChI discharge induces di-synaptic release of dopamine, GABA and glutamate. Here, I propose to elucidate how ChI synchronization is generated under normal and pathological conditions and thereby identify novel therapeutic targets to treat PD and HD. This study has only very recently become feasible with the advent of powerful tools that I have mastered to explore ChI synchrony.
We will employ a combination of cutting-edge in vitro and in vivo techniques to simultaneously record a far larger population of pre-identified ChIs than is currently possible. We will express GCaMP6, a genetically encoded calcium indicator (GECI), exclusively in ChIs, and use multiphoton microscopy to image calcium transients from several ChIs simultaneously in conjunction with intracellular recording from individual ChIs in acute brain slices and in anesthetized mice. Additionally, we will use endoscopic GECI imaging in freely-moving classically conditioned mice. We will employ modern analyses that reveal low-dimensional structures in large neuronal datasets to quantify synchrony (1) during on-going activity; (2) during optogenetic activation of afferents; and (3), in the freely-moving mice, while presenting conditioned cues. Finally, we will study the origins of pathological synchrony in PD and HD mouse models and explore means to correct this condition. This comprehensive approach should explain the pathological ChI synchrony observed in PD; identify novel targets to treat PD and HD; and create a general methodology to study pathological synchrony in many other neurological disorders.";2000000;2000000;ERC-2014-CoG;ERC-COG;THE HEBREW UNIVERSITY OF JERUSALEM;IL;;; 194311;645357;CRACKER;SIGNED;H2020-EU.2.1.1.4.;ICT-17-2014;H2020;Cracking the Language Barrier: Coordination, Evaluation and Resources for European MT Research;1/01/2015;31/12/2017;;"The European machine translation (MT) research community is experiencing increased pressure for rapid success from the legal and political frameworks and schedules of the EU, such as the Digital Single Market, but also from the globalising business world. At the same time, the research community has to cope with a striking disproportion between the scope of the challenges and the available resources, especially for translation to and from languages that have only fragmentary or no technological support at all.
CRACKER pushes towards an improvement of MT research in terms of efficiency and effectiveness by implementing the successful example of other disciplines where massively collaborative research on shared resources guided by interoperability, standardisation, agreed major challenges and comprehensive success metrics has led to breakthroughs that would have been impossible otherwise. The nucleus of this new research, development, and innovation strategy towards high-quality MT is the group of projects funded through H2020-ICT-17a/b (partly extending to relevant FP7 actions such as QTLeap, LIDER and MLi), that will be supported by CRACKER (ICT-17c) in coordination, evaluation and resources.
In order to achieve its challenging goals efficiently, CRACKER will build upon, consolidate and extend initiatives for collaborative MT research supported by earlier EU-funded actions. These include evaluation campaigns such as the Workshop on Statistical Machine Translation (WMT) and the International Workshop on Spoken Language Translation (IWSLT), the META-SHARE open infrastructure for sharing language resources and technologies with extensions for MT assembled by QTLaunchPad, and open-source tool building and training (MT Marathons). Coordination, communication and outreach to user communities will build upon existing networks and communication infrastructures such as the META-FORUM event series and strong involvement of industrial associations such as GALA and TAUS.";999995;999995;H2020-ICT-2014-1;CSA;DEUTSCHES FORSCHUNGSZENTRUM FUER KUENSTLICHE INTELLIGENZ GMBH;DE;"THE UNIVERSITY OF EDINBURGH;UNIVERZITA KARLOVA;ATHENA RESEARCH AND INNOVATION CENTER IN INFORMATION COMMUNICATION & KNOWLEDGE TECHNOLOGIES;THE UNIVERSITY OF SHEFFIELD;EVALUATIONS AND LANGUAGE RESOURCESDISTRIBUTION AGENCY;FONDAZIONE BRUNO KESSLER";"UK;CZ;EL;FR;IT"; 194321;645421;ECRYPT-CSA;SIGNED;H2020-EU.2.1.1.;ICT-32-2014;H2020;European Coordination and Support Action in Cryptology;1/03/2015;28/02/2018;;"This CSA intends to strengthen European excellence in the area of cryptology and to achieve a durable integration and structuring of the European cryptography community, involving academia, industry, government stakeholders and defence agencies. The project will coordinate ongoing research, develop a joint research agenda and foresight study, identify technology gaps and market and innovation opportunities and coordinate and strengthen standardization efforts; it will also address governance of security standards at a European level. The project will tackle through advanced training initiatives the skill shortage of academia and industry. The CSA responds to the growing attention of EU policy makers for societal needs related to privacy and cybersecurity and more in particular the trust and security component of the Digital Agenda for Europe and the European Cyber Security Strategy. The project will help to bridge the gap between academic research on the one hand and standards and industry innovations on the other hand, hereby strengthening the European industrial landscape in a strategic area. The project will result in the availability of more trustworthy security and privacy solutions `made in Europe, resulting in an increased user trust in ICT and online services and empowerment of users to take control over their data and trust relations. The work will also result in more resilient critical infrastructures and services. The project intends to reach out beyond its constituency to the broader public and to policy makers. The ECYPT-CSA consortium consists of five leading players in cryptographic research, including one SME. In order to ensure the involvement of the broader community, the project will build on a Research Advisory Board consisting of leading European researchers and a Strategic Advisory Board with leading experts from the security industry and relevant government actors.";1000000;1000000;H2020-ICT-2014-1;CSA;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;"CRYPTOEXPERTS SAS;UNIVERSITY OF BRISTOL;TECHNISCHE UNIVERSITEIT EINDHOVEN;RUHR-UNIVERSITAET BOCHUM";"FR;UK;NL;DE"; 194275;645043;HUMANE;SIGNED;H2020-EU.2.1.1.;ICT-31-2014;H2020;HUMANE: a typology, method and roadmap for HUman-MAchine NEtworks;1/04/2015;31/05/2017;;"Increasingly, activities in work and social life are conducted within human-machine networks, where collaboration involves many different actors; governments and organisations, individuals and machines such as smart devices, sensors and computing infrastructure. The targets of these networks can be for policy making, commercial innovation, education, improved quality of life, information exchange or resource organisation. As networks become more complex and include more connections between humans and machines, so the characteristics of those networks become important in determining the effectiveness and successful evolution of the collaborations which they support. Emerging challenges are: understanding the processes necessary for developing and maintaining human-machine networks such that they are able to deliver their intended outcomes; and applying this knowledge to support emerging networks in public, commercial and civil domains to more readily achieve key European goals.

In HUMANE we will develop a typology of human-machine networks focused on characteristics of relationships between networked humans and machines such as trust, motivation, reputation, responsibility, privacy and security. We will consider health indicators for networks and create prototype tools that can be exploited through a community of stakeholders to create and enrich human-machine networks. We will propose a roadmap and methodology for the evolution of such networks, appropriate to the needs of ICT developers, building on in-depth case studies taken from R&I projects relevant to the societal DAE pillars to form a supporting framework for future thinking and ICT policy-making in Europe.

The project partners in HUMANE have wide and complementary experience in social sciences and ICT R&I, essential for bridging the technological, societal, industrial and human-centric components necessary to achieve improved understanding of emerging hyper-connected human-machine networks.";1383021,25;1383021;H2020-ICT-2014-1;RIA;STIFTELSEN SINTEF;NO;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UNIVERSITY OF SOUTHAMPTON;ATHENS TECHNOLOGY CENTER SA";"UK;EL"; 194211;644460;ProCAMS;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Promoting Creativeness in Augmented Media Services;1/03/2015;30/11/2016;;"The demand for new media content where videos are augmented with computer generated graphics grows rapidly driven by the enormous amount of online videos and the advent of new eye-wear and mobile devices. In a typical video content production workflow, expensive human resources are allocated for the creation of high quality and realism videos. The high cost of content production remains mostly with SMEs representing 85% of the creative industry sector. The use of automatic video analysis can significantly optimize the existing production workflows and cut the cost. Yet the video analytics market dominated by SMEs is highly fragmented too: Video analytics is only available at high prices and locked to vendors. This limits the interoperability and results into overall market inefficiency.
This proposal offers the solution to this problem by bringing the developers of video analytics and their users from the content creating industry together on a shared video analytics WEB repository with innovative services for selecting, testing and soliciting all kinds of video analytics solutions. The repository allows the users to choose the solution with the utmost transparency: The user can directly test all available solutions in the repository with own videos. If the content creator cannot find a suitable video analytics from the wide range available, he can solicit a newly developed video analytics solution, which is tailor-made to his requirements.
The objectives of this proposal are i) establish the WEB repository; ii) define core video analytics applications relevant for content creators; iii) collect a large number of relevant video analytics applications in the WEB repository; iv) customise WEB repository services to the needs of content creators; v) demonstrate added value of the repository in eight use cases implemented by the project creative SMEs; vi) develop business model for the repository commercial operation beyond the project duration.";1311540,25;996847;H2020-ICT-2014-1;IA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"PUCK AG;ARWORKS KORLATOLT FELELOSSEGU TARSASAG;AL.MA MEDIA SOCIETA' A RESPONSABILITA' LIMITATA;LYNCEUS VISUAL TECHNOLOGIES UG HAFTUNGSBESHRANKT;MOG TECHNOLOGIES SA;LT MULTIMEDIA SOCIETA' A RESPONSABILITA' LIMITATA;BIG BAD WOLF;CODEMILL AB";"DE;HU;IT;PT;BE;SE"; 194285;645124;UMOBILE;SIGNED;H2020-EU.2.1.1.3.;ICT-05-2014;H2020;Universal, mobile-centric and opportunistic communications architecture;1/02/2015;31/01/2018;;Cars, sensors, home appliances, every device in the daily life of citizens is becoming a constituent in Future Internet, adding to the need to reconsider requirements and assumptions in terms of network availability and affordability to support the ever increasing traffic demand. Still, the current Internet can only evolve adequately, if its infrastructure can be devised to accommodate the emerging services. The increased cost of adding new infrastructure and capacity has a drastic effect on rural and remote communities as well as nomadic users as they become marginalized by not gaining access to crucial Internet services. Our goal is to make the Future Internet universally pervasive supporting a diverse set of services. To achieve this, we develop a universal mobile-centric and opportunistic communications architecture, which integrates the principles of Delay Tolerant Networking (DTN) and Information Centric Networking (ICN) in a common framework. We utilize the benefits of both ICN and DTN to enable resource exploitation at minimal bandwidth, opportunistic access to information and more localized access to information through novel caching strategies. UMOBILE focuses on assisting users in getting access to the content they want or content that may be of shared interest to their trust circles. By relying on an instance of the UMOBILE architecture, users are able to share information directly with other peers without relying on infrastructure or expensive connectivity services. The proposed architecture targets the mobile part of the networks, extends Internet connectivity to regions that are not typically covered enhancing network resilience and is fully backward compatible with the current Internet architecture. We will validate our architecture in a real world trial as well as participate strategically in carefully planned dissemination, standardization and exploitation activities to ensure that our architecture transcends from the lab to real world deployments.;3013043,75;3010742;H2020-ICT-2014-1;RIA;ATHENA RESEARCH AND INNOVATION CENTER IN INFORMATION COMMUNICATION & KNOWLEDGE TECHNOLOGIES;EL;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;COPELABS - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO EM COGNICAO E COMPUTACAO CENTRADA NAS PESSOAS;FON TECHNOLOGY SL;FUNDACION TECNALIA RESEARCH & INNOVATION;SENCEPTION LDA;DEMOCRITUS UNIVERSITY OF THRACE;UNIVERSITY COLLEGE LONDON;TEKEVER II AUTONOMOUS SYSTEMS LDA;AFA SYSTEMS SRL";"UK;PT;ES;EL;IT"; 194384;645758;TROPSENSE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Development of a non-invassive breath test for early diagnosis of tropical diseases;1/02/2015;31/01/2019;;This project aims at demonstrating the feasibility of a non-invasive, safe and patient-friendly methodology for on-site rapid diagnosis of tropical diseases. The proposed approach is based on breath samples analyses, which are easy to obtain and present no discomfort or risk for patients health. In this study will be enrolled patients with three different types of neglected tropical diseases (Hydatidosis, Leishmaniasis and Dengue) from different geographical locations (Europe, South America and Maghreb). Breath sampling will follow a standardised procedure. Analytical chemistry methods will be employed for the identification of the breath volatile biomarkers of these diseases. A pool of potential nanomaterials with high affinity towards the identified VOCs will be selected (e.g., gold nanoparticles, carbon nanotubes and semiconducting nanowires, either pristine or functionalised with selected hydrophobic organic molecules and/or bio-molecules). For maximising the possibility of success of our methodology, we will investigate the synergic effect of different advanced and complementary chemical sensing techniques: Mid-Infrared Quantum Cascade Laser spectroscopy and different types of Chemical Gas Sensors devices. These techniques are particularly attractive, since they can be miniaturised and are suitable for building on-site portable systems. Advanced pattern recognition algorithms will be employed for building discriminative models for the identification of the fingerprints of the different tropical diseases studied, and multisensors data fusion will be then applied for obtaining enhanced resulyts. A point of care prototype will be proposed on the basis of the results obtained and validated on-site.;1386000;1386000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITAT ROVIRA I VIRGILI;ES;"JLM INNOVATION GMBH;UNIWERSYTECKIE CENTRUM MEDYCYNY MORSKIEJ I TROPIKALNEJ;POLITECHNIKA GDANSKA;Institutul National de Cercetare - Dezvoltare Pentru metale Neferoase si Rare - IMNR;UNIVERSITAET ULM;TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY;SITEX 45 SRL;MOLECULAR FINGERPRINT SWEDEN AB";"DE;PL;RO;IL;SE"; 194322;645425;SSIX;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;Social Sentiment analysis financial IndeXes;1/03/2015;28/02/2018;;"Social Sentiment Indices powered by X-Scores (SSIX) aims to provide European SMEs with a collection of easy to interpret tools to analyse and understand social media users attitudes for any given subject; these sentiment characteristics can be exploited to help SMEs to operate more efficiently resulting in increased revenues. Social media data represents a collective barometer of thoughts and ideas touching every facet of society. SSIX will search and index conversations taking place on social network services, such as Twitter, StockTwits, and Facebook including the most reliable and authoritative Newswires, online newspapers, trade publications and blogs. SSIX will classify and score content using a framework of qualitative and quantitative parameters called X-Scores, regardless of language, locale or data architecture. The X-Scores framework will interpret economically significant sentiment signals in social media conversations producing sentiment metrics, such as momentum, awareness scope, topic density and historical comparison. These metrics will create commercially viable social sentiment indices, which can be tailored to any domain of interest. By enabling European SMEs to analyse and leverage social sentiment in their discipline, SSIX will facilitate the creation of innovative products and services by enhancing the investment decision making process, thus increasing revenue while also minimising risk.";4259125,5;3315963;H2020-ICT-2014-1;IA;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;"LIONBRIDGE OY;EURACTIV.COM PLC;3RDPLACE SRL;PERACTON LIMITED;REDLINK GMBH;HANDELSBLATT GMBH;UNIVERSITAT PASSAU";"FI;UK;IT;IE;AT;DE"; 194431;646325;PROSAFE;SIGNED;H2020-EU.2.1.2.2.;NMP-27-2014;H2020;Promoting the Implementation of Safe by Design;1/02/2015;30/04/2017;;"The CSA links different initiatives and facilitates the integration of results from these initiatives, so that a maximum use of these results can benefit the regulatory process. The CSA is designed to facilitate this process and show European leadership on chemical safety, including nanos.

The aim of this activity is to coordinate and support for risk assessment, management and governance by streamlining data acquisition, collection and management on regulatory orientated toxicology testing of nanomaterials, exposure monitoring, LCA, and disposal and treatment of waste nanomaterials. A number of topics were not included in NANoREG, as they fell outside the scope of that call. The principles enshrined in NANoREG will through PROSAFE be transferred to as many other member states and non-EU states as possible.

Nano-safety can be considered to improve significantly when Safe by Design is internationally accepted to guarantee safety. But it lacks agreed definitions, guarantees, and therefore confidence for acceptance. PROSAFE will facilitate and promote the acceptance of Safe by Design within the EU-COM, its Member and Associated states. Consideration is given to regulatory developments including challenges raised by the convergence between nano and biotechnologies.

To prepare for the future, after decades of playing EHS catch-up on innovations that became major environmental hazards like lead, asbestos, PCBs, a shift is needed towards a proactive approach of demonstrating safety and sustainability in pre-commercial innovation.
Priorities are:
Move from generalized discussions to case specific differences
Improve characterization of nanomaterials and require reporting on their use
Increase funding for research on ecotoxicology and environmental fate and behaviour
Use value chains assessments when considering environmental impacts
Commit to environmentally sustainable and socially robust innovation.";3095073,47;2512612;H2020-NMP-CSA-2014;CSA;MINISTERIE VAN INFRASTRUCTUUR EN MILIEU;NL;"Federal Environment Agency;INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU;INTERNATIONAL LIFE SCIENCES INSTITUTE EUROPEAN BRANCH AISBL;NANOTECHNOLOGY INDUSTRIES ASSOCIATION;INSTITUTE OF OCCUPATIONAL MEDICINE;VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;TEMAS AG TECHNOLOGY AND MANAGEMENT;ECAMRICERT SRL;RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU;ISTITUTO SUPERIORE DI SANITA;FUNDACAO PARA A CIENCIA E A TECNOLOGIA;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"DE;RO;BE;UK;IT;FR;CH;NL;PT"; 194349;645655;OCN4OS;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Organo-Catalytic Nanoparticles for Organic Synthesis;1/06/2015;31/05/2017;;The objective of this proposal is the development of a platform of recyclable organocatalysts that could be employed in the preparation of drugs or intermediates thereof. In order to achieve this objective the proposal brings together 3 partners with complementary skills: an expert in Phase Transfer Catalysis, Organo-Catalysis and synthesis (RCSI), an expert in development of DNA based catalysis and DNA elaboration (University of Nottingham) and an expert in the manufacture of polymer bound biomolecules and drug intermediates (Prigen). The relevance of the platform will be demonstrated by the their application to the preparation of unnatural aminoacids, intermediates of synthesis for active pharmaceutical ingredient Pregabalin, a new estrogen-b-receptor modulator and anti-HIV Efavirenz.;351000;351000;H2020-MSCA-RISE-2014;MSCA-RISE;ROYAL COLLEGE OF SURGEONS IN IRELAND;IE;"KEMOTECH SRL;THE UNIVERSITY OF NOTTINGHAM";"IT;UK"; 194323;645441;women entrepreneurs;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Transforming European Womens Entrepreneurship: The Education and Training for Success Programme;1/03/2015;28/02/2019;;"The objective of the women entrepreneurs project is to set up and strengthen international and inter-sectoral collaboration in the research field of competence development in young women entrepreneurs and to promote womens entrepreneurial potential in Europe.
The scientific goal is to get a better understanding of the fundamental entrepreneurial competences and to develop an educational programme to enhance the ratio of successful young women entrepreneurs across Europe. This requires academic and non-academic collaborations and the sharing of knowledge from different areas, e.g. the assessment of essential supporting competences for successful entrepreneurship, the design and provision of the educational programme, and evaluation. The partners will build a robust network covering all research areas and perfectly complement their associated expertise.
women entrepreneurs is divided into five work packages (including the work packages of project management and exploitation, dissemination and outreach activities) that will guarantee the establishment of a sustainable long-lasting network. The research objectives range from an analysis of the competences of women entrepreneurs across Europe to the design and provision of a programme that facilitates the entrepreneurial competences and the development of a learning transfer framework. Through participation in events (besides scientific conferences also Researchers Night or Girls Day), the project objectives will be transformed not only into the scientific network, but also further communicated to the general public. women entrepreneurs bears a potential for the commerzialisation of innovations, building upon an exploitation plan. Moreover, the non-academic partners represent characteristic lead users of the project outcomes.
We believe we can significantly contribute to the EU Entrepreneurship 2020 Action Plan, with the proposed collaborations and activities strengthening the sharing of knowledge in Europe.";679500;679500;H2020-MSCA-RISE-2014;MSCA-RISE;FRIEDRICH-SCHILLER-UNIVERSITAT JENA;DE;"CCKF Ltd;3S UNTERNEHMENSBERATUNG GMBH;TECHNOLOGIKO PANEPISTIMIO KYPROU";"IE;AT;CY"; 194558;649124;Phosphoprocessors;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Biological signal processing via multisite phosphorylation networks;1/05/2015;30/04/2020;;"Multisite phosphorylation of proteins is a powerful signal processing mechanism playing crucial roles in cell division and differentiation as well as in disease. Our goal in this application is to elucidate the molecular basis of this important mechanism. We recently demonstrated a novel phenomenon of multisite phosphorylation in cell cycle regulation. We showed that cyclin-dependent kinase (CDK)-dependent multisite phosphorylation of a crucial substrate is performed semiprocessively in the N-to-C terminal direction along the disordered protein. The process is controlled by key parameters including the distance between phosphorylation sites, the distribution of serines and threonines in sites, and the position of docking motifs. According to our model, linear patterns of phosphorylation networks along the disordered protein segments determine the net phosphorylation rate of the protein. This concept provides a new interpretation of CDK signal processing, and it can explain how the temporal order of cell cycle events is achieved. The goals of this study are: 1) We will seek proof of the model by rewiring the patterns of budding yeast Cdk1 multisite networks according to the rules we have identified, so to change the order of cell cycle events. Next, we will restore the order by alternative wiring of the same switches; 2) To apply the proposed model in the context of different kinases and complex substrate arrangements, we will study the Cdk1-dependent multisite phosphorylation of kinetochore components, to understand the phospho-regulation of kinetochore formation, microtubule attachment and error correction; 3) We will apply multisite phosphorylation to design circuits for synthetic biology. A toolbox of synthetic parts based on multisite phosphorylation would revolutionize the field since the fast time scales and wide combinatorial possibilities.";1999288,67;1999288,67;ERC-2014-CoG;ERC-COG;TARTU ULIKOOL;EE;;; 194306;645317;ChemoEnz;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Chemo-Enzymatic Manufacturing Routes to High- Value compounds;1/06/2015;31/05/2017;;"The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop a platform of green chemoenzymatic methods for the production of high value active pharmaceutical ingredients both those currently on the market, and those in development pipelines of the Pharma industry. The partners will exemplify the use of the platform through its application in the production of 4 drugs currently on the market namely Duloxetine, Atomexetine, Ramosetron and Paricalcitol.
In order to achieve this objective the proposal brings together 3 partners with complementary skills:
Kelada Pharmachem: Phase transfer catalysis/organo catalysis/scale-up of chemical processes
Cerbios Pharma: Biocatalysis and fermentation methodologies for drug production
IC-CNR: Protein crystallography and enzymatic engineering";234000;234000;H2020-MSCA-RISE-2014;MSCA-RISE;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;KELADA PHARMACHEM LIMITED;IE; 194296;645218;ICTIP;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;ICT Inducement Prizes Design for Innovation and Entrepreneurship;1/01/2015;29/02/2016;;"On the battle fields of Europe some centuries ago, Napoleon had a problem: how could he feed his troops when the countries he was invading were not able or inclined to provide food?
The French military leader believed in the power of inducement prizes to incentivise innovation. In 1810 he offered a reward of 12,000 francs to Franois Appert for his preserving food innovation that revolutionised the can food process and solved the problem of food scarcity in the battlefield.

In recent years, there has been a renewed interest in challenge prizes across the private, public and third sectors.

This consortium of Nesta, Scuola Superiore SantAnna and Burson Marsteller will use the full extent of the partnerships innovation, prize design and research expertise and European networks to conduct an in depth research with a focus on need and potential for breakthrough innovation, in order to design 8-12 inducement prizes in key ICT thematic areas to solve societal challenges affecting European communities.

We will carry out rigorous analysis of the market amenabilities by combining desk research and expert interviews to identify key ICT thematic areas of technological and societal challenges that potential inducement prizes will solve. We will then deliver a series of expert workshops to validate the research findings.
With our inducement prizes expertise, we will effectively use the research to design the inducement prizes and inform the most appropriate size of associated funds for each prize. This will include modelling of the inducement prize concepts, definition of success criteria and draft of prize competition rules, underpinned by plans for evaluations, operations and dissemination.
Alongside the research and design activities we will draw on our presence across Europe to draft an effective communication strategy to guarantee that inducement prizes will be well received by a broad community of traditional and non-traditional innovators and potential investors.";480450;480449,75;H2020-ICT-2014-1;CSA;NESTA LBG;UK;"SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;BURSON-MARSTELLER SPRL";"IT;BE"; 194598;649705;REVALUE;SIGNED;H2020-EU.3.3.7.;EE-19-2014;H2020;Recognising Energy Efficiency Value in Residential Buildings;1/03/2015;28/02/2018;;"ReValue aims to lead the development of appraisal norms and standards that REcorgnise Energy Efficiency Value in social and private residential real estate.

Financing decisions in real estate are often based on formal appraisals of value. Current norms on valuation, such as RICS', recognise Energy Effiency (EE) as a potential source of value, but do not require taking this into account in appraisals, nor provide clear guidance on how to do so. As a result, investors are not provided with the formal basis to invest in or to provide financing (eg through mortgages) for EE components.

For a standard renovation of a residential unit, up to 10k Euro in EE could be made ' bankable' if valuation norms and standards would better reflect long term EE value. At EU level, this could potentially unlock 20Bn Euro per year in financing of EE measures. Since 26% of EUs energy is consumed in homes, increasing investment on EE could significantly contribute to H2020 targets.

Specific ReValue objectives are:
1 develop and propose a set of norms and policies in the valuation of residential property that recognise EE
2 align valuation techniques with such norms
3 validate the framework in 4 pilot projects across Europe
4 Stimulate uptake of the framework through widely recognised norms and support from key industry stakeholders

ReValue's consortium is industry-lead, including RICS, one of the globally recognised standardisation bodies, and Savills, a leading valuer, and academic and professional experts in accounting, economics and EE design. Through observer roles, the project collaborates with building owners across Europe, investors and a range of entities that support exploitation and dissemination of project results.

In doing so, ReValue will contribute to reaching EE19's expected impact, by aligning valuation norms for optimal levels of investment of energy efficiency, and by increasing trust of investors and financiers in the financial viability of energy efficient measures.";1568750;1568750;H2020-EE-2014-3-MarketUptake;CSA;BAX & WILLEMS;ES;"VANHIER BV;SAVILLS (UK) LTD;LUWOGE consult GmbH;UNIVERSITEIT MAASTRICHT;ROYAL INSTITUTION OF CHARTERED SURVEYORS";"NL;UK;DE"; 194369;645706;GRAGE;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Grey and green in Europe: elderly living in urban areas;1/12/2014;30/11/2018;;"The EU has to face many challenges in achieving a more balanced regional development and sustainable economic recovery. Many of those challenges have to do with the ageing population trend, urbanization and environment under distress. More liveable and efficient communities is a target to be reached in Europe, where the silver hair trends can become a challenging opportunity, from a social, economic and cultural perspective. Despite those challenges are strongly interlinked, solutions provided in urban contexts not often pay due attention to the social process underlying urban trends and to the needs and behaviour of elderly citizens.
GRAGE intends to contribute to fill this gap, developing winning ideas to promote an active, harmonious and inclusive citizenship for elderly people living in urban contexts. The consortium gathers ground-breaking expertise from different scientific background (legal, economic, humanities, engineering), from academic and non academic institutions, belonging to several countries (from EU and Ukraine). Using a mix of methodologies, the research and innovation programme of the project will evolve around the idea of citizenship as a collector of interest, healthy environment and suitable urban solutions for an aging society. Main themes will be: green buildings, food and urban agriculture, information and language technology. Researcher will analyze their role in transforming cities in environments that support green and healthy lifestyles for elderly people. GRAGE intents to boost dialogue through Europe, both strengthening the academic and non-academic collaboration and a practical understanding of elderly living across Europe. Such a cooperation can have a series of returns for Europe, ranging from a more effective solution to strategic challenges (sustainable cities and demographic change) to new business opportunities for European firms, offering solutions and products for smart/inclusive/ageing societies at global level.";828000;828000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DEGLI STUDI DI MACERATA;IT;"STEFAN MARZELLI;STICHTING HAS KENNISTRANSFER EN BEDRIJSOPLEIDINGEN;OULUN KAUPUNKI;UNIVERSITEIT UTRECHT;FOOD NATION CIC;EUROPEAN QUALITY INSTITUTE SRL;OULUN YLIOPISTO;STICHTING WAAG SOCIETY;MILITOS SYMVOULEUTIKI A.E.;UNIVERSITY OF ULSTER";"DE;NL;FI;UK;IT;EL"; 194460;646580;AnyPLACE;SIGNED;H2020-EU.3.3.4.;LCE-07-2014;H2020;Adaptable Platform for Active Services Exchange;1/01/2015;31/12/2017;;"The AnyPLACE (Adaptable Platform for Active Services Exchange) project intends to develop a modular smart metering platform. The targeted system aims to provide a bidirectional service exchange gateway that enhances the interaction between end users, market representatives, electricity network operators and ICT providers. The proposed solution will allow performing energy remote metering (electricity, gas, heating and cooling), exploiting electricity networks in a more efficient manner and turning end users in active energy markets players through their engagement in demand response programs. Moreover, the utilization of the AnyPLACE platform to actively manage and control electricity networks will also allow mitigating operational problems related with the variability of renewable based generation.
To enable the development of an effective modular and flexible platform, an analysis to the different regulatory frameworks, energy/telecommunications standards, potential scenarios of deployment, technical requirements of the solution and technologies currently available will be performed. A modular and plug and play SW and HW platform will be developed in parallel with current and expected regulatory initiatives and standards. A cost-benefit analysis on different possible configurations will be developed, to ensure that appropriate configurations, or even retrofitted solutions, are designed for each context and their cost do not exceed 100.
A set of prototypes will be built with different combinations of modules to deal with different scenarios of application, which will be tested in a smart grid laboratory environment and in a field trial, providing a real-world assessment of their performance. Near-market prototype versions will be produced, accomplishing the project knowledge and technology transfer to industrial consortium partners as well as general industry and service providers.
The AnyPLACE project will also address public acceptance of the designed solutions";2974263,75;2534389,25;H2020-LCE-2014-3;IA;INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;PT;"TECHNISCHE UNIVERSITAET WIEN;EFACEC ENERGIA - MAQUINAS E EQUIPAMENTOS ELECTRICOS SA;POWER PLUS COMMUNICATIONS AG;BOSCH TERMOTECNOLOGIA SA;HOCHSCHULE OSTWESTFALEN-LIPPE;KREIS LIPPE DER LANDRAT;JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION";"AT;PT;DE;BE"; 194260;644905;IMMORTAL;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Integrated Modelling, Fault Management, Verification and Reliable Design Environment for Cyber-Physical Systems;1/03/2015;28/02/2018;;"In IMMORTAL, a consortium of leading European academic and industrial players aim at combining their expertise in developing an integrated, cross-layer modelling based tool framework for fault management, verification and reliable design of dependable Cyber-Physical Systems (CPS).
Recently, the world has seen emerging CPS modelling frameworks addressing various design aspects such as control, security, verification and validation. However, there have been no considerations for reliability and automated debug aspects of verification. The main aim is to fill this gap by introducing reliable design and automated system debug into CPS modelling. To reach this aim, the project will develop a cross-layer CPS model spanning device (analogue and digital), circuit, network architecture, firmware and software layers. In addition, a holistic fault model for fundamentally different error sources in CPSs (design bugs, wear-out and environmental effects) in a uniform manner will be proposed. Moreover, IMMORTAL plans to develop fault management infrastructure on top of the reliable design framework that would allow ultra-fast fault detection, isolation and recovery in the emerging many-core based CPS networked architectures that are expected to be increasingly adopted in the coming years.
As a result, the project will enable development of dependable CPSs with improved reliability and extended effective life-time, ageing and process variations. In line with the expected impacts of the Call, the project will have a significant impact in development time as well as maintenance costs of dependable cyber-physical systems.
The tool framework to be developed will be evaluated on a clearly specified real-world use-case of a satellite on-board-computer. However, since the results are more general and applicable to many application domains, including avionics, automotive and telecommunication, demonstration of the framework tools will be applied to CPS examples from other domains as well.";3996652,5;3996652,5;H2020-ICT-2014-1;RIA;TALLINNA TEHNIKAULIKOOL;EE;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;O TESTONICA LAB;TECHNISCHE UNIVERSITAET GRAZ;UNIVERSITEIT TWENTE;RECORE SYSTEMS BV;IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD";"DE;EE;AT;NL;IL"; 194254;644862;RAPID-MIX;SIGNED;H2020-EU.2.1.1.4.;ICT-22-2014;H2020;Realtime Adaptive Prototyping for Industrial Design of Multimodal Interactive eXpressive technology;1/02/2015;31/01/2018;;"RAPID-MIX brings together 3 leading research institutions with 4 dynamic creative industries SMEs and 1 leading wearable technology SME in a technology transfer consortium to bring to market innovative interface products for music, gaming, and e-Health applications.
RAPID-MIX uses an intensely user-centric development process to gauge industry pull and end-user desire for new modes of interaction that integrate physiological human sensing, gesture and body language, and smart information analysis and adaptation. Physiological biosignals (EEG, EMG) are used in multimodal hardware configurations with motion sensors and haptic actuators. Advanced machine learning software adapts to expressive human variation, allowing fluid interaction and personalized experience.
An iterative, rapid development cycle of hardware prototyping, software development, and application integration accelerates the availability of advanced interface technologies to industry partners. An equally user-centric evaluation phase assures market validation and end-user relevance and usability, feeding back to subsequent design cycles and informing ultimate market deployment.
The RAPID-MIX consortium leverages contemporary dissemination channels such as crowd funding, industry trade shows, and contributions to the DIY community to raise awareness across the professional and consumer landscapes of novel interface technologies.
Project output is encapsulated in an Open Source RAPID-API exposing application level access to software libraries, hardware designs, and middleware layers. This will enable creative partner SMEs to build a new range of products called Multimodal Interactive eXpressive systems (MIX). It also allows broader industries such as quantified self, and DIY communities, to use the API in their own products in cost effective ways. This assures the legacy of RAPID-MIX and marks its contribution to European competitiveness in rapidly evolving markets for embodied interaction technologies.";2682586,25;2330004;H2020-ICT-2014-1;IA;Universitat Pompeu Fabra;ES;"GOLDSMITHS' COLLEGE;INSTITUT DE RECHERCHE ET DE COORDINATION ACOUSTIQUE MUSIQUE - IRCAM;ROLI Ltd;AUDIOGAMING;REACTABLE SYSTEMS SL;PLUX - WIRELESS BIOSIGNALS S.A.;SOMETHIN' ELSE SOUND DIRECTIONS LIMITED;ORBE";"UK;FR;ES;PT"; 194307;645322;AIDE;SIGNED;H2020-EU.2.1.1.4.;ICT-22-2014;H2020;Adaptive Multimodal Interfaces to Assist Disabled People in Daily Activities;1/02/2015;31/01/2018;;"Around 80 million people in the EU, a sixth of its population, have a disability. Beside this, accessibility is a basic right for all persons with disabilities according to the article 9 of the United Nations Convention on the Rights of Persons with Disabilities signed by the European Commission in 2010. The purpose of accessibility is to enable persons with disabilities to live independently and to participate in all aspects of life.
The AIDE project has the ambition to develop and pre-clinical validate a novel and revolutionary modular and adaptive multimodal human-machine interface to allow that moderately and severely impaired people interact with intelligent devices to perform daily activities and to fully participate in society. It will, furthermore, focus on the development of a totally new shared-control paradigm for assistive devices that integrates information from identification of residual abilities, behaviours, emotional state and intentions of the user on one hand and analysis of the environment and context factors on the other hand. A series of applications for the AIDE system have been identified across several domains in which disabled people could greatly benefit: communication, home automation, wearable robots for assisting in activities of daily living and entertainment.
The validation of AIDE system will be deployed during 8 months to 5-10 users in the UK at Cedar Foundation. The final goal of this process will be to provide the proof of concept of the advantages of the AIDE system based on a novel modular, natural and adaptive multimodal interface and a shared control system to assist disabled people in accordance with specific user needs.";3409431,25;3409430,75;H2020-ICT-2014-1;RIA;UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE;ES;"THE CEDAR FOUNDATION;SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;B & J ADAPTACIONES SL;UNIVERSITAT POLITECNICA DE VALENCIA;EBERHARD KARLS UNIVERSITAET TUEBINGEN;UNIVERSITA CAMPUS BIO MEDICO DI ROMA;ZED WORLDWIDE S.A.";"UK;IT;DE;ES"; 194270;645000;LIFE;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;LearnIng from Failure in a collaborative Entrepreneurship network;1/01/2015;31/12/2016;;"The LIFE project is about collaborative learning from failure in entrepreneurship and collaborative actions to bring entrepreneurship forward.

Although cultural diversity is one of Europes biggest assets, this also creates severe obstacles for entrepreneurs to scale their efforts at the pan-European level. The distributed markets, language barriers and decentralized policy leads to: lack of access to talent & relevant expertise, to sufficient financing and to adequate facilities & networks.

Hinged on a yearly Failing Forward conference, the project will
- map out all the relevant stakeholders and programs in each of the partnering areas in a systematic way, making this available to all web entrepreneurs across Europe in one centralized platform,
- identify, share and discuss best practices & success stories

This yearly pan-European conference in Brussels will be complemented with local spin-off events in the partner regions, to
- generate and grow awareness that failure is an inherent part of the process of entrepreneurship and innovation;
- share and celebrate the success stories that were built on incremental learning;
- open up the existing startup support programs to web entrepreneurs from all over Europe";413125;413124,5;H2020-ICT-2014-1;CSA;STARTUPS.BE;BE;"ASOCIACION CHAMBERI VALLEY;ZAGREBACKI INKUBATOR PODUZETNISTVA;NUMA;STARTUP100;ASSOCIACION TETUAN VALLEY;WISE GUYS INVESTMENT OU;VSI OPEN COFFEE CLUB VILNIUS;ROB AALDERS URBAN MEDIA;F6S NETWORK LIMITED;BETA-I, ASSOCIACAO PARA A PROMOCAODA INOVACAO E DO EMPREENDEDORISMO;UNTERNEHMERTUM GMBH;FORES MEDIA LIMITED;OUTSIGHT S.L.U;STARTUP NORWAY";"ES;HR;FR;FI;EE;LT;NL;UK;PT;DE;NO"; 194196;644367;MY-WAY;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;Strengthening the web entrepreneurship ecosystem in Europe for young people by creating a pan-European network of actively engaged student networks and student entrepreneurship centres;1/01/2015;31/12/2016;;"MY-WAY aims at enhancing and improving the collaboration and efforts of web entrepreneurship initiatives (hubs, projects, accelerator networks, contests, etc.), web/business experts (accelerators, mentors, etc.), educational actors (business teachers and trainers) and the young adults as the final beneficiaries (through student networks, their alumni and student entrepreneurship centres, the student support centres). This coordination will create synergies and find ways to embed flexible services based on the existing best practices to be sustained by the student support centres in any European country at low cost. The social network of young adults across Europe will enable a wide spread of information, discovery of synergies and linkages between the actors and their services.
The active engagement of student support centres and connecting them with business networks within the web entrepreneurship ecosystem and its activities, e.g. the development of the support services (training, mentoring, access to funding, regulation, policy, etc.) will strengthen the ecosystem and will also increase the visibility and impact of the web entrepreneurship initiatives and services. A network of student support centres will act as multipliers and successfully represent the targeted young adults boosting web entrepreneurship in the long term. Primary, secondary as well as emerging web entrepreneurship hubs will be involved across Europe into the project activities. The project partnership contains representatives from across the support chain for web entrepreneurs with adequate expertise and network infrastructure to successfully engage the critical mass of stakeholders. The project will implement support actions boosting the entrepreneurial spirit, especially changing the mindset, confidence and readiness of young people for starting their own business. Special attention will be paid to female web entrepreneurship and social web entrepreneurship support.";772080,75;766124,5;H2020-ICT-2014-1;CSA;EUROPA MEDIA SZOLGALTATO NON PROFITKOZHASZNU KFT;HU;"MENLO MEDIA UG;H-FARM SPA;EUCLID NETWORK;ASSOCIATION DES ETATS GENERAUX DES ETUDIANTS DE L'EUROPE;H-Farm Italia SRL;NACUE UK LTD;EUROPEAN CONFEDERATION OF YOUNG ENTREPRENEURS AISBL;SABANCI UNIVERSITESI;THE LONDON ASSOCIATION OF ENTERPRISE AGENCIES;BAR ILAN UNIVERSITY";"DE;IT;UK;BE;TR;IL"; 194543;648613;QUMIN;TERMINATED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Quantum magnonics in insulators;1/06/2015;31/05/2020;;"In the QUMIN proposal we will build on recent developments in spintronics, circuit quantum electrodynamics and superconducting quantum computing in order to advance the fledgling research field of quantum magnonics. We will employ micro-scale magnonic resonators fabricated from YIG thin films and planar superconducting microwave resonators and superconducting transmon qubits. The combination of these basic elements will enable us to create hybrid magnon/photon and magnon/qubit quantum states and probe and control their joint coherence. An end goal of the project is to controllably entangle a superconducting qubit and a magnet.

The concept of circuit quantum electrodynamics, developed in superconducting quantum computing, has enabled strong light-matter coupling at microwave frequencies and has been one of the driving forces behind the advances in quantum computing. Over the same time frame there has been an intense development of microwave spintronics partly motivated by the discovery of spin-transfer torque and spin pumping. Most recently, motivated by its exceptional magnetic properties, there has been a renaissance of research in magnetic insulator YIG. Initial experiments show strong coupling between electromagnetic resonators and magnetic resonators. But this is just the start and a wide variety of increasingly sophisticated experiments are to follow.

An important aspect of our proposal is to use the non-uniform modes of micro-scale magnonic resonators, enabling experiments close to or at zero magnetic field to ensure compatibility with superconducting qubits. Furthermore we place an emphasis on the use of microwave spintronic techniques, using the spin-Hall effect in order to control and measure the magnonic resonator. As well as exploring this new quantum magnonics avenue, our proposal will further understanding into the room-temperature magnetic phenomena that make YIG an essential material for microwave electronics.";2399381,99;2399381,99;ERC-2014-CoG;ERC-COG;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;UK;;; 194583;649454;CULTURALBASE;SIGNED;H2020-EU.3.6.;REFLECTIVE-9-2014;H2020;Social Platform on Cultural Heritage and European Identities;1/05/2015;30/04/2017;;"Through a comprehensive perspective that includes the most relevant social and political connections, the project aims to address the proposed topic from a double standpoint, namely, an analytical as well as a public policy perspective. We start from the idea that since the second half of the last century culture has experienced a profound mutation, through which its position and role in the social dynamics have been transformed. Whereas it was previously confined to a purely superstructural position, it now constitutes an essential basis of todays society. In the context of cultural digitization and globalization the entire cultural ecosystem has changed, which has radically altered - and at the same time, intensified - the relationship between cultural identity, cultural heritage and cultural expression. This transformation has occurred both at the level of the professional cultural sector as well as in society as a whole. The new challenges and the new potential of culture, where these three pillars - cultural identity, cultural heritage and cultural expression - intertwine, will be considered in the work of the platform along three axes:

1. Cultural memory
2. Cultural inclusion
3. Cultural creativity

These are designed to research debates relating to heritage in the institutions and practices of cultural memory; how the focus on diversity and inclusion impacts on the practices of memory institutions, including on stakeholders and networks; what this reconfiguration contributes to new or post-national oriented narratives about identity and European values; and how heritage, cultural diversity and creativity relate in the context of huge cultural transformations such as the ones represented by digitization and cultural globalization.";1039266,24;998646;H2020-REFLECTIVE-SOCIETY-2014;CSA;UNIVERSITAT DE BARCELONA;ES;"UNIVERSITY OF GLASGOW;FUNDACIO INTERARTS PER A LA COOPERACIO CULTURAL INTERNACIONAL;UNIVERSITY OF SUSSEX;EUROPEAN UNIVERSITY INSTITUTE;UNIVERSITE PARIS I PANTHEON-SORBONNE;KOZEP-EUROPAI EGYETEM";"UK;ES;IT;FR;HU"; 194281;645099;EDFx;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;European Digital Forum Thought Leadership and Policy Network Exchange;1/01/2015;31/12/2016;;"The European Digital Forum (EDF) is a think tank led by the Lisbon Council and Nesta (secretariat). It was first proposed in the Startup Manifesto and later launched by European Commission Vice-President Kroes at the World Economic Forum in Davos in January 2014. Its founding partners are European Investment Fund, Telefonica, BBVA and Orange. They provided seed funding to get the EDF off the ground but the financial resources are insufficient to execute the ambitious work programme envisioned by the secretariat.

The objectives of the EDF Thought Leadership and Policy Network Exchange (EDFx) are:

1) To scale up existing activities of the EDF, enabling greater policy impact and geographical reach
2) To pursue independent research aimed at highlighting ways to measure and improve the framework conditions for web entrepreneurs
3) To facilitate a deeper, more sustained exchange between the web community and policymakers, thereby informing and shaping public policy

The objectives will be achieved through high-level policy summits and fringe events at established tech fora; the development of a one-of-its-kind indicator to measure the quality of the startup ecosystem and a repository of best practices, as well as a hard-hitting communication and community-building strategy, including policy support and monitoring actions.

EDFx will operate at the intersection of web entrepreneurship (i.e. founders, investors) and public policy (i.e. politicians, civil servants), exploiting synergies between the two groups and engaging them in a future-oriented exchange. This dialogue will be placed squarely in a broader policy setting - underlining the significance of web entrepreneurship to innovation performance, growth and job creation - and will be underpinned by a dynamic, world-class research and outreach programme. The fact that EDFx will build on a successful project that is already underway will allow it to hit the ground running to achieve speedy impact and results.";675098,75;675098,75;H2020-ICT-2014-1;CSA;The Lisbon Council for Economic Competitiveness and Social Renewal asbl;BE;"OPEN EVIDENCE;NESTA LBG";"ES;UK"; 194291;645198;OrganiCity;SIGNED;H2020-EU.2.1.1.3.;ICT-11-2014;H2020;OrganiCity Co-creating smart cities of the future;1/01/2015;30/06/2018;;"OrganiCity offers a new paradigm to European digital city making. Built on and extending the FIRE legacy, this project seeks to build a strong foundation for future sustainable cities through co-creation by a wide range of stakeholders. Globally, Europe is a champion of sustainable, inclusive and open societies. The digital age enables us to push this position further and to rethink the way we create cities and facilitate living by integrating many complex systems.
OrganiCity combines top-down planning and operations with flexible bottom-up initiatives where citizen involvement is key. So far, this has been difficult to achieve. Previous attempts to scale informal one-off projects or broaden single community projects have failed. By focusing on the city as a sociotechnical whole, OrganiCity brings software, hardware and associated human processes flexibly together into a new living city that is replicable, scalable, as well as socially, environmentally and economically sustainable.
Three clusters Aarhus (DK), London (UK) and Santander (ES) recognised for their digital urban initiatives, bring their various stakeholders together into a coherent effort to develop an integrated Experimentation-as-a-Service facility respecting ethical and privacy sensitivities and potentially improving the lives of millions of people.
The OrganiCity consortium will create a novel set of tools for civic co-creation, well beyond the state of the art in trans-disciplinary participatory urban interaction design. The tools will be validated in each cluster and integrated across the three cities.
In addition to citizen-centric join of testbeds, partner technologies and enhancements, two open calls with a budget of 1.8M will permit 25-35 experiments to use the new facility and co-creation tools. The aim is to grow sustainable digital solutions for future cities that are adjusted to the culture and capacities of each city unlocking amended services and novel markets.";7266582;7266582;H2020-ICT-2014-1;RIA;AARHUS UNIVERSITET;DK;"IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;ALEXANDRA INSTITUTTET A/S;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;ARHUS KOMMUNE;LULEA TEKNISKA UNIVERSITET;INSTITUT D'ARQUITECTURA AVANCADA DE CATALUNYA;UNIVERSITY OF MELBOURNE;INSTITOUTO TECHNOLOGIAS YPOLOGISTONKAI EKDOSEON DIOFANTOS;UNIVERSITAET ZU LUEBECK;UNIVERSIDAD DE CANTABRIA;TECNOLOGIAS SERVICIOS TELEMATICOS Y SISTEMAS S.A.;INTEL CORPORATION (UK) LIMITED;AYUNTAMIENTO DE SANTANDER;FUTURE CITIES CATAPULT LIMITED";"UK;DK;FR;SE;ES;AU;EL;DE"; 194528;648017;InvGroGra;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Asymptotic invariants of discrete groups, sparse graphs and locally symmetric spaces;1/07/2015;30/06/2020;;"The PI proposes to study the asymptotic behavior of various invariants of discrete groups and their actions, of sparse graphs and of locally symmetric spaces. The game is to connect the asymptotic behavior of an invariant on a sequence of finite models to an analytic invariant on a suitable limit object of the sequence and then use the connection to get new results in both the finite and infinite worlds. The recently emerging notion of invariant random subgroups, initiated by the PI, serves as a unifying language for convergence.

These invariants include the minimal number of generators, deficiency, Betti numbers over arbitrary fields, various spectral and representation theoretic invariants, graph polynomials and entropy. The limit objects arising are invariant processes on groups, profinite actions, graphings, invariant random subgroups and measured complexes. The analytic invariants include L2 Betti numbers, spectral and Plancherel measures, cost and its higher order versions, matching and chromatic measures and entropy per site.

Energy typically flows both ways between the finite and infinite world and also between the different invariants. We list five recent applications from the PI that emerged from such connections. 1) Any large volume locally symmetric semisimple space has large injectivity radius at most of its points; 2) The rank gradient of a chain equals the cost-1 of the profinite action of the chain; 3) Countable-to-one cellular automata over a sofic group preserve the Lebesque measure; 4) Ramanujan graphs have essentially large girth; 5) The matching measure is continuous for graph convergence, giving new estimates on monomer-dimer free energies.

Besides asymptotic group theory and graph theory, the tools of the proposed research come from probability theory, ergodic theory and statistical mechanics. The proposed research will lead to further applications in 3-manifold theory, geometry and ergodic theory.";1386250;1386250;ERC-2014-CoG;ERC-COG;MAGYAR TUDOMANYOS AKADEMIA RENYI ALFRED MATEMATIKAI KUTATOINTEZET;HU;;; 194352;645665;GEO-RAMP;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Geohazards: Risk Assessment, Mitigation and Prevention;1/04/2015;31/03/2019;;"This proposal aims to provide a step change in terms of our capacity to assess and predict risks due to geohazards (landslides and rock slides, earthquakes, floods). This is necessary in order to make built environments and infrastructures resilient to the increasing threat of natural hazards due to the expanding size of European cities and urban centres, increased use of infrastructure, and the effect of increased climatic variations. To achieve this we will bring together the complementary expertise of world leading academic groups in geotechnical, geoenvironmental and seismic engineering, soil and rock mechanics, seismology, hydrology, geology together with private engineering software companies.
The goals of this proposal are: i) to investigate the key physical-mechanical aspects of major geohazards (landslides, earthquakes, floods) with a multi-disciplinary approach in order to bridge the current gaps in knowledge and enable a step-change in the current capabilities of risk assessment, prevention, and mitigation; ii) to generate new approaches to predicting geohazards by creating an international, interdisciplinary and intersectoral group which will combine existing knowledge to generate new research methodologies and applications by enabling knowledge exchange among researchers with expertise in complementary research fields; iii) to train several Early Stage Researches (ESRs) during their stay at the host Institution who will form the next generation of researchers for academic and industrial applications; iv) to improve the current normative standards and codes ruling geohazard prevention; v) to provide a competitive edge to European engineering software companies modelling geohazards.";2146500;1804500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITY OF NEWCASTLE UPON TYNE;UK;"ITASCA CONSULTING LTD;UNIVERSITAET FUER BODENKULTUR WIEN;ITASCA CONSULTANTS;UNIVERSITAT POLITECNICA DE CATALUNYA;THE UNIVERSITY OF WARWICK;UNIVERSITE GRENOBLE ALPES;INSTITUT POLYTECHNIQUE DE GRENOBLE";"UK;AT;FR;ES"; 194308;645323;BISON;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;BIg Speech data analytics for cONtact centres;1/01/2015;31/12/2017;;"Contact centers (CC) are an important business for Europe: 35,000 contact centers generate 3.2 Million jobs (~1% of Europes active population). A typical CC produces a wealth of multilingual spoken data that is nowadays mined by humans (CC agents and supervisors) or by rudimentary technical means.

BISON consortium plans to bring significant innovations in three areas: (1) basic speech data mining technologies (systems quickly adaptable to new languages, domains and CC campaigns), (2) business outcome mining from speech (translated into improvement of CCs Key Performance Indicators) and (3) CC support systems integrating both speech and business outcome mining in user-friendly way.

The project will produce two prototypes: smallBison (end of the 1st year) will be a functioning system for real, though limited, deployment and user feedback collection. bigBison (end of the project) will include full range of capabilities and be fully integrated with CC hardware and software infrastructure. Generation of business outputs will be demonstrated on real data.

Business indicators and values for the market were instrumental for the definition of the project and will be crucial for project execution.

BISON consortium is composed of eight players with complementary skills. Two end users running large CC operations (EBOS, Atento) are generating user requirements and are ready to deploy the prototypes immediately in real scenarios. Phonexia (the coordinator), Brno University of Technology and Telefnica I\D are experts in speech data mining - from R&D, data processing to developing products placed on the market. Telefnica Mviles is an expert in business outcome mining and MyForce is a skilled Contact Center hardware and software integrator. CC data involve a number of legal issues, therefore, the University of Bologna (with significant experience in regulatory and legal aspects) complements the consortium.";4097952,5;3090824,5;H2020-ICT-2014-1;IA;PHONEXIA SRO;CZ;"EBOS LUXEMBOURG SA;TELEFONICA MOVILES ESPANA SA;ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA;VYSOKE UCENI TECHNICKE V BRNE;COMCZECH AS;TELEFONICA INVESTIGACION Y DESARROLLO SA;MyForce";"LU;ES;IT;CZ;BE"; 194292;645206;MECANEX;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Multimedia Content Annotations for Rapid Exploitation in Multi-Screen Environments;1/01/2015;30/06/2016;;The objective of MECANEX project is to devise innovative tools for automatic annotation and editorial support of multimedia content, extraction of personalized information and adaption of enriched multimedia content in multi-screen environments. As the prerequisites of production houses, broadcasters, advertising agencies and online publishing companies for enriched multimedia content increase rapidly, the need of such innovative tools is undeniable. Furthermore, the adaption of enriched multimedia content to multi-screen environments, which enable the automatic porting to different target platforms, such as regular web pages, mobile pages and mobile apps, as well as TV applications, is a significant asset for the global market of enriched multimedia content. The major novelty of MECANEX is the creation of SaaS (REST based) toolkit that provides the aforementioned functionalities by bringing together complementary expertise and technology of different European companies and research institutes, in order to provide a cost effective multi-screen video metadata enrichment solution for SMEs. Such tools will be adopted by production and post-production companies, as well as by content providers or relevant service oriented companies and will be adapted into the creation process. MECANEX will offer SMEs to semi automatically enrich video collections for multi-screen application, as well rapid prototype multi-screen concepts and test related interaction models that eventually will improve the chance for SMEs to develop more solid business models, marketing and advertising campaigns. Furthermore, a social and personalization tool is envisioned, which will collect consumers preferences and will provide feedback to the aforementioned tools. In a nutshell, automatic annotation, editorial, multi-screen and social and personalization tools will be integrated into a working MECANEX toolkit ready for the production of multimedia content, as well as the advertising agencies;1232100;989100;H2020-ICT-2014-1;IA;VCI ANONYMOS ETAIREIA KAINOTOMON LYSEON PLIROFORIKIS;EL;"FLYING EYE MANAGEMENTBERATUNG FUR MEDIENINVESTITIONEN GMBH;NOTERIK BV;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS;ISTITUTO LUCE-CINECITTA SRL";"DE;NL;EL;IT"; 194245;644798;CARDIS;SIGNED;H2020-EU.2.1.1.6.;ICT-26-2014;H2020;Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics;1/02/2015;31/07/2018;;"Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.

Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.

The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will:
Investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, micro-optics, micro-optical laser bench, optical package
Integrate the subsystems and build a multi-array laser interferometer system
Develop a process flow scalable to high volumes for all sub-systems and their integration steps
Investigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events
Validate the system in a clinical setting

Photonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).

The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.";3629207,51;3629206;H2020-ICT-2014-1;RIA;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;"FUNDICO BVBA;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;UNIVERSITEIT GENT;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;UNIVERSITEIT MAASTRICHT;MEDTRONIC BAKKEN RESEARCH CENTER B.V.;QUEEN MARY UNIVERSITY OF LONDON;SIOS MESSTECHNIK";"BE;FR;IE;NL;UK;DE"; 194239;644727;CogIMon;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Cognitive Interaction in Motion;1/02/2015;31/01/2019;;Compliant control in humans is exploited in a variety of sophisticated skills. These include solitary actions such as soft catching, sliding, pushing large objects as well as joint actions performed in teams such as mainpulation of large scale objects or mutual adaptation through phyiscal coupling for learning, in walking or in execution of joint tasks. We refer to this advanced ability of organizing versatile motion under varying contact and impedance as cognitive compliant interaction in motion. The CogIMon project aims at a step-change in human-robot interaction toward the systemic integration of robust, dependable interaction capabilities for teams of humans and compliant robots, in particular the compliant humanoid COMAN. We focus on interaction that requires active and adaptive regulation of motion and behavior of both the human(s) and the robot(s) and involves whole-body variable impedance actuation, adaptability, prediction, and flexibility. This goal shall be achieved through sophisticated real-world robot demonstrations of interactive compliant soft catching and throwing, interaction with COMANS under changing contact and team constellation, and in model-driven fully engineering multi-arm handling shared by Kuka LWR robots and humans working along. Key advancements towords this goal are targeted in mechatronics and whole-body motion control, in model-driven software engineering, in estimating and predicting motion for kinematic motion tracking data, in devising force and impedance primitives and architectures for respective technology combinations.;6974131,75;5688126;H2020-ICT-2014-1;RIA;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;DE;"IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;THE UNIVERSITY OF EDINBURGH;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;THE UNIVERSITY OF BIRMINGHAM;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;UNIVERSITAET BIELEFELD;FONDAZIONE SANTA LUCIA;EBERHARD KARLS UNIVERSITAET TUEBINGEN";"UK;CH;IT;DE"; 194417;646141;SeeingNano;SIGNED;H2020-EU.2.1.2.3.;NMP-31-2014;H2020;Developing and Enabling Nanotechnology Awareness-Building through the Creation and Exchange of enhanced Communication and Visualisation Tools and Guidance for Seeing at the Nanoscale;1/12/2014;30/11/2016;;"The SeeingNano project will create Novel Visualisation Tools for Enhanced Nanotechnology Awareness through a coordinated collaborative approach conducted by leading experts in the relevant fields: the target audiences identified in the proposal will be analysed by the consortium's socio-economic sciences and humanities, who - in collaboration with the consortium's state-of-the-art information visualisation partners - will elaborate and agree on the most appropriate tool to address the respective audiences. The scientific and technical content to be communicate through each tool to the respective audiences will be provided by experts from the nano-phenomena research community in collaboration with experts from the risk-communication and nanotoxicology community, in order to provide the key audiences with an ability to seeing at the nanoscale, and an understanding and awareness for the breadth of nanotechnologies, and the uncertainties and potential risks connected to them. The resulting tools are flexibly designed for customisation by the nanotechnology stakeholder community, and supported by guidance documents on (a) the socio-economic aspects of awareness-building exercises on nanotechnologies, (b) the science- and technology content and story boards on the nanotechnology-phenomena and their potential risks, and (c) the technical customisation of the tools provided.
It is the ultimate goal of the SeeingNano project to make available a public online SeeingNano exchange with visualisation tools, guidance and content for the enhancement of nanotechnology awareness-building exercises conducted by the nanotechnology stakeholder community. The backbone of this repository is formed by the SeeingNano output: a set of good-communication practices, developed and stress-tested within the project, supported by captivating customisable visualisation tools, to demonstrate the raising of awareness and understanding.";996478,75;996478,75;H2020-NMP-CSA-2014;CSA;NANOTECHNOLOGY INDUSTRIES ASSOCIATION;BE;"PlayGen Ltd;VAN DEN BERGH JOHANNA JACOBA;TOMATO LIMITED;UNIVERSITY OF LEEDS;BUNDESINSTITUT FUER RISIKOBEWERTUNG;ASSOCIATION EUROPEENNE DES EXPOSITIONS SCIENTIFIQUES TECHNIQUES ET INDUSTRIELLES;ZENTRUM FUR SOZIALE INNOVATION GMBH;SCHUURBIERS DANIEL";"UK;NL;DE;BE;AT"; 194181;644272;FLEXOLIGHTING;SIGNED;H2020-EU.2.1.1.6.;ICT-29-2014;H2020;FLEXOLIGHTING;1/01/2015;31/12/2017;;"The flexolighting programme is focussed on research and innovations on materials, processes and device technology for OLED lighting with the intention of building a supply chain within Europe. The aim is to realise OLED devices over a large area/surface with high brightness, high uniformity and long life time. A demonstrator will be built and delivered at the end of the project. The main targets are (i). Cost of the lighting panels should be less than Euro 1 per 100 lumens. (II). high luminous efficiency, in excess of 100 lm/W with improved out-coupling efficiency. (ii). white light life-time of at least 1000 hours at 97% of the original luminance of 5000 cdm-2. (iii). The materials and the devices therefrom will allow for differential aging of the colours, thus maintaining the same colour co-ordinates and CRI over its use. (iv). Attention will be paid to recyclability and environmental impact of the materials and the OLED lighting systems. Flexolighting project will also ensure European industrial leadership in lighting.

The introduction of OLED Lighting technology is held back by the current cost of the systems, life-time and poor uniformity of luminance on large area panels. The programme aims to combine existing state of the art OLED materials technology (Thermally activated fluorescent materials (TADF) and phosphorescent emitters and world class transport materials) with new developments in processing technologies (Organic Vapour Phase Deposition (OVPD) and printing technologies) to develop new next of generation low cost OLED lighting systems to move forward to scale up and full scale production on novel planarized flexible steel substrates with cost effective conformal encapsulation method. The transparent top contacts made of thin metallic films, conducting polymers or graphene monolayer with metal tracks to reduce the series resistance will be employed in inverted top emitting OLED structures to deliver 100 lumens per Euro.";4358983,5;4358983,5;H2020-ICT-2014-1;RIA;BRUNEL UNIVERSITY LONDON;UK;"TATA STEEL NEDERLAND TECHNOLOGY BV;AIXTRON SE;OLED TECHNOLOGIES & SOLUTIONS BV;ROBINSON BROTHERS LIMITED;INTRINSIQ MATERIALS LIMITED;NOVALIA LIMITED;MARKS AND SPENCER PLC;BENEQ OY";"NL;DE;UK;FI"; 194568;649281;EUENGAGE;SIGNED;H2020-EU.3.6.;EURO-4-2014;H2020;Bridging the gap between public opinion and European leadership: Engaging a dialogue on the future path of Europe.;1/03/2015;28/02/2018;;"The goal of the EUENGAGE Project is twofold: first, to inquire into the current tensions between supranational EU governance and popular mobilisation at the national level, critically questioning EU-driven policies and EU legitimacy; and second, to propose remedial actions based on sound empirical research on the relationship between public opinion, national and supranational political elites. The medium to long-term evolutionary trend of the EU system of supranational governance has already in the past given rise to a manifestation of problems. It has become clear that the pace of integration proposed from the top, and some side-effects of integrationausterity, transnational redistribution, economic insecurity, immigrationare difficult to accept for large parts of Europes citizens. This misalignment is obviously a crucial issue for any system of governance that aims - as the European Union has repeatedly affirmed - to be inspired by democratic principles.
The EUENGAGE project takes seriously the present state of affairs and identifies in the conflicting messages emanating from the functioning of political representation a critical and urgent problem for the future of the EU. The EUENGAGE proposes to set up an interactive, dynamic, multilevel and replicable quasi-experimental research design. Using a variety of instruments and techniques, this design will allow us not only to study the process of representation in vivo, but also to test experimentally how innovative and efficient interactions between citizens and politicians can increase citizens awareness of the common problems of the Union, and the ability of the European leadership to respond innovatively to the discontent of public opinion.";2496633;2496633;H2020-EURO-SOCIETY-2014;RIA;UNIVERSITA' DEGLI STUDI DI SIENA;IT;"KANTAR BELGIUM;STICHTING VU;LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE;UNIVERSITAET MANNHEIM;UNITELMA SAPIENZA UNIVERSITA;FUNDATIA MRC - MEDIAN RESEARCH CENTRE";"BE;NL;UK;DE;IT;RO"; 194445;646470;SmarterEMC2;SIGNED;H2020-EU.3.3.4.;LCE-07-2014;H2020;Smarter Grid: Empowering SG Market Actors through Information and Communication Technologies;1/01/2015;31/12/2017;;Power systems undergo massive technological changes due to the ever increasing concerns for environmental and energy sustainability. The increase of RES and DG penetration is one of the main goals in Europe in order to meet the environmental targets. However these goals will require new business cases and must be based on innovative ICT tools and communication infrastructure. On parallel, following the M/490 EU Mandate, CEN, CENELEC and ETSI proposed a technical report describing the Smart Grid Reference Architecture and the Smart Grids Architecture Model (SGAM) framework. A key objective of new Research and Innovation projects should be to provide solutions and ICT tools compatible with the SGAM and the standardization activity in Europe. Such new projects should also support the standardization activity by proposing additions or changes related to their objectives. Another key issue to address is whether the existing telecommunication infrastructure is sufficient to support in mass scale the new business cases and Smart Grid services. SmarterEMC2 implements ICT tools that support Customer Side Participation and RES integration, and facilitate open access in the electricity market. These tools take into account the SGAM as well the future structure of the Distribution Network as described by the relevant EU bodies and organizations. The project supports standardization activity by proposing adaptation to data models of market-oriented standards (IEC 62325-351) and field level standards (IEC 61850). Moreover, the project is fully dedicated towards achieving a maximum of impact. To validate the proposed technologies, the project includes 3 real-world pilots and large-scale simulation in 3 laboratories. The former will demonstrate the impact of Demand Response and Virtual Power Plants services in the real world settings, while the latter will reveal the ability of the communication networks to support massive uptake of such services.;3751891,25;3072655;H2020-LCE-2014-3;IA;INTRACOM SA TELECOM SOLUTIONS;EL;"DIACHEIRISTIS ELLINIKOU DIKTYOU DIANOMIS ELEKTRIKIS ENERGEIAS AE;AALBORG UNIVERSITET;AYDEM ELEKTRIK DAGITIM ANONIM SIRKETI;University of Durham;FUJITSU LABORATORIES OF EUROPE LIMITED;INESC TEC - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, TECNOLOGIA E CIENCIA;HELLENIC TELECOMMUNICATIONS ORGANIZATION S.A. - OTE AE (ORGANISMOS TILEPIKOINONION TIS ELLADOS OTE AE);Thales Italia spa;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS;ELEKTRIK DAGITIM HIZMETLERI DERNEGI BASKANLIGINA";"EL;DK;TR;UK;PT;IT"; 194266;644962;PRISMACLOUD;SIGNED;H2020-EU.2.1.1.;ICT-32-2014;H2020;PRIvacy and Security MAintaining services in the CLOUD;1/02/2015;31/07/2018;;"With a current volume of over USD 100 billion and annual growth rates of over 10%, the world-wide market for cloud computing can be considered as the major growth area in ICT. However, big companies and public authorities are reluctant to entrust their most sensitive data to external parties for storage and processing. The reason for their hesitation is clear: There exist no satisfactory approaches to adequately protect the data during its lifetime in the cloud. PRISMACLOUD addresses these challenges and yields a portfolio of novel security enabled cloud services, guaranteeing the required security for sensitive data in the cloud.
Techniques for outsourcing computation with verifiable correctness and authenticity-preservation allow to securely delegate computations to cloud providers. A distributed multi-cloud data storage architecture shares data among several cloud providers and improves security and availability. Dynamically updating shares by means of novel techniques avoids vendor lock-in, preserves data authenticity, facilitates long term privacy and promotes a dynamic cloud provider market. Claims about the secure connection and configuration of the virtualized cloud infrastructures and properties of cloud topologies are verifiable by means of cryptographic techniques. User privacy issues are addressed by data minimization and anonymization technologies due to the application of privacy-preserving cryptographic techniques. As feasibility proof, three use cases from the fields of SmartCity, e-Government, and e-Health, will be implemented and evaluated by the project participants.
The PRISMACLOUD work program is complemented with activities addressing secure user interfaces, secure service composition, secure implementation in software and hardware, security certification, and an impact analysis from an end-user view. In order to converge with the European Cloud Computing Strategy, a strategy for the dissemination of results into standards is developed.";8381952,5;7983008,75;H2020-ICT-2014-1;RIA;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;AT;"MIKROPLAN GMBH;TECHNISCHE UNIVERSITAET GRAZ;UNIVERSITE DE LAUSANNE;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;UNIVERSITY OF NEWCASTLE UPON TYNE;LOMBARDIA INFORMATICA SPA;FONDAZIONE CENTRO SAN RAFFAELE;ETRA INVESTIGACION Y DESARROLLO SA;UNIVERSITAT PASSAU;TECHNISCHE UNIVERSITAT DARMSTADT;INTEROUTE S.P.A.;ATOS SPAIN SA;XITRUST SECURE TECHNOLOGIES GMBH;IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD;KARLSTADS UNIVERSITET";"DE;AT;CH;FR;UK;IT;ES;IL;SE"; 194255;644866;SSICLOPS;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Scalable and Secure Infrastructures for Cloud Operations;1/02/2015;31/01/2018;;"The SSICLOPS project will focus on techniques for the management of federated private cloud infrastructures, in particular cloud networking techniques (within software-defined data centres and across wide-area networks). Key deliverables from the project will include a meta data description language for workloads, resources and policies, a flexible scheduling system using meta data, workload-specific adaptations to TCP/IP stacks, and data center performance analysis tools.
Addressing topics, such as dynamic configuration, automated provisioning and orchestration of cloud resources the SSICLOPS projects will investigate high-performance, vertically integrated network stacks for intra/inter-cloud communication and efficient, scalable, and secure intra/inter-DC and client-facing transport mechanisms.
The project will design, implement, demonstrate, and evaluate three specific use cases, namely a cloud-based in-memory database, the analysis of physics experiment data, and the prototypical extension of network stacks for a telecom provider in the SSICLOPS testbed.";6937123;6702748;H2020-ICT-2014-1;RIA;AALTO-KORKEAKOULUSAATIO;FI;"HELSINGIN YLIOPISTO;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;NEC EUROPE LTD;TECHNISCHE UNIVERSITAET MUENCHEN;ORANGE POLSKA SPOLKA AKCYJNA;F-SECURE OYJ;TELEKOM DEUTSCHLAND GMBH;UNIVERSITA DI PISA;UNIVERSITATEA POLITEHNICA DIN BUCURESTI;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;NETAPP BV;MARTEL GMBH;HASSO-PLATTNER-INSTITUT FUR SOFTWARESYSTEMTECHNIK GMBH";"FI;UK;DE;PL;IT;RO;NL;CH"; 194514;647981;3DSPIN;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;3-Dimensional Maps of the Spinning Nucleon;1/07/2015;30/06/2020;;"How does the inside of the proton look like? What generates its spin??3DSPIN will deliver essential information to answer these questions at the frontier of subnuclear physics.
At present, we have detailed maps of the distribution of quarks and gluons in the nucleon in 1D (as a function of their momentum in a single direction). We also know that quark spins account for only about 1/3 of the spin of the nucleon.
3DSPIN will lead the way into a new stage of nucleon mapping, explore the distribution of quarks in full 3D momentum space and obtain unprecedented information on orbital angular momentum.
Goals
1. extract from experimental data the 3D distribution of quarks (in momentum space), as described by Transverse-Momentum Distributions (TMDs);
2. obtain from TMDs information on quark Orbital Angular Momentum (OAM).
Methodology
3DSPIN will implement state-of-the-art fitting procedures to analyze relevant experimental data and extract quark TMDs, similarly to global fits of standard parton distribution functions. Information about quark angular momentum will be obtained through assumptions based on theoretical considerations. The next five years represent an ideal time window to accomplish our goals, thanks to the wealth of expected data from deep-inelastic scattering experiments (COMPASS, Jefferson Lab), hadronic colliders (Fermilab, BNL, LHC), and electron-positron colliders (BELLE, BABAR). The PI has a strong reputation in this field. The group will operate in partnership with the Italian National Institute of Nuclear Physics and in close interaction with leading experts and experimental collaborations worldwide.
Impact
Mapping the 3D structure of chemical compounds has revolutionized chemistry. Similarly, mapping the 3D structure of the nucleon will have a deep impact on our understanding of the fundamental constituents of matter. We will open new perspectives on the dynamics of quarks and gluons and sharpen our view of high-energy processes involving nucleons.";1509000;1509000;ERC-2014-CoG;ERC-COG;UNIVERSITA DEGLI STUDI DI PAVIA;IT;ISTITUTO NAZIONALE DI FISICA NUCLEARE;IT; 194276;645047;SANSA;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;Shared Access Terrestrial-Satellite Backhaul Network enabled by Smart Antennas;1/02/2015;31/01/2018;;"The aim of SANSA project is to boost the performance of mobile wireless backhaul networks in terms of capacity and resilience while assuring an efficient use of the spectrum. Recently, a global mobile traffic increase of 11-fold between 2013 and 2018 was predicted, so novel solutions are required to avoid backhaul becoming the bottle neck of future mobile networks. The solution envisaged in SANSA is a spectrum efficient self-reconfigurable hybrid terrestrial-satellite backhaul network based on three key principles: (i) a seamless integration of the satellite segment into terrestrial backhaul networks; (ii) a terrestrial wireless network capable of reconfiguring its topology according to traffic demands; (iii) a shared spectrum between satellite and terrestrial segments. This combination will result in a flexible solution capable of efficiently routing the mobile traffic in terms of capacity and energy efficiency, while providing resilience against link failures or congestion and easy deployment in rural areas. Therefore, we will develop novel smart antennas, dynamic radio resource management and data-based shared access techniques for enabling the spectrum sharing among both segments, as well as efficient management and routing solutions for the hybrid network. These studies will yield to the implementation and demonstration of the two key components proof of concepts: (i) low-cost smart antennas (to be deployed in terrestrial nodes) with beam and null-steering capabilities for interference mitigation between satellite and terrestrial transceivers and network topology reconfiguration; (ii) hybrid network manager capable of controlling the resources of the hybrid network. Besides indirectly allowing the traffic increase to the mobile users, the SANSA project will set the path for a win-win collaboration between satellite and terrestrial operators that will strengthen both European sectors and also their related industries such as equipment manufacturers.";3557680;2983930;H2020-ICT-2014-1;RIA;CENTRE TECNOLOGIC DE TELECOMUNICACIONS DE CATALUNYA;ES;"UNIVERSITE DU LUXEMBOURG;VIASAT ANTENNA SYSTEMS SA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;HELLENIC TELECOMMUNICATIONS ORGANIZATION S.A. - OTE AE (ORGANISMOS TILEPIKOINONION TIS ELLADOS OTE AE);AVANTI COMMUNICATIONS LTD;THALES ALENIA SPACE ESPANA, SA;RESEARCH AND EDUCATION LABORATORY IN INFORMATION TECHNOLOGIES";"LU;CH;DE;EL;UK;ES"; 194340;645535;CHEQUERS;SIGNED;H2020-EU.2.1.1.6.;ICT-26-2014;H2020;Compact High pErformance QUantum cascadE laseR Sensors;1/03/2015;31/08/2018;;In this proposal we describe a timely and disruptive solution to the long-standing and vexing problem of the rapid stand-off detection of explosive, toxic or otherwise hazardous materials which are present within potential- or post-terrorist attack or industrial accident sites. We will achieve this by realising highly sensitive, state-of-the-art handheld and tripod-mounted instruments based upon active hyperspectral imaging and detection. These will exploit the deep infrared molecular fingerprint waveband region, where these hazardous compounds exhibit their strongest and most distinctive optical absorption features. Crucially, by keeping our goal fixed on the needs of the end-user, we will realise high-TRL devices which are cost-effective, lightweight and highly utile. Within the lifetime of this project, these will ready for evaluation in end-use scenarios (as opposed to mere laboratory-based demonstration). Our consortium is uniquely placed to prosecute this programme as is it comprises world leading workers in every technology upon which this solution depends, from quantum-cascade laser source, MEMS and detector growth expertise to advanced imaging, signals processing and device integration. One refined, the technology we will pioneer will be evaluated by civil security partners who will implement them in a number of likely end-use scenarios, thus proving the potency and utility of our technology.;3333492;3325668;H2020-ICT-2014-1;RIA;Kite Innovation (Europe) Limited;UK;"BUNDESKRIMINALAMT;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;M-SQUARED LASERS LIMITED;VIGO SYSTEM S.A.;FRAUNHOFER UK RESEARCH LIMITED";"DE;UK;PL"; 194224;644625;iART;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Consumer-oriented ICT Solutions for creative SMEs providing Art in Bespoke Fashion;1/01/2015;30/06/2016;;"The main objective of the iART project is to bring visual art into bespoke clothing so as to make apparel products more valuable compared to other garments in the market and to support artists to exploit their work. To reach this objective a set of innovative ICT solutions has to be developed first.
This new approach will also change the business relationship along the conception and design phase in the clothing sector from B2B to B2C, where the artist and the consumer will connect through enabling platforms like iArt. iArt will be built upon an existing B2C webshop for bespoke shirts Bivolino.com.
In particular, the specific ICT developments of the project are:
1. Upgrade the configuration toolkit from 2.5D to 2.5D/3D by including shadowing and rotating features without the need of plug-ins and ease the extension of the catalog to clothing accessories and nightwear fitting with the shirts.
2. Move to real-time online rendering (fabric draping), so as to speed up and increase the flexibility of the whole process from artist design over fabric creation to customized bespoke shirts and other garments (fabric rendering on 2.5D/3D clothing configurator).
3. Build a B2C platform enabling co-creation and user generated art content. Develop an Advanced Artist Interface (AAI) with artist cockpit. Implement an advanced user interface to allow easy 2.5D/3D viewing in many other platforms through open API.
iART is expected to create extra revenues for Artists micro SMEs. The European Fashion and Clothing industry SMEs take up ICT enabling innovative supply-chains to generate more revenues through high-margin made-to-order collections which cannot be imported from mass production countries. Finally ICT providers are stimulated to offer innovative tools generating business and turnover.
As this sustainable business model is supported by easily accessible advanced ICT tools (through open APIs) it will be replicable and so has the potential to create a wide impact.";618129,21;491705;H2020-ICT-2014-1;IA;DOULOU NV;BE;"VANMECHELEN MIEKE;ANDRIESSEN CORNELIS CHRISTIAAN JACOB;ZDZIESZYNSKA LIDIA;UNIVERSITEIT HASSELT";"IE;NL;PL;BE"; 194293;645212;NEPHELE;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;eNd to End scalable and dynamically reconfigurable oPtical arcHitecture for application-awarE SDN cLoud datacentErs;1/02/2015;31/01/2018;;"Datacentre traffic is experiencing 2-digit growth challenging the scalability of current network architectures. The new concept of disaggregation exacerbates bandwidth and latency demands whereas emerging cloud business opportunities urge for reliable inter-datacenter networking.
PROJECT will develop an end-to-end solution extending from the datacenter architecture and optical subsystem design to the overlaying control plane and application interfaces. PROJECT hybrid electronic-optical network architecture scales linearly with the number of datacenter hosts, offers Ethernet granularity and saves up to 94% power and 30% cost. It consolidates compute and storage networks over a single, Ethernet optical TDMA network. Low latency, hardware-level dynamic re-configurability and quasi-deterministic QoS are supported in view of disaggregated datacenter deployment scenarios. A fully functional control plane overlay will be developed comprising an SDN controller along with its interfaces. The southbound interface abstracts physical layer infrastructure and allows dynamic hardware-level network reconfigurability. The northbound interface links the SDN controller with the application requirements through an Application Programming Interface. PROJECT innovative control plane enables Application Defined Networking and merges hardware and software virtualization over the hybrid optical infrastructure. It also integrates SDN modules and functions for inter-datacenter connectivity, enabling dynamic bandwidth allocation based on the needs of migrating VMs as well as on existing Service Level Agreements for transparent networking among telecom and datacenter operators domains.
Fully-functional network subsystems will be prototyped: a 400Gb/s hybrid Top-of-Rack switch, a 50Gb/s electronic-optical smart Network Interface Card and a fast optical pod switch. PROJECT concept will be demonstrated in the lab and in its operational environment for both intra- and inter-datacenter scenario";3053636,25;3053636;H2020-ICT-2014-1;RIA;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS;EL;"SEAGATE SYSTEMS UK LIMITED;GESELLSCHAFT FUR WISSENSCHAFTLICHE DATENVERARBEITUNG MBH GOTTINGEN;NEXTWORKS;MELLANOX TECHNOLOGIES LTD - MLNX;INTEROUTE S.P.A.;PANEPISTIMIO PATRON";"UK;DE;IT;IL;EL"; 194553;648991;3MC;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;3D Model Catalysts to explore new routes to sustainable fuels;1/09/2015;31/08/2020;;"Currently fuels, plastics, and drugs are predominantly manufactured from oil. A transition towards renewable resources critically depends on new catalysts, for instance to convert small molecules (such as solar or biomass derived hydrogen, carbon monoxide, water and carbon dioxide) into more complex ones (such as oxygenates, containing oxygen atoms in their structure). Catalyst development now often depends on trial and error rather than rational design, as the heterogeneity of these composite systems hampers detailed understanding of the role of each of the components.

I propose 3D model catalysts as a novel enabling tool to overcome this problem. Their well-defined nature allows unprecedented precision in the variation of structural parameters (morphology, spatial distribution) of the individual components, while at the same time they mimic real catalysts closely enough to allow testing under industrially relevant conditions. Using this approach I will address fundamental questions, such as:
* What are the mechanisms (structural, electronic, chemical) by which non-metal promoters influence the functionality of copper-based catalysts?
* Which nanoalloys can be formed, how does their composition influence the surface active sites and catalytic functionality under reaction conditions?
* Which size and interface effects occur, and how can we use them to tune the actitivity and selectivity towards desired products?

Our 3D model catalysts will be assembled from ordered mesoporous silica and carbon support materials and Cu-based promoted and bimetallic nanoparticles. The combination with high resolution characterization and testing under realistic conditions allows detailed insight into the role of the different components; critical for the rational design of novel catalysts for a future more sustainable production of chemicals and fuels from renewable resources.";1999625;1999625;ERC-2014-CoG;ERC-COG;UNIVERSITEIT UTRECHT;NL;;; 194498;647344;DIvA;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Chromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI;1/07/2015;30/06/2020;;"'Among the types of damage, DNA Double Strands Breaks (DSBs) are the most deleterious, as illustrated by the variety of human diseases associated with DSB repair defects. Repair of DSB into the chromatin context raises several questions that we aim to address in this proposal. Firstly, it is likely that the chromatin environment where a break occurs influences the choice of repair pathway. Since the different DSB repair mechanisms can lead to different 'scar' on the genome, further studies are required to elucidate how chromatin structure regulates the targeting of DSB repair machineries. Secondly, DNA packaging into chromatin hinders detection and repair of DSBs and many chromatin modifications were recently identified as induced around DSBs to facilitate repair. However, a complete picture of the chromatin landscape set up at DSB, and more specifically the set of histone modifications associated with each repair pathway ('repair histone code') is still awaited. In addition, whether and how damaged chromosomes are reorganized within the nucleus is still unknown. Finally, once repair has been completed, the initial chromatin landscape must be faithfully restored in order to maintain epigenome stability and cell fate.
Using an experimental system we recently developed (called DIvA for DSB Inducible via AsiSI), that allows the induction of multiple sequence-specific DSBs widespread across the genome, we propose to investigate these uncovered aspects of the relationship between chromatin and DSB repair. By high-throughput genomic and proteomic technologies, we will try (i) to understand the contribution of chromatin in the DSB repair pathway choice (PRIME), (ii) to describe more thoroughly the chromatin remodeling events and the spatial chromosomes reorganization, that occur concomitantly to DSB to promote adequate repair (REPAIR), and (iii) to elucidate the processes at work to restore epigenome integrity after DSB repair (RESTORE).'";2000000;2000000;ERC-2014-CoG;ERC-COG;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;;; 194430;646451;SMPFv2.0;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Next generation single molecule protein fluorescence;1/09/2015;31/08/2020;;Fluorescence techniques provide powerful means to study single protein machineries. Single molecule observation of Fluorescence Resonance Energy Transfer (FRET) has become an important tool for probing structure, distances, dynamics, physicochemical properties and size of purified (in vitro) protein complexes. Super-resolution techniques provide complementary spatial information about proteins in live (in vivo) specimen. Although these techniques have become very popular because of their high sensitivity, their throughput is limited by large statistical sampling requirements, complex sample preparation procedures and/or laborious data acquisition workflows. Here, I propose to design a unified single molecule approach by engineering ultrafast, semi-synthetic protein modification techniques and fluorescent readouts into nano/microfluidic hybrid devices. The development of an automated all-in-one Lab-on-a-Chip platform will dramatically improve throughput of single molecule fluorescence techniques. The technology will provide a multiparameter readout of molecular protein mechanisms across time, resolution and complexity scales in a generalised workflow. To demonstrate the power of the new platform, I will apply it to a mechanistic study of the multifunctionality of intrinsically disordered proteins (IDPs), which are vital to cellular function and associated with many disease mechanisms. The polymeric properties of IDPs enable them to populate a variety of states and engage with various cellular binding partners, thus exceeding the sampling limit of existing single molecule technologies. The new method will blur the boundaries between in cell superresolution microscopy and biochemical single molecule studies and unleash the true power of single molecule protein science for a range of applications in analytical sciences, drug discovery, biotechnology, systems biology and fundamental biomedical research.;1996990;1996990;ERC-2014-CoG;ERC-COG;EUROPEAN MOLECULAR BIOLOGY LABORATORY;DE;;; 194277;645067;FURNIT-SAVER;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Smart Augmented and Virtual Reality Marketplace for Furniture Customisation;1/02/2015;31/03/2016;;"The European furniture market has undergone dramatic changes in the recent past, with a relatively cottage industry populated by many small companies becoming increasingly dominated by the growth of bulk retailers. The traditional nature of the furniture industry and the limited incorporation of ICT tools, have further reduced the ability of SMEs in the sector to innovate and respond to the competition.

These small companies have been unable to compete with the economies of scale advantages that larger retailers can offer. These scale advantages come from offering a wide range of standardised products and selling them to many people. These larger companies also tend to offer relatively cheap and impermanent products that can be replaced if they do not fit the customer's needs.

A potential competitive advantages for smaller furniture companies is the ability to provide customised goods that meet the customers' demands and are of greater quality and durability. However, as it is impossible to envisage how the furniture will look and fit into the customers home, customised furniture also bears an expensive risk if the final piece of furniture does not meet the customer's needs.

Recent developments in virtual and augmented reality technologies offer furniture SMEs the opportunity to remove these risks. Allowing the customers to see the customised furniture in their home environment and to adapt it to their own particular tastes and needs by using an automatic recommender system, will give creative SMEs a competitive advantage over larger companies.

The FURNIT-SAVER project will make use of VR/AR technologies, recommendation engines and a user interface to produce a smart marketplace for furniture customisation. It will enable customers to make accurate 3D plans of the rooms they wish to design, recommend, customise and visualise different furniture, before visualising it in their home environment using Augmented Reality.";1103843,75;952437,5;H2020-ICT-2014-1;IA;FUNDACIO EURECAT;ES;"CENTRE DE DIFUSIO TECNOLOGICA DE LA FUSTA I DEL MOBLE DE CATALUNYA;GONZAGA-PRO PROIZVODNJA, TRGOVINA, INZENIRING D.O.O;ADVANCED COMPUTER SYSTEMS A.C.S. SPA;WW E-SERVICES IBERIA SL;ZAVOD LESARSKI GROZD";"ES;SI;IT"; 194251;644847;DIGISTART;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;Support Ecosystems for Digital Startups;1/01/2015;30/06/2017;;"Online Businesses are significantly different from traditional businesses due to a variety of factors such as relatively low entry costs, high word of mouth, low incremental costs, high efficiency of viral marketing strategies amongst others. Quick deployment, rapid prototyping, low cost of market tests and introduction along with the right business model and pricing strategy are some of the vital elements that can ensure success or failure. These challenges are quite daunting to cope even for seasoned entrepreneurs but much more challenging for younger entrepreneurs. While several startup initiatives, business accelerators and localised business support ecosystems have come up to provide these specialised skills and support services, the main barriers to a large scale web entrepreneurship ecosystem in Europe are:

i) A significant gap between University Students who form the largest pool of potential young entrepreneurs and the business accelerators providing support to such initiatives.
ii) Lack of internetworking between the various business accelerators, investors, mentors to coordinate their activities to reach a much wider audience across the widely dispersed European communities.
iii) Lack of Business Analytical Tools that can help digital startups optimise their business models and pricing decisions.

There is a strong need to develop an ecosystem of web entrepreneurship, where budding entrepreneurs can find the right support to let their ideas blossom into viable business models, with access to the necessary inputs such as funding, mentoring, and access to the necessary technical resources and IT skills. That is why 2 business accelerators from 2 different European regions: Portugal and Scandinavia came together to develop a coordinated set of support actions with the coordination of an academic partner (UNIDEMI) to leverage the use of the largest European Startup Web- Platform F6S for a range of activities that support web-startups.";584375;584375;H2020-ICT-2014-1;CSA;FACULDADE DE CIENCIAS E TECNOLOGIADA UNIVERSIDADE NOVA DE LISBOA;PT;"F6S NETWORK LIMITED;BETA-I, ASSOCIACAO PARA A PROMOCAODA INOVACAO E DO EMPREENDEDORISMO;CLUSTERLAND SWEDEN AB";"UK;PT;SE"; 194334;645560;AXIOM;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Apertus eXtendable Integrated Open Modular Cinema Camera;15/03/2015;14/06/2016;;"'AXIOM introduces the first professional, extendable, affordable and modular cinema camera platform based on Free Software, Open Design, Open Hardware, transparent development processes and extensive documentation. The project establishes an ecosystem that offers a sustainable basis for a broad spectrum of audiovisual applications and empowers enthusiasts, videographers as well as developers in the technology and creative industry sectors.

AXIOM is not meant to be just one fixed product but rather an open platform stimulating the collaboration of the creative industry with a viable ecosystem for innovative (value-added) products and services. The project aims to show a best-practice example in European Open Hardware development and documentation. There is no comparable product on the market yet.
AXIOM targets the demand for emerging technologies in the creative industry and imaging sectors (eg. cinema, broadcast, science or medical use): high-resolution (4K), high frame-rate (HFR), global shutter, open design (Open Hardware, FLOSS), modular system, using only open standards.

AXIOM is a project of ground-breaking nature. We are expecting the project to be a best-practice-example, with very high potential to disrupt the creative industries in the imaging and video sectors.

AXIOM is:
-) a system between industrial and high end digital cinema camera, for a fraction of the price
-) highly modular: customizable (software, hardware, FPGA)
-) using open standards exclusively

The proposed action includes prototyping, testing, demonstrating and piloting the AXIOM Open Integrated Modular Cinema Camera dubbed 'AXIOM Gamma'. AXIOM will be presented at the international M.I.T. Open Hardware Summit 2015, research data and results will be released under a free licence.'";1224375;991687,5;H2020-ICT-2014-1;IA;UNIVERSITAT FUR ANGEWANDTE KUNST WIEN;AT;"Antmicro Sp. z o. o.;Przisions-Entwicklung DENZ Fertigungs-GmbH;APERTUS - ASSOCIATION SUPPORTING OPEN AND FREE AUDIOVISUAL MEDIA AND TECHNOLOGY;AF INVENTIONS GMBH";"PL;DE;AT"; 194402;645886;YDS;SIGNED;H2020-EU.3.6.;INSO-1-2014;H2020;Your Data Stories;1/02/2015;31/01/2018;http://yourdatastories.eu/;"'The revolution in information technology over the last years has proven its ability to process huge amounts of data and made evident that big data can change the world. Open Government Data (OGD), from being an obscure possibility just five years ago, is spreading across the globe at a phenomenal rate, delivering the promise to spur innovation, to deliver better services for less money, to improve planning, to increase transparency, and to reduce corruption. In this context, YourDataStories envisions to bring this promise closer to reality, through a highly customisable online platform for data exploitation focused in the financial flows that are critical for transparency, collaboration and participation. Users, ranging from governmental bodies to journalists and to citizens, will be facilitated by powerful and established tools, not only to discover relevant information but also to remix it with diverse and dynamic data sources: YourDataStories acts like an interactive canvas to enable data citizens to (re)write their own data history.
YourDataStories brings an innovative solution whose innovation potential spreads across many directions, from leveraging best practices and proven technologies across Europe, to exploiting the social Web for accessing citizens, and to supporting sustainable public services across borders. Building on top of the 'Transparency Portal' initiative of the Greek government, YourDataStories can be viewed as a way to showcase and transfer the existing expertise to European level, in an attempt to transform governments and governance in Europe. At the same time, YourDataStories seeks to exploit and embed in this effort the benefits of the social Web, establishing an innovative bidirectional channel between the Social and Semantic Web. Finally, YourDataStories aims to support sustainable services, supported by a marketing ecosystem of applications offering cross-border services of public finance flows across Europe.'";2802188;2469038;H2020-INSO-2014;IA;ATHENS TECHNOLOGY CENTER SA;EL;"GALWAY CITY COUNCIL;ETAIREIA ELEYTHEROY LOGISMIKOY LOGISMIKOY ANOIKTOY KODIKA;Hellenic Ministry of Interior and Administrative Reconstruction;NATIONAL UNIVERSITY OF IRELAND, GALWAY;Department of Public Expenditure and Reform;""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS"""""";DEUTSCHE WELLE;TENFORCE BVBA;STICHTING EUROPEAN JOURNALISM CENTRE";"IE;EL;DE;BE;NL"; 194209;644435;SIGNAT;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Evaluation of Plant Signaling Networks in Natural Environments;1/07/2015;30/06/2019;;"A critical characteristic of plant development is the strong influence of environmental factors as modulators of developmental programs. Among those factors, light, temperature and nutrient availability dominate developmental decisions, and can dramatically alter plant shape, biomass production and fruit set all of them important agronomic traits. Research during the past thirty years has defined different molecular mechanisms by which plants perceive environmental signals and transduce this information into changes in gene expression and other cellular processes, ultimately triggering the appropriate adaptive responses. However, current knowledge has at least two important weaknesses: (i) it is based on mostly on the analysis under conditions where only one environmental factor is changed, while natural environments are more complex; and (ii) most studies have been performed at the seedling stage, while the influence of the environment becomes even more relevant at later stages from an agronomical perspective. This project addresses the evaluation plant performance under complex combinations of light, temperature and nutrient conditions, using the previous knowledge generated by the participants and other laboratories, and analyzing three key stages of a plants life: seedling establishment, vegetative growth (biomass production), and reproductive development (flowering and fruit set). The international consortium is formed by researchers from five countries, with strong complementary technical and scientific expertises spanning light and temperature signaling, hormone action, natural genetic variation, large-scale phenotyping of adult plants, nutrient assimilation and systems biology integration.";414000;414000;H2020-MSCA-RISE-2014;MSCA-RISE;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;ES;"MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;UMEA UNIVERSITET";"DE;SE"; 194538;648509;LaDIST;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Large Discrete Structures;1/12/2015;30/11/2020;;The proposed project seeks to introduce novel methods to analyze and approximate large graphs and other discrete structures and to apply the developed methods to solve specific open problems. A need for such methods comes from computer science where the sizes of input structures are often enormous. Specifically, the project will advance the recently emerged theory of combinatorial limits by developing new insights in the structure of limit objects and by proposing a robust theory bridging the sparse and dense cases. The analytic methods from the theory of combinatorial limits will be used to analyze possible asymptotic behavior of large graphs and they will be applied in conjunction with structural arguments to provide solutions to specific problems in extremal combinatorics. The obtained insights will also be combined with methods from discrete optimization and logic to provide new algorithmic frameworks.;1386859;1386859;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF WARWICK;UK;;; 194326;645463;U-Test;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Testing Cyber-Physical Systems under Uncertainty: Systematic, Extensible, and Configurable Model-based and Search-based Testing Methodologies;1/01/2015;31/12/2017;;"Uncertainty is intrinsic in Cyber-Physical Systems (CPSs) due to novel interactions of embedded systems, networking equipment, cloud infrastructures, and humans. CPSs have become predominant in critical domains and necessitate the implementation of proper mechanisms to deal with uncertainty during their operation at an acceptable cost avoiding unwarranted threats to its users and environment. One way to guarantee the correct implementation of such mechanisms is via automated and systematic Model-Based Testing (MBT)a way of improving dependability.
U-Test will improve the dependability of CPSs by defining extensible MBT frameworks supporting holistic MBT of CPSs under uncertainty in a cost-effective manner. More specifically our objectives are: 1) Provide a comprehensive and extensible taxonomy of uncertainties classifying uncertainties, their properties, and relationships; 2) An Uncertainty Modelling Framework (UMF) to support modelling uncertainties at various levels relying on exiting modelling/testing standards; 3) Defining an intelligent way to evolve uncertainty models developed using UMF towards realistic unknown uncertainty models using search algorithms (e.g., Genetic Algorithms); 4) Generating cost-effective test cases from uncertainty and evolved models.
U-Test consortium encompasses domain experts from various facets of CPSs, i.e., software, embedded systems, distributed systems, and cloud infrastructure. We have chosen two case studies from diverse domains including Handling Systems and Geo Sports to assess the cost-effectiveness of U-Test. The solutions will be integrated into two key commercial tools available in the market: ModelBus/Fokus!MBT and CertifyIt. Moreover, the solutions will be deployed into the actual practise in addition to standardization to achieve a wider impact within Logistics, Geo Sports, and Healthcare domains and further facilitate interoperability among tools and technologies.";3713233,75;3713233,75;H2020-ICT-2014-1;RIA;OSLO MEDTECH FORENING;NO;"FUTURE POSITION X IDEELL FORENING;Vrmlands lns landsting;TECHNISCHE UNIVERSITAET WIEN;ULMA MANUTENCION S. COOP.;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;EASY GLOBAL MARKET SAS;SIMULA RESEARCH LABORATORY AS;IKERLAN SCL";"SE;AT;ES;DE;FR;NO"; 194230;644666;SUNFISH;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;SecUre iNFormation SHaring in federated heterogeneous private clouds;1/01/2015;31/12/2017;;"Today the European Public Sector Players lack the necessary infrastructure and technology to allow them to integrate their computing clouds. Furthermore, legislative barriers often make it difficult to use available commercial technological solutions. The SUNFISH project aims to provide a specific and new solution to face these issues. SUNFISH will enable the secure federation of private clouds based on the Public Sector needs: federated private clouds belonging to different Public Sector Entities will be able to share data and services transparently, while maintaining required security levels.
The SUNFISH project will develop and integrate software enabling secure cloud federation as required by European Public Sector bodies. The project will achieve this by meeting firstly the specific challenges faced by the Maltese and Italian Ministries of Finance, as well as by the UK Regional Cyber Crime Units, the three SUNFISH selected use cases. Solutions will be developed to be usable by other European Public Organisations, and potentially also by private sector players.
SUNFISH will improve security in federated cross-border clouds, boosting the development of a cloud computing market in sectors where privacy and control of information propagation are essential (e.g., e-government, e-health etc.) while encouraging a better resource utilisation of Public Administration cloud infrastructure.
The secure system for federated private clouds developed through the project will guarantee a high level of safety, a continuous monitoring of inter-cloud communications, and the ability to roll out services cheaply, in a fast, flexible and secure way even between different private clouds.
The SUNFISH project aims to reduce the management cost of private clouds owned by Public Administrations, and - beyond pure costs savings to accelerate the transition to 21st century interoperable and scalable public services, boosting enforcement of the European Digital Single Market.";4520047,5;4520029;H2020-ICT-2014-1;RIA;MINISTERO DELL'ECONOMIA E DELLE FINANZE;IT;"CYBERNETICA AS;TECHNISCHE UNIVERSITAET GRAZ;PRICEWATERHOUSECOOPERS ADVISORY SPA;POLICE AND CRIME COMMISSIONER FOR THAMES VALLEY;MINISTRY FOR FINANCE;MALTA INFORMATION TECHNOLOGY AGENCY;ZENTRUM FUR SICHERE INFORMATIONSTECHNOLOGIE - AUSTRIA;UNIVERSITY OF SOUTHAMPTON;IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA";"EE;AT;IT;UK;MT;IL"; 194483;647067;BIOLOCHANICS;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine;1/05/2015;30/04/2020;;Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.;1999396;1999396;ERC-2014-CoG;ERC-COG;ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS;FR;CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU;FR; 194261;644906;AEGLE;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;AEGLE (Ancient Greek: ?????) An analytics framework for integrated and personalized healthcare services in Europe;1/03/2015;31/08/2018;;"The data generated in the health domain is coming from heterogeneous, multi-modal, multi-lingual, dynamic and fast evolving medical technologies. Today we are found in a big health landscape characterized by large volume, versatility and velocity (3Vs) which has led to the evolution of the informatics in the big biodata domain. AEGLE project will build an innovative ICT solution addressing the whole data value chain for health based on: cloud computing enabling dynamic resource allocation, HPC infrastructures for computational acceleration and advanced visualization techniques. AEGLE will:
- Realize a multiparametric platform using algorithms for analysing big biodata including features such as volume properties, communication metrics and bottlenecks, estimation of related computational resources needed, handling data versatility and managing velocity
- Address the systemic health big bio-data in terms of the 3V multidimensional space, using analytics based on PCA techniques
- Demonstrate AEGLEs efficiency through the provision of aggregated services covering the 3V space of big bio-data. Specifically it will be evaluated in: a)big biostreams where the decision speed is critical and needs non-linear and multi-parametric estimators for clinical decision support within limited time, b)big-data from non-malignant diseases where the need for NGS and molecular data analytics requires the combination of cloud located resources, coupled with local demands for data and visualization, and finally c)big-data from chronic diseases including EHRs and medication, with needs for quantified estimates of important clinical parameters, semantics extraction and regulatory issues for integrated care
- Bring together all related stakeholders, leading to integration with existing open databases, increasing the speed of AEGLE adaptation
- Build a business ecosystem for the wider exploitation and targeting on cross-border production of custom multi-lingual solutions based on AEGLE.";6079642,5;5230698,75;H2020-ICT-2014-1;IA;EXODUS ANONYMOS ETAIREIA PLIROFORIKIS;EL;"ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;MAAT FRANCE SARL;UNIVERSITA VITA-SALUTE SAN RAFFAELE;Uppsala universitet;CROYDON HEALTH SERVICES NATIONAL HEALTH SERVICE TRUST;KINGSTON UNIVERSITY HIGHER EDUCATION CORPORATION;GLOBAZ, S.A.;ERASMUS UNIVERSITEIT ROTTERDAM;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS;MAXELER TECHNOLOGIES LIMITED;TIME.LEX;PANEPISTIMIAKO GENIKO NOSOKOMEIO IRAKLEIOU";"EL;FR;IT;SE;UK;PT;NL;BE"; 194415;646125;ELSA;SIGNED;"H2020-EU.3.;H2020-EU.3.3.";LCE-08-2014;H2020;Energy Local Storage Advanced system (ELSA);1/04/2015;31/03/2018;;"Integration of distributed small/medium size storage systems can allow operating distribution grids much more flexibly, thus realizing smart grid features like local demand-supply balancing, congestion relief, peak shaving and effective RES integration.

However, few technologically mature decentralized storage systems are commercially available today at affordable prices, while both viable business models and the underlying legal and regulatory framework are lagging behind.

As an answer ELSA will implement and demonstrate an innovative solution integrating low-cost second-life Li-ion batteries and other direct and indirect storage options, including heat storage, demand-side management, as well as use of intermittent RES.

The core idea is to consider Storage as a Service towards building and district managers for local energy management optimization, and towards DSO for enhanced network operations. ELSA will adapt, build upon, and integrate close-to-mature (TRL>=5) storage technologies and related ICT-based energy management systems for the management and control of local loads, generation and single or aggregated real or virtual storage resources, including demand response, in buildings, districts and distribution grids.

Data models ensuring interoperability among building, districts and DSOs and novel business models enabled by energy storage as-a-service will be developed.

Different configurations will be demonstrated along six test sites, where a set of different storage technologies will be integrated. Safety issues and social acceptance will be dealt with by communication and product reliability demonstration.
A technical, economic and environmental validation, involving relevant stakeholders, will be carried out to nurture the European-wide replication of the ELSA concept, prepare the ground for a concrete roll out of the resulting TRL9 technologies and provide input for regulatory framework adaptation.";13144250;9861612,5;H2020-LCE-2014-3;IA;BOUYGUES ENERGIES & SERVICES;FR;"UNITED TECHNOLOGIES RESEARCH CENTRE IRELAND, LIMITED;ENGINEERING - INGEGNERIA INFORMATICA SPA;B.A.U.M. CONSULT GMBH;ASM TERNI SPA;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;ALLGAUER UBERLANDWERK GMBH;RENAULT SAS;Nissan West Europe SAS;Gateshead College";"IE;IT;DE;FR;UK"; 194236;644704;SMARTSET;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;High Performance Low Cost Virtual Studios for Creative Industries SMEs;1/01/2015;31/12/2016;;"The vision in project SmartSet is to develop a low cost virtual studio solution that will have the same quality and functionality of high cost solutions used by large broadcast companies so that the SmartSet solution will:
A. Increase the competitiveness of the European creative industries, particularly in the broadcast media sector;
B. Contribute to expanding a vibrant EU technological ecosystem for the creative industries' needs and foster exchanges between the creative industries SMEs and providers of ICT innovative solutions;
C. Stimulate the adoption and deployment of innovative ICT solutions by creative industries SMEs, particularly in the broadcast media and content production sector.
Creative industry SMEs such as regional and local TV stations, production companies are at a disadvantage when it comes to access to cost-effective virtual studio technology. To realise the vision in project SmartSet the objectives for this Innovation Action are:
1. Formulate and implement a stakeholder consultation process to support creative industry SMEs in leveraging emerging ICT technologies for the development of innovative products, tools, applications and services with high commercial potential.
2. Devise mechanisms to verify that user requirements are being met and the innovation potential can be clearly demonstrated.
3. Define and integrate a novel state of the art graphics engine with advanced image and video processing capabilities into a simplified and inexpensive self-contained SmartSet hardware platform.
4. Build a validation environment to ensure user requirements are central to system performance and are incorporated into the design.
5. Refine the SmartSet solution according validation results and prepare bug-free solution for commercialisation.
6. Create and implement a dissemination strategy and plan designed to generate a critical mass of interest in the SmartSet solution.
7. Design and implement an exploitation strategy and business modelling process";1352756,25;1078659;H2020-ICT-2014-1;IA;BRAINSTORM MULTIMEDIA S.L.;ES;"BONUM TV KOZHASZNU NONPROFIT KFT;Hallingdoelen AS;LAPIN AMMATTIKORKEAKOULU OY;UNIVERSITAT POLITECNICA DE VALENCIA;REMAR ESPANA (REHABILITACION DE MARGINADOS);JOULUPUKKI TV OY";"HU;NO;FI;ES"; 194523;647704;DiODe;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Distributed Algorithms for Optimal Decision-Making;1/08/2015;31/07/2020;;"This grant will develop and translate a unifying framework for optimal decision-theory, and observations of natural systems, to design distributed algorithms for decentralised decision-making. This will enable a technological step-change in techniques for controlling distributed systems, primarily demonstrated during the grant by decentralised control of robot swarms. These algorithms and associated methodology will also provide hypotheses and tools to change the way scientists think about and interrogate natural decision mechanisms, from intracellular regulatory networks, via neural decision circuits, to decision-making populations of animals. Specific objectives are:

1. Distributed value-sensitive decision-making: undertake optimality analyses of the applicants existing decentralised decision-making algorithms based on observations of collective iterated voting-processes in honeybees, and extend these.

2. Distributed sampling and decision-making: design distributed mechanisms that implement optimal compromises between sampling information and making decisions based on that information.

3. Individual-confidence and distributed decision-making: translate machine learning theory to collective behaviour models, designing mechanisms in which weak decision-makers optimally combine their decisions to optimise group performance.

4. Optimal distributed decision-making in collective robotics: translate theory from objective 1 to 3 towards practical applications in artificial systems, demonstrated using collectively-deciding robots.

5. Development of tools for life scientists and validation of theoretical predictions in natural systems: interact with named collaborators to investigate identified decision mechanisms in single cells, in neural circuits, and in social groups. Develop accessible modelling tools to facilitate investigations by life scientists.";1413705;1413705;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF SHEFFIELD;UK;;; 194387;645763;INCAS;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Understanding institutional change in Asia: a comparative perspective with Europe;1/06/2015;31/05/2019;;"The project INCAS aims at creating a top-level research and advanced training network on institutional change in Asia, in comparative perspective with Europe. The coordinator, Ecole des Hautes Etudes en Sciences Sociales (France), promotes this network together with Oxford University, Freie Universitt Berlin, in collaboration with Waseda University (Japan). The partners have chosen Japan as a reference point because of its comparability with Europe as shown by previous studies, its historical influence on development and further institutional changes in Asia, and the expertise accumulated within our research team.

Our approach, which refers to the literature on comparative capitalism, is fundamentally interdisciplinary by nature, as it aims at gathering economists, economic historians, political economy specialists, sociologists, and lawyers, who are specialized in various fields such as finance, labor economics and sociology, Asian studies, etc. Our major aim is to propose a new theory of institutional change that better takes into account diverse dimensions that have been overlooked by previous attempts such as: the historical experience of institutional change in Asia that went hand in hand with growth and development; the relations between (especially financial) liberalization and corporate diversity; the interaction between political economy, socio-economic and legal variables. It requires not only the interdisciplinary approach described above but also an empirical investigation that mobilizes a database for corporate characteristics.

Each institutional member of INCAS has developed its own research strategy on a similar object (institutional change in Asia and Europe) and the goal of this project is to organize a knowledge transfer within our team (and later outside the research team) in order to build a comprehensive research program.";778500;778500;H2020-MSCA-RISE-2014;MSCA-RISE;ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES;FR;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;FREIE UNIVERSITAET BERLIN";"UK;DE"; 194194;644344;DiDIY;SIGNED;H2020-EU.2.1.1.;ICT-31-2014;H2020;Digital Do It Yourself;1/01/2015;30/06/2017;;"Digital do it yourself (DiDIY) is a new socio-technological phenomenon in which the widespread availability of digital devices supporting the convergence of physical and informational components and the growing accessibility of knowledge and data through open online communities presage scenarios in which the distinction between users and producers of physical artefacts is fuzzy and new opportunities and threats emerge. DiDIY-related technologies and social practices amplify the creativity and skills of individuals who affordably develop digitally self-made objects, e.g., unique-by-design objects designed by 3D modelling software and generated by 3D printers or networked smart objects equipped with microcontrollers dealing with context information via sensors and actuators. Two network effects catalyse DiDIY: what is custom produced by an individual could be the outcome of contributions from a world-wide community of developers sharing their interest towards open innovation, thus operating as knowledge multiplier; what is made available here and now by a smart object could be the aggregation of signals from a set of sources in the network, thus operating as information extender.
In this (presumed) industrial revolution the project aims at:
* setting a conceptual framework to explore the impact of DiDIY,
* producing information, models and guidelines to support education and policy making on DiDIY that, while enabled by technology, should be driven by social and cultural strategies.
The project will study how DiDIY is
* reshaping organization and work, education and research,
* impacting on social and legal systems
* changing creative design and ethics.
The development of a systemic interpretation is the challenge for the multidisciplinary project team, which will collaboratively explore a complex phenomenon with implications on identity, privacy, reputation, responsibility and safety and will offer a roadmap fostering a DiDIY-based human-centric European development.";2081767,5;2081767,5;H2020-ICT-2014-1;RIA;UNIVERSITA' CARLO CATTANEO - LIUC;IT;"Amerikaniko Kollegio Anatolia;THE UNIVERSITY OF WESTMINSTER LBG;AB.ACUS SRL;THE MANCHESTER METROPOLITAN UNIVERSITY;POLITECNICO DI MILANO;STICHTING FREE KNOWLEDGE INSTITUTE";"EL;UK;IT;NL"; 194166;644187;RAGE;SIGNED;H2020-EU.2.1.1.4.;ICT-21-2014;H2020;Realising an Applied Gaming Eco-system;1/02/2015;31/01/2019;;"The EU based industry for non-leisure games (applied games) is an emerging business. As such, its still fragmented and needs critical mass to compete globally. Nevertheless its growth potential is widely recognised and even suggested to exceed the growth potential of the leisure games market.

RAGE will help to seize these opportunities by making available 1) an interoperable set of advanced technology assets tuned to applied gaming 2) proven practices of using asset-based applied games in various real-world contexts, 3) centralised access to a wide range of applied gaming software modules, services and resources, 4) an online social space (the RAGE Ecosystem) that arranges and facilitates collaboration that underlie progress and innovation, 5) workshops and online training opportunities for both developers and educators, 6) assets-based business cases that support the games industry at seizing new business opportunities, and 7) a business model and launch plan for exploiting the RAGE Ecosystem beyond the projects duration.

Intermediary organisations and education providers anticipate a wider exploitation of RAGE results among their end-users, which add up to over 1 million, and through disseminating RAGE in their partner networks. The game companies in RAGE anticipate adding RAGE-based products to their portfolio, in order to improve their competitive advantage by opening a new product line for applied games and developing new revenue streams.

Actual deployment of RAGE results will generate direct impact on the competitive positioning of the few thousand of European SMEs in the Applied Games market. Impacts from RAGE will be visible in terms of fulfilling new client needs by quicker and more challenging methods of skills acquisition, enabling new business models based on the usage of the assets repository and the Ecosystem, and in the strengthening collaboration across the entire Applied Games value chain.";8999942,5;8999942,5;H2020-ICT-2014-1;RIA;OPEN UNIVERSITEIT NEDERLAND;NL;"PlayGen Ltd;TECHNISCHE UNIVERSITAET GRAZ;HULL COLLEGE OF FURTHER EDUCATION;GAMEWARE EUROPE LIMITED;OKKAM SRL;FTK FORSCHUNGSINSTITUT FUR TELEKOMMUNIKATION UND KOOPERATION EV;UNIVERSITEIT UTRECHT;GROUPE RANDSTAD FRANCE;UNIVERSITATEA POLITEHNICA DIN BUCURESTI;THE UNIVERSITY OF BOLTON;INSTITUTO DO EMPREGO E FORMACAO PROFISSIONAL;INMARK EUROPA SA;INESC ID - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA;Ministrio da Justia;SOFIISKI UNIVERSITET SVETI KLIMENT OHRIDSKI;STICHTING PRAKTIJKLEREN;INMARK ESTUDIOS Y ESTRATEGIAS SA;NUROGAMES GMBH;BIP MEDIA SARL;UNIVERSIDAD COMPLUTENSE DE MADRID";"UK;AT;IT;DE;NL;FR;RO;PT;ES;BG"; 194278;645094;SEWA;SIGNED;H2020-EU.2.1.1.4.;ICT-22-2014;H2020;Automatic Sentiment Estimation in the Wild;1/02/2015;31/07/2018;;Automatic Sentiment Estimation in the Wild;3639875;3259250;H2020-ICT-2014-1;IA;IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE;UK;"PlayGen Ltd;REALEYES OU;UNIVERSITAT PASSAU";"UK;EE;DE"; 194319;645402;MIKELANGELO;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;MIcro KErneL virtualizAtioN for hiGh pErfOrmance cLOud and hpc systems;1/01/2015;31/12/2017;;MIKELANGELO is a project, targeted to disrupt the core underlying technologies of Cloud computing, enabling even bigger uptake of Cloud computing, HPC in the Cloud and Big Data technologies under one umbrella. The vision of MIKELANGELO is to improve responsiveness, agility and security of the virtual infrastructure through packaged applications, using lean guest operating system OSv and superfast hypervisor SuperKVM. In short, the work will concentrate on improvement of virtual I/O in KVM, using additional virtio expertise, integrated with the light-weight operating system OSv and with enhanced Security. The HPC in the Cloud focus will be provided through involvement of a large HPC centre, with the ability and business need to cloudify their HPC business. The Consortium consists of hand-picked experts (e.g., the original creator of KVM - Avi Kivity) who participate in the overall effort to reduce one of the last performance hurdles in the virtualisation (I/O). Other layers of inefficiency are addressed through OSv (thin operating system) and all packaged under the OpenStack or OpenNebula. Such approach will allow for use of MIKELANGELO stack on heterogeneous infrastructures, with high responsiveness, agility and better security. The targeted audience are primarily SMEs (e.g. simulation dependent SMEs). Finally, the use-cases have clear owners, thus directly contributing to the exploitation.;5993419;5993419;H2020-ICT-2014-1;RIA;XLAB RAZVOJ PROGRAMSKE OPREME IN SVETOVANJE DOO;SI;"GESELLSCHAFT FUR WISSENSCHAFTLICHE DATENVERARBEITUNG MBH GOTTINGEN;BEN-GURION UNIVERSITY OF THE NEGEV;INTEL RESEARCH AND DEVELOPMENT IRELAND LIMITED;HUAWEI TECHNOLOGIES DUESSELDORF GMBH;SCYLLA DB LTD;Universitaet Stuttgart;PIPISTREL PODJETJE ZA ALTERNATIVNO LETALSTVO DOO AJDOVSCINA;IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD";"DE;IL;IE;SI"; 194262;644925;CYCLONE;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Complete Dynamic Multi-cloud Application Management;1/01/2015;31/12/2017;;"Application service providers (ASPs) now develop, deploy, and maintain complex computing platforms within multiple cloud infrastructures to improve resilience, responsiveness and elasticity of their applications. The CYCLONE project targets the ASPs, providing them with software and tools that 1) facilitate the deployment, management, and use of their complex, multi-cloud applications and 2) enhance the end-to-end security and network management of those applications.

Using agile methodologies and continuous delivery, CYCLONE integrates and improves mature, open-source components, such as StratusLab, OpennNaaS, SlipStream, and TCTP. Participants from the bioinformatics and energy sectors will guide the initial platform development; use cases from additional sectors identified during the project will drive its subsequent evolution. Constant availability of the CYCLONE testbed allows all these users to rapidly prototype their complex cloud applications and to provide continuous feedback to the developers, thus validating the CYCLONE softwares design, implementation, and production quality.

CYCLONE allows ASPs to aggregate resources from multiple cloud providers (private and public) to improve the reliability of their applications through geographic redundancy, to enhance the user experience by placing services (and data) near their users, to lower barriers between cloud providers via a cloud deployment engine with appropriate resource abstractions, and to tailor intra- and inter-site networking resources. Coupled with application-level security features and trust bootstrapping mechanisms, CYCLONE allows ASPs to define their own innovative and secure cloud platform tailored to their needs and trusted by their users.";3843602;2846402;H2020-ICT-2014-1;IA;INTEROUTE S.P.A.;IT;"SIXSQ SARL;TECHNISCHE UNIVERSITAET BERLIN;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;QSC AG;FUNDACIO PRIVADA I2CAT, INTERNET I INNOVACIO DIGITAL A CATALUNYA;UNIVERSITEIT VAN AMSTERDAM";"CH;DE;FR;ES;NL"; 194215;644526;iCIRRUS;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;intelligent Converged network consolIdating Radio and optical access aRound USer equipment.;1/01/2015;31/12/2017;;"To meet the high throughput demands envisaged for 5G networks, with increased user densification and bandwidth-hungry applications, while at the same time reducing energy consumption, iCIRRUS proposes an intelligent Cloud-Radio Access Network (C-RAN) that brings together optical fibre technology, low-cost but highly flexible Ethernet networking, wireless resource management for device-to-device (D2D) communication (incl. the use of mm-wave spectrum) and the use of virtual mobiles in the cloud. The iCIRRUS C-RAN introduces the use of Ethernet in the fronthaul/midhaul (for radio signal transport), to minimise cost and make available pluggable and in-device monitoring, and intelligent processing to enable self-optimizing network functions which maximise both network resource utilisation and energy efficiency. To exemplify the attractiveness of the proposition, iCIRRUS focusses on D2D communication in the wireless domain, an important work area in current standardisation, where low latency is known to be a significant factor. The latency and jitter in the iCIRRUS Ethernet-based C-RAN will be an important focus of the research work in the project, with current 5G performance targets in mind; for D2D communications, the task will be to minimise control latency and overhead. A major obstacle for C-RANs is the bit-rate of the digitised radio signals that would be required for 5G of the order of 100 Gb/s and iCIRRUS will examine the architectural and technological questions surrounding this requirement. Wireless resource management will be investigated, together with mobile device caching and mm-wave D2D mesh networks, to reduce latency as well as load on the infrastructure. Finally, the intelligent network functions in ICIRRUS can interact with mobile cloud processing, and further offloads of infrastructure communications can be realised through virtualising mobiles in the cloud as clones, and performing communication tasks between clones.";3832196,25;3832195;H2020-ICT-2014-1;RIA;UNIVERSITY OF KENT;UK;"ADVA OPTICAL NETWORKING SE;PRIMETEL PLC;INTERDIGITAL EUROPE LTD;IAF INSTITUT FUER ANGEWANDTE FUNKSYSTEMTECHNIK GmbH;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;UNIVERSITY OF ESSEX;WELLNESS TELECOM SL;VIAVI SOLUTIONS UK LIMITED;ORANGE SA;TELEKOM SLOVENIJE DD;ADVA OPTICAL NETWORKING LIMITED";"DE;CY;UK;ES;FR;SI"; 194400;645865;SPOOC;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Automated Security Proofs of Cryptographic Protocols: Privacy, Untrusted Platforms and Applications to E-voting Protocols;1/09/2015;31/08/2020;;"The rise of the Internet and the ubiquity of electronic devices has deeply changed our way of life. Many face to face and paper transactions have nowadays digital counterparts: home banking, e- commerce, e-voting, etc. The security of such transactions is ensured by the means of cryptographic protocols. While historically the main goals of protocols were to ensure confidentiality and authentication the situation has changed. The ability of people to stay connected constantly combined with ill-conceived systems seriously threatens peoples privacy. E-voting protocols need to guarantee privacy of votes, while ensuring transparency of the voting process; RFID and mobile telephone protocols have to guarantee that people cannot be traced. Moreover due to viruses and malware, personal computers and mobile phones must not be considered anymore to be trustworthy; yet they have to be used to execute protocols that need to achieve security goals. To detect flaws, prove the security of protocols and propose new design principles the Spooc project will develop solid foundations and practical tools to analyze and formally prove security properties that ensure the privacy of users as well as techniques for executing protocols on untrusted platforms. We will

- develop foundations and practical tools for specifying and formally verifying new security properties, in particular privacy properties;

- develop techniques for the design and automated analysis of protocols that have to be executed on untrusted platforms;

- apply these methods in particular to novel e-voting protocols, which aim at guaranteeing strong security guarantees without need to trust the voter client software.

The Spooc project will significantly advance formal verification of security protocols and contribute to the development of a rich framework that provides techniques and tools to analyze and design security protocols guaranteeing users privacy and relaxing trust assumptions on the execution platforms.";1903500;1903500;ERC-2014-CoG;ERC-COG;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;FR;;; 194309;645331;EurEyeCase;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Use Case for European Robotics in Ophthalmologic Micro?Surgery;1/01/2015;31/12/2017;;EurEyeCase combines cutting?edge European robotic technology and creates an integrated setup for the very challenging use case of vitreoretinal eye surgery. Nowadays, a selected number of highly?skilled ophthalmologists are treating large numbers of patients that suffer from various types of vitreoretinal eye diseases. The majority of these intra?ocular interventions lie on or even beyond the boundaries of human skills as they pose extreme requirements in terms of manipulation and positioning precision. As a result, current treatments are characterized by moderate success rates and even an inability to adequately treat some common diseases. As a consequence, a large group of patients is left untreated or receives suboptimal treatment only. Robotic technology can and is likely to put an end to the current status?quo. Starting from existing hardware, knowledge and IP and in close collaboration with medical partners, EurEyeCase will build up and validate a convincing robot?assisted operation suite, which will help surgeons in treating a selection of particular demanding vitreoretinal procedures including the treatment of retinal vein/artery occlusion through cannulation and epiretinal membrane treatment. Current laboratory setups will be studied in detail, augmented and tailored for successful integration into the surgical workflow. Novel sensing technologies will be further developed and integrated with advanced control methods to deliver unprecedented levels of safety and performance. In-depth evaluation of the setup in different directions, i.e, performance, usability and clinical relevance, as well as the first steps to transfer the most challenging developments to the next phase of product development are key aspects of the project. EurEyeCase will demonstrate how medical robotics technology can boost success rates of urgent and critical surgical interventions and paves the way for novel promising treatment methods with demonstrated improvements in patient outcome;3274526,25;2648314;H2020-ICT-2014-1;IA;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;"MEDICAL ROBOTIC TECHNOLOGIES BV;INTEGRATED MICROSYSTEMS AUSTRIA GMBH;OPTOMEDICAL TECHNOLOGIES GMBH;MEDIZINISCHES LASERZENTRUM LUBECK GMBH;UNIVERSITA DEGLI STUDI DI MILANO;PRECEYES BV;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;STICHTING OOGZIEKENHUIS ROTTERDAM;TECHNISCHE UNIVERSITEIT EINDHOVEN";"NL;AT;DE;IT;CH"; 194246;644801;EU-XCEL;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;Accelerating Entrepreneurial Learning across European Regions;1/01/2015;30/06/2017;;"Accelerating Entrepreneurial Learning across European Regions
There are a number of profound challenges facing the European Union. Despite the single market being in existence for quite some time, start-ups and entrepreneurs tend not to think European wide and business scaling is very fragmented. The entrepreneurial ecosystem is also fragmented and not joined up between countries. Unemployment levels are very high, with high rates of over 50% of under-25s among Mediterranean countries, such as Spain and Greece. Entrepreneurship in Europe lags behind the US, in terms of effectiveness, scale and impact.

Set in this context, the focus of the proposal is to develop more ICT entrepreneurs and this is adopted as the key objectives, which is the core outcomes required from the Horizon 2020 ICT 35 call. Specifically this programme sets out to train ICT entrepreneurs to be incubator ready and this is informed by research into current practice in incubators across Europe. The Horizon 2020 is an ideal opportunity for Europe to enable a different breed of European ICT entrepreneurs. Some of the characteristics of achieving this include the need to spend an appropriate amount of time to allow ICT entrepreneurs develop the commercial skills, as well as the technical proposition.

This project will develop a network of ICT entrepreneurship creative physical and virtual spaces and coordinate European wide intensive entrepreneurial action training events called Start-up Scrums between consortia members with international teams. The programme will cultivate a European entrepreneurial mind-set and pilot a Born European Enterprise annual event. It is recognised that ICT enterprises take time to develop the technology. The proposal sets out to engage with 300 ICT students using an intensive training package over 4 months, starting with the start-up Scrums, continuing with virtual support via the EU Virtual Incubator and culminating with the best teams competing in the Born European Enterprise Challenge. A key element of the programme is student exchange as well as staff exchange, which will enable cross-fertilisation.

This proposal is thematically focused on creating Born European Enterprises and fulfills the three objectives of the Horizon 2020 2014 ICT 35 a, b & c call: a pan European competition (across over 10 MS), summer schools (Start-up Scrums) and supporting the creation of new virtual and physical ICT creative spaces (Athens). The ICT teams will have opportunities to pursue their new ventures in a number of European incubators, within the consortia. The action will combine ICT physical and virtual entrepreneurship spaces, which facilitate European collaboration and on-going support after workshop events.";1791219;1791219;H2020-ICT-2014-1;IA;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;"HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN MUNCHEN;UNIVERSIDAD POLITECNICA DE CARTAGENA;DANMARKS TEKNISKE UNIVERSITET;FUNDACJA UNIWERSYTETU IM ADAMA MICKIEWICZA W POZNANIU;ATHENS UNIVERSITY OF ECONOMICS AND BUSINESS - RESEARCH CENTER";"DE;ES;DK;PL;EL"; 194508;647755;DYNPOR;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;First principle molecular dynamics simulations for complex chemical transformations in nanoporous materials;1/08/2015;31/07/2020;;"Chemical transformations in nanoporous materials are vital in many application domains, such as catalysis, molecular separations, sustainable chemistry,. Model-guided design is indispensable to tailoring materials at the nanometer scale level.
At real operating conditions, chemical transformations taking place at the nanometer scale have a very complex nature, due to the interplay of several factors such as the number of particles present in the pores of the material, framework flexibility, competitive pathways, entropy effects, The textbook concept of a single transition state is far too simplistic in such cases. A restricted number of configurations of the potential energy surface is not sufficient to capture the complexity of the transformation.

My objective is to simulate complex chemical transformations in nanoporous materials using first principle molecular dynamics methods at real operating conditions, capturing the full complexity of the free energy surface. To achieve these goals advanced sampling methods will be used to explore the interesting regions of the free energy surface. The number of guest molecules at real operating conditions will be derived and the diffusion of small molecules through pores with blocking molecules will be studied. New theoretical models will be developed to keep track of both the framework flexibility and entropy of the lattice.

The selected applications are timely and rely on an extensive network with prominent experimental partners. The applications will encompass contemporary catalytic conversions in zeolites, active site engineering in metal organic frameworks and structural transitions in nanoporous materials, and the expected outcomes will have the potential to yield groundbreaking new insights.

The results are expected to have impact far beyond the horizon of the current project as they will contribute to the transition from static to dynamically based modeling tools within heterogeneous catalysis";1993750;1993750;ERC-2014-CoG;ERC-COG;UNIVERSITEIT GENT;BE;;; 194372;645722;NonMinimalHiggs;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Non Minimal Higgs;1/06/2015;31/05/2019;;"On July 4th CERN has announced the discovery of a scalar particle at the Large Hadron Collider (LHC), later identified as the Higgs boson. This scientific breakthrough was accomplished due to the joint efforts of thousands of scientists from all around the globe. This long awaited discovery increased our understanding of the world, providing an explanation for the mechanism from which all elementary particles acquire mass. However, there are still fundamental questions awaiting a clear answer: which model better describes nature when all observed properties of this new particle are taken into consideration? Will these new models help to solve other outstanding problems in elementary particle physics? The goal of this project is to look for answers to these crucial questions regarding our understanding of nature.
In order to address the problem we have gathered a group of people with complementary expertises that range from model builders to high-energy tool developers who will finally make the connection to the LHC's experimental collaborations. We expect that this interaction between the different nodes of this international collaboration will result in a database together with high-energy tools where a number of models will be readily available for testing by the experimental groups at the LHC and future colliders.
The staff exchange will be planned according to the needs of the project. There have been collaborations in the past between some of the nodes. We now expect that the proposed staff exchange will enhance this Higgs physics network, with an effective skills development both for experienced and early stage researchers. Finally we foresee that the project will not only have an impact on European science but will also contribute to bring together different cultures with a very positive outcome for society as a whole.";328500;301500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITY OF SOUTHAMPTON;UK;"HELSINGIN YLIOPISTO;INSTITUTO SUPERIOR DE ENGENHARIA DE LISBOA;Uppsala universitet;Universit Paris-Sud";"FI;PT;SE;FR"; 194468;646713;RICH;SIGNED;H2020-EU.1.4.;INFRASUPP-8-2014;H2020;Research Infrastructures Consortium for Horizon 2020;1/12/2014;30/11/2018;;"The National Contact Points perform valuable services in guiding and supporting national applicants in preparing proposals for Horizon 2020 funding. We expect that through an enhanced transnational cooperation and networking between National Contact Points for research infrastructures, a higher quality of their consulting services and thus of proposals and projects can be achieved. Therefore, the specific objective of RICH (Research Infrastructures COnsortium for Horizon 2020) is to facilitate trans-national co-operation between NCPs for research infrastructures with a view to identifying and sharing good practices and raising the general standard of support to programme applicants, taking into account the diversity of actors that make up the constituency of the Research Infrastructures Part.
By involving 11 formally nominated National Contact Points RICH will be able to will extensively involve the NCPs that have decided to become associated partner also thanks to the setting up of a liaison office.
Concretely, activities of RICH towards this goal include, amongst others, multi-level trainings and tripling schemes, experts seminars, simposia and wide promotion of Transnational Access and Service (TAS) as well as a wide range of other communication and dissemination tools and platforms.
RICH work programme is designed to achieve an improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls, lowering the entry barriers for newcomers, and raising the average quality of proposals submitted.";2157141,25;1996828,5;H2020-INFRASUPP-2014-1;CSA;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;IT;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;INSTITUTO DE SALUD CARLOS III;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;DIENST VOOR WETENSCHAPPELIJKE EN TECHNISCHE INFORMATIE- SERVICE D'INFORMATION SCIENTIFIQUE ET TECHNIQUE;VEREIN EURESEARCH;GENIKI GRAMMATIA EREVNAS KAI TECHNOLOGIAS;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"DE;AT;ES;FR;CZ;PL;BE;CH;EL;PT"; 194221;644606;Photonics4All;SIGNED;H2020-EU.2.1.1.6.;ICT-26-2014;H2020;EU-wide outreach for promoting photonics to young people, entrepreneurs and the general public;1/01/2015;31/12/2016;;"This project responds to the ICT-26-c call which is focusing on the EU-wide outreach for promoting photonics to young people, entrepreneurs and the general public. The project's acronym is Photonics4all and its duration will be two years. Within the framework of the proclaimed International Year of Light and Light-based Technologies (IYL 2015) by the United Nations this project shall mainly improve the public image of photonics and increase the public awareness of the importance of photonics, especially regarding current societal challenges like health and well-being, safety and security etc.

The uniqueness of Photonics4all is on the one hand the development of new promotional tools and on the other hand the performance of various outreach activities. The main goal of Photonics4all will be to sensitize and to arouse interest of the mentioned target groups for photonics technology in many European countries in order to achieve an EU-wide outreach.
These tools will be developed and implemented into many promotional activities which will be conducted during the project as well.

Strong European collaborations, based on cluster activities, shall increase the interest of young people, entrepreneurs and the general public and thereby generate more qualified workforce and young academics, more innovative applications and an increased awareness of photonics. This will be reached providing an excellent consortium of 9 photonics related partners (OND, AIDO, OV, EaPS, PhAu, TUD, UoS, ILC, CNR) from 9 different European countries. In addition, the coordinator of the project is representing an organisation which has a great expertise in managing European projects (SEZ). Thus this project will be carried out by 10 European organisations with excellent connections to relevant networks.";997953;997953;H2020-ICT-2014-1;CSA;STEINBEIS 2I GMBH;DE;"OPTICSVALLEY-AU SERVICE DE L OPTIQUE DE L ELECTRONIQUE ET DE L INGENIERIE LOGICIELLE EN ILE-DE-FRANCE;MEDZINARODNE LASEROVE CENTRUM;PHOTONICS AUSTRIA - PLATTFORM ZUR FORDERUNG DER OSTERREICHISCHEN INTERESSEN IM BEREICH PHOTONIKEICH PHOTONIK;CONSIGLIO NAZIONALE DELLE RICERCHE;STEINBEIS INNOVATION GGMBH;TECHNISCHE UNIVERSITEIT DELFT;UNIVERSITY OF SOUTHAMPTON;ASOCIACION INDUSTRIAL DE OPTICA, COLOR E IMAGEN;EKONOMISKA FORENINGEN PHOTONICSWEDEN;OPTECNET DEUTSCHLAND EV";"FR;SK;AT;IT;DE;NL;UK;ES;SE"; 194493;647292;MathModExp;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;The Evolution of Competition and Cooperation: how polymorphisms in microbial populations optimise virulence and mediate drug resistance;1/09/2015;31/08/2020;;"Microbes form intricate communities where multiple strains and species communicate cooperate and compete, they can cause life-threatening diseases and destroy our food sources. Metabolism is key to these interactions, yet the way microbes acquire and utilise nutrients is often overlooked in evolutionary studies of pathogenicity, virulence and antibiotic resistance. I will address this by quantifying how microbial community composition is determined by the metabolism, genetics and physiology of individual players, establishing principles by which microbial composition affects virulence and antimicrobial resistance.
Competition for resources is the most basic of ecological interactions, fundamental because one cell directly impacts the fitness of others. It is only by incorporating nutrient acquisition and utilisation into studies of virulence and antibiotic resistance that we can predict, and ultimately control, the evolutionary response of microbes to resource stresses, antimicrobials and host defences. I will address two outstanding problems:
Challenge one: Pathogens must acquire nutrients from their hosts, but what combination of different resource acquisition and utilisation strategies maximise population success and, therefore, virulence?
Challenge two: Antibiotics can perturb the composition of polymicrobial communities from susceptible to resistant species but how is this shift mediated by resource utilisation strategies?
Fully integrating empirical data and theory, concepts from ecology and evolutionary dynamics will be key. We will formulate new theoretical tools that allow us to make predictions that will be fully challenged by data, both in vitro and in vivo. This research will exploit advances in the molecular genetics of important plant and human pathogens and we will use them to synthesise polymorphic microbial populations and polymicrobial communities. We will dissect these to understand what makes microbials so resilient to the challenges they face.";1968392,05;1968392,05;ERC-2014-CoG;ERC-COG;THE UNIVERSITY OF EXETER;UK;;; 194179;644268;ETexWeld;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Welding of E-Textiles for Interactive Clothing;1/01/2015;31/12/2018;;"The new field of science dealing with implementation of electronics to textiles in combination with informatics is known as e-textiles. This project proposal leads to knowledge transfer among partners in order to develop innovative e-textile products for interactive protective clothing and footwear using welding technologies by bringing experts from different countries, sectors and disciplines together to focus their effort in innovative e-textile product designs.
Within this context, the project aims to develop novel e-textile structures including transmission lines, sensors, actuators, microprocessors, personalized algorithms, on-body computing and user feedbacks in order to make a breakthrough towards development of interactive protective clothing and footwear that able to monitor health, activity, position of the user in the environmental risky situations, the welding technologies will be mainly used in three concepts:
I. Designing of transmission lines of e-textile structures;
II. Integration of electronic elements (different sensors, actuators, microprocessors, data transmission and power supply systems) to textile structures;
III. Design and development of whole e-textile system for protective clothing applications including interactive protective garments and shoes.
Thus, project draws on strong transitions of textiles, electronics and informatics researches and is internationally acknowledged for its pioneering contributions to e-textile researches through the industry-academia cooperation. This will not only help to develop future generations of entrepreneurial researchers more capable of contributing effectively to the knowledge-based e-textile research area, within and between public and private sectors, but also add to the intersectorial and trans-national employability of these researchers as well as to the attraction of young people to a research career on textile/electronics areas.";1206000;913500;H2020-MSCA-RISE-2014;MSCA-RISE;ISTANBUL TEKNIK UNIVERSITESI;TR;"TEXNOLOGIES FOTONIKON KAI HLEKTRONIKON SYSTHMATVN AE;THE UNIVERSITY OF MANCHESTER;KIVANC KIMYA SANAYII VE TICARET ANONIM SIRKETI;INLAS INTELEKTUALNA LASTNINA IN SVETOVANJE DOO;Technological Educational Institute of Piraeus;ECOLE NATIONALE SUPERIEURE DES ARTS ET INDUSTRIES TEXTILES;UNITED MEDICAL INNOVATION LTD";"EL;UK;TR;SI;FR"; 194200;644385;PERGAMON;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;PERvasive Serious GAMes suppOrted by Virtual CoachiNg;1/01/2015;31/12/2016;;"PERGAMON aims to facilitate the matching between providers of innovative ICT technologies on the supply side and the creative industry operating in the field of serious games on the demand side. Specifically, the PERGAMON project aims to support the adoption by the creative industry of an innovative technology framework for the development of pervasive serious games able to provide a personalized gaming experience.

PERGAMONs main objectives are:
to implement and pilot test a gaming framework that helps the creative SME to develop pervasive serious games in an effective and efficient way
to develop new emotional and engaging serious game concepts integrated with personalized user assistance by means of a Virtual Coach and Artificial Intelligent functions.
to set up a flexible gaming framework that is expandable so that additional services can be added at any time
to connect the creative SME with the business network operating into the serious games international market
to facilitate strategic business alliance between creative SMEs and providers of leading edge ICT technologies.

The pervasive serious game framework will be built on the following components:
a Sensor Network for monitoring the player by means of wireless sensors
a virtual Coach delivering personalized assistance to the player in the real life
a Game Guide that adapts the challenges presented in the game and their level of difficulty to the data collected by the sensor network and to the user's interaction with the game itself
a Dashboard accessible through a web site
social and pervasive game dynamics that encourages players to engage in challenges of increasing difficulty.

The new concept of digital game can be used in various application contexts (health care, corporate training, education, government etc.) but will initially be implemented and tested for the empowerment of chronic disease patients.";1064195;886810;H2020-ICT-2014-1;IA;GRIFO MULTIMEDIA SRL;IT;"COVENTRY UNIVERSITY;AISOLVE LIMITED;STICHTING ZIEKENHUIS GELDERSE VALLEI;UNIVERSITEIT TWENTE";"UK;NL"; 194263;644938;SARAFun;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Smart Assembly Robot with Advanced FUNctionalities;1/03/2015;28/02/2018;;"While Industrial robots are very successful in many areas of industrial manufacturing, assembly automation still suffers from complex time consuming programming and the need of dedicated hardware. ABB has developed FRIDA (Friendly Robot for Industrial Dual Arm Assembly), a collaborative inherently safe assembly robot that is expected to reduce integration costs significantly by offering a standardized hardware setup and simple fitting of the robot into existing workplaces. Internal Pilot testing at ABB has however shown that when FRIDA is programmed with traditional methods the programming time even for simple assembly tasks will remain very long.
The SARAFun project has been formed to enable a non-expert user to integrate a new bi-manual assembly task on a FRIDA robot in less than a day. This will be accomplished by augmenting the FRIDA robot with cutting edge sensory and cognitive abilities as well as reasoning abilities required to plan and execute an assembly task.
The overall conceptual approach is that the robot should be capable of learning and executing assembly tasks in a human like manner. Studies will be made to understand how human assembly workers learn and perform assembly tasks. The human performance will be modelled and transferred to the FRIDA robot as assembly skills. The robot will learn assembly tasks, such as insertion or folding, by observing the task being performed by a human instructor. The robot will then analyze the task and generate an assembly program, including exception handling, and design 3D printable fingers tailored for gripping the parts at hand. Aided by the human instructor, the robot will finally learn to perform the actual assembly task, relying on sensory feedback from vision, force and tactile sensing as well as physical human robot interaction. During this phase the robot will gradually improve its understanding of the assembly at hand until it is capable of performing the assembly in a fast and robust manner.";4037266,25;4037265,5;H2020-ICT-2014-1;RIA;ABB AB;SE;"ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;KUNGLIGA TEKNISKA HOEGSKOLAN;FUNDACION TECNALIA RESEARCH & INNOVATION;UNIVERSITAET BIELEFELD;LUNDS UNIVERSITET";"EL;SE;ES;DE"; 194247;644814;PaaSword;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;A Holistic Data Privacy and Security by Design Platform-as-a-Service Framework Introducing Distributed Encrypted Persistence in Cloud-based Applications;1/01/2015;31/12/2017;;"The vision of PaaSword is to maximize and fortify the trust of individual, professional and corporate customers to Cloud -enabled services and applications, to safeguard both corporate and personal sensitive data stored on Cloud infrastructures and Cloud-based storage services, and to accelerate the adoption of Cloud computing technologies and paradigm shift from the European industry. Thus, PaaSword will introduce a holistic data privacy and security by design framework enhanced by sophisticated context-aware policy access models and robust policy access, decision, enforcement and governance mechanisms, which will enable the implementation of secure and transparent Cloud-based applications and services that will maintain a fully distributed and totally encrypted data persistence layer, and, thus, will foster customers' data protection, integrity and confidentiality, even in the case wherein there is no control over the underlying third-party Cloud resources utilized.
In particular, PaaSword intends not only to adopt the CSA Cloud security principles, but also to extend them by capitalizing on recent innovations on (a) distributed encryption and virtual database middleware technologies that introduce a scalable secure Cloud database abstraction layer combined with sophisticated distribution and encryption methods into the processing and querying of data stored in the Cloud; (b) context-aware access control that incorporate the dynamically changing contextual information into novel group policies implementing configurable context-based access control policies and context-dependent access rights to the stored data at various different levels; and (c) policy governance, modelling and annotation techniques that allows application developers to specify an appropriate level of protection for the applications data, while the evaluation of whether an incoming request should be granted access to the target data takes dynamically place during application runtime.";4461513;3984575;H2020-ICT-2014-1;RIA;CAS SOFTWARE AG;DE;"INTRASOFT INTERNATIONAL SA;SIEMENS SRL;SIXSQ SARL;SINGULARLOGIC CYPRUS LTD;GIOUMPITEK MELETI SCHEDIASMOS YLOPOIISI KAI POLISI ERGON PLIROFORIKIS ETAIREIA PERIORISMENIS EFTHYNIS;KARLSRUHER INSTITUT FUER TECHNOLOGIE;RISE SICS AB;KENTRO EREVNON NOTIOANATOLIKIS EVROPIS ASTIKI MI KERDOSKOPIKI ETAIREIA;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS";"LU;RO;CH;CY;EL;DE;SE"; 194385;645759;WASTCArD;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Wrist and arm sensing technologies for cardiac arrhythmias detection;1/05/2015;30/04/2018;;"Abnormal heart rhythms are a major cause of cardiovascular disease and death in Europe. Sudden cardiac death accounts for 50% of cardiac mortality in developed countries; ventricular tachycardia or ventricular fibrillation is the commonest underlying arrhythmia. In the ambulatory population, atrial fibrillation is the commonest one, and is associated with increased risk of stroke and heart failure, particularly in the aged population. If arrhythmias are detected at an early stage of heart disease, appropriate treatment can be effective, reducing disability and death. However, in the early stages of disease these may be transient, lasting only a few seconds, and thus difficult to detect. Current approaches to cardiac rhythm monitoring include: a) non-invasive external recording devices; which are suitable for short term (<24h) recording, and b) implantable loop recorders, which are inserted subcutaneously beneath the chest wall; capable of monitoring heart rhythm for extended periods, but there is considerable expense associated with the device, hospitalisation costs and risk of infection.

The proposed joint research project through staff exchange activities, will investigate enabling technologies for non-invasive recording heart rhythm during long periods of time (>36h), using a wrist or arm wearable device with novel ECG sensing techniques and embedded real-time cardiac arrhythmia detection processes. The problem of extracting the far-field heart electrogram signal from noise components will be addressed using smart denoising algorithms.

The project will impact by establishing a successful international and intersectoral partnership for the development of new technologies addressing a significant cardiovascular healthcare problem. These technologies will be suitable for integration into current e-Health and cardiac information systems, and will impact on healthcare costs reduction by improved efficiency in the diagnosis and early treatment of cardiac disease.";324000;324000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITY OF ULSTER;UK;"Southern Health and Social Care Trust;WATERFORD INSTITUTE OF TECHNOLOGY;INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON;S.D. INFORMATIKA DOO INFORMATICKI INZENJERING, POSLOVNE USLUGE I TRGOVINA;SVEUCILISTE U ZAGREBU FAKULTET ELEKTROTEHNIKE I RACUNARSTVA;INTELESENS LTD";"UK;IE;FR;HR"; 194357;645674;PROCROP;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Harnessing Plant Reproduction for Crop Improvement;1/02/2015;31/01/2019;;Increased crop productivity through genetic improvement of plants has significantly impacted world agriculture and the worlds population. Crop plants have followed the general pattern of introduction, selection, and hybridization. Once introgressed, selection and breeding strategies have led to new cultivars with improved yield and adaptation. Unfortunately, many of these important traits are typically polygenic. The consequence is that only certain unique allele combinations comply to generate elite performing genotypes. The fixation of a given genotype occurs naturally in species that display an asexual type of seed production named apomixis (i.e. clonal seed production). Unfortunately, apomixis does not naturally occur in major crop species with few exceptions (Citrus, mango and mangosteen). In crop species, apomixis would enable the instantaneous fixation of the complete genome of the best plants. When coupled with male-sterility systems, apomictic reproduction (with no need for male contribution) could help in addressing issues related to transgene escape from GM crops to organic or conventional crops, and thereby allow for better coexistence systems. This trait by itself is highly valuable for agriculture, but despite many efforts it has never been possible to introduce it into the domesticated crop species of today. The financial and economic impacts of the development of apomixis technology and its application to major crops are amazing (1800-2300 million per annum per crop). The overall goal of the proposal is to allow for a synergy of inter-related European and international expertise to better understand the mechanisms of sexual/apomictic plant reproduction and to facilitate the application of this increased knowledge in the development of new approaches for agriculture and food industry to increase productivity.;738000;738000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DEGLI STUDI DI PERUGIA;IT;"UNIVERSITA DEGLI STUDI DI MILANO;POLO D' INNOVAZIONE DI GENOMICA, GENETICA E BIOLOGIA SCARL;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT";"IT;FR"; 194294;645215;No One Left Behind;SIGNED;H2020-EU.2.1.1.4.;ICT-21-2014;H2020;No One Left Behind;1/01/2015;30/06/2017;;"As stated in Forbes, .. the world of education is going to go through one of the most massive changes in the next five years than it has seen in the last three thousand years. Its a perfect storm. This change is driven by the extreme pressure on schools to produce outcomes, too many children are leaving school with no meaningful job skills; and those children at risk of exclusion are especially affected as they are not able to reach their full potential. In parallel, the business growth potential for non-leisure applications of digital games is wide, and estimated to reach 77 billion in 2015.

No One Left Behind has been created to take advantages of the opportunities and the potential of digital games to tackle these challenges in the education sector.

This project will create a new generation of Pocket Code (a mobile media-rich programming environment for children) to unlock inclusive gaming creation and experiences in formal learning situations, underpin meaningful learning and support children to realise their full potential; by transferring game mechanics, dynamics, assets and in-game analytics from non-leisure digital games SMEs, into Pocket Code, which also will be adapted to academic curricula.

Evidence of this approach will be provided through 3 experimental pilots (UK, Austria and Spain) comprising some 600 children/students, over 9-12 academic subjects and in 5 schools. A realistic business model and plan for No One Left Behinds exploitable outputs is provided in order to support the project`s sustainability and scalability. Furthermore, impact arising from the project will be enabled by the effective cross-sectoral technology transfer (from leisure to non-leisure sectors). This will include new products and services, and through the scaling of current SMEs game-based products for the educational sector, and by improving backend analytics that can be monetized through freemium business models and segmented advertising.";3173812,5;2687925;H2020-ICT-2014-1;IA;INMARK EUROPA SA;ES;"TECHNISCHE UNIVERSITAET GRAZ;GAMECITY LTD;HOCHSCHULE DER MEDIEN;THE NOTTINGHAM TRENT UNIVERSITY;UNIVERSIDAD POLITECNICA DE MADRID;ZED WORLDWIDE S.A.";"AT;UK;DE;ES"; 194304;645274;WiSHFUL;SIGNED;H2020-EU.2.1.1.3.;ICT-11-2014;H2020;Wireless Software and Hardware platforms for Flexible and Unified radio and network controL;1/01/2015;31/12/2017;;"Wireless testbeds have become an essential tool to develop and validate innovative wireless solutions. However, due to the increasing diversity of wireless solutions and competing radio technologies, along with the ever more stringent requirements on the reliability of test results, wireless test facilities have evolved to very complex systems with steep learning curves for innovators. To speed up and facilitate the experimentation process, to lower its cost and to enhance the uptake of future non- and pre-standard solutions, the WiSHFUL project is determined to lower the experimentation threshold by developing flexible, scalable, open software architectures and programming interfaces for prototyping novel wireless solutions for a variety of applications ranging from healthcare to smart cities, supporting players in high value-add markets with considerable growth potential.
Key features of WiSHFUL include (1) unified radio control, providing developers with deep control of physical and medium access components without requiring deep knowledge of the radio hardware platform and (2) unified network control allowing the rapid creation, modification, and prototyping of protocols across the entire stack.
WiSHFUL will also create a testbed-on-the-move, consisting of portable facilities that can be deployed easily and efficiently at any location, allowing validation of innovative wireless solutions in the real world (with realistic propagation and interference characteristics) and involving real users. The usefulness of these facilities will be confirmed by participation of industrial and academic partners through open calls for experimentation.
In addition, we envision to extend these facilities with the capability to experiment with emerging wireless technologies such as millimeter wave communications, full-duplex and massive MIMO in the scope of open calls for extensions.";5491752,25;5171000;H2020-ICT-2014-1;RIA;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;BE;"CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;NCENTRIC EUROPE BVBA;TECHNISCHE UNIVERSITAET BERLIN;UNIVERSIDADE FEDERAL DO RIO DE JANEIRO;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY;SEOUL NATIONAL UNIVERSITY";"IT;IE;BE;DE;BR;US;KR"; 194206;644424;STARTIFY7;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;A TEAM-BUILDING, THEMATICALLY-FOCUSED AND LEAN-TRAINING SUMMER ACADEMY SYSTEM FOR YOUNG FUTURE ICT ENTREPRENEURS;1/01/2015;31/12/2016;;"An innovative training structure focused on addressing the limited capability of young European ICT future entrepreneurs is needed. This is a challenging task, since existing European ICT entrepreneurship training initiatives are characterised by a general fragmentation and a lack of a learning-by-doing training approach. STARTIFY7 is an innovative and ambitious project aiming to go beyond the state-of-the-art and create strong synergies with existing initiatives and projects. It suggests a unique approach to ICT entrepreneurial education for the youth, with the following objectives: 1) Perform a thorough Training Needs Analysis for the future ICT entrepreneurs. 2) Embed a team-building process within a lean-training structure. 3) Establish an effective network of trainers. 4) Create innovative lean-training curricula with thematic ICT focus. 5) Ignite competition and strong synergies with existing initiatives. 6) Disseminate, exploit and ensure long-term sustainability.
The innovative outcomes of the project are the following: 1) Seven Summer Academies in 7 different European cities within a timeframe of two sequential summers (i.e. 2015 and 2016). 2) Seven lean-training and thematically-focused training curricula, embedding a strong team-building process. 3) An integrated network of trainers focused on hands-on and real-world knowledge transfer. 4) A competition based on the best performing teams after the completion of each round of summer academies. 5) Complement, extend and enrich similar existing actions. 6) A centralized social networking service. 7) ECTS credits provision. 8) An integrated exploitation and sustainability plan with the aim of making STARTIFY7 a long-term viable Summer Academy.
STARTIFY7 will aim for 1.400 applications from potential entrepreneurs, 280 student participants, 90 produced demos, 70 engaged teachers/coaches/mentors, 2 boot-camps with 63 participants, 10 VC/angels investors engaged, and, 16 investment-ready proposals.";1423165;1330277,12;H2020-ICT-2014-1;IA;THE UNIVERSITY OF SHEFFIELD;UK;"UNIVERSIDAD DE ALMERIA;Friedrich-Alexander University (FAU) Erlangen-Nrnberg;EUROPE UNLIMITED S.A.;ASSOCIAZIONE TRENTO RISE;UNIVERSITEIT TWENTE;HUB INNOVAZIONE TRENTINO S.C.A.R.L.;INCUBATION FOR GROWTH AE;UNIWERSYTET EKONOMICZNY W KATOWICACH;KENTRO EREVNON NOTIOANATOLIKIS EVROPIS ASTIKI MI KERDOSKOPIKI ETAIREIA;EUROPEAN CONFEDERATION OF YOUNG ENTREPRENEURS AISBL;UNTERNEHMERTUM GMBH";"ES;DE;BE;IT;NL;EL;PL"; 194478;646984;3D-LEAP;SIGNED;"H2020-EU.2.3.1.;H2020-EU.2.1.1.";ICT-37-2014-1;H2020;3 Dimensional Light Sensor for Advanced Portable Devices;1/10/2014;31/12/2014;;"This proposal aims to develop miniaturized 3 Dimensional (3D) cameras for mobile phones, tablets and laptop computers; more specifically embedded camera modules providing 2D and 3D-Images, integrating image-sensing electronics and light-field optics in a single lens Wafer Level Camera (WLC).
This disruptive device is aiming towards significant market-shares and global leadership in 3D-imaging camera modules, accelerating our growth and Europes Competitive position in Smart Cameras for 3D-imaging. We introduce a paradigm changer in one of the highest growth areas addressable in consumer technologies, setting entry barriers difficult to overcome for current and new market players; we will hit the market while established competitors will still be trying to figure out our algorithms, our IPR and our hardware solution.
Our most disruptive competitive advantage is based on our algorithms, exploiting a novel hardware structure.
First contacts with Taiwanese distributors and manufacturers of laptop/network/tablet computers and mobile phones allow us to think that such a disruptive device can sell millions of units.
This phase-1 study will minimize technical and market acceptance risks. We extend the well-known FSV-model to FSOV (Fabless Semiconductor and Optical Vendor). Manufacturing, both for the semiconductor image sensors and for the optical layers on top of it, will be performed by third parties (silicon foundries and optical foundries). One of the main tasks of this feasibility study is to choose the best manufacturing partners from the handful of candidate companies in both sectors (silicon and optics), as well as obtaining exact quotations for the costs of the BOM (Bill of Materials); we will also visit some potential customers to verify correctness of the data (sales volumes and price targets) and build a Business Plan that will include Product Roadmap, Project Plan and Marketing and Sales Plans.";71429;50000;H2020-SMEINST-1-2014;SME-1;PHOTONIC SENSORS AND ALGORITHMS SL;ES;;; 194453;646533;BIOSURF;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.3.1.;H2020-EU.3.3.2.";LCE-14-2014;H2020;BIOmethane as SUstainable and Renewable Fuel;1/01/2015;31/12/2017;;"The objective of BIOSURF (BIOmethane as SUstainable and Renewable Fuel) is to increase the production and use of biomethane (from animal waste, other waste materials and sustainable biomass), for grid injection and as transport fuel, by removing non-technical barriers and by paving the way towards a European biomethane market.
This objective will be achieved through the following founding pillars:
- National biomethane registries
- Cooperation among the national biomethane registries
- European mass-balancing system for biomethane
- Free Market Biomethane Trade
- Sustainable raw material supply
- Methodology for entitlement to CO2 certificates
- Regional specificities
- Networking and Cooperation
- Transferability of results beyond the projects countries.
BIOSURF relates, within the Work Program 2014-2015 on Secure, clean and efficient energy, to the Call COMPETITIVE LOW-CARBON ENERGY, namely the topic LCE 14 2014/2015: Market uptake of existing and emerging sustainable bioenergy.
The qualifying ideas of BIOSURF are:
To develop a value chain analysis from production to use depending on the territorial, physical and economic features (specified for different areas, i.e., biofuel for transport, electricity generation, heating & cooling);
To analyse, compare and promote biomethane registering, labelling, certification and trade practices in Europe, in order to favour cooperation among the different countries and cross border markets on the basis of the partner countries involved;
To address traceability, environmental criteria and quality standards, so aiming to reduce GHG emissions and indirect land-use change (ILUC), to preserve biodiversity and to assess the energy and CO2 balance; to identify the most prominent drivers for CO2-emissions along the value chain as an input for future optimization approaches;
To exchange information and best practices all along Europe concerning biomethane policy, regulations, support schemes and technical standards.";1872912,13;1872912,13;H2020-LCE-2014-3;CSA;ISTITUTO DI STUDI PER L'INTEGRAZIONE DEI SISTEMI (I.S.I.S) - SOCIETA'COOPERATIVA;IT;"CIB-CONSORZIO ITALIANO BIOGAS E GASSIFICAZIONE;MAGYAR BIOGAZ EGYESULET;GROUPEMENT REGIONAL DES CENTRES D ETUDES TECHNIQUES AGRICOLES DE L ILE DE FRANCE GRCETA;FACHVERBAND BIOGAS EV;AGCS GAS CLEARING AND SETTLEMENT AG;Fachagentur Nachwachsende Rohstoffe e.V.;ARGE KOMPOST UND BIOGAS OSTERREICH VEREIN;ASSOCIAT TECHNIQUE ENERGIE ENVIRONNEMENT;DBFZ DEUTSCHES BIOMASSEFORSCHUNGSZENTRUM GEMEINNUETZIGE GMBH;RENEWABLE ENERGY ASSOCIATION LBG;EUROPEAN BIOGAS ASSOCIATION";"IT;HU;FR;DE;AT;UK;BE"; 194231;644669;POSEIDON;SIGNED;H2020-EU.2.1.1.6.;ICT-26-2014;H2020;Plasmonic-based autOmated lab-on-chip SEnsor for the rapid In-situ Detection of LegiONella;1/01/2015;31/12/2017;;Legionnaires disease is a serious form of pneumonia caused by bacterium Legionella pneumophila, with a case-fatality ratio on the order of 10-15%. L. pneumophila proliferates in aquatic habitats, especially in potable water, air conditioning, hot and cold water systems, cooling towers, evaporative condensers, spa/natural pools. Actually, its detection and monitoring rely on time-consuming protocols (in the order of several days) based on in-vitro selective bacteria culture methods, performed by highly specialized personnel in dedicated laboratories. POSEIDON project targets to change the approach in bacteriological environmental monitoring and in infection risk management by developing a fully automatic and reliable system. Handling of the air/water sample will be designed and integrated in preconditioning system and microfluidic device through which whole bacteria cells will be transported from the sampling module to the sensing plasmonic surface. The complete measure protocol will be integrated and performed according to EU legislation guidelines. Specificity will be ensured by immuno-functionalization of gratings surfaces and enhanced system sensitivity will be granted by the optimization of the optical detection system architecture. Sensors based on Grating Coupled Surface Plasmon Resonance (GC-SPR) in azimuthally rotating configuration have recently proved sensitivity enhancement up to almost two orders of magnitude. Furthermore, the symmetry breaking related to grating rotation allows exploiting the incident polarization, more easily controlled with respect to incidence wavelength and angles interrogation. The prototype will be designed to be integrated in water distribution or HVAC systems in order to demonstrate its feasibility in industrially relevant fields and to open new applications and new market opportunities. POSEIDON project aims to address new solutions in this relevant health and safety societal challenge.;4068781;4068781;H2020-ICT-2014-1;RIA;CLIVET SPA;IT;"METROHM-APPLIKON;Uppsala universitet;VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI;CATLAB-CENTRE ANALITIQUES TERRASSA AIE;ARC - CENTRO RICERCHE APPLICATE;PROTOLAB SRL";"NL;SE;IT;ES"; 194240;644729;SAFEcrypto;SIGNED;H2020-EU.2.1.1.;ICT-32-2014;H2020;Secure Architectures of Future Emerging Cryptography;1/01/2015;31/12/2018;;"SAFEcrypto will provide a new generation of practical, robust and physically secure post quantum cryptographic solutions that ensure long-term security for future ICT systems, services and applications. Novel public-key cryptographic schemes (digital signatures, authentication, public-key encryption, identity-based encryption) will be developed using lattice problems as the source of computational hardness.

The project will involve algorithmic and design optimisations, and implementations of the lattice-based cryptographic schemes addressing the cost, energy consumption, performance and physical robustness needs of resource-constrained applications, such as mobile, battery-operated devices, and of real-time applications such as network security, satellite communications and cloud.

Currently a significant threat to cryptographic applications is that the devices on which they are implemented on leak information, which can be used to mount attacks to recover secret information. In SAFEcrypto the first analysis and development of physical-attack resistant methodologies for lattice-based cryptographic implementations will be undertaken.

Effective models for the management, storage and distribution of the keys utilised in the proposed schemes (key sizes may be in the order of kilobytes or megabytes) will also be provided.

This project will deliver proof-of-concept demonstrators of the novel lattice-based public-key cryptographic schemes for three practical real-word case studies with real-time performance and low power consumption requirements. In comparison to current state-of-the-art implementations of conventional public-key cryptosystems (RSA and Elliptic Curve Cryptography (ECC)), SAFEcryptos objective is to achieve a range of lattice-based architectures that provide comparable area costs, a 10-fold speed-up in throughput for real-time application scenarios, and a 5-fold reduction in energy consumption for low-power and embedded and mobile applications.";4081827,25;3266927,25;H2020-ICT-2014-1;RIA;THE QUEEN'S UNIVERSITY OF BELFAST;UK;"THALES UK LIMITED;H W COMMUNICATIONS LIMITED;IBM RESEARCH GMBH;EMC INFORMATION SYSTEMS INTERNATIONAL;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;UNIVERSITA DELLA SVIZZERA ITALIANA;RUHR-UNIVERSITAET BOCHUM";"UK;CH;IE;FR;DE"; 194151;644096;ECOMODE;SIGNED;H2020-EU.2.1.1.4.;ICT-22-2014;H2020;Event-Driven Compressive Vision for Multimodal Interaction with Mobile Devices;1/01/2015;31/12/2018;;"The visually impaired and the elderly, often suffering from mild speech and/or motor disabilities, are experiencing a significant and increasing barrier in accessing ICT technology and services. Yet, in order to be able to participate in a modern, interconnected society that relies on ICT technologies for handling everyday issues, there is clear need also for these user groups to have access to ICT, in particular to mobile platforms such as tablet computers or smart-phones.
The proposed project aims at developing and exploiting the recently matured and quickly advancing biologically-inspired technology of event-driven, compressive sensing (EDC) of audio-visual information, to realize a new generation of low-power multi-modal human-computer interface for mobile devices.
The project is based on two main technology pillars: (A) an air gesture control set, and (B) a vision-assisted speech recognition set. (A) exploits EDC vision for low and high level hand and finger gesture recognition and subsequent command execution; (B) combines temporal dynamics from lip and chin motion acquired using EDC vision sensors with the auditory sensor input to gain robustness and background noise immunity of spoken command recognition and speech-to-text input.
In contrast to state-of-the-art technologies, both proposed human-computer communication channels will be designed to work reliably under uncontrolled conditions. Particularly, mobile devices equipped with the proposed interface technology will facilitate unrestricted outdoor use under uncontrolled lighting and background noise conditions. Furthermore, due to the sparse nature of information encoding, EDC excels conventional approaches in energy efficiency, yielding an ideal solution for mobile, battery-powered devices.
ECOMODE is committed to pave the way for industrialization of commercial products by demonstrating the availability of the required hardware and software components and their integrability into a mobile platform.";3798206,5;3798206,5;H2020-ICT-2014-1;RIA;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;FR;"FONDATION DE COOPERATION SCIENTIFIQUE VOIR ET ENTENDRE;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;Streetlab;INNOVATI NETWORKS SL;CHRONOCAM SAS;FONDAZIONE BRUNO KESSLER";"FR;ES;IT"; 194164;644184;CPS Summit;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Transatlantic CPS Summit;1/02/2015;31/07/2016;;"Cyber-physical systems (CPS) are a core enabling technology for securing economic leadership in embedded systems and ICT, having an enormous social and economic importance, and making decisive contributions to societal challenges. The EU and the US face common challenges to push forward the limits of the science for engineering CPS, creating a favorable environment for strategic and pre-competitive collaboration.

The Transatlantic CPS Summit is an ambitious 18-month support action with the goal of facilitating and creating an enduring and sustainable collaboration campaign on CPS research and development between Europe and the US. The support action achieves its overall aim by means of:
1. Identifying and evaluating possible R&D cooperations between Europe and the US;
2. Investigating and promoting implementation of opportunities for cooperation;
3. Preparing a roadmap for R&D cooperation on CPS engineering between the EU and US together with recommendations for action;
4. Presenting final results to interested stakeholders (e.g. public bodies, industry, academic researchers) on both sides of the Atlantic.

To achieve the above, the project mobilises an outstanding multidisciplinary consortium of 7 EU partners and 5 US partners and brings together recognized CPS researchers across the EU and the US in a series of CPS Summit Workshops.";181250;181250;H2020-ICT-2014-1;CSA;FORTISS GMBH;DE;"TECHNISCHE UNIVERSITAET WIEN;AALBORG UNIVERSITET;OFFIS EV;UNIVERSITE JOSEPH FOURIER GRENOBLE 1;UNIVERSITE GRENOBLE ALPES";"AT;DK;DE;FR"; 194185;644298;HyVar;SIGNED;H2020-EU.2.1.1.3.;ICT-09-2014;H2020;Scalable Hybrid Variability for Distributed Evolving Software Systems;1/02/2015;31/01/2018;;"HyVar proposes a development framework for continuous and individualized evolution of distributed software applications running on remote devices in heterogeneous environments. The framework will combine variability modeling from software product lines with formal methods and software upgrades, and be integrated in existing software development processes. HyVar's objectives are (O1) to develop a Domain Specific Variability Language (DSVL) and tool chain to support software variability for such applications; (O2) to develop a cloud infrastructure that exploits software variability as described in the DSVL to track the software configurations deployed on remote devices and to enable (i) the collection of data from the devices to monitor their behavior; and (ii) secure and efficient customized updates; (O3) to develop a technology for over-the-air updates of distributed applications which enables continuous software evolution after deployment on complex remote devices that incorporate a system of systems; and (O4) to test HyVar's approach as described in the above objectives in an industry-led demonstrator to assess in quantifiable ways its benefits. HyVar goes beyond the state-of-the-art by proposing hybrid variability; i.e., the automatic generation and deployment of software updates combines the variability model describing possible software configurations with sensor data collected from the device. HyVar's scalable cloud infrastructure will elastically support monitoring and customization for numerous application instances. Software analysis will exploit the structure of the variability models. Upgrades will be seamless and sufficiently nonintrusive to enhance the user quality experience, without compromising the robustness, reliability and resilience of the distributed application instances. To maximize impact and innovation, the consortium balances carefully selected academic and industrial partners ensuring both technology pull and push.";2793870;2793870;H2020-ICT-2014-1;RIA;SANTER REPLY SPA;IT;"UNIVERSITETET I OSLO;ATBROX AS;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;UNIVERSITA DEGLI STUDI DI TORINO;MAGNETI MARELLI S.P.A.";"NO;DE;IT"; 194370;645710;ICI-THROUGH;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Intersectoral collaboration for innovation in non-invasive techniques to estimate human brown adipose tissue activity;1/12/2014;30/11/2018;;Non-invasive, inexpensive, and accurate assessment of adipose tissue (BAT) activity is crucial in the fight against metabolic pandemics such as obesity, and in various industries (e.g., foods, pharmaceuticals). However, the only technique available to measure the activity of this tissue is PET/CT imaging of the glucosetracer 18F-fluorodeoxyglucose, a highly invasive technique that is harmful for human health, expensive, and requires extensive equipment and facilities. The development and validation of non-invasive and practical techniques to accurately estimate human BAT activity requires the creation of new technology and the advancement of the current state of the art. Companies (particularly SMEs) do not have the technical capabilities to conduct R&D activities at the level of excellence required for such development. Academic institutions have the capacity to conduct the necessary R&D but they lack the expertise to develop the prototype post project. To solve this intersectoral problem, the ICI-THROUGH project will create a sustainable innovation platform of intersectoral collaboration between two academic (UOT and UOP) and two industrial (IMED and CETRI) European participants to exchange knowledge on the development of non-invasive techniques to estimate human BAT activity. This will be achieved via a series of clear and measurable research and innovation objectives that will be realized via staff exchanges of experienced and early-stage researchers divided into: networking, research and training, workshop, innovation, dissemination, and public engagement activities. The ICI-THROUGH project is effectively aligned with the scope of the RISE call and its success is in the interest of all participants. Also, exploitation of the obtained tangible outcomes (e.g., prototype) will ensure the partnerships sustainability post project. Thus, the ICI-THROUGH project has high potential to become a self-sustaining innovation incubator between the four participants.;828000;828000;H2020-MSCA-RISE-2014;MSCA-RISE;PANEPISTIMIO THESSALIAS;EL;"IMEDICA SA;CENTER FOR TECHNOLOGY RESEARCH AND INNOVATION LTD;UNIVERSIDADE DO PORTO";"RO;CY;PT"; 194279;645096;AppHub;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;AppHub, the European Open Source Marketplace;1/01/2015;31/12/2016;;"Many software engineering and cloud computing are developed in open source in order to implicitly avoid the curse of the European science paradox -- we are good at science but poor at exploitation but fail because they lack adequate support and strategy. Open source provides an efficient framework for cooperation and IP management and that makes it indeed a powerful enabler for collaborative innovation. It is wrong however to assume that making the source available automatically attracts contributors and grants immediate market access. Open source as a convenient process is not the same as open source as a business strategy.
The aim of this project is to support the market outreach strategies of EU-supported open source by launching AppHub, the European open source market place. AppHub is a service platform that will help the market to seamlessly identify, position and implement the software outcomes of these projects. The partners that will develop, run and promote AppHub over this two-year project and beyond combine unparalleled expertise in open source community management, EU research projects and a breakthrough technology in software asset management.";849260;849260;H2020-ICT-2014-1;CSA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"OW2 CONSORTIUM ASSOCIATION;USHARESOFT";FR; 194232;644672;INPUT;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;In-Network Programmability for next-generation personal cloUd service supporT;1/01/2015;31/12/2017;;"The INPUT Project aims at designing a novel infrastructure and paradigm to support Future Internet personal cloud services in a more scalable and sustainable way and with innovative added-value capabilities. The INPUT technologies will enable next-generation cloud applications to go beyond classical service models, and even to replace physical Smart Devices, usually placed in users homes (e.g., set-top-boxes, etc.) or deployed around for monitoring purposes (e.g., sensors), with their virtual images, providing them to users as a Service. Virtual and physical SDs will be made available to users at any time and at any place by means of virtual cloud-powered Personal Networks, which will constitute an underlying service model. These Personal Networks will provide users the perception to be always in their home LAN with their own smart digital (virtual and physical) devices.
The INPUT project will overcome current limitations in the cloud service design due to the underlying obsolete network paradigms and technologies, by:
using the computing and storage capabilities of network appliances to allow users create private clouds in the network;
exploiting the energy consumed in network appliances more efficiently than in traditional cloud computing scenarios;
moving cloud services much closer to end-users and smart-devices, thus avoiding useless network infrastructure overloading;
The INPUT Project will foster future-proof Internet infrastructures that will be smarter, fully virtualized, power vs. performance optimised, and vertically integrated with cloud computing, with a clear impact on OPEX and CAPEX of Telecoms, of Service Providers, and of end-users. The INPUT project will extend the programmability of network devices to make them able to host cloud service applications, which will cooperate with the ones in users terminals and datacenters to realize the aforementioned cloud services.";3108001;3108001;H2020-ICT-2014-1;RIA;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;IT;"ERICSSON TELECOMUNICAZIONI;DUBLIN CITY UNIVERSITY;COSMOTE KINITES TILEPIKOINONIES AE;TELECOM ITALIA SPA;INFOCOM S.R.L.;GIOUMPITEK MELETI SCHEDIASMOS YLOPOIISI KAI POLISI ERGON PLIROFORIKIS ETAIREIA PERIORISMENIS EFTHYNIS;JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG;HOP UBIQUITOUS SL";"IT;IE;EL;DE;ES"; 194463;646644;bi-BLOCK;SIGNED;H2020-EU.1.1.;ERC-CoG-2014;H2020;Building and bypassing plant polyspermy blocks;1/09/2015;31/08/2020;;The ultimate goal for the survival of all species on earth is to reproduce. This uncompromising principle has triggered the evolution of numerous adaptations. One strategy commonly employed by sexually reproducing eukaryotes is the production of tremendous amounts of sperm to maximize the likelihood of an egg becoming fertilised. High sperm to egg ratios are, however, associated with an increased risk of supernumerary sperm fusion. This so-called polyspermy is lethal in many organisms. Accordingly, eukaryotes have evolved polyspermy barriers, which are implemented at different levels in the reproductive process. Flowering plants tightly control the number of sperm-transporting pollen tubes approaching a single ovule by a so-called pollen tube block. We have recently shown that the pollen tube block is relaxed in ethylene hyposensitive plants. Capitalizing on these results, this project aims at identifying and characterising the molecular mechanisms underlying plant polyspermy barriers.;1910769;1910769;ERC-2014-CoG;ERC-COG;UNIVERSITAET BREMEN;DE;;; 194191;644332;OpenAIS;SIGNED;H2020-EU.2.1.1.6.;ICT-26-2014;H2020;Open Architectures for Intelligent Solid State Lighting Systems;1/01/2015;31/12/2017;;"Following the trends of the creation of the The Internet of Things (IoT) and the rapid penetration of SSL based lighting, it is very advantageous to connect the luminaires in buildings to the Internet.
OpenAIS aims at setting the leading standard for inclusion of lighting for professional applications in to IoT, with a focus on office lighting. This will enable a transition from the currently existing closed and command oriented lighting control systems to an open and service oriented system architecture. Openness and service orientation will create an eco-system of suppliers of interoperable components and a market for apps that exploit the lighting system to add value beyond the lighting function. Added value can e.g. be related to more efficient use of the building, reduction of carbon footprint and increased comfort and wellbeing. In addition, IoT will facilitate smooth and effective interaction of the lighting system with other functions in a building such as e.g. HVAC, security and access control. Extensibility and security of the system architecture are important aspects and will be guaranteed.
The OpenAIS project will define the requirements and use cases for offices in 2020, define the best open system architecture, identify existing ICT components to be used and develop additional components. The system will be validated by a pilot installation in a real office setting. After the OpenAIS project, the Consortium will pursue standardization of the system architecture, aiming at the creation of the leading standard for Internet connected lighting.
The project brings together a strong collaboration of the leading lighting companies Zumtobel, Tridonic, and Philips and the major players in IoT technology ARM, NXP and Imtech. Consortium partner Johnson Controls represents the end user and academic knowledge on ICT and system architecture is present through TU/e and TNO-ESI. During the project, the Consortium will seek close cooperation with the IoT community.";10775371,25;7893553;H2020-ICT-2014-1;IA;PHILIPS LIGHTING B.V.;NL;"ARM LIMITED;IMTECH TELECOM;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;JOHNSON CONTROLS SYSTEMS AND SERVICE ITALY SRL;TRIDONIC GMBH & CO KG;NXP SEMICONDUCTORS NETHERLANDS BV;TECHNISCHE UNIVERSITEIT EINDHOVEN;PHILIPS ELECTRONICS NEDERLAND B.V.;ZUMTOBEL LIGHTING GMBH";"UK;BE;NL;IT;AT"; 194248;644821;TAMS4CPS;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Trans-Atlantic Modelling and Simulation For Cyber-Physical Systems;1/02/2015;31/01/2017;;"Smart systems, in which sophisticated software/hardware is embedded in physical systems are part of everyday life. From simple products with embedded decision making software to massive systems in which hundreds of systems, each with hundreds or thousands of embedded processors, interoperate, the growth of cyber-physical systems (CPS) is likely to accelerate. For Europe to benefit from this expansion, while avoiding the pitfalls that such complexity creates, there must be advances in the modelling and simulation (M&S) of CPS. Collaborative research with the US will be an opportunity to advance European M&S capabilities for CPS. The overall aim of TAMS4CPS is to lay the foundations for concrete EU-US collaboration in modelling and simulation for cyber-physical systems. To achieve this, Loughborough and Newcastle Universities (M&S) will work with Steinbeis Innovation (road mapping) and leading researchers in the field at top US universities to create:
- A strategic research and collaboration agenda, endorsed by researchers in EU and US
- A set of test cases for model developers to perform collaborative evaluation
- A state of the art web-based report to act as a baseline for collaborative research
Taking a consultative approach, we will engage industry and academic researchers and M&S users in workshops and web-based meetings to prioritise M&S research challenges and to create a constituency of future collaboration partners for pre-competitive research in the Artemis themes, of:
- Architectures principles and models for safe secure Cyber-Physical Systems
- Systems design, modelling and virtual engineering for Cyber-Physical Systems
- Autonomous adaptive and cooperative of Cyber-Physical Systems
- Computing platforms and energy management for Cyber-Physical Systems
To which is added the exploitation and enabling theme of:
- Integration of socio/legal/governance models within modelling frameworks
Thus, this project directly addresses European priorities in CPS.";399650;399649,75;H2020-ICT-2014-1;CSA;LOUGHBOROUGH UNIVERSITY;UK;"UNIVERSITY OF NEWCASTLE UPON TYNE;STEINBEIS 2I GMBH;STEINBEIS INNOVATION GGMBH";"UK;DE"; 194264;644956;RAIS;SIGNED;H2020-EU.2.1.1.6.;ICT-26-2014;H2020;Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis;1/01/2015;31/12/2017;;"The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than 10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.";3388572,5;2988572,5;H2020-ICT-2014-1;RIA;FUNDACIO INSTITUT DE CIENCIES FOTONIQUES;ES;"BRAHMS GMBH;DIESSE DIAGNOSTICA SENESE SPA;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;IXSCIENT LIMITED;ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;INSTITUT CATALA DE LA SALUT;microTEC Gesellschaft fuer Mikrotechnologie mbH;TRINEAN NV";"DE;IT;ES;UK;CH;BE"; 194149;644080;SAFURE;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;SAFety and secURity by design for interconnected mixed-critical cyber-physical systems;1/02/2015;31/01/2018;;"'SAFURE targets the design of cyber-physical systems by implementing a methodology that ensures safety and security 'by construction'. This methodology is enabled by a framework developed to extend system capabilities so as to control the concurrent effects of security threats on the system behaviour.
The current approach for security on safety-critical embedded systems is generally to keep subsystems separated, but this approach is now being challenged by technological evolution towards openness, increased communications and use of multi-core architectures.
The objectives of SAFURE are to (1) implement a holistic approach to safety and security of embedded dependable systems, preventing and detecting potential attacks; (2) to empower designers and developers with analysis methods, development tools and execution capabilities that jointly consider security and safety; (3) to set the ground for the development of SAFURE-compliant mixed-critical embedded products.
The results of SAFURE will be (1) a framework with the capability to detect, prevent and protect from security threats on safety, able to monitor from application level down to the hardware level potential attacks to system integrity from time, energy, temperature and data threats; (2) a methodology that supports the joint design of safety and security of embedded systems, assisting the designer and developers with tools and modelling languages extensions; (3) proof-of concept through 3 industrial use cases in automotive and telecommunications; (4) recommendations for extensions of standards to integrate security on safety-critical systems; (5) specifications to design and develop SAFURE-compliant products.
The impact of SAFURE will help European suppliers of safety-critical embedded products to develop more cost and energy-aware solutions. To ensure this impact, a community will be created around the project. SAFURE comprises 7 industrial manufacturers, 4 leading universities and research centres and 1 SME.'";5702631,25;5231375;H2020-ICT-2014-1;RIA;TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH;AT;"THALES COMMUNICATIONS & SECURITY SAS;SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;SYMTAVISION GMBH;BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;SYSGO AG;EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH;TTTECH COMPUTERTECHNIK AG;ESCRYPT GMBH EMBEDDED SECURITY;THALES SA;MAGNETI MARELLI S.P.A.";"FR;IT;DE;ES;CH;AT"; 194170;644204;ProsocialLearn;SIGNED;H2020-EU.2.1.1.4.;ICT-21-2014;H2020;ProsocialLearn - Gamification of Prosocial Learning for Increased Youth Inclusion and Academic Achievement;1/01/2015;31/12/2017;;ProsocialLearn will establish a new market for digital games aiming at increasing social inclusion and academic performance. A ground-breaking digital gaming genre will be created that focuses on helping children to acquire prosocial skills necessary for positive relationships, team working, trustworthiness and emotional intelligence. ProsocialLearn will deliver a series of disruptive innovations building on a game development and distribution platform for the production of prosocial games that engages children and stimulates technology transfer from traditional game industry to the education sector. ProsocialLearn will offer games developers scientifically proven prosocial game elements for development digital games. An application programming interface (API), ProsocialAPI, will allow developers to integrate functions into games including visual sensing, identification of prosocial signals from in-game actions, personalised adaptation of game elements, player profiles, game mechanics and expressive virtual characters, and support for data collection with protection of personal data. SMEs from the traditional game industry will work together with serious games companies to produce a series of exciting digital games targeting European schools. Through a multi-disciplinary collaboration between industry, researchers, psychologists, pedagogists and teaching professionals, ProsocialLearn will address complex factors associated with child development and advanced ICT in school curricula. Two SMEs within the consortium will produce an initial set of games and additional SMEs will be incorporated in the third year of the project to foster market creation. Both short term and longitudinal studies (pilots) will be conducted at schools across Europe to build scientific evidence of the benefits of prosocial gaming in different cultural settings and scales, and to explore business models, business plans and verify financial viability of the ProsocialLearn platform.;4197071,25;3448102,13;H2020-ICT-2014-1;IA;ATOS SPAIN SA;ES;"PlayGen Ltd;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;KUNGLIGA TEKNISKA HOEGSKOLAN;REDIKOD AB;UNIVERSITY OF SOUTHAMPTON;ELLINOGERMANIKI AGOGI SCHOLI PANAGEA SAVVA AE;ISTITUTO COMPRENSIVO STATALE B. LORENZI FUMANE VR";"UK;EL;SE;IT"; 194448;646495;Bioenergy4Business;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.3.1.;H2020-EU.3.3.2.";LCE-14-2014;H2020;Uptake of Solid Bioenergy in European Commercial Sectors (Industry, Trade, Agricultural and Service Sectors) Bioenergy for Business;1/01/2015;31/08/2017;;"'A consortium led by the Austrian Energy Agency (AEA) developed the project 'Uptake of Solid Bioenergy in European Commercial Sectors (Industry, Trade, Agricultural and Service Sectors) Bioenergy for Business' for the EU-Programme Horizon 2020s Call 2014 (LCE14). The project partners include a combination of energy agencies, national biomass associations and research-oriented partners with specialized knowledge on biomass from Northern, Southern, Central and Eastern Europe (Finland, Denmark, the Netherlands, European Biomass Association (AEBIOM), Germany, Austria, Slovakia, Croatia, Greece, Poland, Romania, Bulgaria and Ukraine).
The goal of this project is to support and promote the (partial) substitution of fossil fuels (coal, oil, gas) used for heating, by available bioenergy sources (industrial wastes, forest biomass, straw and other agricultural biomass) in the partner countries and beyond. In this context, the project will contribute to increase much-needed security of energy supply through lower dependence on fossil fuels from politically volatile sources. Target groups are, on the one hand, owners and operators of industrial heating plants (for private or district heating). On the other hand, actors who play an important role with regard to the value chain and to framework conditions crucial for the use of bioenergy heat will also be involved.
Activities will be tailored to the needs of actors relevant to promising market segments in the industrial, commercial, services and agriculture sectors. Results of the project will include information about market potentials, capacity building/training, decision-support tools and communication activities targeted at relevant stakeholder, tools to support the careful assessment, planning and implementation of such projects, and dissemination of best-practice business models. Additionally, information about best practice support measures and policies will be made available.'";1540713,75;1540713,75;H2020-LCE-2014-3;CSA;OSTERREICHISCHE ENERGIEAGENTUR AUSTRIAN ENERGY AGENCY;AT;"SLOVENSKA INOVACNA A ENERGETICKA AGENTURA;CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;TEKNOLOGISK INSTITUT;Association europeenne pour la biomasse;MOTIVA OY;NAUKOVO-TEHNICHNII CENTAR BIOMASA LLC;NACIONALNA ASOCIACIA PO BIOMASA;KRAJOWA AGENCJA POSZANOWANIA ENERGII SPOLKA AKCYJNA;ENERGETSKI INSTITUT HRVOJE POZAR;MINISTERIE VAN ECONOMISCHE ZAKEN;DBFZ DEUTSCHES BIOMASSEFORSCHUNGSZENTRUM GEMEINNUETZIGE GMBH;ROMANIAN ASSOCIATION OF BIOMASS AND BIOGAS";"SK;EL;DK;BE;FI;UA;BG;PL;HR;NL;DE;RO"; 194136;644024;CLARUS;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;A FRAMEWORK FOR USER CENTRED PRIVACY AND SECURITY IN THE CLOUD;1/01/2015;31/12/2017;;"Although cloud computing offers many benefits, security issues such as confidentiality and privacy are still major concerns to those intending to migrate to the cloud. Traditional cloud security has been based on assurance to customers that cloud providers follow sound security practices. As a result, current security mechanisms are commonly located within the cloud platform, hence compelling customers to trust cloud providers. However, customers might be reluctant to outsource sensitive data due to lack of control over data storage and management. To reach its full potential, cloud computing needs solid security mechanisms that enhance trust in cloud computing by allowing cloud customers to have a greater control over the security and privacy of their data. Moreover, it is also necessary to consider countermeasures to ensure that vulnerabilities or attacks do not have a negative impact on cloud security and that applications continue to operate and provide a good level of service even during an attack.

The main objective of CLARUS is to enhance trust in cloud computing services by developing a secure framework for the storage and processing of data outsourced to the cloud that allows end users to monitor, audit and retain control of the stored data without impairing the functionality and cost-saving benefits of cloud services. The CLARUS solution will provide the end user with a dedicated proxy located in a trusted domain implementing security and privacy features towards the cloud provider. The proxy is intended to be deployed within the client computer, in a server within the users domain, in an edge device (e.g. a router), or in any other location trusted by the user. CLARUS will also provide a set of security auditing services enabling the user to supervise the security operations performed by the CLARUS framework as well as other trust-enhancing features.";4193548;4193548;H2020-ICT-2014-1;RIA;UNIVERSITAT ROVIRA I VIRGILI;ES;"THALES SERVICES SAS;EURECOM;FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA;AKKA INFORMATIQUE ET SYSTEMES;MONTIMAGE EURL;OFFIS EV;KATHOLIEKE UNIVERSITEIT LEUVEN;ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE;TRUST-IT SERVICES LIMITED";"FR;ES;DE;BE;UK"; 194289;645149;CP-SETIS;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Towards Cyber-Physical Systems Engineering Tools Interoperability Standardisation;1/03/2015;31/05/2017;;"CPS require multiple engineering competences across various engineering disciplines. The development of such systems is a huge challenge, also because of the heterogeneity of engineering tools involved in development platforms across the development lifecycle. In order to overcome this challenge, past and on-going EU research projects have developed the basis for an International Open Standard for Development Tool Interoperability, the so called Interoperability Specification (IOS). However, due to lack of coordination, current IOS related activities, especially with respect to its standardization and possible extensions, are un-coordinated, endangering the huge financial effort that has been put into the IOS and the chance to establish it as a formal Standard.
The main goal of CP-SETIS is to conceive and set up a sustainable organizational structure as a platform joining all stakeholders, to coordinate all IOS related activities, especially the formal standardization and further extensions of the IOS. This organizational structure will be implemented within existing, sustainable European organizations, like the ARTEMIS-IA Working Groups or similar, that are open to all stakeholders.
CP-SETIS will ensure the support of all stakeholders for this structure, its operational rules, its implementation within existing structures and, most important, their commitment to coordinate all IOS related activities within this structure.
In this way, CP-SETIS will secure the huge effort both in terms of manpower as well as in terms of financial support that has been put into the IOS, furthering and enabling the setup of the IOS as a formal standard, and enabling the enormous innovation potential of the IOS both, for innovations in interoperable tools with new functionalities needed for future generations of Cyber-Physical Systems, and for innovations in future CPS themselves.
CP-SETIS will also use lessons learned during this process to update Standardization Research Agendas.";780000,37;698895;H2020-ICT-2014-1;IA;SafeTRANS e.V.;DE;"AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;KUNGLIGA TEKNISKA HOEGSKOLAN;AVL LIST GMBH;ARTEMISIA VERENIGING;SIEMENS AKTIENGESELLSCHAFT;OFFIS EV;THALES GLOBAL SERVICES SAS";"AT;SE;NL;DE;FR"; 194176;644260;INTELUM;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;International and intersectoral mobility to develop advanced scintillating fibres and Cerenkov fibres for new hadron and jet calorimeters for future colliders;1/03/2015;28/02/2019;;"Currently, new concepts are being considered for hadron and jet calorimetry in high energy physics experiments, in order to improve the energy resolution of these detectors by a factor of at least two. This is a prerequisite for future studies at the high luminosity, large hadron collider as well as at future electron and proton colliders. Amongst the few concepts being proposed, scintillating and ?erenkov fibres are considered very promising candidates.

The INTELUM project will be a 4 year project funding international, industry-academia exchanges to develop micro-pulling-down crystal growth and other new types of fibre technology. This new fibre production technology has the potential to enable fast, low-cost, manufacture of heavy crystal scintillating fibres.

In order to prove the new fibre technology concept, two key technical issues will be addressed during the project:

demonstrate feasibility of producing between 20-200km of fibres with consistent quality and well defined production costs
demonstrate sufficient radiation hardness of the fibres that the degradation of their optical properties is below 10% at 1 MGy level

This ambitious project will be undertaken by a truly international consortium of sixteen institutes and companies, many closely linked to the Crystal Clear Collaboration. The project will also lead to important impacts in other domains such as functional medical imaging and homeland security.";1093500;922500;H2020-MSCA-RISE-2014;MSCA-RISE;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;"FIBERCRYST SAS;PRYSMIAN;FYZIKALNI USTAV AV CR V.V.I;INTELLIGENTSIA CONSULTANTS SARL;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;JUSTUS-LIEBIG-UNIVERSITAET GIESSEN;UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA";"FR;IT;CZ;LU;DE"; 194341;645595;BeFOre;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Bioresources For Oliviculture;1/02/2015;31/01/2019;;The project aims at establishing a multi-lateral network of research and innovation staff active in olive germplasm access, conservation, evaluation and exploitation, strengthening research capacities through the exchange of knowledge and expertise on a shared research programme focused on developing integrated common protocols to phenotype and characterize plants at molecular, morphological and physiological level, and evaluating the olive oil quality related to varieties. The scientific results of the project will contribute at improving the potential of the olive germplasm collections, repositories and banks as main sources of variability and of the evaluation tools to be used to increase oliviculture sustainability. Particular attention will be paid to issues concerned to international intellectual property rights for conserving, exchanging and using the olive genetic resources. Another aim is to create a long lasting network among partners also promoting new common projects in the frame of Horizon2020 and other international funding sources. The joint exchange programme will involve 9 beneficiaries and 6 partners belonging to AC and NAC sectors and will be performed through a series of short and long term staff exchanges and workshops among European (Italy, Spain, Greece and France) and third countries (Morocco, Lebanon, Jordan, Argentina, Chile and Mexico). The International Olive Council (IOC), represented by IOC Executive Director, Jean-Louis Barjol, expressed its strong support to BeFOre planning to play an important role in dissemination activities. Experienced and early stage researchers, technicians and managers, are expected to be exchanged between EU and TC to ensure a good scientific transfer of knowledge and training. Enhancement of careers for the staff involved is expected. The project coordination and management will be ensured by the contribution of a well established coordination group and a Steering Committee.;1296000;1296000;H2020-MSCA-RISE-2014;MSCA-RISE;CONSIGLIO NAZIONALE DELLE RICERCHE;IT;"CONFEDERAZIONE ITALIANA AGRICOLTORI REGIONALE UMBRIA;SYNDESMOS BIOMHCHANON TYPOPOIHTON EXAGOGON ELAIOLADOY;MEDITERRANEAN AGRONOMIC INSTITUTE OF CHANIA;INSTITUTO ANDALUZ DE INVESTIGACIONY FORMACION AGRARIA PESQUERA ALIMENTARIA Y DE LA PRODUCCION ECOLOGICA;INSTITUT NATIONAL D'ETUDES SUPERIEURES AGRONOMIQUES DE MONTPELLIER;AGRICULTURAL UNIVERSITY OF ATHENS;UNIVERSITA DEGLI STUDI DI PERUGIA;OPTIMUM QUALITY SL";"IT;EL;ES;FR"; 194225;644629;AutoPost;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Deformable Surface Tracking and Alpha Matting for the Automation of Post-production Workflows;1/01/2015;30/06/2016;;"In todays era of automation and intelligent systems, a huge amount of video and film post-production work can still only be completed manually by specialized artists. In the case of visual effects (VFX) and 2D/3D conversion, artists spend about 20%-40% of their time doing labour-intensive additive and subtracting retouching.
To address this issue, AutoPost will develop productive end-user solutions for small and medium post-houses, by embedding scientific state-of-the-art solutions for tracking deformable surfaces and natural video matting into the established workflow of visual effects and 2D-to-3D conversion artists. The AutoPost solutions will considerably reduce the workload and will make post-production performance more efficient, both creatively and financially, while still allowing supervision and artistic control of the results by the user.
To ensure a professional adoption, the developed tools will be accessible through a general plugin suite, The AutoPost Plugin Suite, for industry-standard post-production platforms as well as SDKs and functional plugin prototypes. The developments will be accomplished in accordance with the real-world working requirements defined by SME project partners from the creative industries, who will act as stakeholders for other post-houses, end-users and further external partners from their networks.
AutoPosts tools will allow companies to reduce the weight of the labour cost factor in their competitive profile, aiming to boost the competitiveness of the EU post-houses in every market, especially since infrastructure and labour costs can dictate where in the world films are finally produced.
To fulfil AutoPosts objectives, a complementary and compact group of engineers, VFX and 2D/3D conversion artists, compositing experts and business-related professionals will work together, specifying, developing and evaluating the tools.";1092750;948150;H2020-ICT-2014-1;IA;FUNDACIO BARCELONA MEDIA UNIVERSITAT POMPEU FABRA;ES;"MOTO GMBH;IMCUBE LABS GMBH;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;MOVIES BENELUX;S.A. IMAGES ET CINEMA";"DE;BE"; 194216;644564;BigDataEurope;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;Integrating Big Data, Software and Communities for Addressing Europes Societal Challenges;1/01/2015;31/12/2017;;"BigDataEurope will provide support mechanisms for all the major aspects of a data value chain, in terms of the employed data and technology assets, the participating roles and the established or evolving processes. The effectiveness of the provided support mechanisms will be assessed in different domains pertaining to Europes major societal challenges with respect to the needs and requirements of the related communities. To this end, BigDataEurope focuses on providing an integrated stack of tools to manipulate, publish and use large-scale data resources; tools that can be installed and used freely in a customised data processing chain with minimal knowledge of the technologies involved and integrating and industrially hardening key open-source Big Data technologies and European research prototypes into a Big Data Integrator Platform, i.e. an ecosystem of specifications and reference implementations that are both attractive to current players from all parts of the data value chain while also lowering the entry barrier for new businesses.
In order to realise its objectives, Big Data Europe will focus on two clearly defined coordination and support measures:
1. Coordination: Engaging with a diverse range of stakeholder groups representing particularly the Horizon 2020 societal challenges Health, Food & Agriculture, Energy, Transport, Climate, Social Sciences and Security; Collecting requirements for the ICT infrastructure needed by data-intensive science practitioners tackling a wide range of societal challenges; covering all aspects of publishing and consuming semantically interoperable, large-scale data and knowledge assets;
2. Support: Designing, realizing and evaluating a Big Data Aggregator platform infrastructure that meets requirements, minimises the disruption to current workflows, and maximises the opportunities to take advantage of the latest European RTD developments, including multilingual data harvesting, data analytics, and data visualisation.
BigDataEurope will implement and apply two main instruments to successfully realize these coordination and support measures:
a) Build Societal Big Data Interest Groups in the W3C interest group scheme and involving a large number of stakeholders from the Horizon 2020 societal challenges as well as technical Big Data experts;
b) Design, integrate and deploy a cloud-deployment-ready Big Data aggregator platform comprising key open-source Big Data technologies for real-time and batch processing, such as Hadoop, Cassandra and Storm.
BigDataEurope aims to provide an adaptable, easy to deploy and use solution, which will allow the interest-ed user groups and stakeholders to extend their Big Data solutions or introduce Big Data technology to their business processes, based on a concrete methodology for producing a technically sound solution and maximizing its outreach to the relevant communities.";4984238,75;4984238,75;H2020-ICT-2014-1;CSA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;DE;"ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS FAO;CENTRE FOR RENEWABLE ENERGY SOURCES AND SAVING FONDATION;STICHTING VU;AGRO-KNOW;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;INSTITUT FUR ANGEWANDTE INFORMATIK (INFAI) EV;SEMANTIC WEB COMPANY GMBH;CESSDA AS;GEIE ERCIM;EUROPEAN UNION SATELLITE CENTRE;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN;""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS"""""";TENFORCE BVBA;OPEN PHACTS FOUNDATION LBG";"EL;IT;NL;BE;DE;AT;NO;FR;ES;UK"; 194249;644839;CENTAURO;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Robust Mobility and Dexterous Manipulation in Disaster Response by Fullbody Telepresence in a Centaur-like Robot;1/04/2015;30/09/2018;;"Disaster scenarios, like the Fukushima nuclear accident, clearly show that the capabilities of today's disaster response robots are not sufficient for providing the needed support to rescue workers. The CENTAURO project aims at development of a human-robot symbiotic system where a human operator is telepresent with its whole body in a Centaur-like robot, which is capable of robust locomotion and dexterous manipulation in the rough terrain and austere conditions characteristic of disasters. The CENTAURO robot will consist of a four-legged basis and an anthropomorphic upper body and will be driven by lightweight, compliant actuators. It will be able to navigate in affected man-made environments, including the inside of buildings and stairs, which are cluttered with debris and partially collapsed. The Centauro system will be capable of using unmodified human tools for solving complex bimanual manipulation tasks, such as connecting a hose or opening a valve, in order to relieve the situation. A human operator will control the robot intuitively using a full-body telepresence suit that provides visual, auditory, and upper-body haptic feedback. Rich sensors will provide the necessary situation awareness.
Robot percepts and suggested actions will be displayed to the operator with augmented reality techniques. For routine manipulation and navigation tasks, autonomous robot skills will be developed. This will allow for taking the operator partially out of the control loop, which will be necessary to cope with communication latencies and bandwidth limitations and to reduce the operator workload.
A series of increasingly complex tests with corresponding evaluation criteria will be devised from end-user requirements to systematically benchmark the capabilities of the developed disaster response system.";4124915;4124915;H2020-ICT-2014-1;RIA;RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN;DE;"LINKOPINGS UNIVERSITET;SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;KUNGLIGA TEKNISKA HOEGSKOLAN;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA;KERNTECHNISCHE HILFSDIENST GMBH;PROGENOX GMBH";"SE;IT;DE"; 194134;644021;TWIST DIGITAL;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;Transregional Web Innovative Services for Thriving Digital and Mobile Entrepreneurship;1/01/2015;31/12/2016;;"TWIST project aims at connecting four existing local web entrepreneurship startup ecosystems and hubs, providing new services for web entrepreneurs aiming at scaling up and competing in the global market.
TWIST consortium includes partners from four cities and regions with complementary profiles and assets: Warsaw, Lille, Rome, and Stockholm .The involved organizations are characterized by a similar typology of skills and expertise and can be classified into two main groups: accelerators, i.e. young, promising and already successful accelerators wishing to enlarge their collaborations and financial investors and/or services providers, acting as direct investors leveraging with private seed funds and/or, at the same time, providing highly qualified services for startups looking for equity funds or scaling up. TWIST key objectives are: support the creation of competitive startups in web and mobile sector, exchanging methodologies and competencies among the four ecosystems stakeholders, promote activities to cut the high failure rate of startups, favour cross-fertilization and funding opportunities. To reach its goals TWIST will provide: mentoring and coaching services for better understanding business models, financial technicalities for accessing finance for growth; a customized online platform to facilitate the meetups of web entrepeneurs with vertical,technical and legal experts, serial entrepreneurs and big industries; the creation of co-working laboratories and the organization of challenges for startups with the involvement of big players; pitching events with investors during the main international events . In line with Startup Europe Partnership (SEP) and with the specific call priorities, TWIST platform will focus on web entrepreneurs and will support them with services aiming at: valorizing the talents, favouring a better access to capital, developing the concept of co-living and co-working and link the startups ecosystems across EU.";1837773,22;1325100;H2020-ICT-2014-1;IA;LAZIO INNOVA - SOCIETA PER AZIONI;IT;"MEDIA DEALS UG (HAFTUNGSBESCHRNKT);SPRINGFELLOW INTERNATIONAL AB;SEEDCAP AB;FUNDACJA NEO MEDIA;META GROUP POLSKA SP. ZOO;MORETIME PROFESSIONAL SERVICES AB (PUBL);ENLABS SRL;Media deals;HUGIN&MUNIN SL;EURATECHNOLOGIES";"DE;SE;PL;IT;FR;ES"; 194155;644114;fromROLLtoBAG;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;Consumer Driven Local Production with the Help of Virtual Design and Digital Manufacturing;1/01/2015;30/06/2016;;"Consumer Driven Local Production with the Help of Virtual Design and Digital Manufacturing.

Objectives:
To connect enabling virtual design and sales technology to enabling digital manufacturing technology and demonstrate their advantages and benefits;
To demonstrate how virtual design and sales technology can be exploited by the fashion and sports goods industry and how, by means of such technology, consumer driven local production can be established.
To accelerate and support the growth of European creative industries, especially in competing against low cost imports and bring production back to Europe;
Through efficient dissemination create tens of innovative solutions with high market potential for the European creative industries SMEs.

How they will be achieved:
A study of consumer attitudes and preferences towards interactive sales networks and customization sets the basis for the project. In order to utilize already available technology and to aim beyond the state-of-the-art, a Kick-Off Round Table Workshop will be organized at the beginning with wide participation by suitable IT suppliers.
The novelties of the project are the inspiring and interactive avatar, radically new product construction system connected to no-inventory continuous from-roll-to-bag production, plus connecting digital consumer driven design to consumer driven manufacturing.
The results of the project will be efficiently demonstrated by Road Show Workshops to be organized throughout Europe in cooperation with local Industry Associations.

Relevance to the work programme:
The project will stimulate collaboration between ICT innovative technology providers and creative industry SMEs for wider adaption and deployment of innovative digital solutions.
The aim is to accelerate and support the growth of European creative industries by improving their competitiveness and by bringing production back to Europe.";1180641,25;806609,88;H2020-ICT-2014-1;IA;TTY-SAATIO;FI;"LECTRA BENELUX NV;CYBERLIGHTNING OY;Alu Group S.L.;HOEGSKOLAN I BORAS;DOULOU NV;MIRALAB SARL;PRINTSCORPIO OY;AMER SPORTS OYJ";"BE;FI;ES;SE;CH"; 194217;644571;SHARCS;SIGNED;H2020-EU.2.1.1.;ICT-32-2014;H2020;Secure Hardware-Software Architectures for Robust Computing Systems;1/01/2015;31/12/2017;;"Developing new security paradigms, architectures, and software, for more secure and trustworthy ICT systems and services has clear social, scientific, and market motivation. This motivation is becoming stronger due to the changing threat landscape; over the past decade we are witnessing an ever-increasing amount of cyberattacks on the Internet.
We believe that to advance the field of cybersecurity, we must act proactively and in synergy, instead of being reactive to cyberattacks.

We propose SHARCS, a framework for designing, building and demonstrating secure-by-design applications and services, that achieve end-to-end security for their users. SHARCS will achieve this by systematically analyzing and extending, as necessary, the hardware and software layers in a computing system. This holistic approach is necessary, as no system can truly be secure unless every layer is secured, starting from the lowest one. We will measure the effectiveness of the SHARCS framework by using it on a diverse set of security-critical, real-word applications. The applications have been chosen from three different domains, medical, cloud and automotive, to demonstrate the platform independence capabilities of SHARCS. SHARCS will provide a powerful foundation for designing and developing trustworthy, secure-by-design applications and services for the Future Internet.";3105762,5;3105762,5;H2020-ICT-2014-1;RIA;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;"ONAPP LIMITED;STICHTING VU;CHALMERS TEKNISKA HOEGSKOLA AB;TECHNISCHE UNIVERSITAT BRAUNSCHWEIG;ELEKTROBIT AUTOMOTIVE GMBH;IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD;NEURASMUS BV";"GI;NL;SE;DE;IL"; 194274;645028;EuConNeCts 2;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;European Conferences on Networks and Communications (EuCNC);1/03/2015;31/08/2017;;"It is the purpose of EuConNeCts 2, a Supporting Action, to organise the following 2 editions, 2016 and 2017, of the EC sponsored conference in the area of communication networks and systems (EuCNC - European Conference on Networks and Communications). EuCNC will serve as a technical and scientific conference for researchers, namely European ones, to show their work in the area of Telecommunications, focusing on communication networks and systems, but reaching services and applications. However, the conference will not be restricted to European researchers, rather aiming at attracting others from all the other regions in the world. It will also serve as a showcase for the work developed by projects co-financed by the EC, namely those addressing Objective ICT-2014.6 (Smart optical and wireless network technologies), but also including the new projects arising from other H2020 calls. Nonetheless, it also aims at attracting works in the area of communication networks and systems from other objectives. EuCNC will: 1) be a European conference, but with a large international dimension; 2) showcase the R&D activities performed within EC programmes, directly and indirectly; 3) showcase the cooperation in R&D between European organisations and worldwide ones; 4) bridge between academia / research centres and industry; 5) coordinate its goals with the EC and the main European players; 6) be a high-quality R&D conference; 7) be a well-recognised conference in Telecommunications; 8) provide a forum for the presentation of state-of-the-art technology, in both theoretical and experimental forms; 9) communicate the research results to the wide audience of the general public; 10) foster the participation of both established researchers and students, as well as industry members from various areas; 11) be a transparent and not-for-profit conference; 12) positively differentiate itself from other conferences, which will be achieved by reaching all previous objectives.";305370;305369,75;H2020-ICT-2014-1;CSA;INOV INESC INOVACAO - INSTITUTO DE NOVAS TECNOLOGIAS;PT;"UNIVERSITY OF PIRAEUS RESEARCH CENTER;OULUN YLIOPISTO;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS";"EL;FI"; 194433;646436;RiCORE;SIGNED;"H2020-EU.3.3.7.;H2020-EU.3.3.2.4.;H2020-EU.3.3.2.2.;H2020-EU.3.3.2.1.";LCE-04-2014;H2020;Risk Based Consenting of Offshore Renewable Energy Projects;1/01/2015;30/06/2016;;"The consenting of offshore renewable energy is often cited as one of the main non-technical barriers to the development of this sector. A significant aspect of this is the uncertainty inherent in the potential environmental impacts of novel technology. To ensure consents are compliant with EU and national legislation, such as the Environmental Impact Assessment and Habitats Directive, costly and time consuming surveys are required even for required even for perceived lower risk technologies in sites which may not be of highest environmental sensitivity. It is therefore the aim of the RiCORE project to establish a risk-based approach to consenting where the level of survey requirement is based on the environmental sensitivity of the site, the risk profile of the technology and the scale of the proposed project. RiCORE will study the legal framework in place in the partner Member States to ensure the framework developed will be applicable for roll out across these Member States and further afield.

The next stage of the RiCORE project is to consider the practices, methodologies and implementation of pre-consent surveys, post-consent and post-deployment monitoring. This will allow a feedback loop to inform the development of the risk-based framework for the environmental aspects of consent and provide best practice. The project will achieve these aims by engaging with the relevant stakeholders including the regulators, industry and EIA practitioners, through a series of expert workshops and developing their outcomes into guidance.

The impact of the project will be to improve, in line with the requirements of the Renewable Energy Directive specifically Article 13 (1), consenting processes to ensure cost efficient delivery of the necessary surveys, clear and transparent reasoning for work undertaken, improving knowledge sharing and reducing the non-technical barriers to the development of the Offshore Renewable Energy sector so it can deliver the clean, secure energy";1393532,5;1393532,5;H2020-LCE-2014-3;CSA;THE ROBERT GORDON UNIVERSITY;UK;"UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;E-CUBE STRATEGY CONSULTANTS;MARINE SCOTLAND;FUNDACION AZTI - AZTI FUNDAZIOA;WAVEC/OFFSHORE RENEWABLES - CENTRO DE ENERGIA OFFSHORE ASSOCIACAO";"IE;FR;UK;ES;PT"; 194234;644683;ODINE;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;Open Data INcubator for Europe;1/02/2015;31/07/2017;;"The Open Data INcubator for Europe (ODINE) project will set up an environment to support and advice SMEs and start-ups in creating commercial added value from open data. Drawing on the experience from key players in the consortium including Wayra (an incubator/accelerator), Fraunhofer IAIS and the ODI (both data facilitators and incubators), Telefonica (providing computing infrastructure and strong links to data protection and privacy stakeholders), and the University of Southampton (renowned for its open data research and home of Sir Tim Berners-Lee and Sir Nigel Shadbolt), we plan to establish a EU-wide, industry-focused network of open data companies around Europe, promoted and guided by the trusted authorities and commentators at the Guardian and OKFN. To achieve this we shall take an approach that follows best in class practice for incubators and which makes it as a simple and smooth as possible for SMEs to apply for help. We will offer: (i) a transparent, fair, and efficient proposal process for SMEs and start-ups, based around Wayra, IAIS and ODIs existing and successful processes; (ii) a network of European open data SMEs and start-ups; (iii) initial investment in these companies through an open call; (iv) incubation and mentoring by ODI, Fraunhofer and Wayra academies, with the possibility of acceleration via Wayra, Telefonica Ventures, and Fraunhofer Venture; (v) access to data services and computing infrastructure from IAIS, ODI, OKFN and Telefonica; (vi) expert support from serial entrepreneurs and intrapreneurs, and coaching from business schools; as well as (vii) high visibility through promotion of success stories by the Guardian, ODI and the OKFN. A successful open data incubator will significantly help Europe to regain leadership in technical innovation, balanced with the ethical treatment of data for which the public are crying out, and to create skilled jobs that help Europe become more productive and competitive in the 21st Century.";8228856,25;7882980,5;H2020-ICT-2014-1;IA;UNIVERSITY OF SOUTHAMPTON;UK;"WAYRA INVESTIGACION Y DESARROLLO SL;OPEN DATA INSTITUTE LBG;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;TELEFONICA INVESTIGACION Y DESARROLLO SA;OPEN KNOWLEDGE FOUNDATION DEUTSCHLAND;Guardian News and Media Ltd";"ES;UK;DE"; 194201;644386;ACE Creative;SIGNED;H2020-EU.2.1.1.4.;ICT-18-2014;H2020;ACE Creative: Harnessing the strengths of innovation multipliers to accelerate creative industry growth through an integrated ecosystem of supports in finance, market access and technology exploitation.;1/01/2015;31/12/2016;;"InnoCreate is an ambitious coordination and support action aiming to stimulate the growth of the creative industries in Europe by overcoming challenges at individual SME level (small size, problems with access to finance, barriers to new market entry), at the innovation support level (disparity in availability and quality of support) and at overall creative industry level (fragmentation, localisation). InnoCreate will respond by networking innovation support players and harnessing their regional strengths into a European ecosystem of supports to respond more effectively to SME needs.
Two specific end user groups of SMEs will be targeted through InnoCreate: creative industry SMEs exploiting advanced technologies and ICT SMEs innovating in the field of creative industries. Both of these target groups will be equally supported. SMEs will benefit from an imaginative programme of communication and support actions: InnoCreate will piggy-back on the Creative Business Cup to raise awareness about the ICT Challenge competition, network SMEs throughout Europe at the InnoCreate International Camps and provide customised one to one supports for the most promising SMEs with high growth potential.
InnoCreate galvanises existing structures by bringing together three strong existing European networks EBN, CKO and the ECB Network and a network of innovation multipliers at regional level. The InnoCreate service offering aims to be immediately accessible online and on-site in 15 EU partner and associate partner countries with a target of engaging further stakeholders to deliver the support services in all EU member states by the project end. The impact of InnoCreate will be tangible for individual SMEs, for innovation support actors and for the growth of the European creative industries as a whole.";998419,12;998419,06;H2020-ICT-2014-1;CSA;EUROPEAN BUSINESS AND INNOVATION CENTRE NETWORK AISBL;BE;"CREATIVE BUSINESS CUP;CENTER FOR KULTUR- OG OPLEVELSESOKONOMI;MEDIA DEALS UG (HAFTUNGSBESCHRNKT);BWCON GMBH;STICHTING EUROPEAN CREATIVE BUSINESS NETWORK;TECHNOPORT SA;NOVITECH AS;STICHTING NEDERLANDS INSTITUUT VOOR BEELD EN GELUID;NORIBIC LIMITED;META Group S.R.L;Media deals;ASOCIACION CENTRO EUROPEO DE EMPRESAS E INNOVACION DEL PRINCIPADO DE ASTURIAS";"DK;DE;NL;LU;SK;UK;IT;FR;ES"; 194119;643950;SecondHands;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;SecondHands: A Robot Assistant For Industrial Maintenance Tasks;1/05/2015;30/04/2020;;"The subject of this proposal is a robot assistant that is trained to understand maintenance tasks so that it can either pro-actively or as a result of prompting, offer assistance to maintenance technicians performing routine and preventative maintenance. Conceptually the robot's task is to provide a second pair of hands to the maintenance engineer, such that once the robot has been trained it can predict when and how it can usefully provide help.

The robot's behavioural repertoire is learnt in a training phase that includes the monitoring of maintenance technician activity, the construction of a knowledge base that describes the context of a task, and a theory of action that enables dynamic behaviour generation. The result is a set of competencies coupled with an ability to recognise the state of a task and an understanding of how these competencies can be usefully deployed given the state.

The scope of work includes the construction of a robot assistant, the systems that facilitate the training, the actual training on a number of representative tasks, perceptual systems that facilitate activity recognition, and validation of the system's ability to usefully contribute to tasks in collaboration with a maintenance engineer. Assessment of the system will test its ability to recognise when it doesn't know something as well as its ability to generalise its knowledge to previously unseen tasks.";6930000;5994000;H2020-ICT-2014-1;RIA;OCADO GROUP PLC;UK;"ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;KARLSRUHER INSTITUT FUER TECHNOLOGIE;UNIVERSITY COLLEGE LONDON;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA";"CH;DE;UK;IT"; 194355;645668;SALEACOM;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Overcoming Inequalities in Schools and Learning Communities: Innovative Education for a New Century;1/01/2015;31/12/2017;;"Overcoming Inequalities in Schools and Learning Communities: Innovative Education for a New Century (SALEACOM here after) proposes the collaboration between 7 research groups (Australia, Brazil, New Zealand, Hungary, South Africa, Spain, USA) and 1 non academic institution (Drom Kotar Mestipen) with a global scope to address educational and social exclusion in schools and learning communities. SALEACOM seeks to create an International Research Network that has the following aims: (i) to increase worldwide cooperation in the study of successful actions with children and youth systematically underserved; (ii) to provide high-quality training programs for teachers and educational researchers aiming at overcoming inequalities; (iii) to develop interdisciplinary solutions for and with learners most heavily affected by inequalities, including access and quality of higher education; (iv) to design strengths-based methodologies for international comparative research to further the impact of research on the lives of students who have been historically excluded (v) to create a global program of successful educational actions to be implemented across educational systems. To promote coherent and effective cooperation among the research team, it accounts for the inclusion of researchers across disciplines, stages in their careers and cultures, committed to conducting strengths-based international research to further impact the lives of students who have been traditionally unsuccessful in educational contexts. To maximise the research outcomes of this proposal, researcher exchanges are based on partners complementarities in skills, methodological expertise and knowledge of several excluded populations that face similar challenges globally (i.e. Roma, Indigenous populations, African American, among others.). In parallel to developing interdisciplinary successful educational actions in schools and learning communities, we will explore paradigms, principles and practices.";499500;391500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITAT ROVIRA I VIRGILI;ES;"ASOCIACION GITANA DE MUJERES DROM KOTAR MESTIPEN DE BARCELONA;UNIVERSITAT DE BARCELONA;UNIVERSITAT AUTONOMA DE BARCELONA;KOZEP-EUROPAI EGYETEM";"ES;HU"; 194438;646440;CITYKEYS;SIGNED;H2020-EU.3.3.1.3.;SCC-02-2014;H2020;Smart City performance measurement system;1/02/2015;31/01/2017;;"The European Commission has developed two parallel approaches to support the implementation of smart urban technologies: the creation of 'lighthouse projects' (large scale demonstration of technology in cities and communities) and 'horizontal activities' to address specific challenges (e.g. regulatory barriers, in standardisation, public procurement and performance monitoring). CITYKEYS project is within the context of these horizontal activities. The mission of CITYKEYS is to develop, and validate, a holistic performance measurement framework for future harmonized and transparent monitoring and comparability of the European cities activities during the implmeatation of Smart City solutions. The work methodology will be based on the following key factors:
Extensive collaboration and communication with European cities.
Establish a baseline by analysis and integration of existing results from previous initiatives.
Develop a set of KPIs specific for Smart Cities initiatives evaluation and comparability
Smart solutions for transparent and open data collection and processing.
The tangible objectives of the CITYKEYS project are to:
1) Develop and validate a transparent performance evaluation framework: including KPIs definition, guidelines for data collections, performance system prototype and testing in case-cities.
2) Develop recommendations for the implementation of the performance system into the cities decision-making process and recommendations for the development of new business.
3) Engage stakeholders in identifying and exploiting opportunities for synergy and replicability; and establish a collaboration platform for European cities.
The consortium includes 3 multidisciplinary research organizations, 1 cities association and 5 partner cities covering different geographical regions in Europe and different urban realities. In addition to the 5 partner cities, 15 others shown their commitment to join the project stakeholders advisory group.";962846,25;962846,25;H2020-SCC-2014;CSA;TEKNOLOGIAN TUTKIMUSKESKUS VTT;FI;"EUROCITIES ASBL;AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH;GRAD ZAGREB;GEMEENTE ROTTERDAM;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;AYUNTAMIENTO DE ZARAGOZA;TAMPEREEN KAUPUNKI;MAGISTRAT DER STADT WIEN";"BE;AT;HR;NL;ES;FI"; 194140;644039;M3TERA;SIGNED;H2020-EU.2.1.1.1.;ICT-02-2014;H2020;Micromachined terahertz systems -a new heterogeneous integration platform enabling the commercialization of the THz frequency spectrum;1/02/2015;31/07/2018;;This project envisions the wide-spread use of low-cost THz technology in our society, enabled by the proposed micromachined heterogeneous integration platform, which provides an unprecedented way to highly-integrated, volume-manufactuable, cost- and energy-efficient, reconfigurable submillimeter-wave and terahertz (THz) systems. The proposed THz integration platform is envisioned to initiate an important transition in industrial microwave-systems manufacturing and is expected to finally enable the large-scale commercialization of the heavily sought-after frequency space between 100 GHz and 1 THz. In line with technology convergence of advancing microwave semiconductor technology according to internal and external roadmaps, the proposed THz microsystem platform is envisioned to accommodate multiple generations of future THz products in different application fields. The concrete business and lead application case is THz microsystems enabling compact, low-cost point-to-point high-speed communication links in the frequency space between 100 GHz and 500 GHz, to be deployed in a scenario of a high-density small-cell base-station network providing ubiquitous high-speed internet access to mobile communication devices in urban environment. The key technology end-user driving the primary prototype development and demonstration of a complete THz communication link is Ericsson. A secondary prototype developed in M3TERA is on a multi-function adaptive THz sensor platform for different millimeter-wave sensing applications in society, including food quality control and food safety monitoring, medical diagnosis, and industrial sensing. The key manufacturing partner in this industry-driven proposal is the high-volume semiconductor and microsystems manufacturer IFAT, who also provides system packaging concepts. Project management of this 3-years project with 7 participants in 4 EU countries is done by a professional company with an exceptional career track in EU project management.;4255743,75;3742961,25;H2020-ICT-2014-1;RIA;TECHNIKON FORSCHUNGS- UND PLANUNGSGESELLSCHAFT MBH;AT;"ANTERAL SL;CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT;KUNGLIGA TEKNISKA HOEGSKOLAN;CHALMERS TEKNISKA HOEGSKOLA AB;INFINEON TECHNOLOGIES AUSTRIA AG;ERICSSON AB";"ES;CH;SE;AT"; 194210;644453;TIPS;SIGNED;H2020-EU.2.1.1.1.;ICT-02-2014;H2020;Thermally Integrated Smart Photonics Systems;1/02/2015;31/01/2018;;"The objective of this proposal is to develop and demonstrate a scalable, thermally-enabled 3D integrated optoelectronic platform that can meet the explosion in data traffic growth within ICT. The Thermally Integrated Smart Photonics Systems (TIPS) program will heterogeneously integrate micro-thermoelectric coolers (?TEC) and micro-fluidics (?Fluidics) with optoelectronic devices (lasers, modulators, etc.) in order to precisely control device temperature and thus device wavelength compared to commercially available discrete technology.
Data traffic is projected to increase sharply (40-80? by 2020) and this is driving an increase in network complexity and the requirement for scalable optoelectronic integration. A major bottleneck to this large scale integration is thermal management. Active photonic devices generate extremely high heat flux levels (~1 kW/cm2) that must be efficiently removed to maintain performance and reliability; furthermore, active photonic devices must be controlled at temperature precision better than 0.1C. Todays thermal technology is at the limit and cannot scale with growth in the network. As a comparison, electronics produce lower heat flux levels (~100 W/cm2) and have a less restrictive temperature requirement of 852C.
Integration of thermal management onto optoelectronic devices has not been addressed to date in academic or industrial investigations and therefore presents a significant knowledge gap that must be filled to enable impact and ensure the EU is at the forefront of optoelectronic technology. While the end goal is driven by telecom or datacom industrial requirements there are many scientific knowledge gaps that will be filled by the TIPS consortium. The application space for a thermally-integrated smart optoelectronic solution is large and spans multiple communication length scales from long reach to inter/ intrachip communications as well as other applications like sensors that seek to leverage silicon photonics platforms";5230041,25;5230041;H2020-ICT-2014-1;RIA;UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK;IE;"LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V.;UNIVERSITAET HAMBURG;COMMUNICRAFT LIMITED;ALCATEL - LUCENT BELL LABS FRANCE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;UNIVERSITY OF LIMERICK;III-V LAB;LIONIX BV;Alcatel Lucent Ireland Limited";"DE;IE;FR;NL"; 194327;645487;MMT;SIGNED;H2020-EU.2.1.1.4.;ICT-17-2014;H2020;MMT will deliver a language independent commercial online translation service based on a new open-source machine translation distributed architecture;1/01/2015;31/12/2017;;"The goal of MMT is to deliver a language independent commercial online translation service based on a new open-source machine translation distributed architecture.

MMT does not require any initial training phase. Once fed with training data MMT will be ready to translate. MMT de-facto will merge translation memory and machine translation technology into one single product. Quality of translations will increase as soon as new training data are added.

MMT manages context automatically so that it will not require building domain specific systems. MMT will provide best translation quality for any topic/domain by storing training segments together with context linking information.

MMT enables scalability of data and users so that no more expensive ad-hoc hardware installations are needed. The MMT architecture will support high performance and linear scalability up to thousands of nodes. The same software will work to set-up a personal translation system or to create a web-based service on a cluster of commodity nodes able to handle terabytes of data and millions of users.

MMT will create a data collection infrastructure that accelerates the process of filling the data gap between large IT companies and the MT industry. MMT will leverage the data crawled on the web by Common Crawl, TAUS, Translateds MyMemory and Matecat data and facilities to set up a processing pipeline that will create unprecedented amounts of clean parallel and monolingual data to develop machine translation systems.";3695200;2994700;H2020-ICT-2014-1;IA;TRANSLATED SRL;IT;"THE UNIVERSITY OF EDINBURGH;TAUS B.V.;FONDAZIONE BRUNO KESSLER";"UK;NL;IT"; 194233;644678;TWEETHER;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;Traveling Wave Tube based W-band Wireless Networks with High Data Rate, Distribution, Spectrum and Energy Efficiency;1/01/2015;31/12/2017;;"Never technology has penetrated so deeply and fast in society everyday life as Internet has done in the last decades and is expected to do in the future. The enormous flux of data transferred via wireless networks, increasing at exponential pace, makes todays state of the art networks soon outdated. Large parts of the society are deprived of adequate access to Internet due to the high costs, long deployment time of optical fibres and inadequate performance of wireless networks. This inequality will most likely pertain in the next years.
Millimetre waves are the most promising solution to support the increasing data throughput and to be a credible fibre complement for the last miles.
The TWEETHER aim is to realise the millimetre wave Point to multi Point segment to finally link fibre, and sub-6GHz distribution for a full three segment hybrid network, that is the most cost-effective architecture to reach mobile or fixed final individual client. The TWEETHER project responds to the call H2020-ICT6, to foster smart wireless network architecture for high capacity everywhere outdoor data distribution, in gigabit class, that other technologies cannot support, at low operating cost. High spectrum and energy efficient W-band (92-95GHz) technology will be developed. A powerful and compact transmission hub based on a novel traveling wave tube power amplifier with performance precluded to any other technology and an advanced chipset in a compact terminal will be realised. The TWEETHER system will be tested in a real operating environment. Integrated smart networks of backhaul for 4G and 5G small cells and of access for residential houses are the targeted market that benefits from the actual light regulation of W-band.
A big company Thales Electron Devices, four SMEs, Bluwan, OMMIC, HFSE, Fibernova, and three top Universities, Lancaster, Goethe Frankfurt, Politecnica de Valencia, join their expertise to successfully tackle the formidable challenges of the TWEETHER project.";3333722,5;3333722,5;H2020-ICT-2014-1;RIA;LANCASTER UNIVERSITY;UK;"ERTE-ETUDES ET REALISATIONS DE TRAVAUX ELECTRONIQUES SAS;OMMIC SAS;THALES ELECTRON DEVICES SAS;BLUWAN;INSTITUT MINES-TELECOM;JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN;FIBERNOVA SYSTEMS SL;HF SYSTEMS ENGINEERING GMBH & CO KG;UNIVERSITAT POLITECNICA DE VALENCIA";"FR;DE;ES"; 194121;643956;Optintegral;SIGNED;H2020-EU.2.1.1.1.;ICT-03-2014;H2020;Advertisement displays manufactured by hybrid in-mould integration;1/02/2015;31/01/2018;;"OptIntegral develops and demonstrates LED displays for advertisement manufactured by in-mould hybrid integration of TOLAE electronics and photonics components.
The aim is to proof the flexibility and sustainability of the novel manufacturing process enabling a diversity of LED display products competitive with EU-labour cost.
Three different large area displays: 3D glasses free, lightpipe and backlight, will be demonstrated by three SMEs. The novel manufacturing process combines Roll-to-Sheet and Roll-to-Roll of flexible electronics with In-mould hybrid integration of the optoelectronics with the optics.
The novel displays harvest the intrinsic TOLAE benefits with thin, light weight, and bendable structures; and the specific in-mould integration benefits of a) automating the current manual assembly with high reproducibility and yield and b) enabling new optical design concepts that bring better display resolution, lower costs and energy savings. This differential value supports the effective market introduction of TOLAE based highly competitive products.
OptIntegral enables a wide choice of materials and options in process design to put the technological advances at the service of the cost, performance and time-to-market requirements of the novel displays.
The workplan sets and consolidates the value chain by the demonstration platform that links all actors, from LED suppliers to displays users. This allows to respond to market demands and to capture the user feedback on the effectiveness of the displays to communicate information and to meta-communicate attitudes towards the advertiser brand.
Three display manufacturers that are currently manufacturing and selling LED displays in EU will enlarge their portfolio by setting up pilot manufacturing lines and co-developing demonstrators adapted to their customers needs. This is achieved during the project with the goal to be on the market 1 year after the end of the project as a result of OptIntegral business case.";6675208,75;5675336,87;H2020-ICT-2014-1;IA;FUNDACIO EURECAT;ES;"NEONELEKTRO OY;Megatex Commerce Ltd.;ASOCIACION ESPANOLA DE NORMALIZACION;LUMYCOMP DESIGN LTD;UNIVERSITY OF BATH;HOLOGRAFIKA HOLOGRAMELOALLITO FEJLESZTO ES FORGALMAZO KFT;SIMULACIONS OPTIQUES SL;TEKNOLOGIAN TUTKIMUSKESKUS VTT;Teknologian tutkimuskeskus VTT Oy";"FI;BG;ES;UK;HU"; 194202;644399;MONROE;SIGNED;H2020-EU.2.1.1.3.;ICT-11-2014;H2020;Measuring Mobile Broadband Networks in Europe;1/03/2015;31/07/2018;;"There is a strong need for objective data about stability and performance of Mobile Broadband (MBB) networks, and for tools to rigorously and scientifically assess their performance. In particular, it is important to measure and understand the quality as experienced by the end user. Such information is very valuable for many parties including operators, regulators and policy makers, consumers and society at large, businesses whose services depend on MBB networks, researchers and innovators.

MONROE proposes to design, build and operate an open, European-scale, and flexible platform with multi-homing capabilities to run experiments on operational 3G/4G Mobile Broadband networks. One of the main objectives of MONROE is to use the platform for the identification of key MBB performance parameters, thus enabling accurate, realistic and meaningful monitoring and assessment of the performance of MBB networks. MONROE also provides WIFI connectivity mimicking multi-homing in smartphones with both MBB and WiFi interfaces, to allow experimenting on different access technologies as well as explore new ways of combining them to increase performance and robustness. The users of the platform are in the core of the MONROE project. First, following the FIREs philosophy, MONROE offers a user-oriented closed-loop system design in which the experimental platform is open to external users, and where users are incorporated early on in the experimental design process. Second, MONROE will provide Experiments as a Service (EaaS), thus lowering the barrier for using the platform to external experimenters and users, by providing well-documented tools and adjustable, flexible, high-level scripts to execute experiments, collect results, and analyze data. Interoperability with existing FIRE and FP7 measurement platforms, jointly with the MONROE's effort to develop business and funding models, will guarantee sustainability and usefulness of the platform.";6542418,75;6542418,75;H2020-ICT-2014-1;RIA;SIMULA RESEARCH LABORATORY AS;NO;"TELENOR ASA;CELERWAY COMMUNICATION AS;NEXTWORKS;NETTET SVERIGE AB;POLITECNICO DI TORINO;KARLSTADS UNIVERSITET;FUNDACION IMDEA NETWORKS";"NO;IT;SE;ES"; 194342;645651;MAPS-LED;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Multidisciplinary Approach to Plan Smart Specialisation Strategies for Local Economic Development;1/04/2015;31/03/2019;;"The joint Exchange programme is based on a research proposal finalized to examine how smart specialization strategies (S3) to regenerate local economic areas can be implemented, according to the new agenda of Europe 2020. This can be largely achieved by incorporating a place-based dimension. The main aim is to identify and prescribe the implementation S3 in terms of spatial, social and environmental factors. The programme will map out local needs and opportunities in a variety of contexts which could drive regional policy interventions. The resulting S3 will not only emphasize Key Enable Technologies, but will also empower the local innovation process. Elements gained from the preceding CLUDs project such as tacit knowledge, embedded social networks, and innovative milieu will ensure that the proposed S3 for each area is successful. The proposal intends to apply a Multidisciplinary Approach to Plan Smart Specialization Strategies in a prospective to enhance Local Economic Development (MAPS-LED). The MAPS-LED place-based framework will include two important drivers: 1. Cluster policy, 2. Innovative milieu in terms of the local value chains based on the urban-rural linkages The MAPS-LED project will be built in order to connect three important key-factors: Governance; Localization; Territorial network. The S3 in a MAPS-LED perspective will be visualized through appropriate designated areas, overcoming the constraints determined by the locally-bounded concept of the district through the rationale of the networks and flows activated by governance dynamics. The proposal exploits and moves forward the findings of the CLUDs project (research network of four EU and two US universities) funded by IRSES 2010, by expanding the concept of social and environmental added value embedded in some innovative urban regeneration approaches to the larger regional context. The result will be to build on the strong existing CLUDs research network and its Int'l Doctorate URED.";1512000;1512000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA DEGLI STUDI MEDITERRANEA DI REGGIO CALABRIA;IT;"AALTO-KORKEAKOULUSAATIO;THE UNIVERSITY OF SALFORD;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA";"FI;UK;IT"; 194104;643796;openMedicine;SIGNED;H2020-EU.3.1.;PHC-34-2014;H2020;openMedicine;1/01/2015;31/12/2016;;"The CSA will enhance the safety of cross-border healthcare through interoperable ePrescriptions. epSOS solved the message transfer problem, but encountered 2 serious delivery problems: the univocal identification of medicinal products (MPs) dispensed abroad, and substitution challenges.
Global SDOs (WHO, HL7, IHTSDO, ISO/CEN, GS1), EU regulatory agencies (EMA), MS Competent Authorities, major stakeholders (industry, health professionals, patients) harmonise their related efforts to deliver
common data models - expanding upon epSOS and existing standards (ISO/IDMP) - for prescribed MPs
a common meta-vocabulary for unambiguous definition, description, and identification of MPs
rules to harmonise practices of therapeutic and economic substitution
a roadmap for post-project actions and implementations
policy recommendations for the EU-USA road mapping process (MoU)
Work will link to related research & innovation activities of SDOs, epSOS, policy and regulatory processes (eHealth Network), the three other PHC34 projects.
WP1 develops a concise conceptual framework, including use case scenarios where the identification of a MP is an issue, including pharmacological and pharmacokinetic attributes, clinical indications and risks. WPs 2 address the identification and description of the pharmaceutical products, considering implementability as essential. WP3 investigates the situation in MSs with respect to substitution, and explores options for substitution. Each track develops a set of concrete solutions and road map recommendations, validated by experts in F2F meetings and workshops in WP4. Fostering exploitation by MS regulatory agencies and communication of results is the duty of WP5.
The project involves national competent authorities, SDOs and stakeholders not part of the core team at an early stage to assure the practicability, acceptance and trust in the solutions developed.
The CSA lasts 2 years involving 8 beneficiaries and about 25 expert organisations.";997938;997938;H2020-PHC-2014-single-stage;CSA;EMPIRICA GESELLSCHAFT FUER KOMMUNIKATIONS- UND TECHNOLOGIE FORSCHUNG MBH;DE;"HL7 INTERNATIONAL FONDATION;Custodix NV;STICHTING NEDERLANDS NORMALISATIE - INSTITUUT;HEALTH PRODUCTS REGULATORY AUTHORITY;INSTYTUT LOGISTYKI I MAGAZYNOWANIA;REGIONE LOMBARDIA;Agencia Espaola de Medicamentos y Productos Sanitarios";"BE;NL;IE;PL;IT;ES"; 194125;643990;POINT;SIGNED;H2020-EU.2.1.1.3.;ICT-05-2014;H2020;POINT: iP Over IcN - the betTer ip;1/01/2015;31/12/2017;;"The goal of POINT is to develop technology, innovations, and business value chains for commercially viable IP-over-ICN deployment, based on the hypothesis that many current IP-based applications can run better on an ICN-based network than on current IP networks.

To achieve this, we will first define a set of Key Performance Indicators (KPIs) to specify what exactly 'better' means. Then, we will specify a communication platform based on the ICN prototype developed in FP7 PURSUIT and develop a set of abstractions to enable current IP, TCP, HTTP and CoAP based applications to run on our platform, complemented by new resource coordination mechanisms to improve the performance of the network.

We will implement our platform as an operational prototype and validate it against the KPIs in a testbed as well as run a real-world field trial in an operator's production network with real customers. We will openly publish our design and all relevant data needed to deploy and improve our prototype, which in turn will be released as open source code. We will also undertake a wide range of dissemination activities to establish POINT as a key driver in the ICN community.

The POINT platform will provide new business opportunities for systems vendors, operators and service providers, including SMEs and we will evaluate the commercial viability of our solution and develop migration scenarios for operators wishing to deploy ICN in production networks. The consortium has all the experience and competencies needed to cover the entire chain from an idea and research prototype to a working platform ready for production use. In addition to academic partners, POINT includes a technology company, a telecom vendor, an ISP, a content provider, and a cooperative which will enable POINT to have an impact on the industry.";3494888;3494888;H2020-ICT-2014-1;RIA;AALTO-KORKEAKOULUSAATIO;FI;"PRIMETEL PLC;INTERDIGITAL EUROPE LTD;UNIVERSITY OF ESSEX;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;INTRACOM SA TELECOM SOLUTIONS;CTVC Ltd;ELL-I AVOIMEN LAHDEKOODIN OSUUSKUNTA;ATHENS UNIVERSITY OF ECONOMICS AND BUSINESS - RESEARCH CENTER";"CY;UK;DE;EL;FI"; 194187;644313;SWEEPER;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Sweet Pepper Harvesting Robot;1/02/2015;31/01/2018;;"In modern greenhouses there is a high demand to automate labour. The availability of a skilled workforce that accepts repetitive tasks in harsh greenhouse climate conditions is decreasing rapidly. The resulting increase in labour costs and reduced capacity puts major pressure on the competitiveness of the European greenhouse sector. Present robotization of this labour has entered an high level of technological readiness. However, a gap remains which halts the transition from science to economic and societal impact; the so called Technological Innovation Gap. In the EU-FP7-project CROPS extensive research has been performed on agricultural robotics. One of the applications was a sweet pepper harvesting robot. It was shown that such a robot is economically and technically viable. The proven hardware and software modules (TRL:6) developed in CROPS will be used as the groundwork. The successful CROPS software modules based on the Robotic-Operating-System (ROS) will be maintained and expanded in SWEEPER. Also the gripper end-effector will be retained. This patent pending module is able to grasp the sweet pepper without the need of an accurate measurement of the position and orientation of the fruit. From the CROPS project, also gained knowledge will directly be put to benefit. In several experiments, it turned out that different growers use different cropping systems ranging in crop density. In SWEEPER, the cropping system itself will be optimized to facilitate robotic harvesting. In CROPS it was concluded that instead of a 9DOF, a 4DOF robot arm is sufficient , greatly reducing costs. To improve the level of robotic cognitive abilities, plant models will be applied to approximate location of sweet peppers. This model-based vision will increase and speed up fruit detection. Based on the insights of CROPS, sensors will be placed onto the gripper only. Also a LightField sensor will be introduced which is able to record both colour and 3D information simultaneously.";4457035;4028311,5;H2020-ICT-2014-1;IA;STICHTING WAGENINGEN RESEARCH;NL;"BEN-GURION UNIVERSITY OF THE NEGEV;PROEFSTATION VOOR DE GROENTETEELT;IRMATO INDUSTRIAL SOLUTIONS VEGHEL B.V.;UMEA UNIVERSITET;DE TUINDERSHOEK BV";"IL;BE;NL;SE"; 194161;644178;CHOReVOLUTION;SIGNED;H2020-EU.2.1.1.3.;ICT-09-2014;H2020;Automated Synthesis of Dynamic and Secured Choreographies for the Future internet;1/01/2015;31/12/2017;;"The Future Internet (FI) represents an age of unprecedented opportunities for social, economic, and business growth thanks to the global scale connectivity of the virtual as well as of the physical world. This indeed opens up a wealth of innovative and revolutionary real-life scenarios, as for instance illustrated by the smarter cities perspectives where envisioned scenarios significantly ease daily human activities and give support for the growth of new markets and employment opportunities. However, leveraging the FI for the development of innovative software applications remain a challenging task even though major enablers are readily available by ways of service-oriented and cloud computing. It is in particular our vision that enabling the choreography of FI services shall play a significant role in the provisioning of innovative applications. However, existing choreography-based service composition approaches are rather static and are poorly suited to the need of the FI that is a highly dynamic networking environment, further bringing together highly heterogeneous services ranging from Thing- to Business-based services that span different security domains. As a result, the technology is not mature enough for market take-up. CHOReVOLUTION elevates the Readiness Level of existing choreography technologies in order to drop the dynamism and cross-organization security barriers via the automated synthesis of dynamic and secured choreographies in the FI. To meet its objectives, CHOReVOLUTION undertakes both research and innovation tasks. The former concentrates on choreography modelling, synthesis, adaptation, service bus, security, and cloud; the latter focus on industrial validation, development support and integration platform, and the establishment of a CHOReVOLUTION community and market take-up. Last but not least CHOReVOLUTION outcomes are assessed by experimenting with new applications in the field of Intelligent Transportation Systems.";3057549;3057549;H2020-ICT-2014-1;RIA;THALES COMMUNICATIONS & SECURITY SAS;FR;"CEFRIEL - SOCIETA CONSORTILE A RESPONSABILITA LIMITATA;TIRASA SRL;SOFTECO SISMAT SRL;OW2 CONSORTIUM ASSOCIATION;UNIVERSITA DEGLI STUDI DELL'AQUILA;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;VIKTORIA SWEDISH ICT AB";"IT;FR;SE"; 194219;644583;LT_Observatory;SIGNED;H2020-EU.2.1.1.4.;ICT-17-2014;H2020;LT_OBSERVATORY - OBSERVATORY FOR LR and MT in EUROPE;1/01/2015;31/12/2016;;"The European Digital Single Market, one of the main goals of Europe 2020, is still fragmented due to language barriers. European society is multilingual, the diversity of its cultural heritage is an opportunity, but hampers transborder eCommerce, social communication and exchange of (cultural) content. Languages without sufficient technological support will become marginalised. These barriers must be overcome by language technology (LT) like Machine Translation (MT) solutions, a need recognized by the future Connecting Europe Facility (CEF).
To support these endeavours to reach an online EU internal market free of language barriers, it is necessary to join, benchmark the quality and facilitate the access to language resources. With this in mind LT Observatory's aims are:
- Create a language resource repository stemming from national public sector parallel corpora (taking into account existing ones); check these resources with regard to their quality and benchmark them for most possible reliability and, interoperability including legal and standardization issues.
- Identify national and regional funding sources, including Regional and Structural Funds
- Continue with a LT News Observatory, started in the LT COMPASS project.
- Foster cooperation across stakeholders through targeted dialogue events.
- Create a roadmap for future needs to improve the quality of MT and for a high coverage of languages within the Digital Single Market.
Based on achievements of former initiatives (e.g. FLaReNet, META), the LT Observatory will be implemented by a team with all the expertise needed:
ZABALA (EU project management and with Europe-wide outreach), EMF (ICT Association with experience in outreach/social media, and funding, e.g. ESIF and combined funding), LT Innovate (the Forum of European LT vendors), CLARIN ERIC (LT resources and infrastructure, including a Virtual Language Observatory), and University of Vienna/InfoTerm, international information centre for terminology.";982565;982563;H2020-ICT-2014-1;CSA;ZABALA INNOVATION CONSULTING, S.A.;ES;"LT-INNOVATE;EUROPEAN MULTIMEDIA FORUM LTD;UNIVERSITAT WIEN;CLARIN ERIC";"UK;AT;NL"; 194172;644210;ePlus Ecosystem;SIGNED;H2020-EU.2.1.1.3.;ICT-13-2014;H2020;Fostering Web Entrepreneurship in Europe: e-talent, e-mentoring, e-services and e-capital for e-entrepreneurs;1/01/2015;30/06/2017;;"The ePlus ecosystem project will develop and deploy an online and onsite environment, building on and interconnecting existing ecosystems, hubs and initiatives, in order to setup a runway for web entrepreneurs to start and scaleup a business in Europe and grow internationally. This European ecosystem will help web-entrepreneurs to develop and scale up their ideas and businesses, from a business international validation phase, to internationalization, access to finance and to business growth, thus complementing the service offer currently made available at local ecosystems level. The ePlus project will meet the objectives stated in the workprogramme in terms of accelerating web entrepreneurship in Europe, and offer a unique new platform that answers to the need for new services expressed in the Startup Manifesto. It will provide the nurturing to help web-entrepreneurs go global, through a unique combination of talents, tools and services of an European scale in all key elements required to create great companies: team, concept, technology, and capital. This will be done through the following elements:
- Putting in motion a true pan-european web-entrepreneurship ecosystem by setting up the initial backbone made of the interconnection between the booming regional ecosystems of Lisbon, Nice and Baden-Wrttemberg, combining and intertwining current services and opportunities and making room for more local ecosystems to join in;
- Untap on Europes unique mass of \ 50,000 skilled and mobile researchers generated by institutions such as the Marie Curie Actions in order to reinforce the web-entrepreneurs teams skills and technology grasp;
- Guide web-entrepreneurs into global business concepts through a European mentoring scheme, building on the best regional and national programmes available;
- Facilitate access to some of the best services from the best service providers in Europe to promote web-entrepreneurs growth;
- Ensure access to capital either in early stage or crowdfunding form.";2598794,64;1995518,75;H2020-ICT-2014-1;IA;INOVAMAIS - SERVICOS DE CONSULTADORIA EM INOVACAO TECNOLOGICA S.A.;PT;"INTRASOFT INTERNATIONAL SA;EUROPE UNLIMITED S.A.;European Business Angel Network;EUROPEAN CROWDFUNFIND NETWORK;CAMARA MUNICIPAL DE LISBOA;BWCON GMBH;CAPGEMINI NEDERLAND BV;HUGIN&MUNIN SL;CHAMBRE DE COMMERCE ET D'INDUSTRIE NICE COTE D'AZUR";"LU;BE;PT;DE;NL;ES;FR"; 194259;644902;LUMENTILE;SIGNED;H2020-EU.2.1.1.1.;ICT-03-2014;H2020;LUMinous ElectroNic TILE;1/03/2015;28/02/2018;;"LUMENTILE originates from an idea of disruptive innovation, where the joint use of new technologies creates added value and new functionalities for traditional materials, thus turning the classical ceramic tile into a multifunctional electronic luminous tile realized by large area and organic electronics. LUMENTILE can be also considered as design-driven innovation, where we give a different meaning to the use of light driven by the design, by empowering it to be used as a radical different designed element for architecture, as a skin integrated element for interior design, lighting or advertising purposes.
The demand for aesthetically integrated and creative construction elements is steadily increasing in many areas of business and industries. A growing number of designers, architects and industrial manufacturers across the world share a common interest in having new elements capable to create surfaces or coverings as creative and multifunctional solutions.
LUMENTILE aims, on one side, to fill the gap between a simple construction element and a luminous surface element, and gooes far beyond, by developing a cutting-edge technologic module (the luminous electronic tile) that is capable of displaying lights, colors and images that can be used as a chameleonic display to be employed as a skin for horizontal (floor) or vertical (wall) applications. The final product will be an on-the-fly high energy efficient device that can be considered as a sustainable and competitive lighting element. On the other hand, the possibility of adding other sensors internally to the electronic tile enables it to increase the above mentioned properties (such as the detection of people walking onto it) and also to empower other creative or multifunction purposes.
This project will address the above-mentioned challenges by exploring and developing new materials and integrated systems, manufacturing processes and business scenarios in luminous designed tiles and architecture.";2969176,25;2470113,75;H2020-ICT-2014-1;RIA;UNIVERSITA DEGLI STUDI DI PAVIA;IT;"JULIGHT SRL;STUDIO ITINERANTE ARQUITECTURA SL;KNOWLEDGE INNOVATION MARKET S.L.;ECLEXYS SAGL;KERAPLAN SRL;TEKNOLOGIAN TUTKIMUSKESKUS VTT;Teknologian tutkimuskeskus VTT Oy";"IT;ES;CH;FI"; 194418;646142;NanoPilot;SIGNED;H2020-EU.2.1.2.1.;NMP-08-2014;H2020;A Pilot Plant for the Production of Polymer based Nanopharmaceuticals in Compliance with GMP;1/01/2015;31/12/2018;;"The aim of NanoPilot will be to set-up a flexible and adaptable pilot plant operating under GMP for the production of small batches of polymer-based nanopharmaceuticals, which exhibit significant potential in the field of drug-delivery particularly for the design of second-generation nanopharmaceuticals.
Three different processes will be established for the production of three different nanopharmaceuticals selected on the basis of their TRL and positive commercial evaluation: a) topical treatment of ocular pain associated with dry eye syndrome containing short interfering RNA and lactic acid, b) A resuspendable HIV nanovaccine for intranasal vaccination containing 12 peptides in its formulation. c) Hyaluronan based hollow spheres intended for intravesical instillation, for the treatment of interstitial cystitis/painful bladder syndrome.
State of the art production processes including micro reactors and highly advanced characterization techniques will ensure the quality of the nanodrugs. Existing laboratories suitable for large-scale production of biologics in compliance with GMP, and owned by the coordinator, will be adapted and certified within this project to enable the operability of the pilot plant.
NanoPilot consists of nine complementary partners composed by 1 Industry and 2 academia developers of the nanosystems to scale-up. A research Institute expert in nanoparticle characterizacion and already operating in compliance with Good laboratory practices. An SME and an Industry that will develop ad-hoc continuous flow reactors for the optimization of two of the three processes. A consultancy (SME) expert in Quality system implementation and laboratory information management systems. A second consultancy (SME) in charge of the business plan, that will also help the coordinator in dissemination and exploitation activities. Finally, a research centre with a recorded track in nanomedicine, already operating under ISO 9001, and will be in charge of the pilot plant.";6283988,75;6283988,75;H2020-NMP-PILOTS-2014;RIA;FUNDACION CIDETEC;ES;"CHEMTRIX BV;MICRONIT GMBH;SPINVERSE INNOVATION MANAGEMENT OY;MEJORAN LAB AUTOMATION SL;NATIONAL UNIVERSITY OF IRELAND, GALWAY;SYLENTIS SAU;UNIVERSIDAD DE SANTIAGO DE COMPOSTELA;IX-FACTORY GMBH;ASSOCIATION POUR LE DEVELOPPEMENT DE L'ENSEIGNEMENT ET DES RECHERCHES AUPRES DES UNIVERSITES, DES CENTRES DE RECHERCHE ET DES ENTREPRISES D'AQUITAINE";"NL;DE;FI;ES;IE;FR"; 194204;644402;HimL;SIGNED;H2020-EU.2.1.1.4.;ICT-17-2014;H2020;Health in my Language;1/02/2015;31/01/2018;;To an ever-increasing extent, web-based services are providing a frontline for healthcare information in Europe. They help citizens find answers to their questions and help them understand and find the local services they need. However, due to the number of languages spoken in Europe, and the mobility of its population, there is a high demand for these services to be available in many languages. In order to satisfy this demand, we need to rely on automatic translation, as it is infeasible to manually translate into all languages requested. The aim of HimL is to use recent advances in machine translation to create and deploy a system for the automatic translation of public health information, with a special focus on meaning preservation. In particular, we will include recent work on domain adaptation, translation into morphological rich languages, terminology management, and semantically enhanced machine translation to build reliable machine translation for the health domain. The aim will be to create usable, reliable, fully automatic translation of public health information, initially testing with translation from English into Czech, Polish, Romanian and German. In the HimL project we will iterate cycles of incorporating improvements into the MT systems, with careful evaluation and user acceptance testing.;3071897,77;2949571,25;H2020-ICT-2014-1;IA;THE UNIVERSITY OF EDINBURGH;UK;"NHS 24 (SCOTLAND);UNIVERZITA KARLOVA;LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN;THE COCHRANE COLLABORATION;LINGEA SRO";"UK;CZ;DE"; 194324;645452;QT21;SIGNED;H2020-EU.2.1.1.4.;ICT-17-2014;H2020;QT21: Quality Translation 21;1/02/2015;31/01/2018;;A European Digital Single Market free of barriers, including language barriers, is a stated EU objective to be achieved by 2020. The findings of the META-NET Language White Papers show that currently only 3 of the EU-27 languages enjoy moderate to good support by our machine translation technologies, with either weak (at best fragmentary) or no support for the vast majority of the EU-27 languages. This lack is a key obstacle impeding the free flow of people, information and trade in the European Digital Single Market. Many of the languages not supported by our current technologies show common traits: they are morphologically complex, with free and diverse word order. Often there are not enough training resources and/or processing tools. Together this results in drastic drops in translation quality. The combined challenges of linguistic phenomena and resource scenarios have created a large and under-explored grey area in the language technology map of European languages. Combining support from key stakeholders, QT21 addresses this grey area developing (1) substantially improved statistical and machine-learning based translation models for challenging languages and resource scenarios, (2) improved evaluation and continuous learning from mistakes, guided by a systematic analysis of quality barriers, informed by human translators, (3) all with a strong focus on scalability, to ensure that learning and decoding with these models is efficient and that reliance on data (annotated or not) is minimised. To continuously measure progress, and to provide a platform for sharing and collaboration (QT21 internally and beyond), the project revolves around a series of Shared Tasks, for maximum impact co-organised with WMT. To support early technology transfer, QT21 proposes a Technology Bridge linking ICT-17(a) and (b) projects and opening up the possibility of showing technical feasibility of early research outputs in near to operational environments.;3997428;3977428;H2020-ICT-2014-1;RIA;DEUTSCHES FORSCHUNGSZENTRUM FUER KUENSTLICHE INTELLIGENZ GMBH;DE;"DUBLIN CITY UNIVERSITY;THE UNIVERSITY OF EDINBURGH;UNIVERZITA KARLOVA;TAUS B.V.;RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN;Hong Kong University of Science and Technology;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;KARLSRUHER INSTITUT FUER TECHNOLOGIE;TEXT & FORM GMBH;THE UNIVERSITY OF SHEFFIELD;TILDE SIA;FONDAZIONE BRUNO KESSLER;UNIVERSITEIT VAN AMSTERDAM";"IE;UK;CZ;NL;DE;HK;FR;LV;IT"; 194146;644055;ALIGNED;SIGNED;H2020-EU.2.1.1.3.;ICT-09-2014;H2020;Aligned, Quality-centric Software and Data Engineering;1/02/2015;31/01/2018;;"The rapid growth of web data creates demand for software engineering methods which can build and maintain applications that extract, process and publish web data. However, converting Big Data sources into high-quality, structured knowledge for use in business processes is usually considered data engineering. ALIGNED will develop models, methods and tools for engineering information systems based on co-evolving software and web data. Tools for model-driven software evolution based on Linked Data sources, runtime data quality analytics, human data curation and process integration will aid more efficient governance, increased agility and higher productivity.

The opportunities for web data have recently led to intense research and innovation, but most efforts are siloed in the software or data spaces. Past integration of data and software engineering used formal ontologies rather than Linked Data. ALIGNED will provide lightweight methods for European data and software engineering industries to exploit the new opportunities in web data. Information companies like Wolters Kluwer need better ways to extract web data and build applications on top of it. Public bodies like the UK National Health Service (NHS) need evolving systems for data collection and re-use. Web data publishers like DBpedia need new methods to improve data quality. Scientific publications, industry workshops, training programs, open source tools and engaging the OMG, W3C and ISO standards bodies will transfer ALIGNED outputs.

ALIGNED combines world class researchers in model driven software engineering (Oxford are transforming NHS systems), Linked Data quality (Leipzig and Trinity College have published foundational papers) and web systems (Leipzig are co-creators of DBpedia) with innovative enterprises (Wolters Kluwer have Linked Data in production systems, Semantic Web Company lead the world in enterprise Linked Data) and pioneering expert-curated data publishers (Oxford Anthropology and Posnan).";3999934;3999934;H2020-ICT-2014-1;RIA;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN;IE;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;SEMANTIC WEB COMPANY GMBH;UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU;Universitt Leipzig;WOLTERS KLUWER DEUTSCHLAND GMBH";"UK;AT;PL;DE"; 194157;644122;BEBA;SIGNED;H2020-EU.2.1.1.3.;ICT-05-2014;H2020;Behavioral Based Forwarding;1/01/2015;31/03/2017;;"BEBA challenges a very ambitious goal: can we deploy wire-speed-reactive control/processing tasks inside the network switches, while retaining i) centralized control of their specification/operation, ii) high performance and scalability, and - crucial for real world adoption - iii) platform independency, i.e., consistency with the vendors need for closed platforms?
BEBAs answer revolves around the identification of a programming abstraction in the form of eXtended Finite State Machines (XFSMs). Via platform-agnostic XFSM programs, operators and enterprises will deploy not only static packet forwarding/processing rules (as in current OpenFlow devices), but will be able to specify and wire-speed enforce how such rules shall dynamically adapt to the time-varying flow and traffic behavior, i.e. in reaction to packet-level events, internal statistics changes, link/queue conditions, etc.
BEBA holds the promise for future-proof, efficient, and easy to administer network devices capable to be repurposed so as to meet emerging needs. Indeed, BEBAs approach, extended with node-level processing primitives made usable through our programming abstraction, brings about key benefits in the ability to i) software-define middlebox-type network functions well beyond static packet forwarding, with specific projects attention to the monitoring and network security applications domains, and in the possibility to ii) address the current shortcomings revolving around the high latency and large overhead of centralized network control tasks.
Finally, BEBA commits to a concrete and pragmatic innovation strategy. Short-time impact and standardization will be attempted by i) casting (part of) the BEBA approach as OpenFlows extensions; ii) making its implementation feasible over merchant-silicon chipsets currently found in commodity switches, and iii) releasing an open source virtual BEBA switch for the benefits of the Network Functions Virtualization community.";2549976,25;2545976;H2020-ICT-2014-1;RIA;CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI;IT;"THALES COMMUNICATIONS & SECURITY SAS;NEC EUROPE LTD;KUNGLIGA TEKNISKA HOEGSKOLAN;6WIND;CESNET ZAJMOVE SDRUZENI PRAVNICKYCH OSOB";"FR;UK;SE;CZ"; 194244;644780;MAMEM;SIGNED;H2020-EU.2.1.1.4.;ICT-22-2014;H2020;Multimedia Authoring and Management using your Eyes and Mind;1/05/2015;30/04/2018;;Loss of the voluntary muscular control while preserving cognitive functions is a common symptom of neuromuscular disorders leading to a variety of functional deficits, including the ability to operate software tools that require the use of conventional interfaces like mouse, key-board, or touch-screens. As a result, the affected individuals are marginalized and unable to keep up with the rest of the society in a digitized world. MAMEM's goal is to integrate these people back into society by increasing their potential for communication and exchange in leisure (e.g. social networks) and non-leisure context (e.g. workplace). In this direction, MAMEM delivers the technology to enable interface channels that can be controlled through eye-movements and mental commands. This is accomplished by extending the core API of current operating systems with advanced function calls, appropriate for accessing the signals captured by an eye-tracker, an EEG-recorder and bio-measurement sensors. Then, pattern recognition and tracking algorithms are employed to jointly translate these signals into meaningful control and enable a set of novel paradigms for multimodal interaction. These paradigms will allow for low- (e.g., move a mouse), meso- (e.g., tick a box) and high-level (e.g., select n-out-of-m items) control of interface applications through eyes and mind. A set of persuasive design principles together with profiles modeling the users (dis-)abilities will be also employed for designing adapted interfaces for disabled. MAMEM will engage three different cohorts of disabled (i.e. Parkinson's disease, muscular disorders, and tetraplegia) that will be asked to test a set of prototype applications dealing with multimedia authoring and management. MAMEM's final objective is to assess the impact of this technology in making these people more socially integrated by, for instance, becoming more active in sharing content through social networks and communicating with their friends and family;2704375;2704375;H2020-ICT-2014-1;RIA;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;EL;"ARISTOTELIO PANEPISTIMIO THESSALONIKIS;SENSOMOTORIC INSTRUMENTS GESELLSCHAFT FUR INNOVATIVE SENSORIK MBH;EB NEURO SPA;MDA ELLAS SOMATEIO GIA TI FRONTIDATON ATOMON ME NEVROMYIKES PATHISEIS;UNIVERSITAET KOBLENZ-LANDAU;TECHNISCHE UNIVERSITEIT EINDHOVEN;Sheba Medical Center";"EL;DE;IT;NL;IL"; 194106;643808;MARIO;SIGNED;H2020-EU.3.1.;PHC-19-2014;H2020;Managing active and healthy aging with use of caring service robots;1/02/2015;31/01/2018;;"MARIO addresses the difficult challenges of loneliness, isolation and dementia in older persons through innovative and multi-faceted inventions delivered by service robots. The effects of these conditions are severe and life-limiting. They burden individuals and societal support systems. Human intervention is costly but the severity can be prevented and/or mitigated by simple changes in self-perception and brain stimulation mediated by robots.
The proposal is coordinated by the nursing unit of NUI, involves managers of the City of Stockport developing social care and community support programs to older persons, and also involves an important hospital in Italy pushing research boundaries in comprehensive geriatric assessment. Pilot activities and interaction with caregivers, older persons and stakeholders (within a standards based medical assessment methodology) is present from beginning to finish and provides a user led design ethos.
The proposal brings together the well-known Kompai platform and commercial footprint of ROBOSOFT, control expertise of RURobots, advances from the computer laboratory at CNR, and an innovative robot application development platform by Ortellio. Dedicated telecommunication (CNET) and exploitation experts (R2M) widen technical and market outreach potential. From this unique combination, clear advances are made in the use of semantic data analytics, personal interaction, and unique applications tailored to better connect older persons to their care providers, community, own social circle and also to their personal interests. Each objective is developed with a focus on loneliness, isolation and dementia.
The impact centres on deep progress toward EU scientific and market leadership in service robots and a user driven solution for this major societal challenge. The competitive advantage is the ability to treat tough challenges appropriately. The path to market deployment by bringing Mario solutions to end users is clearly developed.";3994857;3994857;H2020-PHC-2014-single-stage;RIA;NATIONAL UNIVERSITY OF IRELAND, GALWAY;IE;"ROBOSOFT Services Robots;STOCKPORT METROPOLITAN BOROUGH COUNCIL;MILIOTI LOUKIA TOU ANASTASIOS;ORTELIO LTD;R.U.Robots Limited;CONSIGLIO NAZIONALE DELLE RICERCHE;UNIVERSITAT PASSAU;FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA;R2M SOLUTION SRL";"FR;UK;EL;IT;DE"; 194403;645900;SYNAMERA;SIGNED;H2020-EU.2.1.3.;NMP-36-2014;H2020;Synergies in Nanotechnologies, Materials and Production in the European Research Area;1/05/2015;30/04/2017;;"This proposal for a Coordination Action aims at improving visibility for essential stakeholders, most notably national/regional programming and funding authorities, on programming synergetic actions between the European Union and member states in the NMP Program. This shall be done by organising a forum and collecting road maps focused in particular on the use of the new ERANET instrument in the NMP area.

In doing so, the CSA shall acknowledge that the NMP program has an important role in translating result from flagships towards industrial application and in facilitating key enabling technologies towards the Grand Societal Challenges. It shall also take into account the methodology of technology readiness levels is leading the programmation of the NMP work program. Programming should also acknowledge that industrial leadership, for SMEs in particular is an important objective. This objective should result in a road-map with the aim to increase visibility on themes to program.

In exploiting synergies, the new ERANET Instrument is an important tool. In order to operationalize it in Horizon2020 visibility should be improved on best practices in using the ERANET under FP7 as well collecting a database on projects funded through it. This shall give input to a forum to discuss future opportunities and identify critical mass of funding agencies willing to support it.

Synergies shall often require alignment of European, National and Regional funding. In fact operational programs under ERDF demand these synergies. In NMP many topics demand an alignment of proposals with regional Smart Specialisation Strategies. How these synergies can be organised is an explicit objective, with the aim, to enlarge the number of funding agencies (national or regional) able to use it. Therefore particular attention in this project shall be given to reach out to as many regions as possible.";496221,25;496221,25;H2020-NMP-CSA-2014;CSA;REGION NORD-PAS-DE-CALAIS ET PICARDIE;FR;"OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;FUNDACION PARA EL CONOCIMIENTO MADRIMASD;MATIKEM;SERVICE PUBLIC DE WALLONIE;KARLSRUHER INSTITUT FUER TECHNOLOGIE;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;STICHTING MATERIALS INNOVATION INSTITUTE (M2I)*;Ministrstvo za izobrazevanje, znanost in sport;ASOCIACION AGENCIA VASCA DE LA INNOVACION-BERRIKUNTZAREN EUSKAL AGENTZIA;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"AT;ES;FR;BE;DE;RO;NL;SI;PT"; 194131;644014;PICSE;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;Procurement Innovation for Cloud Services in Europe;1/10/2014;31/03/2016;;"The PICSE Procurers Platform will give access to a unique repository of information supporting the move from outright purchase to pay-per-usage made possible by the arrival of cloud computing. It builds on the Helix Nebula collaboration between supply and demand of which the three PICSE partners are key members, including the H-N coordinator, CERN. It addresses the fragmented landscape of inconsistent technical approaches and disjointed managerial structures that prevent delivery of a production-quality cloud computing e-infrastructure.

PICSE will engage with cloud service providers, their customers and procurement professionals over a crucial period as Europes Cloud Strategy comes to fruition and several large multinational procurements (including PPIs and PCPs) take place. The project will provide a focal point avoiding duplication of efforts to identify, analyse, publicise and harmonise opportunities for shared procurement, including a direct response to the ECP Trusted Cloud Europe science use case, addressing cross-border procurement.

PICSE will resolve key financial and legal constraints impacting business development and procurement and provide a range of best practices that address those barriers from both private and public sectors, including the research domain, in and beyond Europe. It will set out a realistic roadmap of future procurement based on the levels of ambition for adoption of cloud services over the next five years. This reflects the European Cloud Computing Strategy which calls for a framework of standards to give procurers confidence that they have met their compliance obligations and that they are getting an appropriate solution to meet their needs.";499875;499875;H2020-ICT-2014-1;CSA;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH;CH;"CLOUD SECURITY ALLIANCE (EUROPE) LBG;TRUST-IT SERVICES LIMITED";UK; 194310;645342;reTHINK;SIGNED;H2020-EU.2.1.1.3.;ICT-05-2014;H2020;Trustful hyper-linked entities in dynamic networks;1/01/2015;30/06/2017;;"The Internet (r)evolution has changed traditional business and forces it to reinvent itself. Traditional operator-enabled services are losing on their importance due to a variety of new communication services, like chat and social networks, which complement or supersede traditional ones like voice telephony. Technical progress has minimized the need for access-controlled communication services and is moving instead to context based communication, which is presumably available at only marginal or no additional cost.
However, unlike traditional telecommunication services, that enable universal communication, Internet communication tools are characterized by their walled garden approach, where users can only communicate with users of the same application and are not free to change application without losing their data or contacts.
The main goal of the reTHINK project is to design and prototype a new, non telecom centric, but Web-centric P2P Service Architecture enabling dynamic trusted relationships among distributed applications called Hyperlinked Entities that support use-cases such as contextual and social communications, M2M/IoT and content oriented services. This project will enable any type of service delivery through specialized end-to-end network quality commitments, powered by specialized P2P and/or Cloud services (delivered as SaaS,PaaS or IaaS).
The major structural difference between the operators approach and the web companies is related to a recurring concept in the deployment of ICT solutions: full deperimeterisation of services. Operators today cannot directly compete at a global level because their services are not and cannot be provided outside of the deployed and owned network. The services operators provide are tightly coupled with the network's functionalities and its geographical extension.
The work is performed by a consortium of 3 global telecom operators, 2 SMEs, 2 Universities and 2 leading research institutes, coordinated by Eurescom.";4720331,25;4720331,25;H2020-ICT-2014-1;RIA;EURESCOM-EUROPEAN INSTITUTE FOR RESEARCH AND STRATEGIC STUDIES IN TELECOMMUNICATIONS GMBH;DE;"APIZEE;ALTICE LABS SA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;TECHNISCHE UNIVERSITAET BERLIN;INSTITUT MINES-TELECOM;DEUTSCHE TELEKOM AG;INESC ID - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA;ORANGE SA;QUOBIS NETWORKS SL";"FR;PT;DE;ES"; 194142;644047;INTO-CPS;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;INtegrated TOol chain for model-based design of CPSs;1/01/2015;31/12/2017;;"The aim of the INTO-CPS project is to create an integrated tool chain for comprehensive model-based design of Cyber-Physical Systems (CPSs). The tool chain will support the multidisciplinary, collaborative modelling of CPSs from requirements, through design, down to realisation in hardware and software. This will enable traceability at all stages of the development.
INTO-CPS will support the holistic modelling of CPSs, allowing system models to be built and analysed that would otherwise not be possible using standalone tools. We will integrate existing industry-strength tools with high Technology Readiness Levels (TRL 69) in their application domains. The solution will be based centrally around Functional Mockup Interface (FMI)-compatible co-simulation. The project focuses on the pragmatic integration of these tools, making extensions in areas where a need has been recognised. The tool chain will be underpinned by a well-founded semantic foundations that ensures the results of analysis can be trusted.
The tool chain will provide powerful analysis techniques for CPSs, including connection to SysML; generation and static checking of FMI interfaces; model checking; Hardware-in-the-Loop (HiL) and Software-in-the-Loop (SiL) simulation, supported by code generation. The tool chain will allow for both Test Automation (TA) and Design Space Exploration (DSE) of CPSs. The INTO-CPS technologies will be accompanied by a comprehensive set of method guidelines that describe how to adopt the INTO-CPS approach, lowering entry barriers for CPS development. The tool chain will be tested with case studies in railways, agriculture, building and automotive.
The consortium has 4 academic and 7 industrial partners. The industrial partners comprise both tool vendors and case study owners. The INTO-CPS technology will enable experimenting with design alternatives enabling radical innovation where the overall concept is right first time, even when hardware prototypes does not yet exists.";7956805,25;7956804,25;H2020-ICT-2014-1;RIA;AARHUS UNIVERSITET;DK;"UNITED TECHNOLOGIES RESEARCH CENTRE IRELAND, LIMITED;LINKOPINGS UNIVERSITET;CLEARSY SAS;TWT GMBH SCIENCE & INNOVATION;UNIVERSITY OF NEWCASTLE UPON TYNE;AGRO INTELLIGENCE APS;VERIFIED SYSTEMS INTERNATIONAL GMBH;SOFTEAM;University of York;KONGSKILDE INDUSTRIES AS;CONTROLLAB PRODUCTS B.V.";"IE;SE;FR;DE;UK;DK;NL"; 194110;643850;J-Age II;SIGNED;H2020-EU.3.1.;HCO-02-2014;H2020;Coordination Action for implementation and alignment activities of the Joint Programming Initiative (JPI) 'More Years Better Lives the Challenges and Opportunities of Demographic Change';1/03/2015;28/02/2018;;J-AGEII, the Coordination Action for implementation and alignment activities of the Joint Programming Initiative (JPI) 'More Years Better Lives the Challenges and Opportunities of Demographic Change', will support and foster the overall management of the JPI, update the Strategic Research Agenda and support implementation through joint activities between Member States. Furthermore, the work plan will include dissemination and information exchange with scientific and societal stakeholders, policy makers and research funders as well as an evaluation and monitoring exercise. Ultimately, the project and the JPI seek to stimulate the alignment of relevant national programmes and EU initiatives, strengthen the base of multi-disciplinary and holistic ageing research in Europe and to provide scientific evidence for policy responses to demographic change.;2028049;2028049;H2020-HCO-2014;CSA;ZORGONDERZOEK NEDERLAND ZON;NL;"INSTITUT NATIONAL D'ETUDES DEMOGRAPHIQUES;VDI/VDE INNOVATION + TECHNIK GMBH;INSTITUTO DE SALUD CARLOS III;ECONOMIC AND SOCIAL RESEARCH COUNCIL;FORSKINGSRADET FOR HALSA ARBETSLIVOCH VALFARD;TERVEYDEN JA HYVINVOINNIN LAITOS;CANADIAN INSTITUTES OF HEALTH RESEARCH;Universit Cattolica del Sacro Cuore";"FR;DE;ES;UK;SE;FI;CA;IT"; 194091;643692;SMART2D;SIGNED;H2020-EU.3.1.;HCO-05-2014;H2020;A people-centred approach through Self-Management and Reciprocal learning for the prevention and management of Type-2-Diabetes;1/01/2015;31/03/2019;http://ki.se/en/phs/smart2d;"Background:
Type 2 diabetes mellitus (T2DM) and pre-diabetes contribute increasingly to the global burden of disease with the health systems struggling to effectively manage prevention and control. This necessitates contextually appropriate, policy relevant solutions with high scale-up potential. The study is built on a consortium experienced in implementation and cross-cultural translation of disease prevention and management. We aim to strengthen capacity for T2DM care including prevention in high-risk population, through proven strategies like task shifting to community health workers, and expanding care networks through community-based peer support groups.

Methods:
A phased, participatory approach with built-in on-going policy dialogue will be used for implementing and testing a complex intervention in three countries representing low-, middle- and high-income settings: rural Uganda, urban South Africa and vulnerable immigrant populations in urban Sweden. These actions will follow an iterative process with modifications and improvements within and between the stages of formative research to implementation and evaluation. The testing will be conducted with a controlled design in two arms, a facility-only strategy vs. a combined facility and community strategy evaluated in terms of health systems, disease-related and equity outcomes.

Outcomes:
The study has a strong social innovations component that will leverage existing networks and platforms, to empower patients, their families and communities through the self-management approach. It will embed research into policy and practice from the beginning; and enable cross-lessons from other chronic conditions and reciprocal learning. It will re-introduce the essential but missing community component still existing in low- and middle-income countries back to the health system of a high-income country in a contextually appropriate form, which is relevant for Europe in tackling T2DM and other chronic conditions.";3344981,25;3344979;H2020-HCO-2014;RIA;KAROLINSKA INSTITUTET;SE;"ABSETZ SIRKKU PILVIKKI;PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE;UNIVERSITY OF THE WESTERN CAPE;MAKERERE UNIVERSITY;Uppsala universitet";"FI;BE;ZA;UG;SE"; 194186;644312;RAPID;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Heterogeneous Secure Multi-level Remote Acceleration Service for Low-Power Integrated Systems and Devices;1/01/2015;31/12/2017;;"Many low-power devices such as smartphones, tablets, notebooks as well as several other embedded systems can't always cope with the increased demand for processing power, memory and storage required by modern applications in gaming, vision, security, robotics, aerospace, etc. As a result, most such applications are only executed on high-end servers.

RAPID tackles this challenge by taking advantage of high-performance accelerators and high-bandwidth networks. Following our approach, compute or storage intensive tasks are seamlessly offloaded from the low-power devices to more powerful heterogeneous accelerators, supporting multiple virtual CPUs and GPUs. We propose, for the first time, a secure unified model where almost any device or infrastructure, ranging from smartphone, notebook, laptop and desktop to private and public cloud can operate as an accelerated entity and/or as an accelerator serving other less powerful devices in a secure way.

RAPID offers a registration mechanism, which permits the accelerated entities to automatically find and connect to nearby accelerators with the required resources. Next, a runtime system, running on each such accelerated entity, takes into account several parameters such as the local status, the environmental conditions, the task requirements, and the status of the accelerators it is connected to in order to decide whether local tasks (or incoming tasks if the entity also acts as an accelerator) should be executed locally or remotely. Novel scheduling algorithms, admission control policies, Service Level Agreements and license policies are employed to serve multiple accelerated applications efficiently on heterogeneous cloud infrastructures.

An easy-to-use task-based programming model will be defined, while a novel runtime will automatically offload and execute the tasks transparently to the programmer. Within the RAPID project the first public acceleration cloud service will become available and commercially exploitable.";2023800;2023800;H2020-ICT-2014-1;RIA;FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS;EL;"HERTA SECURITY SL;UNIVERSITA DEGLI STUDI DI NAPOLI PARTHENOPE;THE QUEEN'S UNIVERSITY OF BELFAST;SINGULARLOGIC ANONYMI ETAIREIA PLIROFORIAKON SYSTIMATON KAI EFARMOGON PLIROFORIKIS;ATOS SPAIN SA;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA";"ES;IT;UK;EL"; 194229;644663;RIFE;SIGNED;H2020-EU.2.1.1.3.;ICT-05-2014;H2020;architectuRe for an Internet For Everybody;1/02/2015;31/01/2018;;RIFE addresses the major societal challenge of providing affordable Internet access to those who cannot afford it by solving the technological challenge to increase the efficiency of the underlying transport networks and the involved architectures and protocols. The RIFE solution will harness unused transmission capacity, combined with placing content caches and service functionality closer to the user and will use heterogeneous transmission opportunities that range from localized mesh and home networks over well-connected ISP backhauls to scarce satellite resources. RIFE will build upon recent advances on information-centric and delay-tolerant networking by developing optimized dissemination strategies for the involved transport networks, unified within a novel communication architecture that will provide clear abstractions to application developers. We will develop, deploy and showcase our solution in a real-life setting within a large-scale community network in Spain, demonstrating the technology and economic opportunities that the RIFE platform provides. We will complement our real-life testbeds with emulation scenarios to enable the evaluation of our novel resource management schemes at scale, while integrating with our prototype platform. On the economic side, we will develop business opportunities for local authorities as well as backhaul network providers to create a sustainable value chain by introducing virtual network operators that utilize the under-used capacity in a new business relationship with local customers, enabling novel and often socially-driven business models. The involvement of a technology, equipment, as well as satellite and community network provider will allow for maximizing the commercial exploitation of RIFE within real deployments and towards standard communities within the IETF/IRTF and beyond, placing RIFE in the centre of a growing community of practitioners that all share the same goal: making the Internet affordable to everybody!;3185001,25;2930626,25;H2020-ICT-2014-1;RIA;MARTEL GMBH;CH;"THALES ALENIA SPACE FRANCE;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;INTERDIGITAL EUROPE LTD;TECHNISCHE UNIVERSITAET MUENCHEN;FUNDACIO PRIVADA PER A LA XARXA OBERTA, LLIURE I NEUTRAL, GUIFI.NET;AALTO-KORKEAKOULUSAATIO;AVANTI HYLAS 2 CYPRUS LIMITED";"FR;UK;DE;ES;FI;CY"; 194388;645767;VirCoin2SME;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Social, complementary or community virtual currencies transfer of knowledge to SME: a new era for competitiveness and entrepreneurship;1/12/2014;30/11/2016;;"With the advent of social networks and Mobile networks, new online communities are being created around sustainable topics (environmental, social, community development). The phenomena, known as digital social innovation, generates a positive ecosystem where business and social development enabled with new behaviours boosted by social, complementary or community currencies deployed as virtual currencies have a great potential for competitiveness, and entrepreneurship, but also for fostering social responsibility in Europe.
VirCoin2SME projects aims at studying how the business development could be fully deployed around the ecosystem of social networks and virtual currencies, which facilities new exchanges for wealthier communities.
Research objectives to be developed in VirCoin2SME project are:
1.To compare different models of social networks influence on business processes
2.To analyze the mechanisms behind the adoption of social, complementary or community virtual currencies.
3.To research on the potential impact of digital innovation and alternative currencies development in social, environmental and economic sustainability.
4.To develop two sector-oriented proposals/guidelines (healthcare and tourism) for developing sustainable business models based on the use of complementary and/or virtual currencies
The previous research objectives will be achieved by implementing a collaborative working scheme where research entities will design the methodology and elaborate final guidelines to develop, according to the actual business scenarios defined and analyzed by the private companies involved in VirCoin2SME, in the two respective sectors that will act as use cases for study and proposals development: healthcare and tourism.
Dissemination and communication activities will be designed and developed in parallel to ensure the wider impact of the knowledge generated and to foster new business generation around sustainable models not only in Europe,but internationally.";378000;378000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITAT DE GIRONA;ES;"EASY INNOVA S.L.;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;ADMIN LEUVEN bvba";"ES;DE;BE"; 194089;643666;I-SUPPORT;SIGNED;H2020-EU.3.1.;PHC-19-2014;H2020;ICT-Supported Bath Robots;1/03/2015;28/02/2018;;The I-SUPPORT project envisions the development and integration of an innovative, modular, ICT-supported service robotics system that supports and enhances older adults motion and force abilities and assists them in successfully, safely and independently completing the entire sequence of bathing tasks, such as properly washing their back, their upper parts, their lower limbs, their buttocks and groin, and to effectively use the towel for drying purposes. Advanced modules of cognition, sensing, context awareness and actuation will be developed and seamlessly integrated into the service robotics system to enable the robotic bathing system to adapt to the frail elderly population capabilities and the frail elderly to interact in a master-slave mode, thus, performing bathing activities in an intuitive and safe way. Adaptation and integration of state-of-the-art, cost-effective, soft-robotic manipulators will provide the hardware constituents, which, together with advanced human-robot force/compliance control that will be developed within the proposed project, will form the basis for a safe physical human-robot interaction that complies with the most up-to-date safety standards. Human behavioural, sociological, safety, ethical and acceptability aspects, as well as financial factors related to the proposed service robotic infrastructure will be thoroughly investigated and evaluated so that the I-SUPPORT end result is a close-to-market prototype, applicable to realistic living settings.;3563198,75;3563198;H2020-PHC-2014-single-stage;RIA;ROBOTNIK AUTOMATION SLL;ES;"BETHANIEN KRANKENHAUS - GERIATRISCHES ZENTRUM - GEMEINNUTZIGE GMBH;SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;THEOFANIS ALEXANDRIDIS KAI SIA EE;FRANKFURT UNIVERSITY OF APPLIED SCIENCES;KARLSRUHER INSTITUT FUER TECHNOLOGIE;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;FONDAZIONE SANTA LUCIA;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS";"DE;IT;EL;FR"; 194116;643937;EDSA;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;European Data Science Academy;1/02/2015;31/01/2018;;"Data explosion on the web, fuelled by social networking, micro-blogging, as well as crowdsourcing, has led to the Big Data phenomenon. This is characterized by increasing volumes of structured, semi-structured and unstructured data, originating from sources that generate them at an increasing rate. This wealth of data provides numerous new analytic and business intelligence opportunities to various industry sectors. Therefore, more and more industry sectors are in need of innovative data management services, creating a demand for Data Scientists possessing skills and detailed knowledge in this area. Ensuring the availability of such expertise will prove crucial if businesses are to reap the full benefits of these advanced data management technologies, and the know-how accumulated over the past years by researchers, technology enthusiasts and early adopters.

The European Data Science Academy (EDSA) will establish a virtuous learning production cycle whereby we: a) analyse the required sector specific skillsets for data analysts across the main industrial sectors in Europe; b) develop modular and adaptable data science curricula to meet these needs; and c) deliver training supported by multiplatform and multilingual learning resources based on our curricula. The curricula and learning resources will be continuously evaluated by pedagogical and data science experts during both development and deployment.";2976189,75;2976189,75;H2020-ICT-2014-1;CSA;THE OPEN UNIVERSITY;UK;"KUNGLIGA TEKNISKA HOEGSKOLAN;INSTITUT JOZEF STEFAN;OPEN DATA INSTITUTE LBG;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;PERSONTYLE LIMITED;UNIVERSITY OF SOUTHAMPTON;IDEXLAB SAS;TECHNISCHE UNIVERSITEIT EINDHOVEN";"SE;SI;UK;DE;FR;NL"; 194127;643998;ENACT;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Enhancing sustainable chemical technologies through the synergy of computer simulation and experiment;1/01/2015;31/12/2018;;"The main aim of the ENACT project is to combine computer simulation with materials synthesis and experimental characterization to optimize the design of liquid-phase systems for chemical technologies. By optimization, we understand an improvement in efficiency, sustainability and environmental impact. The quest for such processes is rapidly becoming a necessity in a global scale. Air pollution, energy shortages, and global warming are very serious matters, whose remediation we embrace here as an integral part of the research agenda.

This goal will be achieved by first gaining an understanding of the structural, dynamical, and thermodynamic properties of a variety of systems by means of computer simulation. This will allow us to tune their properties by modifying at will, in silico, the choice of materials and external conditions. This knowledge will be then transferred to the experimental partners who will synthesize and characterize the selected systems. If they do not perform as expected, or prove difficult or expensive to produce, a new computational cycle will be required. If they do work, simulation will be used again to fine-tune them. A particularly innovative aspect is that six independent themes will be tackled in parallel under a single umbrella, thus enabling the exchange of ideas and methods between them and paving the way to unexpected technologies arising from cross-fertilization between the various themes.

This programme will be accomplished with the participation of four institutions: QUB (UK), UCD (Ireland), ISIS (UK) and UNCUYO (Argentina) with complementary expertise in various aspects of materials modelling, synthesis and characterization. To exploit in an optimal way this distributed expertise, a generous scheme of training (School and Workshops) and secondments has been put in place for ESRs, with shorter visits of ERs. Outreach activities have been included to target the general public and businesses, for exploitation of results.";670500;670500;H2020-MSCA-RISE-2014;MSCA-RISE;THE QUEEN'S UNIVERSITY OF BELFAST;UK;"SCIENCE AND TECHNOLOGY FACILITIES COUNCIL;UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN";"UK;IE"; 194095;643712;GreenBubbles;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Green Bubbles RISE for sustainable diving;1/01/2015;31/12/2018;;"Recreational SCUBA divinga has become a mass leisure activity engaging millions of divers worldwide. The diving industry generates large direct and indirect revenues for coastal communities and Marine Protected Areas (MPAs). Other benefits linked to diving include the promotion of ocean stewardship, contribution to scientific research, fostering social inclusion and personal development. Yet, diving has also negative impacts, due to damage or disturbance of marine habitats and organisms and to conflicts with local communities for the access to/use of the same resources, equity issues, or cultural clashes. These aspects clearly relate to the three pillars of sustainability, covering environmental, economic and social dimensions and can only be addressed by a systemic approach.
The central objective of GREEN BUBBLES is to maximise the benefits associated with diving while minimising its negative impacts, thus achieving the environmental, economic and social sustainability of the system. This will be done by: 1) Carefully assessing and modelling the system itself; 2) Developing innovative products based on the issues and needs highlighted by assessment and modelling; 3) Promoting the uptake of such products by the system designing tailored business models and marketing plans. Direct engagement with selected stakeholders (divers, professionalsb, diving operators, certification agencies - CAs, MPAs, NGOs) will ensure relevant feedback throughout the projects lifetime, as well as effective uptake of results at the end of the project. Cutting across sectors and disciplines, and engaging participants from 3 continents, GREEN BUBBLES will put the European diving system in focus thanks to dedicated R&I with, about and for the European diving industry and will take advantage of parallel comparative work on the much more studied coral reef diving system.";1620000;1611000;H2020-MSCA-RISE-2014;MSCA-RISE;UNIVERSITA POLITECNICA DELLE MARCHE;IT;"DIVERS ALERT NETWORK EUROPE FOUNDATION;STUDIO ASSOCIATO GAIA SNC DEI DOTTORI ANTONIO SARA E MARTINA MILANESE;UBICA SRL;STICHTING NHTV INTERNATIONALE HOGESCHOOL BREDA;BOGAZICI ULUSLARARASI EGITIM DANISMANLIK MERKEZI VE TICARET LIMITED SIRKETI";"MT;IT;NL;TR"; 194189;644329;SAEPP;SIGNED;H2020-EU.2.1.1.;ICT-35-2014;H2020;Smart Ambulance: European Procurers Platform (SAEPP);1/01/2015;31/08/2015;;The objective of this project is to create and collate a consensus of agreement from Ambulance Users and Procurers on the core technology-centric features which, if correctly integrated into a suitably re-designed ambulance, would allow them to demonstrate, evaluate and deliver new models of in-community healthcare delivery, with the primary objective of avoiding unnecessary hospital attendances (& thus admissions) and the associated patient distress and hospital costs. Such a consensus would form the basis of a future PCP for the envisaged vehicle, and such a PCP Specification is in fact an output of this proposed work.;443600;443600;H2020-ICT-2014-1;CSA;SURREY AND BORDERS PARTNERSHIP NHS FOUNDATION TRUST;UK;"INEM;SOUTH EAST COAST AMBULANCE SERVICE NHS FOUNDATION TRUST;FUNDACION TECNALIA RESEARCH & INNOVATION;Falck Danmark A/S;LAPPEENRANNAN TEKNILLINEN YLIOPISTO;YORKSHIRE AMBULANCE SERVICE NHS TRUST;THE ROYAL COLLEGE OF ART;BITECIC LIMITED;UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL;ETELA-KARJALAN SOSIAALI- JA TERVEYDENHUOLLON KUNTAYHTYMA;Saimaan ammattikorkeakoulu Oy;ACADEMISCH ZIEKENHUIS GRONINGEN;THE UNIVERSITY OF SHEFFIELD;REGION SJAELLAND;FUNDACION PARA LA INVESTIGACION BIOMEDICA DE CORDOBA;AMBULANCE TODAY LTD";"PT;UK;ES;DK;FI;NL"; 194295;645216;Idealist2018;SIGNED;H2020-EU.2.1.1.;ICT-33-2014;H2020;Transnational Cooperation among ICT NCPs;1/01/2015;31/12/2018;;"The main objective of Idealist2018 is reinforcing the network of National Contact Points (NCP) for LEIT ICT under Horizon2020, by promoting further trans-national cooperation within this network. This cooperation will also include collaboration and networking with similar networks in parallel themes (Security, ENV, Transport, Energy, Health,etc) especially in the context of joint/coordinated or PPP calls.

Special focus is put on helping less experienced NCPs from Member States (MS) and Associated Countries (AC) to access the know-how accumulated in other countries and to apply it in a locally relevant and efficient manner.

Furthermore Idealist2018 aims to address national and cross-border audiences, relying on the NCP network mainly established in the MS and AC at national and regional level, to stimulate, encourage and facilitate the participation of current and future ICT research stakeholders in ERA. Special focus is put on newcomers and SMEs, including organisations from MS, AC and third Countries.

The activities of Idealist2014 are incremental to the formal NCP responsibilities as they address the international aspects not covered by the nationally funded NCP role. It is built upon:
-Experience gained over more than 15 years from the 8 preceding projects covering FP4 to FP7 and now the transition to H2020
-Strengthening NCP cooperation with support for MS, AC and third Countries
-Provision of Training and Twinning for less experienced NCPs
-Provision of partner search, pre- and full proposal quality support
-Focused support for SMEs in the ICT sector and for organisations new to H2020
-Provision of NCP support for countries with S&T international agreements
-Promotion of opportunities and Idealist services ensuring a higher NCP visibility";4271525,31;3999995,31;H2020-ICT-2014-1;CSA;MATIMOP - THE ISRAELI CENTER FOR R&D;IL;"EFPC ( UK ) LTD;UNION WALLONNE DES ENTREPRISES ASBL;INSTITUTO TECNOLOGICO Y DE ESTUDIOS SUPERIORES DE MONTERREY;STARPTAUTISKA LIETISKAS OPTIKAS BIEDRIBA;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;CENTRUL PENTRU FINANTAREA CERCETARII FUNDAMENTALE SI APLICATIVE;SIHTASUTUS EESTI TEADUSAGENTUUR;THE ICELANDIC CENTRE FOR RESEARCH;INFORMATION SOCIETY TECHNOLOGIES CENTER;INNOREG KOZEP-MAGYARORSZAGI REGIONALIS INNOVACIOS UGYNOKSEG KOZHASZNU EGYESULET;IDRYMA PROOTHISIS EREVNAS;SINGLEIMAGE LIMITED;TECHNOLOGICKE CENTRUM AKADEMIE VED CESKE REPUBLIKY;AGENCE BRUXELLOISE POUR L'ENTREPRISE;International Center for Advancement of Research, Technology and Innovation;UNIVERSIDAD GALILEO;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;NORGES FORSKNINGSRAD;BELARUSIAN INSTITUTE OF SYSTEM ANALYSIS AND INFORMATION SUPPORT OF SCIENTIFIC AND TECHNICAL SPHERE;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;INSTITUTE OF INFORMATION AND COMMUNICATION TECHNOLOGIES;VEREIN EURESEARCH;CENTRUM VEDECKO TECHNICKYCH INFORMACII SLOVENSKEJ REPUBLIKY;CENTRO PARA EL DESARROLLO TECNOLOGICO INDUSTRIAL.;ETHNIKO IDRYMA EREVNON;INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN INFORMATICA ICI BUCURESTI RA;LUXINNOVATION GIE;UBIFRANCE*AGENCE FRANCAISE POUR LE DEVELOPPEMENT INTERNATIONAL DES ENTREPRISES;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;Ministerio de Ciencia, Tecnologa e Innovacin Productiva;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"UK;BE;MX;LV;AT;MD;EE;IS;AM;HU;CY;CZ;GE;GT;PL;NO;BY;HR;BG;CH;SK;ES;EL;RO;LU;FR;IT;AR;PT"; 194171;644209;HEAT;SIGNED;H2020-EU.2.1.1.;ICT-32-2014;H2020;Homomorphic Encryption Applications and Technology;1/01/2015;31/12/2017;;"Homomorphic cryptography offers the tantalizing goal of being able to process sensitive information in encrypted form, without needing to compromise on the privacy and security of the citizens and organizations that provide the input data.

The HEAT proposal brings together Europe's leading researchers on homomorphic cryptography (KU LEUVEN, UNIVBRIS and UL), with the leading expertise on lattice based cryptanalysis (UPMC), and three industrial partners with existing interests in the field (CRX, NXP and Thales UK). The goal of HEAT is to produce a step change in the efficiency and applicability of this technology. The proposal leverages existing ground breaking research in Europe, and links this with three industrially contributed case studies as a way of grounding the research in practical issues.

The case studies proposed by the industrial partners consist of smart grid, statistical analysis to automate the detection of organized crime and shared satellite infrastructure applications.

The project will focus on Somewhat Homomorphic Encryption (SHE). Not only is this a stepping stone on the way to Fully Homomorphic Encryption, the partners also believe that SHE is a useful cryptographic tool in its own right. We aim to demonstrate this applicability via our three case studies.

Motivated by the three case studies the project will examine new design and implementation techniques for homomorphic cryptography, as well as a thorough security analysis. The security analysis is likely to have wider applicability due to the linkage with post-quantum cryptographic systems based on lattices. The proposed outputs of HEAT are an open source software library to support applications that wish to use homomorphic cryptography. The results of the HEAT project will be highly beneficial to European industry and academic research since they allow for using homomorphic cryptography to be used by a much wider variety of end developers.";4165726,25;4165726,25;H2020-ICT-2014-1;RIA;KATHOLIEKE UNIVERSITEIT LEUVEN;BE;"THALES UK LIMITED;UNIVERSITE DU LUXEMBOURG;UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6;NXP SEMICONDUCTORS BELGIUM NV;CRYPTOEXPERTS SAS;UNIVERSITY OF BRISTOL";"UK;LU;FR;BE"; 194373;645725;FRIENDS2;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Framework of Innovation for Engineering of New Durable Solar Surfaces;1/01/2015;31/12/2018;;Increasing the share of renewables in the European energy mix has a key function for the security of energy supply and the reduction of greenhouse gas emissions from fossil fuels. This proposal is entitled Framework of Innovation for Engineering of New Durable Solar Surfaces, (acronym FRIENDS2) and aims at achieving a European network for the transfer of knowledge to establish a shared culture of research and innovation which allows turning creative ideas in the field of surface engineering into innovative solutions for concentrating solar power (CSP) applications. FRIENDS2 will be led by one large European industry (Abengoa) who is a world leader in the development of CSP plants. The other FRIENDS2 participants are two well-recognized academic organizations (the University of Cranfield and the Helmholtz-Zentrum Dresden - Rossendorf e.V.), and one SME (Metal Estalki). The purpose of FRIENDS2 is to strengthen the inter-sectoral capabilities in research and development of coating designs in order to improve the performance of CSP key components (reflectors, receivers and containers for heat storage) for high temperature applications. The methodology of this joint research proposal contains aspects of very high novelty. It includes computer modelling, multi-technique coating deposition, use of advanced characterization techniques, and the possibility of scaling-up new coating developments. Special attention is paid to the intersectoral transfer of knowledge and to the establishment of a long-lasting international network with global impact. It is worth noting that a substantial fraction of secondments (51%) will be carried out from the industrial to the academic sector. With the proposed approach, there will be an effective transfer of knowledge among the partners which will pave the road from fundamental research to applied innovation of surface engineering solutions for further CSP development.;454500;454500;H2020-MSCA-RISE-2014;MSCA-RISE;ABENGOA RESEARCH SL;ES;"METAL ESTALKI SL;CRANFIELD UNIVERSITY;HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV";"ES;UK;DE"; 194214;644497;proDataMarket;SIGNED;H2020-EU.2.1.1.4.;ICT-15-2014;H2020;Enabling the property Data Marketplace for Novel Data-driven Business Models;1/03/2015;31/08/2017;;"Property data are one of the most valuable datasets managed by governments worldwide and extensively used in various domains by private and public organizations. Unfortunately these data are not always easy to access. House and property data is used in a variety of ways to produce value added information within and across several business sectors, including real estate and debt collection. Such sectors suffer from a lack of innovation due to a fragmented data ecosystem which makes it difficult to access relevant datasets. This hampers innovation, protects incumbents and promotes rent-seeking business models. The difficulty in creating a single, open data market partly depends on the fact that some governmental agencies are currently making significant revenues on selling data to a restricted number of business players in the private sector. However, several studies, demonstrated that the transaction costs for government agencies tend to be very high, and often make selling the data non-profitable.
proDataMarket aims to disrupt the property data market and demonstrate innovation across sectors where property data is relevant, by integrating a technical framework for effective publishing and consumption of property-related data, showcasing novel data-driven business products and services based on property data. proDataMarket will provide a digital data marketplace for open and non-open property and related contextual data, making it easier for data providers to publish and distribute their data (for free or for a fee) and for data consumers to easily access the data they need for their businesses.
The consortium is formed by large companies ensuring high-impact business cases, technology transfer providers ensuring technologies for the creation and maintenance of the data market platform, and large data providers providing data for the business cases. With strong industry involvement proDataMarket will cover a wide range of data value chains related to property data.";4482957;3499144,5;H2020-ICT-2014-1;IA;STIFTELSEN SINTEF;NO;"EMPRESA DE TRANSFORMACION AGRARIA SA;SPAZIODATI SRL;ONTOTEXT AD;CERVED GROUP SPA;EVRY NORGE AS;ISTITUTO NAZIONALE DI STATISTICA;KOMMUNAL- OG MODERNISERINGSDEPARTEMENTET";"ES;IT;BG;NO"; 194074;643535;WOMEN-UP;SIGNED;H2020-EU.3.1.;PHC-26-2014;H2020;Cost effective self-management of urinary incontinence addressed to women across Europe;1/02/2015;31/07/2018;;"Urinary incontinence (UI), considered as a disease according to the World Health Organization (WHO), is not a life-threatening condition, but causes a very negative impact on daily living and quality of life. 56 million European citizens are affected by UI, which represents a serious impairment to the quality of their professional and personal life. Recent statistics show that 346 million people worldwide experienced any type of UI in 2008, which will increase to 420 million by 2018. In addition, when UI appears it is maintained throughout a lifetime if no solution is provided, causing huge social and economic costs (nearly $10 billion is lost every year in direct treatment cost and lost productivity due to UI).

The main objective of WOMEN-UP project is to improve the quality of life of urinary incontinence patients through a holistic and cost-effective ICT-solution, allowing for the self management of the chronic UI disease via a decision support system and a secure remote medical supervision.

This general objective is divided into the following specific objectives:

-To improve womens health by providing lifestyle changes through an integral and multifactorial treatment.
-To develop an ICT-based system to facilitate a holistic solution for a conservative home treatment: Lifestyle interventions and pelvic floor muscle training with remote clinical assessment and supervision.
-To make eHealth tools for UI more effective, user-friendly and widely accepted by involving professionals and patients in strategy, design and implementation.
-To assess the cost-efficiency of the proposed ICT-based solution for significantly reducing health system costs by up to 72%
-To develop an innovative approach for the supervision of Pelvic Floor Muscles Training
-To increase patient

The project WOMEN-UP will be developed by a consortium that brings together 9 partners from 6 different EU member states (Spain, Finland, Netherlands, Czech Republic, Romania, and Switzerland).";3470257,59;3245256,84;H2020-PHC-2014-single-stage;RIA;UNIVERSITAT POLITECNICA DE CATALUNYA;ES;"MEGA ELEKTRONIIKKA OY;EVROPSKA UROGYNEKOLOGICKA SPOLECNOST;FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA;POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA;UNIVERSITATEA BABES BOLYAI;BAP HEALTH OUTCOMES RESEARCH SL;YOUREHAB AG;Academisch Medisch Centrum bij de Universiteit van Amsterdam";"FI;CZ;ES;RO;CH;NL"; 194076;643558;EMI-TB;SIGNED;H2020-EU.3.1.;PHC-08-2014;H2020;Eliciting Mucosal Immunity to Tuberculosis;1/01/2015;31/12/2018;;Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8\ T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.;7999920,11;7993660;H2020-PHC-2014-single-stage;RIA;ST GEORGE'S HOSPITAL MEDICAL SCHOOL;UK;"LIONEX GMBH;Instituto Nacional de Sade;AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS;Department of Health;KAROLINSKA INSTITUTET;SPOREGEN LIMITED;INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL;MIKROBIOLOGICKY USTAV - AVCR, V.V.I.;AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO;UNIVERSIDAD DE VIGO;KING'S COLLEGE LONDON;STOCKHOLMS UNIVERSITET;UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA";"DE;MZ;ES;UK;SE;CZ;IT"; 194195;644348;MagIC;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;MagIC Magnonics, Interactions and Complexity: a multifunctional aspects of spin wave dynamics;1/02/2015;31/01/2019;;The artificial patterning of nanoscale structures provides an excellent opportunity for modifying spectra of their excitations, and therefore for designing materials with unforeseen properties. Newly created materials (photonic, magnonic or plasmonic) serve as promising candidates for technological applications in integrated devices with smart functionalities for optoelectronic applications, nanoscale thermal transport control, charge free storage and manipulation of information. Magnetic materials with periodically modulated properties, magnonic crystals (MCs) offer two main distinctive features from which the technology can benefit. Firstly, MCs facilitate tunable excitation spectra controlled via magnetic field. Secondly, being non-volatile materials they facilitate exploitation of the re-programmable properties. Hence, significant international research effort in MagIC is now devoted to the area of magnonics and its cross disciplinary opportunities with photonics, phononics and electronics. The frontiers of new ideas, pushing the limits of knowledge, will be developed. The most prominent directions of research are the exploration of nonlinear effects in MCs, tailoring effective damping, developing theoretical models of the spin wave scattering in nanoscale, investigating effects of the broken periodicity and fractal structures on magnonic spectra. Moreover, MagIC will exploit still unexplored directions of mutual coexistence of magnonic functionalities with these of photonic, plasmonic or phononic in a single nanostructure. The academic exchange (168 months of visits in 4 years) supplemented with abundant network and outreach activities will aim to continue existing collaboration, establishing new links, supporting multilateral transfer of knowledge and expertise among seven European and Ukraine research teams, striving to advance the aforementioned research fields, development of innovation and career for research and innovation staff members.;756000;697500;H2020-MSCA-RISE-2014;MSCA-RISE;UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU;PL;"THE UNIVERSITY OF EXETER;INSTYTUT FIZYKI MOLEKULARNEJ, POLSKIEJ AKADEMII NAUK;UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA";"UK;PL;ES"; 194280;645097;COMANOID;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Multi-contact Collaborative Humanoids in Aircraft Manufacturing;1/01/2015;31/12/2018;;"COMANOID investigates the deployment of robotic solutions in well-identified Airbus airliner assembly operations that are laborious or tedious for human workers and for which access is impossible for wheeled or rail-ported robotic platforms. As a solution to these constraints a humanoid robot is proposed to achieve the described tasks in real-use cases provided by Airbus Group. At a first glance, a humanoid robotic solution appears extremely risky, since the operations to be conducted are in highly constrained aircraft cavities with non-uniform (cargo) structures. Furthermore, these tight spaces are to be shared with human workers. Recent developments, however, in multi-contact planning and control suggest that this is a much more plausible solution than current alternatives such as a manipulator mounted on multi-legged base. Indeed, if humanoid robots can efficiently exploit their surroundings in order to support themselves during motion and manipulation, they can ensure balance and stability, move in non-gaited (acyclic) ways through narrow passages, and also increase operational forces by creating closed-kinematic chains. Bipedal robots are well suited to narrow environments specifically because they are able to perform manipulation using only small support areas. Moreover, the stability benefits of multi-legged robots that have larger support areas are largely lost when the manipulator must be brought close, or even beyond, the support borders. COMANOID aims at assessing clearly how far the state-of-the-art stands from such novel technologies. In particular the project focuses on implementing a real-world humanoid robotics solution using the best of research and innovation. The main challenge will be to integrate current scientific and technological advances including multi-contact planning and control; advanced visual-haptic servoing; perception and localization; human-robot safety and the operational efficiency of cobotics solutions in airliner manufacturing.";4244481,25;4244481,25;H2020-ICT-2014-1;RIA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS;FR;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE;UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA;AIRBUS GROUP SAS";"DE;FR;IT"; 194101;643776;TREGeneration;SIGNED;H2020-EU.3.1.;PHC-15-2014;H2020;Repair of tissue and organ damage in refractory chronic graft versus host disease after hematopoietic stem cell transplantation by the infusion of purified allogeneic donor regulatory T lymphocytes;1/01/2015;31/12/2019;;"Our proposal encompasses parallel clinical trials addressing the feasibility and the effectiveness of donor-derived regulatory T cells (Treg) as a therapeutic agent in the treatment and prevention of tissue and organ damage resulting from graft versus host disease (GVHD) after hematopoietic stem cell transplantation (HSCT).
We propose a collaborative clinical study in which Treg therapy for GHVD is the common dominator. However, by bringing together several clinical centers with expertise in this area, we are also having the opportunity to simultaneously address other issues that would not otherwise be addressable by each clinical center on its own. Firstly, by using different Treg preparation strategies, we will be able to determine whether ex vivo isolated Treg are sufficient or whether in vitro expansion and subsequently higher dosages are required. Secondly, we will investigate if sole Treg infusion is effective or if rather co-administration of therapeutic agents that are likely to induce Treg survival and expansion in vivo (rapamycin; IL-2) is required for a successful response to Treg therapy.
The studies on GVHD treatment outcome will be pursued together with a detailed analysis of immune monitoring, comprising T cell receptor clonotype tracking and tissue regeneration markers, in order to further understand the mechanisms underlying the therapeutic and regenerative potential of Treg cells.
Our consortium has developed a concerted approach to the topic of Treg therapy in GVHD. This is a unique opportunity to determine the validity of this cellular immunotherapy approach in GVHD prevention and treatment, with potential for a significant impact on patient quality of life, survival rate and ultimately on the quality of health care provided.";5899250;5899250;H2020-PHC-2014-single-stage;RIA;INSTITUTO DE MEDICINA MOLECULAR;PT;"UNIVERSITE DE LIEGE;MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV;KLINIKUM DER UNIVERSITAET REGENSBURG;THE UNIVERSITY OF LIVERPOOL;AZIENDA OSPEDALIERO UNIVERSITARIA POLICLINICO S. ORSOLA MALPIGHI;GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG;Alacris Theranostics GmbH";"BE;DE;UK;IT"; 194112;643892;RADIO;SIGNED;H2020-EU.3.1.;PHC-19-2014;H2020;Robots in assisted living environments: Unobtrusive, efficient, reliable and modular solutions for independent ageing;1/04/2015;31/03/2018;;"Demographic and epidemiologic transitions have brought a new health care paradigm with the presence of both, growing elderly population and chronic diseases. Life expectancy is increasing as well as the need for long-term care. Institutional care for the aged population faces economical struggles with low staffing ratios and consequent quality problems.
Although the aforementioned implications of ageing impose societal challenges, at the same time new opportunities arise for the European citizens, the healthcare systems as well as the industry and the European market.
Two of the most important aspects of assistive environments and independent living are user acceptance and unobtrusiveness. Mostly explored in a smart home setup and the unobtrusive installation of audio-visual monitoring equipment, the consensus is that users accept monitoring if they are not constantly aware of its presence. A more recent trend is home assistant robots. These two lines of development have for the most part ran without heavily interacting with each other and, even more so, without developing integrated solutions that combine smart home automation with robotics. In RADIO, we will develop an integrated smart home/assistant robot system, with the objective of pursuing a novel approach to acceptance and unobtrusiveness: a system where sensing equipment is not discrete but an obvious and accepted part of the users daily life.
By using the integrated smart home/assistant robot system as the sensing equipment for health monitoring, we mask the functionality of the sensors rather than the sensors themselves. In this manner, sensors do not need to be discrete and distant or masked and cumbersome to install; they do however need to be perceived as a natural component of the smart home/assistant robot functionalities.";3805625;3805625;H2020-PHC-2014-single-stage;RIA;"""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS""""""";EL;"APHOI KOUMANAKOU & SIA EE;SENSING & CONTROL SYSTEMS SL;AVN INNOVATIVE TECHNOLOGY SOLUTIONS LIMITED;FONDAZIONE SANTA LUCIA;RUHR-UNIVERSITAET BOCHUM;ROBOTNIK AUTOMATION SLL;FUNDACION PRIVADA HOSPITAL ASIL DEGRANOLLERS;TECHNOLOGIKO EKPAIDEFTIKO IDRYMA (TEI) DYTIKIS ELLADAS";"EL;ES;CY;IT;DE"; 194358;645676;MULTISURF;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;MULTI-functional metallic SURFaces via active Layered Double Hydroxide treatments;1/01/2015;31/12/2018;;"The main objective of the proposal is development of active multi-functional surfaces with high level of self-healing ability on the basis of Layered Double Hydroxide (LDH) structures formed on different industrially relevant metallic substrates. The main idea of the project is based on smart triggered release on demand for functional organic or inorganic anionic compounds intercalated into intergallery spaces of LDHs. The active functionality is achieved via controllable substrate-governed growth of LDH architectures on Al, Mg and Zn based alloys. The functional anions such as corrosion inhibitors, biocides, drugs, or hydrophobic agents are introduced into the intergallery spaces during the growth of LDH or upon a post-treatment stage. The release of the functional agents occurs only on demand when the respective functionality is triggered by the relevant external stimuli such as presence of anions or local pH change.
The proposal focuses on two main applications, namely aeronautical and automotive. The active LDH treatments can bring significant benefits when applied in these situations. The respective relevant substrates are chosen as the main objects of interest: Mg alloys for both applications; Al alloys for both transportation industries as well; galvanized steel as a main material for automobiles. Moreover the suggested surface treatments, especially the one with active self-healing ability, are also considered for light-weight multi-material structures which are prone to fast galvanically-induced corrosion. The increase of the fault tolerance and reliability of hybrid designs is aimed in this case. The suggested surface treatments can offer possibility for fast implementation of the process at industrial level.
The main expected impacts are related to the improvement of the life cycle of the light-weight structures utilized in transport industries via optimization of the maintenance schedules and increasing the fault tolerance.";648000;648000;H2020-MSCA-RISE-2014;MSCA-RISE;HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH;DE;"AIRBUS DEFENCE AND SPACE GMBH;UNIVERSIDADE DE AVEIRO;SMALLMATEK - SMALL MATERIALS AND TECHNOLOGIES LDA";"DE;PT"; 194174;644235;RePhrase;SIGNED;H2020-EU.2.1.1.3.;ICT-09-2014;H2020;REfactoring Parallel Heterogeneous Resource-Aware Applications - a Software Engineering Approach;1/04/2015;31/03/2018;;"'The RePhrase project directly meets the challenge of ICT-09-2014, by studying the critically important issue of improving software development practice for parallel data-intensive applications. Data-intensive applications are among the most important and commonly encountered kinds of industrial application, and are increasingly important with the emergence of 'big data' problems. Emerging heterogeneous parallel architectures form ideal platforms to exploit the massive-scale inherent parallelism that is usually implicit in such applications, but which is often difficult to extract in practice.
Solving this problem will bring major economic benefits to the software industry.
To address this challenge, RePhrase brings together a team of leading industrial and academic researchers, software engineers, systems developers, parallelism experts and domain experts from large companies, SMEs and leading universities. It aims to develop a novel software engineering methodology for developing complex, large-scale parallel data-intensive applications, supported by a very high-level programming model. We will exploit advanced pattern-based programming, refactoring, testing, debugging, verification and adaptive-scheduling technologies to build an interoperable tool-chain supporting our methodology, based on but significantly extending existing industrial and research tools. These tools will significantly ease, and even automate, all phases of typical software development, from design and implementation to long-term maintenance and software evolution. The generality of our approach will be ensured by targeting C\\ and the most popular low-level parallel programming models, such as the C\\11/14/17 standards, pthreads, OpenMP, Intel TBB, OpenCL and CUDA. We will demonstrate our approach on a range of large-scale data-intensive applications, taken from different domains, including bio-medical image processing, data analysis, machine learning, computer vision and railway diagnosis.'";3574027;3574027;H2020-ICT-2014-1;RIA;THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS;UK;"EVOPRO INNOVATION KFT;UNIVERSITA DI PISA;UNIVERSITA DEGLI STUDI DI TORINO;PROGRAMMING RESEARCH LTD;CENTRO DE INVESTIGACION BIOMEDICA EN RED;IBM ISRAEL - SCIENCE AND TECHNOLOGY LTD;UNIVERSIDAD CARLOS III DE MADRID;SOFTWARE COMPETENCE CENTER HAGENBERG GMBH";"HU;IT;UK;ES;IL;AT"; 194312;645360;ORCHESTRA;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;Optical peRformanCe monitoring enabling dynamic networks using a Holistic cross-layEr, Self-configurable Truly flexible appRoAch;1/02/2015;31/01/2018;;"An optical network, like any system, has to be observable before it can become controllable and be subject to optimization, and this is the first capability ORCHESTRA introduces. ORCHESTRAs high observability relies on information provided by the coherent transceivers that are extended, almost for free, to operate as software defined multi-impairment optical performance monitors (soft-OPM). Information from multiple soft-OPMs are correlated using network kriging and statistical estimation methods to infer information for unmonitored or un-established paths, effectively support alien wavelength, and localize QoT problems and failures.
High rate optical transmission with coherent detection promises to address the continuous growth of Internet traffic. However, the current control and monitoring (C&M) infrastructure is absolutely not adequate to support this growth. In ORCHESTRA, a new C&M architecture that exploits the monitoring and reconfigurability capabilities of enhanced tubable transceivers will be designed, implemented and validated. The network is viewed as a continuously running process that perceives current conditions, decides, and acts on those conditions. ORCHESTRAs advanced cross-layer optimization procedures will be implemented within a new specifically designed library module, called DEPLOY. A new dynamic and hierarchical C&M infrastructure will be then created to interconnect the multiple soft-OPMs and the proposed virtual and real C&M entities running the DEPLOY algorithms. At the top of the hierarchical infrastructure, a novel OAM Handler prototype will be implemented, as part of the SDN-based ABNO architecture. The proposed C&M infrastructure will be enriched with active-control functionalities, closing the control loop, and enabling the network to be truly dynamic and self-optimized.
The ORCHESTRA solutions are planned to be industrialized, given the expected improvements in service level validations, CAPEX, energy consumption and OPEX.";2620831,25;2620331;H2020-ICT-2014-1;RIA;INSTITOUTO TECHNOLOGIAS YPOLOGISTONKAI EKDOSEON DIOFANTOS;EL;"SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA;TELECOM ITALIA SPA;ALCATEL - LUCENT BELL LABS FRANCE;NEXTWORKS;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS";"IT;FR;EL"; 194080;643578;E-Rare-3;SIGNED;H2020-EU.3.1.;HCO-10-2014;H2020;ERA-NET rare disease research implementing IRDiRC objectives;1/12/2014;30/11/2019;;Rare diseases (RD) are diseases that affect not more than 5 per 10 000 persons (according to the EU definition). 7000 distinct rare diseases exist, affecting between 6% and 8% of the population (about 30 million EU citizens). The lack of specific health policies for rare diseases and the scarcity of the expertise, translate into delayed diagnosis, few medicinal products and difficult access to care. That is why rare diseases are a prime example of a research area that strongly profits from coordination on a European scale. At present only few European countries fund research on rare diseases through specific dedicated programmes. Therefore, the funding of transnational collaborative research is the most effective joint activity to enhance the cooperation between scientists working on rare diseases in Europe and beyond. The E-Rare consortium was built to link responsible funding bodies that combine the scarce resources and fund rare disease research via Joint Transnational Calls (JTCs). The current E-Rare-3 project proposal will extend and strengthen the transnational cooperation by building on the experience and results of the previous E-Rare-1&2 programmes. The consortium comprises 26 institutions from 17 European, Associated and non-European countries. Its international dimension will be directly translated into close collaboration with IRDiRC and other relevant European and international initiatives. IRDiRC guidelines and policies will be implemented in the four JTCs and representatives of the IRDiRC Scientific Committees will be invited to join the Advisory Board of E-Rare-3. Members of the EUCERD group will be involved in identifying rare disease research needs. Patients organizations from Europe (represented by EURORDIS) and beyond will be invited as a key partner towards collaborative efforts for research promotion and funding. The collaboration with European Research Infrastructures will be consolidated to enhance efficient and participative research.;23290000;5884310;H2020-HCO-2014;ERA-NET-Cofund;AGENCE NATIONALE DE LA RECHERCHE;FR;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;FONDS DE RECHERCHE DU QUEBEC - SANTE;DEUTSCHE FORSCHUNGSGEMEINSCHAFT;MINISTERO DELLA SALUTE;FONDS ZUR FRDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG;SCHWEIZERISCHER NATIONALFONDS ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG;BUNDESMINISTERIUM FUER BILDUNG UND FORSCHUNG;FONDS VOOR WETENSCHAPPELIJK ONDERZOEK-VLAANDEREN;INSTITUTO DE SALUD CARLOS III;GENOME CANADA;ZORGONDERZOEK NEDERLAND ZON;NEMZETI KUTATASI FEJLESZTESI ES INNOVACIOS HIVATAL;REGIONE EMILIA ROMAGNA;MINISTRY OF HEALTH;CANADIAN INSTITUTES OF HEALTH RESEARCH;NARODOWE CENTRUM BADAN I ROZWOJU;ORSZAGOS TUDOMANYOS KUTATASI ALAPPROGRAMOK IRODA;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii;VALSTS IZGLITIBAS ATTISTIBAS AGENTURA;ISTITUTO SUPERIORE DI SANITA;GENIKI GRAMMATIA EREVNAS KAI TECHNOLOGIAS;LATVIJAS ZINATNU AKADEMIJA;FONDS NATIONAL DE LA RECHERCHE SCIENTIFIQUE;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"DE;AT;CA;IT;CH;BE;ES;NL;HU;IL;PL;TR;RO;LV;EL;PT"; 194265;644960;ENDEAVOUR;SIGNED;H2020-EU.2.1.1.3.;ICT-05-2014;H2020;Towards a flexible software-defined network ecosystem;1/01/2015;31/12/2017;;The focus of the project is to enable added-value services to be provided thanks to SDN, on top of Internet Exchange Points and other network interconnnection fabrics. The services would relate not only to the flexibility of the interconnection fabric, but most importantly to enable the content and data centre ecosystem that is present at the interconnection fabric to collaborate. The ultimate goal is to create a service marketplace on top of the ecosystem composed of Cloud/data centers, networked applications, and the interconnection fabric.;4294265,5;3342265,5;H2020-ICT-2014-1;RIA;QUEEN MARY UNIVERSITY OF LONDON;UK;"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE;IBM RESEARCH GMBH;UNIVERSITE CATHOLIQUE DE LOUVAIN;DE-CIX Management GmbH;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS";"UK;CH;BE;DE;FR"; 194061;643399;SMART4MD;SIGNED;H2020-EU.3.1.;PHC-20-2014;H2020;Support, Monitoring and Reminder Technology for Mild Dementia;1/04/2015;31/03/2019;;"As Europes population is ageing, long-term care for elderly citizens will become an increasing cost for society. To manage this transition healthcare policies in the EU and individual Member States are heavily focussed on extending the independent life of the elderly, with the dual aim of increasing their quality of life and reducing the costs of care. Dementia affects more than 6% of people aged 60\ and has a devastating effect on their independence to date, there is no proven intervention to help dementia patients live a fulfilling life for longer.

In this project we will build on an innovative patient support tool to develop a mHealth application that is specifically targeted to patients with mild dementia. The tool will help patients to adhere to their treatment and share data with their carers and doctors; carers will use the same application to monitor patients more easily and share their own well-being with doctors. This will slow the patients cognitive and functional decline, avoid carers getting exhausted and reduce costs of emergency care.

Our project will comprise two phases: first we will use digital accessibility tools to re-design the existing application for dementia patients. The development will be steered by patients, carers and doctors, through user-centric design: we will collect feedback on each new version of the application until the design is perfectly adapted to the users needs. In the second phase we will pilot the optimised application with 1,100 users (patients \ carers) and 1,100 controls. This will show the clinical and social benefits for patients and carers, as well as financial benefits for the healthcare system.

Successful delivery of the pilot will increase patients adherence to treatment (10 %-points), while improving the quality of life of carers and patients. It will save healthcare providers 1,818 / patient / year in care costs and will generate revenue of over 18 million / year for the consortium (Year 5).";4363280;4194417,5;H2020-PHC-2014-single-stage;IA;ANGLIA RUSKIN UNIVERSITY HIGHER EDUCATION CORPORATION;UK;"CONSORCI SANITARI DE TERRASSA;BLEKINGE TEKNISKA HGSKOLA;POW HEALTH LIMITED;ATHENA I.C.T. LTD;HANDLE MY HEALTH LIMITED;SOUTH ESSEX PARTNERSHIP UNIVERSITYNHS FOUNDATION TRUST;UC LIMBURG;ALZHEIMER EUROPE;DEX INNOVATION CENTRE;UNIVERSIDAD POLITECNICA DE MADRID;SERVICIO ANDALUZ DE SALUD";"ES;SE;UK;IL;BE;LU;CZ"; 194343;645636;FlyHigh;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Insect-plant relationships: insights into biodiversity and new applications;1/07/2015;30/06/2018;;"FlyHigh studies underexplored phytophagous and saprophagous flies and geophyte plants aiming to obtaining ecological and evolutionary data that will be used to elucidate ecological features of fly species that could be exploited for artificial mass production of flies. Artificial mass rearing of flies produces beneficial end products, the flies themselves or their larval stages, that could be applied for different services in agriculture, ecological farming or as bio-agents for e.g. complementary pollination services in natural or greenhouse environments. The main aim is to facilitate cross-sectorial transfer of knowledge and training of researchers as well as technical staff in bridging the gap between scientific results and their application into novel business ideas.
The excellence of the project lies in the synergy of basic and applied ecology for exploring and developing new protocols and end products. FlyHigh brings together experts with well documented scientific achievements of the focal organismal groups and on evolutionary analyses with early stage researchers with the same research focus, with experts on insect mass rearing techniques. The relevance of FlyHigh results from integration of project aims that may result in innovative results of broader impact that will benefit the ERA institutions as well as the TC partner. The results could be advantageous in developing new ideas for future use e.g. flies could complement or even replace the presently used managed pollinators in greenhouse productions of many greenhouse products. The obtained data will also allow us to estimate the possible biogeographic events that can help explain the evolutionary history, current distributions and future biogeographic patterns of some bulb plant and fly groups in South Africa and in Euro-Mediterranean region. The outlined training course, workshops and secondments ensure transfer of knowledge between participant academic and non-academic partners, in both directions.";450000;450000;H2020-MSCA-RISE-2014;MSCA-RISE;HELSINGIN YLIOPISTO;FI;"UNIVERSIDAD DE ALICANTE;University of Novi Sad Faculty of Sciences;BIOFLYTECH, SL";"ES;RS"; 194199;644378;smart-MEMPHIS;SIGNED;H2020-EU.2.1.1.1.;ICT-02-2014;H2020;Smart MEMs Piezo based energy Harvesting with Integrated Supercapacitor and packaging;15/12/2014;14/12/2018;;"Smart-MEMPHIS project addresses the increasing demand for low-cost, energy-efficient autonomous systems by focusing on the main challenge for all smart devices - self-powering. The project aims to design, manufacture and test a miniaturized autonomous energy supply based on harvesting vibrational energy with piezo-MEMS energy harvesters. The project will integrate several multi-functional technologies and nanomaterials; lead-zirconate-titanate materials in MEMS-based multi-axis energy harvester, an ultra-low-power ASIC to manage the variations of the frequency and harvested power, a miniaturized carbon-nano material based energy storing supercapacitor, all heterogeneously integrated with new innovative flat panel packaging technologies for cost effective 3D integration verified through manufacturability reviews.

The performance of the system will be demonstrated in two demanding applications: leadless bio-compatible cardiac pacemaker and wireless sensor networks (WSN) for structure health monitoring (SHM). For the pacemaker, a smart energy autonomous system will accelerate the paradigm shift from costly, burdensome surgical treatments to cost-effective and patient-friendly minimally invasive operations enabled by leadless pacemakers capable of harvesting energy from the heart beats. The key challenges for the energy harvesting arise from the extremely stringent reliability requirements, the low vibrational energies and frequencies and the small size required for a device implanted inside a heart.

With the 2nd demonstrator the consortium consisting of multi-functional value chain will show a wider applicability for the technologies complementing the medical application. A WSN with acoustic sensor nodes will be demonstrated in SHM applications. SHM enables real-time monitoring of complex structures e.g. survey and detection of micro-cracks for example in composite aircraft wings, bridges or rails, or detection of corrosion or leakage in pipes solving.";8222065,75;8222065,75;H2020-ICT-2014-1;RIA;SILEX MICROSYSTEMS AB;SE;"VERMON SA;LINKOPINGS UNIVERSITET;SPINVERSE INNOVATION MANAGEMENT OY;CHALMERS TEKNISKA HOEGSKOLA AB;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;SPINVERSE AB;aixACCT Systems GmbH;SORIN CRM SAS;CAIRDAC;RISE ACREO AB";"FR;SE;FI;DE"; 194059;643390;HNN 2.0;SIGNED;H2020-EU.3.1.;HCO-16-2014;H2020;Improving and professionalizing the Health NCP service across Europe.;1/12/2014;30/11/2018;;"Health NCP Net 2.0 aims at improving and professionalizing the NCP service, thus achieving a more consistent level of NCP support services across Europe with the final goal to better support applicants and raise the average quality of proposals submitted.
HNN 2.0 builds upon the experience and results of the previous Health NCP Net project with the objective of responding to the new challenges that the Health, Demographic Change and Wellbeing NCPs face in the new programme Horizon 2020, such as the broadened thematic scope of the Societal Challenge 1, and the enlarged mandate of the Health NCPs. An objective of the HNN 2.0 project is to satisfy the needs and priorities of all different types of NCPs, notably newcomers, NCPs with fewer resources, NCPs from EU-13 and NCPs in Third Countries so as to face the challenge of the current heterogeneity of the network
The enlarged mandate of Health NCPs and the holistic focus of H2020 imply that NCPs need to create expert knowledge and look for it outside the SC1 Network by having a holistic approach and liaising and collaborating with other support structures, projects and programmes. HNN 2.0 will therefore have a real structured coordination with the other NCP and support networks such as Ideal-IST, EEN and Fit for Health 2.0, where collaboration for joint activities like training courses, meet and exchange workshops and brokerage events is established. Main tools towards the objectives:
- support and information materials
- comprehensive training programme
- mentoring programme (staff exchanges, mentoring programme for EU-13, twinning with the European Commission)
- Meet and Exchange workshops with NCPs from other disciplines
- system of email alert for NCPs about research funding and related policies
- information and communication hub for SC1-NCPs (easy access to information and services , exchange of information and opinions between SC1-NCPs)
- International brokerage events";2082673,75;1999548,75;H2020-HCO-2014;CSA;INSTITUTO DE SALUD CARLOS III;ES;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;OESTERREICHISCHE FORSCHUNGSFOERDERUNGSGESELLSCHAFT MBH;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;AGENCE BRUXELLOISE POUR L'ENTREPRISE;INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK;The Technology Strategy Board;AGENCIJA ZA MOBILNOST I PROGRAME EUROPSKE UNIJE;VEREIN EURESEARCH;ETHNIKO IDRYMA EREVNON;MATIMOP - THE ISRAELI CENTER FOR R&D;AGENZIA PER LA PROMOZIONE DELLA RICERCA EUROPEA;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"DE;AT;FR;BE;PL;UK;HR;CH;EL;IL;IT;PT"; 194097;643736;EmERGE;SIGNED;H2020-EU.3.1.;PHC-26-2014;H2020;Evaluating mHealth technology in HIV to improve Empowerment and healthcare utilisation: Research and innovation to Generate Evidence for personalised care;1/05/2015;30/04/2020;;EmERGE will develop a mHealth platform to enable self-management of HIV in patients with stable disease. The platform will build upon and integrate the existing mHealth solutions operated by pioneering healthcare providers in the UK and Spain and apply a rigorous co-design approach to ensure patient and clinician input to the solution. The platform will provide users with web based and mobile device applications which interface securely with relevant medical data and facilitate remote access to key healthcare providers EATG, the European HIV patient organisation, will provide a direct and deep interaction with representative patients and clinicians from 5 EU countries. The platform and interfaces will be validated in a large study of 3900 patients using a tailored HTA process, MAST, specifically developed for the assessment of mHealth solutions including translatability as a key factor. Based on prior work showing a high uptake rate and use of mHealth in HIV patient populations, EmERGE aims to demonstrate the benefits to patients and simultaneous increases in cost-effectiveness for healthcare providers by reducing face-to-face consultations, estimated at 6000 saved per year within this study alone. Patient reported outcomes will be agreed and used in the assessment and development of the system which also aims to increase adherence and enable frailty to be reported using mHealth technology. Innovation will be given priority from the beginning by developing new business models of care provision, targeting key stakeholders in the EU health provider sector, including policymakers and clinicians, while eliciting demand from patients to highlight and initiate the widespread implementation and compensation of mHealth solutions within the timeframe of the project. Guidelines and policy briefs will be produced to evidence the benefits and disseminate the lessons learned to support the uptake of mHealth for self-management of other chronic diseases.;5457480,14;5457480,14;H2020-PHC-2014-single-stage;RIA;BRIGHTON AND SUSSEX UNIVERSITY HOSPITALS NHS TRUST;UK;"PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE;FUNDACIO PRIVADA CLINIC PER A LA RECERCA BIOMEDICA;UNIVERSITY OF BRIGHTON;Kite Innovation (Europe) Limited;CENTRO HOSPITALAR DE LISBOA CENTRAL, EPE;KLINIKA ZA INFEKTIVNE BOLESTI DR. FRAN MIHALJEVIC;UNIVERSITY OF SUSSEX;PODMEDICS LIMITED;NPMS-HHC CIC;European AIDS Treatment Group;UNIVERSIDAD POLITECNICA DE MADRID;MHEALTH FUTURES LTD";"BE;ES;UK;PT;HR;DE"; 194156;644121;MIXMAX;SIGNED;H2020-EU.1.3.3.;MSCA-RISE-2014;H2020;Development and Implementation of new generation of Pseudo Random Number Generators based on Kolmogorov-Anosov K-systems;1/01/2015;31/12/2018;;"Modern powerful computers open a new era for the application of the Monte Carlo method for the simulation of physical systems of higher complexity. The Monte Carlo simulations are important computational techniques in many areas of natural sciences and have significant application in particle and nuclear physics, quantum physics, statistical physics, quantum chemistry, material science, among many other multidisciplinary applications. In the heart of the Monte Carlo simulations are Pseudo Random Number Generators (RNG). The primary objective of the proposed network is a systematic development and implementation of the state of the art new generation of Pseudo Random Number Generators based on Kolmogorov-Anosov K-systems, which demonstrates excellent statistical properties, into a multidisciplinary usable product. This innovative class of RNG was proposed earlier by the members of the network and relies on the fundamental discoveries and results of Ergodic theory. In order to turn these ideas and earlier research on K-systems generators into a usable product the network undertakes the following actions: To develop an efficient program of the K-system generator with tunable internal parameters of maximal dimensionality and of the order of the Galois field, embedded into a user friendly environment and with an on-line manual; To provide statistical data representing internal characteristics of the K-system generator as a function of the dimensionality of the generator and of the order of the Galois field; To implement the K-system generator into the concurrent and distributed software at CERN for applications in LHC and other HEP experiments; To perform large scale simulations in Quantum Gravity and Quantum Field Theory based on K-system generator. To disseminate the product at CERN and other research centers.These objectives will be achieved by secondments,exchange of knowledge, collective research and training between staff members of the five partners.";360000;252000;H2020-MSCA-RISE-2014;MSCA-RISE;"""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS""""""";EL;"KOBENHAVNS UNIVERSITET;EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH";"DK;CH"; 194180;644270;SLALOM;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Service Level Agreement - Legal and Open Model;1/01/2015;30/06/2016;;"SLALOM is a support action tackling the complexity of cloud computing SLAs and contracts through standardisation of the SLA and contract terms and a reference model for SLA management. In doing so it will support the adoption of cloud (SLA complexity is an identified barrier to adoption) and support the exploitation of results from the cloud and SLA research communities, effectively by factoring in advances from the research sector into the SLALOM legal and technical models which will be promoted as industry standards.

The project will involve interaction with policy makers, cloud providers, research projects and cloud adopters from various areas. There will be significant interaction with the policy groups set up under the European Cloud Partnership and the working groups of the research community. The project will run for 18 months, focusing on three phases definition of the models; consensus building; and adoption.";702813;702813;H2020-ICT-2014-1;CSA;ATOS SPAIN SA;ES;"CLOUD INDUSTRY FORUM LIMITED;STUDIO LEGALE BIRD & BIRD;UNIVERSITY OF PIRAEUS RESEARCH CENTER;INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS";"UK;IT;EL"; 194159;644164;Road2CPS;SIGNED;H2020-EU.2.1.1.1.;ICT-01-2014;H2020;Strategic action for future CPS through roadmaps, impact multiplication and constituency building;1/02/2015;31/01/2017;;"The miniaturisation of sensing, actuating, and computing components together with the increasing number of interacting systems in strongly connected environments, and the growing complexity of such systems have triggered a paradigm shift. CPS concepts address challenges for system implementation such as increasing complexity and flexibility. These challenges and the need to optimise performance and comply with essential requirements like safety and security raise many questions that are partially addressed by current research in areas such as transport, health, production, smart grids and smart cities already. Nevertheless, there is still a huge gap between theoretical concepts, technical developments, and successful application, as well as considerable differences with regard to propagation and maturity of CPS between application domains and along the value chain. Strategic action is needed to bring the relevant stakeholders together and to facilitate mutually beneficial collaborations between them.
Road2CPS has been conceived to respond to this situation by
Analysing impact from past and ongoing projects, identifying gaps and bridging efforts towards impact multiplication
Developing technology, application and innovation strategy roadmaps for CPS to serve as a catalyst for early adoption of CPS technologies
Enhancing CPS implementation and exposing exploitation opportunities via case studies
Developing recommendations for future research priorities and implementation strategies
Building a CPS constituency bringing together key players into targeted task forces to contribute to the Road2CPS action plan
This will provide European organisations with the direction required to establish their future visions of CPS environments, supporting their efforts to stay at the forefront of new developments and preparing them for future challenges in the industrial application of CPSs; thus reinforcing the leading position of the European industry in CPS.";832893,5;832893,5;H2020-ICT-2014-1;CSA;STEINBEIS 2I GMBH;DE;"ANYSOLUTION SL;COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES;UNIVERSITY OF NEWCASTLE UPON TYNE;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;STEINBEIS INNOVATION GGMBH;LOUGHBOROUGH UNIVERSITY;ATOS SPAIN SA";"ES;FR;UK;DE"; 194423;646296;Hi-Response;SIGNED;H2020-EU.2.1.2.1.;NMP-04-2014;H2020;Innovative High Resolution Electro-Static printing of Multifunctional Materials.;1/03/2015;31/08/2018;;"The EU is well placed to exploit printed electronic technologies to create greater economic and social benefits for the EU, but only if we are able to commercialise innovative technologies created within the EU.

Ink jet printing technologies are at the forefront of printed electronic developments. However, Ink jet printing has only been able to achieve a resolution of >=10um and the viscosity of printable inks is limited to <40 centipoise, this further limits the solids content of inks to <30-Vol% and the size of the nano-fillers to <50nm typically. These factors limit the range of functional inks that can be printed as well as the resolution and final properties of the resultant printed/sintered structures and components.

The HI-RESPONSE project is based on highly innovative, patented Electro-static printing technology (ESJET) that has already been proven on TRL 4 to print to a resolution of 1um and be able to print inks with a viscosity of up to 40.000 cP. The resultant printed/sintered structures will therefore be able to achieve a high resolution and increase final component properties through enabling the printing of highly filled nano-inks and functional organic materials.

This technology will be further developed to TRL 6 within the project to allow for the design and assembly of a multi-head system that can achieve resolution, speeds and cost that far surpassed that of current ink-jet systems. The resultant system will be demonstrated at TRL 6 for a wide range of materials, including: nano-Cu and nano-ceramic filled inks and organic polymers. Each of these materials will be printed to create components specifically defined and specified by the industrial organisations within the consortium: Infineon, Ficosa, Piher (Meggitt) and Zytronic. The specific end-user defined applications are: Automotive aerials and sensors, metal meshed for OLED and touch screens, conductive through silicon vias and mechanical strengthening ribs for thin Si-wafers.";7887826,25;6444022,63;H2020-NMP-PILOTS-2014;IA;PRECISION VARIONIC INTERNATIONAL LIMITED;UK;"PIHER SENSORS & CONTROLS SA;NANOTECCENTER WEIZ FORSCHUNGSGESELLSCHAFT MBH;JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH;NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO;ORBOTECH LTD;ZYTRONIC PLC;INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;INFINEON TECHNOLOGIES AUSTRIA AG;INTRINSIQ MATERIALS LIMITED;BIONANONET FORSCHUNGSGESELLSCHAFT MBH;QUEEN MARY UNIVERSITY OF LONDON;ADVANCED AUTOMOTIVE ANTENNAS S.L";"ES;AT;NL;IL;UK;BE;DE"; 194218;644579;ESCUDO-CLOUD;SIGNED;H2020-EU.2.1.1.3.;ICT-07-2014;H2020;Enforceable Security in the Cloud to Uphold Data Ownership;1/01/2015;31/12/2017;;Cloud computing is increasingly a necessary strategical ICT infrastructure component for European companies to successfully compete in the world-wide economy. The advantages of renting ICT infrastructures, platforms, and services, with easy access to scalability and elasticity, are driving an ever accelerating transfer toward the cloud of data and applications. Unfortunately, such a convenience comes at the price of the data owners losing control over their own data and any consequent misuse or security threats on them, which often limit the owner's adoption of the cloud's potential capabilities. On one hand, cloud providers can be assumed to employ basic security mechanisms for protecting data in storage, processing, and communication, devoting resources to ensure security that many medium and small companies may not be able to afford. On the other hand, data owners, when relying on the cloud, lose control over data and their processing, hence leaving them potentially exposed. Today data owners have to choose between having security but limited functionality or fully enjoying functionality but compromising on security and privacy guarantees. This situation has a strong detrimental impact on the adoption and acceptability of cloud services. Data owners may refrain from relying on the cloud for certain data, which they consider more sensitive or critical, or they use the cloud but remain exposed to the consequences of improper protection and control. The goal of ESCUDO is to empower data owners as first class citizens of the cloud. ESCUDO provides effective and deployable solutions allowing data owners to maintain control over their data when relying on Cloud Service Providers (CSPs) for data storage, processing, and management, without sacrificing on functionality. ESCUDO consortium sees the participation of major industry players in the cloud area, and of an innovative SME, contributing real-world use cases, and providing strong exploitation and impact.;4822750;3827000;H2020-ICT-2014-1;RIA;UNIVERSITA DEGLI STUDI DI MILANO;IT;"SAP SE;IBM RESEARCH GMBH;EMC INFORMATION SYSTEMS INTERNATIONAL;WELLNESS TELECOM SL;BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY;TECHNISCHE UNIVERSITAT DARMSTADT;UNIVERSITA' DEGLI STUDI DI BERGAMO";"DE;CH;IE;ES;UK;IT"; 194297;645220;RAWFIE;SIGNED;H2020-EU.2.1.1.3.;ICT-11-2014;H2020;Road-, Air- and Water-based Future Internet Experimentation;1/01/2015;31/12/2018;;The purpose of the RAWFIE initiative is to create a federation of different network testbeds that will work together to make their resources available under a common framework. Specifically, it aims at delivering a unique, mixed experimentation environment across the space and technology dimensions. RAWFIE will integrate numerous testbeds for experimenting in vehicular (road), aerial and maritime environments. A Vehicular Testbed (VT) will deal with Unmanned Ground Vehicles (UGVs) while an Aerial Testbed (AT) and a Maritime Testbed (MT) will deal with Unmanned Aerial Vehicles (UAVs) and Unmanned Surface Vehicles (USVs) respectively. The RAWFIE consortium includes all the possible actors of this highly challenging experimentation domain, from technology creators to integrators and facility owners. The basic idea behind the RAWFIE effort is the automated, remote operation of a large number of robotic devices (UGVs, UAVs, USVs) for the purpose of assessing the performance of different technologies in the networking, sensing and mobile/autonomic application domains. RAWFIE will feature a significant number of UxV nodes for exposing to the experimenter a vast test infrastructure. All these items will be managed by a central controlling entity which will be programmed per case and fully overview/drive the operation of the respective mechanisms (e.g., auto-pilots, remote controlled ground vehicles). Internet connectivity will be extended to the mobile units to enable the remote programming (over-the-air), control and data collection. Support software for experiment management, data collection and post-analysis will be virtualized to enable experimentation from everywhere in the world. The vision of Experimentation-as-a-Service (EaaS) will be promoted through RAWFIE. The IoT paradigm will be fully adopted and further refined for support of highly dynamic node architectures.;8319384;6995729;H2020-ICT-2014-1;RIA;ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON;EL;"HELLENIC AEROSPACE INDUSTRY SA;ASSOCIATION PEGASE;INTELLIGENCE FOR ENVIRONMENT AND SECURITY SRL IES SOLUTIONS SRL;ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS;CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT;MINISTRY OF NATIONAL DEFENCE, GREECE;OCEANSCAN - MARINE SYSTEMS & TECHNOLOGY LDA;FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;AVIONTEK GMBH;ABERON OOD;HAUTE ECOLE SPECIALISEE DE SUISSE OCCIDENTALE;ROBOTNIK AUTOMATION SLL";"EL;FR;IT;CH;PT;DE;BG;ES"; 194065;643434;GlOPID-R-Sec;SIGNED;H2020-EU.3.1.;HCO-04-2014;H2020;Global Research Collaboration for Infectious Disease Preparedness (GloPID-R) Secretariat;1/01/2015;31/12/2019;;"GLOPID-R-Sec is the secretariat to the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R). The secretariat will be staffed by Fondation Mrieux and the University of Oxford, and will provide the following support activities to the GloPID-R member organisations, working groups and commitees:
- Organizational, financial-administrative and secretarial support activities to the GloPID-R governance structure ensuring efficient information exchange amongst all GloPID-R members and stakeholders;
- Connecting GloPID-R to relevant research networks, and mapping of their current scientific and operational status in terms of research preparedness in support of the development of operational readiness towards initiating a rapid coordinated international research response to emerging infectious disease outbreaks, This will include mapping of different, interrelated barriers (scientific, infrastructural, human resource capacities and skills, political, ethical, regulatory, legal, societal, ICT, financial);
- Assisting GloPID-R in the development of a strategic agenda and a readiness plan that serve as common and central guiding documents for all members and external stakeholders.
- Developing and implementing a comprehensive communication and dissemination plan for information sharing within the GloPID-R community, to ensure stakeholders are well-informed and aligned, and to raise public awareness about and engagement in the initiative.
Fondation Mrieux and the University of Oxford can build on ongoing efforts and the results thereof of high relevance to GloPID-R, in their respective lined networks such as AVIESAN and ISARIC. Fondation Mrieux will be the coordinator of GloPID-R-Sec, with its office at Lyon, France as the central point of contact of the Secretariat.";2896399,8;2896399,8;H2020-HCO-2014;CSA;FONDATION MERIEUX;FR;THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD;UK; 194086;643638;TRANSCAN-2;SIGNED;H2020-EU.3.1.;HCO-08-2014;H2020;ERA-NET: Aligning national/regional translational cancer research programmes and activities;1/01/2015;31/12/2019;;"Cancer is a worldwide health burden and represents a major public health challenge in Europe. It is responsible for 25% of all deaths, being the second most common cause of death after cardio-vascular diseases and the main cause of mortality among people aged 4564. Today, an estimated 9 million individuals in Europe live with cancer (Globocan 2008, http://globocan.iarc.fr/). Cancer became a chronic disease which contributed substantially to the growth of medical expenditures and constitutes a major socio-economic challenge for Europe as well as globally. A rapid and effective bidirectional transfer of relevant cancer research findings between bench and bedside would play a pivotal role in addressing top-priority needs at the EU level to reduce incidence and mortality of malignancies and to improve the quality of life of cancer patients.
The proposed ERA-NET Cofund TRANSCAN-2, in continuity with the preceding and ongoing TRANSCAN ERA-NET, aims at linking translational cancer research funding programmes in 15 Member States, 3 Associated Countries, and a third country. By concentrating transnational resources, TRANSCAN-2 will provide a critical financial and scientific mass for tackling large-scale problems, relevant for improving translational cancer research globally.
A co-funded joint transnational call (JTC) will be launched focusing on the topic Intratumour heterogeneity in resistance to therapy and recurrence followed by three additional JTCs that will be implemented in a frame of multinational translational cancer research programmes. In addition, strategies will be developed for the enlargement of the network, for improvement of coordination and for an efficient communication and dissemination of the results of the consortium as well as of the research projects funded through the JTCs. The monitoring of the projects funded through the JTCs and the critical assessment of the performance of TRANSCAN-2, based on key indicators, will be also realised.";22568750;6672187;H2020-HCO-2014;ERA-NET-Cofund;MINISTERO DELLA SALUTE;IT;"DEUTSCHES ZENTRUM FUER LUFT - UND RAUMFAHRT EV;FONDATION ARC POUR LA RECHERCHE SUR LE CANCER;FONDS ZUR FRDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG;Kreftforeningen;SIHTASUTUS EESTI TEADUSAGENTUUR;BUNDESMINISTERIUM FUER BILDUNG UND FORSCHUNG;FUNDACION PARA EL FOMENTO EN ASTURIAS DE LA INVESTIGACION CIENTIFICA APLICADA Y TECNOLOGIA;ALLEANZA CONTRO IL CANCRO;FONDS VOOR WETENSCHAPPELIJK ONDERZOEK-VLAANDEREN;INSTITUTO DE SALUD CARLOS III;MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITA' E DELLA RICERCA;INSTITUT NATIONAL DU CANCER;ZORGONDERZOEK NEDERLAND ZON;MINISTRY OF SCIENCE AND TECHNOLOGY;STICHTING KONINGIN WILHELMINA FONDS VOOR DE NEDERLANDSE KANKERBESTRIJDING;NORGES FORSKNINGSRAD;SLOVENSKA AKADEMIA VIED;MINISTRY OF HEALTH;NARODOWE CENTRUM BADAN I ROZWOJU;TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU;VALSTS IZGLITIBAS ATTISTIBAS AGENTURA;Orszagos Onkologiai Intezet;Ministrstvo za izobrazevanje, znanost in sport;ISTITUTO SUPERIORE DI SANITA;GENIKI GRAMMATIA EREVNAS KAI TECHNOLOGIAS;LATVIJAS ZINATNU AKADEMIJA;FONDS NATIONAL DE LA RECHERCHE SCIENTIFIQUE;FUNDACAO PARA A CIENCIA E A TECNOLOGIA";"DE;FR;AT;NO;EE;ES;IT;BE;NL;TW;SK;IL;PL;TR;LV;HU;SI;EL;PT"; 194050;643368;INNOV-ACTIS;SIGNED;H2020-EU.2.3.;INNOSUP;H2020;INNOV-ACTIS;1/05/2014;31/12/2014;;"The objective of this project is to provide innovation support services to SMEs in the regions covered by the consortium members. These innovation support services will be differentiated for two groups of SMEs:

SMEs that have been selected as beneficiaries of the SME instrument, phase 1 or phase 2. For these companies, the consortium members will offer Key Account Management (KAM) services, which are accompanying services for the SMEs to identify weaknesses in their innovation capacities and suitable external coaches throughout their participation in the SME instrument.

SMEs that have high potential for growth and internationalisation but that need to improve their innovation management capacities. These companies will receive direct assessment services from the consortium members in order to detect barriers and develop and implement an action plan in order to enhance such capacities and overcome the detected barriers.";56000;44800;H2020-Adhoc-2014-20;CSA;INSTITUTO TECNOLOGICO DE ARAGON;ES;"FUNDACION FUNDECYT - PARQUE CIENTIFICO Y TECNOLOGICO DE EXTREMADURA;CONFEDERACION DE EMPRESARIOS DE ARAGON;UNIVERSIDAD DE NAVARRA;AGENCIA DE DESARROLLO ECONOMICO DE LA RIOJA;UNIVERSIDAD DE CASTILLA - LA MANCHA;ASOCIACION DE LA INDUSTRIA NAVARRA;FEDERACION DE EMPRESARIOS DE LA RIOJA";ES; 194250;644843;VITAL;SIGNED;H2020-EU.2.1.1.3.;ICT-06-2014;H2020;VIrtualized hybrid satellite-TerrestriAl systems for resilient and fLexible future networks;1/02/2015;31/07/2017;;"VITAL is an ambitious proposal addressing the combination of Terrestrial and Satellite networks by pursuing two key innovation areas, by bringing Network Functions Virtualization (NFV) into the satellite domain and by enabling Software-Defined-Networking (SDN)-based, federated resources management in hybrid SatCom-terrestrial networks. Enabling NFV into SatCom domain will provide operators with appropriate tools and interfaces in order to establish end-to-end fully operable virtualised satellite networks to be offered to third-party operators/service providers. Enabling SDN-based, federated resource management paves way for a unified control plane that would allow operators to efficiently manage and optimise the operation of the hybrid network. While innovations pursued by VITAL are transversal, the project will primarily focus on three key application scenarios: Satellite Virtual Network Operator (SVNO) services, Satellite backhauling and hybrid telecom service delivery.
The solutions developed in VITAL will bring, through flexible integration of satellite and terrestrial segments, improved coverage, optimised communication resources use and better network resilience, along with improved innovation capacity and business agility for deploying communications services over combined networks. VITAL will address the development of a hybrid architectural framework, the required mechanisms to enable virtualization of SatCom network components, including performance optimisation and implementation of a number of virtualised functions, and the design of an SDN-enabled, federated resources management framework, embedding strategies and algorithmic solutions to provide end-to-end communication services.
Proof of Concept validation of VITAL solutions and enabling technologies through a combination of real prototypes and emulators are also envisaged. The project aims to impact standardization initiatives and will contribute to open platform initiatives for SDN/NFV deployments.";2896855;2896855;H2020-ICT-2014-1;RIA;CREATE-NET (CENTER FOR RESEARCH AND TELECOMMUNICATION EXPERIMENTATION FOR NETWORKED COMMUNITIES);IT;"SYNAPTEC;INTECS SPA;CENTRE NATIONAL D'ETUDES SPATIALES - CNES;HELLENIC TELECOMMUNICATIONS ORGANIZATION S.A. - OTE AE (ORGANISMOS TILEPIKOINONION TIS ELLADOS OTE AE);UNIVERSITAT POLITECNICA DE CATALUNYA;ELLAS SAT ANONYMH ETAIREIA YPIRESIES DORYFORIKON SYSTIMATON KAI EPIKOINONION;""NATIONAL CENTER FOR SCIENTIFIC RESEARCH """"DEMOKRITOS"""""";ONEACCESS SA";"FR;IT;EL;ES"; 194282;645101;SmokeBot;SIGNED;H2020-EU.2.1.1.5.;ICT-23-2014;H2020;Mobile Robots with Novel Environmental Sensors for Inspection of Disaster Sites with Low Visibility;1/01/2015;30/06/2018;;SmokeBot is driven by the application needs for robots that operate in domains with restricted visibility. The focus is on civil robots supporting fire brigades in search and rescue missions, e.g. in post-disaster management operations in response to tunnel fires. Existing sensor technology and the related cognitive approaches cannot cope with such demanding conditions. SmokeBot addresses this shortcoming and can thus bring about a step change for robotics. It will deliver software and hardware components which facilitate robot systems to perform under harsh conditions of smoke, dust or fog. This will be demonstrated through integration of the project results in an industrial prototype of a Low Visibility Explorer Robot for providing situational awareness based on a commercial platform from partner TAUR. In close collaboration with TAUR (robotics industry) and end users (FDDO, end users in the advisory group), SmokeBot will crucially improve the abilities of the selected platform, thus increasing safety of rescue staff and European citizens as well as improving the product of a European robotics company in an important market. An even wider impact is expected through the development of a novel sensor unit and the corresponding cognitive approaches. In addition to traditional sensors such as LIDAR and cameras, which are affected by smoke or dust, this sensing unit includes also a novel 3D radar camera, a thermal camera, and high-bandwidth gas sensors. Fusion of sensor modalities will allow the inclusion of measurements from LIDAR and camera into the world model when they occasionally penetrate through e.g. smoke. In addition, we will develop the means to integrate prior knowledge in the form of crude human sketch maps to allow for robust mapping and navigation even under low visibility in a harsh environment. Sensor technology from SmokeBot will result in new products to be brought to market after the project. Software developed will be made available as open source.;3817417,7;3817417,5;H2020-ICT-2014-1;RIA;OREBRO UNIVERSITY;SE;"FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;THE UNIVERSITY OF WARWICK;STADT DORTMUND;TAUROB GMBH;GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER";"DE;UK;AT"; 194035;643343;MED4INNO;SIGNED;H2020-EU.2.3.;INNOSUP;H2020;French MEDiterranean Support for INNOvative SMEs;1/06/2014;31/12/2014;;"MED4INNO Project proposal is an extension of the running MED2EUROPE Project financed under Competitiveness Innovation Program for Enterprise Europe Network activity. The project covers the whole of the French Mediterranean area with 3 regions: Provence Alpes Cte dAzur, Languedoc-Roussillon and Corsica (NUTS-1 FR7). The project will be carried out by 3 partners in the 2 major regions (PACA and LR) as Corsica cannot implement this Specific Action for 2014:
- Agence Rgionale de lInnovation et de lInternationalisation des entreprises de la rgion PACA (ARII PACA) for Provence Alpes Cte dAzur Region
- Chambre de Commerce et dIndustrie de Rgion PACA (CCIR PACA) for Provence Alpes Cte dAzur Region
- Transferts LR for Languedoc-Roussillon Region
The project aims at to put in place a reinforced SME Service Support, named Service Package, dedicating to support the growth of promising companies involved in innovative projects or benefiting SME Instrument grants. 33 Service Packages will be available during the project.
MED4INNO Project matches perfectly the work program defined by the European Commission concerning its support to SMEs. European SMEs have demonstrated for several years that they pull European growth and that they are the backbone in Europe for innovation, investment and job creation. Unfortunately innovative SMEs are often too small or too young or less capitalized than any other companies to grow. The final impact of support service provided is similar to the objective of SME Instrument: to turn our SMEs with significant innovation activities into investors ready SMEs.";105000;84000;H2020-Adhoc-2014-20;CSA;AGENCE REGIONALE POUR L'INNOVATION ET L'INTERNATIONALISATION DES ENTREPRISES DE PROVENCE ALPES COTE D'AZUR;FR;"CHAMBRE DE COMMERCE ET D'INDUSTRIE DE REGION PROVENCE ALPES COTE D'AZUR;TRANSFERTS LANGUEDOC-ROUSSILLON";FR; 194082;643597;ARISE;SIGNED;H2020-EU.3.1.;PHC-15-2014;H2020;Aortic Valve Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap;1/01/2015;31/03/2019;;"65,000 aortic valve replacements (AVR) are performed in Europe each